CN111214387A

CN111214387A - A composition for preventing or improving oral diseases

Info

Publication number: CN111214387A
Application number: CN202010153094.1A
Authority: CN
Inventors: 黎菊梅
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-03-06
Filing date: 2020-03-06
Publication date: 2020-06-02

Abstract

The invention discloses a composition for preventing or improving oral diseases, which comprises a matrix, micron-sized precipitated silica and paeonol as active ingredients, wherein the content of the micron-sized precipitated silica is 0.1-30%, and the content of the paeonol is 0.1-5%.

Description

A composition for preventing or improving oral diseases

Technical Field

The invention relates to the technical field of oral care, in particular to a composition for preventing or improving oral diseases.

Background

According to the research, dentin sensitivity is caused by the loss of tooth enamel due to tooth decay or mechanical abrasion, the tubules originally covered by the tooth enamel are exposed, and the pulp nerves in the tubules are stimulated by external cold, hot, sour and sweet and the like to generate intolerable ache.

The active substance adopted by the oral cavity product which is claimed to have the tooth desensitizing/anti-allergy effects at present is basically 5 percent of potassium salt or 10 percent of strontium salt as a desensitizer, and the technology is used for full-series desensitizer toothpastes such as famous brand comfort toothpaste, clomazone toothpaste and the like. Although effective, the technical disadvantages of high concentrations of potassium/strontium salts are equally significant, which have a significant impact on the mouth feel, can cause the toothpaste to become very bitter (potassium and strontium salts are bitter in taste), and the salts can defoam, can become less foamy during tooth brushing, can cause a user to feel that tooth brushing is not clean after use, and in addition, the desensitizing effect of the salts is relatively short in duration, which is also not conducive to product promotion.

Disclosure of Invention

1. Technical problem to be solved

The size of the tubules is 3-5 microns and thus, it can be filled and blocked with micron-sized precipitated silica (D50 medium size of 0.1-5 microns) smaller than it. In addition, paeonol is a substance with a certain anesthetic effect on nerves, so that the micron-sized precipitated silica and the paeonol are combined for use, so that the dental nerves exposed in the dental tubules can be simultaneously blocked and anesthetized, and the synergistic effect of desensitizing the teeth is achieved.

Meanwhile, aiming at the problems and the defects in the prior art, the invention provides the oral composition added with the micron precipitated silica and paeonol composition, which has lasting and effective anti-allergy effect on teeth, has no influence on the taste of the product, is not bitter and astringent, has rich foam and is very suitable for popularization of the product.

2. Technical scheme

In order to solve the above problems, the present invention adopts the following technical solutions.

A composition for preventing or improving oral diseases comprises a base and, as active ingredients, precipitated silica in micron size and paeonol.

The oral disease is oral dentin hypersensitiveness.

Preferably, in the composition, the content of the micron-sized precipitated silica is 0.1% -30%, and the content of the paeonol is 0.1% -5%.

Further, the matrix specifically comprises 2% -4% of PEG 400, 45% -55% of sorbitol, 0.8% -1% of thickening agent, 0.15% -0.22% of saccharin sodium, 0.2% -0.25% of sodium fluoride, 0.4% -0.55% of titanium dioxide, 13% -16% of friction type silicon dioxide, 0.18% -0.22% of K12, 0.8% -1.3% of essence, 0.09% -0.12% of methyl hydroxybenzoate, 0.07% -0.09% of propyl hydroxybenzoate, and the balance of water.

Preferably, the composition specifically comprises 3% of PEG 400, 50% of sorbitol, 0.9% of thickener, 0.2% of saccharin sodium, 0.23% of sodium fluoride, 0.5% of titanium dioxide, 15% of friction type silicon dioxide, 2% of K12, 1% of essence, 0.1% of methylparaben, 0.08% of propylparaben, 6% of micron precipitated silicon dioxide, 0.2% of paeonol, and the balance of water.

Further, another matrix specifically comprises 0.08-0.12% of saccharin sodium, 0.18-0.21% of essence, 0.09-0.11% of methylparaben, 0.07-0.09% of propylparaben and the balance of calcium hydrophosphate.

Preferably, the composition specifically comprises 0.1% of saccharin sodium, 0.2% of essence, 0.1% of methylparaben, 0.08% of propylparaben, 6% of micron precipitated silica, 0.2% of paeonol, and the balance of calcium hydrogen phosphate.

Compared with the prior art, the invention has the following beneficial effects:

(1) has lasting anti-allergy effect on teeth;

(2) the invention has no influence on the taste of the product and has no bitter taste;

(3) the foam is rich, and the use experience is good.

Drawings

FIG. 1 is an electron micrograph of a tooth surface after brushing with a conventional toothpaste (the enamel of the tooth has been abraded prior to brushing);

FIG. 2 is an electron micrograph of a tooth surface after brushing with a dentifrice composition of the present invention (the enamel of the tooth was abraded prior to brushing).

Detailed Description

The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention; it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by those skilled in the art without any inventive work are within the scope of the present invention.

In order to solve oral diseases such as tooth sensitivity, the composition disclosed by the invention adopts a combination technology of micron-sized precipitated silica and paeonol, wherein the specific parameters of the micron-sized precipitated silica are that the median particle size of D50 is 0.1-5 microns, and the particle size of D90 is less than or equal to 8 microns.

The action mechanism of the micron-sized silicon dioxide for dentin sensitivity is that the micron-sized silicon dioxide can block the small dental canal orifice, so that the originally exposed dental nerves are blocked, and the dental pulp nerves in the dental canal are prevented from being stimulated by external cold, hot, sour, sweet and the like to generate pain sensation. The electron microscope is shown in FIGS. 1 and 2.

FIG. 1: after brushing the surface with a piece of enamel removed from the tooth and a piece of toothpaste containing no precipitated silica, a microscopic image of the surface was observed with a scanning electron microscope and the surface was seen to be mostly bare.

FIG. 2: after brushing the surface with a piece of enamel removed from the tooth and with a toothpaste containing micron precipitated silica, a microscopic image of the surface was observed with a scanning electron microscope and it was seen that most of the tubules of the surface had been filled and sealed.

Paeonol, which is documented to have an effect on desensitization of teeth, is found to have an effective rate of 90% for desensitization of teeth as found in the research of the application research of supercritical extraction and extract of moutan bark, which is an article in the journal 2002, No. 4, page 33 of the toothpaste industry. The principle may be that paeonol has a certain anesthetic effect on dental nerves.

For the composition, it comprises a matrix and, in addition to the micron-sized precipitated silica as active ingredient and paeonol, it typically also comprises a matrix carrying the active ingredient.

Generally, the composition contains 0.1-30% of micron-sized precipitated silica and 0.1-5% of paeonol.

When the matrix is applied to toothpaste, the matrix specifically comprises 2-4% of PEG 400, 45-55% of sorbitol, 0.8-1% of thickening agent, 0.15-0.22% of saccharin sodium, 0.2-0.25% of sodium fluoride, 0.4-0.55% of titanium dioxide, 13-16% of friction type silicon dioxide, 0.18-0.22% of K12, 0.8-1.3% of essence, 0.09-0.12% of methyl hydroxybenzoate, 0.07-0.09% of propyl hydroxybenzoate and the balance of water.

When the matrix is applied to dentifrice, the matrix specifically comprises 0.08-0.12% of saccharin sodium, 0.18-0.21% of essence, 0.09-0.11% of methyl hydroxybenzoate, 0.07-0.09% of propyl hydroxybenzoate, and the balance of calcium hydrogen phosphate.

Example 1:

when the composition is prepared into toothpaste, the composition specifically comprises 3% of PEG 400, 50% of sorbitol, 0.9% of thickening agent, 0.2% of saccharin sodium, 0.23% of sodium fluoride, 0.5% of titanium dioxide, 15% of friction type silicon dioxide, 2% of K12, 1% of essence, 0.1% of methyl hydroxybenzoate, 0.08% of propyl hydroxybenzoate, 6% of micron precipitated silicon dioxide, 0.2% of paeonol and the balance of water.

The preparation process of the toothpaste comprises the following steps:

1. dissolving PEG-400, sorbitol, saccharin sodium and sodium fluoride in water.

2. Uniformly mixing titanium dioxide, friction type silicon dioxide, micron precipitated silicon dioxide, a thickening agent and K12, adding the solution obtained in the step 1, and uniformly stirring in vacuum to obtain an intermediate paste.

3. And (3) dissolving paeonol, methyl paraben and propyl paraben in essence, adding the solution into the intermediate paste body obtained in the step (2), and uniformly stirring in vacuum to obtain the final toothpaste body.

Example 2:

when the composition is prepared into dentifrice, the composition specifically comprises 0.1% of saccharin sodium, 0.2% of essence, 0.1% of methylparaben, 0.08% of propylparaben, 6% of micron precipitated silicon dioxide, 0.2% of paeonol and the balance of calcium hydrophosphate.

The preparation method of the dentifrice comprises the following steps:

1. mixing sodium fluoride, saccharin sodium and calcium hydrogen phosphate uniformly.

2. Dissolving paeonol, methyl hydroxybenzoate and propylparaben in essence, spraying the essence solution onto the powder obtained in step 1 with a sprayer, and stirring. The dentifrice preparation is complete.

For the product experiments of the above examples, the experimental effects are as follows:

product population experiment:

the product experiments are carried out in 3 groups of 20 people with oral cavity sensitivity problems, the toothpaste only added with one additive and the toothpaste simultaneously added with two additives are subjected to comparison experiments, and the final data show that the desensitization effect of the toothpaste simultaneously added with micron-sized silicon dioxide and paeonol is obviously higher than that of the toothpaste singly added with one of the active ingredients, and the experimental data are shown in the following table:

the test data in the table show that the effective rate of the micron-sized precipitated silica and the paeonol on dentin anti-sensitivity is obviously higher than that of the micron-sized precipitated silica and the paeonol which are used independently for one anti-sensitivity active substance, and the data show that the micron-sized precipitated silica and the paeonol have a synergistic effect on treatment.

Therefore, the invention combines the micron-sized precipitated silica and the paeonol, can simultaneously perform the functions of blocking and anaesthetizing the exposed dental nerves, and has very obvious effect of desensitizing the teeth.

Compared with the prior art, the composition has lasting and effective anti-allergy effect on teeth, and because the composition does not contain high-concentration potassium salt/strontium salt, the taste of the product is not influenced, the bitter taste is avoided, and meanwhile, the foam is rich and the use experience is good.

In addition, paeonol which is one of the active ingredients in the invention can be natural sources, such as moutan bark, paniculate swallowwort root and the like, and can also be synthesized. The paeonol in the present invention encompasses both sources, and encompasses different concentrations (both low concentrations of plant extracts containing paeonol, and pure amounts of paeonol).

The other active component micron-sized precipitated silica in the invention comprises micron-sized silica prepared by various chemical precipitation methods, wherein D50 medium-sized particles have a particle size of 0.1-5 microns, and D90 particle size is less than or equal to 8 microns.

The matrix carrying the effective components is not limited to the components of toothpaste or tooth powder, and can be liquid, namely prepared into spray, mouthwash and the like; it can also be made into candy base, i.e. food such as chewing gum.

The foregoing is only a preferred embodiment of the present invention; the scope of the invention is not limited thereto. Any person skilled in the art should be able to cover the technical scope of the present invention by equivalent or modified solutions and modifications within the technical scope of the present invention.

Claims

1. A composition for preventing or ameliorating oral diseases, characterized by: it comprises matrix, micron-sized precipitated silica as effective component, and paeonol.

2. A composition for preventing or ameliorating oral diseases according to claim 1 wherein: the oral disease is oral dentin hypersensitiveness.

3. A composition for preventing or ameliorating oral diseases according to claim 1, wherein: in the composition, the content of the micron-sized precipitated silica is 0.1-30%, and the content of the paeonol is 0.1-5%.

4. A composition for preventing or ameliorating oral diseases according to claim 3, wherein: the matrix specifically comprises 2 to 4 percent of PEG 400, 45 to 55 percent of sorbitol, 0.8 to 1 percent of thickening agent, 0.15 to 0.22 percent of saccharin sodium, 0.2 to 0.25 percent of sodium fluoride, 0.4 to 0.55 percent of titanium dioxide, 13 to 16 percent of friction type silicon dioxide, 0.18 to 0.22 percent of K12, 0.8 to 1.3 percent of essence, 0.09 to 0.12 percent of methyl hydroxybenzoate, 0.07 to 0.09 percent of hydroxyphenyl propyl ester, and the balance of water.

5. A composition for preventing or ameliorating oral diseases according to claim 3, wherein: the matrix comprises saccharin sodium 0.08-0.12%, essence 0.18-0.21%, methyl hydroxybenzoate 0.09-0.11%, propyl hydroxybenzoate 0.07-0.09%, and calcium hydrogen phosphate in balance.

6. The composition for preventing or ameliorating oral diseases according to claim 4, wherein: the composition specifically comprises 3% of PEG 400, 50% of sorbitol, 0.9% of thickening agent, 0.2% of saccharin sodium, 0.23% of sodium fluoride, 0.5% of titanium dioxide, 15% of friction type silicon dioxide, 2% of K12, 1% of essence, 0.1% of methyl hydroxybenzoate, 0.08% of propyl hydroxybenzoate, 6% of micron precipitated silicon dioxide, 0.2% of paeonol and the balance of water.

7. The composition for preventing or ameliorating oral diseases according to claim 5, wherein: the composition specifically comprises 0.1% of saccharin sodium, 0.2% of essence, 0.1% of methylparaben, 0.08% of propyl hydroxybenzoate, 6% of micron precipitated silicon dioxide, 0.2% of paeonol and the balance of calcium hydrophosphate.