CN111265441A - Composition capable of enhancing skin night repair and regeneration capacity and application thereof - Google Patents
Composition capable of enhancing skin night repair and regeneration capacity and application thereof Download PDFInfo
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- CN111265441A CN111265441A CN202010179309.7A CN202010179309A CN111265441A CN 111265441 A CN111265441 A CN 111265441A CN 202010179309 A CN202010179309 A CN 202010179309A CN 111265441 A CN111265441 A CN 111265441A
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract
The invention relates to the technical field of skin care, and provides a composition capable of enhancing night repair and regeneration capacity of skin and application thereof.
Description
Technical Field
The invention relates to the technical field of skin care, in particular to a composition capable of enhancing night repair and regeneration capacity of skin and application thereof.
Background
With the development of modern society, the pace of work and life of people is faster and faster, the mental stress is larger and larger, and in addition, a plurality of external factors such as bad living habits, bad environment, ultraviolet rays and the like cause bad influence on the skin of people, more and more people face the problems of dry, rough, inelastic, dark skin color, large pores and the like. With the improvement of the quality of life, people pay more and more attention to the scientificity of skin care. Nighttime is an important time for skin repair and is a skin care consciousness of many people. At night, the skin's regenerative capacity and the cell's trophic mechanisms are activated, repairing the day-time damage to the skin. Under the skin surface, cells are undergoing activities such as recovery, regeneration and remodeling, at which time the rate of cell renewal is about 8 times faster than during the day. Therefore, during the night (when skin cell growth and repair is most vigorous), proper care and care should be given. However, with the increase of age and insufficient sleep, the skin metabolism is slowed down, and the common skin care products cannot provide efficient and high-quality care for the skin, so that the products with pertinence need to be used for corresponding maintenance and care at night.
Disclosure of Invention
The invention aims to provide a composition capable of enhancing night repair and regeneration capacity of skin, aiming at the prior technical situation.
Another object of the present invention is to provide the use of the above composition for enhancing the nighttime skin repair and regeneration ability in the preparation of drugs and/or cosmetics.
The above object of the present invention is achieved by the following technical solutions:
a composition capable of enhancing night repair and regeneration capacity of skin comprises the following components in percentage by mass:
the balance of a cosmetic or dermatologically common external preparation matrix and/or water;
the active ingredients of the compound composition A are Mirabilis jalapa extract and caffeine;
the active components of the composite composition B are complex enzyme and lecithin, and the complex enzyme comprises endonuclease, guanine glycosylase and thioredoxin.
As used herein, "active ingredient" refers to an ingredient having biological activity, including but not limited to, active ingredients.
Mirabilis jalapa is native to tropical America, Mirabilis. The seeds are oval, black and have surface stripes and folds, are perennial herbaceous flowers, have light white and fine endosperm in the jasmine seeds, and are natural ideal cosmetics. The root and leaf can be used for medicine, and has effects of clearing away heat and toxic materials, promoting blood circulation, regulating menstruation, and nourishing. The Mirabilis jalapa flower seed powder has effects of removing toxic substances, removing acne, tranquilizing mind, and caring skin.
The mirabilis jalapa extract can be derived from any part of a mirabilis jalapa plant, functional fragment cells are extracted from the mirabilis jalapa extract, dedifferentiation is carried out, then cell culture is carried out, callus is obtained after the mass propagation of mother cells in a culture solution, corresponding active substances are obtained by extracting and filtering the callus, and the active substances comprise plant polypeptides, proteins, plant polysaccharides, vitamins, amino acids and other substances. In addition, the double phospholipid structure of the cell membrane of the cell active matter in the mirabilis jalapa extract forms a natural protective film, and the cell membrane plays a role of a lipid inclusion body on active ingredients of saccharides, peptides and polyphenols, protects the activity and is beneficial to permeating into the stratum corneum of the skin.
The caffeine of the present invention is extracted from tea leaves or coffee cherries, for example, by heating with an organic solvent, or is a commercially available product, and is an alkaloid effective against free radicals that threaten our health; contains high-content polyphenol compounds, and is a powerful antioxidant; caffeine can also enhance vasoconstriction and promote blood circulation.
Through screening tests of various components, the mirabilis jalapa extract and the caffeine have a synergistic effect, and the two are matched with each other, so that the bioavailability of all active ingredients provided for skin can be increased, and specifically, the two achieve the synergistic effect of the active ingredients through the following mechanism:
(1) it can improve the activity of mitochondria, promote them to better utilize enzymes, convert glucose into ATP, and enhance the metabolism ability of cells;
(2) can reduce the formation of certain oxygen-containing free radicals (such as hydrogen peroxide H) from mitochondrial respiratory chain at night2O2Etc. free radicals causing cell damage);
(3) can prevent the skin from being obstructed in blood circulation due to endogenous oxidation, and prevent the blood microcirculation from being obstructed by free radicals formed by cell respiration. The epidermis of the skin has no blood vessels, and the blood microcirculation functions to transport nutrients to keratinocytes and promote their metabolic communication, which are also essential for the functioning of cellular functions.
Preferably, the compound composition A further comprises glycerin, and the compound composition A is prepared by compounding 79 parts by weight of glycerin, 20 parts by weight of mirabilis jalapa extract and 1 part by weight of caffeine.
Preferably, the composite composition B comprises the following components in percentage by mass: 2-4% of complex enzyme, 0.2-5.5% of lecithin and the balance of water; the compound enzyme is derived from extracts of chlorella and haematococcus pluvialis.
Haematococcus pluvialis (Haematococcus pluvialis), also known as Haematococcus pluvialis, is a unicellular green alga, which is taxonomically belonging to the phylum Chlorophyta, class Chlorophyceae, order Volvocales, family Haematococcus, genus Haematococcus.
Chlorella is a kind of spherical unicellular freshwater algae, and contains Chlorella polysaccharide, protein, vitamins, Chlorella growth factor, polyunsaturated fatty acid, etc. as active components.
The extract of chlorella and haematococcus pluvialis is extracted from an algae sample in an arctic water area and then cultivated under the same conditions, and the extraction process is not simple mixture extraction and is different from the extraction process of astaxanthin and other raw materials on the market. The component is extracted and then separated into active components which are effectively related to DNA repair in a mixture, wherein the active components comprise endonuclease, guanine glycosylase and thioredoxin, and the three enzymes account for 2% -4% of the total content of the composite composition B.
At night, there are three enzymes in the body that can repair DNA without the need for light and cellular energy, namely ultraviolet-damaged endonuclease (UVDE), guanine glycosylase (OGG1), and Thioredoxin (TRX). Chlorella vulgaris extract is rich in UVDE enzyme, and can accelerate DNA repair, and repair damaged DNA in 4 hr without light. Can reduce the production of key proinflammatory factors IL-8 and CXCL 1 to prevent the aging cascade caused by DNA damage; and can prevent aging by inhibiting the activity of angiogenin. The haematococcus pluvialis extract can strengthen a DNA repair system and an anti-oxidation system, a CPD specific antibody immunocytochemistry method and an OXO detection technology are used for carrying out detection tests (detecting damage and oxidative damage caused by ultraviolet rays), the detection result shows that the haematococcus pluvialis extract can accelerate the repair speed of DNA, and the haematococcus pluvialis extract can strengthen the anti-oxidation system of skin by means of thioredoxin.
The active ingredients of the complex enzyme extracted from chlorella and haematococcus pluvialis can effectively accelerate the night repair of DNA, enhance the night repair and regeneration capability of skin cells, strengthen the oxidation resistance of skin and delay senility.
The carnosine is a natural endogenous dipeptide, consists of β -alanine and L-histidine, has strong effects of scavenging free radicals, resisting oxidation and aging, has excellent anti-glycosylation effect, and can protect skin collagen.
(1) The anti-glycosylation of carnosine has two aspects, namely, the inhibition of glycosylation is used as a substitute to prevent the protein from the harmful effect of cross-linking carbohydrate; and secondly, the glycosylated protein is processed, so that the protein is subjected to 'carnosination', then is discharged by cells, is combined with a receptor and is degraded in lysosomes.
(2) Carnosine is a free radical scavenger and directly plays a role in quenching oxygen radicals, and histidine residues on a carnosine side chain can be used as a hydrogen acceptor, have the functions of capturing hydroxyl free radicals, simple substance oxygen and hydrogen peroxide free radicals and can always include the fat oxidation effect caused by waste metal ions.
(3) Carnosine can protect telomeres, slow down the rate-shortening function of the telomeres and prolong the service life of cells.
In a preferred embodiment of the present invention, the β -glucan is derived from Schizophyllum commune and is a polysaccharide containing β -1,3 glycosidic linkages and β -1,6 glycosidic linkages.
The β -glucan of the invention belongs to a Schizophyllum commune source and contains polysaccharide with β -1,3 and β -1,6 glycosidic bonds, wherein the research on the β -1,6 glycosidic bonds exceeds that of β -1,3 glycosidic bonds, the functional activity of the polysaccharide is stronger than that of β -1,3 glycosidic bonds, and the polysaccharide can effectively improve the level of humoral IL-1 β, IL-6, IL-8 and TNF- α immune factors, the Schizophyllum commune source β -glucan has the functions of improving the level of skin immune factors, increasing the number of skin immune cells, improving the immune capacity of humoral, resisting allergy, eliminating tissue edema and inflammation, scavenging free radicals and ultraviolet rays, accelerating the repair of the skin after sunburn, resisting infection caused by filterable viruses, fungi, bacteria and the like, controlling cell division and differentiation, regulating cell growth, slowing down skin aging, promoting the production of collagen and preventing wrinkles, and providing natural factors for maintaining moisture.
As a preferred embodiment of the invention, the composition capable of enhancing the night repair and regeneration capacity of the skin provided by the invention comprises the following components in percentage by mass:
the balance of a cosmetic or dermatologically common external preparation matrix and/or water;
the active ingredients of the compound composition A are Mirabilis jalapa extract and caffeine;
the active components of the composite composition B are complex enzyme and lecithin, and the complex enzyme comprises endonuclease, guanine glycosylase and thioredoxin.
The sodium hyaluronate selected by the invention is obtained by screening sodium hyaluronate with different molecular weights through a large number of in vivo experiments, is an integrated sodium hyaluronate with a full-waveband biotechnology form, and has the effects of rapid penetration and rapid moisture preservation. Can promote the health of epidermis, increase skin elasticity and smoothness, reduce wrinkle, and promote the production of elastin.
As a preferred embodiment of the invention, the composition capable of enhancing the night repair and regeneration capacity of the skin provided by the invention comprises the following components in percentage by mass:
the balance of a cosmetic or dermatologically common external preparation matrix and/or water;
the active ingredients of the compound composition A are Mirabilis jalapa extract and caffeine;
the active components of the composite composition B are complex enzyme and lecithin, and the complex enzyme comprises endonuclease, guanine glycosylase and thioredoxin.
The cosmetic or dermatological base for external preparations may be one commonly used for external preparations that can be applied to cosmetics or dermatology, known to those skilled in the art, and may be cosmetically or pharmaceutically acceptable, such as one or more of solvents, solubilizers, preservatives, antioxidants, pH regulators, penetration enhancers, liposomes, humectants, thickeners, chelating agents, skin feel regulators, surfactants, emulsifiers, propellants/propellants, fragrances, pigments, and other efficacy additives.
In another aspect, the invention also provides the application of the composition capable of enhancing the night repair and regeneration capacity of the skin in preparing medicines and/or cosmetics.
In addition, according to specific efficacy requirements, other corresponding active ingredients can be added into the medicine and/or the cosmetics to achieve the target effect.
The dosage form of the medicine and/or the cosmetic is cream, emulsion, gel or aqua.
The composition of the invention can be directly applied to the skin surface, and can also be further used for producing cosmetics or medicaments to be applied to the skin surface.
Compared with the prior art, the invention has the following beneficial effects:
according to the invention, through the compounding of a plurality of active ingredients such as the compound composition A, the compound composition B, carnosine, sodium hyaluronate, β -glucan and the like, the cell life is effectively prolonged, the night repair and regeneration capability of skin cells are promoted, the protective capability of the cells is improved, and the bioavailability of all active ingredients provided for the skin can be increased and the overall efficacy of the composition is effectively improved through various action mechanisms such as accelerating DNA night repair, reducing and eliminating free radicals, accelerating the metabolic level of skin cells, protecting telomeres and the like.
Drawings
FIG. 1 is a graph showing the results of comparison between example 8 and control 2.
FIG. 2 is a graph showing the results of comparison between example 8 and control 2.
FIG. 3 is a graph of Ue and Ur after using example 8 in comparison with control 2.
FIG. 4 is a graph showing a comparison between before and after use of example 12 and control 3.
Detailed Description
According to the invention, through compounding of a plurality of active ingredients such as the compound composition A, the compound composition B, carnosine, sodium hyaluronate, β -glucan and the like, the night repair and regeneration capabilities of skin are effectively enhanced, and the night repair and regeneration capabilities are specifically shown as enhancing the skin metabolic capability, repairing and improving the skin barrier, improving the skin water-locking capability, helping the skin to recover the health condition, improving the skin elasticity, water wettability and smoothness, and enhancing the oxidation resistance and anti-aging capability of the skin.
The present invention will be described in further detail with reference to specific examples, but the embodiments of the present invention are not limited thereto.
A composition capable of enhancing night repair and regeneration capacity of skin comprises the following components in percentage by mass:
the balance of a cosmetic or dermatologically common external preparation matrix and/or water;
the active ingredients of the compound composition A are Mirabilis jalapa extract and caffeine;
the active components of the composite composition B are complex enzyme and lecithin, and the complex enzyme comprises endonuclease, guanine glycosylase and thioredoxin.
In the invention, each component can be a commercial product or can be prepared according to the record of the prior art, and each extract meets the requirements of related quality standards.
Example 1
Night repair essence:
a night repair essence containing a composition capable of enhancing night repair and regeneration capacity of skin comprises the following components in percentage by mass:
water phase:
low temperature addition (40 ℃ C.)
The night repair essence is prepared by respectively heating water phase to 80 deg.C, homogenizing, stirring, cooling to 40 deg.C, adding composite composition A, composite composition B, carnosine, sodium hyaluronate, β -dextran, and antiseptic, stirring, and cooling to 35 deg.C to obtain white fluid essence.
The composite composition a is a commercially available product, and includes mirabilis jalapa extract and caffeine, and is a transparent suspension with cells, which is merely exemplary and not limiting.
The composite composition B is a commercial product, active ingredients of the composite composition B are composite enzyme and lecithin, the composite enzyme comprises endonuclease, guanine glycosylase and thioredoxin, the composite enzyme is derived from extracts of chlorella and haematococcus pluvialis, is a milky white liquid, and the composite enzyme is only an example and is not limited, and the following is the same.
Carnosine is a commercially available product in the form of white powder, which is merely exemplary and not limiting herein.
The sodium hyaluronate is a product sold on the market, is hyaluronic acid from biological fermentation, is obtained by screening hyaluronic acid with different molecular weights through a large number of in vivo experiments, and is the same as the product below.
β -Glucan is a commercially available product from Ningpo Schinoya Bio Inc. and is a Schizophyllum commune-derived polysaccharide containing β -1,3 and β -1,6 glycosidic linkages, and is provided herein by way of example and not by way of limitation, as follows.
Example 2
Repairing water at night:
the night repair water containing the composition capable of enhancing the night repair and regeneration capacity of the skin comprises the following components in percentage by mass:
water phase:
low temperature addition (40 ℃ C.)
The night rehabilitation water is prepared by respectively heating water phase to 80 deg.C, homogenizing, stirring, cooling to 40 deg.C, adding composite composition A, composite composition B, carnosine, sodium hyaluronate, β -dextran, and antiseptic, stirring, and cooling to 35 deg.C to obtain white fluid.
Example 3
Night repair milk:
a night repair emulsion containing a composition capable of enhancing night repair and regeneration capacity of skin comprises the following components in percentage by mass:
oil phase:
water phase:
low temperature addition after emulsification (40 ℃ C.)
The night repair emulsion is prepared by heating oil phase and water phase to 80 deg.C respectively, mixing the two phases, homogenizing for several minutes, stirring, cooling to 40 deg.C, adding composite composition A, composite composition B, carnosine, sodium hyaluronate, β -dextran, essence and antiseptic, stirring, and cooling to 35 deg.C to obtain white fine uniform emulsion.
Example 4
Night repair cream:
a night repair cream containing a composition capable of enhancing night repair and regeneration of skin comprises the following components in percentage by mass:
oil phase:
water phase:
low temperature addition after emulsification (40 ℃ C.)
The night repair cream is prepared by heating oil phase and water phase to 80 deg.C respectively, mixing the two phases, homogenizing for several minutes, stirring, cooling to 40 deg.C, adding composite composition A, composite composition B, carnosine, sodium hyaluronate, β -dextran, essence and antiseptic, stirring, and cooling to 35 deg.C to obtain white fine uniform cream.
Example 5
Night repair cream:
a night repair cream containing a composition capable of enhancing night repair and regeneration of skin comprises the following components in percentage by mass:
oil phase:
water phase:
low temperature addition after emulsification (40 ℃ C.)
The night repair cream is prepared by heating oil phase and water phase to 80 deg.C respectively, mixing the two phases, homogenizing for several minutes, stirring, cooling to 40 deg.C, adding composite composition A, composite composition B, carnosine, sodium hyaluronate, β -dextran, essence and antiseptic, stirring, and cooling to 35 deg.C to obtain white fine uniform cream.
Example 6
Night repair milk:
a night repair emulsion containing a composition capable of enhancing night repair and regeneration capacity of skin comprises the following components in percentage by mass:
oil phase:
water phase:
low temperature addition after emulsification (40 ℃ C.)
The night repair emulsion is prepared by heating oil phase and water phase to 80 deg.C respectively, mixing the two phases, homogenizing for several minutes, stirring, cooling to 40 deg.C, adding composite composition A, composite composition B, carnosine, sodium hyaluronate, β -dextran, essence and antiseptic, stirring, and cooling to 35 deg.C to obtain white fine uniform emulsion.
Example 7
Night repair milk:
a night repair emulsion containing a composition capable of enhancing night repair and regeneration capacity of skin comprises the following components in percentage by mass:
oil phase:
water phase:
low temperature addition after emulsification (40 ℃ C.)
The night repair emulsion is prepared by heating oil phase and water phase to 80 deg.C respectively, mixing the two phases, homogenizing for several minutes, stirring, cooling to 40 deg.C, adding composite composition A, composite composition B, carnosine, sodium hyaluronate, β -dextran, essence and antiseptic, stirring, and cooling to 35 deg.C to obtain white fine uniform emulsion.
Example 8
Night repair cream:
a night repair cream containing a composition capable of enhancing night repair and regeneration of skin comprises the following components in percentage by mass:
oil phase:
water phase:
low temperature addition after emulsification (40 ℃ C.)
The night repair cream is prepared by heating oil phase and water phase to 80 deg.C respectively, mixing the two phases, homogenizing for several minutes, stirring, cooling to 40 deg.C, adding composite composition A, composite composition B, carnosine, sodium hyaluronate, β -dextran, essence and antiseptic, stirring, and cooling to 35 deg.C to obtain white fine uniform cream.
Example 9
Night repair essence:
a night repair essence containing a composition capable of enhancing night repair and regeneration capacity of skin comprises the following components in percentage by mass:
water phase:
low temperature addition (40 ℃ C.)
The night repair essence is prepared by respectively heating water phase to 80 deg.C, homogenizing, stirring, cooling to 40 deg.C, adding composite composition A, composite composition B, carnosine, sodium hyaluronate, β -dextran, and antiseptic, stirring, and cooling to 35 deg.C to obtain white fluid essence.
Example 10
Observation on trial
The night repair milks prepared in examples 6 to 7 of the present invention and control 1 were used to observe the effect of moisturizing.
Sample preparation: examples 6 to 7
Control 1 composite composition A, composite composition B, carnosine, sodium hyaluronate, and β -dextran from example 6 were removed.
Example 11
The night repair cream prepared in the embodiment 8 of the invention and the control sample 2 are adopted to observe the curative effect of skin elasticity and wrinkle reduction.
Sample preparation: example 8
Control 2 composite composition A, composite composition B, carnosine, sodium hyaluronate, β -dextran of example 8 were removed.
Example 12
The night repair essence prepared in the embodiment 9 of the invention and the control sample 3 are used for observing the curative effect of improving the skin color.
Sample preparation: example 9
Control 3 Complex composition A, Complex composition B, carnosine, sodium hyaluronate, β -dextran from example 9 were removed.
Specific comparative experiment
1. Contrast experiment, moisturizing Performance test
20 volunteers, female volunteers aged 18 to 50 years, in an indoor environment at 20 ℃ and 50% relative humidity, a fixed area of 2CM square was drawn at the forehead, and after using the sample and the control mentioned in example 10 in the fixed area, skin moisture change data (mean values are shown below) were obtained by integrating the skin moisture change data, and the test results are shown in the following table:
table 1 moisturizing performance test
As can be seen from the above table, the moisturizing effect of the repair cream containing the composition of the present invention is better than that of the control sample without adding, and the moisturizing effect is better as the addition amount is higher.
2. And (3) comparison test: wrinkle-reducing effect
The using method comprises the following steps: the left and right half faces are applied for 2 times every day, and the dosage is that the face is uniformly applied.
After 28 days of use, the skin started to become moist, smooth, and restored luster and elasticity, with 27 (77%) volunteers feeling better lightening of the crow's feet in example 8 than control 2, and 25 (71%) volunteers feeling significantly better lightening of the wrinkles in the night repair cream of test example 8 than control 2, as shown in fig. 1 and 2.
3. And (3) comparison test: skin elasticity measurement
30 volunteers marked the 4X 4cm2 test area on the inner side of the forearm of the left and right hand, respectively, and the same arm marked 2 areas at the same time, with the intervals of 2 cm. Measurements of the test area and the control area were performed using a CK skin elasticity tester, each area being measured 3 times according to a parallel. The blank value for each test area was measured and then the sample was evenly spread into the test area using a latex finger cuff at a rate of 2.0 + -0.1 mg sample/cm 2. After 28 days of application, the skin elasticity of the test area and the blank control area was measured.
Human body detection results show that: the night repair cream of example 8 and control 2 were used for 28 days, while the skin elasticity was improved to various degrees, but the elasticity parameter Ue (elastic deformation) and the elasticity parameter Ur (recovery after elastic deformation) in the anti-aging cream of example 8 were higher than those of the blank control of control 2, with numerical increases of 11.4% and 13.4%, respectively, as shown in fig. 3.
4. Comparative experiment: skin color improving effect
The night repair essence of example 9 and the control 3 of example 12 were used clinically for 28 days in 35 volunteers. The clinical staff age is 35-50 years old. The face of 35 people has dark and uneven skin color in different degrees.
The using method comprises the following steps: the left and right half faces are applied for 2 times every day, and the dosage is that the face is uniformly applied.
After 28 days of use, the skin tone started to become shiny, more uniform than when the product was not used. Of these, 25 (71%) volunteers felt that the night repair essence of example 9 had better effects on skin color adjustment and spot lightening than the blank control, 23 (65%) considered that the night repair essence of example 9 had more even skin color after use, and 26 (74%) volunteers felt that the night repair essence of example 9 could increase skin glossiness, as shown in fig. 4.
Of course, the principle and the implementation of the present invention are explained in the following by using specific examples, and the above description of the embodiments is only used to help the method and the core idea of the present invention. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
Claims (8)
1. A composition capable of enhancing night repair and regeneration capacity of skin is characterized by comprising the following components in percentage by mass:
the balance of a cosmetic or dermatologically common external preparation matrix and/or water;
the active ingredients of the compound composition A are Mirabilis jalapa extract and caffeine;
the active components of the composite composition B are complex enzyme and lecithin, and the complex enzyme comprises endonuclease, guanine glycosylase and thioredoxin.
2. The composition for enhancing night repair and regeneration of skin according to claim 1, wherein the composition comprises the following components by mass percent:
the balance of a cosmetic or dermatologically common external preparation matrix and/or water;
the active ingredients of the compound composition A are Mirabilis jalapa extract and caffeine;
the active components of the composite composition B are complex enzyme and lecithin, and the complex enzyme comprises endonuclease, guanine glycosylase and thioredoxin.
3. The composition for enhancing night repair and regeneration of skin according to claim 2, wherein the composition comprises the following components by mass percent:
the balance of a cosmetic or dermatologically common external preparation matrix and/or water;
the active ingredients of the compound composition A are Mirabilis jalapa extract and caffeine;
the active components of the composite composition B are complex enzyme and lecithin, and the complex enzyme comprises endonuclease, guanine glycosylase and thioredoxin.
4. The composition for enhancing night repair and regeneration of skin according to any one of claims 1 to 3, wherein the complex composition A further comprises glycerin, and the complex composition A is prepared by combining 79 parts by weight of glycerin, 20 parts by weight of Mirabilis jalapa extract and 1 part by weight of caffeine.
5. The composition for enhancing night repair and regeneration of skin according to any one of claims 1 to 3, wherein the composite composition B comprises the following components in percentage by mass: 2-4% of complex enzyme, 0.2-5.5% of lecithin and the balance of water; the compound enzyme is derived from extracts of chlorella and haematococcus pluvialis.
6. The composition of any one of claims 1 to 3, wherein said β -glucan is derived from Schizophyllum commune and is a polysaccharide having β -1,3 glycosidic linkages and β -1,6 glycosidic linkages.
7. Use of a composition according to any one of claims 1 to 3 for enhancing the nighttime skin repair, regeneration capacity in the preparation of a medicament and/or a cosmetic.
8. Use according to claim 7, characterized in that the pharmaceutical and/or cosmetic formulation is in the form of a cream, emulsion, gel or aqueous preparation.
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Application publication date: 20200612 |