CN110997919A - 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途 - Google Patents

双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途 Download PDF

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CN110997919A
CN110997919A CN201880049586.7A CN201880049586A CN110997919A CN 110997919 A CN110997919 A CN 110997919A CN 201880049586 A CN201880049586 A CN 201880049586A CN 110997919 A CN110997919 A CN 110997919A
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张鸿雁
高山
康代武
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Suzhou Ribo Life Science Co Ltd
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Abstract

提供了一种经修饰的双链寡核苷酸，正义链包含核苷酸序列1，反义链包含核苷酸序列2，核苷酸序列1和2长度都是19个核苷酸，按照5'末端到3'末端的方向，核苷酸序列1的第7，8、9位的核苷酸以及核苷酸序列2的第2、6、14、16位都是氟代修饰的核苷酸，其他位置的每个核苷酸独立地为非氟代修饰的核苷酸中的一种。还提供了包含该寡核苷酸的药物组合物、缀合物及其制药用途。

Description

PCT国内申请，说明书已公开。

Claims (70)

  1. PCT国内申请，权利要求书已公开。
CN201880049586.7A 2017-12-01 2018-11-29 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途 Active CN110997919B (zh)

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Application Number Priority Date Filing Date Title
CN2017112493569 2017-12-01
CN201711249345 2017-12-01
CN201711249356 2017-12-01
CN2017112493450 2017-12-01
CN201711249333 2017-12-01
CN2017112493338 2017-12-01
CN201711479058 2017-12-29
CN2017114790589 2017-12-29
CN201810951752 2018-08-21
CN2018109517524 2018-08-21
CN2018111653635 2018-09-30
CN201811165363 2018-09-30
PCT/CN2018/118212 WO2019105418A1 (zh) 2017-12-01 2018-11-29 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途

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US (2) US11492620B2 (zh)
EP (1) EP3719128A4 (zh)
JP (2) JP2021504415A (zh)
KR (1) KR20200091414A (zh)
CN (1) CN110997919B (zh)
AU (1) AU2018374219C1 (zh)
CA (1) CA3083968C (zh)
TW (1) TWI791696B (zh)
WO (1) WO2019105418A1 (zh)

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CN113795582A (zh) * 2019-05-24 2021-12-14 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
CN114632089A (zh) * 2020-12-16 2022-06-17 北京瑞博开拓医药科技有限公司 含酰基糖胺基团化合物在制备治疗新型冠状病毒肺炎药物中的应用及疾病的治疗方法
CN114686482A (zh) * 2020-12-29 2022-07-01 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途
WO2023284763A1 (zh) * 2021-07-16 2023-01-19 苏州瑞博生物技术股份有限公司 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途
WO2023116764A1 (zh) * 2021-12-23 2023-06-29 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及其用途
WO2023198201A1 (zh) * 2022-04-14 2023-10-19 苏州瑞博生物技术股份有限公司 适配体、缀合物与组合物及制备方法和用途

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WO2019105418A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途
US11660347B2 (en) 2017-12-01 2023-05-30 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate containing same, preparation method, and use thereof
CN116375774A (zh) 2017-12-29 2023-07-04 苏州瑞博生物技术股份有限公司 缀合物及其制备方法和用途
CN111655849B (zh) * 2018-08-21 2024-05-10 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的药物组合物和缀合物及其用途
US11896674B2 (en) 2018-09-30 2024-02-13 Suzhou Ribo Life Science Co., Ltd. SiRNA conjugate, preparation method therefor and use thereof
KR20210110839A (ko) * 2018-12-28 2021-09-09 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 핵산, 핵산을 함유하는 조성물 및 접합체, 이의 제조 방법 및 용도
EP4121533A1 (en) * 2020-03-06 2023-01-25 Aligos Therapeutics, Inc. Modified short interfering nucleic acid (sina) molecules and uses thereof
AU2022304946A1 (en) * 2021-07-02 2024-02-15 Tuojie Biotech (Shanghai) Co., Ltd. Nucleic acid ligand and conjugate thereof, and preparation method therefor and use thereof
AU2022309416A1 (en) 2021-07-16 2024-02-01 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate containing same, and preparation method and use
WO2023198202A1 (zh) * 2022-04-14 2023-10-19 苏州瑞博生物技术股份有限公司 缀合物与组合物及制备方法和用途
WO2024002093A1 (zh) * 2022-06-27 2024-01-04 大睿生物医药科技(上海)有限公司 抑制载脂蛋白C3表达的siRNA

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