CN111228414A - 改善男性性功能的保健食品或中药复方及超声波制备方法 - Google Patents
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Abstract
本发明公开了改善男性性功能的保健食品或中药复方及超声波制备方法,属于中药复方制剂或者保健食品技术领域。本发明提出一种配伍科学严谨、药效高,能有效提高***质量、改善亚健康状况的中药复方组合物和保健食品配方,包括仙茅、仙灵脾、杜仲、巴戟天、黄芪、当归、牛膝、党参、炒白术、茯苓等中药或者药食两用成分。本发明中的配方能缩短小鼠交配潜伏期,20min内交配次数明显增加,同时可显著增加雄性小鼠附性器官重量,提高雄性小鼠血清的一氧化氮(NO)和睾酮浓度,本发明配方具有显著的改善性功能作用。
Description
技术领域
本发明涉及中药复方制剂或者保健食品技术领域,具体涉及一种改善男性性功能及抗疲劳的中药组合物或者保健食品及超声波制备方法。
背景技术
近年来,随着社会和经济的不断发展,人类对生活质量的要求越来越高,生活节奏的加快以及生活压力的增大,同时环境污染的加剧,男性生殖健康问题越来越突出,男性的一些疾病与不良嗜好如***炎、嗜烟嗜酒、缺乏运动以及药物的使用等导致男性性功能障碍呈明显上升趋势。男子性功能障碍是指男性性功能和性满足无能,常表现为***障碍、阳痿、早泄、遗精、不***和逆行***等。性行为既是本能的更是以精神心理活动为基础的生理活动,因而男子性功能障碍除部分因全身疾病和生殖***疾病等器质性病变所致。性功能障碍在给患者带来心理压力的同时,直接影响患者的生活质量,从而可能影响原发疾病的治疗,所以应当引起临床重视(药物致男性性功能障碍,中国医院药学杂志2001年第21卷第12期)。
另外除了男性性功能障碍以外,***品质也是男性生殖技能的重要环节,而***异常所致的***约占70%~80%。***异常性不育症包括无精、少精、死精、***活动力低及精不液化、***畸形等六种症候。其原因包括睾丸发育异常、染色体异常、***发生功能障碍和局部病变(隐性***,巨大鞘膜积液等疾病)等。
目前西医针对明确的病因或者针对单一病变组织施治有较好效果,而大部分人并不能找到直接原因,因此还需要调养进行辅助治疗。并且西药治疗性功能障碍比较常用,效果要比中药治疗的效果好一些,但是西药的副作用是比较大的,例如可能会诱发心血管事件,视力障碍,头晕,面部潮红,恶心……等。采取中药治疗性功能障碍最为常用,中药有着良好的药理作用,目前中医调养基本为壮阳补肾固精的方法,很多壮阳补肾的中草药属于药食同源植物,很多地区都有作为食物使用的传统,没有毒副作用。目前,虽然已经有提高男性性功能和***品质的药物或者配合制剂出现,但是由于中药复方的成分多样,目前的制备方法,仅仅是热水或者乙醇浸提,并不能将中药成分中活性成分全部提取出来,因此导致得到中药复方制剂效益低,或者需要更长的服药时间。因此需要除了研究合适中药复方意外,还需要开发相应的高效绿色制备方法。
超声波是频率为2×104Hz~109Hz的声波,是物体机械振动状态(或能量)的传播形式,其传播频率较高,波长短,传播特异性强,介质振动强度大是其主要特点。现在一般按照超声波的用途,将其分为检测超声和功率超声两大类超声,其中功率超声处理是利用超声振动能量改变或加速物质物理状态、化学性质、生物特性和功能的技术,广泛应用于工业、农业和医药领域。目前超声处理技术在中药加工方面的应用主要是超声促进生物体内活性成分的提取,它在促进中药材原料有效成分的提取方面有独特的优势,这方面研究很多,如对黄酮、多糖和一些生物活性物质的提取等,超声处理技术的应用使得提取效率提高。
发明内容
本发明的目的是为了弥补现有技术的不足,提供一种配方科学、安全可靠,能有效提高***质量、抗疲劳的中药组合物和保健食品以及超声波制备方法。
以上所述中药组合物采用的技术方案如下:
一种改善男性性功能及抗疲劳的中药组合物,由以下重量份数的中药材制备而成:
上述中药材中仙灵脾(10~20份)也可以用锁阳(10~20份)代替。
上述中药材中仙灵脾(10~20份)也可以用紫河车(10~20份)代替,鹿角片(10~20份)用龟甲片(10~20份)代替。
其中所述的杜仲为炒杜仲,将生杜仲用盐水淋喷拌匀,待吸尽,再用文火炒至黄褐色入药。
其中所述的黄芪为蜜炙黄芪,黄芪片用蜂蜜拌匀,炒至不粘手时取出摊晾,而后入药的。
其中所述的甘草为炙甘草。
一种改善男性性功能及抗疲劳的中药组合物,优选由以下重量份数的原料制备而成:
上述中药材中仙灵脾(15份)也可以用锁阳(15份)代替。
上述中药材中仙灵脾(15份)也可以用紫河车(15份)代替,鹿角片(15份)用龟甲片(15份)代替。
上述一种改善男性性功能及抗疲劳的中药组合物的制备方法,按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过80~100目筛后,充分混合。
(2)按1:10~20(m/v)加入自来水或者矿泉水,在60~70℃温度下使用多模式超声波提取仪进行浸提。浸提结束后倒去上清液并加入等量的自来水或者矿泉水,重复此浸提过程1轮。合并浸提液过滤除杂,滤液经真空浓缩,冷冻干燥制得中药组合物。
其中步骤(2)所述的提取溶剂除了自来水或者矿泉水以外,也可以使用体积分数为40-70%的乙醇-水溶液。
其中步骤(2)所述多模式超声波提取的具体参数为超声时间10min-40min,优选超声时间为30min;超声功率60W/L-180W/L,优选超声功率为150W;超声频率20kHz、28kHz、35kHz、40kHz、60kHz,或者其两两组合,或者其三三组合,优选超声频率35kHz/60kHz或者20kHz/35kHz/60kHz。
上述一种改善男性性功能及抗疲劳的中药组合物的制备方法,或者按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过80~100目筛后,
(2)每种原料按1:10~20(m/v)加入自来水或者矿泉水,在60~70℃温度下使用多模式超声波提取仪进行浸提。浸提结束后倒去上清液并加入等量的自来水或者矿泉水,重复此浸提过程1轮;合并浸提液过滤除杂,滤液经真空浓缩,喷雾干燥或者冷冻干燥制得到单味中药提取物,然后按照上述原料的比例混合即可得到中药组合物。
其中步骤(2)所述的提取溶剂除了自来水或者矿泉水以外,也可以使用体积分数为40-70%的乙醇-水溶液。
其中步骤(2)所述多模式超声波提取的具体参数为超声时间10min-40min,优选超声时间为30min;超声功率60W/L-180W/L,优选超声功率为150W;超声频率20kHz、28kHz、35kHz、40kHz、60kHz,或者其两两组合,或者其三三组合,优选超声频率35kHz/60kHz或者20kHz/35kHz/60kHz。
本发明所述的改善男性性功能及抗疲劳的中药组合物的制品可为固体饮料粉末、口服液、丸剂、片剂、散剂、颗粒剂、胶囊、丹剂或汤剂。
一种改善男性性功能及抗疲劳的保健食品,由以下重量份数的中药材制备而成:
其中所述的杜仲为炒杜仲,将生杜仲用盐水淋喷拌匀,待吸尽,再用文火炒至黄褐色入药。
其中所述的黄芪为蜜炙黄芪,是黄芪片用蜂蜜拌匀,炒至不粘手时取出摊晾,而后入药的。
其中所述的甘草为炙甘草。
一种改善男性性功能及抗疲劳的保健食品,优选由以下重量份数的原料制备而成:
上述一种改善男性性功能及抗疲劳的保健食品的制备方法,按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过80~100目筛后,充分混合。
(2)按1:10~20(m/v)加入自来水或者矿泉水,在60~70℃温度下使用多模式超声波提取仪进行浸提。浸提结束后倒去上清液并加入等量的自来水或者矿泉水,重复此浸提过程1轮。合并浸提液过滤除杂,滤液经真空浓缩,喷雾干燥或者冷冻干燥制得中药组合物。
其中步骤(2)所述的提取溶剂除了自来水或者矿泉水以外,也可以使用体积分数为40-70%的乙醇-水溶液。
其中步骤(2)所述多模式超声波提取的具体参数为超声时间10min-40min,优选超声时间为30min;超声功率60W/L-180W/L,优选超声功率为150W;超声频率20kHz、28kHz、35kHz、40kHz、60kHz,或者其两两组合,或者其三三组合,优选超声频率35kHz/60kHz或者20kHz/35kHz/60kHz。
上述一种改善男性性功能及抗疲劳的保健食品的制备方法,或者按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过80~100目筛后,
(2)每种原料按1:10~20(m/v)加入自来水或者矿泉水,在60~70℃温度下使用多模式超声波提取仪进行浸提。浸提结束后倒去上清液并加入等量的自来水或者矿泉水,重复此浸提过程1轮;合并浸提液过滤除杂,滤液经真空浓缩,喷雾干燥或者冷冻干燥制得到单味中药提取物,然后按照上述原料的比例混合即可得到中药组合物。
其中步骤(2)所述的提取溶剂除了自来水或者矿泉水以外,也可以使用体积分数为40-70%的乙醇-水溶液。
其中步骤(2)所述多模式超声波提取的具体参数为超声时间10min-40min,优选超声时间为30min;超声功率60W/L-180W/L,优选超声功率为150W;超声频率20kHz、28kHz、35kHz、40kHz、60kHz,或者其两两组合,或者其三三组合,优选超声频率35kHz/60kHz或者20kHz/35kHz/60kHz。
本发明所述的改善男性性功能及抗疲劳的保健食品的可为固体饮料粉末、口服液、丸剂、片剂、散剂、颗粒剂、丹剂、胶囊或汤剂。
本发明所述主要中药成分的各组分的功效作用如下:
菟丝子、枸杞子、茯苓作为药食同源原料,具有坚筋骨、通血脉、补中益气、益肾缩尿、益精健阳和养肝明目等功效。其中菟丝子和枸杞子作为治疗***不育的古方——五子衍宗丸的重要组成成分,具有治疗肾精亏虚导致的男子阳痿、不育、遗精、早泄和腰痛等病症的功效。
仙茅(学名:Curculigo orchioides Gaertn.),又名地棕(四川、贵州),独茅(四川),山党参(福建),仙茅参(云南),海南参(海南),茅爪子,婆罗门参,属仙茅科,花期4~9月。温肾阳壮;祛除寒湿。主阳萎精冷;小便失禁;脘腹冷痛;腰膝酸痛;筋骨软弱;下肢拘挛;更年期综合征。
仙灵脾又叫刚前、淫羊藿、仙灵毗、放杖草、千两金、干鸡筋、黄连祖、三枝九叶等。小檗科植物箭叶淫羊藿Epimedium sagittatum(Sieb.et Zucc.)Maxim.或淫羊藿E.brevicornum Maxim.等的全草。有补肾壮阳、祛风除湿、强筋健骨的功效,仙灵脾有治疗阳痿遗精、虚冷不育、尿频失禁、肾虚喘咳、腰膝酸软、风湿痹痛、半身不遂、四肢不仁的作用。
杜仲(学名:Eucommia ulmoides Oliver)的功用主治是:补肝肾,强筋骨,安胎。治腰膝酸疼,足膝痿弱,小便余沥,阴下湿痒,胎漏欲堕,胎动不安,高血压。一般中药单味药效果不明显,都是配伍使用的。杜仲食疗作用:该品味甘、微辛,性温。归肝、肾经。气和润降。能补肝肾,强筋骨,安胎。主治腰膝酸痛,阳痿,遗精,尿频,小便余沥,阳亢眩晕,风湿痹痛,阴下湿痒,胎动不安,漏胎小产。生杜仲:是将原药洗净,刷去粗皮,厚薄分开,切成宽条晾干即可,与熟杜仲的主要区别是表面淡棕色,较平滑,内表面光滑,质脆易折断,断面有银白色丝状物相连,细密,略有伸缩性,味淡;降血压的作用好。熟杜仲:是指炒杜仲,为生杜仲用盐水淋喷拌匀,待吸尽,再用文火炒至黄褐色入药。与生杜仲的主要区别是表面色偏深,有焦斑,断面有银白色丝状物易断,几无伸缩性,味咸;熟杜仲用盐炒,有引经入肾之说,其补肾的功效更好。本发明中杜仲为炒杜仲。
巴戟天(学名:Morinda officinalis How)主产于广东、广西等地,主治阳痿遗精、宫冷***、***、少腹冷痛、风湿痹痛、筋骨痿软。(属于卫计委公布的可用于保健食品的中药名单)
黄芪是黄耆的根,黄耆(学名:Astragalus propinquus Schischkin)是豆科黄耆属植物,味甘,性微温,具补气固表、利尿、强心、降压、抗菌、托毒、排脓、生肌、加强毛细血管抵抗力、止汗和类性激素的功效,治表虚自汗、气虚内伤、脾虚泄泻、浮肿及痈疽等。本发明使用的是蜜炙黄芪,又称蜜黄芪或者炙黄芪。也就是黄芪片用蜂蜜拌匀,炒至不粘手时取出摊晾,而后入药的。蜜黄芪一般为圆形或椭圆形的片,具蜜香气,味甜,略带黏性,放入口中嚼咬会微微有豆腥味。经过了蜂蜜炒制后,增强了黄芪的补气润肺功效。蜜黄芪的功效与作用与黄芪大致相同,所以,蜜黄芪可以益气补中、用于气虚乏力,食少便溏。补火助阳,引火归源,散寒止痛,活血通经。适宜用于阳痿、宫冷、心腹冷痛、虚寒吐泻、经闭、痛经、温经通脉。
当归为伞形科植物当归Angelica sinensis(Oliv、)Diels的干燥根。秋末采挖,除去须根及泥沙,待水分稍蒸发后,捆成小把,上棚,用烟火慢慢熏干。全当归根略呈圆柱形,根上端称“归头”,主根称“归身”或“寸身”。支根称“归尾”或“归腿”,全体称“全归”。具有补血;活血;调经止痛;润燥滑肠。主血虚诸证;***;经闭;痛经;症瘕结聚;崩漏;虚寒腹痛;痿痹;肌肤麻木;肠燥便难;赤痢后重;痈疽疮疡;跌扑损伤等功效。
牛膝别名:牛磕膝,拉丁文名:Achyranthes bidentata Blume.苋科、牛膝属多年生草本。根入药,生用,活血通经;治产后腹痛,***,闭经,鼻衄,虚火牙痛,脚气水肿;熟用,补肝肾,强腰膝;治腰膝酸痛,肝肾亏虚,跌打瘀痛。本发明中淮牛膝或者川牛膝都可以达到效果。
党参(学名;Codonopsis pilosula(Franch.)Nannf.)桔梗科党参属,多年生草本植物,有乳汁。茎基具多数瘤状茎痕,根常肥大呈纺锤状或纺锤状圆柱形。党参为中国常用的传统补益药,古代以山西上党地区出产的党参为上品,具有补中益气,健脾益肺之功效。党参有增强免疫力、扩张血管、降压、改善微循环、增强造血功能等作用。此外对化疗放疗引起的白细胞下降有提升作用。
白术(学名:Atractylodes macrocephala Koidz.):菊科苍术属多年生草本植物,高可达60厘米,结节状根状茎。白术苦、甘,温。健脾益气,燥湿利水,止汗,安胎。用于脾虚食少,消化不良,泄泻,水肿,自汗,胎动不安。炒白术是一种补虚药,具有健脾益气等效果,是将蜜炙麸皮撒入热锅内,待冒烟时加入白术片,炒至焦黄色、逸出焦香气,取出,筛去蜜炙麸皮。每100kg白术片,用蜜炙麸皮10kg。
茯苓,为多孔菌科真菌茯苓Poria cocos(Schw.)Wolf的干燥菌核。多于7~9月采挖,挖出后除去泥沙,堆置“发汗”后,摊开晾至表面干燥,再“发汗”,反复数次至现皱纹、内部水分大部散失后,阴干,称为“茯苓个”;或将鲜茯苓按不同部位切制,阴干,分别称为“茯苓块”和“茯苓片”。具有利水渗湿,健脾,宁心的功效。用于水肿尿少,痰饮眩悸,脾虚食少,便溏泄泻,心神不安,惊悸失眠。
桂枝,属樟目,樟科中等大乔木。春、夏季剪下嫩枝,晒干或阴干,切成薄片或小段用。辛、甘,温。归心、肺、膀胱经。具有发汗解肌,温通经脉,助阳化气,平冲降气的功效。常用于风寒感冒,脘腹冷痛,血寒经闭,关节痹痛,痰饮,水肿,心悸等。
白芍(学名:Paeonia lactiflora Pall)也称白花芍药,是芍药科芍药属植物。在中国已有悠久的栽培历史,驰名中外,其称白花芍药。多年生草本或亚灌木,生于山坡、山谷的灌木丛或草丛中。我国大部分地区均有栽植。白芍的功效:养血柔肝,缓中止痛,敛阴收汗。治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,***,崩漏,带下。炒白芍是一种药物,为毛茛科植物芍药PaeonialactifloraPall.的干燥根,呈圆柱形,平直或稍弯曲,两端平截,长5~18cm,直径1~2.5cm。表面类白色或淡红棕色,平肝止痛,养血调经,敛阴止汗。用于头痛眩晕,胁痛,腹痛,四肢挛痛,血虚萎黄,***,自汗,盗汗,出自《中国药典》。
菟丝子(学名:Cuscuta chinensis Lam.),别名禅真、豆寄生、豆阎王、黄丝、黄丝藤、金丝藤等。一年生寄生草本。菟丝子是一味平补肾、肝、脾之良药,临床主要应用于肾虚腰痛、阳痿遗精、尿频、宫冷***、目暗便溏之肾阴阳虚证。菟丝子甘、温,归肾、肝、脾经,具有滋补肝肾、固精缩尿、安胎、明目、止泻之功效,始载《神农本草经》,被列为上品。甘味一般具有滋补作用,甘辛微温,禀气中和,既可补阳,又可益阴,具有温而不燥,补而不滞的特点。固精安胎与性激素样作用。
枸杞子,为茄科植物枸杞的成熟果实。夏、秋果实成熟时采摘,除去果柄,置阴凉处晾至果皮起皱纹后,再暴晒至外皮干硬、果肉柔软即得。枸杞,又称枸杞子、红耳坠,是茄科小灌木枸杞的成熟子实。枸杞子药食同源的历史悠久,是驰名中外的名贵中药材,早在《神农本草经》中就被列为上品,称其为“久服轻身不老、耐寒暑”;有延衰抗老的功效,又名“却老子”。枸杞子中含有多种氨基酸,并含有甜菜碱、玉蜀黍黄素、酸浆果红素等特殊营养成分,使其具有非常好的保健功效。适合所有人食用。用眼过度者及老人更加适合。枸杞性质比较温和,食用稍多无碍,但若毫无节制,进食过多也会令人上火。
鹿角片具有补肾阳、益精血、强筋骨、行血消肿等功效,主治肾虚腰脊冷痛、阳痿遗精、崩漏、白带、尿频尿多、阴疽疮疡、乳痈肿痛、跌打瘀肿、筋骨疼痛等症状。
淮小麦因主产于江淮地区的小麦,称淮小麦。味甘,性凉,能够敛汗,止汗,益气,养心,除热,无论是阳虚的自汗还是阴虚的盗汗都可以使用。淮小麦还能益气养阴和除热,对于阴虚发热和骨蒸劳热的病症也有一定的治疗作用。淮小麦可以养人体先天之本的肾,也能养后天之本的脾胃,能健脾胃益肾,是一很好的养生保健食品。
甘草(学名:Glycyrrhiza uralensis Fisch)别名:国老、甜草、乌拉尔甘草、甜根子。豆科、甘草属多年生草本,根与根状茎粗壮,是一种补益中草药。药用部位是根及根茎,具有补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药之功效。常用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
炙甘草是用蜜烘制的甘草,俗称炮制,就是将蜂蜜置锅中炼成中蜜,改用文火加生甘草片拌炒均匀,3~5min出锅,置烤房或烘箱60℃烘至不粘手时取出,放凉即可。炙甘草为类圆形或椭圆形切片,表面红棕色或灰棕色,微有光泽,切面黄色至深黄色,形成层环明显,射线放射状。炙甘草汤具有益气滋阴,通阳复脉治疗功效。
陈皮,为芸香科植物橘Citrus reticulata Blanco及其栽培变种的干燥成熟果皮。采摘成熟果实,剥取果皮,晒干或低温干燥。理气健脾,燥湿化痰。用于脘腹胀满,食少吐泻,咳嗽痰多。
地黄(拉丁学名:Rehmannia glutinosa(Gaetn.)Libosch.ex Fisch.et Mey.),玄参科地黄属多年生草本植物,高可达30厘米,根茎肉质,鲜时黄色,在栽培条件下,茎***。直径可达5.5厘米,叶片卵形至长椭圆形,叶脉在上面凹陷,花在茎顶部略排列成总状花序,花冠外***,内黄紫色,药室矩圆形,蒴果卵形至长卵形,花果期4-7月。熟地黄为玄参科植物地黄或怀庆地黄的根茎,经加工蒸晒而成。功能主治为:滋阴,补血。治阴虚血少,腰膝痿弱,劳嗽骨蒸,遗精,崩漏,***,消渴,溲数,耳聋。
锁阳(学名:Cynomorium songaricum Rupr.),锁阳科、锁阳属多年生肉质寄生草本,无叶绿素,全株红棕色,大部分埋于沙中。寄生根根上着生大小不等的锁阳芽体,初近球形,后变椭圆形或长柱形,具多数须根与脱落的鳞片叶。茎圆柱状,直立、棕褐色,埋于沙中的茎具有细小须根,茎基部略增粗或膨大。除去花序的肉质茎供药用(药材名:锁阳),能补肾、益精、润燥,主治阳痿遗精、腰膝酸软、肠燥便秘,对瘫痪和改善性机能衰弱有一定的作用。
紫河车,指人类的胎盘,中医认为,胎盘性味甘、咸、温,入肺、心、肾经,有补肾益精,益气养血之功。现代医学研究认为,胎盘含蛋白质、糖、钙、维生素、免疫因子、女性激素、助孕酮、类固醇激素、***、促肾上腺皮质激素等,能促进乳腺、子宫、***、睾丸的发育,对甲状腺也有促进作用,对肺结核、支气管哮喘、贫血等亦有良效。
龟甲片来源于龟科动物乌龟Chinemys reevesii(Gray)的背、腹甲。全年可采收,多在8月份后捕捉,捕后处死,剔除筋肉,取其甲,洗净晒干,称“血板”;煮后取甲称“烫板”。背甲长椭圆形拱状。外表面棕褐色或黑褐色,背棱3条,颈盾1块,前窄后宽,椎盾5块,肋盾两侧对称,各4块,缘盾每侧11块,臀盾2块。腹甲板片状,近长方状椭圆形,由12块角板对称嵌合而成。外表黄棕色或棕色,具紫褐色放射状斑纹。内表面黄白色至灰白色,有的略带血迹或残肉。质坚硬。气微腥,味微咸。性微寒,味咸、甘。归肝经、肾经、心经。具有滋阴潜阳、益肾强骨、养血补心等功效。属补虚药下属分类的补阴药。
本发明的有益效果在于:
(1)针对现有改善男性***质量药品或中药复方的不足,提出一种配伍科学严谨、药效高,能有效提高***质量、改善亚健康状况的中药复方组合物和保健食品配方。
(2)本发明在中药提取的过程中使用的物理方法为超声波处理。超声波是一种绿色环保的物理加工方式,在天然产物提取和食品工业中广泛应用,是制备中药复方提取物的一种新型物理处理方法;提取率提高15.1%~50.9%,时间缩短95%左右。
(3)本发明在保持提高***质量功效的基础上,利用不同中药或者药食两用活性组分间的协同效果,改善男性身体亚健康状况。小鼠动物试验表明,本发明中的配方能缩短小鼠交配潜伏期,20min内交配次数明显增加,同时可显著增加雄性小鼠附性器官重量,提高雄性小鼠血清的一氧化氮(NO)和睾酮浓度,本发明配方具有显著的改善性功能作用。
附图说明
图1是本发明的多模式超声波生物处理设备结构图,其中1、2、3为超声振板,4为盛液器,5为水浴锅,6为温度探头,7为循环泵,8为电脑程序控制器,9、10、11为超声控制器。
具体实施方式
在本发明中所使用的术语,除非有另外说明,一般具有本领域普通技术人员通常理解的含义。下面结合具体的实施例,并参照数据进一步详细地描述本发明。应理解,这些实施例只是对本发明进行进一步说明,不能理解为对本发明保护范围的限定,该领域的技术工程师可根据上述发明的内容对本发明作出一些非本质的改进和调整。
图1为本发明的多模式超声波生物处理设备,该设备配有一台电脑程序控制器8,可设定超声工作参数(超声功率密度、频率、脉冲工作时间、间歇时间和处理总时间)分别控制三个超声控制器9、10、11,分别连接三支不同频率的超声振板1、2、3,可实现单一频率/两个频率/三个频率超声波处理;将需要处理的溶液投入盛液器4中进行单频/双频/多频超声处理,启动循环泵7对溶液进行循环。通过水浴锅5和温度探头6实现溶液温度的自动控制。
在以下的实施例中,未详细描述的各种过程和方法是本领域中公知的常规方法。所用试剂的来源、商品名以及有必要列出其组成成分者,均在首次出现时标明,其后所用相同试剂如无特殊说明,均以首次标明的内容相同。
实施例1
一种改善男性性功能及抗疲劳的中药组合物,由以下重量份数的中药材制备而成:
杜仲为炒杜仲,将生杜仲用盐水淋喷拌匀,待吸尽,再用文火炒至黄褐色入药(下同)。
黄芪为蜜炙黄芪,也就是黄芪片用蜂蜜拌匀,炒至不粘手时取出摊晾,而后入药的(下同)。甘草为炙甘草(下同)。
上述一种改善男性性功能及抗疲劳的中药组合物的制备方法,按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过80目筛后,充分混合。
(2)按1:10(m/v)加入自来水,在60℃温度下使用多模式超声波提取仪进行浸提。多模式超声波提取的具体参数为超声时间10min,超声功率60W/L,超声频率35kHz/60kHz。浸提结束后倒去上清液并加入等量的自来水,重复此浸提过程1轮。合并浸提液过滤除杂,滤液经真空浓缩,冷冻干燥制得中药组合物。
实施例2
一种改善男性性功能及抗疲劳的中药组合物,由以下重量份数的中药材制备而成:
上述一种改善男性性功能及抗疲劳的中药组合物的制备方法,或者按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过100目筛后,
(2)每种原料按1:20(m/v)加入矿泉水,在70℃温度下使用多模式超声波提取仪进行浸提,多模式超声波提取的具体参数为超声时间40min,超声功率180W/L,超声频率60kHz。浸提结束后倒去上清液并加入等量的自来水或者矿泉水,重复此浸提过程1轮;合并浸提液过滤除杂,滤液经真空浓缩,得到单味中药提取物,分别干燥、粉碎、过80目筛后,用高速混合机充分混合,混合时间为20min,高速混合机转速为60r/min,经充分混合后制得本实施例配方粉末制品。
实施例3
一种改善男性性功能及抗疲劳的中药组合物,由以下重量份数的原料制备而成:
上述一种改善男性性功能及抗疲劳的中药组合物的制备方法,按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过80目筛后,充分混合。
(2)按1:10(m/v)加入矿泉水,在60℃温度下使用多模式超声波提取仪进行浸提。多模式超声波提取的具体参数为超声时间为30min;超声功率为150W/L;超声频率为20kHz/35kHz/60kHz。浸提结束后倒去上清液并加入等量的者矿泉水,重复此浸提过程1轮。合并浸提液过滤除杂,滤液经真空浓缩,冷冻干燥制得中药组合物。
实施例4
一种改善男性性功能及抗疲劳的中药组合物,由以下重量份数的中药材制备而成:
上述一种改善男性性功能及抗疲劳的中药组合物的制备方法,按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过100目筛后,
(2)每种原料按1:20(m/v)加入60%的乙醇-水溶液,在70℃温度下使用多模式超声波提取仪进行浸提。多模式超声波提取的具体参数为超声时间为30min;超声功率为150W/L;超声频率为35kHz/60kHz。浸提结束后倒去上清液并加入等量的60%的乙醇-水溶液,重复此浸提过程1轮;合并浸提液过滤除杂,滤液经真空浓缩,得到单味中药提取物,分别干燥、粉碎、过80目筛后,用高速混合机充分混合,混合时间为20min,高速混合机转速为60r/min,经充分混合后制得本实施例配方粉末制品。
实施例5
一种改善男性性功能及抗疲劳的保健食品,由以下重量份数的中药材制备而成:
上述中药属于卫计委公布的可用于保健食品的中药名单或者是卫计委公布的既是食品又是药品的中药名单。
上述一种改善男性性功能及抗疲劳的保健食品的制备方法,按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过80目筛后,充分混合。
(2)按1:15(m/v)加入自来水或者矿泉水,在60℃温度下使用多模式超声波提取仪进行浸提。多模式超声波提取的具体参数为超声时间为20min;超声功率为100W/L;超声频率为35kHz/40kHz。浸提结束后倒去上清液并加入等量的自来水或者矿泉水,重复此浸提过程1轮。合并浸提液过滤除杂,滤液经真空浓缩,冷冻干燥制得中药组合物。
实施例6
一种改善男性性功能及抗疲劳的保健食品,由以下重量份数的中药材制备而成:
上述一种改善男性性功能及抗疲劳的保健食品的制备方法,按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过100目筛后,
(2)每种原料按1:20(m/v)加入自来水或者矿泉水,在60℃温度下使用多模式超声波提取仪进行浸提。多模式超声波提取的具体参数为超声时间为40min;超声功率为180W/L;超声频率为28kHz/60kHz。浸提结束后倒去上清液并加入等量的自来水或者矿泉水,重复此浸提过程1轮;合并浸提液过滤除杂,滤液经真空浓缩,得到单味中药提取物,分别干燥、粉碎、过80目筛后,用高速混合机充分混合,混合时间为20min,高速混合机转速为60r/min,经充分混合后制得本实施例配方粉末制品。
实施例7
一种改善男性性功能及抗疲劳的保健食品,优选由以下重量份数的原料制备而成:
上述一种改善男性性功能及抗疲劳的保健食品的制备方法,按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过80目筛后,充分混合。
(2)按1:15(m/v)加入矿泉水,在60℃温度下使用多模式超声波提取仪进行浸提。多模式超声波提取的具体参数为超声时间为40min;超声功率为160W/L;超声频率为28kHz/60kHz。浸提结束后倒去上清液并加入等量的自来水或者矿泉水,重复此浸提过程1轮。合并浸提液过滤除杂,滤液经真空浓缩,冷冻干燥制得中药组合物。
对比例:常规提取步骤:将上述不同实施例中的原料按质量份数分别粉碎、过80目筛后,充分混合。按1:10(m/v)加入自来水,在60℃温度下和100℃温度下进行浸提。浸提结束后倒去上清液并加入等量的自来水,重复此浸提过程1轮。合并浸提液过滤除杂,滤液经真空浓缩,冷冻干燥制得中药组合物。
本发明中药复方中有效成分总提取率的测定方法如下:
将提取后所得提取液的上清液倒入干燥称重过的滤纸及玻璃漏斗,过滤到锥形瓶中,再用少量的乙醇洗涤烧杯和滤纸两次,然后将残渣及滤纸与玻璃漏斗在50℃下干燥至恒重。按照下式进行总提取率的计算:
式中:m—样品质量(g);m1—滤纸和漏斗质量(g);m2—滤纸、漏斗和残渣质量(g)。
表1本发明超声提取方法与常规方法对比
本发明具体实施方式中所用功能活性评价方法如下:
(1)改善性功能测定试验,具体操作步骤参考鲍雷等的方法(吉林人参低聚肽对雄性小鼠性功能影响的实验研究,鲍雷等,中国预防医学杂志2015年10月第16卷第10期)。
(2)评价试验所用动物为健康雄性ICR小鼠,5月年龄,体重18~22g,由江苏大学动物饲养中心提供,动物均在江苏大学实验动物中心屏障***内饲养,饲养环境昼夜各半,自由饮水、饮水,进食温度维持24±2℃,相对湿度50%~60%,室内照明控制在12h/12h光暗周期节律。
使用本发明各个实施例的配方进行功能活性评价试验结果表明,使用本发明各个实施例配方灌胃干预后,小鼠交配潜伏期缩短,20min内交配次数明显增加,由此可见,本发明配方是一种良好的增强性功能作用,可在一定程度上提高小鼠的***和性活动能力。同时小鼠***数量均有增加,与对照组相比,各个实施例处理组的***畸变率均减少,***活率均增加。说明本发明配方可有效抑制***畸变、提高***活率,且能不同程度的促进小鼠***数目(表2)。
使用本发明各个实施例的配方进行功能活性评价试验结果表明,使用本发明各个实施例配方灌胃干预后,可显著增加雄性小鼠附性器官重量,提高雄性小鼠血清的一氧化氮(NO)和睾酮浓度,NO浓度提高,可加强******能力,睾酮浓度增加可促进一氧化氮合酶(NOS)产生,抑制5型磷酸二酯酶(PDE5)产生,因此,本发明配方具有显著的改善性功能作用(表3)。
表2本发明实施例对小鼠交配潜伏期、交配次数及***质量的影响
表3本发明实施例对小鼠性器官脏器指数及血清中NO和睾酮含量的影响
Claims (10)
2.根据权利要求1所述的一种改善男性性功能及抗疲劳的中药组合物,其特征在于上述中药材中仙灵脾(10~20份)也可以用锁阳(10~20份)代替;
上述中药材中仙灵脾(10~20份)或者用紫河车(10~20份)代替,鹿角片(10~20份)用龟甲片(10~20份)代替;
其中所述的杜仲为炒杜仲为生杜仲用盐水淋喷拌匀,待吸尽,再用文火炒至黄褐色入药;
其中所述的黄芪为蜜炙黄芪,也就是黄芪片用蜂蜜拌匀,炒至不粘手时取出摊晾,而后入药的;
其中所述的甘草为炙甘草。
4.根据权利要求3所述的一种改善男性性功能及抗疲劳的中药组合物,其特征在于上述中药材中仙灵脾(15份)也可以用锁阳(15份)代替;
上述中药材中仙灵脾(15份)或者用紫河车(15份)代替,鹿角片(15份)用龟甲片(15份)代替。
5.权利要求1-4所述的一种改善男性性功能及抗疲劳的中药组合物的制备方法,其特征在于按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过80~100目筛后,充分混合;
(2)按1:10~20(m/v)加入自来水或者矿泉水,在60~70℃温度下使用多模式超声波提取仪进行浸提;浸提结束后倒去上清液并加入等量的自来水或者矿泉水,重复此浸提过程1轮;合并浸提液过滤除杂,滤液经真空浓缩,冷冻干燥制得中药组合物。
6.根据权利要求5所述的一种改善男性性功能及抗疲劳的中药组合物的制备方法,其特征在于其中步骤(2)所述的提取溶剂除了自来水或者矿泉水以外,也可以使用体积分数为40-70%的乙醇-水溶液;
其中步骤(2)所述多模式超声波提取的具体参数为超声时间10min-40min,优选超声时间为30min;超声功率60W/L-180W/L,优选超声功率为150W;超声频率20kHz、28kHz、35kHz、40kHz、60kHz,或者其两两组合,或者其三三组合,优选超声频率35kHz/60kHz或者20kHz/35kHz/60kHz。
7.权利要求1-4所述的一种改善男性性功能及抗疲劳的中药组合物的制备方法,其特征在于或者按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过80~100目筛后,
(2)每种原料按1:10~20(m/v)加入自来水或者矿泉水,在60~70℃温度下使用多模式超声波提取仪进行浸提;浸提结束后倒去上清液并加入等量的自来水或者矿泉水,重复此浸提过程1轮;合并浸提液过滤除杂,滤液经真空浓缩,喷雾干燥或者冷冻干燥制得到单味中药提取物,然后按照上述原料的比例混合即可得到中药组合物;
其中步骤(2)所述的提取溶剂除了自来水或者矿泉水以外,也可以使用体积分数为40-70%的乙醇-水溶液;
其中步骤(2)所述多模式超声波提取的具体参数为超声时间10min-40min,优选超声时间为30min;超声功率60W/L-180W/L,优选超声功率为150W;超声频率20kHz、28kHz、35kHz、40kHz、60kHz,或者其两两组合,或者其三三组合,优选超声频率35kHz/60kHz或者20kHz/35kHz/60kHz。
10.根据权利要求8或9所述的一种改善男性性功能及抗疲劳的保健食品的制备方法,其特征在于按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过80~100目筛后,充分混合;
(2)按1:10~20(m/v)加入自来水或者矿泉水,在60~70℃温度下使用多模式超声波提取仪进行浸提;浸提结束后倒去上清液并加入等量的自来水或者矿泉水,重复此浸提过程1轮;合并浸提液过滤除杂,滤液经真空浓缩,喷雾干燥或者冷冻干燥制得中药组合物;
其中步骤(2)所述的提取溶剂除了自来水或者矿泉水以外,也可以使用体积分数为40-70%的乙醇-水溶液;
其中步骤(2)所述多模式超声波提取的具体参数为超声时间10min-40min,优选超声时间为30min;超声功率60W/L-180W/L,优选超声功率为150W;超声频率20kHz、28kHz、35kHz、40kHz、60kHz,或者其两两组合,或者其三三组合,优选超声频率35kHz/60kHz或者20kHz/35kHz/60kHz;
或者按照下述步骤进行:
(1)将上述原料按质量份数分别粉碎、过80~100目筛后,
(2)每种原料按1:10~20(m/v)加入自来水或者矿泉水,在60~70℃温度下使用多模式超声波提取仪进行浸提;浸提结束后倒去上清液并加入等量的自来水或者矿泉水,重复此浸提过程1轮;合并浸提液过滤除杂,滤液经真空浓缩,喷雾干燥或者冷冻干燥制得到单味中药提取物,然后按照上述原料的比例混合即可得到中药组合物;
其中步骤(2)所述的提取溶剂除了自来水或者矿泉水以外,也可以使用体积分数为40-70%的乙醇-水溶液;
其中步骤(2)所述多模式超声波提取的具体参数为超声时间10min-40min,优选超声时间为30min;超声功率60W/L-180W/L,优选超声功率为150W;超声频率20kHz、28kHz、35kHz、40kHz、60kHz,或者其两两组合,或者其三三组合,优选超声频率35kHz/60kHz或者20kHz/35kHz/60kHz。
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