CN110801459A - 一种灰指甲膏的制备方法 - Google Patents

一种灰指甲膏的制备方法 Download PDF

Info

Publication number
CN110801459A
CN110801459A CN201810886995.4A CN201810886995A CN110801459A CN 110801459 A CN110801459 A CN 110801459A CN 201810886995 A CN201810886995 A CN 201810886995A CN 110801459 A CN110801459 A CN 110801459A
Authority
CN
China
Prior art keywords
mixing
onychomycosis
percent
ointment
onychomycosis ointment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810886995.4A
Other languages
English (en)
Inventor
杨润田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201810886995.4A priority Critical patent/CN110801459A/zh
Publication of CN110801459A publication Critical patent/CN110801459A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

本发明公开了一种灰指甲膏的制备方法，它是将凤仙花5％～10％，尿素10％～40％，凡士林5％～25％，雷锁辛5％～10％，土槿皮酊10％～30％，乳酸10％～30％，水杨酸8％～30％粉碎混合制成灰指甲膏，该方法配方精炼，工艺简单成本低，可获得使用方便的灰指甲膏，并能在短期内除掉病甲，又无毒副作用。

Description

一种灰指甲膏的制备方法
技术领域
本发明是一种灰指甲膏的制备方法，属于医药制备技术领域。
背景技术
灰指甲是一种常见多发病，尤其是在气候潮湿的我国西南地区，如四川、云南、广东、广西等地，灰指甲病病虽小，但却给人们工作、生活、社交带来很多不便，造成身心痛苦。八十年代末，人们对灰指甲主要采用内服灰黄霉素和封包拨甲两种方法治疗，内服灰黄霉素对大多数患者都有不良反应和副作用，封包拨甲对患者极为不利。九十年代初期，CN1063820A的中国专利申请公开报导了一种灰指甲溶解膏的制造方法，其配方由黄丹等九味矿物性中药，白凤仙花等七味植物性中药，邻羟基苯甲酸西药及其它十多种物质组成，配方繁多，制备复杂。
发明内容
本发明的目的是研制一种配方精炼，工艺简单成本低，使用方便的灰指甲膏，使其在短期内除掉病甲，又无毒副作用。
本发明地目的是通过下述方案来实现的(以下含量均为重量百分数)。
本发明的灰指甲膏由凤仙花5％～10％，尿素10％～40％，凡士林5％～25％，雷锁辛5％～10％，土槿皮酊10％～30％，乳酸10％～30％，水杨酸8％～30％混合而成，其中的粗颗粒原料需干燥粉碎后再混合。
上述方案中，还可加入苦参和/或大蒜油，加入量均为5％～8％。
上述方案中，较好是将凤仙花，苦参粉碎混合后加入大蒜油混匀得Ⅰ，将尿素、雷锁辛、水杨酸粉碎混合得Ⅱ，将土槿皮酊、乳酸混合得Ⅲ，将Ⅰ加入Ⅱ混匀再加入Ⅲ中混合得Ⅳ，将凡士林加热至40～60℃加入Ⅳ中混匀包装即可得产品灰指甲膏。
上述方案中Ⅰ的粒径较佳是控制在100～120目范围内。
上述方案中，还可加入其他添加剂。
上述方法制备的灰指甲膏还可在治疗灰指甲以外的其他医药领域中应用。
本发明制得的灰指甲膏，灭真菌力强，对皮肤刺激性小，无毒副作用，涂敷在患处短期内即可除掉病甲。本发明所述方案，配方精炼、操作工艺简便、制造成本低、患者使用十分方便。
具体实施方式
实施例一
取凤仙花9克，尿素25克，凡士林15克，雷锁辛10克，土槿皮酊24克，乳酸28克，水杨酸25克，将其中粗颗粒原料干燥后粉碎混合，搅拌均匀，包装即得产品灰指甲膏。
实施例二
将凤仙花10克，尿素20克，凡士林20克，雷锁辛8克，土槿皮酊20克，乳酸20克，水杨酸18克称出，再称出苦参8克，将上述干燥粉碎后的物料混合，搅拌均匀，包装即得产品灰指甲膏。
实施例三
除加入大蒜油8克外，其余操作同实施例二。
实施例四
将凤仙花10克，苦参9克，称出粉碎成100～120目的微粒，并充分混匀加入大蒜油10克再充分混匀制得Ⅰ，将尿素30克，雷锁辛9克，水杨酸20克称出后粉成细粒，充分混合制得Ⅱ，将土槿皮酊25克、乳酸23克混合制得Ⅲ，将Ⅰ加入Ⅱ搅拌均匀后再加入Ⅲ中充分混合制得Ⅳ备用，将凡士林加热至50℃然后加入Ⅳ中，充分混合即得产品灰指甲膏。

Claims (6)

1.一种灰指甲膏的制备方法，其特征在于是将将凤仙花5％～10％(重量百分数)，尿素10％～40％，凡士林5％～25％，雷锁辛5％～10％，土槿皮酊10％～30％，乳酸10％～30％，水杨酸8％～30％粉碎混合而制成灰指甲膏。
2.根据权利要求1所述的一种灰指甲膏的制备方法，其特征在于再加入苦参和/或大蒜油，加入量均为5％～8％。
3.根据权利要求1或2所述的一种灰指甲膏的制备方法，其特征在于将凤仙花，苦参粉碎混合后加入大蒜油混匀得Ⅰ，将尿素、雷锁辛、水杨酸粉碎混合得Ⅱ，将土槿皮酊、乳酸混合得Ⅲ，将Ⅰ加入Ⅱ混匀再加入Ⅲ中混合得Ⅳ，将凡士林加热至40～60℃加入Ⅳ中混匀包装即得产品。
4.根据权利要求3所述的一种灰指甲膏的制备方法，其特征在于Ⅰ的粒径较佳是100～120目。
5.根据权利要求3所述的一种灰指甲膏的制备方法，其特征在于还可加入其他添加剂。
6.根据权利要求1～6所述方法制备的灰指甲膏在医药领域的应用。
CN201810886995.4A 2018-08-06 2018-08-06 一种灰指甲膏的制备方法 Pending CN110801459A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810886995.4A CN110801459A (zh) 2018-08-06 2018-08-06 一种灰指甲膏的制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810886995.4A CN110801459A (zh) 2018-08-06 2018-08-06 一种灰指甲膏的制备方法

Publications (1)

Publication Number Publication Date
CN110801459A true CN110801459A (zh) 2020-02-18

Family

ID=69487314

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810886995.4A Pending CN110801459A (zh) 2018-08-06 2018-08-06 一种灰指甲膏的制备方法

Country Status (1)

Country Link
CN (1) CN110801459A (zh)

Similar Documents

Publication Publication Date Title
CN101780115A (zh) 中兽药微囊制剂及其制备方法
CH699835B1 (de) Wasserdispergierbarer oder wasserlöslicher Polymerfilm als Träger von dermatologischen und kosmetischen Wirkstoffen.
DE102016002122A1 (de) Detumeszenz-Odynolyse-Salbe
CN110801459A (zh) 一种灰指甲膏的制备方法
CN1150018A (zh) 中药多功能面膜及配方
CN1090961C (zh) 灰指甲膏的制备方法
DE102014213548A1 (de) Cannabispräparat
CN105148230B (zh) 一种治疗癌痛的药物及其制作方法
CN103494952A (zh) 五子衍宗丸及其制备工艺
KR20130030013A (ko) 잎새버섯 다당체를 함유하는 피부 외용제 조성물 및 이의 제조방법
CN106310042A (zh) 用中药药渣制备的药石及其制备方法
CN110801480A (zh) 一种灰指甲粉的制备方法
CN105412731A (zh) 一种治疗皮肤瘙痒症的药膏及其制备方法
CN104013936A (zh) 一种治疗猪消化不良的中药
CN108578586A (zh) 一种外用消肿止痛药及其制备方法
CN110801458A (zh) 一种灰指甲液的制备方法
CN109010571A (zh) 一种抗菌中药组合物及其制备方法
CN107441232A (zh) 一种麝香痔疮栓及其制备方法
CN102784166B (zh) 治疗家畜螨虫病的复方伊维菌素组合物及其制备方法
CN105535130A (zh) 一种增强鱼类免疫力的中药组合物
CN107050059A (zh) 脚气灵纳米乳膏
CN1613473A (zh) 禽用敌菌散的制造方法
CN114652779A (zh) 一种瞬时起效纯中药止痒油及制备方法
CN104225192A (zh) 一种治疗腿部浮肿的中药组合物及其制备方法
CN1075648A (zh) 开窍舒心片的生产方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20200218

WD01 Invention patent application deemed withdrawn after publication