CN110772580A - Sleep-regulating composition, compound essential oil and application thereof - Google Patents
Sleep-regulating composition, compound essential oil and application thereof Download PDFInfo
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Abstract
The invention provides a sleep-regulating composition, compound essential oil and application thereof. The compound essential oil comprises the following raw materials in parts by weight: 0.5-3 parts of tangerine peel essential oil, 0.5-3 parts of green tangerine peel essential oil, 0.6-3 parts of agilawood essential oil, 0.1-0.9 part of radix bupleuri essential oil, 0.1-0.9 part of white paeony root essential oil and 0.1-0.9 part of gardenia essential oil. The use method of the compound essential oil comprises any one of aromatherapy sniffing, spraying, smearing and massaging. The compound essential oil provided by the invention is safe, low in toxicity, less in side effect and free of drug resistance, and under the guidance of the theory of traditional Chinese medicine, the essential oil is reasonably mixed, so that the effect is enhanced, and the curative effect is enlarged.
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to the technical field of natural product application, and in particular relates to a composition for regulating sleep, compound essential oil and application thereof.
[ background of the invention ]
Sleep is one of important contents in daily life of people, and the sleep time is about more than 3 times in a life of a person. A study by the world health organization has shown that about 27% of people worldwide suffer from sleep disorders, about 35.2% of people in western countries have varying degrees of insomnia, and the incidence of insomnia in chinese adults is 38.2%. Insomnia affects the life and work of patients to different degrees, and causes the decline of the attention, judgment, memory and daily working ability of the patients, and causes depression, anxiety or fear of the psychology of the patients. In addition, insomnia is also an independent risk factor for coronary heart disease, diabetes, and the like.
There are many ways to improve insomnia, such as taking hypnotics. However, the current drugs for clinically treating insomnia mainly comprise melatonin receptor agonists, benzodiazepine receptor agonists, antidepressant drugs with hypnotic effect and the like, but the drugs usually have strong side effects such as dizziness, reaction retardation or somnolence after being taken for a long time.
The traditional Chinese medicine aromatherapy has four characteristics of accuracy, uniqueness, quick effect and naturalness, and has three main effects of treating diseases, synergistic effect of treating diseases and rehabilitation and conditioning core. The theory of traditional Chinese medicine indicates that aromatic drugs permeate into human body through skin, channels and collaterals and other ways, and play a role in opening and relaxing striae, promoting blood circulation to remove blood stasis, and smoothing and balancing yin and yang. The fragrant medicines in the traditional Chinese medicine aromatherapy mainly utilize the volatile substances to achieve the purpose of preventing and treating diseases. At present, rose, lavender, bergamot and chamomile are taken as main aromatic essential oils for treating insomnia in western countries, and although some aromatic traditional Chinese medicines or essential oils are used for treating insomnia by an inhalation method at present, reasonable compatibility under the guidance of the traditional Chinese medicine theory is lacked, so the invention provides the composition for regulating sleep, the compound essential oil and the application thereof, wherein the reasonable compatibility is under the guidance of the traditional Chinese medicine theory.
[ summary of the invention ]
At present, the drugs for clinically treating insomnia in the prior art usually have strong side effects such as dizziness, reaction retardation, somnolence and the like after being taken for a long time, and meanwhile, the aromatic essential oil for treating insomnia in western countries mainly comprises rose, lavender, bergamot and chamomile and lacks of reasonable compatibility under the guidance of the traditional Chinese medicine theory, so that the invention provides the composition for regulating sleep, the compound essential oil and the application thereof.
The composition for regulating sleep comprises the following raw materials in parts by weight: 0.5-3 parts of dried orange peel, 0.5-3 parts of green tangerine peel, 0.6-3 parts of agilawood, 0.1-0.9 part of radix bupleuri, 0.1-0.9 part of white paeony root and 0.1-0.9 part of gardenia.
Preferably, the composition comprises the following raw materials in parts by weight: 0.9 to 3 portions of dried orange peel, 0.9 to 2.1 portions of green tangerine orange peel, 0.9 to 2.1 portions of agilawood, 0.1 to 0.7 portion of bupleurum, 0.1 to 0.7 portion of white paeony root and 0.1 to 0.6 portion of gardenia.
Preferably, the composition comprises the following raw materials in parts by weight: 0.9 to 1.5 portions of dried orange peel, 0.9 to 1.5 portions of green peel, 0.9 to 1.5 portions of agilawood, 0.1 to 0.5 portion of radix bupleuri, 0.1 to 0.5 portion of white paeony root and 0.1 to 0.4 portion of gardenia.
The invention also provides the compound essential oil for adjusting sleep, and the compound essential oil comprises the composition for adjusting sleep.
Preferably, the use method of the compound essential oil comprises any one of aromatherapy sniffing, spraying, smearing and massaging.
Preferably, the extraction method of the pericarpium citri reticulatae essential oil, the pericarpium citri reticulatae viride essential oil, the agilawood essential oil, the radix bupleuri essential oil, the radix paeoniae alba essential oil and the fructus gardeniae essential oil is one of steam distillation, squeezing, supercritical extraction, chemical solvent extraction, oil separation (fat absorption) or soaking.
The invention also provides application of the sleep-regulating composition in the field of traditional Chinese medicine, wherein the composition comprises any one of a sachet, a medicine pillow, a medicine incense, a navel patch and an incense bag.
Compared with the prior art, the agilawood, the dried orange peel, the green tangerine peel, the radix bupleuri, the white paeony root and the gardenia in the compound essential oil provided by the invention are natural plants, and are safe, low in toxicity, less in side effect and free of drug resistance; the compound essential oil has flexible and various use modes; the essential oil has a small molecular structure, is easy to permeate skin and can accelerate absorption; compared with single-component essential oil, the compound essential oil provided by the invention is reasonably compatible by utilizing different effects of the essential oil in the formula on the basis of the compatibility theory of the traditional Chinese medicine, enhances the effect, enlarges the curative effect, and has quick response and good curative effect.
[ detailed description ] embodiments
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the tables in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a composition for regulating sleep, which comprises the following raw materials in parts by weight: 0.5 to 3 portions of dried orange peel, 0.5 to 3 portions of green tangerine orange peel, 0.6 to 3 portions of agilawood, 0.1 to 0.9 portion of bupleurum, 0.1 to 0.9 portion of white peony root and 0.1 to 0.9 portion of gardenia.
The invention also provides application of the sleep-regulating composition in the field of traditional Chinese medicine, wherein the composition comprises any one of a sachet, a medicine pillow, a medicine incense, a navel patch and an incense bag.
Meanwhile, the invention also provides the compound essential oil for adjusting sleep, which comprises the following raw materials in parts by weight:
0.5-3 parts of tangerine peel essential oil, 0.5-3 parts of green tangerine peel essential oil, 0.6-3 parts of agilawood essential oil, 0.1-0.9 part of radix bupleuri essential oil, 0.1-0.9 part of white paeony root essential oil and 0.1-0.9 part of gardenia essential oil.
Further, the compound essential oil comprises the following raw materials in parts by weight: 0.9-3 parts of tangerine peel essential oil, 0.9-2.1 parts of green tangerine peel essential oil, 0.9-2.1 parts of agilawood essential oil, 0.1-0.7 part of radix bupleuri essential oil, 0.1-0.7 part of white paeony root essential oil and 0.1-0.6 part of gardenia essential oil.
Furthermore, the compound essential oil comprises the following raw materials in parts by weight: 0.9-1.5 parts of tangerine peel essential oil, 0.9-1.5 parts of green tangerine peel essential oil, 0.9-1.5 parts of agilawood essential oil, 0.1-0.5 part of radix bupleuri essential oil, 0.1-0.5 part of white paeony root essential oil and 0.1-0.4 part of gardenia essential oil.
The use method of the compound essential oil comprises one of aromatherapy sniffing, spraying, smearing and massaging.
The essential oil of the compound essential oil can be obtained by direct purchase, or can be obtained by extracting the original plant as the raw material by using a conventional essential oil extraction method, wherein the conventional essential oil extraction method includes, but is not limited to, one of a steam distillation method, a squeezing method, a supercritical extraction method, a chemical solvent extraction method, a fat separation method (fat absorption method), or a soaking method. In a preferred embodiment, the tangerine peel essential oil, the green tangerine peel essential oil, the agilawood essential oil, the radix bupleuri essential oil, the radix paeoniae alba essential oil and the gardenia essential oil are respectively prepared by taking tangerine peel, green tangerine peel, agilawood, radix bupleuri, radix paeoniae alba and gardenia as raw materials and extracting the volatile oils by adopting a steam distillation method. The steam distillation method is a conventional method for extracting essential oil, and is not described in detail herein.
The invention is further illustrated by the following specific examples, which, however, are to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever.
Example 1
The compound essential oil comprises the following components in parts by weight:
2.5 parts of tangerine peel essential oil, 2.0 parts of green tangerine peel essential oil, 2.6 parts of agilawood essential oil, 0.1 part of bupleurum essential oil, 0.1 part of white paeony root essential oil and 0.1 part of gardenia essential oil.
Example 2
The compound essential oil comprises the following components in parts by weight:
1.5 parts of tangerine peel essential oil, 1.5 parts of green tangerine peel essential oil, 1.2 parts of agilawood essential oil, 0.2 parts of radix bupleuri essential oil, 0.2 parts of white paeony root essential oil and 0.1 part of gardenia essential oil.
Example 3
The compound essential oil comprises the following components in parts by weight:
0.5 part of tangerine peel essential oil, 0.5 part of green tangerine peel essential oil, 0.6 part of agilawood essential oil, 0.2 part of bupleurum essential oil, 0.2 part of white paeony root essential oil and 0.1 part of gardenia essential oil.
Comparative example 1
The compound essential oil comprises the following components in parts by weight: 2.5 parts of tangerine peel essential oil and 2.6 parts of agilawood essential oil.
Comparative example 2
The compound essential oil comprises the following components in parts by weight: 1.5 parts of tangerine peel essential oil and 1.5 parts of green tangerine peel essential oil.
Comparative example 3
The compound essential oil comprises the following components in parts by weight: 0.5 part of tangerine peel essential oil and 0.6 part of agilawood essential oil.
Animal behavioral testing experiment:
experimental animals: 72 SPF-class S-day rats weighing 180-220 g are normally bred in a normal-temperature quiet animal environment.
Grouping experiments: after 7 days of adaptive feeding, the rats were randomly divided into 9 groups of 8 rats each with half of male and female according to body weight, including a blank group, a model group, a positive group, 3 administration groups and 3 control groups.
Establishing a model: the blank group had no any external stimulation, and the other groups had their forelimbs restrained by medical adhesive tape to restrict their movement, and kept holding the rat tail every day, which was located at the position away from the proximal end 1/3 for 45 minutes every day, and kept in a fighting state for 20 consecutive days, with no bleeding on the skin.
Administration: the rats in the model group and each administration group were injected with 450mg/kg of p-chlorophenylalanine (PCPA) dissolved in physiological saline for 2 consecutive days from the model establishment day 16. From the 7 th day of tail clamping stimulation, the positive group is perfused with 1mg/kg diazepam solution dissolved by normal saline; perfusing normal saline with the same volume as the diazepam solution into the stomach in the blank group and the model group; aromatherapy was given once daily for 14 consecutive days to 3 dosing groups and 3 control groups. Specifically, the compound essential oils of examples 1 to 3 were administered to three groups of administration groups for aromatherapy inhalation. The aromatherapy sniffing method is used by an aromatherapy sniffing device, and the aromatherapy sniffing device main body consists of a large transparent organic glass box with the specification of 80 x 65cm and a cover and four small transparent organic glass boxes with the specification of 30 x 30 cm. The small boxes are evenly placed at the bottom of the large box, and the aromatherapy atomizer used for containing essential oil is placed in the center of the large box. Rats were placed in the aromatherapy sniffing device, and the compound essential oil provided in examples 1-3 was added to the spray pot of the aromatherapy atomizer, respectively, with sniffing time of 1h per group. And testing after the sniffing is finished.
Index detection: the rat open field test was performed within 1 hour after the end of the dosing. The light of the laboratory is kept constant and dim, the lowest brightness at a distance of 1.5cm for distinguishing the fine activities of the rats is taken as the standard, the room temperature is 20 +/-1 ℃, the humidity is 60-70%, and the laboratory is kept quiet. The bottom surface of the open field is black, and a camera is arranged right above the central area of the open field. The rat is placed in a laboratory to adapt for 10 minutes, the rat is rapidly placed in the center of an open field after the beginning of the experiment, the head of the rat is fixed towards one side, a video analysis system is started immediately after the rat is released, and the video is automatically collected. The adaptability of each rat in the open field box is measured for 3 minutes, the measurement time is 5 minutes, fecal particles and urine left by the rat are removed after the measurement is finished, the environment in the box is cleaned by low-concentration alcohol, and the next 1 rat is carried out after the alcohol is volatilized and smells less. Taking less than 2cm/s as rest, taking more than 20cm/s as fast movement, and measuring by adopting a single-target tracking mode, and recording the maximum speed, the average speed, the movement speed, the rest time, the low-speed movement time and the high-speed movement time of each rat.
After the treatment of each group of rats is finished, the rat is killed by cutting off the head, the hypothalamus and hippocampus tissues of the rat are quickly taken out, the rat is weighed after being washed by phosphate buffer solution, the phosphate buffer solution with 9 times of volume is added, and an electric homogenizer is used for homogenate. Centrifuging at 4 deg.C for 10 min at 3500 r/min, collecting supernatant, and storing at-20 deg.C. The enzyme-linked immunosorbent assay is adopted to strictly operate according to the instruction of a corresponding kit, and the content of 5-hydroxytryptamine (also known as serotonin, 5-HT for short), glutamic acid (Glutamic acid for short), gamma-aminobutyric acid (GABA for short) and the ratio of glutamic acid to gamma-aminobutyric acid (Glu/GABA) in hypothalamus and hippocampus tissues of each group of rats is determined.
Wherein, 5-HT, Glu and GABA are all neurotransmitters. Specifically, 5-HT has functions of regulating sleep and maintaining mental stability. GABA is an inhibitory transmitter, maintains the balance of excitation inhibition in brain, and hypofunction can cause insufficient inhibition function in brain, and causes headache, anxiety, nervousness, irritability and other conditions. GLu is involved in higher functions of the brain, glutamate plays an important role in learning, memory, neuronal plasticity and brain development, and GLu together with GABA regulates the function of other neurotransmitters. That is, the levels of 5-HT, Glu and GABA in the hypothalamus and hippocampus tissues can reflect the mental and neurological status of the organism.
Table 1 shows the statistical results of the measures of the indexes related to the autonomic activity of the rats in each group (
n＝8)
| Grouping | Maximum speed | Average velocity | Distance of movement | Rest time |
| Blank group | 13.05±1.92 | 1.70±0.69 | 510.81±205.92 | 224.63±33.40 |
| Model set | 9.57±2.25* | 0.80±0.34** | 240.43±101.44** | 265.58±17.44** |
| Positive group | 11.14±1.58 | 0.60±0.24** | 180.74±73.55** | 277.60±12.16** |
| Example 1 | 5.05±3.97** △△ | 0.36±0.36** | 107.70±108.17** | 287.03±18.65** |
| Example 2 | 4.45±3.78** △△ | 0.27±0.21** △ | 80.19±62.50** △ | 292.60±10.17** △ |
| Example 3 | 3.38±2.53** △△ | 0.19±0.09** △△ | 57.93±25.12** △△ | 298.57±1.93** △△ |
| Comparative example 1 | 8.56±5.55* | 0.86±0.62* | 256.23±186.96* | 263.13±35.68 |
| Comparative example 2 | 10.93±4.28 | 1.12±0.68 | 334.79±204.75* | 252.70±35.02 |
| Comparative example 3 | 7.68±5.43* | 0.73±0.56** | 214.54±164.95** | 273.90±24.91* |
Note that the results are expressed as mean. + -. standard error, statistically processed by t-test, compared to the blank group, P < 0.05, P < 0.01, compared to the model group, △ P < 0.05, △△ P < 0.01.
As can be seen from Table 1, compared with the blank group, the model group and the positive group, the examples 1 to 3 in the administration group significantly reduce the moving distance, the maximum speed and the average speed of the rat in the open field experiment and simultaneously increase the rest time of the rat in the open field experiment, and the examples and the corresponding comparative examples show that the effect of the examples is better than that of the comparative examples, namely the compound essential oil provided by the invention can reduce the moving distance, the maximum speed and the average speed of the rat in the open field experiment and increase the rest time of the rat in the open field experiment, and has more obvious effect compared with the control group only containing the agilawood essential oil and the tangerine peel essential oil.
Table 2 shows the statistics of the 5-HT, Glu, GABA and Glu/GABA content in the hypothalamus and hippocampus tissues of each group of rats: (
n＝8)。
| Group of | 5-HT(pg/ml) | Glu(umol/L) | GABA(umol/L) | Glu/GABA |
| Blank group | 101.48±9.58 | 11.33±1.46 | 14.13±0.88 | 0.80±0.11 |
| Model set | 205.93±12.52 ** | 23.18±0.82 ** | 6.36±0.71 ** | 3.69±0.42 ** |
| Positive group | 128.58±9.76 **△△ | 14.38±2.28 **△△ | 11.28±1.26 **△△ | 1.29±0.25 *△△ |
| Example 1 | 150.18±26.65 **△△ | 17.89±1.68 **△△ | 9.90±1.30 **△△ | 1.83±0.26 **△△ |
| Example 2 | 174.84±15.04 **△△ | 18.27±2.58 **△△ | 8.50±0.96 **△△ | 2.18±0.42 **△△ |
| Example 3 | 198.12±15.18 ** | 20.14±2.42 **△△ | 7.30±0.73 ** | 2.80±0.52 **△△ |
| Comparative example 1 | 178.23±13.27 **△ | 18.94±3.05 **△△ | 8.79±1.08 **△ | 2.60±0.39 **△△ |
| Comparative example 2 | 181.90±16.36 ** | 19.18±2.84 **△ | 8.06±0.69 ** | 2.78±0.47 **△ |
| Comparative example 3 | 199.34±16.79 ** | 21.68±2.67 ** | 7.01±0.47 ** | 3.01±0.78 ** |
Note that the results are expressed as mean. + -. standard error, statistically processed by t-test, compared to the blank group, P < 0.05, P < 0.01, compared to the model group, △ P < 0.05, △△ P < 0.01.
As can be seen from Table 2, the amounts of 5-HT and Glu in the hypothalamus of rats of examples 1 to 3 in the administration group were decreased, the amount of GABA in the hypothalamus was increased, and the amount of Glu/GABA in the hypothalamus was decreased as compared with the model group, and at the same time, the examples and the comparative examples corresponding thereto showed that the amounts of change in the amounts of 5-HT, Glu and GABA in rats in the examples were larger than those in the comparative examples, i.e., the examples had a larger effect on the amounts of 5-HT, Glu and GABA in the hypothalamus of rats than those in the comparative examples.
Tables 1 and 2 show that the compound essential oil provided by the invention can affect the contents of neurotransmitters including 5-HT, Glu, GABA and the like in organisms, effectively regulate sleep and maintain mental stability, has the function of regulating sleep, and has the effect obviously superior to the effect of only adding the tangerine peel essential oil and the agilawood essential oil.
Compared with the prior art, the agilawood, the dried orange peel, the green tangerine peel, the radix bupleuri, the white paeony root and the gardenia in the compound essential oil provided by the invention are natural plants, and are safe, low in toxicity, less in side effect and free of drug resistance; the compound essential oil has flexible and various use modes; the essential oil has a small molecular structure, is easy to permeate skin and can accelerate absorption; compared with single-component essential oil, the compound essential oil provided by the invention complements each other and enhances the effect by utilizing the principle of different volatilization speeds of the essential oil in the formula on the basis of the compatibility theory of traditional Chinese medicines, so that the curative effect is enlarged, and the compound essential oil has the advantages of quick response, good curative effect and no wound by transdermal absorption; meanwhile, the preparation method provided by the invention is simple, convenient to operate, suitable for large-scale industrial production and high in production efficiency.
While the foregoing is directed to embodiments of the present invention, it will be understood by those skilled in the art that various changes may be made without departing from the spirit and scope of the invention.
Claims (7)
1. The composition for regulating sleep is characterized by comprising the following raw materials in parts by weight: 0.5 to 3 portions of dried orange peel, 0.5 to 3 portions of green tangerine orange peel, 0.6 to 3 portions of agilawood, 0.1 to 0.9 portion of bupleurum, 0.1 to 0.9 portion of white paeony root and 0.1 to 0.9 portion of gardenia.
2. The composition as claimed in claim 1, wherein the composition comprises the following raw materials and parts by weight thereof: 0.9 to 3 portions of dried orange peel, 0.9 to 2.1 portions of green tangerine orange peel, 0.9 to 2.1 portions of agilawood, 0.1 to 0.7 portion of bupleurum, 0.1 to 0.7 portion of white paeony root and 0.1 to 0.6 portion of gardenia.
3. The composition as claimed in claim 1, wherein the composition comprises the following raw materials and parts by weight thereof: 0.9 to 1.5 portions of dried orange peel, 0.9 to 1.5 portions of green tangerine orange peel, 0.9 to 1.5 portions of agilawood, 0.1 to 0.5 portion of bupleurum, 0.1 to 0.5 portion of white paeony root and 0.1 to 0.4 portion of gardenia.
4. A compound essential oil for regulating sleep, which comprises the composition for regulating sleep according to any one of claims 1 to 3.
5. The compound essential oil according to claim 4, wherein the use method of the compound essential oil comprises any one of aromatherapy sniffing, spraying, smearing and massaging.
6. The compound essential oil of claim 4, wherein the extraction method of the pericarpium citri reticulatae essential oil, the pericarpium citri reticulatae viride essential oil, the agilawood essential oil, the radix bupleuri essential oil, the radix paeoniae alba essential oil and the fructus gardeniae essential oil is one of steam distillation, squeezing, supercritical extraction, chemical solvent extraction, oil separation (liposuction), or immersion.
7. Use of a sleep regulating composition as claimed in any one of claims 1 to 3 in the field of traditional Chinese medicine, wherein the composition comprises any one of a sachet, a pillow, a medicated incense, a navel patch and a sachet.
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Effective date of registration: 20230117 Address after: 4-5/F, Building 1, Xinqizhou Public R&D Center, Chuangcheng, Department of Traditional Chinese Medicine, Ganjiang New District, Nanchang City, Jiangxi Province, 330000 Patentee after: Jiangxi Guxiang jinyunda Health Industry Co.,Ltd. Address before: 330004 No. 818 Xingwan Avenue, Wanli District, Nanchang City, Jiangxi Province Patentee before: JIANGXI University OF TRADITIONAL CHINESE MEDICINE |