CN1112010A - Compound traditional Chinese medicine preparation for treatment of osteoporosis and preparing method thereof - Google Patents
Compound traditional Chinese medicine preparation for treatment of osteoporosis and preparing method thereof Download PDFInfo
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- CN1112010A CN1112010A CN 95100697 CN95100697A CN1112010A CN 1112010 A CN1112010 A CN 1112010A CN 95100697 CN95100697 CN 95100697 CN 95100697 A CN95100697 A CN 95100697A CN 1112010 A CN1112010 A CN 1112010A
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Abstract
The Chinese-medicinal compound preparation for curing osteoporosis caused by different causes with ideal curative effect and low cost is prepared from cnidium fruit, epimedium and pearl powder. Another 10 optimal prescriptions for curing different osteoporosises are also disclosed.
Description
The present invention relates to treat the compound Chinese medicinal preparation and the method for making thereof of osteoporosis.
Osteoporosis is one of important diseases of harm humans health, aging along with population, the patient of primary osteoporosis is increasing, research has recently confirmed that also a lot of diseases also can cause secondary osteoporosis, particularly the multiple diseases such as renal osteodystrophy due to diabetes, disease of parathyroid glands, hyperthyroidism, chronic glomerulonephritis, the chronic pyelonephritis etc. all can cause osteoporosis, in addition, medicine is the prolonged application adrenocortical hormone particularly, the anticancer chemotherapy medicine, retinoic acid etc. also can cause serious osteoporosis.Therefore, prevention and treatment of osteoporosis becomes an important topic that urgency is to be solved.
Task of the present invention is a kind of compound preparation of being made up of pure Chinese medicine of development, and said preparation can stop further losing of sclerotin, can promote the formation of new bone again, and the osteoporosis due to a variety of causes is all had certain preventive effect and therapeutical effect.This subject study person has proved that a kind of composition that extracts has the effect of good protect against osteoporosis (seeing Chinese patent application 92105338.X) from the Chinese medicine Fructus Cnidii, Fructus Cnidii and other Chinese medicine have further been studies have shown that, the compound preparation formed of Herba Epimedii and Margarita layer powder particularly, osteoporosis to several animal models all has good preventive and therapeutic effect, provides new approach for solving the osteoporosis problem of preventing and treating.
The approach that solves this task is achieved in that gets the Chinese medicine Fructus Cnidii, and Herba Epimedii and Margarita layer powder three combine, and forms compound recipe, is made into Chinese medicinal tablet by following technology, and electuary or capsule are for clinical practice.Studies show that this preparation is to removal ovary, go the experimental osteoporosis due to the testis,, insufficiency of kidney-YANG osteoporosis due to the chemotherapeutic hydroxyurea etc. is all had good preventive and therapeutic effect the osteoporosis due to the prolonged application adrenocortical hormone.This preparation can stop further losing of sclerotin, promotes alcium and phosphor metabolization, promotes that blood calcium is converted into bone calcium, promotes new bone formation, makes loose osseous tissue become fine and close, and can eliminate the various untoward reaction due to the osteoporosis.There is no report with this compound preparation treatment osteoporosis domestic and foreign literature.
This compound preparation can prepare by following SOME METHODS:
1. get Fructus Cnidii 30～70%, Herba Epimedii 30～70% is pulverized or powder, adds 75～95% soak with ethanol 24 hours, filters, reclaim ethanol, it is standby to get ethanol extract, and medicinal residues decoct with water 3 times again, merge three times filtrate, filter, filtrate is concentrated in right amount, add Margarita layer powder 5～10% and aforesaid ethanol extract, cold drying, pulverize, add appropriate amount of auxiliary materials, make granule, tabletting, sugar coating or encapsulated, promptly.
2. get Fructus Cnidii and be ground into powder in right amount, with 0.5% caustic lye of soda heating extraction, extracting solution neutralizes back gained precipitate again with acetone treatment with acid, the extract obtained proper proportion of pressing adds in the Herba Epimedii extractum, and adds 5～15% Margarita layer powder, concentrate drying, add appropriate amount of auxiliary materials, make the granule tabletting, sugar coating or encapsulated, promptly.
3. get Fructus Cnidii 30～70%, Herba Epimedii 30～70% after pulverizing or shredding, decocts with water three times, and each 2 hours, merge three times decocting liquid, filter.Filtrate is condensed into the thick paste shape, adds Margarita layer powder, is dried to dry extract, adds appropriate amount of auxiliary materials, makes granule, tabletting, and sugar coating or encapsulated, promptly.
The goods that adopt above 1～3 method to make, through the pharmacology, toxicologic study proves, this product is to the osteoporosis due to the removal ovary, go the osteoporosis due to the testis, to the osteoporosis due to the prolonged application adrenocortical hormone, osteoporosis due to " insufficiency of kidney-YANG " due to the hydroxyurea there are splendid prevention and therapeutical effect, acute toxicity test and long term toxicity test (comprising 3 months to 6 months) confirm that all this product toxicity is low, take for a long time the heart, liver, kidney, lung, stomach, intestinal, spleen, thymus, the all harmless effect of each vitals such as lymph node.Clinical research shows, this product is to primary osteoporosis such as menopausal women and senile osteoporosis, and the osteoporosis of secondary osteoporosis such as hypercorticalismus disease, hyperthyroidism, hyperparathyroidism and drug-induced all has good preventive and therapeutic effect.
This preparation is added some Chinese prescription, osteoporosis to following some diseases or drug-induced can obtain better therapeutic effect, promptly in protect against osteoporosis, can treat targetedly protopathy again, untoward reaction to some drugs also has the better prevention effect, is exemplified below:
One. to the optimum formula of the control of diabetic osteoporosis disease
1. fill a prescription (1):, on the basis of the basic prescription that Herba Epimedii and Margarita layer powder are formed, add Radix Ginseng 3～8% again with Fructus Cnidii; Rhizoma Coptidis 5～15%; The Rhizoma Anemarrhenae 5～15%; Cortex Moutan 5～15% and Lien Sus domestica.After the compound preparation that this prescription is made into by aforementioned technology, concentrate drying become dried cream, add Lien Sus domestica powder 5～10%, make granule, tabletting, sugar coating or encapsulated.Clinical observation shows, this preparation is better to the curative effect of the osteoporosis due to the diabetes.
2. fill a prescription (2):, on the basis of the basic prescription that Herba Epimedii and Margarita layer powder are formed, add Radix Salviae Miltiorrhizae 5～15% again with Fructus Cnidii; The Radix Astragali 5～15%; Fructus Schisandrae Chinensis 5～15%; Radix Notoginseng 3～5%.This prescription is made compound preparation by prescription (1) described technology, and is better to the therapeutic effect of the secondary osteoporosis due to the diabetes, can prevent the generation and the development of osteoporosis card at etiological treatment again.
Two. to the optimum formula of the osteoporosis due to the prolonged application glucocorticoid:
1. prescription (3): with Fructus Cnidii, Herba Epimedii and Margarita layer powder are on the basis of basis side, add the Radix Astragali 5～15%; The Rhizoma Atractylodis Macrocephalae 5～15%; The Rhizoma Anemarrhenae 5～15%.Make compound preparation by aforesaid technology, said preparation and adrenocortical hormone share, but the antiinflammatory action of adrenal cortex reinforcing hormone can resist various untoward reaction, particularly osteoporosis due to the adrenocortical hormone again.
2. prescription (4): with Fructus Cnidii, Herba Epimedii and Margarita layer powder are on the basis of basis side, add the Radix Rehmanniae 5～15%, Fructus Psoraleae 5～15%, Radix Aconiti Lateralis Preparata 3～5%, Radix Glycyrrhizae 3～5%.Make compound preparation by aforementioned technology, said preparation has splendid antagonism to osteoporosis and other untoward reaction due to the adrenocortical hormone.
Three. to the optimum formula of menopausal women osteoporosis:
1. prescription (5): with Fructus Cnidii, Herba Epimedii and Margarita layer powder are on the basis of basis side, add Radix Salviae Miltiorrhizae 5～15%, Rhizoma Cimicifugae 5～15%, Radix Et Rhizoma Rhei 5～15%.Make compound preparation by aforementioned technology.This preparation has splendid therapeutic effect to the patient of menopausal women and senile osteoporosis.
2. prescription (6): with Fructus Cnidii, Herba Epimedii and Margarita layer powder are on the basis of basis side, add Radix Ginseng 3～8%; Rhizoma Osmundae 5～15%, Rhizoma Cyperi 3～15%; Fructus Psoraleae 5～15%.Make compound preparation by aforementioned technology, this preparation has splendid therapeutic effect to the patient of menopausal women and senile osteoporosis.
Four. to the optimum formula of the osteoporosis due to the anticancer chemotherapy medicine:
1. prescription (7): with Fructus Cnidii, Herba Epimedii and Margarita layer powder are on the basis of basis side, add Radix Et Caulis Acanthopanacis Senticosi 5～15%; Caulis Spatholobi 5～15%; The Radix Astragali 5～15%; Radix Angelicae Sinensis 5～15%.Make compound preparation by aforementioned technology, this preparation has antagonism preferably to the osteoporosis due to the prolonged application anticarcinogen chemotherapy and the bone marrow depression due to the chemotherapeutic and gastrointestinal reaction.
2. prescription (8): with Fructus Cnidii, Herba Epimedii and Margarita layer powder are on the basis of basis side, add Fructus Ligustri Lucidi 5～15%; Rhizoma Polygoni Cuspidati 5～15%; Fructus Jujubae 5～15%; The Rhizoma Pinelliae 5～15%.Make compound preparation by aforementioned technology, this preparation to long-term with the osteoporosis due to the anticarcinogen chemotherapy and the better prevention effect of leukopenia due to the chemotherapeutic and gastrointestinal reaction.
Five. the optimum formula of the osteoporosis due to the control hyperthyroidism:
1. prescription (9): with Fructus Cnidii, Herba Epimedii and Margarita layer powder are on the basis of basis side, add Rhizoma Cimicifugae 5～15%; Radix Puerariae 5～15%; Cortex Moutan 5～15%.Make compound preparation by aforementioned technology, this preparation has fabulous preventive and therapeutic effect to the osteoporosis due to the hyperthyroidism.
Six. the optimum formula of the osteoporosis due to the control renal osteodystrophy:
1. prescription (10): with Fructus Cnidii, Herba Epimedii and Margarita layer powder be on the basis of basis side, the interpolation vitamin B
, vitamin C and vitamin D.Make compound Chinese medicinal preparation by preceding method, every tablet or capsule include vitamin B
10～25mg, vitamin C 100～200mg, vitamin D2～30,000 IU.This prescription has preferable curative effect to the osteoporosis due to the renal osteodystrophy.
Seven, protect against osteoporosis and the optimum formula of obvious lumbago disease is arranged:
Prescription (11): at Fructus Cnidii, Herba Epimedii and Margarita layer powder is on the basis of basis side, adds Rhizoma Corydalis, makes compound Chinese medicinal preparation by preceding method.Herba Epimedii, Fructus Cnidii and Rhizoma Corydalis are formed in 1: 1: 1 ratio.This preparation follows obvious lumbago person's curative effect very remarkable to osteoporosis.
Eight, the optimum formula of the osteoporosis due to control " suffering from a deficiency of the kidney " disease
Prescription (12): be on the basis of basis side with the Herba Epimedii, adding the Radix Astragali, Rhizoma Atractylodis Macrocephalae replacement Fructus Cnidii and Margarita layer powder; Herba Epimedii, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae are formed in 1: 1: 1 ratio.Make capsule or electuary as stated above, clinical observation has significant curative effect to the osteoporosis due to suffering from a deficiency of the kidney.
In sum, with Fructus Cnidii, the compound preparation that Herba Epimedii and Margarita layer powder are formed all has curative effect preferably to the osteoporosis due to a variety of causes, adds some other drugs on this basis, its to some specific disease because of the osteoporosis curative effect better.The proposition of this compound preparation can be the clinical treatment osteoporosis good curing articles for use is provided.
Above-mentioned preparation is through further technological transformation, can be made into injection and is used for clinically, also can be made into electuary, oral liquid, beverage, health promoting wine etc. and is used for clinical.
Claims (4)
1, the osteoporotic compound Chinese medicinal preparation of a kind of treatment is characterized in that this Chinese medicine compound contains Herba Epimedii 20～70%; Fructus Cnidii 20～70% and Margarita layer powder 5～20%, its method for making can make by following three kinds of methods;
A, get Herba Epimedii and Fructus Cnidii shreds respectively or pulverizes, add 70～95% ethanol extractions 24 hours, filter, reclaim ethanol, it is standby to get ethanol extract, and medicinal residues decoct with water 3 times again, merge three times filtrate, filter, concentrate, add Margarita layer powder and aforementioned ethanol extract, cold drying is pulverized, add appropriate amount of auxiliary materials, make granule, tabletting, sugar coating or encapsulated, promptly;
B, get Fructus Cnidii with 0.5% sodium hydroxide heating extraction, extracting solution neutralizes back gained precipitate again with acetone treatment with acid, extract obtained by in the proper proportion adding Herba Epimedii extractum, and adding Margarita layer powder, concentrate drying, add appropriate amount of auxiliary materials, make granule tabletting, sugar coating or encapsulated, that is:
C, Herba Epimedii, Fructus Cnidii are cleaned chopping or pulverize, extracting in water is 3 times respectively, and each 2 hours, merges three times filtrate, filter, concentrate, add Margarita layer powder, to dry for 80 ℃, pulverizing divides encapsulated or tabletting, promptly.
2, the compound Chinese medicinal preparation of treatment osteoporosis as claimed in claim 1 is characterized in that the different causes of disease according to osteoporosis, also can increase following Chinese medicine and form optimum formula:
A, increase Radix Ginseng 3～8%, Rhizoma Coptidis 5～15%, the Rhizoma Anemarrhenae 5～15%, Cortex Moutan 5～15%, Lien Sus domestica dry powder 5～15%, or increase the optimum formula that Radix Salviae Miltiorrhizae 5～15%, the Radix Astragali 5～15%, Fructus Schisandrae Chinensis 5～15%, Radix Notoginseng 3～5% are formed the treatment diabetic osteoporosis;
B, increase the Radix Astragali 5～15%, the Rhizoma Atractylodis Macrocephalae 5～15%, the Rhizoma Anemarrhenae 5～15%, or increase the Radix Rehmanniae 5～15%, Fructus Psoraleae 5～15%, Radix Aconiti Lateralis Preparata 3～5%, Radix Glycyrrhizae 3～5%, form osteoporotic optimum formula due to the treatment prolonged application adrenocortical hormone;
C, increase Radix Salviae Miltiorrhizae 5～15%, Rhizoma Cimicifugae 5～15%, Radix Et Rhizoma Rhei 5～15%, or increase Radix Ginseng 3～8%, Rhizoma Osmundae 5～15%, Rhizoma Cyperi 3～5%, Fructus Psoraleae 5～15%, form the optimum formula of treatment menopausal women and senile osteoporosis;
D, increase Radix Et Caulis Acanthopanacis Senticosi 5～15%, Caulis Spatholobi 5～15%, the Radix Astragali 5～15%, Radix Angelicae Sinensis 5～15% or increase Fructus Ligustri Lucidi 5～15%, Rhizoma Polygoni Cuspidati 5～15%, Fructus Jujubae 5～15%, the Rhizoma Pinelliae 5～15% are formed the optimum formula of the osteoporosis due to the prolonged application anticarcinogen chemotherapy;
E, increase Rhizoma Cimicifugae 5～15%, Radix Puerariae 5～15%, Cortex Moutan 5～15% are formed the optimum formula of the osteoporosis due to the treatment hyperthyroidism;
F, every or every increase vitamin B
10～25mg, vitamin C 100～200mg, vitamin D 2～30,000 IU form the osteoporotic optimum formula due to the control renal osteodystrophy.
3, the Chinese medicine preparation of the treatment osteoporosis of forming by Herba Epimedii, Fructus Cnidii, Margarita layer powder according to claim 1, the optimum formula that it is characterized in that treating the osteoporosis due to suffering from a deficiency of the kidney can replace Fructus Cnidii and Margarita layer powder by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, and Herba Epimedii, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae are formed optimum formula by 1: 1: 1 proportioning.
4, the Chinese medicine preparation of the treatment osteoporosis of being made up of Herba Epimedii, Fructus Cnidii, Margarita layer powder as claimed in claim 1 is characterized in that its optimum formula can increase Rhizoma Corydalis, and Herba Epimedii, Fructus Cnidii, Rhizoma Corydalis are formed optimum formula by 1: 1: 1 proportioning.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 95100697 CN1112010A (en) | 1995-03-24 | 1995-03-24 | Compound traditional Chinese medicine preparation for treatment of osteoporosis and preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 95100697 CN1112010A (en) | 1995-03-24 | 1995-03-24 | Compound traditional Chinese medicine preparation for treatment of osteoporosis and preparing method thereof |
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| CN 95100697 Pending CN1112010A (en) | 1995-03-24 | 1995-03-24 | Compound traditional Chinese medicine preparation for treatment of osteoporosis and preparing method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003105829A1 (en) * | 2002-06-18 | 2003-12-24 | Shanghai Institute Of Pharmaceutical Industry | A formulation of traditional chinese medicine for preventing and treating osteoporosis |
| CN1313111C (en) * | 2004-05-13 | 2007-05-02 | 中国人民解放军第二军医大学 | Chinese medicinal extract for resisting osteoporosis and its preparation |
| CN100342870C (en) * | 2005-08-25 | 2007-10-17 | 广东医学院 | Pain-alleviating inflammation-relieving Chinese medicinal plaster for treating osteoporosis |
| CN101204432B (en) * | 2007-12-19 | 2010-11-10 | 天津太平洋制药有限公司 | Chinese traditional medicine oral liquid preparation for osteoporosis and preparation method thereof |
| CN104147073A (en) * | 2014-08-13 | 2014-11-19 | 湛江广医医药科技开发有限公司 | Traditional Chinese medicine preparation formula capable of warming kidney and invigorating yang as well as preventing and treating osteoporosis, production technology and application thereof |
| CN104397284A (en) * | 2014-11-27 | 2015-03-11 | 青岛申达高新技术开发有限公司 | Kidney tonifying and bone strengthening eleutherococcus senticosus health tea and preparation method thereof |
| CN111494405A (en) * | 2020-05-07 | 2020-08-07 | 贵州中医药大学 | Application of astragalus polysaccharide in preventing and treating glucocorticoid-induced osteoporosis |
-
1995
- 1995-03-24 CN CN 95100697 patent/CN1112010A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003105829A1 (en) * | 2002-06-18 | 2003-12-24 | Shanghai Institute Of Pharmaceutical Industry | A formulation of traditional chinese medicine for preventing and treating osteoporosis |
| CN1313111C (en) * | 2004-05-13 | 2007-05-02 | 中国人民解放军第二军医大学 | Chinese medicinal extract for resisting osteoporosis and its preparation |
| CN100342870C (en) * | 2005-08-25 | 2007-10-17 | 广东医学院 | Pain-alleviating inflammation-relieving Chinese medicinal plaster for treating osteoporosis |
| CN101204432B (en) * | 2007-12-19 | 2010-11-10 | 天津太平洋制药有限公司 | Chinese traditional medicine oral liquid preparation for osteoporosis and preparation method thereof |
| CN104147073A (en) * | 2014-08-13 | 2014-11-19 | 湛江广医医药科技开发有限公司 | Traditional Chinese medicine preparation formula capable of warming kidney and invigorating yang as well as preventing and treating osteoporosis, production technology and application thereof |
| CN104397284A (en) * | 2014-11-27 | 2015-03-11 | 青岛申达高新技术开发有限公司 | Kidney tonifying and bone strengthening eleutherococcus senticosus health tea and preparation method thereof |
| CN111494405A (en) * | 2020-05-07 | 2020-08-07 | 贵州中医药大学 | Application of astragalus polysaccharide in preventing and treating glucocorticoid-induced osteoporosis |
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