CN110787259A - Traditional Chinese medicine composition for improving male sexual function and application thereof - Google Patents

Traditional Chinese medicine composition for improving male sexual function and application thereof Download PDF

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Publication number
CN110787259A
CN110787259A CN201911304779.5A CN201911304779A CN110787259A CN 110787259 A CN110787259 A CN 110787259A CN 201911304779 A CN201911304779 A CN 201911304779A CN 110787259 A CN110787259 A CN 110787259A
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parts
medicine composition
chinese medicine
traditional chinese
rhizoma
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李奇龙
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Individual
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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Abstract

The invention discloses a traditional Chinese medicine composition for improving male sexual function, which comprises the following raw materials: cynomorium songaricum, morinda officinalis, curculigo orchioides, angelica sinensis, cistanche deserticola, schisandra chinensis, red ginseng, black shun slices, cinnamon, actinolite, pepper, eucommia ulmoides, codonopsis pilosula, dogwood, epimedium herb, astragalus mongholicus, Chinese yam, prepared rehmannia root, safflower empferia mangostachya, cherokee rose, radix bupleuri, cassia twig, dragon's blood, dragon bone, wolfberry fruit, lotus seed, platycladi seed, plantain seed, rhizoma polygonati, vinegar tortoise plastron, rhizoma alismatis, rhizoma dioscoreae hypoglaucae, phellodendron amurense, rhizoma acori graminei, clove. The traditional Chinese medicine composition can remarkably improve the treatment effect on sexual dysfunction diseases such as impotence, premature ejaculation and the like, can effectively reduce facial flushing, headache and/or nasal obstruction caused by the artemisia argyi, and has simple preparation process and wide market application value.

Description

Traditional Chinese medicine composition for improving male sexual function and application thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for improving male sexual function and application thereof.
Background
Sexual dysfunction due to functional (i.e., psychological) factors is frequently accompanied by impotence and flaccidity in the room due to excessive mental stress; premature ejaculation frequently occurs due to impotence, weakness and poor self-confidence; the symptoms of the chronic diseases are acute dryness, vexation, serious heart, palpitation, timidity, mental depression and low mood, so that the impotence and premature ejaculation are aggravated and the malignant cycle is ended. In the prior art, western medicines are usually adopted to be matched with psychological behavior dispersion for treatment. However, the existing western medicines have limited treatment effects, such as wanaicao and the like, and can help ED patients to recover normal erectile function when libido impulse occurs. However, when patients use Wanyike, the reaction of flushing usually occurs on the face, headache occurs on some people, dyspepsia and nasal obstruction occur on some people, and mild visual abnormality and other side reactions occur on some people. Although some of the above-mentioned side effects, such as flushing, headache, etc., disappear after a certain period of time, they still cause discomfort to the user.
Disclosure of Invention
In view of the above, the present invention provides a Chinese medicinal composition, which is effective in improving male sexual dysfunction and reducing side effects thereof.
The purpose of the invention is realized by the following technical scheme:
the invention aims to provide a traditional Chinese medicine composition for improving male sexual function, which comprises the following raw materials in percentage by weight: 8-100 parts of cynomorium songaricum; 6-80 parts of morinda officinalis; 3-50 parts of rhizoma curculiginis; 20-70 parts of angelica; 6-80 parts of cistanche; 10-30 parts of schisandra chinensis; 10-30 parts of red ginseng; 6-30 parts of black strips; 3-20 parts of cinnamon; 10-30 parts of actinolite; 10-30 parts of pepper; 10-50 parts of eucommia; 10-30 parts of codonopsis pilosula; 10-30 parts of dogwood; 10-30 parts of epimedium; 10-30 parts of astragalus; 10-30 parts of Chinese yam; 10-30 parts of prepared rehmannia root; 10-30 parts of water lily of safflower; 10-30 parts of cherokee rose fruit; 10-30 parts of bupleurum; 10-30 parts of cassia twig; 10-30 parts of dragon blood; 10-30 parts of keel; 10-30 parts of wolfberry fruit; 10-30 parts of lotus seeds; 10-30 parts of platycladi seed; 10-30 parts of semen plantaginis; 10-30 parts of rhizoma polygonati; 10-30 parts of vinegar tortoise plastron; 10-30 parts of rhizoma alismatis; 10-30 parts of yam rhizome; 3-30 parts of phellodendron; 10-30 parts of rhizoma acori graminei; 10-30 parts of clove; 10-30 parts of raw hawthorn; 10-30 parts of Chinese starjasmine stem; 10-30 parts of deerhorn glue; 10-30 parts of pilose antler wax sheet.
In a specific embodiment of the invention, the traditional Chinese medicine composition comprises, by weight, 8-100 parts of cynomorium songaricum; 6-80 parts of morinda officinalis; 3-50 parts of rhizoma curculiginis; 20-70 parts of angelica; 6-80 parts of cistanche; 10-30 parts of schisandra chinensis; 10-30 parts of red ginseng; 6-30 parts of black strips; 3-20 parts of cinnamon; 10-30 parts of actinolite; 10-30 parts of pepper; 10-50 parts of eucommia; 10-30 parts of codonopsis pilosula; 10-30 parts of dogwood; 10-30 parts of epimedium; 10-30 parts of astragalus; 10-30 parts of Chinese yam; 10-30 parts of prepared rehmannia root; 10-30 parts of water lily of safflower; 10-30 parts of cherokee rose fruit; 10-30 parts of bupleurum; 10-30 parts of cassia twig; 10-30 parts of dragon blood; 10-30 parts of keel; 10-30 parts of wolfberry fruit; 10-30 parts of lotus seeds; 10-30 parts of platycladi seed; 10-30 parts of semen plantaginis; 10-30 parts of rhizoma polygonati; 10-30 parts of vinegar tortoise plastron; 10-30 parts of rhizoma alismatis; 10-30 parts of yam rhizome; 3-30 parts of phellodendron; 10-30 parts of rhizoma acori graminei; 10-30 parts of clove; 10-30 parts of raw hawthorn; 10-30 parts of Chinese starjasmine stem; 10-30 parts of deerhorn glue; 10-30 parts of pilose antler wax sheet.
In a specific embodiment of the invention, the traditional Chinese medicine composition comprises the following raw materials in percentage by weight: 10-80 parts of cynomorium songaricum; 8-60 parts of morinda officinalis; 3-50 parts of rhizoma curculiginis; 33-60 parts of angelica; 35-70 parts of cistanche; 13-27 parts of schisandra chinensis; 13-26 parts of red ginseng; 8-20 parts of black flake; 6-15 parts of cinnamon; 12-26 parts of actinolite; 13-25 parts of pepper; 23-43 parts of eucommia ulmoides; 16-25 parts of codonopsis pilosula; 14-23 parts of dogwood; 12-26 parts of epimedium; 12-26 parts of astragalus; 13-23 parts of Chinese yam; 15-22 parts of prepared rehmannia root; 12-25 parts of water lily of safflower; 13-24 parts of cherokee rose fruit; 13-24 parts of radix bupleuri; 14-25 parts of cassia twig; 14-25 parts of dragon's blood; 14-25 parts of keel; 14-25 parts of wolfberry fruit; 14-25 parts of lotus seeds; 14-25 parts of platycladi seed; 14-25 parts of semen plantaginis; 14-25 parts of rhizoma polygonati; 14-25 parts of vinegar tortoise plastron; 14-25 parts of rhizoma alismatis; 14-25 parts of yam rhizome; 4-20 parts of phellodendron; 15-24 parts of rhizoma acori graminei; 15-24 parts of clove; 15-24 parts of raw hawthorn; 15-24 parts of Chinese starjasmine stem; 15-24 parts of deerhorn glue; 15-24 parts of pilose antler wax sheet.
In a specific embodiment of the invention, the traditional Chinese medicine composition is prepared from, by weight, 10-80 parts of cynomorium songaricum; 8-60 parts of morinda officinalis; 3-50 parts of rhizoma curculiginis; 33-60 parts of angelica; 35-70 parts of cistanche; 13-27 parts of schisandra chinensis; 13-26 parts of red ginseng; 8-20 parts of black flake; 6-15 parts of cinnamon; 12-26 parts of actinolite; 13-25 parts of pepper; 23-43 parts of eucommia ulmoides; 16-25 parts of codonopsis pilosula; 14-23 parts of dogwood; 12-26 parts of epimedium; 12-26 parts of astragalus; 13-23 parts of Chinese yam; 15-22 parts of prepared rehmannia root; 12-25 parts of water lily of safflower; 13-24 parts of cherokee rose fruit; 13-24 parts of radix bupleuri; 14-25 parts of cassia twig; 14-25 parts of dragon's blood; 14-25 parts of keel; 14-25 parts of wolfberry fruit; 14-25 parts of lotus seeds; 14-25 parts of platycladi seed; 14-25 parts of semen plantaginis; 14-25 parts of rhizoma polygonati; 14-25 parts of vinegar tortoise plastron; 14-25 parts of rhizoma alismatis; 14-25 parts of yam rhizome; 4-20 parts of phellodendron; 15-24 parts of rhizoma acori graminei; 15-24 parts of clove; 15-24 parts of raw hawthorn; 15-24 parts of Chinese starjasmine stem; 15-24 parts of deerhorn glue; 15-24 parts of pilose antler wax sheet.
In a specific embodiment of the invention, the raw materials of the traditional Chinese medicine composition comprise, by weight, 20 parts of cynomorium songaricum; 20 parts of morinda officinalis; 20 parts of rhizoma curculiginis; 50 parts of Chinese angelica; 50 parts of cistanche; 20 parts of schisandra chinensis; 20 parts of red ginseng; 10 parts of black flake; 10 parts of cinnamon; 20 parts of actinolite; 20 parts of pepper; 30 parts of eucommia ulmoides; 20 parts of codonopsis pilosula; 20 parts of dogwood; 20 parts of epimedium; 20 parts of astragalus; 20 parts of Chinese yam; 20 parts of prepared rehmannia root; 20 parts of water lotus flower poured from safflower; 20 parts of cherokee rose fruit; 20 parts of radix bupleuri; 20 parts of cassia twig; 20 parts of dragon blood; 20 parts of keel; 20 parts of wolfberry fruit; 20 parts of lotus seeds; 20 parts of platycladi seed; 20 parts of plantain seed; 20 parts of rhizoma polygonati; 20 parts of vinegar tortoise plastron; 20 parts of rhizoma alismatis; 20 parts of yam rhizome; 6 parts of phellodendron; 20 parts of rhizoma acori graminei; 20 parts of clove; 20 parts of raw hawthorn; 20 parts of Chinese starjasmine stem; 20 parts of antler glue; 20 parts of pilose antler wax sheet.
In one specific embodiment of the invention, the raw materials of the traditional Chinese medicine composition comprise, by weight, 20 parts of cynomorium songaricum; 20 parts of morinda officinalis; 20 parts of rhizoma curculiginis; 50 parts of Chinese angelica; 50 parts of cistanche; 20 parts of schisandra chinensis; 20 parts of red ginseng; 10 parts of black flake; 10 parts of cinnamon; 20 parts of actinolite; 20 parts of pepper; 30 parts of eucommia ulmoides; 20 parts of codonopsis pilosula; 20 parts of dogwood; 20 parts of epimedium; 20 parts of astragalus; 20 parts of Chinese yam; 20 parts of prepared rehmannia root; 20 parts of water lotus flower poured from safflower; 20 parts of cherokee rose fruit; 20 parts of radix bupleuri; 20 parts of cassia twig; 20 parts of dragon blood; 20 parts of keel; 20 parts of wolfberry fruit; 20 parts of lotus seeds; 20 parts of platycladi seed; 20 parts of plantain seed; 20 parts of rhizoma polygonati; 20 parts of vinegar tortoise plastron; 20 parts of rhizoma alismatis; 20 parts of yam rhizome; 6 parts of phellodendron; 20 parts of rhizoma acori graminei; 20 parts of clove; 20 parts of raw hawthorn; 20 parts of Chinese starjasmine stem; 20 parts of antler glue; 20 parts of pilose antler wax sheet.
In a specific embodiment of the present invention, the Chinese medicinal composition further comprises pharmaceutically acceptable excipients.
The specific type of the auxiliary materials is not limited, and can be reasonably selected according to the prepared dosage form.
The auxiliary materials include but are not limited to: fillers, disintegrants, lubricants, suspending agents, binders, sweeteners, flavoring agents, preservatives, bases, and the like.
On the other hand, the invention provides a pharmaceutically acceptable preparation formulation prepared from the traditional Chinese medicine composition.
In one embodiment of the present invention, the dosage form is a tablet, capsule, granule, oral liquid, syrup, pill.
In another aspect, the present invention provides a method for preparing the above-mentioned Chinese medicinal composition, which comprises: weighing cynomorium songaricum, morinda officinalis, curculigo orchioides, angelica sinensis, cistanche deserticola, schisandra chinensis, red ginseng, black shun slices, cinnamon, actinolite, pepper, eucommia ulmoides, codonopsis pilosula, dogwood, epimedium herb, astragalus mongholicus, Chinese yam, prepared rehmannia root, mangosteen, radix bupleuri, cassia twig, dragon's blood, keel, wolfberry, lotus seeds, platycladi seeds, plantain seeds, polygonatum sibiricum, tortoise plastron, rhizoma alismatis, rhizoma dioscoreae hypoglaucae, phellodendron amurense, rhizoma acori graminei, clove, raw hawthorn, Chinese starjasmine stem, deer horn gum and pilose antler wax tablets, and adding ethanol with the alcohol content of 56% according to the mass g/.
Preferably, in the traditional Chinese medicine composition, the three traditional Chinese medicine raw materials of the cistanche, the schisandra and the dogwood are steamed before being soaked so as to change the medicine performance, expand the medicine application range, preserve the medicine effect and reduce the side effect.
Preferably, in the traditional Chinese medicine composition, the actinolite is calcined before soaking, and the calcined actinolite is crisp and easy to crush and is convenient for releasing effective components.
Preferably, in the traditional Chinese medicine composition, the eucommia ulmoides is stir-fried with salt before soaking, and the effect of stir-frying the eucommia ulmoides with salt is better than that of raw eucommia ulmoides.
Preferably, in the traditional Chinese medicine composition, the codonopsis pilosula and the astragalus membranaceus are subjected to dense roasting before soaking so as to improve the efficacy and reduce the side effects.
The traditional Chinese medicine composition provided by the invention can extract the effective components only by soaking in ethanol, and the complicated operation steps of decoction, distillation and the like in the prior art are omitted.
In one embodiment of the invention, the mass g/volume mL ratio is 1: 30.
In one embodiment of the present invention, the soaking time is 4 to 24 hours. For example, it may be 4h, 5h, 6h, 8h, 10h, 12h, 14h, 18h, 20h, 24h, etc., and preferably, the soaking time is 8 h.
In another aspect, the present invention provides the use of the above-mentioned Chinese medicinal composition for improving male sexual function.
The traditional Chinese medicine composition provided by the invention has at least one of the following beneficial effects:
the traditional Chinese medicine composition provided by the invention can obviously improve the treatment effect on sexual dysfunction diseases such as impotence and premature ejaculation, can effectively reduce facial flushing, headache and/or nasal obstruction caused by the Wanmugwort, and has simple preparation process and wide market application value.
Detailed Description
The technical solution of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Various traditional Chinese medicine raw materials in the traditional Chinese medicine composition related in the following embodiments can be purchased in the market.
Formulation 1
The formula of the traditional Chinese medicine composition is as follows: 8 parts of cynomorium songaricum; 80 parts of morinda officinalis; 3 parts of rhizoma curculiginis; 70 parts of angelica; 6 parts of cistanche; 10 parts of schisandra chinensis; 10 parts of red ginseng; 30 parts of black flake; 20 parts of cinnamon; 30 parts of actinolite; 10 parts of pepper; 50 parts of eucommia ulmoides; 10 parts of codonopsis pilosula; 10 parts of dogwood; 30 parts of epimedium; 10 parts of astragalus; 10 parts of Chinese yam; 10 parts of prepared rehmannia root; 30 parts of water lotus from safflower; 30 parts of cherokee rose fruit; 10 parts of radix bupleuri; 10 parts of cassia twig; 10 parts of dragon blood; 10 parts of keel; 30 parts of wolfberry fruit; 30 parts of lotus seeds; 30 parts of platycladi seed; 30 parts of semen plantaginis; 30 parts of rhizoma polygonati; 30 parts of vinegar tortoise plastron; 30 parts of rhizoma alismatis; 30 parts of yam rhizome; 30 parts of phellodendron; 30 parts of rhizoma acori graminei; 10 parts of clove; 10 parts of raw hawthorn; 10 parts of Chinese starjasmine stem; 10 parts of deerhorn glue; 30 parts of pilose antler wax sheet.
Formulation 2
The formula of the traditional Chinese medicine composition is as follows: 100 parts of cynomorium songaricum; 6 parts of morinda officinalis; 50 parts of rhizoma curculiginis; 20 parts of angelica; 80 parts of cistanche; 10 parts of schisandra chinensis; 30 parts of red ginseng; 6 parts of black flake; 3 parts of cinnamon; 30 parts of actinolite; 30 parts of pepper; 10 parts of eucommia ulmoides; 30 parts of codonopsis pilosula; 30 parts of dogwood; 10 parts of epimedium; 30 parts of astragalus; 30 parts of Chinese yam; 30 parts of prepared rehmannia root; 10 parts of water lotus from safflower; 10 parts of cherokee rose fruit; 10 parts of radix bupleuri; 30 parts of cassia twig; 30 parts of dragon blood; 30 parts of keel; 10 parts of wolfberry fruit; 10 parts of lotus seeds; 10 parts of platycladi seed; 10 parts of semen plantaginis; 10 parts of rhizoma polygonati; 10 parts of vinegar tortoise plastron; 10 parts of rhizoma alismatis; 10 parts of yam rhizome; 3 parts of phellodendron; 10 parts of rhizoma acori graminei; 10 parts of clove; 30 parts of raw hawthorn; 30 parts of Chinese starjasmine stem; 30 parts of deerhorn glue; 10 parts of pilose antler wax sheet.
Formulation 3
The formula of the traditional Chinese medicine composition is as follows: 80 parts of cynomorium songaricum; 8 parts of morinda officinalis; 3 parts of rhizoma curculiginis; 60 parts of angelica; 35 parts of cistanche; 27 parts of schisandra chinensis; 13 parts of red ginseng; 20 parts of black flake; 15 parts of cinnamon; 26 parts of actinolite; 13 parts of pepper; 43 parts of eucommia ulmoides; 16 parts of codonopsis pilosula; 23 parts of dogwood; 12 parts of epimedium; 12 parts of astragalus; 13 parts of Chinese yam; 15 parts of prepared rehmannia root; 25 parts of water lotus flower poured from safflower; 13 parts of cherokee rose fruit; 13 parts of radix bupleuri; 14 parts of cassia twig; 14 parts of dragon blood; 14 parts of keel; 25 parts of wolfberry fruit; 14 parts of lotus seeds; 25 parts of platycladi seed; 14 parts of semen plantaginis; 25 parts of rhizoma polygonati; 25 parts of vinegar tortoise plastron; 14 parts of rhizoma alismatis; 25 parts of yam rhizome; 20 parts of phellodendron; 24 parts of rhizoma acori graminei; 24 parts of clove; 24 parts of raw hawthorn; 15 parts of Chinese starjasmine stem; 15 parts of deerhorn glue; 15 parts of pilose antler wax sheet.
Formulation 4
The formula of the traditional Chinese medicine composition is as follows: 10 parts of cynomorium songaricum; 60 parts of morinda officinalis; 50 parts of rhizoma curculiginis; 33 parts of angelica; 70 parts of cistanche; 13 parts of schisandra chinensis; 26 parts of red ginseng; 8 parts of black flake; 6 parts of cinnamon; 12 parts of actinolite; 13 parts of pepper; 23 parts of eucommia ulmoides; 25 parts of codonopsis pilosula; 14 parts of dogwood; 26 parts of epimedium; 26 parts of astragalus; 23 parts of Chinese yam; 22 parts of prepared rehmannia root; 12 parts of water lotus from safflower; 24 parts of cherokee rose fruit; 24 parts of radix bupleuri; 25 parts of cassia twig; 25 parts of dragon's blood; 25 parts of keel; 14 parts of wolfberry fruit; 25 parts of lotus seeds; 14 parts of platycladi seed; 25 parts of semen plantaginis; 14 parts of rhizoma polygonati; 14 parts of vinegar tortoise plastron; 14 parts of rhizoma alismatis; 14 parts of yam rhizome; 4 parts of phellodendron; 15 parts of rhizoma acori graminei; 15 parts of clove; 15 parts of raw hawthorn; 24 parts of Chinese starjasmine stem; 24 parts of deerhorn glue; 15 parts of pilose antler wax sheet.
Formulation 5
The formula of the traditional Chinese medicine composition is as follows: 20 parts of cynomorium songaricum; 20 parts of morinda officinalis; 20 parts of rhizoma curculiginis; 50 parts of Chinese angelica; 50 parts of cistanche; 20 parts of schisandra chinensis; 20 parts of red ginseng; 10 parts of black flake; 10 parts of cinnamon; 20 parts of actinolite; 20 parts of pepper; 30 parts of eucommia ulmoides; 20 parts of codonopsis pilosula; 20 parts of dogwood; 20 parts of epimedium; 20 parts of astragalus; 20 parts of Chinese yam; 20 parts of prepared rehmannia root; 20 parts of water lotus flower poured from safflower; 20 parts of cherokee rose fruit; 20 parts of radix bupleuri; 20 parts of cassia twig; 20 parts of dragon blood; 20 parts of keel; 20 parts of wolfberry fruit; 20 parts of lotus seeds; 20 parts of platycladi seed; 20 parts of plantain seed; 20 parts of rhizoma polygonati; 20 parts of vinegar tortoise plastron; 20 parts of rhizoma alismatis; 20 parts of yam rhizome; 6 parts of phellodendron; 20 parts of rhizoma acori graminei; 20 parts of clove; 20 parts of raw hawthorn; 20 parts of Chinese starjasmine stem; 20 parts of antler glue; 20 parts of pilose antler wax sheet.
Formulation 6
The formula of the traditional Chinese medicine composition is as follows: 73 parts of cynomorium songaricum; 57 parts of morinda officinalis; 32 parts of rhizoma curculiginis; 43 parts of Chinese angelica; 58 parts of cistanche; 16 parts of schisandra chinensis; 15 parts of red ginseng; 10 parts of black flake; 22 parts of cinnamon; 12 parts of actinolite; 17 parts of pepper; 28 parts of eucommia ulmoides; 20 parts of codonopsis pilosula; 25 parts of dogwood; 19 parts of epimedium; 17 parts of astragalus; 16 parts of Chinese yam; prepared rehmannia root 28 parts; pouring 24 parts of water lotus from the safflower; 16 parts of cherokee rose fruit; 22 parts of radix bupleuri; 28 parts of cassia twig; 25 parts of dragon's blood; 14 parts of keel; 21 parts of wolfberry fruit; 19 parts of lotus seeds; 22 parts of platycladi seed; 15 parts of semen plantaginis; 29 parts of rhizoma polygonati; 23 parts of vinegar tortoise plastron; 14 parts of rhizoma alismatis; 17 parts of yam rhizome; 5 parts of phellodendron; 21 parts of rhizoma acori graminei; 22 parts of clove; 22 parts of raw hawthorn; 12 parts of Chinese starjasmine stem; 10 parts of deerhorn glue; 13 parts of pilose antler wax sheet.
Formulation 7
The formula of the traditional Chinese medicine composition is as follows: 50 parts of cynomorium songaricum; 42 parts of morinda officinalis; 25 parts of rhizoma curculiginis; 38 parts of Chinese angelica; 57 parts of cistanche; 17 parts of schisandra chinensis; 26 parts of red ginseng; 20 parts of black flake; 9 parts of cinnamon; 16 parts of actinolite; 15 parts of pepper; 31 parts of eucommia ulmoides; 21 parts of codonopsis pilosula; 19 parts of dogwood; 17 parts of epimedium; 15 parts of astragalus; 18 parts of Chinese yam; 22 parts of prepared rehmannia root; 12 parts of water lotus from safflower; 14 parts of cherokee rose fruit; 19 parts of radix bupleuri; 15 parts of cassia twig; 20 parts of dragon blood; 21 parts of keel; 20 parts of wolfberry fruit; 24 parts of lotus seeds; 14 parts of platycladi seed; 25 parts of semen plantaginis; 19 parts of rhizoma polygonati; 23 parts of vinegar tortoise plastron; 22 parts of rhizoma alismatis; 17 parts of yam rhizome; 9 parts of phellodendron; 17 parts of rhizoma acori graminei; 16 parts of clove; 18 parts of raw hawthorn; 24 parts of Chinese starjasmine stem; 20 parts of antler glue; 20 parts of pilose antler wax sheet.
Formulation 8
The formula of the traditional Chinese medicine composition is as follows: 69 parts of cynomorium songaricum; 26 parts of morinda officinalis; 17 parts of rhizoma curculiginis; 38 parts of Chinese angelica; 55 parts of cistanche; 25 parts of schisandra chinensis; 20 parts of red ginseng; 14 parts of black flake; 12 parts of cinnamon; 15 parts of actinolite; 25 parts of pepper; 33 parts of eucommia ulmoides; 25 parts of codonopsis pilosula; 20 parts of dogwood; 25 parts of epimedium; 20 parts of astragalus; 15 parts of Chinese yam; 18 parts of prepared rehmannia root; 15 parts of water lotus are poured into the safflower; 14 parts of cherokee rose fruit; 19 parts of radix bupleuri; 22 parts of cassia twig; 23 parts of dragon blood; 19 parts of keel; 15 parts of wolfberry fruit; 20 parts of lotus seeds; 17 parts of platycladi seed; 17 parts of semen plantaginis; 18 parts of rhizoma polygonati; 22 parts of vinegar tortoise plastron; 24 parts of rhizoma alismatis; 15 parts of yam rhizome; 6 parts of phellodendron; 14 parts of rhizoma acori graminei; 25 parts of clove; 20 parts of raw hawthorn; 19 parts of Chinese starjasmine stem; 19 parts of deerhorn glue; 17 parts of pilose antler wax sheet.
The preparation of the traditional Chinese medicine composition comprises the following steps: weighing cynomorium songaricum, morinda officinalis, curculigo orchioides, angelica, cistanche deserticola, schisandra chinensis, red ginseng, black shun tablets, cinnamon, actinolite, pepper, eucommia ulmoides, codonopsis pilosula, dogwood, epimedium, astragalus mongholicus, Chinese yam, prepared rehmannia root, safflower empferia mangostachya, cherokee rose, radix bupleuri, cassia twig, dragon's blood, keel, wolfberry, lotus seed, platycladi seed, plantain seed, rhizoma polygonati, vinegar tortoise plastron, rhizoma alismatis, rhizoma dioscoreae hypoglaucae, phellodendron amurense, rhizoma acori graminei, clove, raw hawthorn, Chinese starjasmine stem, deer horn gum and pilose antler wax tablets, and adding 56% ethanol according to a mass g/volume.
Experimental example 1
Animal experiments: the curative effect of the traditional Chinese medicine composition for treating impotence is tested.
40 male rats were randomly divided into 10 groups, and duration of the rats' capture latency, ejaculation latency was observed and recorded.
The test method comprises the following steps:
experimental groups: concentrating the above prepared Chinese medicinal composition into extract, collecting 100mg, adding double distilled water to obtain 0.1g/mL, and continuously intragastrically infusing according to 0.5mL/100g body weight for 28 days, once a day.
Wanaike group: when the traditional Chinese medicine composition is used for perfusing rats, the group simultaneously feeds the rats with the same dose of the Wan ai Ke. Vanamcor, 100 mg/tablet, produced by Peucel pharmaceuticals, Inc., USA.
After each administration, the capture latency and ejaculation latency of the rats were recorded and observed, and the results are shown in table 1.
TABLE 1 Effect of Chinese medicinal compositions on Capture latency and ejaculation latency in rats
Group of Number of Capture latency (second) Latency period of ejaculation (second)
Blank control 4 302.4±36.2 856.2±92.8
Formulation 1 4 145.6±17.9 280.4±30.2
Formulation of2 4 139.5±16.2 256.3±27.4
Formulation 3 4 140.9±16.4 258.1±27.9
Formulation 4 4 132.1±16.9 252.4±27.1
Formulation 5 4 125.2±15.3 249.5±26.7
Formulation 6 4 136.4±17.1 256.3±27.3
Formulation 7 4 135.0±17.0 252.9±27.2
Formulation 8 4 142.3±17.3 267.2±28.7
Wan ai Ke group 4 175.6±23.2 340.2±41.5
As can be seen from table 1, compared with the control and the warfarin, the traditional Chinese medicine composition of the present application has the effects of shortening the erection incubation period of the experimental rat, increasing the index of the perigonadal visceral organs, shortening the incubation period of the capture and ejaculation, and is suggested to have the pharmacodynamic effect of increasing the sexual ability of the experimental rat.
Experimental example two
Clinical trial
60 outpatient 30-50 years old male sexual dysfunction patients were selected and randomly assigned to blank, waniger and treatment groups, each of 20.
Blank group: without any drug treatment.
Wanaike group: one tablet, 25 mg/tablet, is taken periodically daily for treatment.
Treatment groups: the wine prepared from the traditional Chinese medicine composition provided by the formula 5 is taken regularly every day for treatment, wherein the wine is 250 mL.
Follow-up observation for 2 months, and record the condition of flushing, headache and nasal obstruction after each treatment. The results of the experiment are shown in table 2.
TABLE 2 Experimental results of side effects of the Chinese medicinal composition of the above formulas
Group of Flushing of the face Headache pain Nasal obstruction
Formulation 5 2 0 0
Blank group 0 0 0
Wan ai Ke 18 15 11
As can be seen from table 2, the patients in the blank group who were not treated with any drug did not develop symptoms of flushing, headache, nasal congestion. Compared with the wangnac, the traditional Chinese medicine composition provided by the formula 5 can obviously reduce the side effects of flushing, headache, nasal obstruction and the like on the face of a patient.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and the like that are within the spirit and principle of the present invention are included in the present invention.

Claims (10)

1. The traditional Chinese medicine composition for improving male sexual function is characterized by comprising the following raw materials in percentage by weight: 8-100 parts of cynomorium songaricum; 6-80 parts of morinda officinalis; 3-50 parts of rhizoma curculiginis; 20-70 parts of angelica; 6-80 parts of cistanche; 10-30 parts of schisandra chinensis; 10-30 parts of red ginseng; 6-30 parts of black strips; 3-20 parts of cinnamon; 10-30 parts of actinolite; 10-30 parts of pepper; 10-50 parts of eucommia; 10-30 parts of codonopsis pilosula; 10-30 parts of dogwood; 10-30 parts of epimedium; 10-30 parts of astragalus; 10-30 parts of Chinese yam; 10-30 parts of prepared rehmannia root; 10-30 parts of water lily of safflower; 10-30 parts of cherokee rose fruit; 10-30 parts of bupleurum; 10-30 parts of cassia twig; 10-30 parts of dragon blood; 10-30 parts of keel; 10-30 parts of wolfberry fruit; 10-30 parts of lotus seeds; 10-30 parts of platycladi seed; 10-30 parts of semen plantaginis; 10-30 parts of rhizoma polygonati; 10-30 parts of vinegar tortoise plastron; 10-30 parts of rhizoma alismatis; 10-30 parts of yam rhizome; 3-30 parts of phellodendron; 10-30 parts of rhizoma acori graminei; 10-30 parts of clove; 10-30 parts of raw hawthorn; 10-30 parts of Chinese starjasmine stem; 10-30 parts of deerhorn glue; 10-30 parts of pilose antler wax sheet.
2. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition comprises the following raw materials in percentage by weight: 10-80 parts of cynomorium songaricum; 8-60 parts of morinda officinalis; 3-50 parts of rhizoma curculiginis; 33-60 parts of angelica; 35-70 parts of cistanche; 13-27 parts of schisandra chinensis; 13-26 parts of red ginseng; 8-20 parts of black flake; 6-15 parts of cinnamon; 12-26 parts of actinolite; 13-25 parts of pepper; 23-43 parts of eucommia ulmoides; 16-25 parts of codonopsis pilosula; 14-23 parts of dogwood; 12-26 parts of epimedium; 12-26 parts of astragalus; 13-23 parts of Chinese yam; 15-22 parts of prepared rehmannia root; 12-25 parts of water lily of safflower; 13-24 parts of cherokee rose fruit; 13-24 parts of radix bupleuri; 14-25 parts of cassia twig; 14-25 parts of dragon's blood; 14-25 parts of keel; 14-25 parts of wolfberry fruit; 14-25 parts of lotus seeds; 14-25 parts of platycladi seed; 14-25 parts of semen plantaginis; 14-25 parts of rhizoma polygonati; 14-25 parts of vinegar tortoise plastron; 14-25 parts of rhizoma alismatis; 14-25 parts of yam rhizome; 4-20 parts of phellodendron; 15-24 parts of rhizoma acori graminei; 15-24 parts of clove; 15-24 parts of raw hawthorn; 15-24 parts of Chinese starjasmine stem; 15-24 parts of deerhorn glue; 15-24 parts of pilose antler wax sheet.
3. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition comprises the following raw materials in percentage by weight: 20 parts of cynomorium songaricum; 20 parts of morinda officinalis; 20 parts of rhizoma curculiginis; 50 parts of Chinese angelica; 50 parts of cistanche; 20 parts of schisandra chinensis; 20 parts of red ginseng; 10 parts of black flake; 10 parts of cinnamon; 20 parts of actinolite; 20 parts of pepper; 30 parts of eucommia ulmoides; 20 parts of codonopsis pilosula; 20 parts of dogwood; 20 parts of epimedium; 20 parts of astragalus; 20 parts of Chinese yam; 20 parts of prepared rehmannia root; 20 parts of water lotus flower poured from safflower; 20 parts of cherokee rose fruit; 20 parts of radix bupleuri; 20 parts of cassia twig; 20 parts of dragon blood; 20 parts of keel; 20 parts of wolfberry fruit; 20 parts of lotus seeds; 20 parts of platycladi seed; 20 parts of plantain seed; 20 parts of rhizoma polygonati; 20 parts of vinegar tortoise plastron; 20 parts of rhizoma alismatis; 20 parts of yam rhizome; 6 parts of phellodendron; 20 parts of rhizoma acori graminei; 20 parts of clove; 20 parts of raw hawthorn; 20 parts of Chinese starjasmine stem; 20 parts of antler glue; 20 parts of pilose antler wax sheet.
4. The traditional Chinese medicine composition of any one of claims 1-3, further comprising a pharmaceutically acceptable adjuvant.
5. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition is prepared into a pharmaceutically acceptable dosage form.
6. The traditional Chinese medicine composition of claim 5, wherein the dosage form is tablets, capsules, granules, oral liquid, syrup, pills.
7. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition is prepared by the following method: weighing cynomorium songaricum, morinda officinalis, curculigo orchioides, angelica sinensis, cistanche deserticola, schisandra chinensis, red ginseng, black shun slices, cinnamon, actinolite, pepper, eucommia ulmoides, codonopsis pilosula, dogwood, epimedium herb, astragalus mongholicus, Chinese yam, prepared rehmannia root, mangosteen, radix bupleuri, cassia twig, dragon's blood, keel, wolfberry, lotus seeds, platycladi seeds, plantain seeds, polygonatum sibiricum, tortoise plastron, rhizoma alismatis, rhizoma dioscoreae hypoglaucae, phellodendron amurense, rhizoma acori graminei, clove, raw hawthorn, Chinese starjasmine stem, deer horn gum and pilose antler wax tablets, and adding ethanol with the alcohol content of 56% according to the mass g/.
8. The traditional Chinese medicine composition of claim 7, wherein the mass g/volume mL ratio is 1: 30.
9. The traditional Chinese medicine composition of claim 7, wherein the soaking time is 4-24 h.
10. Use of the Chinese medicinal composition of any one of claims 1-9 for improving male sexual function.
CN201911304779.5A 2019-12-17 2019-12-17 Traditional Chinese medicine composition for improving male sexual function and application thereof Pending CN110787259A (en)

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CN104771563A (en) * 2015-04-29 2015-07-15 岳阳新华达制药有限公司 Kidney tonifying Chinese herbal medicine compound preparation and preparation method thereof
CN107519375A (en) * 2017-10-25 2017-12-29 沈阳易和生物科技有限公司 A kind of kidney-tonifying sperm-generating wine and preparation method thereof

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CN103211958A (en) * 2013-05-13 2013-07-24 陕西立众制药有限公司 Traditional Chinese medicine composition for invigorating kidney, strengthening yang, replenishing essence, and reinforcing vitality, and preparation method thereof
CN104771563A (en) * 2015-04-29 2015-07-15 岳阳新华达制药有限公司 Kidney tonifying Chinese herbal medicine compound preparation and preparation method thereof
CN107519375A (en) * 2017-10-25 2017-12-29 沈阳易和生物科技有限公司 A kind of kidney-tonifying sperm-generating wine and preparation method thereof

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