CN111110759A

CN111110759A - Water-eliminating ointment for treating cancerous ascites and preparation method thereof

Info

Publication number: CN111110759A
Application number: CN201811298975.1A
Authority: CN
Inventors: 程志强; 宋兵虎; 张晨红; 吴军凯
Original assignee: Beijing Cancer Medical Research Institute Of China West Alliance General Partnership
Current assignee: Beijing Cancer Medical Research Institute Of China West Alliance General Partnership
Priority date: 2018-11-01
Filing date: 2018-11-01
Publication date: 2020-05-08

Abstract

The invention relates to a water-eliminating ointment for treating cancerous ascites and a preparation method thereof, and the water-eliminating ointment comprises the following components: 5-15 parts of euphorbia kansui, 5-15 parts of lilac daphne flower bud, 5-15 parts of euphorbia pekinensis, 5-15 parts of radix cynanchi wilfordii, 5-15 parts of cassia twig, 0.5-1.5 parts of borneol, 5-15 parts of bighead atractylodes rhizome, 5-15 parts of polyporus and 5-15 parts of radix stephaniae tetrandrae. The invention also provides a preparation method of the water-eliminating paste for cancerous ascites. The water-eliminating ointment of the invention is prepared by adopting the external application of the theory of dialectical treatment of the traditional Chinese medicine and taking 9 Chinese herbal medicines as raw materials, applies the traditional theory of the traditional Chinese medicine and adopts the method of treating both symptoms and root causes from the whole body of a patient, has unique curative effect on cancerous ascites, is applied externally, has the effective rate of more than 90 percent, is obviously superior to the clinically common western medicine treatment method, and simultaneously ensures that the life quality of the patient achieves the ideal effect.

Description

Water-eliminating ointment for treating cancerous ascites and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a water-removing paste for treating cancerous ascites and a preparation method thereof.

Background

The cancerous ascites is mostly caused by the metastasis of primary liver cancer, stomach cancer, intestinal cancer, ovarian cancer and the like, wherein the liver cancer is common, the cancerous ascites belongs to the categories of tumor mass, tympanites and the like in the traditional Chinese medicine according to the pathogenesis analysis of the traditional Chinese medicine, and is mostly acted on a human body for a long time by various causes, so that the deficiency of vital qi of the human body, qi-blood disharmony, pathogenic toxin accumulation, blood stasis and swelling toxin accumulation over time are caused to be not dispersed, the blood stasis and swelling toxin accumulation are caused in the abdomen to form tumor mass, the mass is gradually increased, the qi activity is blocked, the tunnel is blocked; spleen and kidney are deficient in function, and water-dampness is not transported and dissolved, so that the water-dampness stays in the body, and finally qi, blood and water are combined and accumulated in the abdomen to form tympanites. Therefore, the common treatment method for malignant ascites is to invigorate the spleen and tonify the kidney, promote diuresis and expel water, promote qi and blood circulation, remove blood stasis and dissipate stagnation, and the like.

Cancerous ascites is one of the common complications of middle and late stage cancer, and is also the main clinical symptom or sign of some patients, and serious and even life-threatening. At present, the conventional western medicine treatment means for treating the cancerous ascites is not limited to abdominal cavity puncture drainage, chemotherapy drug perfusion, diuresis dehydration, protein nutrition support and the like, but the conventional western medicine treatment means has the disadvantages of great benefit, namely huge toxic and side effects and tiny curative effect, cannot solve the actual pain of a patient, and reduces the life quality of the patient. And the cost of the medicine is high, and if the medicine is used for a long time, the medicine cannot be absorbed by ordinary income families.

Disclosure of Invention

In view of the above, the water-eliminating ointment is prepared by using 9 Chinese herbal medicines as raw materials, the traditional theory of traditional Chinese medicine is applied, the method of treating both symptoms and root causes is adopted from the whole patient, the water-eliminating ointment has unique curative effect on cancerous ascites and hydrothorax, the external application is verified by the treatment of more than 160 cases of cancerous ascites patients, the effective rate reaches over 90 percent, the effect is obvious, and the dependence and addiction of the patient to western medicines can not be caused.

In order to achieve the purpose, the invention adopts the following technical scheme:

a water-eliminating ointment for treating cancerous ascites comprises the following raw materials in parts by weight:

5-15 parts of euphorbia kansui, 5-15 parts of lilac daphne flower bud, 5-15 parts of euphorbia pekinensis, 5-15 parts of radix cynanchi wilfordii, 5-15 parts of cassia twig, 0.5-1.5 parts of borneol, 5-15 parts of bighead atractylodes rhizome, 5-15 parts of grifola, 5-15 parts of radix stephaniae tetrandrae

Preferably, the water-eliminating paste is prepared from the following raw materials in parts by weight:

10 parts of euphorbia kansui, 10 parts of lilac daphne flower bud, 10 parts of euphorbia pekinensis, 10 parts of eclipta alba, 10 parts of cassia twig, 1 part of borneol, 10 parts of bighead atractylodes rhizome, 10 parts of polyporus and 10 parts of radix stephaniae tetrandrae.

The invention also provides a method for preparing the water-eliminating paste, which comprises the following steps:

respectively cleaning the euphorbia kansui, the lilac daphne flower bud, the euphorbia pekinensis, the radix cynanchi, the cassia twig, the borneol, the bighead atractylodes rhizome, the grifola and the radix stephaniae tetrandrae in parts by weight, drying the cleaned products until the water content is 5-10%, and then mixing the products to obtain a mixed material;

under the aseptic and dustless conditions, the mixed materials are subjected to ultrasonic grinding by adopting an ultramicro grinding technology, so that the central particle size of the crude drug is below 10 mu m, and the cell wall breaking rate is over 94 percent, thereby obtaining mixed powder;

carrying out five-stage atomization by adopting a nano jet atomizer, embedding and drying the mixed powder into a plurality of nano microcapsule powder at normal temperature, wherein the particle size of each nano microcapsule powder is 20-80 nanometers;

adding 9-degree white vinegar into the microcapsule powder, adding water, decocting, and concocting into paste with water content of 20%;

and carrying out anaerobic fermentation on the paste at normal temperature for 2-4 months to obtain the water-eliminating paste.

Euphorbia kansui, a perennial herb, 25-40cm high. The alias is native to Honda, Ganze, Gansu, Ling Gao, Ganze, Baize, Binju, Ling Zi, and is a plant of Euphorbia of Euphorbiaceae, which is a specific plant of China. The record of the new edition of materia medica: gan sui can break down the symptoms and accumulation of hard mass like the spirit, relieve edema of face and eyes, dispel water retention in stomach, and induce diuresis. The water-damp-dispelling herbs can work slowly, the water-damp-dispelling herbs can work quickly, the slow ones are not slow, and the fast ones are not fast . However, gan sui should not be used lightly, and gan sui can not remove damp-heat and false-damp. Gan sui is indicated for the following diseases: edema, ascites, retained fluid, chest stagnation, epilepsy, cough and asthma, and constipation. Kansui root can stimulate the intestinal canal, increase the peristalsis of the intestine, produce the action of purgation and promote diuresis for human bodies.

Lilac daphne flower bud, another name: medicinal herb, common sage herb, Chinese azalea flower, headache flower, mugwort flower, headache skin, asbestos skin, puffed rice, mud autumn tree, radix Knoxiae, hollyhock, fish poison, Latin name: daphne genkwa sieb. et zucc. daphniaceae, Daphne deciduous shrub. Flos Genkwa parched with vinegar and Realgar, and ground into powder for oral administration for treating abdominal pain due to parasitic infestation; grinding flos Genkwa, mixing with lard, and applying externally for treating tinea capitis. Expel water and remove phlegm. It is indicated for phlegm-fluid retention, dyspnea and cough, edema, hypochondriac pain, abdominal and heart disease with distention and fullness, food poisoning, malaria, abscess and swelling. The book Jing: it is mainly manifested as cough, dyspnea, throat swelling, shortness of breath, malaria, hernia, carbuncle and swelling. The bibliography: phlegm and fluid in the chest, saliva and edema, five kinds of fluid in the skin, lumbago, lower cold and toxin and botulism. Treatise on herb Property: it is indicated for distending sensation in the heart and abdomen, removing water and qi, benefiting the five internal organs with cold phlegm and nasal discharge with glue. It is indicated for malignant sore, wind-damp arthralgia, all toxic wind, spasm and spasm of limbs, inability to walk, edema and distention. Compendium (compendium): it is indicated for hypochondriac pain due to water retention and phlegm differentiation.

Euphorbia pekinensis Rupr is a perennial herb of Euphorbiaceae, Euphorbia, up to 80 cm in height. Root circle cone shape. The stem stands upright, is short and velvety white, and branches at the upper part. The leaves are intergrown. Rectangular-round lanceolates to lanceolates. The cup-shaped inflorescence involucre is in a pot shape. The capsule has a trigone spherical shape and wart-like protrusion on surface. The seeds are oval and smooth. Growing on hillsides, roadside, barren slopes or in grasses. Breeding by seeds. The traditional Chinese medicine is used as a medicine for expelling water and relaxing bowels, reducing swelling and resolving masses, mainly treats edema and has the effect of restoring menstrual flow; can also be used for veterinary medicine; it should be used with cautions for toxicity. Bitter taste, cold nature and toxicity. Enter lung, spleen and kidney meridians. It can be used for treating edema, phlegm accumulation, carbuncle, furuncle, and constipation. It can also be used for phlegm and fluid accumulation, fullness and distention of chest and diaphragm, and dull pain in hypochondrium. It can be used for abscess, sores and scrofula due to phlegm-fire, and it is indicated for both oral and external application. The book Jing: "dominating twelve water, abdominal fullness and pain, accumulation, wind stroke, skin pain, vomiting and adverse rising of qi. "Addite records": mainly neck, axilla, carbuncle and swelling, headache, sweating and benefiting the large and small intestine. "(Rihuazi Ben Cao >): "Xie Du Yao", purge Tian xing Huang disease, warm malaria and break the abdominal mass. "modern practical Chinese medicine": it is indicated for ascites and general edema. Pleural effusion, and the like. "

Shang Lu, is a perennial herb. It is fond of warm, humid and shady environment, and is suitable for loose and fertile sandy loam, and the flowering period is 6-8 months. It is suitable for planting in residential area, slope area and wet and shady area, and is suitable for seeding or plant division propagation. The efficacy is mainly as follows: eliminating phlegm, relieving asthma, relieving cough, resisting bacteria, resisting inflammation and promoting urination. It is indicated for edema, fullness and distention, beriberi, sore throat, abscess, swelling and sore. Rihuazi Bencao: unblocking large and small intestines, purging poison, weighing fetus, applying malignant boil. "Shen nong Ben Cao Jing: edema, hernia and arthralgia. Remove abscess and swelling by hot compress.

Cassia twig, another name: willow (scientific name: Cinnamomum cassia Presl) is a dried twig of Cinnamomum cassia Presl of Lauraceae. Harvesting in spring and summer, removing leaves, drying in the sun or slicing and drying in the sun, wherein the product is in a long cylindrical shape with multiple branches, the length of the product is 30-75 cm, and the diameter of the thick end of the product is 0.3-1 cm. The surface is reddish brown to brown, and has longitudinal ridge, fine wrinkle, leaf mark, branch mark, bud mark and skin hole point. Hard and brittle and easy to break. The thickness of the slice is 2-4 mm, the skin part of the cross section is reddish brown, the wood part is yellowish white to light yellowish brown, and the medulla part is slightly square. Has special fragrance, sweet and slightly pungent taste and stronger skin taste. The efficacy is as follows: induce sweating to expel pathogenic factors from the muscles, warm and dredge meridians, strengthen yang and transform qi. For phlegm-fluid retention syndrome due to spleen yang deficiency, it is often combined with Fu Ling Gui Zhu gan Tang (golden Kui Yao L ü e), which is indicated for edema and dysuria of bladder water-retention syndrome, and with Fu Ling, Zhu Ling and ze Xie, such as Wu Ling san (Shang Han Lun). The cassia twig decoction has the functions of cooling and relieving fever; the decoction and the alcohol soaking also have the inhibiting effect on staphylococcus aureus, typhoid bacillus, influenza virus and the like; the volatile oil can stimulate sweat gland, dilate blood vessel, promote urination, strengthen heart, relieve cough, and eliminate phlegm; the cinnamaldehyde has analgesic, tranquilizing, and anticonvulsive effects.

Borneolum, named as Borneolum, pericarpium Citri Tangerinae, folium Artemisiae Argyi, Borneolum Syntheticum, Serissa, Borneolum Syntheticum, and Borneolum Syntheticum, is prepared from stems and leaves of blumea balsamifera of Compositae or branches and leaves of Cinnamomum camphora of Lauraceae by steam distillation and recrystallization. Also can be obtained by a series of chemical processes using turpentine. It can be used for treating block pattern of coma, conjunctival congestion with swelling and pain, pharyngitis, aphtha, sore and ulcer with swelling and pain, and unhealed ulcer. Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): it is contraindicated for patients with apoplexy due to qi and blood deficiency, but without exogenous pathogenic wind; the infantile vomiting and diarrhea with convulsion is slow spleen wind, the acute convulsion is due to excess heat, and the slow convulsion is due to deficiency-cold; herbs should not be used for dim eyes due to deficiency of liver and kidney. "newly revised materia Medica: "governing heart and abdomen pathogenic qi, wind-damp accumulation, deafness, improving vision, removing blood-shot eyes and nebula. "compendium of materia Medica": treating pharyngitis, encephalodynia, nasal , toothache, typhoid fever, tongue prolapse, and infantile pox. Unblock orifices and dissipate stagnated fire. "[ treaty in meditation": borneol can dispel stagnated fire, can induce bone heat, and can cure fright epilepsy, phlegm stagnation, pharyngitis, tongue distension, toothache, deafness, nasal obstruction, conjunctival congestion, nebula, acne toxin invagination, disinsection, hemorrhoid, hasten growth, and promote granulation and alleviate pain. It is always released and exhausted, and is also the cause of yin-cold. Borneol is colorless transparent or white semitransparent flaky crisp crystal; fragrant smell, pungent and cool taste. Borneol is easy to be absorbed by mucosa and subcutaneous tissue, and is combined with glucuronic acid in vivo and then discharged out of body.

Atractylodis rhizoma (zh u.), the scientific name Atractylodes macrocepha. Floating thistle herb, Yuzhu, Dong Bai Zhu, Thunberg, Yang Fu, Wu Zhu, Ye Zhu, cang Zhu, belonging to Compositae and Atractylodes perennial herb. Pleased in cool climate, has multiple medicinal functions by using rhizome as medicine. Mainly distributed in mountainous wetlands such as Sichuan, Yunnan, Guizhou and the like. The rhizoma atractylodis macrocephalae has the effects of strengthening spleen and tonifying qi, eliminating dampness and promoting diuresis, arresting sweating and preventing miscarriage, and is used for treating spleen deficiency and anorexia, abdominal distension and diarrhea, phlegm and fluid retention and dizziness and palpitation, edema, spontaneous perspiration and threatened abortion. Record of "medical enlightenment": the traditional Chinese medicine composition has the effects of removing dampness and benefiting dryness, regulating the middle warmer and replenishing qi, warming the middle warmer, removing dampness in the spleen and stomach, removing stomach heat, strengthening the spleen and stomach, taking food and preventing miscarriage. "Shen nong Ben Cao Jing: and (4) performing the operation. Bitter and warm taste. Mainly wind-cold-dampness arthralgia, spasm and jaundice, hidroschesis, heat removal and digestion promotion, and is used as a fried bait. Can be taken for a long time to reduce weight and prolong life without hunger. Radix seu herba Cirsii Japonici, and radix Valerianae. Changsha Yao Jie (Changsha Yao Jie solution): sweet and slightly bitter in flavor, entering foot yang brightness stomach and foot taiyin spleen meridian. Tonify middle energizer and dry dampness, quench thirst and promote fluid production, benefit spleen essence, nourish stomach qi, descend turbid yin to eat and drink, relieve vomiting, ascend clear yang to digest food, and can purge and benefit. The functional indications are as follows: invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion. Tu Bai Zhu strengthens spleen, harmonizes stomach and prevents abortion. Can be used for treating spleen deficiency, anorexia, diarrhea, loose stool, and threatened abortion.

Polyporus umbellatus, medicinal fungus of Grifola of Polyporaceae of Aphyllophorales. The fruiting body is large or very large, the flesh has stem, many branches, and round white to light brown pileus growing at the end, and the diameter of one cluster can reach 35 cm. The pileus is circular, the middle part is concave and is near funnel shape, the edge is inward-rolled, and the pileus is covered by dark thin scale with width of 1-4 cm. The mushroom flesh is white, the pore surface is white, and the mushroom flesh is grass yellow after being dried. The orifices are circular or broken and are irregularly toothed, and the number of the orifices is 2-4 per millimeter on average. The spore is colorless, smooth, and cylindrical, and has a round end and a tip with a diameter of 7-10 μm × 3-4.2 μm. The economic value is as follows: the fruiting body is edible when young and tender, and has good taste. The underground sclerotium is black and various in shape, is a famous traditional Chinese medicine, and has the effects of promoting urination and treating edema. Contains Polyporus polysaccharide (glucan), and is used for anticancer. The alias of the medicinal materials: polyporus umbellatus, hogwort, Oletum Sublicus, pig ligularia, Sparassis Crassipes, Siegesbeckiae herba, rhizoma anemones Flaccidae, fructus Aristolochiae Gagnep, Polyporus umbellatus, Poria, and Oletum Trogopterori. The efficacy is as follows: induce diuresis and drain dampness. It is indicated for dysuria, edema, diarrhea, stranguria with turbid urine and leukorrhagia.

Menispermaceae, the name of traditional Chinese medicine. Is dried root of Stephania tetrandra S.Moore of Menispermaceae. The efficacy is as follows: dispel wind, alleviate pain, induce diuresis to alleviate edema. Plucked in autumn, cleaned, removed of coarse peel, sun-dried to half dry, cut into segments, and cut into large pieces, and dried. Used for treating edema, ascites, dysuria and beriberi: being bitter and cold with descending and diuresis, it can clear heat and induce diuresis, so it is good at moving downward to purge damp-heat in lower energizer bladder, especially suitable for edema of lower limbs and dysuria. It is usually combined with Huang Qi, Bai Zhu and gan Cao for treating wind-water floating pulse, heavy body sweating and aversion to wind, such as Fang Ji Huang Tang (jin Kui Yao L ü e).

The invention has the beneficial effects that:

(1) the water-eliminating paste is prepared from 9 Chinese herbal medicines, and is prepared by using the theory of dialectical treatment of traditional Chinese medicine, starting from regulating qi and activating blood, and assisting in the drug effects of purging water and expelling fluid, supporting yang and regulating qi, and eliminating dampness and inducing diuresis, so as to finally achieve the purpose of treating cancer pain, wherein the euphorbia kansui is prepared by purging water and expelling fluid, and reducing swelling and dissipating stagnation; flos Genkwa for purging water and removing retention, removing toxic substance and killing parasite; euphorbia root, radix Euphorbiae Humifusae, for purging retained fluid and promoting urination and defecation; shanglu, expelling water and dispersing swelling, promoting urination and defecation, detoxifying and dissipating stagnation; ramulus Cinnamomi for relieving exterior syndrome, expelling pathogenic factors from muscles, warming channels, promoting circulation of qi, supporting yang, and regulating qi; borneol: inducing resuscitation, refreshing mind, clearing heat and relieving pain; atractylodis rhizoma for invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis, and arresting sweating; and (3) polyporus umbellatus: promoting urination and excreting dampness; fangji, inducing diuresis to alleviate edema, dispelling wind-evil and relieving pain. The above medicines are compatible with each other to achieve the effect of eliminating water.

(2) The invention adopts 9 Chinese herbal medicines to prepare external paste according to the formula, and the external paste is externally applied to strengthen the spleen and tonify the kidney, promote diuresis and expel water, promote qi and blood circulation, remove blood stasis and dissipate stagnation so as to achieve the purpose of treating cancerous ascites. The invention is suitable for various cancer pains, such as liver ascites, and the like, and in the clinical application process, more than 170 cancer ascites patients are treated, wherein the effective rate of treatment is more than 90 percent, and the method is obviously superior to the clinically common western medicine treatment method.

(3) The invention grinds each raw material into powder, and adds water to carry out anaerobic fermentation for 2-4 months, utilizes a microecology and bionics method, simulates the intestinal environment of a human body and the digestive decomposition process of traditional Chinese medicine components in the human body in vitro by a biological grafting mode, carries out biological transformation on the extracted traditional Chinese medicine effective components, converts macromolecular substances of the traditional Chinese medicine into small molecular components which can be directly absorbed by the intestinal tract of the human body by microorganisms, 9 kinds of Chinese herbal medicines which are pre-digested and transformed not only completely remove the harmful toxicity of each medicine, but also the formed paste has quantitative curative effect and can be quickly absorbed by the human body, the drug effect is improved by 8-24 times compared with the traditional Chinese medicine, wherein the invention adopts the embedding conditions of ultrasonic pulverization and five-stage atomization, can completely extract the effective components in the medicinal materials, thereby solving the problems of slow treatment effect and inaccurate treatment effect of the medicine prepared by adopting the same raw materials.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

Example 1

5 parts of euphorbia kansui, 5 parts of lilac daphne flower bud, 5 parts of euphorbia pekinensis, 5 parts of radix cynanchi wilfordii, 5 parts of cassia twig, 0.5 part of borneol, 5 parts of bighead atractylodes rhizome, 5 parts of polyporus umbellatus and 5 parts of radix stephaniae tetrandrae.

The preparation method of the water eliminating paste comprises the following steps:

1. mixing materials: respectively cleaning the euphorbia kansui, the lilac daphne flower bud, the euphorbia pekinensis, the radix cynanchi, the cassia twig, the borneol, the bighead atractylodes rhizome, the grifola and the radix stephaniae tetrandrae in parts by weight, drying the cleaned products until the water content is 5-7%, and then mixing the products to obtain a mixed material; wherein the particle fineness of the mixed powder is not less than 200 meshes.

2. Crushing: under the aseptic and dustless conditions, the mixed materials are subjected to ultrasonic crushing by adopting an ultramicro crushing technology, so that the central particle size of the crude drug is about 6 mu m, the cell wall breaking rate reaches more than 95%, the active ingredients in the crude drug are directly exposed, and the dissolution and the effect taking of the components of the crude drug are more rapid and complete, so that the mixed powder is obtained;

3. embedding: the nanometer jet atomizer is adopted for five-stage atomization, the mixed powder is embedded and dried into a plurality of nanometer microcapsule powder at normal temperature, and the particle size of each nanometer microcapsule powder is 20-40 nanometers, so that the active ingredients of the medicine can be prevented from volatilizing and can be directly absorbed by the skin of a human body easily, the active substances can play a role, the bioavailability of the medicine is improved, and the medicine effect is improved; the process of five-stage atomization by adopting the nano jet atomizer comprises the following steps: the concentrated solution is atomized by five stages at normal temperature, namely the concentrated solution is brought into the jet flow spray cavity by high-pressure airflow through the liquid inlet pipe, the spraying speed of each stage is more than 800 m/s, and finally the concentrated solution is sprayed out from the jet hole of the jet flow spray nozzle.

4. Paste preparation: when in use, 9-degree white vinegar is added into the microcapsule powder, water is properly added according to the requirement for decoction, and the mixture is prepared into paste with the water content of 20 percent; wherein the modulating comprises: heating to boil with strong fire, decocting with small fire at 50-60 deg.C, and concentrating.

5. Preparing paste: and carrying out anaerobic fermentation on the paste at normal temperature for 2 months to obtain blocky water-eliminating paste.

Example 2

1. mixing materials: respectively cleaning the euphorbia kansui, the lilac daphne flower bud, the euphorbia pekinensis, the radix cynanchi, the cassia twig, the borneol, the bighead atractylodes rhizome, the grifola and the radix stephaniae tetrandrae in parts by weight, drying the cleaned products until the water content is 6-8%, and then mixing the products to obtain a mixed material;

2. crushing: under the aseptic and dustless conditions, the mixed materials are subjected to ultrasonic crushing by adopting an ultramicro crushing technology, so that the central particle size of the crude drug is about 5 mu m, the cell wall breaking rate reaches more than 95%, the active ingredients in the crude drug are directly exposed, and the dissolution and the effect taking of the components of the crude drug are more rapid and complete, so that the mixed powder is obtained;

3. embedding: the nanometer jet atomizer is adopted for five-stage atomization, the mixed powder is embedded and dried into a plurality of nanometer microcapsule powder at normal temperature, and the particle size of each nanometer microcapsule powder is 40-60 nanometers, so that the active ingredients of the medicine can be prevented from volatilizing and can be directly absorbed by the skin of a human body easily, the active substances can play a role, the bioavailability of the medicine is improved, and the medicine effect is improved;

5. Preparing paste: and carrying out anaerobic fermentation on the paste at normal temperature for 3 months to obtain blocky water-eliminating paste.

Example 3

15 parts of euphorbia kansui, 15 parts of lilac daphne flower bud, 15 parts of euphorbia pekinensis, 15 parts of eclipta alba, 15 parts of cassia twig, 1.5 parts of borneol, 15 parts of bighead atractylodes rhizome, 15 parts of polyporus and 15 parts of radix stephaniae tetrandrae.

1. mixing materials: respectively cleaning the euphorbia kansui, the lilac daphne flower bud, the euphorbia pekinensis, the radix cynanchi, the cassia twig, the borneol, the bighead atractylodes rhizome, the grifola and the radix stephaniae tetrandrae in parts by weight, drying the cleaned products until the water content is 7-9%, and then mixing the products to obtain a mixed material;

3. embedding: the nanometer jet atomizer is adopted for five-stage atomization, the mixed powder is embedded and dried into a plurality of nanometer microcapsule powder at normal temperature, and the particle size of each nanometer microcapsule powder is 30-50 nanometers, so that the active ingredients of the medicine can be prevented from volatilizing and can be directly absorbed by the skin of a human body easily, the active substances can play a role, the bioavailability of the medicine is improved, and the medicine effect is improved;

The following description will further illustrate the beneficial effects of the topical medicament of the present invention through clinical case statistics using the water-eliminating ointment obtained in example 2.

The clinical cases of the disease comprise 170 cases, wherein the age of the disease is 50-75 years, the average age is 60 years, and the cases comprise liver cancer, gastric cancer, intestinal cancer and ovarian cancer.

1. Cancer pain observation

(1) Assessment of pain

No pain 0, severe pain 100;

(2) intensity of pain

0-no pain; 1-mild discomfort; 2-discomfort; 3-difficulty in handling; 4-feared pain; 5-extreme pain;

2. criteria for therapeutic effect

The effect is shown: the pain integral value after treatment is reduced by more than or equal to 70 percent compared with the integral value before treatment.

The method has the following advantages: the pain integral value after treatment is reduced by more than or equal to 30 percent and less than 70 percent compared with the integral value before treatment.

And (4) invalidation: the post-treatment pain integrated value was < 30% lower than the pre-treatment integrated value.

Note: calculation formula (nimodipine method): [ (integration before treatment-integration after treatment) ÷ integration before treatment ] × 100%.

3. Therapeutic results

The water-removing ointment treats 170 cancer pains, wherein 90 cases of obvious effects, 68 cases of effective effects and 12 cases of ineffective effects have a total effective rate of 92.94 percent, and the treated effective patients are all called that the water-removing ointment can relieve pains within 30 minutes of taking the water-removing ointment, dependence and addiction of other commonly taken analgesics such as non-opioid analgesics or opioid analgesics are not generated, and the pain effect is obviously reduced after the water-removing ointment is continuously used for 10-20 days.

Example of the medical record 1

Zheng, male, 68 years old, retired worker. The initial diagnosis in 5 months and 20 days in 2013 mainly comprises the following complaints: the liver was found to be blocked for more than 1 month. The patient feels the feeling of abdominal fullness before 1 month, the liver area is dull and painful, and the body weight is gradually reduced with asthenia. The history of hepatitis is 13 years. Prompting abdominal ultrasound and CT examination: nodules of 5cm multiplied by 5cm and 3cm multiplied by 3cm are seen in the right liver lobe, moderate cirrhosis, and positive detection of alpha-fetoprotein. Then, the tissue biopsy is carried out under the ultrasonic guidance of a hospital in the transportation city center, and the primary liver cancer is confirmed by pathological section examination. Patients refused surgery and were treated conservatively. The symptoms are sallow complexion, paroxysmal dull pain in the liver area, stuffiness and hardness in the epigastrium, abdominal distension and no appetite, listlessness and dry stool. A deep-red tongue with no coating and a thready, wiry and rapid pulse. The traditional Chinese medicine diagnosis is as follows: the pattern of liver fullness is due to qi stagnation and blood stasis. The medicine is administered for 2-4 hours per day on average, pain is relieved after continuous treatment for 15 days, and the pain can be tolerated and appetite is improved after the repeated diagnosis after 1 month.

Example of the medical record 2

Jinzhi, woman, age 58, first visit 6/month/4/2014. The main complaints are: the abdominal pain is more than 3 months. The patient had abdominal pain and weight loss 3 months ago. The local hospital has performed gastrointestinal barium transudation, which prompts the patient to ascend colon cancer, refuses surgery and chemotherapy, and seeks traditional Chinese medicine conservative treatment. The symptoms include persistent abdominal pain, painful face, listlessness, anorexia, poor sleep, chest distress, short breath, loose stool, purulent blood, aversion to cold, cold limbs, pale red tongue, white greasy coating, deep, thready and intermittent pulse. Physical examination: the whole abdomen is flat and soft, the right abdomen is tenderness, the rebound pain is negative, and the percussion pain of the kidney and liver regions is negative. Traditional Chinese medicine diagnosis: abdominal pain (spleen and kidney deficiency, blood stasis obstructing collaterals). After the medicine is continuously used for 12 days, the average time is 2 hours per day, the pain is relieved, the abdominal pain disappears after the 3-week consultation, and the body weight is increased compared with the former.

Cancer pain is a particular type of pain, a common symptom in patients with mid-to-late stage cancer, and the cause is directly related to malignancy. From the clinical point of view, the pathogenesis of cancer pain is characterized by deficiency and excess mixed, the deficiency is caused by healthy qi damage, the excess is qi stagnation, blood stasis and the like, and the treatment generally aims at strengthening healthy qi and eliminating evil to dredge and relieve pain. The traditional Chinese medicine has definite clinical curative effect on treating the cancerous ascites, and plays a great role in relieving pain in a plurality of middle and late cancer patients. The traditional Chinese medicine has slow and lasting analgesic effect, and has the advantages of no addiction, drug resistance, little toxic and side effect and the like. Through a large number of clinical verifications, the invention can improve the life quality and the immunologic function of patients, has high safety and definite curative effect, and is worthy of popularization. Has obvious advantages in clinical practice for treating the cancerous ascites, and has wide prospects in future development and application.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. The water-eliminating ointment for treating cancerous ascites is characterized by comprising the following raw materials in parts by weight:

5-15 parts of euphorbia kansui, 5-15 parts of lilac daphne flower bud, 5-15 parts of euphorbia pekinensis, 5-15 parts of radix cynanchi wilfordii, 5-15 parts of cassia twig, 0.5-1.5 parts of borneol, 5-15 parts of bighead atractylodes rhizome, 5-15 parts of grifola and 5-15 parts of radix stephaniae tetrandrae.

2. The water eliminating paste as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight:

3. A method of preparing a paste according to any one of claims 1 to 2, comprising the steps of:

(1) respectively cleaning the euphorbia kansui, the lilac daphne flower bud, the euphorbia pekinensis, the radix cynanchi, the cassia twig, the borneol, the bighead atractylodes rhizome, the grifola and the radix stephaniae tetrandrae in parts by weight, drying the cleaned products until the water content is 5-10%, and then mixing the products to obtain a mixed material;

(2) under the aseptic and dustless conditions, the mixed materials are subjected to ultrasonic grinding by adopting an ultramicro grinding technology, so that the central particle size of the crude drug is below 10 mu m, and the cell wall breaking rate is over 94 percent, thereby obtaining mixed powder;

(3) carrying out five-stage atomization by adopting a nano jet atomizer, embedding and drying the mixed powder into a plurality of nano microcapsule powder at normal temperature, wherein the particle size of each nano microcapsule powder is 20-80 nanometers;

(4) adding 9 degree white vinegar into the microcapsule powder, adding water, decocting, and concocting into paste with water content of 20%.

4. The method according to claim 3, wherein the paste is anaerobically fermented at room temperature for 2-4 months after the paste is prepared, to prepare a water-absorbing paste in the form of a block.

5. The production method according to claim 3, wherein the particle fineness of the mixed powder in the step (2) is not less than 200 mesh.

6. The preparation method according to claim 3, wherein the decocting in the step (4) is carried out by heating to boiling with strong fire and then decocting with slow fire at 50-60 ℃.

7. The method according to claim 3, wherein in the step (2), the particle diameter of the crude drug at the center is 5 to 6 μm.