CN111053887A - Composition for resisting propionibacterium acnes and regulating skin microecology and application - Google Patents
Composition for resisting propionibacterium acnes and regulating skin microecology and application Download PDFInfo
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Abstract
The invention belongs to the technical field of medical biology, and discloses a composition for resisting propionibacterium acnes and regulating skin microecology; the paint comprises the following components in parts by weight: 0.5-3 parts of nisin, 0.1-2 parts of polylysine, 0.1-2 parts of cordycepin, 0.1-1 part of lysozyme, 10-50 parts of water and 0.5-4 parts of pH regulator. The composition has remarkable antagonistic effect on the growth of Propionibacterium acnes and Staphylococcus aureus, and can weaken the film-forming growth of Propionibacterium acnes, thereby weakening the skin invasiveness, intervening the occurrence and development of acne, and further achieving the effect of preventing and treating acne; the composition helps to restore skin microecological balance by regulating microbial flora on skin surface, and main components of the composition can be degraded into amino acids, and can provide partial nutrition matrix for skin repair. The composition can be added into skin microecological preparation, anti-acne preparation or acne-removing preparation.
Description
Technical Field
The invention belongs to the technical field of medical biology, and particularly relates to a composition for resisting propionibacterium acnes and regulating skin microecology and application thereof.
Background
The skin is the largest organ of the human body, part of microorganisms inhabited on the skin provide ecological protection for the skin, and skin diseases such as the overgrowth of propionibacterium acnes can be caused when the skin flora is unbalanced, so that the skin is acnes. Propionibacterium acnes is a multi-drug resistant bacterium, the growth of which is easy to generate a bacterial film, is one of skin invasive factors, and is easier to grow anaerobically and resist the action of antibiotics. In general, drugs such as antibiotics and hormones are mostly adopted for treating acne, but the effect is not good.
The skin is an ecosystem consisting of niches (micro-ecosystems) in different locations. About one billion bacteria are symbiotic on the surface of the skin per square centimeter, forming a microecological "shield". Most skin infectious diseases can use a microecological method to adjust normal flora of the skin, promote microecological balance, improve microenvironment (ecological niche), adjust skin barriers, consolidate the planting force of the normal flora, balance the flora number and conform to the microecological law, thereby achieving the purposes of treating and preventing diseases. In recent years the skin micro-ecology has become a hot spot in the skin field, and a new consensus has also been formed: the skin barrier, the skin microecology and the skin immunity jointly form a first defense system of an organism, resist the stimulation of various external factors and maintain the normal functions of the skin and the organism. The prior art also lacks drugs that effectively regulate the skin's micro-ecology.
Therefore, it is desirable to provide a composition for regulating skin micro-ecology against propionibacterium acnes with good effects.
Disclosure of Invention
In view of the deficiencies of the prior art, the present invention provides a composition for combating propionibacterium acnes and for regulating the skin micro-ecology. The composition of the invention is prepared from nisin, polylysine, cordycepin and lysozyme according to a certain proportion under certain process conditions, has self-antiseptic property, has the function of killing or inhibiting the growth of various bacteria, particularly has obvious antagonistic action on the growth of propionibacterium acnes and staphylococcus aureus, can weaken the film-forming growth of propionibacterium acnes and weaken the skin invasiveness thereof, and thus achieves the effect of preventing and treating acne. Meanwhile, the main components of the composition are mostly degradable into amino acids, so that partial nutrient substrates can be provided for skin repair, and in addition, the composition has a good effect on regulating the skin microecology.
In addition, the invention also provides a preparation method of the composition for resisting the propionibacterium acnes and regulating the skin micro-ecology.
The composition for resisting propionibacterium acnes and regulating skin microecology comprises the following components in parts by weight:
preferably, the molecular weight of the polylysine is 3600-4300.
Preferably, the water is deionized water subjected to sterilization treatment.
Preferably, the cordycepin is derived from an extract of Cordyceps sinensis.
The molecular weight of the polylysine is between 3600-4300, the antibacterial activity of the polylysine is the best, and when the molecular weight is lower than 1300, the polylysine has no antibacterial activity.
Preferably, the pH adjusting agent is citric acid.
Preferably, the pH of the composition is 4 to 6.5; further preferably, the pH of the composition is 5.2 to 5.8.
A method for preparing a composition for resisting propionibacterium acnes and regulating skin microecology comprises the following steps:
(1) weighing the components according to the formula ratio, adding a pH regulator into water, and regulating the pH to 4.0-6.0 to prepare a mixture for later use;
(2) and (2) adding nisin, polylysine, cordycepin and lysozyme into the mixture prepared in the step (1), stirring and dissolving until the prepared mixture is transparent, thus preparing the composition for resisting propionibacterium acnes and regulating skin microecology.
Preferably, the pH is adjusted to 5.2-5.8 in step (1).
A preparation comprises the composition, and the composition accounts for 0.1-20% of the preparation in percentage by mass.
Preferably, the preparation is at least one of a skin micro-ecological regulating preparation, an anti-acne preparation or an anti-acne preparation.
A composition for resisting skin infection contains the composition provided by the invention.
A disinfectant comprising the composition of the present invention. The disinfectant can be used for disinfecting medical instruments.
The composition has the function of antagonizing the growth of common pathogenic bacteria of the skin, such as staphylococcus aureus, propionibacterium acnes and other bacteria, so as to regulate the microecology of the skin. The composition comprises components degradable into amino acids, such as nisin, polylysine and lysozyme, and can provide topical nutrition to skin. Meanwhile, the composition also endows the preparation with the preservative effect, so that the preparation does not need to be additionally added with other traditional preservatives.
The composition comprises the components of nisin, polylysine, cordycepin, lysozyme and the like, has the effect of inhibiting the growth of various bacteria, particularly has obvious inhibition on the growth of multi-drug resistant propionibacterium acnes, and can weaken the bacterial membrane generation of the propionibacterium acnes and weaken the invasiveness of the propionibacterium acnes on the skin. The composition contains degradable amino acids, is beneficial to topical nutrition of skin, and can be applied to normal skin, skin injury, skin infection, and skin acne, so as to be beneficial to normal ecological stability and recovery of skin.
The compositions of the present invention provide a means for interfering with bacterial infection or contamination other than antibiotics, such as significantly antagonizing the growth of Staphylococcus aureus, Propionibacterium acnes, Escherichia coli, and in particular, attenuating the bacterial membrane formed by the growth of Propionibacterium acnes, thereby reducing its invasiveness. The composition has the function of antagonizing the growth of propionibacterium acnes, and can be applied to the preparation of clinical skin microecological preparations, anti-contusion sore preparations and anti-acne preparations.
Compared with the prior art, the invention has the following beneficial effects:
(1) the composition disclosed by the invention is added into a preparation and used on the skin, has an antibacterial effect on gram-positive bacteria, gram-negative bacteria, staphylococcus aureus, heat-resistant coliform group, pseudomonas aeruginosa, white streptococcus, aspergillus niger, saccharomycetes and propionibacterium acnes, helps to restore the microecological balance of the skin by regulating microbial flora on the surface of the skin, and can be degraded into amino acids as main components to provide a partial nutrient substrate for skin repair.
(2) The composition has obvious antagonism on the growth of propionibacterium acnes and staphylococcus aureus, and can weaken the film-forming growth of propionibacterium acnes, thereby weakening the skin invasiveness, intervening the occurrence and development of acne, and further achieving the effect of preventing and treating the acne.
(3) Methods of interfering with bacterial infection or contamination other than antibiotics are provided.
Detailed Description
In order to illustrate the technical solution of the present invention, the following examples are given for illustration. It should be noted that the following examples are not intended to limit the scope of the claimed invention.
Example 1
The composition for resisting propionibacterium acnes and regulating skin microecology comprises the following components in parts by weight:
the molecular weight of the polylysine is 3900-4000.
The cordycepin is derived from Cordyceps sinensis extract.
The pH regulator is citric acid.
A method for preparing a composition for resisting propionibacterium acnes and regulating skin microecology comprises the following steps:
(1) weighing the components according to the formula ratio, adding a pH regulator into water, and regulating the pH to 5.2 to prepare a mixture for later use;
(2) and (2) adding nisin, polylysine, cordycepin and lysozyme into the mixture prepared in the step (1), stirring and dissolving until the prepared mixture is transparent, thus preparing the composition for resisting propionibacterium acnes and regulating skin microecology.
Example 2
The composition for resisting propionibacterium acnes and regulating skin microecology comprises the following components in parts by weight:
the molecular weight of the polylysine is 4000-4100.
The water is deionized water subjected to sterilization treatment.
The cordycepin is derived from Cordyceps sinensis extract.
The pH regulator is citric acid.
A method for preparing a composition for resisting propionibacterium acnes and regulating skin microecology comprises the following steps:
(1) weighing the components according to the formula ratio, adding a pH regulator into water, and regulating the pH to 5.8 to prepare a mixture for later use;
(2) and (2) adding nisin, polylysine, cordycepin and lysozyme into the mixture prepared in the step (1), stirring and dissolving until the prepared mixture is transparent, thus preparing the composition for resisting propionibacterium acnes and regulating skin microecology.
Example 3
The composition for resisting propionibacterium acnes and regulating skin microecology comprises the following components in parts by weight:
the molecular weight of polylysine is 3600-3800.
The water is deionized water after sterilization treatment.
Cordycepin is derived from Cordyceps extract.
The pH regulator is citric acid.
A method for preparing a composition for resisting propionibacterium acnes and regulating skin microecology comprises the following steps:
(1) weighing the components according to the formula ratio, adding a pH regulator into water, and regulating the pH to 5.0-5.5 to prepare a mixture for later use;
(2) and (2) adding nisin, polylysine, cordycepin and lysozyme into the mixture prepared in the step (1), stirring and dissolving until the prepared mixture is transparent, thus preparing the composition for resisting propionibacterium acnes and regulating skin microecology.
Product effectiveness testing
Tables 1-3 below are laboratory data tested for Propionibacterium acnes, Staphylococcus aureus, and Escherichia coli antagonism under conventional laboratory conditions using the compositions prepared in examples 1 and 2.
TABLE 1 Effect of the composition prepared in example 1 on Propionibacterium acnes growth (colony count, cfu/mL)
| Incubation time | Sterilizing deionized water | 1/10 | 1/100 | 1/1000 |
| 0h | 8.0×107 | 8.0×107 | 8.0×107 | 8.0×107 |
| 24h | 3.4×108 | 9.0×102 | 1.2×105 | 3.6×108 |
| 48h | 7.6×108 | 9.9×103 | 7.5×104 | 1.2×109 |
As can be seen from the results in Table 1, the prepared composition of example 1 has a significant inhibitory effect on the growth of Propionibacterium acnes, and is dose-effect dependent and can even impair the bacterial membranous production of Propionibacterium acnes. (1/10, 1/100, 1/1000 and 1/10000 in Table 1-2 indicate that the compositions were diluted with deionized water by 10 times, 100 times, 1000 times and 10000 times, respectively)
TABLE 2 Effect of the composition prepared in example 2 on Propionibacterium acnes growth antagonism (colony count, cfu/mL)
As can be seen from the results in Table 2, the prepared composition of example 2 has a significant inhibitory effect on the growth of Propionibacterium acnes, and is dose-effect dependent and can even impair the bacterial membranous production of Propionibacterium acnes.
TABLE 3 antagonism of bacterial growth (spot test) of the compositions prepared in examples 1 and 2
Note: the concentration of bacteria used was approximately 105-106 cfu/mL.
Sy269 is staphylococcus aureus, 6919 is propionibacterium acnes, 47015 is escherichia coli, all of which are common strains in laboratories.
2.+ is positive, with + stronger, with-negative.
As can be seen from the results in Table 3, the compositions prepared in examples 1 and 2 have strong antagonistic inhibitory effects against Propionibacterium acnes, Staphylococcus aureus, and Escherichia coli.
Application example 1: example 2 Regulation of skin Microecology by the compositions prepared
2 patients with facial acne were selected, 1 in each of men and women, with a course of 1-3 years, and after cleansing the face every morning and evening, an aqueous solution containing 10% of the composition prepared in example 2 was used for 4 weeks continuously. In addition, 1 case of each of the healthy control group 2, male and female was set.
Applying a cotton swab in a sterilized phosphate buffer solution (PBS, the same below) to an acne skin lesion area (about 4cm multiplied by 4cm) on a cleaning face for more than 4 hours from inside to outside with slight force, immediately shearing off a cotton swab head by using a sterile scissors after collection, placing the cotton swab head into a test tube containing 5mL of sterile conveying liquid, screwing down the cotton swab head by using a screw cap, taking the cotton swab head back to a laboratory, and collecting the treated acne patient in the skin lesion improvement area by the method; healthy adult specimens were collected at the center of the forehead as above. The staphylococcus epidermidis and propionibacterium acnes which are more than the total number of normal skin colonies on the skin of an acne patient are taken as representative flora, the flora is counted, and the facial pH value of a tested person is tested (the pH value of the normal skin is 5.0-7.0), and the experimental results are shown in the following table:
table 4: counting result and pH value of viable bacteria of facial skin flora
| Staphylococcus epidermidis | Propionibacterium acnes | pH value | |
| Before treatment | 4.36 | 4.96 | 4.84 |
| After treatment | 3.22 | 3.52 | 5.55 |
| Healthy controls | 3.38 | 3.69 | 5.60 |
Note: the number in the table is the viable bacteria technique per square centimeter of skin, namely CFU/ML/cm2And is indicated by log 10.
Table 4 shows the viable count results and pH values of facial flora, and after 2 weeks using the aqueous solution containing 10% of the composition prepared in example 2, the population numbers of staphylococcus epidermidis and propionibacterium acnes on the face of acne patients were significantly decreased and restored to normal levels, and the facial pH values tended to normal levels, which indicates that the composition prepared in example 2 of the present invention has the effect of regulating skin micro-ecology.
The subject has no skin irritation and no local and systemic adverse reaction.
Claims (8)
1. The composition for resisting propionibacterium acnes and regulating skin microecology is characterized by comprising the following components in parts by weight:
2. a method of preparing the composition of claim 1, comprising the steps of:
(1) weighing the components according to the formula ratio, adding a pH regulator into water, and regulating the pH to 4.0-6.0 to prepare a mixture for later use;
(2) and (2) adding nisin, polylysine, cordycepin and lysozyme into the mixture prepared in the step (1), and stirring and dissolving to obtain the composition.
3. The method according to claim 2, wherein the pH is adjusted to 5.2 to 5.8 in the step (1).
4. A formulation comprising the composition of claim 1.
5. A formulation according to claim 4, wherein the composition according to claim 1 is present in a proportion of 0.1 to 20% by mass of the formulation.
6. The formulation of claim 4, wherein the formulation is at least one of a skin micro-ecological regulating formulation, an anti-acne formulation, or an anti-acne formulation.
7. A composition for use in combating skin infections comprising the composition of claim 1.
8. A disinfectant comprising the composition of claim 1.
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| CN114558109A (en) * | 2022-03-23 | 2022-05-31 | 武汉珈诗丽科技有限公司 | Application of donkey-hide gelatin glycopeptide in preparation of skin micro-ecological regulating preparation |
| CN114712283A (en) * | 2022-04-12 | 2022-07-08 | 北京至乐界生物科技有限公司 | Oil-control acne-clearing composition and application thereof in skin care products |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114558109A (en) * | 2022-03-23 | 2022-05-31 | 武汉珈诗丽科技有限公司 | Application of donkey-hide gelatin glycopeptide in preparation of skin micro-ecological regulating preparation |
| CN114558109B (en) * | 2022-03-23 | 2024-05-28 | 武汉珈诗丽科技有限公司 | Application of donkey-hide gelatin glycopeptide in preparing skin microecological preparation |
| CN114712283A (en) * | 2022-04-12 | 2022-07-08 | 北京至乐界生物科技有限公司 | Oil-control acne-clearing composition and application thereof in skin care products |
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