CN110917057A - Compound preservative agent, preparation method thereof and application thereof in cosmetics - Google Patents
Compound preservative agent, preparation method thereof and application thereof in cosmetics Download PDFInfo
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- CN110917057A CN110917057A CN201911394196.6A CN201911394196A CN110917057A CN 110917057 A CN110917057 A CN 110917057A CN 201911394196 A CN201911394196 A CN 201911394196A CN 110917057 A CN110917057 A CN 110917057A
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- preservative agent
- compound preservative
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- cosmetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The compound preservative agent is prepared by compounding 5-20% of p-hydroxyacetophenone, 5-20% of chlorphenesin, 5-20% of phenoxyethanol and 5-10% of caprylyl hydroximic acid, and dissolving the compound preservative agent in 30-80% of C3-C8 dihydric alcohol to prepare the liquid compound preservative agent, so that the liquid compound preservative agent can be applied to the preparation of cosmetics and used as a cosmetic formula, experiments show that the four preservatives can generate a synergistic effect after being compounded, compared with the single use of any one of the preservatives, when the compound preservative agent is applied in the cosmetic formula, the compound preservative agent has a better preservative effect under a smaller dose, and the preservative agent can achieve a better preservative effect only by using a larger dose, and because the compound preservative agent has a small using amount, the generated irritation is negligible, is safer when used in cosmetics.
Description
Technical Field
The invention relates to the field of preservatives, and particularly relates to a compound preservative agent, a preparation method thereof and application thereof in cosmetics.
Background
In recent years, with the development of industrial technology and the improvement of living standard, cosmetics have been developed as necessities in human life, and safety of use of cosmetics is important for the purpose of spreading the cosmetics to the skin, hair, nails, lips, teeth, etc. on the surface of the human body. Since most products in cosmetics circulate at normal temperature and are continuously exposed to microorganisms after being unsealed, it is important to use a suitable preservative having an excellent bactericidal effect in order to maintain the quality of the cosmetics.
As a preservative, natural preservatives have little effect on microbial sterilization and thus are not widely used in the cosmetic industry, and if used in excess in order to obtain a microbial sterilization effect, the stability of a cosmetic formulation is deteriorated and toxicity is generated. Therefore, it is an urgent problem to select a preservative having a low dosage and an excellent bactericidal effect.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: the compound preservative agent with small dosage and remarkable sterilization effect is prepared, so that the compound preservative agent can be applied to the formula of cosmetics.
In order to solve the technical problems, the invention adopts the technical scheme that:
the invention provides a compound preservative agent, which comprises the following components in percentage by weight: 5-20% of p-hydroxyacetophenone, 5-20% of chlorphenesin, 5-20% of phenoxyethanol, 5-10% of caprylyl hydroxamic acid and 30-80% of C3-C8 dihydric alcohol.
The preparation method of the compound preservative agent comprises the steps of fully and uniformly stirring the p-hydroxyacetophenone, the chlorphenesin, the phenoxyethanol, the caprylyl hydroxamic acid and the dihydric alcohol of C3-C8 at the temperature of 45-75 ℃ to prepare the compound preservative agent.
The compound preservative agent can be used for preparing cosmetics.
The invention also relates to a cosmetic, which contains the compound preservative agent.
The invention has the beneficial effects that: the compound preservative agent is prepared by compounding 5-20% of p-hydroxyacetophenone, 5-20% of chlorphenesin, 5-20% of phenoxyethanol and 5-10% of caprylyl hydroximic acid, and dissolving the compound preservative agent in 30-80% of C3-C8 dihydric alcohol to prepare the liquid compound preservative agent, so that the liquid compound preservative agent can be applied to the preparation of cosmetics and used as a cosmetic formula, experiments show that the four preservatives can generate a synergistic effect after being compounded, compared with the single use of any one of the preservatives, when the compound preservative agent is applied in the cosmetic formula, the compound preservative agent has a better preservative effect under a smaller dose, and the preservative agent can achieve a better preservative effect only by using a larger dose, and because the compound preservative agent has a small using amount, the generated irritation is negligible, is safer when used in cosmetics.
Detailed Description
In order to explain the technical content, the objects and the effects of the present invention in detail, the following description will be given with reference to the embodiments.
The most key concept of the invention is as follows: 5-20% of p-hydroxyacetophenone, 5-20% of chlorphenesin, 5-20% of phenoxyethanol and 5-10% of caprylyl hydroxamic acid are compounded and dissolved in 30-80% of C3-C8 dihydric alcohol to prepare a liquid compound preservative agent, so that the liquid compound preservative agent can be applied to preparation of cosmetics and used as a cosmetic formula and has the advantages of small irritation and good preservative effect.
The invention provides a compound preservative agent, which comprises the following components in percentage by weight: 5-20% of p-hydroxyacetophenone, 5-20% of chlorphenesin, 5-20% of phenoxyethanol, 5-10% of caprylyl hydroxamic acid and 30-80% of C3-C8 dihydric alcohol.
Preferably, in the compound preservative agent, the dihydric alcohol of C3-C8 is at least one selected from 1, 2-propylene glycol and 1, 2-hexylene glycol.
The preparation method of the compound preservative agent comprises the steps of fully and uniformly stirring the p-hydroxyacetophenone, the chlorphenesin, the phenoxyethanol, the caprylyl hydroxamic acid and the dihydric alcohol of C3-C8 at the temperature of 45-75 ℃ to prepare the compound preservative agent.
The compound preservative agent can be used for preparing cosmetics.
The invention also relates to a cosmetic, which contains the compound preservative agent.
Preferably, the amount of the compound preservative agent in the cosmetic is 0.1-5.0 wt%.
Preferably, the amount of the compound preservative agent in the cosmetic is 0.5-2.0 wt%.
Example 1
According to weight percentage, 5 percent of p-hydroxyacetophenone, 5 percent of chlorphenesin, 5 percent of phenoxyethanol, 5 percent of caprylyl hydroximic acid and 80 percent of 1,2 propylene glycol are prepared.
Stirring p-hydroxyacetophenone, chlorphenesin, phenoxyethanol, caprylhydroxamic acid and 1, 2-propylene glycol at 45 ℃ until the p-hydroxyacetophenone, chlorphenesin, phenoxyethanol, caprylhydroxamic acid and 1, 2-propylene glycol are completely dissolved, cooling to room temperature, and finally preparing the compound preservative agent.
Example 2
According to weight percentage, 10 percent of p-hydroxyacetophenone, 20 percent of chlorphenesin, 20 percent of phenoxyethanol, 20 percent of caprylyl hydroximic acid and 30 percent of 1, 2-propylene glycol are prepared.
Stirring p-hydroxyacetophenone, chlorphenesin, phenoxyethanol, caprylhydroxamic acid and 1, 2-propylene glycol at 75 ℃ until the p-hydroxyacetophenone, chlorphenesin, phenoxyethanol, caprylhydroxamic acid and 1, 2-propylene glycol are completely dissolved, cooling to room temperature, and finally preparing the compound preservative agent.
Example 3
According to weight percentage, 20 percent of p-hydroxyacetophenone, 10 percent of chlorphenesin, 20 percent of phenoxyethanol, 20 percent of caprylyl hydroximic acid and 30 percent of 1, 2-hexanediol are prepared.
Stirring p-hydroxyacetophenone, chlorphenesin, phenoxyethanol, caprylhydroxamic acid and 1, 2-hexanediol at 60 ℃ until the materials are completely dissolved, and cooling to room temperature to finally prepare the compound preservative agent.
Example 4
According to weight percentage, 10 percent of p-hydroxyacetophenone, 10 percent of chlorphenesin, 10 percent of phenoxyethanol, 15 percent of caprylyl hydroximic acid, 30 percent of 1, 2-propylene glycol and 25 percent of 1, 2-hexanediol are prepared.
Stirring p-hydroxyacetophenone, chlorphenesin, phenoxyethanol, caprylhydroxamic acid, 1, 2-propylene glycol and 1, 2-hexanediol at the temperature of 60 ℃ until the materials are completely dissolved, cooling to room temperature, and finally preparing the compound preservative agent.
Comparative example 1
According to the weight percentage, 20 percent of p-hydroxyacetophenone and 80 percent of 1, 2-propylene glycol are prepared.
Stirring p-hydroxyacetophenone and 1, 2-propylene glycol at 45 ℃ until completely dissolved, and cooling to room temperature to finally prepare the preservative agent.
Comparative example 2
According to the weight percentage, 20 percent of chlorphenesin and 80 percent of 1, 2-propylene glycol are prepared.
Stirring chlorphenesin and 1, 2-propylene glycol at 45 ℃ until completely dissolved, and cooling to room temperature to obtain the preservative agent.
Comparative example 3
According to the weight percentage, 20 percent of phenoxyethanol and 80 percent of 1, 2-propylene glycol are prepared.
Stirring phenoxyethanol and 1, 2-propylene glycol at 45 deg.C until completely dissolved, cooling to room temperature, and making into antiseptic agent.
Comparative example 4
20 percent of caprylyl hydroximic acid and 80 percent of 1, 2-propylene glycol are prepared according to weight percentage.
Stirring caprylyl hydroximic acid and 1, 2-propylene glycol at 45 ℃ until completely dissolved, and cooling to room temperature to finally prepare the preservative agent.
Application example 1
The compound preservative agent prepared in the examples 1-4 is used in skin care emulsion, and the formula is shown in the table 1;
TABLE 1
1. Putting 1,2, 3, 4 and 5 of the phase A component into an emulsifying pot, heating to 80 ℃, and stirring for 1 hour under the condition of heat preservation;
2. cooling water is introduced into the emulsifying pot, the temperature of the system is reduced to 55 ℃, and the phase B and the phase C are added;
3. cooling to 45 ℃, adding the phase D into an emulsifying pot, and homogenizing for 1 minute;
4. cooling to 35 deg.C to complete the preparation process.
The formulation, preparation and use of the blank skin care emulsion were similar to those of example 1 except that phase D was not added to the emulsion.
Comparative skin care emulsions were formulated, prepared, and used in similar manner as in application example 1, except that phase D in the emulsion was the preservative agent prepared in comparative examples 1-4.
Examples 1 to 4 and comparative examples 1 to 4 were evaluated for corrosion prevention efficacy. According to the United states Pharmacopeia USP35<51>Antimicrobial efficacy test, the preservative challenge test was performed. The strains tested were Staphylococcus aureus (ATCC6538), Pseudomonas aeruginosa (ATCC9027), Aspergillus niger (ATCCL6404), Escherichia coli (ATCC25922), Candida albicans (ATCC10231), and the initial inoculum size was 4.0X 106CFU/g or 2.0X 106CFU/g。
The emulsion is averagely divided into 9 parts, 1 part of blank emulsion is not added with any preservative, the preservative composition prepared in comparative examples 1-4 is added into the corresponding 4 parts of blank skin care emulsion, and then the compound preservative agent prepared in the compound examples 1-4 is correspondingly added into the other 4 parts of blank skin care emulsion.
Culturing the 9 bacteria-added emulsion samples under the same conditions for 28 days, and detecting the bacteria content every 7 days, wherein the results are shown in table 2;
TABLE 2
It can be seen from Table 2 that the skin care emulsions prepared using the antiseptic compositions prepared in examples 1 to 4 as component D reduced the number of bacteria and fungi to less than 10cfu/ml in 7 days, whereas the cosmetic emulsions prepared using the preservatives prepared in comparative examples 1 to 4 as component D failed to reduce the number of bacteria and fungi to less than 10cfu/ml in 7 days, and required 14 days to reduce the number of bacteria and fungi to less than 10cfu/ml, the amount of the antiseptic composition added in the component D of example 1 was the same as the amount of the antiseptic added in the components D of comparative examples 1,2, 3 and 4, and was 20% of the total amount of the components D, and the percentages of the components D of example 1 and 1,2, 3 and 4 were 0.2% in the total formulation of the emulsion cosmetic, namely, the total amount of the preservatives added in the example 1 is the same as that added in the comparative examples 1,2, 3 and 4, but the preservative effect of the example 1 is better than that of the comparative examples 1,2, 3 and 4, namely, the preservative composition adopted by the invention has better preservative effect than that of one of p-hydroxyacetophenone, chlorphenesin, phenoxyethanol and caprylhydroxamic acid which are singly used at lower dosage.
In conclusion, the compound preservative agent related by the invention is prepared by compounding 5-20% of p-hydroxyacetophenone, 5-20% of chlorphenesin, 5-20% of phenoxyethanol and 5-10% of caprylyl hydroxamic acid, and dissolving the compound preservative agent in 30-80% of C3-C8 dihydric alcohol to prepare a liquid compound preservative agent, so that the liquid compound preservative agent can be applied to the preparation of cosmetics and used as a cosmetic formula, experiments show that the four preservatives can generate a synergistic effect after being compounded, compared with the single use of any one of the preservatives, when the preservative agent is applied in the cosmetic formula, the compounded preservative agent has a better preservative effect under a smaller dosage, and the preservative agent needs a larger dosage to achieve a better preservative effect when being used alone, and the generated irritation is negligible due to the small dosage of the compound preservative agent, is safer when used in cosmetics.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent modifications made by the present invention in the specification or directly or indirectly applied to the related technical field are included in the scope of the present invention.
Claims (7)
1. A compound preservative agent is characterized by comprising the following components in percentage by weight: 5-20% of p-hydroxyacetophenone, 5-20% of chlorphenesin, 5-20% of phenoxyethanol, 5-10% of caprylyl hydroxamic acid and 30-80% of C3-C8 dihydric alcohol.
2. The combination preservative agent according to claim 1, wherein the C3-C8 diol is at least one selected from the group consisting of 1, 2-propanediol and 1, 2-hexanediol.
3. The preparation method of the compound preservative agent as claimed in claim 1 or 2, wherein the p-hydroxyacetophenone, chlorphenesin, phenoxyethanol, caprylhydroxamic acid and the C3-C8 diol are fully and uniformly stirred at 45-75 ℃ to prepare the compound preservative agent.
4. Use of a combination preservative agent according to any of claims 1-2 for the preparation of a cosmetic product.
5. A cosmetic product comprising a built preservative agent according to any of claims 1-2.
6. The cosmetic of claim 5, wherein said compounded preservative agent is present in said cosmetic in an amount of from 0.1 to 5.0% by weight.
7. The cosmetic of claim 5, wherein the amount of the built preservative agent in the cosmetic is 0.5-2.0 wt%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911394196.6A CN110917057A (en) | 2019-12-30 | 2019-12-30 | Compound preservative agent, preparation method thereof and application thereof in cosmetics |
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| CN201911394196.6A CN110917057A (en) | 2019-12-30 | 2019-12-30 | Compound preservative agent, preparation method thereof and application thereof in cosmetics |
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| CN110917057A true CN110917057A (en) | 2020-03-27 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113679642A (en) * | 2021-10-13 | 2021-11-23 | 益盛汉参化妆品有限公司 | Composition containing p-hydroxyacetophenone and preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109296A (en) * | 2016-06-30 | 2016-11-16 | 彭燕辉 | A kind of moisturizing essence lotion and preparation method thereof |
| CN106726658A (en) * | 2017-03-13 | 2017-05-31 | 福州美乐莲生物科技有限公司 | Preservative of a kind of hydroximic acid containing decoyl and parahydroxyacet-ophenone and its preparation method and application and the cosmetics containing the preservative |
| DE102015225005A1 (en) * | 2015-12-11 | 2017-06-14 | Henkel Ag & Co. Kgaa | Emulsions containing at least one special preservative combination |
| DE102015225003A1 (en) * | 2015-12-11 | 2017-06-14 | Henkel Ag & Co. Kgaa | Emulsions containing at least three different preservatives |
| CN108567579A (en) * | 2018-07-27 | 2018-09-25 | 广州世航生物科技有限公司 | Anticorrosive composite and its application |
-
2019
- 2019-12-30 CN CN201911394196.6A patent/CN110917057A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102015225005A1 (en) * | 2015-12-11 | 2017-06-14 | Henkel Ag & Co. Kgaa | Emulsions containing at least one special preservative combination |
| DE102015225003A1 (en) * | 2015-12-11 | 2017-06-14 | Henkel Ag & Co. Kgaa | Emulsions containing at least three different preservatives |
| CN106109296A (en) * | 2016-06-30 | 2016-11-16 | 彭燕辉 | A kind of moisturizing essence lotion and preparation method thereof |
| CN106726658A (en) * | 2017-03-13 | 2017-05-31 | 福州美乐莲生物科技有限公司 | Preservative of a kind of hydroximic acid containing decoyl and parahydroxyacet-ophenone and its preparation method and application and the cosmetics containing the preservative |
| CN108567579A (en) * | 2018-07-27 | 2018-09-25 | 广州世航生物科技有限公司 | Anticorrosive composite and its application |
Non-Patent Citations (3)
| Title |
|---|
| 王宏图等: "《皮肤科药物手册》", 31 May 2004 * |
| 裘炳毅，高志红编: "《现代化妆品科学与技术 上》", 31 March 2016, 中国轻工业出版社 * |
| 魏太星等: "《医生专用药物手册》", 31 January 2015 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113679642A (en) * | 2021-10-13 | 2021-11-23 | 益盛汉参化妆品有限公司 | Composition containing p-hydroxyacetophenone and preparation method and application thereof |
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Application publication date: 20200327 |