CN110914277A - 咪唑并[1,2-b]嘧啶并[4,5-d]哒嗪-5(6H)-酮类化合物及其应用 - Google Patents
咪唑并[1,2-b]嘧啶并[4,5-d]哒嗪-5(6H)-酮类化合物及其应用 Download PDFInfo
- Publication number
- CN110914277A CN110914277A CN201880046450.0A CN201880046450A CN110914277A CN 110914277 A CN110914277 A CN 110914277A CN 201880046450 A CN201880046450 A CN 201880046450A CN 110914277 A CN110914277 A CN 110914277A
- Authority
- CN
- China
- Prior art keywords
- pyrimido
- pyridazin
- amino
- phenyl
- imidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
Abstract
本发明提供咪唑并[1,2‑b]嘧啶并[4,5‑d]哒嗪‑5(6H)‑酮类化合物。具体而言，本发明提供式I的化合物，或其可药用盐或前药：
其中A，R1‑R5为本文所定义。式I的化合物是Wee1激酶抑制剂。因此，本发明的化合物可用于治疗由Weel活性异常而导致的疾病。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017105561487 | 2017-07-10 | ||
| CN201710556148 | 2017-07-10 | ||
| PCT/CN2018/095080 WO2019011228A1 (zh) | 2017-07-10 | 2018-07-10 | 咪唑并[1,2-b]嘧啶并[4,5-d]哒嗪-5(6H)-酮类化合物及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110914277A true CN110914277A (zh) | 2020-03-24 |
| CN110914277B CN110914277B (zh) | 2022-08-09 |
Family
ID=65001106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880046450.0A Active CN110914277B (zh) | 2017-07-10 | 2018-07-10 | 咪唑并[1,2-b]嘧啶并[4,5-d]哒嗪-5(6H)-酮类化合物及其应用 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US11345710B2 (zh) |
| CN (1) | CN110914277B (zh) |
| WO (1) | WO2019011228A1 (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11299493B2 (en) | 2017-10-09 | 2022-04-12 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| WO2019074981A1 (en) | 2017-10-09 | 2019-04-18 | GiraFpharma LLC | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
| WO2020210375A1 (en) | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| US20240010655A1 (en) * | 2019-10-16 | 2024-01-11 | Impact Therapeutics (Shanghai), Inc | Dihydroimidazo pyrimido pyrimidinone compound |
| CN117202908A (zh) * | 2021-03-10 | 2023-12-08 | 上海瑛派药业有限公司 | Wee1激酶抑制剂在治疗癌症疾病中的应用 |
| WO2023093840A1 (en) * | 2021-11-26 | 2023-06-01 | Impact Therapeutics (Shanghai) , Inc | Use of wee1 kinase inhibitors in the treatment of cancer |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030114432A1 (en) * | 2001-09-19 | 2003-06-19 | Michael Clare | Substituted pyrazolyl compounds for the treatment of inflammation |
| US20050070554A1 (en) * | 2003-08-27 | 2005-03-31 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| US20130023523A1 (en) * | 2011-07-19 | 2013-01-24 | Abbott Laboratories | Pyridazino[4,5-d]pyrimidin-5(6h)-one inhibitors of kinases |
| CN103703005A (zh) * | 2011-02-28 | 2014-04-02 | 艾伯维公司 | 激酶的三环抑制剂 |
| CN105829315A (zh) * | 2013-12-19 | 2016-08-03 | 阿尔麦克探索有限公司 | 可用作Wee-1激酶抑制剂的嘧啶并嘧啶酮类 |
-
2018
- 2018-07-10 WO PCT/CN2018/095080 patent/WO2019011228A1/zh active Application Filing
- 2018-07-10 US US16/629,185 patent/US11345710B2/en active Active
- 2018-07-10 CN CN201880046450.0A patent/CN110914277B/zh active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030114432A1 (en) * | 2001-09-19 | 2003-06-19 | Michael Clare | Substituted pyrazolyl compounds for the treatment of inflammation |
| US20050070554A1 (en) * | 2003-08-27 | 2005-03-31 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| CN103703005A (zh) * | 2011-02-28 | 2014-04-02 | 艾伯维公司 | 激酶的三环抑制剂 |
| US20130023523A1 (en) * | 2011-07-19 | 2013-01-24 | Abbott Laboratories | Pyridazino[4,5-d]pyrimidin-5(6h)-one inhibitors of kinases |
| CN105829315A (zh) * | 2013-12-19 | 2016-08-03 | 阿尔麦克探索有限公司 | 可用作Wee-1激酶抑制剂的嘧啶并嘧啶酮类 |
Non-Patent Citations (1)
| Title |
|---|
| 胡金龙等: "Weel蛋白激酶的研究及进展", 《研究进展》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110914277B (zh) | 2022-08-09 |
| US11345710B2 (en) | 2022-05-31 |
| US20200131192A1 (en) | 2020-04-30 |
| WO2019011228A1 (zh) | 2019-01-17 |
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