CN1108308C - 一种匙羹藤提取物及其制备方法和用途 - Google Patents
一种匙羹藤提取物及其制备方法和用途 Download PDFInfo
- Publication number
- CN1108308C CN1108308C CN99103588A CN99103588A CN1108308C CN 1108308 C CN1108308 C CN 1108308C CN 99103588 A CN99103588 A CN 99103588A CN 99103588 A CN99103588 A CN 99103588A CN 1108308 C CN1108308 C CN 1108308C
- Authority
- CN
- China
- Prior art keywords
- extract
- gymnema sylvestre
- time
- extraction
- triterpenoid saponin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000000284 extract Substances 0.000 title claims description 62
- 241000208253 Gymnema sylvestre Species 0.000 title claims description 43
- 238000000605 extraction Methods 0.000 claims abstract description 28
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims abstract description 9
- 150000008130 triterpenoid saponins Chemical class 0.000 claims abstract description 9
- 239000003814 drug Substances 0.000 claims abstract description 4
- 229930182486 flavonoid glycoside Natural products 0.000 claims abstract description 3
- 150000007955 flavonoid glycosides Chemical class 0.000 claims abstract description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- -1 triterpenoid saponin compounds Chemical class 0.000 claims description 8
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 6
- 239000000469 ethanolic extract Substances 0.000 claims description 6
- 230000002218 hypoglycaemic effect Effects 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 5
- 235000019634 flavors Nutrition 0.000 claims description 5
- 235000012054 meals Nutrition 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 241000240378 Gymnema latifolium Species 0.000 claims description 4
- 230000000702 anti-platelet effect Effects 0.000 claims description 4
- 239000003146 anticoagulant agent Substances 0.000 claims description 4
- VEVZSMAEJFVWIL-UHFFFAOYSA-O cyanidin cation Chemical compound [O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC=C(O)C(O)=C1 VEVZSMAEJFVWIL-UHFFFAOYSA-O 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 235000007336 cyanidin Nutrition 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 abstract description 11
- 239000008280 blood Substances 0.000 abstract description 11
- 150000002632 lipids Chemical class 0.000 abstract description 6
- 239000000203 mixture Substances 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 2
- XBZYWSMVVKYHQN-MYPRUECHSA-N (4as,6as,6br,8ar,9r,10s,12ar,12br,14bs)-10-hydroxy-2,2,6a,6b,9,12a-hexamethyl-9-[(sulfooxy)methyl]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid Chemical compound C1C[C@H](O)[C@@](C)(COS(O)(=O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C XBZYWSMVVKYHQN-MYPRUECHSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 14
- 241000700159 Rattus Species 0.000 description 13
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 210000002966 serum Anatomy 0.000 description 6
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 239000000741 silica gel Substances 0.000 description 5
- 229910002027 silica gel Inorganic materials 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 description 4
- 229960001214 clofibrate Drugs 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 235000019359 magnesium stearate Nutrition 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 3
- 208000031226 Hyperlipidaemia Diseases 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 235000021590 normal diet Nutrition 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- ICFJFFQQTFMIBG-UHFFFAOYSA-N phenformin Chemical compound NC(=N)NC(=N)NCCC1=CC=CC=C1 ICFJFFQQTFMIBG-UHFFFAOYSA-N 0.000 description 3
- 229960003243 phenformin Drugs 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 241000037488 Coccoloba pubescens Species 0.000 description 2
- 241000208251 Gymnema Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229930183009 gymnemic acid Natural products 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 210000004623 platelet-rich plasma Anatomy 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
- 241000208327 Apocynaceae Species 0.000 description 1
- 239000004380 Cholic acid Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 101001046633 Homo sapiens Junctional adhesion molecule A Proteins 0.000 description 1
- 102100022304 Junctional adhesion molecule A Human genes 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000019416 cholic acid Nutrition 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 229960002471 cholic acid Drugs 0.000 description 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- PMRYVIKBURPHAH-UHFFFAOYSA-N methimazole Chemical compound CN1C=CNC1=S PMRYVIKBURPHAH-UHFFFAOYSA-N 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 210000004279 orbit Anatomy 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229960002178 thiamazole Drugs 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- KWEUUBDPVVHQAL-MSQVLRTGSA-K trisodium;[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O KWEUUBDPVVHQAL-MSQVLRTGSA-K 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组别 | 剂量(mg/kg) | 血糖值(mmol/L) | ||
30min | 60min | 120min | ||
正常组 | 3.56±0.64 | 4.12±0.72 | 3.76±0.69 | |
对照组 | 6.58±0.87ΔΔ | 5.93±1.27ΔΔ | 4.54±1.37 | |
本发明匙羹藤提取物 | 50 | 6.03±0.86 | 6.42±0.78 | 4.26±1.03 |
100 | 5.12±1.29* | 5.77±1.09 | 4.53±0.94 | |
200 | 4.43±0.72** | 4.73±0.83* | 4.07±0.70 | |
降糖灵 | 100 | 4.24±0.87** | 4.74±0.90* | 4.79±1.03 |
组别 | 剂量(mg/kg) | 甘油三酯(mmol/L) | 总胆固醇(mmol/L) | ||
给药前 | 给药后 | 给药前 | 给药后 | ||
正常组 | 1.02±0.22 | 1.04±0.15 | 2.43±0.41 | 1.99±0.47 | |
对照组 | 2.64±0.82 | 3.04±0.93 | 4.10±0.51ΔΔ | 4.77±0.63ΔΔ | |
本发明匙羹藤提取物 | 50 | 2.72±0.61 | 2.41±0.44 | 4.29±0.60 | 3.92±0.58** |
100 | 2.54±0.90 | 1.75±0.53** | 4.02±0.59 | 2.94±0.66** | |
200 | 2.72±0.76 | 1.37±0.40** | 4.18±0.61 | 2.31±0.74** | |
安妥明 | 100 | 2.51±0.77 | 2.72±0.74 | 4.33±0.51 | 2.15±0.76** |
组别 | 终浓度(ug/ml) | 最大聚集率(%) | 抑制率(%) |
对照组 | 47.9±5.2 | ||
本发明匙羹藤提取物 | 250 | 43.6±7.0 | 9.0 |
500 | 35.9±4.5** | 25.1 | |
1000 | 27.8±4.8** | 42.0 | |
阿斯匹林 | 250 | 23.7±6.0** | 50.3 |
Claims (11)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN99103588A CN1108308C (zh) | 1999-04-05 | 1999-04-05 | 一种匙羹藤提取物及其制备方法和用途 |
US09/913,322 US6833443B1 (en) | 1999-02-11 | 2000-01-21 | Gymnemic acid derivatives, process for the preparation thereof and use thereof as medicine |
DE60004353T DE60004353T2 (de) | 1999-02-11 | 2000-01-21 | Derivate der gymnemischen säure, verfahren zu ihrer herstellung und ihre verwendung als medikamente |
CA2362864A CA2362864C (en) | 1999-02-11 | 2000-01-21 | New gymnemic acid derivatives, their preparation, pharmaceutical composition containing them and their medical use |
PCT/CN2000/000010 WO2000047594A1 (fr) | 1999-02-11 | 2000-01-21 | Nouveau derives d'acide gymnemique, leur procede de preparation et leur application comme medicaments |
KR1020017010217A KR100625222B1 (ko) | 1999-02-11 | 2000-01-21 | 신규 짐넴산 유도체, 그 제조 방법, 및 그의 약학적 용도 |
AU20909/00A AU2090900A (en) | 1999-02-11 | 2000-01-21 | Novel gymnemic acid derivatives, process for the preparation thereof and use thereof as medicine |
JP2000598513A JP4903309B2 (ja) | 1999-02-11 | 2000-01-21 | 新規ギムネマ酸誘導体、その製造、それらを含む医薬組成物、およびそれらの医薬的使用 |
EP00901035A EP1176149B1 (en) | 1999-02-11 | 2000-01-21 | Novel gymnemic acid derivatives, process for the preparation thereof and use thereof as medicine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN99103588A CN1108308C (zh) | 1999-04-05 | 1999-04-05 | 一种匙羹藤提取物及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1268515A CN1268515A (zh) | 2000-10-04 |
CN1108308C true CN1108308C (zh) | 2003-05-14 |
Family
ID=5271355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN99103588A Expired - Fee Related CN1108308C (zh) | 1999-02-11 | 1999-04-05 | 一种匙羹藤提取物及其制备方法和用途 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1108308C (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100335073C (zh) * | 2005-08-19 | 2007-09-05 | 浙江大学 | 木鳖子含三萜皂甙成分提取物的制备方法 |
CN100424092C (zh) * | 2005-11-18 | 2008-10-08 | 华南理工大学 | 三萜烯糖苷天然甜味抑制剂的提取方法 |
CN100455298C (zh) * | 2006-09-15 | 2009-01-28 | 江苏大学 | 一种匙羹藤总皂甙包合物及其制备方法 |
CN106306817A (zh) * | 2015-07-08 | 2017-01-11 | 李凤军 | 一种防治糖尿病的保健食品组合物 |
CN106474281A (zh) * | 2015-10-16 | 2017-03-08 | 赫博美国际有限公司 | 一种治疗ⅱ型糖尿病及其并发症的中药组合物及其制剂和制法 |
CN106518950B (zh) * | 2016-10-21 | 2018-10-30 | 广西中医药大学 | 香树脂醇桂皮酸酯提取物及其制备方法 |
CN108095054B (zh) * | 2017-12-19 | 2021-06-15 | 哈尔滨仑傲科技有限公司 | 一种减少膳食中糖分消化和吸收的植物性胶囊及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843909A (en) * | 1997-06-13 | 1998-12-01 | Kowa Chemical Industries Co., Ltd. | (3-β), 4-α, 16-β)-16, -23, 28-trihdroxyolean-12-ene-3-yl-β-D-glucopyranuronic acid derivatives, as glucose absorption inhibiting agents |
-
1999
- 1999-04-05 CN CN99103588A patent/CN1108308C/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843909A (en) * | 1997-06-13 | 1998-12-01 | Kowa Chemical Industries Co., Ltd. | (3-β), 4-α, 16-β)-16, -23, 28-trihdroxyolean-12-ene-3-yl-β-D-glucopyranuronic acid derivatives, as glucose absorption inhibiting agents |
Also Published As
Publication number | Publication date |
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CN1268515A (zh) | 2000-10-04 |
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Owner name: GUILIN JIQI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SHANDONG GREEN LEAF PHARMACEUTICAL CO., LTD. Effective date: 20010928 |
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Effective date of registration: 20010928 Address after: 541004 No. 55 Yucai Road, Qixing District, Guilin, Guangxi Applicant after: Guilin Jiqi Pharmaceutical Industry Co., Ltd. Address before: 264003, No. 9, Po Yuen Road, Laishan District, Shandong, Yantai Applicant before: Luye Pharmaceutical Co., Ltd., Shandong |
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Owner name: GUILIN JIQI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: GUILIN JIQI PHARMACEUTICAL INDUSTRY CO., LTD. Effective date: 20110907 |
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Effective date of registration: 20110907 Address after: Huan Cheng Nan Qixing District, Guilin city 541004 the Guangxi Zhuang Autonomous Region Road No. 36 Building 2 water treatment plant Patentee after: Guilin Ji Qi Pharmaceutical Co., Ltd. Address before: 541004 No. 55 Yucai Road, Qixing District, Guilin, Guangxi Patentee before: Guilin Jiqi Pharmaceutical Industry Co., Ltd. |
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Addressee: Feng Wenxin Document name: Notification of Passing Examination on Formalities |
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