CN105213718A

CN105213718A - For the Chinese medicine composition of malignant arrhythmia

Info

Publication number: CN105213718A
Application number: CN201510686107.0A
Authority: CN
Inventors: 岳宏丽; 刘霞
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-10-15
Filing date: 2015-10-15
Publication date: 2016-01-06

Abstract

The present invention relates to a kind of pharmaceutical formulation field, specifically a kind of Chinese medicine composition for malignant arrhythmia, it is characterized in that being made up of the crude drug of following weight portion: Radix Cochleariae officinalis grass 5 ~ 9, Pueraria lobota Bud 4 ~ 7, Folium Et Cacumen Murrayae 4 ~ 8, Herba Pyrolae 4 ~ 7, hyoscyami 4 ~ 8, Herba Clinopodii 5 ~ 8, Herba Euphorbiae Humifusae 6 ~ 9, Herba cypripedii japonici 6 ~ 9, Herba Typhae 7 ~ 9, Flos Magnoliae Officinalis 6 ~ 9, Caulis Spatholobi 2 ~ 5, Rhizoma Dioscoreae Septemlobae 6 ~ 9, Fructus Citri 2 ~ 5, Cordyceps militaris (L.) Link. 4 ~ 6, Herb Gynostemmae Pentaphylli 2 ~ 4, Herba Apocyni veneti 4 ~ 6, Herba Saxifragae 2 ~ 4, Fructus Phyllanthi 7 ~ 9, by medicinal for above-mentioned raw materials water soaking, to remove slag after decocting to obtain filtrate.The present invention treats the advantages such as coronary heart disease malignant arrhythmia is evident in efficacy, with low cost, without any side effects.

Description

For the Chinese medicine composition of malignant arrhythmia

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine composition for malignant arrhythmia.

Background technology

As everyone knows, malignant arrhythmia mainly refers to quiver in the room speed of hemodynamic instability and room, and being the major reason of dying suddenly, is also the lethal one of the main reasons of coronary heart disease and arrhythmia patient.Most of malignant arrhythmia is with organic heart disease (as coronary heart disease, cardiomyopathy, heart failure etc.).Multiple clinical trial confirms that amiodarone can control the outbreak of malignant arrhythmia effectively in recent years, improves the effect of electrical conversion, reduces arrhythmia and general mortality rate.QT dispersion (QTd) significant prolongation in coronary heart disease malignant arrhythmia patient, and closely related with malignant arrhythmia.Amiodarone is the common drug for the treatment of Identifying Patients of Ventricular Arrhythmias With Coronary Artery Disease, and in the short time, the heavy dose of amiodarone of quiet note often proves effective, but long-term treatment, then there is larger side effect

Summary of the invention

Object of the present invention is exactly to overcome above-mentioned existing technical deficiency, provides a kind of evident in efficacy, with low cost, Chinese medicine composition for malignant arrhythmia of having no side effect.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine composition for malignant arrhythmia, it is characterized in that being made up of the crude drug of following weight portion: Radix Cochleariae officinalis grass 5 ~ 9, Pueraria lobota Bud 4 ~ 7, Folium Et Cacumen Murrayae 4 ~ 8, Herba Pyrolae 4 ~ 7, hyoscyami 4 ~ 8, Herba Clinopodii 5 ~ 8, Herba Euphorbiae Humifusae 6 ~ 9, Herba cypripedii japonici 6 ~ 9, Herba Typhae 7 ~ 9, Flos Magnoliae Officinalis 6 ~ 9, Caulis Spatholobi 2 ~ 5, Rhizoma Dioscoreae Septemlobae 6 ~ 9, Fructus Citri 2 ~ 5, Cordyceps militaris (L.) Link. 4 ~ 6, Herb Gynostemmae Pentaphylli 2 ~ 4, Herba Apocyni veneti 4 ~ 6, Herba Saxifragae 2 ~ 4, Fructus Phyllanthi 7 ~ 9, by medicinal for above-mentioned raw materials water soaking, to remove slag after decocting to obtain filtrate.

The invention has the beneficial effects as follows, the advantages such as treatment coronary heart disease malignant arrhythmia is evident in efficacy, with low cost, without any side effects.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Radix Cochleariae officinalis grass, Pueraria lobota Bud, Folium Et Cacumen Murrayae, Herba Pyrolae, hyoscyami, Herba Clinopodii, Herba Euphorbiae Humifusae, Herba cypripedii japonici, Herba Typhae, Flos Magnoliae Officinalis, Caulis Spatholobi, Rhizoma Dioscoreae Septemlobae, Fructus Citri, Cordyceps militaris (L.) Link., Herb Gynostemmae Pentaphylli, Herba Apocyni veneti, Herba Saxifragae, Fructus Phyllanthi is adopted to be that raw material is prepared from.The every pair of its component (weight portion) is Radix Cochleariae officinalis grass 7, Pueraria lobota Bud 6, Folium Et Cacumen Murrayae 6, Herba Pyrolae 5, hyoscyami 6, Herba Clinopodii 6, Herba Euphorbiae Humifusae 7, Herba cypripedii japonici 7, Herba Typhae 8, Flos Magnoliae Officinalis 7, Caulis Spatholobi 4, Rhizoma Dioscoreae Septemlobae 8, Fructus Citri 3, Cordyceps militaris (L.) Link. 5, Herb Gynostemmae Pentaphylli 3, Herba Apocyni veneti 5, Herba Saxifragae 3, Fructus Phyllanthi 8.Get above-mentioned 18 taste raw materials, gross weight is 176 grams, add water 800 ~ 900 milliliters and at room temperature soak 5 ~ 6 hours, slow fire decocted to 60 ~ 80 minutes, filtrate about 150 milliliters of removing slag to obtain, and medicinal residues add water 200 ~ 300ml again, decoct 20 ~ 30 minutes, to remove slag to obtain filtrate 50 ~ 70 milliliters, altogether the medicine juice of about 200 ~ 220 milliliters, i.e. obtained decoction of the present invention.Load in sterile glass vials, seal bottle cap is for subsequent use, and every day 1 dose point 2 times is oral, sooner or later respectively once, and each (medicine) being taken before meal 100 ~ 110 milliliters.

Radix Cochleariae officinalis grass warming the meridian and promoting blood circulation of the present invention, promoting blood circulation and stopping pain.Main coronary heart disease, angina pectoris, thromboangiitis obliterans; Pueraria lobota Bud tonifying five ZANG-organs, reuniting the fractured tendons and bones, QI invigorating, quenches the thirst; Folium Et Cacumen Murrayae promoting flow of QI and blood, eliminating stasis to stop pain, removing toxic substances and promoting subsidence of swelling; Herba Pyrolae energy tonify deficiency, kidney tonifying, expelling wind and removing dampness, promoting blood flow to regulate menstruation, the kidney invigorating bone strengthening; Hyoscyami has the effect of determining epilepsy, pain relieving, be usually used in demented, the migratory arthralgia for the treatment of faint pain, breath with cough; Herba Clinopodii is used for metrorrhagia, hematuria, epistaxis, gingival hemorrhage, wound hemorrhage; Herba Euphorbiae Humifusae heat-clearing and toxic substances removing, dampness removing jaundice eliminating, promoting blood circulation and hemostasis; Herba cypripedii japonici has promoting blood flow to regulate menstruation, analgesia of dispeling the wind, the effects such as preventing the attack (or recurrence) of malaria; Herba Typhae hemostasis, pain relieving, granulation promoting; Flos Magnoliae Officinalis is regulated the flow of vital energy, removing dampness.For the vexed distension of breast gastral cavity painful abdominal mass, poor appetite; Caulis Spatholobi has relaxing muscles and tendons to promote blood circulation, and effect of nourishing blood for regulating menstruation, cures mainly rheumatic arthralgia, numb hand and foot, quadriplegia; Rhizoma Dioscoreae Septemlobae dampness removing goes turbid, wind expelling stagnation removing; Fructus Citri suppressing the hyperactive liver Shu Yu, reason lung qi, stimulate the menstrual flow diuretic, controls waist foot gas; Cordyceps militaris (L.) Link. can tonifying the lung cloudy, again can kidney-replenishing, cure mainly and suffer from a deficiency of the kidney, impotence and seminal emission, soreness of waist and knee joint; Herb Gynostemmae Pentaphylli replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing; Herba Apocyni veneti is calm, anticonvulsant action, and has stronger diuresis, reduction blood fat, immunity moderation effect; Herba Saxifragae damp eliminating is subsided a swelling, cooling blood for hemostasis, heat-clearing and toxic substances removing; Fructus Phyllanthi helps digestion, diuretic, reduces phlegm, parasite killing.For vascular hypertension, stomachache, has loose bowels, scrofula.

The each raw material of the present invention also can the embodiment that mixes of ratio (weight portion) listed by according to the form below realize.Its processing technique is identical with embodiment 1.

The clinical trial carried out below in conjunction with my institute is done further the present invention, is described in detail:

1. data and method

1.1 physical data

All patients all meets the diagnostic criteria that WHO recommends, and is divided into two groups at random.Treatment group 50 example, male 27 example, women 23 example; Sick 31 examples of accompanied with hypertension, type 2 diabetes mellitus 17 example, 35 Cases of Hyperlipidemia.Matched group 50 example, male 24 example, women 26 example; Sick 29 examples of accompanied with hypertension, 2 type glycosuria 18 examples, hyperlipemia 32 example.Two groups of physical data no significant differences (P > 0.05).

1.2 Therapeutic Method

All take a routine treatment after patient people institute, intravenous amiodarone loading 3 ~ 5mg/kg, quiet note in 10min after dilution, vein maintenance dose is starting dose 1.0 ~ 1.5mg/min, according to state of an illness adjustment dosage; Auxiliary etiological treatment (polarized solution, aspirin, Statins, nitrate esters, ACEI and B receptor blocking agent), treatment group gives medicine of the present invention in the 1st day after amiodarone on treating, every day 1 dose point 2 times is oral, sooner or later each once, each (medicine) being taken before meal 100 ~ 110 milliliters.Matched group is treated routinely.Be 30 days the course for the treatment of.

1.3 observational technique

Often organize during medication and detect 12 lead electrocardiogram every day, except T, V wavelength-division circle is unclear or T ripple low flat lead outside, each measurement 3 Q-T that lead, interval, gets its meansigma methods, deducts the shortest QT interval be QTdo from the QT interval that difference is led the longest

1.4 statistical procedures

Application SPSS10.0 statistical software, measurement data represents with (X ± s), adopts X2 inspection and t inspection.

2. result

QT dispersion level close (P > 0.05) during two groups of patient admits

2.1 liang of group treatments period QT dispersion levels compare in table 1.

Table 1 treatments period QT dispersion level compares

After treatment the 1st day, two groups of QT dispersion levels all raised obviously, but two groups are compared difference there are no significant (P > 0.05); Later the 7th, 15,30 day two groups compare difference and all have significant difference (P < 0.01).

Treatment group on 7th compared with the 1st day, QT dispersion starts obviously to decline front and back significant difference (P < 0.05), until the 15th, the 30th compares, QT dispersion but still significantly lower than (P < 0.01) on the 1st.

Matched group on 7th compared with the 1st day, QT dispersion starts to decline, front and back difference has statistical significance (P < 0.05), but QT dispersion level level had declined not obvious (P > 0.05) compared with the 15th, the 30th on 1;

3. conclusion

Confirmed by above clinical trial, medicine of the present invention obviously can reduce the QT dispersion level of coronary heart disease malignant arrhythmia patient, determined curative effect, and therefore, medicine of the present invention effectively can treat coronary heart disease malignant arrhythmia.

Claims

1. the Chinese medicine composition for malignant arrhythmia, it is characterized in that: be made up of the crude drug of following weight portion: Radix Cochleariae officinalis grass 5 ~ 9, Pueraria lobota Bud 4 ~ 7, Folium Et Cacumen Murrayae 4 ~ 8, Herba Pyrolae 4 ~ 7, hyoscyami 4 ~ 8, Herba Clinopodii 5 ~ 8, Herba Euphorbiae Humifusae 6 ~ 9, Herba cypripedii japonici 6 ~ 9, Herba Typhae 7 ~ 9, Flos Magnoliae Officinalis 6 ~ 9, Caulis Spatholobi 2 ~ 5, Rhizoma Dioscoreae Septemlobae 6 ~ 9, Fructus Citri 2 ~ 5, Cordyceps militaris (L.) Link. 4 ~ 6, Herb Gynostemmae Pentaphylli 2 ~ 4, Herba Apocyni veneti 4 ~ 6, Herba Saxifragae 2 ~ 4, Fructus Phyllanthi 7 ~ 9, by medicinal for above-mentioned raw materials water soaking, filtrate of removing slag after decocting to obtain.