CN111035651A - Potassium supplementing preparation for improving taste and relieving stomach irritation and preparation method thereof - Google Patents

Potassium supplementing preparation for improving taste and relieving stomach irritation and preparation method thereof Download PDF

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CN111035651A
CN111035651A CN201911319309.6A CN201911319309A CN111035651A CN 111035651 A CN111035651 A CN 111035651A CN 201911319309 A CN201911319309 A CN 201911319309A CN 111035651 A CN111035651 A CN 111035651A
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potassium
concentration
preparation
xanthan gum
supplement
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孙庆
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis

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Abstract

The invention relates to the field of medical products, in particular to a formula and a preparation method of an oral potassium supplement preparation. Mainly relates to oral emulsion of potassium sources such as potassium chloride, potassium citrate, potassium magnesium aspartate and the like. The potassium supplement preparation has good taste, can alleviate the stimulation to the stomach of a patient, and can improve the potassium in blood and the compliance of the patient.

Description

Potassium supplementing preparation for improving taste and relieving stomach irritation and preparation method thereof
Technical Field
The invention belongs to the field of medical products, and particularly relates to a formula and a preparation method of an oral potassium supplement preparation for improving taste and relieving gastric irritation.
Background
Potassium is an important trace element in human bodies, and in clinic, patients often reduce the blood potassium due to various reasons such as intake reduction, excessive discharge or abnormal distribution, and hypokalemia can occur when the concentration of the serum potassium in the human bodies is lower than 3.5 mmol/L. Hypokalemia manifested by weakness of limbs, flaccid paralysis, slow or no tendon reflex; nausea, vomiting, abdominal distension, enteroparalysis and the like, and dyspnea, arrhythmia and even sudden death occur in severe cases. The potassium is needed to be supplemented by injection or oral potassium supplementing liquid, the intravenous medication is limited by the concentration and the dropping speed of the medicament because of the medication safety, patients mostly pass through oral potassium supplementing treatment, the potassium is conveniently and safely supplemented by the oral potassium supplementing liquid, but the existing oral potassium supplementing liquid has poor mouth feel, is easy to cause rejection of the patients and has poor compliance of the patients. For example, the existing potassium chloride potassium-supplementing oral liquid has extremely salty taste, is difficult to be taken in the mouth, has great rejection degree for patients, has great stimulation to the stomach after being taken in the mouth, causes vomiting and stomach discomfort after being taken by many patients, and cannot achieve the treatment purpose.
At present, no existing technical scheme for solving the problem of poor mouth feel of oral potassium liquid is searched. When the potassium supplementing liquid is prepared, a proper amount of auxiliary agents are added to cover the salty and bitter taste of potassium salt, then various auxiliary materials capable of relieving the gastric irritation are added to relieve the gastric irritation, the oral liquid is prepared into an emulsion form through layer-by-layer screening, coagulum can be formed due to improper adding sequence of the raw materials in the process of preparing the emulsion, and various problems in the preparation process are solved through tests and reasoning, so that the oral potassium emulsion is obtained.
Disclosure of Invention
An object of the present invention is to provide a potassium-supplementing composition for alleviating gastric irritation, which can alleviate gastric irritation caused by oral potassium-supplementing.
In order to achieve the purpose, the technical scheme of the invention is as follows:
the potassium supplement composition comprises xanthan gum, milk powder, potassium and water.
Further, the potassium is potassium chloride or/and potassium citrate or/and potassium magnesium aspartate.
Further, the potassium also includes potassium glutamate and potassium acetate.
Furthermore, potassium citrate oral potassium supplement preparations are often used for treating hyperplorinated hypokalemia.
Further, the water is purified water, and can also be replaced by drinkable solvent capable of dissolving xanthan gum and milk powder.
The potassium supplement preparation is in an emulsion form, and the viscosity of the potassium supplement preparation is approximately equal to that of yoghourt.
Furthermore, the concentration of the xanthan gum in the potassium supplementing composition is 2-3mg/ml, the concentration of the milk powder is 80-120mg/ml, and the concentration of the potassium chloride or potassium citrate is 50-60 mg/ml.
Preferably, the xanthan gum concentration is 3mg/ml, the milk powder concentration is 100mg/ml, and the potassium chloride or potassium citrate concentration is 60 mg/ml.
The other purpose of the present invention is to provide a potassium-supplementing preparation for alleviating the irritation of the stomach by oral potassium supplementation, which can alleviate the irritation of the stomach by oral potassium supplementation and also improve the salty taste of the oral potassium supplementation.
In order to achieve the purpose, the technical scheme of the invention is as follows:
the potassium supplement preparation comprises xanthan gum, milk powder, potassium, water and stevioside.
Further, the concentration of the xanthan gum in the potassium supplement preparation is 2-3mg/ml, the concentration of the milk powder is 80-120mg/ml, the concentration of potassium chloride or potassium citrate is 50-60mg/ml, and the concentration of stevioside is 7-8 mg/ml.
Preferably, the xanthan gum concentration is 3mg/ml, the milk powder concentration is 100mg/ml, the potassium chloride or potassium citrate concentration is 60mg/ml, and the stevioside concentration is 7 mg/ml.
The invention also aims to provide a preparation method of the potassium supplement preparation for relieving the gastric irritation. The method is simple to operate and suitable for industrial production.
In order to achieve the purpose, the technical scheme of the invention is as follows:
the method comprises the steps of stirring and mixing milk powder, xanthan gum and stevioside uniformly, then adding water and mixing uniformly, and then adding potassium and mixing uniformly to obtain the potassium supplement preparation.
Further, the preparation method comprises the steps of stirring and uniformly mixing the milk powder, the xanthan gum and the stevioside, then adding water, stirring and uniformly mixing to enable the concentration of the xanthan gum to be 2-3mg/ml, and finally adding potassium, stirring and uniformly mixing to obtain the potassium supplement preparation.
Further, the obtained potassium supplement preparation is sterilized at ultra high temperature and then packaged.
Further, the obtained potassium supplement preparation can also be packaged after being sterilized by pasteurization.
Furthermore, the package is generally made into strips by using tetra Pak paper, and 25ml of tetra Pak paper is packaged in strips. Other containers capable of being sealed in a dark place can also be used for packaging.
Further, the packaged potassium supplement preparation can be stored at normal temperature for more than half a year.
Further, the packaged potassium supplement preparation is opened and stored at 0-4 deg.C for administration, and is used up within 24 hours.
The fourth purpose of the invention is to provide an oral potassium-supplementing preparation for alleviating gastric irritation, which can be prepared by adding stevioside to cover bitter taste and adding other auxiliary materials for improving taste.
The invention has the beneficial effects that:
(1) the potassium supplement preparation provided by the invention has the advantages that the taste is obviously improved, the stimulation to the stomach can be relieved, the compliance of patients is improved, the blood potassium effect of the patients can be quickly improved, the storage condition is mild, and the potassium supplement preparation is hermetically stored at normal temperature for more than half a year.
(2) The potassium supplement preparation provided by the invention has the advantages of simple preparation process and easily obtained raw materials.
Detailed Description
The examples are given for the purpose of better illustration of the invention, but the invention is not limited to the examples. Therefore, those skilled in the art should make insubstantial modifications and adaptations to the embodiments of the present invention in light of the above teachings and remain within the scope of the invention.
EXAMPLE 1 sequential testing of Potassium supplement formulations
Scheme A: the water and the xanthan gum are stirred and mixed evenly, the xanthan gum is coagulated, and the test fails.
Scheme B: the water and the milk powder are stirred and mixed evenly, then the xanthan gum is added and stirred, at the moment, the xanthan gum is easy to form coagulum, and the test fails.
Scheme C: the milk powder and the xanthan gum are stirred and mixed uniformly, then the water is added and stirred and mixed uniformly, the stevioside is added and stirred and mixed uniformly, finally the potassium chloride is added and stirred and mixed uniformly, and the viscosity is increased.
Scheme D: mixing milk powder, xanthan gum and stevioside, adding water, mixing, adding potassium chloride, mixing, and increasing viscosity.
Scheme E: mixing milk powder, xanthan gum, stevioside and potassium chloride, adding water, and stirring to obtain a mixture with no viscosity increase.
The effect of the various protocols is shown in table 1:
table 1 raw material sequence test results table
Test of A B C D E
Effect Forming gel blocks Forming gel blocks Viscosity increase Viscosity increase The viscosity is not increased
And (4) conclusion: the xanthan gum is mixed with the milk powder and then added with water, no coagulum is formed, the potassium chloride is added at last, otherwise the thickening effect of the xanthan gum is influenced, and the final concentration of the xanthan gum is 2-3 mg/ml.
Example 2 xanthan gum concentration test
Adding xanthan gum, milk powder and water in sequence, stirring and mixing uniformly, wherein the water is 90ml, the milk powder is 10g, the xanthan gum is added according to the amount of 0.1-1.0, and the viscosity condition is recorded as shown in Table 2.
Table 2 xanthan gum concentration test table
Figure BDA0002326713950000041
And (4) conclusion: when the concentration of the xanthan gum is 0.2-0.3g/100ml, the viscosity of the mixture reaches the requirement.
EXAMPLE 3 milk powder concentration test
According to the sequence of milk powder, xanthan gum, stevioside, water and potassium chloride, 0.2g of xanthan gum, 0.8g of stevioside, 90ml of water and 6g of potassium chloride are sequentially added and stirred to be mixed uniformly, the milk powder is tested from 8 to 14g, and the results are recorded, wherein the conditions are shown in a table 3:
table 3 milk powder concentration test table
Figure BDA0002326713950000051
And (4) conclusion: the milk powder has a concentration of 8-14g/ml and meets the requirements on mouthfeel.
Example 4 stevioside concentration test
Adding milk powder, xanthan gum, stevioside, water and potassium chloride in sequence, stirring and uniformly mixing, wherein 90ml of water, 0.2g of xanthan gum, 10g of milk powder, 6g of potassium chloride and 0.5-0.9g of stevioside are sequentially added, sequentially testing, and recording results, wherein the conditions are shown in a table 4:
table 4 stevioside concentration test table
Raw materials A B C D E
Water (W) 90 90 90 90 90
Xanthan gum (g) 0.3 0.3 0.3 0.3 0.3
Milk powder (g) 10 10 10 10 10
Stevioside (g) 0.5 0.6 0.7 0.8 0.9
Potassium chloride (g) 6 6 6 6 6
Taste of the product Salty taste Salty taste Can be used for Can be used for Is too sweet
And (4) conclusion: the stevioside concentration is 0.7-0.8g/100 ml.
EXAMPLE 5 Potassium chloride concentration test
According to the sequence of milk powder, xanthan gum, stevioside, water and potassium chloride, the materials are sequentially added and stirred to be uniformly mixed, wherein 90ml of water, 0.2g of xanthan gum, 10g of milk powder, 0.7g of stevioside and 5-10g of potassium chloride are sequentially tested, and the test conditions are shown in a table 5:
TABLE 5 test Table for Potassium chloride concentration
Raw materials A B C D E F
Water (W) 90 90 90 90 90 90
Xanthan gum (g) 0.2 0.2 0.2 0.2 0.2 0.2
Milk powder (g) 10 10 10 10 10 10
Stevioside (g) 0.7 0.7 0.7 0.7 0.7 0.7
Potassium chloride (g) 5 6 7 8 9 10
Taste of the product Can be used for Can be used for Salty taste Salty taste Salty taste Salty taste
And (4) conclusion: the potassium chloride concentration is 5-6g/100ml, and the taste meets the requirement.
EXAMPLE 6 Potassium citrate concentration test
According to the sequence of milk powder, xanthan gum, stevioside, water and potassium citrate, the materials are sequentially added and stirred to be uniformly mixed, 90ml of water, 0.3g of xanthan gum, 10g of milk powder, 0.8g of stevioside and 5-10g of potassium citrate are sequentially tested, and the test conditions are shown in a table 6:
table 6 potassium citrate concentration test table
Figure BDA0002326713950000061
And (4) conclusion: the potassium citrate concentration is 5-6g/100ml, and the taste meets the requirement.
Finally, the above embodiments are only for illustrating the technical solutions of the present invention and not for limiting, although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions may be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all of them should be covered in the claims of the present invention.

Claims (10)

1. A potassium supplement composition for improving mouthfeel and alleviating gastric irritation, said composition comprising xanthan gum, milk powder, potassium, and water.
2. The potassium supplement composition according to claim 1, wherein the potassium is potassium chloride or/and potassium citrate or/and potassium magnesium aspartate.
3. The potassium supplement composition of claim 2, wherein the concentration of xanthan gum in the potassium supplement formulation is 2-3mg/ml, the concentration of milk powder is 80-120mg/ml, and the concentration of potassium chloride or potassium citrate is 50-60 mg/ml.
4. The potassium supplement composition of claim 2, wherein the concentration of xanthan gum in the potassium supplement formulation is 3mg/ml, the concentration of milk powder is 100mg/ml, and the concentration of potassium chloride or potassium citrate is 60 mg/ml.
5. A potassium supplement formulation for alleviating gastric irritation, said potassium supplement formulation comprising a composition according to any one of claims 1 to 4 and a steviol glycoside.
6. The potassium supplement preparation according to claim 5, wherein the concentration of xanthan gum in the potassium supplement preparation is 2-3mg/ml, the concentration of milk powder is 80-120mg/ml, the concentration of potassium chloride or potassium citrate is 50-60mg/ml, and the concentration of stevioside is 7-8 mg/ml.
7. The potassium supplement preparation according to claim 5, wherein the concentration of xanthan gum in the potassium supplement preparation is 3mg/ml, the concentration of milk powder is 100mg/ml, the concentration of potassium chloride or potassium citrate is 60mg/ml, and the concentration of stevioside is 8 mg/ml.
8. The preparation method of the potassium supplement preparation according to any one of claims 5 to 7, characterized in that the preparation method comprises the steps of uniformly mixing xanthan gum, milk powder and stevioside, adding water, uniformly mixing until the concentration of the xanthan gum is 2-3mg/ml, and finally adding potassium, uniformly mixing and stirring to obtain the potassium supplement preparation.
9. The method of claim 8, wherein the potassium supplement formulation is packaged after ultra high temperature sterilization.
10. Use of the composition of claim 1 for the preparation of an oral potassium supplement formulation.
CN201911319309.6A 2019-12-19 2019-12-19 Potassium supplementing preparation for improving taste and relieving stomach irritation and preparation method thereof Pending CN111035651A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216237A (en) * 1978-05-11 1980-08-05 Smith Walton J Potassium-supplement composition
US20110195172A1 (en) * 2008-09-05 2011-08-11 Inge Elisabeth Maria Deutz Beverages comprising potassium
CN106138089A (en) * 2016-08-16 2016-11-23 天津市聚星康华医药科技有限公司 A kind of fluid infusion salt oral gel and preparation method thereof
CN107205464A (en) * 2014-11-19 2017-09-26 卡尔玛纳有限公司 ORT composition and its method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216237A (en) * 1978-05-11 1980-08-05 Smith Walton J Potassium-supplement composition
US20110195172A1 (en) * 2008-09-05 2011-08-11 Inge Elisabeth Maria Deutz Beverages comprising potassium
CN107205464A (en) * 2014-11-19 2017-09-26 卡尔玛纳有限公司 ORT composition and its method
CN106138089A (en) * 2016-08-16 2016-11-23 天津市聚星康华医药科技有限公司 A kind of fluid infusion salt oral gel and preparation method thereof

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