CN111000734A - Mouthwash effervescent granules and preparation method and use method thereof - Google Patents
Mouthwash effervescent granules and preparation method and use method thereof Download PDFInfo
- Publication number
- CN111000734A CN111000734A CN202010081946.0A CN202010081946A CN111000734A CN 111000734 A CN111000734 A CN 111000734A CN 202010081946 A CN202010081946 A CN 202010081946A CN 111000734 A CN111000734 A CN 111000734A
- Authority
- CN
- China
- Prior art keywords
- mouthwash
- soluble
- effervescent
- dry powder
- pharmacological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0283—Matrix particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Mathematical Physics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a gargle effervescent granule, the formula of which comprises the following components: dandelion root, honeysuckle, coix seed, agastache rugosus, centella asiatica, folium artemisiae argyi, pericarpium citri reticulatae, cellulase, citric acid, sodium bicarbonate, maltitol, xylitol, mannitol, ethanol, polyethylene glycol 6000 and psicose. The invention also discloses a preparation method and a using method of the mouthwash effervescent granule. The invention has the characteristics of long-term use, good cleaning and bacteriostasis effects, convenient use and carrying, and the like.
Description
Technical Field
The invention belongs to the technical field of preparation of mouthwash granules, and particularly relates to mouthwash effervescent granules as well as a preparation method and a use method thereof.
Background
The ① bottled mouthwash is inconvenient to carry, ② mouthwash is divided into health mouthwash and medicinal mouthwash, the health mouthwash only can play a role of refreshing breath, the medicinal mouthwash is mostly chemical substances with sterilization and other effects, and cannot be used for a long time, most of mouthwash in the ③ market is bad in taste, the price is higher than that of ordinary consumers, and the capacity of protecting oral health of Chinese people is limited.
Disclosure of Invention
The invention aims to solve the technical problem of providing a gargle effervescent granule and a preparation method thereof, wherein the gargle effervescent granule can be used for a long time, has good cleaning and antibacterial effects, and is an oral health preparation convenient to use and carry.
The invention is realized in such a way, and provides a gargle effervescent granule, the formula of which comprises the following components: dandelion root, honeysuckle, coix seed, agastache rugosus, centella asiatica, folium artemisiae argyi, pericarpium citri reticulatae, cellulase, citric acid, sodium bicarbonate, maltitol, xylitol, mannitol, ethanol, polyethylene glycol 6000 and psicose.
The invention is realized in such a way, and also provides a preparation method of the mouthwash effervescent granules, which comprises the following steps:
extracting pharmacologically active ingredients from dandelion roots, honeysuckle, coix seeds, agastache rugosus, centella asiatica, folium artemisiae argyi and pericarpium citri reticulatae to respectively obtain water-soluble pharmacologically active dry powder and alcohol-soluble pharmacologically active dry powder;
step two, preparing pharmacological acid particles by using the water-soluble pharmacological active dry powder obtained in the step one;
step three, preparing pharmacological alkaline particles by using the alcohol-soluble pharmacological active dry powder obtained in the step one;
step four, uniformly mixing the pharmacological acidic particles obtained in the step two and the pharmacological alkaline particles obtained in the step three according to a ratio of 1:1 to obtain a finished product of the mouthwash effervescent granules.
The invention is realized in such a way, and also provides a using method of the gargle effervescent granule, which is characterized in that a bag of the gargle effervescent granule is poured into the oral cavity, half mouth of pure water is inhaled to dissolve the gargle effervescent granule and repeatedly rinse the teeth and the oral cavity for 3min, then the gargle effervescent granule is spitted out, and then the oral cavity is repeatedly rinsed by pure water for several times.
Compared with the prior art, the mouthwash effervescent granule, the preparation method and the use method thereof have the following characteristics:
1) the formula of the invention adopts medicinal and edible raw materials, has no toxicity, side effects and irritation, and can be used for a long time;
2) degrading raw material cellulose by enzyme, increasing cell wall pore size, and increasing dissolution of active ingredients (such as polysaccharide, flavone, phenolic acid, alkaloid sterol, etc.). Because of the high water solubility of the plant polysaccharide, precipitation can occur in ethanol, and part of flavone, phenolic acid and alkaloid can be dissolved in ethanol and can not be dissolved in water. After the enzymatic reaction, a mode of firstly extracting water and then extracting alcohol is adopted, so that the pharmacological activity dissolved matters of the plants are effectively retained, and therefore, the breath is more effectively refreshed and the bacteria is inhibited;
3) allulose, xylitol and mannitol are added in the formula, so that the taste and granulation effect of the granules are effectively enhanced, the granules have good sense and are convenient to use, and researches show that allulose also has analgesic and anti-inflammatory effects;
4) respectively preparing water-soluble and alcohol-soluble components into acid agent particles and alkali agent particles of the effervescent tablet, wherein the water-soluble flavone and polysaccharide components have good stability under a weak acid condition, and the alcohol-soluble flavone, alkaloid, sterol and the like have good stability under a weak alkaline condition, so that the water-soluble and alcohol-soluble components are respectively prepared into the acid agent particles and the alkali agent particles to promote the stable existence of the components;
5) the product is disintegrated in the oral cavity when in use, and the plant active substances can be uniformly dispersed by the carbon dioxide generated in the disintegration process, and the product has a certain cleaning effect and is beneficial to cleaning the oral cavity;
6) has the characteristics of convenient taking, quick response, high bioavailability of bioactive substances and the like;
7) the product has moderate price and is convenient to carry.
Detailed Description
In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more apparent, the present invention is further described in detail below with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
In a preferred embodiment of the effervescent mouthwash granule of the present invention, the formulation comprises the following components: dandelion root, honeysuckle, coix seed, agastache rugosus, centella asiatica, folium artemisiae argyi, pericarpium citri reticulatae, cellulase, citric acid, sodium bicarbonate, maltitol, xylitol, mannitol, ethanol, polyethylene glycol 6000 and psicose.
The taraxacum plant belongs to medicine and food homologous perennial herb of Compositae, contains active ingredients such as polysaccharide, flavone, organic acid, phytosterol and the like, and has the effects of clearing away heat and toxic materials, diminishing inflammation, resisting bacteria and viruses, improving the immunity of organisms and the like.
The honeysuckle has the functions of clearing away heat and toxic materials, resisting bacteria and diminishing inflammation and the like, and is mainly clinically applied to diseases such as pyocutaneous disease, diarrhea, exogenous diseases, respiratory tract infection and the like. Researches show that the honeysuckle mainly contains medicinal components such as volatile oil, flavonoid, phenolic acid, triterpenes and the like, and has a good antibacterial effect. The flos Lonicerae extractive solution has unique flavor, and can clean oral cavity, refresh breath, and prevent gingival inflammation and throat inflammation.
The semen Coicis has effects of invigorating spleen, benefiting stomach, clearing heat, invigorating lung, and expelling pus, and has effects of assisting herba Taraxaci and flos Lonicerae in lowering fire, clearing heat, resisting bacteria, relieving inflammation, and invigorating spleen and lung.
Agastache rugosus commonly known as Chenopodium hybridum is mainly used for various internal and external bleeding, carbuncle, cellulitis and pyogenic infections, traumatic injuries and the like in traditional Chinese medicine, and can be added into the gargle granules to effectively prevent gingival bleeding.
Centella asiatica: promoting skin growth, inhibiting ulcer, and treating sore throat, aphtha of the mouth and tongue, and thirst.
Folium artemisiae argyi: has warm nature, bitter taste and no toxicity, and has effects of eliminating dampness, dispelling cold, stopping bleeding, relieving inflammation, relieving asthma, relieving cough, and resisting allergy. The medical records of the past generations are recorded as "essential hemostatic herbs".
Pericarpium citri reticulatae: the hesperidin has the medicinal components of resisting oxidation, eliminating free radicals, eliminating phlegm and stopping cough and the like. Is mainly used for treating cough and excessive phlegm in clinic. The pericarpium citri reticulatae is used as a compatibility agent, so that the peculiar smell can be removed, the flavor can be enhanced, and the effects of reducing phlegm and relieving cough can be achieved.
The D-psicose added into the diet can reduce postprandial blood sugar reaction and improve insulin sensitivity and glucose tolerance.
The invention also discloses a preparation method of the mouthwash effervescent granule, which comprises the following steps:
the method comprises the step one of extracting pharmacologically active ingredients from dandelion roots, honeysuckle, coix seeds, agastache rugosus, centella asiatica, folium artemisiae argyi and pericarpium citri reticulatae to respectively obtain water-soluble pharmacologically active dry powder and alcohol-soluble pharmacologically active dry powder.
And step two, preparing the pharmacological acid particles by using the water-soluble pharmacological active dry powder obtained in the step one.
And step three, preparing the pharmacological alkaline particles by using the alcohol-soluble pharmacological active dry powder obtained in the step one.
Step four, uniformly mixing the pharmacological acidic particles obtained in the step two and the pharmacological alkaline particles obtained in the step three according to a ratio of 1:1 to obtain a finished product of the mouthwash effervescent granules.
The following examples are provided to illustrate the preparation of effervescent mouthwash granules according to the invention.
Example 1
An embodiment of the first process for preparing effervescent mouthwash granules according to the invention comprises the following steps:
step 11, grinding 500g of dandelion root 15-20%, honeysuckle flower 15-20%, coix seed 10-20%, wrinkled gianthyssop herb 5-10%, folium artemisiae argyi 5-10%, centella asiatica 5-10% and pericarpium citri reticulatae 10-20% by weight into powder, frying the powder for 5min at 80 ℃, adding 50 ℃ warm water according to a ratio of 1:20, mixing, and homogenizing.
And step 12, adding 0.5-1% of cellulase, uniformly mixing, carrying out a constant-temperature micro-magnetic stirring water bath reaction for 1h at 50-60 ℃ to dissolve out a large amount of bioactive substances, and centrifuging for 15min at 5000 rpm.
And step 13, carrying out ultrafiltration on the supernatant obtained by centrifugation in the step 12 by 0.22 μm, filtering and concentrating by a nanofiltration membrane of three levels of 1000Da, 500Da and 150Da, collecting all filtrate, and freeze-drying to obtain the water-soluble pharmacologically active dry powder.
Wherein the water-soluble pharmacological activity dry powder mainly comprises polysaccharide, amino acid, water-soluble flavone, phenolic acid and other water-soluble substances.
And step 14, adding 80% ethanol solution with the volume 6 times that of the centrifugal slag obtained in the step 12, stirring and extracting the alcohol-soluble active substances, repeatedly extracting for two times, each time for 30min, centrifuging at 4000rpm for 15min to obtain supernatant, filtering by adopting a multi-stage fine filtering membrane, collecting all filtrate, and freeze-drying to obtain the alcohol-soluble pharmacological active dry powder.
Wherein, the alcohol-soluble pharmacological active dry powder mainly comprises alcohol-soluble flavone, phenolic acid, sterol, terpenoid and volatile oil substances.
And step 15, placing the water-soluble pharmacologically active dry powder obtained in the step 13 into a mortar, adding 150-200 g of allulose, 30-50g of mannitol, 30-50g of xylitol and 100-150 g of citric acid by an equivalent progressive method, uniformly mixing, adding a proper amount of 70% ethanol, mixing to prepare a soft material, sieving with a 20-mesh sieve, extruding and granulating, drying in an oven at 60 ℃ for 1 hour, sieving with the 20-mesh sieve for grading, and sieving with a 75-mesh sieve to remove fine powder to obtain pharmacologically acidic particles.
And step 16, placing the alcohol-soluble pharmacologically active dry powder obtained in the step 14 into a mortar, adding 150-200 g of allulose, 30-50g of mannitol, 30-50g of xylitol and sodium bicarbonate coated by polyethylene glycol 6000 according to an equivalent progressive method, uniformly mixing, adding a proper amount of 70% ethanol, mixing to prepare a soft material, sieving with a 20-mesh sieve, carrying out extrusion granulation, drying in an oven at 60 ℃ for 1 hour, sieving with the 20-mesh sieve for grading, and sieving with a 75-mesh sieve to remove fine powder, thus obtaining the pharmacologically alkaline particles.
In step 16, the sodium bicarbonate coated with polyethylene glycol 6000 is prepared by the following method: heating 150-200 g of polyethylene glycol 6000 at 70-75 ℃ to melt, adding 130-200 g of sodium bicarbonate, mixing uniformly, cooling, crushing, and sieving with a 80-mesh sieve to obtain sodium bicarbonate coated with polyethylene glycol 6000 for later use.
And step 17, uniformly mixing the pharmacological acidic particles obtained in the step 15 and the pharmacological basic particles obtained in the step 16 according to a ratio of 1:1 to obtain mouthwash effervescent particles, and packaging in bags to obtain mouthwash effervescent particle finished products. Each bag is 3-7 g.
The invention also discloses a using method of the mouthwash effervescent granules, which comprises the steps of pouring a bag (5 g per bag) of the mouthwash effervescent granules into the oral cavity, inhaling half-mouth pure water to dissolve the granules, repeatedly rinsing the teeth and the oral cavity, spitting out after 3min, and repeatedly rinsing the oral cavity with pure water for several times.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (7)
1. An effervescent gargle granule is characterized in that the formula comprises the following components: dandelion root, honeysuckle, coix seed, agastache rugosus, centella asiatica, folium artemisiae argyi, pericarpium citri reticulatae, cellulase, citric acid, sodium bicarbonate, maltitol, xylitol, mannitol, ethanol, polyethylene glycol 6000 and psicose.
2. A method of preparing effervescent mouthwash granules according to claim 1, comprising the steps of:
extracting pharmacologically active ingredients from dandelion roots, honeysuckle, coix seeds, agastache rugosus, centella asiatica, folium artemisiae argyi and pericarpium citri reticulatae to respectively obtain water-soluble pharmacologically active dry powder and alcohol-soluble pharmacologically active dry powder;
step two, preparing pharmacological acid particles by using the water-soluble pharmacological active dry powder obtained in the step one;
step three, preparing pharmacological alkaline particles by using the alcohol-soluble pharmacological active dry powder obtained in the step one;
step four, uniformly mixing the pharmacological acidic particles obtained in the step two and the pharmacological alkaline particles obtained in the step three according to a ratio of 1:1 to obtain a finished product of the mouthwash effervescent granules.
3. The method for preparing effervescent mouthwash granules according to claim 2, wherein the first step comprises the following steps:
step 11, grinding 500g of dandelion root 15-20%, honeysuckle flower 15-20%, coix seed 10-20%, wrinkled gianthyssop herb 5-10%, folium artemisiae argyi 5-10%, centella asiatica 5-10% and pericarpium citri reticulatae 10-20% by weight into powder, frying the powder for 5min at 80 ℃, adding 50 ℃ warm water according to a ratio of 1:20, mixing the slurry and homogenizing;
step 12, adding 0.5-1% of cellulase, uniformly mixing, carrying out constant-temperature micro-magnetic stirring water bath reaction for 1h at 50-60 ℃ to dissolve out a large amount of bioactive substances, and centrifuging for 15min at 5000 rpm;
step 13, carrying out ultrafiltration on the supernatant obtained by centrifugation in the step 12 by 0.22 μm, filtering and concentrating by a nanofiltration membrane of three levels of 1000Da, 500Da and 150Da, collecting all filtrate, and freeze-drying to obtain water-soluble pharmacologically active dry powder;
and step 14, adding 80% ethanol solution with the volume 6 times that of the centrifugal slag obtained in the step 12, stirring and extracting the alcohol-soluble active substances, repeatedly extracting for two times, each time for 30min, centrifuging at 4000rpm for 15min to obtain supernatant, filtering by adopting a multi-stage fine filtering membrane, collecting all filtrate, and freeze-drying to obtain the alcohol-soluble pharmacological active dry powder.
4. The preparation method of the effervescent mouthwash granule as claimed in claim 3, wherein the second step specifically comprises the following steps:
and step 15, placing the water-soluble pharmacologically active dry powder obtained in the step 13 into a mortar, adding 150-200 g of allulose, 30-50g of mannitol, 30-50g of xylitol and 100-150 g of citric acid by an equivalent progressive method, uniformly mixing, adding a proper amount of 70% ethanol, mixing to prepare a soft material, sieving with a 20-mesh sieve, extruding and granulating, drying in an oven at 60 ℃ for 1 hour, sieving with the 20-mesh sieve for grading, and sieving with a 75-mesh sieve to remove fine powder to obtain pharmacologically acidic particles.
5. The preparation method of the effervescent mouthwash granule as claimed in claim 3, wherein the third step specifically comprises the following steps:
and step 16, placing the alcohol-soluble pharmacologically active dry powder obtained in the step 14 into a mortar, adding 150-200 g of allulose, 30-50g of mannitol, 30-50g of xylitol and sodium bicarbonate coated by polyethylene glycol 6000 according to an equivalent progressive method, uniformly mixing, adding a proper amount of 70% ethanol, mixing to prepare a soft material, sieving with a 20-mesh sieve, carrying out extrusion granulation, drying in an oven at 60 ℃ for 1 hour, sieving with the 20-mesh sieve for grading, and sieving with a 75-mesh sieve to remove fine powder, thus obtaining the pharmacologically alkaline particles.
6. The method for preparing effervescent mouthwash granules according to claim 5, wherein in step 16, the sodium bicarbonate coated with polyethylene glycol 6000 is prepared by the following method: heating 150-200 g of polyethylene glycol 6000 at 70-75 ℃ to melt, adding 130-200 g of sodium bicarbonate, mixing uniformly, cooling, crushing, and sieving with a 80-mesh sieve to obtain sodium bicarbonate coated with polyethylene glycol 6000 for later use.
7. A method of using the effervescent mouthwash granule according to claim 1, wherein a bag of mouthwash effervescent granules is poured into the oral cavity, dissolved by inhalation of half-mouth of pure water and repeatedly rinsed with the teeth and oral cavity for 3min before spitting out, and repeatedly rinsed with pure water several times.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010081946.0A CN111000734A (en) | 2020-02-06 | 2020-02-06 | Mouthwash effervescent granules and preparation method and use method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010081946.0A CN111000734A (en) | 2020-02-06 | 2020-02-06 | Mouthwash effervescent granules and preparation method and use method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111000734A true CN111000734A (en) | 2020-04-14 |
Family
ID=70120836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010081946.0A Withdrawn CN111000734A (en) | 2020-02-06 | 2020-02-06 | Mouthwash effervescent granules and preparation method and use method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111000734A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107372943A (en) * | 2017-09-20 | 2017-11-24 | 贵州健瑞安药业有限公司 | A kind of aid digestion pre- anti-halitosis health protection tea and its preparation method and application |
| CN108671148A (en) * | 2018-05-02 | 2018-10-19 | 佛山科学技术学院 | A kind of dendrobium candidum leaf effervescent and preparation method thereof |
| CN110250514A (en) * | 2019-07-01 | 2019-09-20 | 北京采瑞医药科技有限公司 | Health food of functions of removing chloasma and preparation method thereof |
-
2020
- 2020-02-06 CN CN202010081946.0A patent/CN111000734A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107372943A (en) * | 2017-09-20 | 2017-11-24 | 贵州健瑞安药业有限公司 | A kind of aid digestion pre- anti-halitosis health protection tea and its preparation method and application |
| CN108671148A (en) * | 2018-05-02 | 2018-10-19 | 佛山科学技术学院 | A kind of dendrobium candidum leaf effervescent and preparation method thereof |
| CN110250514A (en) * | 2019-07-01 | 2019-09-20 | 北京采瑞医药科技有限公司 | Health food of functions of removing chloasma and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 林余霖: "《本草纲目原色图谱800例》", 31 January 2020, 华龄出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102198065B (en) | Oral spray and preparation method thereof | |
| CN102177998B (en) | Throat-clearing health-care tea | |
| CN103893252A (en) | Composition capable of clearing heat from throat and relieving sore throat and preparation method and application thereof | |
| CN104666876A (en) | Traditional Chinese medicine for treating swollen sore throat | |
| CN105381019A (en) | Effervescent tablet with internal-fire clearing function and preparation method thereof | |
| CN107625828A (en) | A kind of health protection tea for auxiliary treatment chronic pharyngitis, preparation method and application | |
| CN107126476A (en) | Golden English lozenge of a kind of clearing heat, relieving sore-throat and preparation method thereof | |
| CN100382786C (en) | Bastard feverfew throat clearing drip pill and its preparation method | |
| CN106692755B (en) | Traditional Chinese medicine composition with hemostatic, anti-inflammatory and antibacterial functions and preparation method and application thereof | |
| CN102552683A (en) | Buccal tablet for removing oral discomfort, as well as preparation method and application thereof | |
| CN111000734A (en) | Mouthwash effervescent granules and preparation method and use method thereof | |
| CN109464540A (en) | A kind of alleviation oral cavity and the spray of throat discomfort and preparation method thereof | |
| CN113398185B (en) | Moistureproof five-flavor disinfection beverage granules and preparation method thereof | |
| CN101653552B (en) | Smoke-quitting alexeteric traditional Chinese medicine preparation and production method thereof | |
| CN100348215C (en) | Kaihoujian drip pill for treating throat disease and its preparation method | |
| CN113616721A (en) | Pharmaceutical composition for treating oral ulcer and preparation method and application thereof | |
| CN100455314C (en) | Medication for treating cough | |
| CN102327204A (en) | Oral care preparation and production method thereof | |
| JP2001122795A (en) | Prophylactic and therapeutic agent for infectious disease | |
| CN110507580A (en) | A kind of toothpaste of the ingredient containing trollflower and preparation method thereof | |
| CN112237594A (en) | Pharmaceutical composition, Pudilan buccal tablet and preparation method thereof | |
| CN100542517C (en) | Calculus bovis detoxifying dropping pill and preparation method thereof | |
| CN1055846C (en) | Pharynx and larynx health care products and production tech. | |
| CN104306692A (en) | Traditional Chinese medicine composition for treating swelling and aching of gum and preparation method | |
| CN114712436B (en) | Helicobacter pylori resistant compound and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20200414 |