CN111012859A - Bacteriostatic external pill of composite biological preparation - Google Patents
Bacteriostatic external pill of composite biological preparation Download PDFInfo
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- CN111012859A CN111012859A CN201911398176.6A CN201911398176A CN111012859A CN 111012859 A CN111012859 A CN 111012859A CN 201911398176 A CN201911398176 A CN 201911398176A CN 111012859 A CN111012859 A CN 111012859A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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Abstract
The invention discloses a composite biological preparation bacteriostatic external pill which is characterized by comprising the following raw materials: the preparation process comprises the steps of pretreatment, soaking, cutting, scalding, drying, crushing, preparation of extracts, mixing, pelleting and packaging. By adopting the technical scheme, because the dried alum, the pear juice fermentation product filtrate, the rosewood oil, the menthol and the borneol are added, the pH value of the bacteriostatic lotion is adjusted, and meanwhile, the antibacterial effect is enhanced; because the traditional Chinese medicine extracting solution contains the dandelion polyphenol, the dewaxed wormwood volatile oil, the fructus cnidii extracting solution, the glabrous greenbrier rhizome extracting solution and the wild lily extracting solution, the formula of each component accords with the comprehensive effect, has the functions of bacteriostasis, heat clearing and detoxifying, has the pharmacological actions of anti-inflammation, antibiosis and antivirus, and has low cost.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine preparations, in particular to a bacteriostatic external pill of a composite biological preparation.
Background
The gynecological common diseases mainly comprise inflammation of external genitalia and inflammation of internal genitalia, mainly comprise vaginitis, cervicitis, pelvic inflammation, annexitis and the like, are often accompanied by symptoms of pruritus, bleeding and the like, and even affect the mental health and fertility of women in severe cases, but most of the medicines in the market are taken and cleaned, and the medicines contain more antibiotic components, have great side effects and take effect slowly. The pill can be used for external application, and because the medicine in the pill exists in the state of tiny particles, the dissolution rate and bioavailability of the insoluble medicine can be improved, and the pill has quick-acting and high-efficiency effects. The pill can be made into various topical pills according to requirements, and can act on local parts such as eyes, ears, nose, rectum, vagina, etc., compared with liquid topical preparation, the pill has the advantages of high local drug concentration and bioavailability, good stability, long-lasting effect, convenient use, etc.
Disclosure of Invention
The invention provides a bacteriostatic external pill of a composite biological preparation.
In order to solve the technical problems, the technical scheme of the invention is that the bacteriostatic external pellet of the compound biological preparation comprises the following raw materials: the preparation process comprises the steps of pretreatment, soaking, cutting, scalding, drying, crushing, preparation of extracts, mixing, pelleting and packaging.
Further, the bacteriostatic external pill of the compound biological preparation comprises the following components in parts by weight: 2-5 parts of dandelion, 20-30 parts of folium artemisiae argyi, 4-6 parts of fructus cnidii, 3-6 parts of rhizoma smilacis glabrae, 15-18 parts of wild lily, 1-3 parts of dried alum, 8-16 parts of pear juice fermentation product filtrate, 2-5 parts of rosewood oil, 4-8 parts of menthol and 5-10 parts of borneol.
Further, the bacteriostatic external pill of the compound biological preparation comprises the following components in parts by weight: 3-4 parts of dandelion, 24-28 parts of folium artemisiae argyi, 5-6 parts of fructus cnidii, 4-5 parts of rhizoma smilacis glabrae, 16-18 parts of wild lily, 2-3 parts of dried alum, 10-12 parts of pear juice fermentation product filtrate, 3-4 parts of rosewood oil, 5-6 parts of menthol and 6-8 parts of borneol.
The bacteriostatic external pellet of the compound biological preparation is characterized in that the preparation method of the pellet comprises the following steps:
(1) pretreatment: selecting qualified raw materials: 2-5 parts of dandelion, 20-30 parts of folium artemisiae argyi, 4-6 parts of fructus cnidii, 3-6 parts of rhizoma smilacis glabrae, 15-18 parts of wild lily, 1-3 parts of dried alum, 8-16 parts of pear juice fermentation product filtrate, 2-5 parts of rosewood oil, 4-8 parts of menthol and 5-10 parts of borneol, and respectively removing impurities, screening, rinsing and removing reed heads.
(2) Soaking: soaking folium Artemisiae Argyi, fructus Cnidii, rhizoma Smilacis Glabrae, and herba Crotalariae sessiliflorae in warm water at 30-50 deg.C for 10-30 min.
(3) Cutting: and (3) cutting the folium artemisiae argyi and the fructus cnidii processed in the step (2) into stock with the length of 5-10 cm.
(4) Scalding: and (3) slicing the glabrous greenbrier rhizome processed in the step (2) to obtain the glabrous greenbrier rhizome slices with the thickness of 0.5-1.5 cm.
(5) Drying: spreading the dandelion treated in the step (1) in a ventilated place, and drying in the shade; respectively putting the wild lily processed in the step (2) into a dryer for drying; respectively putting the folium artemisiae argyi and the fructus cnidii processed in the step (3) into a dryer for drying at a low temperature; and (4) putting the glabrous greenbrier rhizome processed in the step (4) into a dryer for drying.
(6) Crushing: respectively pulverizing herba Taraxaci, folium Artemisiae Argyi, fructus Cnidii, rhizoma Smilacis Glabrae, and wild Bulbus Lilii, respectively sieving with 60-120 mesh sieve to obtain herba Taraxaci powder, folium Artemisiae Argyi powder, fructus Cnidii powder, and rhizoma Smilacis Glabrae powder.
(7) Extracting dandelion: and (3) extracting dandelion by using an ultrasonic-assisted process, putting the dandelion powder obtained in the step (6) into an ultrasonic extraction device, wherein the extracting solution is ethanol, the volume fraction of the ethanol is 40% -60%, and the material-liquid ratio is 1: 15-1: 25, the ultrasonic temperature is 40-60 ℃, the ultrasonic time is 35-60 min, and the extraction times are 2-4 times, so as to obtain the dandelion polyphenol.
(8) Extracting folium artemisiae argyi: using supercritical CO2And (3) extracting folium artemisiae argyi by an extraction process, putting the folium artemisiae argyi powder obtained in the step (6) into a supercritical extraction device to extract folium artemisiae argyi volatile oil, wherein the extraction temperature is 35-40 ℃, the extraction time is 60-100 min, adding the obtained folium artemisiae argyi volatile oil into 2 times of absolute ethyl alcohol, stirring, standing for 8-16 h, carrying out vacuum suction filtration, removing a precipitated waxy component, and recovering ethanol from green leaves at 30 ℃ under reduced pressure to obtain the dewaxed folium artemisiae argyi volatile oil.
(9) Extracting fructus cnidii: soaking the fructus cnidii powder obtained in the step (6) in 200 times of 1% NaOH solution at 22-25 ℃ for 50-70 min, ultrasonically extracting for 8-12 min, adding 10% HCL into the extracting solution, acidifying, centrifuging, taking out the precipitate, adding 5-10 times of methanol into the precipitate for dissolving to obtain a dissolving solution, and filtering the dissolving solution by using a 0.45-micrometer microporous membrane to obtain the fructus cnidii extracting solution.
(10) Extracting rhizoma smilacis glabrae: adding 40-70% ethanol into the glabrous greenbrier rhizome powder obtained in the step (6) according to the material-liquid ratio of 1: 20-1: 30, soaking for 4-8 h, performing ultrasonic extraction for 30-40 min at the water temperature of 60-80 ℃, extracting for 2-4 times, and combining the extracting solutions to obtain the glabrous greenbrier rhizome extracting solution.
(11) Extracting wild lily: adding absolute ethyl alcohol into the wild lily powder obtained in the step (6) according to the material-liquid ratio of 1: 40-1: 60, soaking for 4-6 h, performing ultrasonic extraction at the water temperature of 70-85 ℃ for 20-30 min, repeating the extraction until the extract is colorless, and combining the extract to obtain the wild lily extract.
(12) And (3) fully mixing the dandelion polyphenol obtained in the steps (7), (8), (9) and (10), the dewaxed wormwood volatile oil, the fructus cnidii extracting solution, the rhizoma smilacis glabrae extracting solution and the wild lily extracting solution according to a proportion, sequentially adding dried alum, the pear juice fermentation product filtrate, rosewood oil, menthol and borneol, uniformly mixing, airing and cooling, and beating to strengthen after cooling to prepare a semi-finished product.
(13) And (4) making the semi-finished product obtained in the step (12) into a pill shape through a pill making machine, polishing, placing in a shade place for air drying and shaping, making into the bacteriostatic pellet of the composite biological preparation, and packaging.
Further, drying the wild lily in a dryer at the temperature of 60-70 ℃.
Further, the folium artemisiae argyi and the fructus cnidii are respectively placed into a dryer for drying at a low temperature of 30-40 ℃.
Furthermore, before adding the dried alum, the dried alum is soaked in distilled water for 2-3 h, heated to 70-90 ℃, and naturally cooled to room temperature for use.
By adopting the technical scheme, because the dried alum, the pear juice fermentation product filtrate, the rosewood oil, the menthol and the borneol are added, the pH value of the bacteriostatic lotion is adjusted, and meanwhile, the antibacterial effect is enhanced; because the traditional Chinese medicine extracting solution contains the dandelion polyphenol, the dewaxed wormwood volatile oil, the fructus cnidii extracting solution, the glabrous greenbrier rhizome extracting solution and the wild lily extracting solution, the formula of each component accords with the comprehensive effect, has the functions of bacteriostasis, heat clearing and detoxifying, has the pharmacological actions of anti-inflammation, antibiosis and antivirus, and has low cost.
Detailed Description
The following further describes the embodiments of the present invention. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
The first embodiment is as follows:
the bacteriostatic external pellet of the compound biological preparation comprises the following raw materials in parts by weight: 2 parts of dandelion, 20 parts of folium artemisiae argyi, 4 parts of fructus cnidii, 3 parts of rhizoma smilacis glabrae, 15 parts of wild lily, 1 part of dried alum, 8 parts of pear juice fermentation product filtrate, 2 parts of rosewood oil, 4 parts of menthol and 5 parts of borneol.
The preparation method of the pellet comprises the following steps:
(1) pretreatment: selecting qualified raw materials: 2 parts of dandelion, 20 parts of folium artemisiae argyi, 4 parts of fructus cnidii, 3 parts of rhizoma smilacis glabrae, 15 parts of wild lily, 1 part of dried alum, 8 parts of pear juice fermentation product filtrate, 2 parts of rosewood oil, 4 parts of menthol and 5 parts of borneol, and respectively removing impurities, screening, rinsing and removing reed heads.
(2) Soaking: soaking folium Artemisiae Argyi, fructus Cnidii, rhizoma Smilacis Glabrae, and herba Crotalariae sessiliflorae in warm water at 30 deg.C for 10 min.
(3) Cutting: and (3) cutting the folium artemisiae argyi and the fructus cnidii processed in the step (2) into 5 cm-long prepared materials.
(4) Scalding: and (3) slicing the glabrous greenbrier rhizome processed in the step (2) to be 0.5cm in thickness.
(5) Drying: spreading the dandelion treated in the step (1) in a ventilated place, and drying in the shade; respectively putting the wild lily processed in the step (2) into a dryer for drying, wherein the drying temperature is 60 ℃; respectively putting the folium artemisiae argyi and the fructus cnidii processed in the step (3) into a dryer for drying at a low temperature of 30 ℃; and (4) putting the glabrous greenbrier rhizome processed in the step (4) into a dryer for drying.
(6) Crushing: respectively pulverizing herba Taraxaci, folium Artemisiae Argyi, fructus Cnidii, rhizoma Smilacis Glabrae, and wild Bulbus Lilii, respectively sieving with 60 mesh sieve to obtain herba Taraxaci powder, folium Artemisiae Argyi powder, fructus Cnidii powder, and rhizoma Smilacis Glabrae powder.
(7) Extracting dandelion: and (3) extracting dandelion by using an ultrasonic-assisted process, putting the dandelion powder obtained in the step (6) into an ultrasonic extraction device, wherein the extracting solution is ethanol, the volume fraction of the ethanol is 40%, and the material-liquid ratio is 1: 15, the ultrasonic temperature is 40 ℃, the ultrasonic time is 35min, and the extraction times are 2 times, so as to obtain the dandelion polyphenol.
(8) Extracting folium artemisiae argyi: using supercritical CO2And (3) extracting folium artemisiae argyi by an extraction process, putting the folium artemisiae argyi powder obtained in the step (6) into a supercritical extraction device to extract folium artemisiae argyi volatile oil, wherein the extraction temperature is 35 ℃, the extraction time is 60min, adding the obtained folium artemisiae argyi volatile oil into 2 times of absolute ethyl alcohol, stirring, standing for 8h, carrying out vacuum filtration, removing a precipitated waxy component, and recovering ethanol from green leaves at 30 ℃ under reduced pressure to obtain the dewaxed folium artemisiae argyi volatile oil.
(9) Extracting fructus cnidii: soaking the fructus cnidii powder obtained in the step (6) in 200 times of 1% NaOH solution at 22 ℃ for 50min, ultrasonically extracting for 8min, adding 10% HCL into the extracting solution, acidifying, centrifuging, taking out precipitate, adding 5 times of methanol into the precipitate, dissolving to obtain a dissolving solution, and filtering the dissolving solution by using a 0.45-micrometer microporous membrane to obtain the fructus cnidii extracting solution.
(10) Extracting rhizoma smilacis glabrae: adding 40% ethanol into the rhizoma smilacis glabrae powder obtained in the step (6) according to the material-liquid ratio of 1:20, soaking for 4h, performing ultrasonic extraction for 30min at the water temperature of 60 ℃, extracting for 2 times, and combining the extracting solutions to obtain the rhizoma smilacis glabrae extracting solution.
(11) Extracting wild lily: adding absolute ethyl alcohol into the wild lily powder obtained in the step (6) according to the material-liquid ratio of 1:40, soaking for 4h, performing ultrasonic extraction at the water temperature of 70 ℃ for 20min, repeating the extraction until the extract is colorless, and combining the extract to obtain a wild lily extract.
(12) Fully mixing the dandelion polyphenol obtained in the steps (7), (8), (9) and (10), the dewaxed wormwood volatile oil, the fructus cnidii extract, the rhizoma smilacis glabrae extract and the wild lily extract according to a proportion, sequentially adding dried alum, the pear juice fermentation product filtrate, rosewood oil, menthol and borneol, uniformly mixing, airing and cooling, beating to be forceful after cooling to prepare a semi-finished product, before adding the dried alum, soaking the dried alum in distilled water for 2 hours, heating to 70 ℃, and naturally cooling to room temperature for use.
(13) And (4) making the semi-finished product obtained in the step (12) into a pill shape through a pill making machine, polishing, placing in a shade place for air drying and shaping, making into the bacteriostatic pellet of the composite biological preparation, and packaging.
Example two:
the bacteriostatic external pellet of the compound biological preparation comprises the following raw materials in parts by weight: 3 parts of dandelion, 25 parts of folium artemisiae argyi, 5 parts of fructus cnidii, 4 parts of rhizoma smilacis glabrae, 16 parts of wild lily, 2 parts of dried alum, 12 parts of pear juice fermentation product filtrate, 3 parts of rosewood oil, 6 parts of menthol and 8 parts of borneol.
The preparation method of the pellet comprises the following steps:
(1) pretreatment: selecting qualified raw materials: 3 parts of dandelion, 25 parts of folium artemisiae argyi, 5 parts of fructus cnidii, 4 parts of rhizoma smilacis glabrae, 16 parts of wild lily, 2 parts of dried alum, 12 parts of pear juice fermentation product filtrate, 3 parts of rosewood oil, 6 parts of menthol and 8 parts of borneol, and respectively removing impurities, screening, rinsing and removing the reed heads.
(2) Soaking: soaking folium Artemisiae Argyi, fructus Cnidii, rhizoma Smilacis Glabrae, and herba Crotalariae sessiliflorae in warm water at 35 deg.C for 20 min.
(3) Cutting: and (3) cutting the folium artemisiae argyi and the fructus cnidii processed in the step (2) into stock materials with the length of 8 cm.
(4) Scalding: and (3) slicing the glabrous greenbrier rhizome processed in the step (2) to the thickness of 1 cm.
(5) Drying: spreading the dandelion treated in the step (1) in a ventilated place, and drying in the shade; respectively putting the wild lily processed in the step (2) into a dryer for drying, wherein the drying temperature is 65 ℃; respectively putting the folium artemisiae argyi and the fructus cnidii processed in the step (3) into a dryer for drying at a low temperature of 35 ℃; and (4) putting the glabrous greenbrier rhizome processed in the step (4) into a dryer for drying.
(6) Crushing: respectively pulverizing herba Taraxaci, folium Artemisiae Argyi, fructus Cnidii, rhizoma Smilacis Glabrae, and wild Bulbus Lilii, respectively sieving with 90 mesh sieve to obtain herba Taraxaci powder, folium Artemisiae Argyi powder, fructus Cnidii powder, and rhizoma Smilacis Glabrae powder.
(7) Extracting dandelion: and (3) extracting dandelion by using an ultrasonic-assisted process, putting the dandelion powder obtained in the step (6) into an ultrasonic extraction device, wherein the extracting solution is ethanol, the volume fraction of the ethanol is 50%, and the material-liquid ratio is 1:20, performing ultrasonic treatment at 50 deg.C for 45min for 3 times to obtain taraxacum polyphenol.
(8) Extracting folium artemisiae argyi: using supercritical CO2And (3) extracting folium artemisiae argyi by an extraction process, putting the folium artemisiae argyi powder obtained in the step (6) into a supercritical extraction device to extract folium artemisiae argyi volatile oil, wherein the extraction temperature is 38 ℃, the extraction time is 80min, adding the obtained folium artemisiae argyi volatile oil into 2 times of absolute ethyl alcohol, stirring, standing for 12h, carrying out vacuum filtration, removing a precipitated waxy component, and recovering ethanol from green leaves at 30 ℃ under reduced pressure to obtain the dewaxed folium artemisiae argyi volatile oil.
(9) Extracting fructus cnidii: soaking the fructus cnidii powder obtained in the step (6) in 200 times of 1% NaOH solution at 23 ℃ for 60min, ultrasonically extracting for 10min, adding 10% HCL into the extracting solution, acidifying, centrifuging, taking out precipitate, adding 8 times of methanol into the precipitate, dissolving to obtain a dissolving solution, and filtering the dissolving solution by using a 0.45-micrometer microporous membrane to obtain the fructus cnidii extracting solution.
(10) Extracting rhizoma smilacis glabrae: adding 50% ethanol into the rhizoma smilacis glabrae powder obtained in the step (6) according to the material-liquid ratio of 1:25, soaking for 6h, performing ultrasonic extraction for 35min at the water temperature of 70 ℃, extracting for 3 times, and combining the extracting solutions to obtain the rhizoma smilacis glabrae extracting solution.
(11) Extracting wild lily: adding anhydrous ethanol into the wild lily powder obtained in the step (6) at a material-liquid ratio of 1:50, soaking for 5h, performing ultrasonic extraction at the water temperature of 80 ℃ for 25min, repeating the extraction until the extract is colorless, and combining the extract to obtain a wild lily extract.
(12) Fully mixing the dandelion polyphenol obtained in the steps (7), (8), (9) and (10), the dewaxed wormwood volatile oil, the fructus cnidii extract, the rhizoma smilacis glabrae extract and the wild lily extract according to a proportion, sequentially adding dried alum, the pear juice fermentation product filtrate, rosewood oil, menthol and borneol, uniformly mixing, airing and cooling, beating to be forceful after cooling to prepare a semi-finished product, before adding the dried alum, soaking the dried alum in distilled water for 2.5h, heating to 80 ℃, naturally cooling to room temperature, and then using.
(13) And (4) making the semi-finished product obtained in the step (12) into a pill shape through a pill making machine, polishing, placing in a shade place for air drying and shaping, making into the bacteriostatic pellet of the composite biological preparation, and packaging.
Example three:
the bacteriostatic external pellet of the compound biological preparation comprises the following raw materials in parts by weight: 5 parts of dandelion, 30 parts of folium artemisiae argyi, 6 parts of fructus cnidii, 6 parts of rhizoma smilacis glabrae, 18 parts of wild lily, 3 parts of dried alum, 16 parts of pear juice fermentation product filtrate, 5 parts of rosewood oil, 8 parts of menthol and 10 parts of borneol.
The preparation method of the pellet comprises the following steps:
(1) pretreatment: selecting qualified raw materials: 5 parts of dandelion, 30 parts of folium artemisiae argyi, 6 parts of fructus cnidii, 6 parts of rhizoma smilacis glabrae, 18 parts of wild lily, 3 parts of dried alum, 16 parts of pear juice fermentation product filtrate, 5 parts of rosewood oil, 8 parts of menthol and 10 parts of borneol, and respectively removing impurities, screening, rinsing and removing reed heads.
(2) Soaking: soaking folium Artemisiae Argyi, fructus Cnidii, rhizoma Smilacis Glabrae, and herba Crotalariae sessiliflorae in warm water at 50 deg.C for 30 min.
(3) Cutting: and (3) cutting the folium artemisiae argyi and the fructus cnidii processed in the step (2) into stock materials with the length of 10 cm.
(4) Scalding: and (3) slicing the glabrous greenbrier rhizome processed in the step (2) to the thickness of 1.5 cm.
(5) Drying: spreading the dandelion treated in the step (1) in a ventilated place, and drying in the shade; respectively putting the wild lily processed in the step (2) into a dryer for drying, wherein the drying temperature is 70 ℃; respectively putting the folium artemisiae argyi and the fructus cnidii processed in the step (3) into a dryer for drying at a low temperature of 40 ℃; and (4) putting the glabrous greenbrier rhizome processed in the step (4) into a dryer for drying.
(6) Crushing: respectively pulverizing herba Taraxaci, folium Artemisiae Argyi, fructus Cnidii, rhizoma Smilacis Glabrae, and wild Bulbus Lilii, respectively sieving with 120 mesh sieve to obtain herba Taraxaci powder, folium Artemisiae Argyi powder, fructus Cnidii powder, and rhizoma Smilacis Glabrae powder.
(7) Extracting dandelion: and (3) extracting dandelion by using an ultrasonic-assisted process, putting the dandelion powder obtained in the step (6) into an ultrasonic extraction device, wherein the extracting solution is ethanol, the volume fraction of the ethanol is 60%, and the material-liquid ratio is 1:25, performing ultrasonic treatment at 60 deg.C for 60min for 4 times to obtain taraxacum polyphenol.
(8) Extracting folium artemisiae argyi: using supercritical CO2And (3) extracting folium artemisiae argyi by an extraction process, putting the folium artemisiae argyi powder obtained in the step (6) into a supercritical extraction device to extract folium artemisiae argyi volatile oil, wherein the extraction temperature is 40 ℃, the extraction time is 100min, adding the obtained folium artemisiae argyi volatile oil into 2 times of absolute ethyl alcohol, stirring, standing for 16h, carrying out vacuum filtration, removing a precipitated waxy component, and recovering ethanol from green leaves at 30 ℃ under reduced pressure to obtain the dewaxed folium artemisiae argyi volatile oil.
(9) Extracting fructus cnidii: soaking the fructus cnidii powder obtained in the step (6) in 200 times of 1% NaOH solution at 25 ℃ for 70min, performing ultrasonic extraction for 12min, adding 10% HCL into the extracting solution, acidifying, centrifuging, taking precipitate, adding 10 times of methanol into the precipitate, dissolving to obtain a dissolving solution, and filtering the dissolving solution by using a 0.45-micrometer microporous membrane to obtain the fructus cnidii extracting solution.
(10) Extracting rhizoma smilacis glabrae: adding 70% ethanol into the glabrous greenbrier rhizome powder obtained in the step (6) according to the material-liquid ratio of 1:30, soaking for 4-8 h, performing ultrasonic extraction for 40min at the water temperature of 80 ℃, extracting for 4 times, and combining the extracting solutions to obtain the glabrous greenbrier rhizome extracting solution.
(11) Extracting wild lily: adding absolute ethyl alcohol into the wild lily powder obtained in the step (6) according to the material-liquid ratio of 1:60, soaking for 6h, performing ultrasonic extraction at the water temperature of 85 ℃ for 30min, repeating the extraction until the extract is colorless, and combining the extract to obtain a wild lily extract.
(12) Fully mixing the dandelion polyphenol obtained in the steps (7), (8), (9) and (10), the dewaxed wormwood volatile oil, the fructus cnidii extract, the rhizoma smilacis glabrae extract and the wild lily extract according to a proportion, sequentially adding dried alum, the pear juice fermentation product filtrate, rosewood oil, menthol and borneol, uniformly mixing, airing and cooling, beating to be forceful after cooling to prepare a semi-finished product, before adding the dried alum, soaking the dried alum in distilled water for 3 hours, heating to 90 ℃, and naturally cooling to room temperature for use.
(13) And (4) making the semi-finished product obtained in the step (12) into a pill shape through a pill making machine, polishing, placing in a shade place for air drying and shaping, making into the bacteriostatic pellet of the composite biological preparation, and packaging.
The pretreatment process of the traditional Chinese medicinal materials directly influences the quality of the medicinal materials, thereby influencing the safety and the effectiveness of the preparation. Comprises screening, rinsing, removing rhizoma Phragmitis, and cutting
During screening, screens of different specifications are selected according to different properties of medicinal materials and impurities, mixed silt, impurities and the like are screened out, manual screening or mechanical screening can be selected, bamboo screens, copper screens or iron wire screens are selected for manual screening, and oscillating commercial medicine screening machines or electric medicine screening machines are used for mechanical screening. Rinsing, washing or rinsing the medicinal materials to remove impurities and toxic components, cleaning soil, dust and mildew on the surface of the medicinal materials with clear water, and optionally cleaning with a drum-type medicine washing machine.
The reed head refers to the parts of residual stems, leaves, stems, rhizomes and the like remained on the root and rhizome medicinal materials, and the reed head is removed, so that the medicinal materials can be cleaner, and the subsequent processing is convenient.
The medicinal materials are cut into pieces, sections, blocks and the like suitable for production, and the soaked Chinese medicinal materials are softened, so that the cutting is facilitated.
The dandelion is a flower medicinal material, and is spread out and dried in the shade in a ventilated place, so that the loss of effective components can be avoided. The folium artemisiae argyi and the fructus cnidii are soaked in warm water and then dried at low temperature, so that the effective ingredients are kept, and meanwhile, the later-stage crushing processing is facilitated. The glabrous greenbrier rhizome is a root medicinal material, and is dried after being sliced, so that the medicinal material is good in color and luster, sufficient in powder property, capable of disinfecting, killing insects and preventing mildew, and beneficial to storage of the medicinal material.
The dandelion has good functions of clearing heat and removing toxicity, inhibiting bacteria and resisting inflammation, and the dandelion polyphenol in the dandelion has the functions of resisting bacteria, resisting virus and the like. The following table shows the effect of each parameter on the extraction amount of polyphenol from dandelion:
TABLE influence of parameters on the extraction of polyphenols from Dandelion
Factors influencing the extraction of the polyphenol of the dandelion comprise the volume of ethanol, the material-liquid ratio, the ultrasonic temperature, the extraction time and the extraction times, and as can be seen from the table I, the extraction content of the polyphenol of the dandelion is the highest under the conditions of the second group of parameters.
The extract of the folium artemisiae argyi: the volatile oil of folium Artemisiae Argyi is the main medicinal effective component of folium Artemisiae Argyi, and has antiinflammatory, antiallergic, antibacterial, and antibacterial effects.
Fructus cnidii is a plant, also called wild carrot seed, which is picked in summer and autumn, and has mild temperament and bitter taste. The fructus Cnidii extract is extracted from fruit of cnidium monnieri (L.) DC of Umbelliferae, and contains pinene, isovalerian borneol ester, parsley phenol methyl ether, dihydrocarveol, bergapten, osthole, and isoanisic apigenin. The extract of the fructus cnidii mainly contains osthole, and the external application of the traditional Chinese medicine can treat trichomonas vaginitis, but the single fructus cnidii has poor efficacy and needs to be synthesized with other components into a compound preparation for treatment. The extraction of the cnidium fruit generally adopts a water decoction method, an ethanol ultrasonic extraction method and the like, and different extraction methods have different extraction results on the osthole. The table below shows the osthole extraction content for different extraction methods.
TABLE-Effect of different extraction methods on the extraction of osthole from cnidium fruit
| Extraction method | Cnidium lactone content (mg \ g-l) |
| Water decoction method | 3.784 |
| Ultrasonic extraction method of ethanol | 19.581 |
| Alkaline impregnation process | 20.763 |
| Ultrasonic extraction method by alkali dissolution and acid precipitation | 22.497 |
Therefore, the alkali-dissolution acid-precipitation ultrasonic extraction method is the best extraction method of osthole.
The total alkaloid in the glabrous greenbrier rhizome is a nitrogen-containing organic compound, has the property similar to alkali, and is a very important class in the effective components of the botanical drug. Has antiinflammatory, antibacterial, and antiviral effects.
In summary, the second embodiment is the best embodiment.
The invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, and the scope of protection is still within the scope of the invention.
Claims (7)
1. The bacteriostatic external pill of the compound biological preparation is characterized by comprising the following raw materials: the preparation process comprises the steps of pretreatment, soaking, cutting, scalding, drying, crushing, preparation of extracts, mixing, pelleting and packaging.
2. The bacteriostatic external pellet as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 2-5 parts of dandelion, 20-30 parts of folium artemisiae argyi, 4-6 parts of fructus cnidii, 3-6 parts of rhizoma smilacis glabrae, 15-18 parts of wild lily, 1-3 parts of dried alum, 8-16 parts of pear juice fermentation product filtrate, 2-5 parts of rosewood oil, 4-8 parts of menthol and 5-10 parts of borneol.
3. The bacteriostatic external pellet as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 3-4 parts of dandelion, 24-28 parts of folium artemisiae argyi, 5-6 parts of fructus cnidii, 4-5 parts of rhizoma smilacis glabrae, 16-18 parts of wild lily, 2-3 parts of dried alum, 10-12 parts of pear juice fermentation product filtrate, 3-4 parts of rosewood oil, 5-6 parts of menthol and 6-8 parts of borneol.
4. The bacteriostatic external pellet as claimed in claim 2, wherein the preparation method of the pellet comprises the following steps:
(1) pretreatment: selecting qualified raw materials: 2-5 parts of dandelion, 20-30 parts of folium artemisiae argyi, 4-6 parts of fructus cnidii, 3-6 parts of rhizoma smilacis glabrae, 15-18 parts of wild lily, 1-3 parts of dried alum, 8-16 parts of pear juice fermentation product filtrate, 2-5 parts of rosewood oil, 4-8 parts of menthol and 5-10 parts of borneol, and respectively removing impurities, screening, rinsing and removing reed heads;
(2) soaking: respectively soaking folium Artemisiae Argyi, fructus Cnidii, rhizoma Smilacis Glabrae, and wild Bulbus Lilii in warm water at 30-50 deg.C for 10-30 min;
(3) cutting: cutting the folium artemisiae argyi and the fructus cnidii processed in the step (2) into stock materials with the length of 5-10 cm;
(4) scalding: slicing the glabrous greenbrier rhizome processed in the step (2) to be 0.5-1.5 cm thick;
(5) drying: spreading the dandelion treated in the step (1) in a ventilated place, and drying in the shade; respectively putting the wild lily processed in the step (2) into a dryer for drying; respectively putting the folium artemisiae argyi and the fructus cnidii processed in the step (3) into a dryer for drying at a low temperature; putting the glabrous greenbrier rhizome processed in the step (4) into a dryer for drying;
(6) crushing: respectively crushing dandelion, folium artemisiae argyi, fructus cnidii, rhizoma smilacis glabrae and wild lily, and respectively sieving the crushed materials with a sieve of 60-120 meshes to respectively obtain dandelion powder, folium artemisiae argyi powder, fructus cnidii powder and rhizoma smilacis glabrae powder;
(7) extracting dandelion: and (3) extracting dandelion by using an ultrasonic-assisted process, putting the dandelion powder obtained in the step (6) into an ultrasonic extraction device, wherein the extracting solution is ethanol, the volume fraction of the ethanol is 40% -60%, and the material-liquid ratio is 1: 15-1: 25, performing ultrasonic treatment at 40-60 ℃ for 35-60 min for 2-4 times to obtain dandelion polyphenol;
(8) extracting folium artemisiae argyi: using supercritical CO2Extracting folium artemisiae argyi by an extraction process, putting the folium artemisiae argyi powder obtained in the step (6) into a supercritical extraction device to extract folium artemisiae argyi volatile oil, wherein the extraction temperature is 35-40 ℃, the extraction time is 60-100 min, adding the obtained folium artemisiae argyi volatile oil into 2 times of absolute ethyl alcohol, stirring, standing for 8-16 h, carrying out vacuum suction filtration, removing a precipitated waxy component, and recovering ethanol from green leaves at 30 ℃ under reduced pressure to obtain dewaxed folium artemisiae argyi volatile oil;
(9) extracting fructus cnidii: soaking the fructus cnidii powder obtained in the step (6) in 200 times of 1% NaOH solution at 22-25 ℃ for 50-70 min, ultrasonically extracting for 8-12 min, adding 10% HCL into the extracting solution, acidifying, centrifuging, taking out a precipitate, adding 5-10 times of methanol into the precipitate for dissolving to obtain a dissolving solution, and filtering the dissolving solution by using a 0.45 mu m microporous membrane to obtain a fructus cnidii extracting solution;
(10) extracting rhizoma smilacis glabrae: adding 40-70% ethanol into the glabrous greenbrier rhizome powder obtained in the step (6) according to the material-liquid ratio of 1: 20-1: 30, soaking for 4-8 h, performing ultrasonic extraction for 30-40 min at the water temperature of 60-80 ℃, extracting for 2-4 times, and combining the extracting solutions to obtain a glabrous greenbrier rhizome extracting solution;
(11) extracting wild lily: adding absolute ethyl alcohol into the wild lily powder obtained in the step (6) according to the material-liquid ratio of 1: 40-1: 60, soaking for 4-6 h, performing ultrasonic extraction at the water temperature of 70-85 ℃ for 20-30 min, repeating the extraction until the extract is colorless, and combining the extract to obtain a wild lily extract;
(12) fully mixing the dandelion polyphenol obtained in the steps (7), (8), (9) and (10), the dewaxed wormwood volatile oil, the fructus cnidii extracting solution, the rhizoma smilacis glabrae extracting solution and the wild lily extracting solution according to a proportion, sequentially adding dried alum, the pear juice fermentation product filtrate, rosewood oil, menthol and borneol, uniformly mixing, airing and cooling, and beating to be forceful to prepare a semi-finished product after cooling;
(13) and (4) making the semi-finished product obtained in the step (12) into a pill shape through a pill making machine, polishing, placing in a shade place for air drying and shaping, making into the bacteriostatic pellet of the composite biological preparation, and packaging.
5. The bacteriostatic external pill of composite biological agent as claimed in claim 1, wherein in step (5), the wild lily is dried in a dryer at a temperature of 60-70 ℃.
6. The bacteriostatic external pill of composite biological agent according to claim 1, wherein in the step (5), the folium artemisiae argyi and the fructus cnidii are respectively put into a dryer for drying at a low temperature of 30-40 ℃.
7. The bacteriostatic external pill as claimed in claim 1, wherein in step (12), before adding dried alum, the dried alum is soaked in distilled water for 2-3 h, heated to 70-90 ℃, and naturally cooled to room temperature for use.
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