CN111166698A - Chinese medicinal toothpaste containing radix et rhizoma Rhei, and its preparation method - Google Patents
Chinese medicinal toothpaste containing radix et rhizoma Rhei, and its preparation method Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention provides a Chinese herbal medicine toothpaste, which is added with cooked rhubarb powder and traditional Chinese medicine extract extracted from coptis chinensis, tree peony bark and angelica, and the rhubarb powder is used as an abrasive, so that the toothpaste has a good cleaning effect and a good effect of treating oral diseases.
Description
Technical Field
The invention relates to toothpaste, in particular to medicinal toothpaste.
Background
The survey report of the national oral health status in 2017 shows that: 91.6% of the population under investigation had suffered from oral problems, with a proportion of 92.0% female users and 91.4% male users, and there was no significant gender difference between men and women in terms of oral problems.
At present, the existing innovative toothpaste in the market mainly comprises: soda toothpaste, bamboo charcoal toothpaste, probiotic toothpaste, pregnant woman toothpaste, infant toothpaste, etc.
The toothpaste is composed of powder abrasive, humectant, surfactant, binder, perfume, sweetener and other special components. Wherein, the common powdery abradant mainly comprises calcium carbonate, calcium hydrophosphate, calcium pyrophosphate, hydrated silicic acid and aluminum hydroxide, and is respectively suitable for common toothpaste, stain-removing toothpaste, fluorine-containing toothpaste, transparent toothpaste and the like.
However, the toothpaste is mainly used for whitening or cleaning, and cannot treat periodontal diseases due to the addition of the powdery abrasive. The toothpaste in the market is less and is realized by adding some liquid traditional Chinese medicine extracts if the toothpaste exists, and the treatment principle of the toothpaste is mainly the efficacy of medicinal components. However, the periodontal disease is caused by the disorder of the zang-fu organs, and also caused by the adhesion of more stains to the teeth, especially the root position, and the therapeutic effect is not good because the conventional medicinal toothpaste is in a liquid state and contains less medicinal components, and is difficult to be brought into full contact with the teeth, especially the root position, within a short period of time during which the toothpaste is in contact with the teeth in the oral cavity.
Disclosure of Invention
The invention aims to provide rhubarb-containing traditional Chinese medicine toothpaste for solving the technical problem that the existing medicinal toothpaste is poor in effect of treating oral diseases.
In order to achieve the above purpose, the invention provides the following technical scheme:
a Chinese medicinal toothpaste containing radix et rhizoma Rhei comprises Chinese medicinal components and adjuvants; wherein:
the traditional Chinese medicine component accounts for 0.5-2% of the toothpaste in percentage by weight, the traditional Chinese medicine component is a mixture of cooked rhubarb powder and traditional Chinese medicine extract, and the traditional Chinese medicine extract is prepared from coptis chinensis, moutan bark and angelica;
the auxiliary materials at least comprise a thickening agent, a surfactant, a wetting agent, a foaming agent, a binding agent, a sweetening agent and deionized water.
Meanwhile, the invention also discloses a preparation process of the rhubarb toothpaste, which comprises the following steps:
mixing cooked radix et rhizoma Rhei powder and Chinese medicinal extractive solution to obtain Chinese medicinal components;
the preparation process of the cooked rhubarb powder comprises the following steps:
cutting radix et rhizoma Rhei into slices with thickness of 0.5-1.0cm, and drying at 55-60 deg.C;
drying slices per kilogram of rhubarb, and mixing with yellow wine: soaking the rheum officinale slices for 30 minutes by using yellow wine solution with the water mass part ratio of (0.3: 0.3-0.7);
steaming the soaked rhubarb slices for 4 hours to obtain clean rhubarb slices;
drying the clean rhubarb slices at 55-60 ℃ until the drying moisture is within 4 percent to obtain dry paste;
drying the dry paste to room temperature, crushing, and sieving by 60-80 meshes;
the preparation process of the traditional Chinese medicine extracting solution comprises the following steps:
mixing Coptidis rhizoma, cortex moutan, radix Angelicae sinensis, Coptidis rhizoma and cortex moutan at a weight ratio of 2:3:2, decocting with water, filtering, and concentrating to relative density of 1.2-1.3; adding ethanol into radix Angelicae sinensis to make ethanol content reach 70%, standing, and concentrating the supernatant to relative density of 1.2-1.3;
the toothpaste is obtained by uniformly mixing the traditional Chinese medicine components and auxiliary materials, wherein the traditional Chinese medicine components account for 0.5-2% of the toothpaste by weight, and the auxiliary materials at least comprise a thickening agent, a surfactant, a wetting agent, a foaming agent, an adhesive, a sweetening agent and deionized water.
Has the advantages that:
the invention relates to a Chinese herbal medicine toothpaste, which is added with cooked rhubarb powder and traditional Chinese medicine extract extracted from coptis chinensis, tree peony bark and angelica, wherein in the formula, the rhubarb, the tree peony bark and the angelica act on upper jiao, and the coptis chinensis acts on middle jiao; in the formula, the rhubarb is used as the monarch drug for cooling blood and removing toxicity to dissipate fire of upwelling inflammation; the cortex moutan is used for cooling blood and clearing heat as a minister; and radix Angelicae sinensis has effects of nourishing blood and regulating blood; coptis root, rhizoma Coptidis, being bitter and cold in nature, purges fire to remove heat accumulated in stomach; 4 herbs in combination have the actions of cooling blood and clearing stomach.
Radix et rhizoma Rhei contains aloe-emodin, rhein, emodin, chrysophanol, and physcion. The chemical components of coptis root are mainly alkaloids. The cortex moutan mainly contains phenol and phenolic glycoside compounds, such as paeonol, monoterpene and its glycosides, such as paeoniflorin. The radix Angelicae sinensis mainly contains phenolic acid compounds, has high volatile oil content, and contains ligustilide and ferulic acid as main ingredients. Rhubarb is the fire which can cool blood, remove toxicity and dispel inflammation by the monarch drug; cortex moutan is used as minister to cool blood and clear heat; and radix Angelicae sinensis has effects of nourishing blood and regulating blood; coptis root, rhizoma Coptidis, being bitter and cold in nature, purges fire to remove heat accumulated in stomach; the four herbs are combined together to have the actions of cooling blood and clearing stomach. Can be used for treating stomach fire toothache, oral ulcer, halitosis, and periodontitis.
The raw rhubarb, bitter in flavor and cold in property, subsides, smells heavy and turbid, goes out of the way and directly goes to the lower energizer, and has strong purgative effect. The prepared rhubarb steamed with wine has mild purgation effect and can enhance the functions of promoting blood circulation and removing blood stasis, and compared with the raw rhubarb, the prepared rhubarb is more suitable for treating diseases such as stomach fire toothache, oral ulcer, halitosis, periodontitis and the like without causing diarrhea.
Meanwhile, the rhubarb is in a powder form by utilizing the characteristic that the rhubarb is harder, so that the friction on teeth is realized, the traditional friction agent can be replaced, the tooth cleaning capability is higher, the enamel on the surface of the teeth is not abraded, and the soft tissues in the oral cavity are not damaged; after the rubbing, the original dirt attached position on the tooth surface, especially the tooth root can be more fully contacted with the medicinal powder, so that the medicinal effect of the medicinal powder can directly reach the tooth root, and the medicinal powder can better act on the gum.
It should be understood that all combinations of the foregoing concepts and additional concepts described in greater detail below can be considered as part of the inventive subject matter of this disclosure unless such concepts are mutually inconsistent.
The foregoing and other aspects, embodiments and features of the present teachings will be more fully understood from the following description. Additional aspects of the present invention, such as features and/or advantages of exemplary embodiments, will be apparent from the description which follows, or may be learned by practice of specific embodiments in accordance with the teachings of the present invention.
Detailed Description
In order to better understand the technical content of the present invention, specific embodiments are specifically illustrated as follows.
Embodiments of the present disclosure are not necessarily intended to include all aspects of the invention. It should be appreciated that the various concepts and embodiments described above, as well as those described in greater detail below, may be implemented in any of numerous ways, as the disclosed concepts and embodiments are not limited to any one implementation. In addition, some aspects of the present disclosure may be used alone, or in any suitable combination with other aspects of the present disclosure.
A traditional Chinese medicine toothpaste containing radix et rhizoma Rhei comprises traditional Chinese medicine components and adjuvants. Wherein:
the traditional Chinese medicine component accounts for 0.5-2% of the toothpaste in percentage by weight, the traditional Chinese medicine component is a mixture of cooked rhubarb powder and traditional Chinese medicine extract, and the traditional Chinese medicine extract is prepared from coptis chinensis, moutan bark and angelica.
The auxiliary materials at least comprise a thickening agent, a surfactant, a wetting agent, a foaming agent, a binding agent, a sweetening agent and deionized water.
Further, in the above embodiment, the ratio of the cooked rhubarb powder, the coptis root, the moutan bark and the angelica is 5:2:3:2 by weight. For example, 15g of cooked rhubarb powder, 6g of coptis root, 9g of moutan bark and 6g of angelica are taken.
Furthermore, the powder of the cooked rhubarb in the above embodiment is 60 to 80 meshes. If too thick, it will damage enamel and the drug effect will not be exerted easily, and if too thin, it will not exert the rubbing effect.
Further, in the above embodiment, the Chinese medicinal extract is an extract with a relative density of 1.2-1.3.
Further, in the above embodiment, the auxiliary material further includes essence and preservative.
The preparation process of the embodiment of the invention is as follows:
mixing the cooked radix et rhizoma Rhei powder and the Chinese medicinal extractive solution to obtain Chinese medicinal components.
The preparation process of the cooked rhubarb powder comprises the following steps:
cutting radix et rhizoma Rhei into slices with thickness of 0.5-1.0cm and drying at 55-60 deg.C.
Drying slices per kilogram of rhubarb, and mixing with yellow wine: soaking the rheum officinale slices for 30 minutes by using yellow wine solution with the water mass portion ratio of (0.3: 0.3-0.7).
Steaming the soaked rhubarb slices for 4 hours to obtain clean rhubarb slices; in order to ensure the steaming quality, the steaming amount of each pot is controlled not to exceed 150 kg.
Drying the clean rhubarb slices at 55-60 ℃, specifically spreading the steamed clean rhubarb slices and drying the steamed clean rhubarb slices in a baking tray of a dryer until the drying moisture is within 4 percent to obtain dry paste.
Drying the dry paste to room temperature, crushing, and sieving by 60-80 meshes, preferably 80 meshes.
The preparation process of the traditional Chinese medicine extracting solution comprises the following steps:
mixing Coptidis rhizoma, cortex moutan, radix Angelicae sinensis, Coptidis rhizoma and cortex moutan at a weight ratio of 2:3:2, decocting with water, filtering, and concentrating to relative density of 1.2-1.3; adding ethanol into radix Angelicae sinensis to make ethanol content reach 70%, standing for 45 hr, and concentrating the supernatant to obtain extract with relative density of 1.2-1.3.
The toothpaste is obtained by uniformly mixing the traditional Chinese medicine components and auxiliary materials, wherein the traditional Chinese medicine components account for 0.5-2% of the toothpaste by weight, the auxiliary materials at least comprise a thickening agent, a surfactant, a wetting agent, a foaming agent, an adhesive, a sweetening agent and deionized water, and essence and a preservative can be added for adjusting the mouthfeel and storage, and sodium hydroxide can be added for adjusting the oral environment.
Specifically, 1g of the traditional Chinese medicine component is taken, 0.6g of xanthan gum is taken as a thickening agent, 2.5g of sodium dodecyl sulfate is taken as a surfactant, 10g of glycerin is taken as a wetting agent, 0.3g of sodium lauryl sulfate is taken as a foaming agent, 0.3g of sodium carboxymethylcellulose is taken as an adhesive, 1g of xylitol is taken as a sweetening agent, 1.1g of mint essence is taken as an essence, 0.1g of sodium paraben is taken as a preservative, 0.04g of sodium hydroxide and a plurality of deionized water are taken as the preservative.
The traditional auxiliary materials usually relate to sucrose, dextrin and starch, the sucrose has hygroscopicity, patients with diabetes, obesity, hypertension, coronary heart disease, decayed tooth and the like are not suitable for taking for a long time, and the dissolving property of the dextrin and the starch is not ideal. The xylitol in the toothpaste is used as a substitute of sugar, has the physicochemical properties similar to those of cane sugar, has the function of flavoring, can be used by diabetics for a long time, and also has the functions of inhibiting the growth of bacteria, destroying the formation of bacterial plaque, influencing the transportation of the bacteria to the cane sugar and reducing the acid production capability of the bacteria, thereby having obvious inhibiting effect on caries.
The mixing steps of the raw materials are as follows:
weighing sodium butylparaben, dissolving with purified water at normal temperature to obtain a first solution;
dissolving the Chinese medicinal materials, xylitol and sodium hydroxide with purified water at 50 deg.C, and stirring to obtain a second solution.
Adding xanthan gum, sodium carboxymethylcellulose and sodium lauryl sulfate into glycerol, uniformly stirring, adding the second solution, uniformly stirring, adding the first solution, uniformly stirring, standing for about 12-18 hours to obtain a uniform colloid;
stirring the colloid uniformly, adding sodium dodecyl sulfate and mint essence, stirring uniformly, and vacuumizing to a vacuum degree of 0.094 MPa.
Animal testing
100 SD rats are randomly divided into normal control group, model group, positive control group (compound toothache tincture, 500mg/kg), low (200mg/kg) and high (400mg/kg) dosage groups, and each group contains 20 rats.
Except for the normal control group, the rats of the other groups induced a periodontitis model by ligation and porphyromonas gingivalis infection, the rats were anesthetized by intraperitoneal injection with 10% chloral hydrate (0.3ml/100g), the neck region of the 2 nd molar of the upper jaw was bilaterally ligated with a No. 5-0 nylon thread, and the cheek and gingival sulcus of the 2 nd molar of the rats were inoculated 4 times with 20 μ l of porphyromonas gingivalis every 1 day.
Normal control animals underwent the same procedure as nylon thread ligation of the maxillary 2 nd molar neck region (not ligated) and were inoculated with 20. mu.l of 0.01mol/L Phosphate Buffered Saline (PBS). After feeding the diet for 4 weeks, the rats were anesthetized and the ligature was removed, and each administration group was gavaged with the corresponding drug, and the normal control group and the model group were given an equal amount of physiological saline for 4 weeks.
All rats were sacrificed and gingival tissue from the unilateral maxillary molars 2 of each rat was collected and stored at-80 ℃. Gingival-free maxillary tissue was fixed in 4% paraformaldehyde and alveolar bone loss was assessed using microcomputer tomography. The opposite maxillary tissues were fixed in 4% paraformaldehyde for histological and immunohistochemical analysis.
after the experiment is finished, the distance from the enamel cementum boundary to the crest of the alveolar ridge (ACJ-AC), the bone absorption area of the root bifurcation area, the level of monocytes and osteoclasts of gingival tissues, the level of nuclear factor-kB (NF-kB) of periodontal tissues, NLR P3mRNA and protein level, the expression level of interleukin 2(IL-2), interleukin 6(IL-6) and tumor necrosis factor- α (TNF- α) protein are measured.
1.1 Effect on rat ACJ-AC distance, area of bone resorption in the root bifurcation, data are presented in Table 1.
As can be seen from Table 1, compared with the normal control group, the model group has significantly increased ACJ-AC distance and bone absorption area in the root bifurcation region (P is less than 0.05); compared with the model group, the compound toothache tincture group, the ACJ-AC distance of each dosage group of the traditional Chinese medicine components and the bone absorption area of the root bifurcation area are obviously reduced (P is less than 0.05); and with the increase of the dosage of the traditional Chinese medicine components, the distance between ACJ and AC and the bone absorption area of the root bifurcation area are gradually reduced (P is less than 0.05); compared with the compound toothache tincture group, the ACJ-AC distance and the bone absorption area of the root bifurcation area of each dosage group of the traditional Chinese medicine components are obviously increased (P is less than 0.05).
TABLE 1
1.2 Effect on rat periodontal tissue monocyte and osteoclast levels, data are shown in Table 2.
As can be seen from Table 2, the number of monocytes and osteoclasts in the model group was significantly increased (P < 0.05) compared with the normal control group; compared with the model group, the compound toothache tincture group and the traditional Chinese medicine ingredient groups have obviously reduced monocyte and osteoclast numbers (P is less than 0.05), and the monocyte and osteoclast numbers are gradually reduced (P is less than 0.05) along with the increase of the dosage of the traditional Chinese medicine ingredient; compared with the compound toothache tincture, the traditional Chinese medicine components of each dosage group have obviously increased monocyte and osteoclast numbers (P is less than 0.05).
TABLE 2
1.3 Effect on rat periodontal tissue NF-. kappa.B and NLRP3mR-NA expression, data are presented in Table 3.
Compared with a normal control group, the model group has obviously increased expression levels of NF-kB and NLRP3mRNA (P is less than 0.05); compared with the model group, the NF-kB and NL-RP3m RNA expression levels of the compound toothache tincture group and the traditional Chinese medicine component dose groups are obviously reduced (P is less than 0.05), and the NF-kB and NL RP3mRNA expression levels are gradually reduced (P is less than 0.05) along with the increase of the traditional Chinese medicine component doses; compared with the compound toothache tincture group, the expression level of NF-kB and NLRP3mRNA of each dose group of the traditional Chinese medicine components is obviously increased (P is less than 0.05).
TABLE 3
1.4 Effect on rat periodontal IL-2, IL-6, TNF- α protein expression, data are shown in Table 4.
As can be seen from Table 4, the expression levels of IL-2, IL-6 and TNF- α proteins in the model group were significantly increased (P < 0.05) compared with the normal control group, the expression levels of IL-2, IL-6 and TNF- α proteins in the compound toothache tincture group and the Chinese medicinal component groups were significantly decreased (P < 0.05), and the expression levels of IL-2, IL-6 and TNF- α proteins in the compound toothache tincture group were gradually decreased (P < 0.05) with the increase of the Chinese medicinal component dosage, and the expression levels of IL-2, IL-6 and TNF- α proteins in the Chinese medicinal component groups were significantly increased (P < 0.05) compared with the compound toothache tincture group.
TABLE 4
In addition to the animal tests, 200 artificial test objects with various oral diseases such as tooth 40806 bleeding, gum swelling and pain, oral ulcer, gingival atrophy, periodontitis and the like are adopted, each person brushes the teeth with the toothpaste once every morning and evening, about 2g of the toothpaste is used once, after 7 days continuously, 98 percent of patients have obvious effect after using the toothpaste, 1 to 2 percent of the patients have common effect, and 1 to 2 percent of the patients show improvement.
Some clinical trial examples:
liu Zhi 1979, with symptoms: tooth 40806; the toothpaste is used for brushing teeth once in the morning and at night every day, and after the toothpaste is continuously used for 7 days, the gum does not bleed any more and has no adverse reaction.
Muozhi, 1993, with symptoms: swelling and aching of gum, bleeding gum, hot and smelly breath; the toothpaste is used for brushing teeth once in the morning and at night every day, and after the toothpaste is continuously used for 10 days, the relief is obvious.
Lie in 1980, symptoms: periodontitis has been known for many years; the toothpaste is used for brushing teeth once in the morning and at night every day, and the relief is obvious after the toothpaste is continuously used for 15 days.
Sun you 1969, symptoms: hot and smelly breath; the toothpaste is used for brushing teeth once in the morning and at night every day, and the effect is obvious after the toothpaste is continuously used for 7 days.
Wangzhi 1979, symptoms: tooth 40806; the toothpaste is used for brushing teeth once in the morning and at night every day, and after the toothpaste is continuously used for 7 days, the gum does not bleed any more, and no adverse reaction occurs.
Horse born 1984 with symptoms: tooth 40806; redness and swelling of the gums; the toothpaste is used for brushing teeth once in the morning and at night every day, and after the toothpaste is continuously used for 3 days, the gum does not bleed any more, and no adverse reaction occurs.
Zhuyao 1977, symptoms: tooth 40806; the toothpaste is used for brushing teeth once in the morning and at night every day, and after the toothpaste is continuously used for 2 days, the gum does not bleed any more, and no adverse reaction occurs.
Sheng in 1975, symptoms: tooth 40806; the toothpaste is used for brushing teeth once in the morning and at night every day, and after the toothpaste is continuously used for 7 days, the gum does not bleed any more, and no adverse reaction occurs.
Adult 1972, symptoms: repeated dental ulcer; the toothpaste is used for brushing teeth once in the morning and at night every day, and after the toothpaste is continuously used for 7 days, the ulcer disappears and no adverse reaction occurs.
Panda 1992, symptoms: bleeding of the teeth; the toothpaste is used for brushing teeth once in the morning and at night every day, and after the toothpaste is continuously used for 3 days, the gum does not bleed any more, and no adverse reaction occurs.
Zhao somewhat 1974, with symptoms: hot and smelly breath; the toothpaste is used for brushing teeth once in the morning and at night every day, and the effect is obvious after the toothpaste is continuously used for 5 days.
Although the present invention has been described with reference to the preferred embodiments, it is not intended to be limited thereto. Those skilled in the art can make various changes and modifications without departing from the spirit and scope of the invention. Therefore, the protection scope of the present invention should be determined by the appended claims.
Claims (6)
1. A traditional Chinese medicine toothpaste containing rhubarb is characterized in that: the components of the toothpaste comprise traditional Chinese medicine components and auxiliary materials; wherein:
the traditional Chinese medicine component accounts for 0.5-2% of the toothpaste in percentage by weight, the traditional Chinese medicine component is a mixture of cooked rhubarb powder and traditional Chinese medicine extract, and the traditional Chinese medicine extract is prepared from coptis chinensis, moutan bark and angelica;
the auxiliary materials at least comprise a thickening agent, a surfactant, a wetting agent, a foaming agent, a binding agent, a sweetening agent and deionized water.
2. The rhubarb-containing traditional Chinese medicine toothpaste according to claim 1, which is characterized in that: the weight part ratio of the cooked rhubarb powder, the coptis chinensis, the tree peony bark and the angelica is 5:2:3: 2.
3. The rhubarb-containing traditional Chinese medicine toothpaste according to claim 2, which is characterized in that: the powder of the cooked rhubarb is 60 to 80 meshes.
4. The rhubarb-containing traditional Chinese medicine toothpaste according to claim 3, which is characterized in that: the Chinese medicinal extract is an extract with a relative density of 1.2-1.31.
5. The rhubarb-containing traditional Chinese medicine toothpaste according to any one of claims 1 to 4, wherein: the auxiliary materials also comprise essence and preservative.
6. The preparation process of the traditional Chinese medicine toothpaste containing rhubarb is characterized by comprising the following steps:
mixing cooked radix et rhizoma Rhei powder and Chinese medicinal extractive solution to obtain Chinese medicinal components;
the preparation process of the cooked rhubarb powder comprises the following steps:
cutting radix et rhizoma Rhei into slices with thickness of 0.5-1.0cm, and drying at 55-60 deg.C;
drying slices per kilogram of rhubarb, and mixing with yellow wine: soaking the rheum officinale slices for 30 minutes by using yellow wine solution with the water mass part ratio of (0.3: 0.3-0.7);
steaming the soaked rhubarb slices for 4 hours to obtain clean rhubarb slices;
drying the clean rhubarb slices at 55-60 ℃ until the drying moisture is within 4 percent to obtain dry paste;
drying the dry paste to room temperature, crushing, and sieving by 60-80 meshes;
the preparation process of the traditional Chinese medicine extracting solution comprises the following steps:
mixing Coptidis rhizoma, cortex moutan, radix Angelicae sinensis, Coptidis rhizoma and cortex moutan at a weight ratio of 2:3:2, decocting with water, filtering, and concentrating to relative density of 1.2-1.3; adding ethanol into radix Angelicae sinensis to make ethanol content reach 70%, standing, and concentrating the supernatant to relative density of 1.2-1.3;
the toothpaste is obtained by uniformly mixing the traditional Chinese medicine components and auxiliary materials, wherein the traditional Chinese medicine components account for 0.5-2% of the toothpaste by weight, and the auxiliary materials at least comprise a thickening agent, a surfactant, a wetting agent, a foaming agent, an adhesive, a sweetening agent and deionized water.
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