CN111214547A - A Chinese medicinal composition for treating lumbago, leg pain, and arthralgia and myalgia, and its preparation method - Google Patents
A Chinese medicinal composition for treating lumbago, leg pain, and arthralgia and myalgia, and its preparation method Download PDFInfo
- Publication number
- CN111214547A CN111214547A CN202010220115.7A CN202010220115A CN111214547A CN 111214547 A CN111214547 A CN 111214547A CN 202010220115 A CN202010220115 A CN 202010220115A CN 111214547 A CN111214547 A CN 111214547A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- traditional chinese
- mixture
- waist
- legs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 102
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 206010033425 Pain in extremity Diseases 0.000 title description 9
- 208000006820 Arthralgia Diseases 0.000 title description 5
- 208000008035 Back Pain Diseases 0.000 title description 3
- 208000008930 Low Back Pain Diseases 0.000 title description 3
- 208000000112 Myalgia Diseases 0.000 title description 3
- 239000003814 drug Substances 0.000 claims abstract description 72
- 230000036407 pain Effects 0.000 claims abstract description 39
- 208000002193 Pain Diseases 0.000 claims abstract description 38
- 210000001624 hip Anatomy 0.000 claims abstract description 31
- 239000002994 raw material Substances 0.000 claims abstract description 29
- 210000002414 leg Anatomy 0.000 claims abstract description 25
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 22
- 210000003205 muscle Anatomy 0.000 claims abstract description 19
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 11
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 11
- 241000722953 Akebia Species 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 52
- 239000000843 powder Substances 0.000 claims description 32
- 238000000498 ball milling Methods 0.000 claims description 30
- 238000001035 drying Methods 0.000 claims description 19
- 238000002156 mixing Methods 0.000 claims description 17
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 16
- 229930195725 Mannitol Natural products 0.000 claims description 16
- 239000000594 mannitol Substances 0.000 claims description 16
- 235000010355 mannitol Nutrition 0.000 claims description 16
- 229920000858 Cyclodextrin Polymers 0.000 claims description 11
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 11
- 239000001116 FEMA 4028 Substances 0.000 claims description 11
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 11
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 11
- 229960004853 betadex Drugs 0.000 claims description 11
- 239000000600 sorbitol Substances 0.000 claims description 11
- 235000010356 sorbitol Nutrition 0.000 claims description 11
- 230000008014 freezing Effects 0.000 claims description 9
- 238000007710 freezing Methods 0.000 claims description 9
- 238000002791 soaking Methods 0.000 claims description 9
- 238000005406 washing Methods 0.000 claims description 9
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 150000005846 sugar alcohols Chemical class 0.000 claims description 8
- 238000005303 weighing Methods 0.000 claims description 8
- 238000010257 thawing Methods 0.000 claims description 5
- 239000004386 Erythritol Substances 0.000 claims description 3
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 3
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 3
- 235000019414 erythritol Nutrition 0.000 claims description 3
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 3
- 229940009714 erythritol Drugs 0.000 claims description 3
- 244000061520 Angelica archangelica Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 241000213006 Angelica dahurica Species 0.000 abstract description 7
- 230000008901 benefit Effects 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 4
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 241000729196 Lycopus lucidus Species 0.000 abstract description 3
- 230000017531 blood circulation Effects 0.000 abstract description 2
- 230000004087 circulation Effects 0.000 abstract description 2
- 230000007721 medicinal effect Effects 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 32
- 238000012360 testing method Methods 0.000 description 21
- 239000011780 sodium chloride Substances 0.000 description 16
- 235000002639 sodium chloride Nutrition 0.000 description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 235000019441 ethanol Nutrition 0.000 description 11
- 244000152045 Themeda triandra Species 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 239000000679 carrageenan Substances 0.000 description 6
- 235000010418 carrageenan Nutrition 0.000 description 6
- 229940113118 carrageenan Drugs 0.000 description 6
- 229920001525 carrageenan Polymers 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 6
- 238000003745 diagnosis Methods 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000000832 lactitol Substances 0.000 description 4
- 235000010448 lactitol Nutrition 0.000 description 4
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 4
- 229960003451 lactitol Drugs 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 240000008027 Akebia quinata Species 0.000 description 3
- 235000007756 Akebia quinata Nutrition 0.000 description 3
- 208000003947 Knee Osteoarthritis Diseases 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 210000000629 knee joint Anatomy 0.000 description 3
- 201000008482 osteoarthritis Diseases 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 241000125175 Angelica Species 0.000 description 2
- 235000021511 Cinnamomum cassia Nutrition 0.000 description 2
- 206010023232 Joint swelling Diseases 0.000 description 2
- 206010024453 Ligament sprain Diseases 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- MGJZITXUQXWAKY-UHFFFAOYSA-N diphenyl-(2,4,6-trinitrophenyl)iminoazanium Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1N=[N+](C=1C=CC=CC=1)C1=CC=CC=C1 MGJZITXUQXWAKY-UHFFFAOYSA-N 0.000 description 2
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 2
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- GOZMBJCYMQQACI-UHFFFAOYSA-N 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride Chemical compound Cl.Cl.C=1OC2=CC(C)=C(C)C=C2C(=O)C=1CN(C)CCN(C)CC(C1=CC=CC=C11)=CN1C1=CC=CC(C(F)(F)F)=C1 GOZMBJCYMQQACI-UHFFFAOYSA-N 0.000 description 1
- 244000036770 Akebia trifoliata Species 0.000 description 1
- 235000012980 Akebia trifoliata Nutrition 0.000 description 1
- 244000130463 Alangium chinense Species 0.000 description 1
- 240000001810 Angelica gigas Species 0.000 description 1
- 235000018865 Angelica gigas Nutrition 0.000 description 1
- 241001254604 Angelica pubescens Species 0.000 description 1
- 241000208173 Apiaceae Species 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 208000000668 Chronic Pancreatitis Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 235000009926 Dioscorea panthaica Nutrition 0.000 description 1
- 241000374766 Dioscorea panthaica Species 0.000 description 1
- 241001312741 Gekko swinhonis Species 0.000 description 1
- 102000003777 Interleukin-1 beta Human genes 0.000 description 1
- 108090000193 Interleukin-1 beta Proteins 0.000 description 1
- 206010050296 Intervertebral disc protrusion Diseases 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 241001083838 Lardizabalaceae Species 0.000 description 1
- 241000218195 Lauraceae Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010050031 Muscle strain Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010030124 Oedema peripheral Diseases 0.000 description 1
- 206010033649 Pancreatitis chronic Diseases 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- 102000014128 RANK Ligand Human genes 0.000 description 1
- 108010025832 RANK Ligand Proteins 0.000 description 1
- 208000016247 Soft tissue disease Diseases 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 208000026062 Tissue disease Diseases 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000004883 caffeic acid Nutrition 0.000 description 1
- 229940074360 caffeic acid Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 1
- 230000009519 contusion Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- -1 erythriol Chemical compound 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000000323 shoulder joint Anatomy 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 208000037911 visceral disease Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for treating pains in waist, legs, bones and muscles and a preparation method thereof. The Chinese medicinal composition for treating pains in waist, legs and bones is prepared by using the Chinese angelica, the hiraute shiny bugleweed herb, the akebia stem and the cassia twig as raw materials, has scientific compatibility of medicines and simple formula, has the effects of promoting qi circulation, relieving depression, promoting blood circulation, relieving pain, dispelling wind, eliminating dampness, dispelling cold and relieving pain under the synergistic effect of the raw materials, has the advantages of good medicinal effect, quick response and the like, is low in price, is worthy of popularization, and has good social benefit and market prospect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating pains in waist, legs, bones and muscles and a preparation method thereof.
Background
Nowadays, with the rapid development of social economy, the living standard of people is increasingly improved, but many people still suffer from waist, leg, neck and shoulder joint pain which is usually caused by sequelae of sprain and contusion in operation, strain trauma or attack of wind-cold-dampness. Pain in the waist and legs, generalized low back pain, leg pain, soreness and numbness of legs and feet, etc., are clinically common symptoms, the incidence rate of the pain is second to that of cold, and the treatment of the pain is related to orthopedics, tuina department and acupuncture department. Possible causes of pain in the waist and legs are: bone, joint and soft tissue diseases, especially spine and paravertebral tissue diseases, such as acute lumbar sprain, lumbar intervertebral disc prolapse, chronic lumbar strain, and congenital malformation of lumbar vertebra; also may be pain caused by involvement of visceral diseases and acute and chronic inflammation and tumor of spine, such as kidney disease, chronic pancreatitis, diabetes, coronary heart disease and spine; it may also be caused by psychopsychological diseases, such as depression.
The present treatment and diagnosis of pain in the waist and lower extremities have some problems, above all, that are not regarded as important for the treatment and diagnosis of the disease, which is relative to the patients and doctors. Because the disease course is slow, people generally pay less attention to the disease, most people are not willing to go to a doctor when the work and life are affected without pain, so that the disease condition is delayed, the treatment effect is not good, and some people even can not be cured, so that the pain of the whole life is caused. There are also cases where some doctors do not see the doctor in the face of the patient, and what is diagnosed is not important, and finally, the doctor can treat the disease through surgery; then, the treatment method is not standard, and like a patient who is facing different doctors or different hospitals to see a doctor, some patients need to perform an operation, some patients do not need to take medicines, and some patients do not need to take medicines, so that the patient does not know how to deal with the condition of the patient; in addition, the treatment thought is extremely advanced, and some doctors can treat the illness state of the patient with the thought of the extremely advanced treatment thought, and doctors who specially do the operation think that the operation is not done, but do not do the operation, and when the doctors are not good at the operation, the operation risk is large, the effect is not good, the doctor possibly has sequelae, and the patient can be dissuaded from conservative treatment. These conditions are not optimal for the patient and can sometimes delay the patient's condition.
The waist and leg pain is gradually and more attracted by people under the conditions that the society and economy rapidly develop, the pace of work and life of people is continuously accelerated, and the disease gradually becomes a common disease, and some traditional Chinese medicine hospitals even appear in the department of waist and leg pain. Certainly, the waist and leg pain has become one of the main problems which plague modern life, so how to develop a traditional Chinese medicine composition which can effectively treat the waist and leg pain is a research which needs to be continuously explored.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a traditional Chinese medicine composition for treating pains in waist, legs, bones and muscles and a preparation method thereof.
A preparation method of a traditional Chinese medicine composition for treating pains in waist, legs, bones and muscles comprises the following steps:
weighing traditional Chinese medicine raw materials, and mixing to obtain a mixture;
placing the mixture in a color protection solution with the mass 2-5 times of that of the mixture, soaking for 1-6h, taking out, washing with water, draining, quickly freezing at-20-4 ℃ for 3-12h, thawing to obtain a thawed mixture, and drying the thawed mixture at 50-60 ℃ until the water content is 2.5-4 wt% to obtain a dried raw material;
and III, crushing the dried raw materials into 20-80 meshes to obtain traditional Chinese medicine powder, and adding the traditional Chinese medicine powder and β -cyclodextrin into ball milling equipment according to the mass ratio of 10 (0.01-0.03) for ball milling for 30-80min to obtain the traditional Chinese medicine powder.
Preferably, the preparation method of the traditional Chinese medicine composition for treating pain in waist, legs, bones and muscles comprises the following steps:
weighing traditional Chinese medicine raw materials, and mixing to obtain a mixture;
placing the mixture in a color protection solution with the mass 2-5 times of that of the mixture, soaking for 1-6h, taking out, washing with water, draining, quickly freezing at-20-4 ℃ for 3-12h, thawing to obtain a thawed mixture, placing the thawed mixture at 50-60 ℃ for drying until the water content is 55-65 wt%, and then performing vacuum microwave drying treatment until the water content is 2.5-4 wt% to obtain a dried raw material;
and III, crushing the dried raw materials into 20-80 meshes to obtain traditional Chinese medicine powder, and adding the traditional Chinese medicine powder and β -cyclodextrin into ball milling equipment according to the mass ratio of 10 (0.01-0.03) for ball milling for 30-80min to obtain the traditional Chinese medicine powder.
More preferably, the preparation method of the traditional Chinese medicine composition for treating pain in waist, legs, bones and muscles comprises the following steps:
weighing traditional Chinese medicine raw materials, and mixing to obtain a mixture;
placing the mixture in a color protection solution with the mass 2-5 times of that of the mixture, soaking for 1-6h, taking out, washing with water, draining, quickly freezing at-20-4 ℃ for 3-12h, thawing to obtain a thawed mixture, placing the thawed mixture at 50-60 ℃ for drying until the water content is 55-65 wt%, and then performing vacuum microwave drying treatment until the water content is 2.5-4 wt% to obtain a dried raw material;
and III, crushing the dried raw materials into 20-80 meshes to obtain traditional Chinese medicine coarse powder, carrying out superfine crushing treatment on the traditional Chinese medicine coarse powder for 3-15min to obtain traditional Chinese medicine powder, adding the traditional Chinese medicine powder and β -cyclodextrin into ball milling equipment according to the mass ratio of 10 (0.01-0.03), carrying out ball milling for 30-80min, and thus obtaining the traditional Chinese medicine powder.
Preferably, the microwave intensity of the vacuum microwave drying treatment is 4-8W/g, and the absolute pressure is 10-50 kPa.
Preferably, the superfine grinding frequency of the superfine grinding treatment is 20-50Hz, and the working pressure is 0.2-0.8 MPa.
The traditional Chinese medicine comprises the following raw materials: 20-40 parts of angelica, 20-40 parts of herba lycopi, 20-40 parts of akebia stem and 20-40 parts of cassia twig.
The preparation method of the color protection liquid comprises the following steps: mixing sugar alcohol, sodium chloride and water, wherein the mass ratio of the sugar alcohol to the sodium chloride to the water is (2-15): (0.2-1): (60-80), and stirring uniformly to obtain the product.
The sugar alcohol comprises one or more of mannitol, sorbitol and red grass alcohol.
Preferably, the sugar alcohol is prepared from mannitol, sorbitol and red grass alcohol according to a mass ratio of (1-5): (1-5): (1-5) mixing.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the following beneficial effects: the Chinese medicinal composition for treating pains in waist, legs and bones is prepared by using the Chinese angelica, the hiraute shiny bugleweed herb, the akebia stem and the cassia twig as raw materials, has scientific compatibility of medicines and simple formula, has the effects of promoting qi circulation, relieving depression, promoting blood circulation, relieving pain, dispelling wind, eliminating dampness, dispelling cold and relieving pain under the synergistic effect of the raw materials, has the advantages of good medicinal effect, quick response and the like, is low in price, is worthy of popularization, and has good social benefit and market prospect.
Detailed Description
The above summary of the present invention is described in further detail below with reference to specific embodiments, but it should not be understood that the scope of the above subject matter of the present invention is limited to the following examples.
Introduction of raw materials and equipment in the examples:
angelica, latin scientific name: angelica pubescens Maxim. f. biserrata shann et Yuan, a dried root of Angelica gigas nakai of Umbelliferae, purchased from Baichun pharmaceutical Co., Ltd, Bozhou.
Herba lycopi, Latin school name: lycopus lucidus Turcz. var. hirtus Regel, a dry aerial part of Gekko Swinhonis seedling of Labiatae, purchased from Hongtai Chinese herbal pieces of Ministry of Japan.
Akebia stem, Latin school name: akebia quinata (Houtt.) Decne, the woody stems of Akebia quinata or Akebia trifoliata, Akebia quinata, of the family Lardizabalaceae, purchased from Hongtai Chinese herbal pieces, llc of folk county.
Cassia twig, the academic name of latin: cinnamomum cassia Presl, a dried twig of Cinnamomum cassia of Lauraceae, purchased from Xiangguang medicinal materials, Inc. in Xiyao county.
Mannitol, food grade, available from Wuhan Wangrong scientific development Limited.
Lacquerol, food grade, purchased from Western Anda Dafengshou Biotech Limited.
Dioscorea panthaica alcohol, food grade, was purchased from Shandong, ternary Biotech, Inc.
β -Cyclodextrin food grade, available from Hebei Baiwei Biotech limited.
The comminution apparatus was a WKSJ-120 comminution machine available from sincere pharmaceutical equipment manufacturing ltd.
The ultramicro crushing equipment is a CP-100 type airflow crushing grader, and is purchased from Huashen aerodynamic technology application factories in Miyang city, Sichuan.
The vacuum microwave drying equipment is XWJD6SW-2 type microwave vacuum sterilization drying equipment and is purchased from electromechanical equipment factory of Nanjing Xiaomeima in Jiangsu province.
The ball mill equipment was a Pulverisette type 5 four-pot planetary high energy ball mill available from the German flying instruments.
Example 1
A preparation method of a traditional Chinese medicine composition for treating pains in waist, legs, bones and muscles comprises the following steps:
weighing 30 parts of Chinese angelica, 30 parts of herba lycopi, 30 parts of akebia stem and 30 parts of cassia twig according to the weight part ratio, and mixing to obtain a mixture;
II, placing the mixture into a color protection solution with the mass 3 times that of the mixture for soaking for 2 hours, taking out the mixture, washing the mixture with distilled water with the mass 1 time that of the mixture, draining the water, quickly freezing the mixture at the temperature of-6 ℃ for 4 hours, then unfreezing the mixture at the temperature of 20 ℃ for 8 hours to obtain an unfrozen mixture, then placing the unfrozen mixture at the temperature of 55 ℃ and drying the mixture until the water content is 3 wt%, thus obtaining a dried raw material;
and III, crushing the dried raw materials to 60 meshes to obtain traditional Chinese medicine powder, adding the traditional Chinese medicine powder and β -cyclodextrin into ball milling equipment according to the mass ratio of 10: 0.01 for ball milling, taking zirconia balls with the diameter of 10mm as ball milling media, setting the ball milling equipment with the ball-material ratio of 3:1 at 30 ℃ and 220r/min for ball milling for 50min to obtain the traditional Chinese medicine powder.
The preparation method of the color protection liquid comprises the following steps: mixing mannitol, sorbitol, red grass alcohol, sodium chloride and water, wherein the mass ratio of the mannitol, the sorbitol, the red grass alcohol, the sodium chloride and the water is 2: 2: 2: 0.5: 70, stirring for 1h at 40 ℃ and 500r/min to obtain the product.
Example 2
Essentially the same as example 1, except that: essentially the same as example 1, except that: the preparation method of the color protection liquid comprises the following steps: mixing mannitol, lactitol, sodium chloride and water, wherein the mass ratio of the mannitol to the lactitol to the sodium chloride to the water is 3: 3: 0.5: 70, stirring for 1h at 40 ℃ and 500r/min to obtain the product.
Example 3
Essentially the same as example 1, except that: essentially the same as example 1, except that: the preparation method of the color protection liquid comprises the following steps: mixing the lactitol, the red grass alcohol, the sodium chloride and water, wherein the mass ratio of the lactitol to the red grass alcohol to the sodium chloride to the water is 3: 3: 0.5: 70, stirring for 1h at 40 ℃ and 500r/min to obtain the product.
Example 4
Essentially the same as example 1, except that: essentially the same as example 1, except that: the preparation method of the color protection liquid comprises the following steps: mixing mannitol, erythriol, sodium chloride and water, wherein the mass ratio of the mannitol to the water to the red-serinol to the sodium chloride to the water is 3: 3: 0.5: 70, stirring for 1h at 40 ℃ and 500r/min to obtain the product.
Example 5
A preparation method of a traditional Chinese medicine composition for treating pains in waist, legs, bones and muscles comprises the following steps:
weighing 30 parts of Chinese angelica, 30 parts of herba lycopi, 30 parts of akebia stem and 30 parts of cassia twig according to the weight part ratio, and mixing to obtain a mixture;
placing the mixture in a color protection solution with the mass 3 times that of the mixture for soaking for 2 hours, taking out the mixture, washing the mixture with distilled water with the mass 1 time that of the mixture, draining the water, quickly freezing the mixture at-6 ℃ for 4 hours, then unfreezing the mixture at 20 ℃ for 8 hours to obtain an unfrozen mixture, obtaining the unfrozen mixture, then placing the unfrozen mixture at 55 ℃ for drying until the water content is 62 wt%, then performing vacuum microwave drying under the conditions of the microwave intensity of 6W/g and the absolute pressure of 30kPa until the water content is 3 wt%, and obtaining a dried raw material;
and III, crushing the dried raw materials to 60 meshes to obtain traditional Chinese medicine powder, adding the traditional Chinese medicine powder and β -cyclodextrin into ball milling equipment according to the mass ratio of 10: 0.01 for ball milling, taking zirconia balls with the diameter of 10mm as ball milling media, setting the ball milling equipment with the ball-material ratio of 3:1 at 30 ℃ and 220r/min for ball milling for 50min to obtain the traditional Chinese medicine powder.
The preparation method of the color protection liquid comprises the following steps: mixing mannitol, sorbitol, red grass alcohol, sodium chloride and water, wherein the mass ratio of the mannitol, the sorbitol, the red grass alcohol, the sodium chloride and the water is 2: 2: 2: 0.5: 70, stirring for 1h at 40 ℃ and 500r/min to obtain the product.
Example 6
A preparation method of a traditional Chinese medicine composition for treating pains in waist, legs, bones and muscles comprises the following steps:
weighing 30 parts of Chinese angelica, 30 parts of herba lycopi, 30 parts of akebia stem and 30 parts of cassia twig according to the weight part ratio, and mixing to obtain a mixture;
placing the mixture in a color protection solution with the mass 3 times that of the mixture for soaking for 2 hours, taking out the mixture, washing the mixture with distilled water with the mass 1 time that of the mixture, draining the water, quickly freezing the mixture at-6 ℃ for 4 hours, then unfreezing the mixture at 20 ℃ for 8 hours to obtain an unfrozen mixture, obtaining the unfrozen mixture, then placing the unfrozen mixture at 55 ℃ for drying until the water content is 62 wt%, then performing vacuum microwave drying under the conditions of the microwave intensity of 6W/g and the absolute pressure of 30kPa until the water content is 3 wt%, and obtaining a dried raw material;
and III, crushing the dried raw materials to 60 meshes to obtain traditional Chinese medicine coarse powder, then carrying out superfine crushing treatment on the traditional Chinese medicine coarse powder, wherein the superfine crushing frequency of the superfine crushing treatment is 30Hz, the working pressure is 0.6MPa, and the crushing time is 6min to obtain traditional Chinese medicine powder, adding the traditional Chinese medicine powder and β -cyclodextrin into ball milling equipment according to the mass ratio of 10: 0.01 for ball milling, taking zirconia balls with the diameter of 10mm as ball milling media, and placing the balls and the materials in the ball milling equipment with the ball-to-material ratio of 3:1 at 30 ℃ and 220r/min for ball milling for 50min, wherein the mass ratio of the traditional Chinese medicine coarse powder to β -cyclodextrin is 10: 0.01 to obtain the traditional Chinese medicine.
The preparation method of the color protection liquid comprises the following steps: mixing mannitol, sorbitol, red grass alcohol, sodium chloride and water, wherein the mass ratio of the mannitol, the sorbitol, the red grass alcohol, the sodium chloride and the water is 2: 2: 2:
0.5: 70, stirring for 1h at 40 ℃ and 500r/min to obtain the product.
Comparative example 1
A preparation method of a traditional Chinese medicine composition for treating pains in waist, legs, bones and muscles comprises the following steps:
weighing 30 parts of Chinese angelica, 30 parts of herba lycopi, 30 parts of akebia stem and 30 parts of cassia twig according to the weight part ratio, and mixing to obtain a mixture;
II, placing the mixture into a color protection solution with the mass 3 times that of the mixture for soaking for 2 hours, taking out the mixture, washing the mixture with distilled water with the mass 1 time that of the mixture, draining the water, quickly freezing the mixture at the temperature of-6 ℃ for 4 hours, then unfreezing the mixture at the temperature of 20 ℃ for 8 hours to obtain an unfrozen mixture, then placing the unfrozen mixture at the temperature of 55 ℃ and drying the mixture until the water content is 3 wt%, thus obtaining a dried raw material;
and III, crushing the dried raw materials to 60 meshes to obtain traditional Chinese medicine powder, adding the traditional Chinese medicine powder and β -cyclodextrin into ball milling equipment according to the mass ratio of 10: 0.01 for ball milling, taking zirconia balls with the diameter of 10mm as ball milling media, setting the ball milling equipment with the ball-material ratio of 3:1 at 30 ℃ and 220r/min for ball milling for 50min to obtain the traditional Chinese medicine powder.
The preparation method of the color protection liquid comprises the following steps: mixing sodium chloride and water, wherein the mass ratio of the sodium chloride to the water is 0.5: 70, stirring for 1h at 40 ℃ and 500r/min to obtain the product.
Test example 1
And (3) testing the oxidation resistance: referring to the test method in section 2.2.1 of the periodical literature of Turkey West, the content of ferulic acid and caffeic acid in different extracting solutions of Chinese angelica and the comparative research on antioxidation, the DPPH method is adopted to test the antioxidation performance of the traditional Chinese medicine composition for treating lumbocrural pain and arthralgia and myalgia. The specific test method comprises the following steps: firstly, 100g of the traditional Chinese medicine composition is added into 1L of water for decoction for 1 hour, then the water decoction is diluted to 10mg/mL by deionized water to obtain a sample solution, 50 mu L of the sample solution is taken to be placed in a test tube, 100 mu L of DPPH solution of 120 mu g/m L is added to be uniformly mixed, after standing in a dark place for 30min at room temperature, the absorbance value at 517nm is measured and is counted as Ai, simultaneously 100 mu L of absolute ethyl alcohol is measured for 50 mu L of the sample solution, after standing in a dark place for 30min at room temperature, the absorbance value at 517nm is measured and is counted as Aj, and 50 mu L of distilled water is added into 100 mu L of LDPPH solution and is stood, and the absorbance value at 517nm is measured and is. The DPPH radical clearance rate of the sample is calculated according to the following formula: the clearance is [1- (Ai-Aj)/Ac ] × 100%. The specific test results are shown in table 1.
Table 1: antioxidant performance test result table
Sample (I) | DPPH radical clearance% |
Example 1 | 76.2 |
Example 2 | 66.5 |
Example 3 | 67.8 |
Example 4 | 67.1 |
Example 5 | 80.5 |
Example 6 | 85.9 |
Comparative example 1 | 61.6 |
As can be seen from the test results, the sugar alcohol of example 1, which is a mixture of mannitol, sorbitol and erythritol, has an antioxidant effect superior to that of examples 2-4 (the sugar alcohol is composed of any two of mannitol, sorbitol and erythritol) and comparative example 1, in which no sugar alcohol is added.
Test example 2
Anti-inflammatory experiment, referring to the experiment method in section 2 of journal literature of Jiangyong, namely the influence of Miao medicament Alangium chinense water extract on serum IL-1 β and TNF- α levels and a synovial membrane OPG/RANKL/RANK system, the influence of the traditional Chinese medicine composition for treating pain in waist and legs and bones on carrageenan foot swelling of mice is observed, 70 Kunming white mice (with the qualification number of SCXK (Liao) 2003-enriched animals purchased from the center of the university of Yang pharmacy) are selected in the experiment, half of male and female mice, the weight (22 +/-2) g is randomly divided into 7 groups, blank groups and experiment groups of examples 1-6, 10 groups are selected in each group, wherein the blank groups are given with physiological saline, other groups are given with correspondingly prepared sample liquid respectively, each mouse is given with gastric lavage for 1 time every day, the dosage of each administration is 10mL, the continuous administration is carried out for 7 days, 30min after final administration, the mouse foot pad is injected with 1 wt% of carrageenan, the subcutaneous paste is prepared for 1 wt%, the test result of the test, the test result of the radius of the swelling of each mouse is compared with the test sample, the observation of the test result of the radius of the test is obtained by adding a 0.05, the test method, the method is carried out on the statistics on the radius of the swelling of the test, the test of the swelling of the test of the carrageenan, the test of the carrageenan, the carrageenan.
Table 2: anti-inflammatory test results table
According to the test results, the steps of crushing, drying and the like are optimized in the example 6, and the finally prepared traditional Chinese medicine composition has a very obvious inhibiting effect on mouse carrageenan foot edema, and the anti-inflammatory strength of the traditional Chinese medicine composition is superior to that of the example 1.
Test example 3
The treatment effect is as follows: the effect test of treating knee osteoarthritis is carried out on the traditional Chinese medicine composition for treating pain in waist, legs, bones and muscles. According to the diagnosis standard of knee osteoarthritis of 2002 arthritis diagnosis and treatment guidelines of the Chinese medical society, 180 knee osteoarthritis patients are selected, the disease course is 2 years to 3 years, the age is 50-65 years, the average age is 55 years, the patients are randomly divided into 6 groups, 30 cases of each group are respectively used with the traditional Chinese medicine composition for treating waist and leg pain, the using method is that 200g of the traditional Chinese medicine composition for treating waist and leg pain is taken every day and added into 1000g of water for decoction for 1h, the water decoction is taken orally twice a day, the amount of the water decoction taken orally is 200g each time, the treatment effect of the traditional Chinese medicine composition is observed after 6 weeks of treatment, and the treatment evaluation standard is judged according to the traditional Chinese medicine syndrome diagnosis curative effect standard established by the national traditional Chinese medicine administration: and (3) curing: the knee joint swelling and pain disappear, the flexion and extension range returns to normal, and the walking is free; the effect is shown: the knee joint swelling basically disappears or obviously declines, the pain is obviously relieved, and the flexion and extension range is basically normal; improvement: the swelling and pain of the knee joint are relieved and relieved in different degrees, and the flexion and extension range is also improved; and (4) invalidation: there was no relief of knee swelling and pain. The specific treatment results are shown in table 3.
Table 3: therapeutic effect data sheet
The foregoing is considered as illustrative and not restrictive in character, and that all equivalent and simple variations on the principles taught herein are included within the scope of the present invention; various modifications, additions and substitutions for the specific embodiments described may be made by those skilled in the art without departing from the scope of the invention as defined in the accompanying claims.
Claims (8)
1. A preparation method of a traditional Chinese medicine composition for treating pains in waist, legs, bones and muscles is characterized by comprising the following steps:
weighing traditional Chinese medicine raw materials, and mixing to obtain a mixture;
placing the mixture in a color protection solution with the mass 2-5 times of that of the mixture, soaking for 1-6h, taking out, washing with water, draining, quickly freezing at-20-4 ℃ for 3-12h, thawing to obtain a thawed mixture, and drying the thawed mixture at 50-60 ℃ until the water content is 2.5-4 wt% to obtain a dried raw material;
and III, crushing the dried raw materials into 20-80 meshes to obtain traditional Chinese medicine powder, and adding the traditional Chinese medicine powder and β -cyclodextrin into ball milling equipment according to the mass ratio of 10 (0.01-0.03) for ball milling for 30-80min to obtain the traditional Chinese medicine powder.
2. The preparation method of the traditional Chinese medicine composition for treating pains in waist, legs, bones and muscles as claimed in claim 1, wherein the traditional Chinese medicine raw materials are as follows: 20-40 parts of angelica, 20-40 parts of herba lycopi, 20-40 parts of akebia stem and 20-40 parts of cassia twig.
3. The method of claim 1, wherein the sugar alcohol comprises one or more of mannitol, sorbitol, and erythritol.
4. The preparation method of the traditional Chinese medicine composition for treating pains in waist, legs, bones and muscles as claimed in claim 1, wherein the step II is as follows: placing the mixture in a color protection solution with the mass 2-5 times of that of the mixture, soaking for 1-6h, taking out, washing with water, draining, quickly freezing at-20-4 ℃ for 3-12h, thawing to obtain a thawed mixture, placing the thawed mixture at 50-60 ℃ for drying until the water content is 55-65 wt%, and then performing vacuum microwave drying treatment until the water content is 2.5-4 wt% to obtain a dried raw material.
5. The method for preparing a Chinese medicinal composition for treating pains in waist, legs, bones and muscles as claimed in claim 4, wherein the microwave intensity of the vacuum microwave drying treatment is 4-8W/g, and the absolute pressure is 10-50 kPa.
6. The preparation method of the traditional Chinese medicine composition for treating pains in waist, legs, bones and muscles according to claim 1, wherein the step III is to crush the dried raw materials into 20-80 meshes to obtain traditional Chinese medicine coarse powder, then to carry out superfine crushing treatment on the traditional Chinese medicine coarse powder for 3-15min to obtain traditional Chinese medicine powder, and to add the traditional Chinese medicine powder and β -cyclodextrin into a ball milling device according to the mass ratio of 10 (0.01-0.03) to carry out ball milling for 30-80min to obtain the traditional Chinese medicine composition.
7. The method for preparing a Chinese medicinal composition for treating pains in waist, legs, bones and muscles as claimed in claim 6, wherein the micronization frequency is 20-50Hz and the working pressure is 0.2-0.8 MPa.
8. A Chinese medicinal composition for treating pains in waist, legs, bones and muscles, which is prepared by the preparation method of the Chinese medicinal composition for treating pains in waist, legs, bones and muscles according to any one of claims 1 to 7.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010220115.7A CN111214547A (en) | 2020-03-25 | 2020-03-25 | A Chinese medicinal composition for treating lumbago, leg pain, and arthralgia and myalgia, and its preparation method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010220115.7A CN111214547A (en) | 2020-03-25 | 2020-03-25 | A Chinese medicinal composition for treating lumbago, leg pain, and arthralgia and myalgia, and its preparation method |
Publications (1)
Publication Number | Publication Date |
---|---|
CN111214547A true CN111214547A (en) | 2020-06-02 |
Family
ID=70826460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010220115.7A Pending CN111214547A (en) | 2020-03-25 | 2020-03-25 | A Chinese medicinal composition for treating lumbago, leg pain, and arthralgia and myalgia, and its preparation method |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111214547A (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103734292A (en) * | 2014-01-15 | 2014-04-23 | 中国热带农业科学院农产品加工研究所 | Method for keeping form of galangals and protecting color of galangals by forced air drying through combination of freezing and microwaving |
CN107736545A (en) * | 2017-10-27 | 2018-02-27 | 云南师宗凤凰谷食品有限责任公司 | A kind of vacuum freeze-drying method of food and medicine rhizome |
CN108434201A (en) * | 2018-05-07 | 2018-08-24 | 鄱阳县九九医院有限公司 | Treat the Chinese medicine composition and preparation method thereof of lumbocrural pain |
CN109288938A (en) * | 2018-11-13 | 2019-02-01 | 南宁学院 | A kind of Chinese medicine composition and preparation method thereof for treating waist-leg, arthralgia and myalgia |
-
2020
- 2020-03-25 CN CN202010220115.7A patent/CN111214547A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103734292A (en) * | 2014-01-15 | 2014-04-23 | 中国热带农业科学院农产品加工研究所 | Method for keeping form of galangals and protecting color of galangals by forced air drying through combination of freezing and microwaving |
CN107736545A (en) * | 2017-10-27 | 2018-02-27 | 云南师宗凤凰谷食品有限责任公司 | A kind of vacuum freeze-drying method of food and medicine rhizome |
CN108434201A (en) * | 2018-05-07 | 2018-08-24 | 鄱阳县九九医院有限公司 | Treat the Chinese medicine composition and preparation method thereof of lumbocrural pain |
CN109288938A (en) * | 2018-11-13 | 2019-02-01 | 南宁学院 | A kind of Chinese medicine composition and preparation method thereof for treating waist-leg, arthralgia and myalgia |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100423761C (en) | Chinese medicinal preparation for treating fracture, traumatic injury | |
CN103520432B (en) | Traditional Chinese medicine for treating qi-stagnation and blood stasis lumbar disc herniation and preparation method thereof | |
CN101293065B (en) | Biological proprietary Chinese medicine for preventing and treating diabetes | |
CN105125792A (en) | Traditional Chinese medicinal decoction for treating female mastitis and preparation method of decoction | |
CN111214547A (en) | A Chinese medicinal composition for treating lumbago, leg pain, and arthralgia and myalgia, and its preparation method | |
CN103285203A (en) | Traditional Chinese medicine composition for preventing and treating bone fracture and preparation method thereof | |
CN107050138A (en) | Pharmaceutical composition and its preparation and paste preparation method for treating osteoproliferation | |
CN109925367A (en) | A kind of prevention and treatment hemorrhoid fit perfectly | |
CN104306948A (en) | Medicament composition for treating gouty arthritis | |
CN104225259A (en) | Traditional Chinese medicine for treating stagnant heat type angiitis and preparation method thereof | |
CN104162114A (en) | Traditional Chinese medicine composition for treating wind-cold obstruction type cervical spondylotic radiculopathy | |
CN108553585A (en) | It is a kind of to treat lipoma and fibromatous Chinese medicine preparation and preparation method thereof | |
WO2022104712A1 (en) | Compound composition having effect of promoting bone health, preparation method therefor and application thereof | |
CN102551069B (en) | Round-grained nonglutinous rice for preventing nephritis and preparation method thereof | |
CN107913399A (en) | A kind of Chinese and Western for treating osteoporosis combines pharmaceutical composition and preparation method | |
CN101954043A (en) | Medicament for treating hyperosteogeny and preparation method thereof | |
CN106924673A (en) | A kind of Chinese medicine composition for treating osteoproliferation and its medicament preparation method | |
CN105232642A (en) | Traditional Chinese medicine combination capable of promoting fracture healing | |
CN105168945A (en) | External ointment for promoting fracture healing and preparation method of external ointment | |
CN103690902A (en) | Traditional Chinese medicinal preparation for preventing radiation side reactions of nasopharynx cancer chemoradiotherapy | |
CN104435404A (en) | Traditional Chinese medicine preparation for treating vertebra osteomyelitis and preparation method of traditional Chinese medicine preparation | |
CN103735676A (en) | Traditional Chinese medicine compound preparation for treating traumatic injury, and preparation method and application thereof | |
CN105213718A (en) | For the Chinese medicine composition of malignant arrhythmia | |
CN104721335A (en) | TCM (traditional Chinese medicine) composition for treating follicular cyst | |
CN104436069A (en) | Traditional Chinese medicine for treating intercostal neuralgia and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200602 |
|
RJ01 | Rejection of invention patent application after publication |