CN112999105A - High-moisturizing essence lotion and preparation method thereof - Google Patents
High-moisturizing essence lotion and preparation method thereof Download PDFInfo
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- CN112999105A CN112999105A CN202110312481.XA CN202110312481A CN112999105A CN 112999105 A CN112999105 A CN 112999105A CN 202110312481 A CN202110312481 A CN 202110312481A CN 112999105 A CN112999105 A CN 112999105A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 51
- 239000006210 lotion Substances 0.000 title claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 86
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 39
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 30
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 28
- 230000014759 maintenance of location Effects 0.000 claims abstract description 18
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 16
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 16
- CLAHOZSYMRNIPY-UHFFFAOYSA-N 2-hydroxyethylurea Chemical compound NC(=O)NCCO CLAHOZSYMRNIPY-UHFFFAOYSA-N 0.000 claims abstract description 16
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 16
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims abstract description 16
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 16
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 16
- 229960003237 betaine Drugs 0.000 claims abstract description 16
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 16
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 16
- 229940031575 hydroxyethyl urea Drugs 0.000 claims abstract description 16
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract description 15
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 15
- 229920002498 Beta-glucan Polymers 0.000 claims abstract description 15
- 229960000458 allantoin Drugs 0.000 claims abstract description 15
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 14
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229940094944 saccharide isomerate Drugs 0.000 claims abstract description 11
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims description 35
- 239000000047 product Substances 0.000 claims description 23
- 238000001514 detection method Methods 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 15
- 239000012535 impurity Substances 0.000 claims description 13
- 238000004806 packaging method and process Methods 0.000 claims description 11
- 238000007599 discharging Methods 0.000 claims description 10
- 238000011049 filling Methods 0.000 claims description 8
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 7
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 7
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 5
- 230000002950 deficient Effects 0.000 claims description 5
- 230000000249 desinfective effect Effects 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 5
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- 235000015097 nutrients Nutrition 0.000 claims description 5
- 230000000704 physical effect Effects 0.000 claims description 5
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- 238000007789 sealing Methods 0.000 claims description 5
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- 239000007787 solid Substances 0.000 claims description 5
- 230000006641 stabilisation Effects 0.000 claims description 5
- 238000011105 stabilization Methods 0.000 claims description 5
- 238000003860 storage Methods 0.000 claims description 5
- 210000003491 skin Anatomy 0.000 abstract description 60
- 230000003020 moisturizing effect Effects 0.000 abstract description 24
- 230000000694 effects Effects 0.000 abstract description 12
- 102000011782 Keratins Human genes 0.000 abstract description 5
- 108010076876 Keratins Proteins 0.000 abstract description 5
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
- 230000007794 irritation Effects 0.000 abstract description 4
- 230000002045 lasting effect Effects 0.000 abstract description 3
- 230000035699 permeability Effects 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- ZXKXJHAOUFHNAS-FVGYRXGTSA-N (S)-fenfluramine hydrochloride Chemical compound [Cl-].CC[NH2+][C@@H](C)CC1=CC=CC(C(F)(F)F)=C1 ZXKXJHAOUFHNAS-FVGYRXGTSA-N 0.000 abstract description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract description 2
- 239000004472 Lysine Substances 0.000 abstract description 2
- 125000003277 amino group Chemical group 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 210000002510 keratinocyte Anatomy 0.000 abstract description 2
- 230000007246 mechanism Effects 0.000 abstract description 2
- 229920001542 oligosaccharide Polymers 0.000 abstract description 2
- 150000002482 oligosaccharides Chemical class 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 12
- 235000011187 glycerol Nutrition 0.000 description 11
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 230000037303 wrinkles Effects 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000002085 irritant Substances 0.000 description 4
- 231100000021 irritant Toxicity 0.000 description 4
- 241000282414 Homo sapiens Species 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 230000003266 anti-allergic effect Effects 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 239000002738 chelating agent Substances 0.000 description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000000428 dust Substances 0.000 description 3
- 230000002500 effect on skin Effects 0.000 description 3
- 230000001804 emulsifying effect Effects 0.000 description 3
- 210000001339 epidermal cell Anatomy 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 150000002484 inorganic compounds Chemical class 0.000 description 3
- 229910010272 inorganic material Inorganic materials 0.000 description 3
- 230000001050 lubricating effect Effects 0.000 description 3
- 231100000957 no side effect Toxicity 0.000 description 3
- 239000012466 permeate Substances 0.000 description 3
- 239000000419 plant extract Substances 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 230000037394 skin elasticity Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 230000000087 stabilizing effect Effects 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 210000000434 stratum corneum Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000037072 sun protection Effects 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 230000037314 wound repair Effects 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
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- 230000036555 skin type Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses essence water with high moisture retention and a preparation method thereof, and the technical scheme is as follows: the high-moisturizing essence water and the preparation method thereof have the beneficial effects that the high-moisturizing essence water comprises a component A and a component B, wherein the component A comprises water, hydroxyethyl urea, glycerol, p-hydroxyacetophenone, trehalose, allantoin and EDTA disodium, and the component B comprises betaine, water and saccharide isomerate, 1, 2-hexanediol, hydrolyzed hyaluronic acid and beta-glucan: the product of the invention adopts natural oligosaccharide high-efficiency moisturizing agent similar to skin, namely saccharide isomeride for moisturizing, has good skin-friendly property and strong permeability, plays the role of a high-efficiency moisture regulating factor by a unique association mechanism, further has long-acting water locking effect, is associated with free amino groups of lysine in keratinocyte keratin, is skin-friendly and not washed away, has high-efficiency moisturizing and no stickiness, and simultaneously combines the synergistic effect of a plurality of moisturizing agents to achieve high-efficiency lasting moisturizing effect without generating irritation and sticky feeling.
Description
Technical Field
The invention relates to the technical field of cosmetic production, and particularly relates to high-moisturizing essence water and a preparation method thereof.
Background
The essence water is a specific explanation of a certain water quality cosmetic skin care product, and shows that the product is different from a traditional common lotion, the product is more efficient, the essence water is between the common cleaning lotion and essence, compared with the common lotion, the essence water is not a common skin cleaning appeal any more, but a deeper repairing effect is achieved while the skin is moistened according to different skin qualities, the essence water is a skin care foundation, the daily requirement is larger, and the most popular essence water is a daily make-up and Korean make-up series.
The prior art has the following defects: although the essence water has a good maintenance effect, the essence water is not suitable for all skin types, most of the essence water in the current daily series and Korean series on the market has two defects, one is that most of the essence water contains alcohol, the moistening degree is not high, consumers of sensitive muscles and dry skin feel stabbing pain of the skin and even are drier, the skin affinity is not high, and long-acting water locking cannot be achieved.
Therefore, the invention is necessary to invent the essence water with high moisture retention and the preparation method thereof.
Disclosure of Invention
Therefore, the high-moisturizing essence water and the preparation method thereof provided by the invention can be used for moisturizing through saccharide isomerate, have good skin-friendly property and strong permeability, and simultaneously achieve high-efficiency and lasting moisturizing effects by combining the synergistic effect of the hydroxyethyl urea, the betaine, the hydrolyzed hyaluronic acid, the beta-glucan and the trehalose, and cannot generate irritation and sticky feeling, so that the problems in the background art are solved.
In order to achieve the above purpose, the invention provides the following technical scheme: the essence water with high moisture retention performance and the preparation method thereof comprise a component A and a component B, wherein the component A comprises water, hydroxyethyl urea, glycerol, p-hydroxyacetophenone, trehalose, allantoin and EDTA disodium, and the component B comprises betaine, water and saccharide isomer, 1, 2-hexanediol, hydrolyzed hyaluronic acid and beta-glucan.
Preferably, the component A comprises the following components in percentage by mass:
water: 90 to 92.2 percent
Hydroxyethyl urea: 4 to 5 percent
Glycerol: 1 to 2 percent
P-hydroxyacetophenone: 0.3 to 0.5 percent
Trehalose: 0.08 to 0.1 percent
Allantoin: 0.04 to 0.05 percent
Disodium EDTA: 0.04 to 0.05 percent.
Preferably, the components in the component B respectively account for the following total mass fractions:
betaine: 0.08 to 1 percent
Water and saccharide isomerate: 0.08 to 1 percent
1, 2-hexanediol: 0.45 to 0.5 percent
Hydrolysis of hyaluronic acid: 0.07-0.08 percent
Beta-glucan: 0.01 to 0.02 percent.
Preferably, the method also comprises the following preparation steps:
s1, firstly, respectively cleaning and disinfecting tools and equipment required to be used for preparation;
s2, grinding the component A into powder, and then adding the powder into a stirring pot to stir until the powder is completely dissolved;
s3, detecting, sampling the preparation in the stirring pot by using a clean and dry transparent beaker, and observing under sufficient illumination to ensure that the preparation in the beaker is transparent and clear without impurities and all solid components must be completely dissolved;
s4, adjusting the speed, stirring and cooling, when the temperature is reduced to 45-47 ℃, sequentially adding various nutrients and the component B, and then uniformly stirring;
s5, when the temperature is reduced to 38-40 ℃, detecting the preparation again, discharging the qualified product into a pre-sterilized storage container after the detection is qualified, sealing the container, and moving the container into a standing room for stabilization to be detected;
s6, the semi-finished product is inspected to be qualified, then is filled and packaged, and then is packaged, counted and warehoused;
and S7, the finished product can be delivered after being checked and qualified.
Preferably, the stirring is carried out in the S2 at a constant temperature of 75-85 ℃, and the stirring speed is 90-110 rev/min.
Preferably, the detection in S5 is a physical index detection, which detects whether the physical properties of the preparation reach the standard.
Preferably, the preparation needs to be filtered before discharging in the step S5, so that the preparation is transparent and clear and has no impurities.
Preferably, in the process from filling to packaging in S6, the product needs to be detected again in real time on-line to remove defective products.
The invention has the beneficial effects that:
the product of the invention adopts natural oligosaccharide high-efficiency moisturizing agent similar to skin, namely saccharide isomeride for moisturizing, has good skin-friendly property and strong permeability, plays a role of a high-efficiency moisture regulating factor by a unique association mechanism, further has long-acting water locking effect, is associated with free amino groups of lysine in keratinocyte keratin, is skin-friendly and not washed away, has high-efficiency moisturizing effect and is not sticky, and simultaneously combines the synergistic effect of the moisturizing agents of hydroxyethyl urea, betaine, hydrolyzed hyaluronic acid, beta-glucan and trehalose to achieve high-efficiency lasting moisturizing effect without generating irritation and sticky feeling.
Detailed Description
The following description of the preferred embodiments of the present invention is provided for the purpose of illustration and description, and is in no way intended to limit the invention.
Example 1:
the invention provides high-moisturizing essence water and a preparation method thereof, wherein the essence water comprises a component A and a component B, the component A comprises water, hydroxyethyl urea, glycerol, p-hydroxyacetophenone, trehalose, allantoin and EDTA disodium, and the component B comprises betaine, water and saccharide isomerate, 1, 2-hexanediol, hydrolyzed hyaluronic acid and beta-glucan;
further, the component A comprises the following components in percentage by mass:
water: 90 percent of water is an important resource for all life lives including inorganic compounds and human beings, and is also the most important component of organisms, and the water is used as a main solvent of the invention and is used for moistening the skin;
hydroxyethyl urea: 4 percent, hydroxyethyl urea is a micromolecule substance which absorbs water strongly, has excellent moisturizing performance, can help skin to lock water by combining with water molecules, has no sticky hand feeling, can permeate into cuticle, increases the water content of the skin, relieves dryness, fills fine wrinkles and increases the skin elasticity;
glycerol: 1%, glycerin has the water absorption function, can absorb water molecules in the air, forms a layer of protective film on the surface of the skin, protects the skin from being damaged by dust and impurities in the air, and keeps the skin moist for a long time;
p-hydroxyacetophenone: 0.3 percent, the p-hydroxyacetophenone is a plant extract, has excellent antiseptic property, very stable component property and no side effect on skin;
trehalose: 0.08 percent, the trehalose has stable property, is not easy to be damaged, has good effects on skin aging resistance, moisture retention, fatigue resistance, energy supplement, wound repair, sun protection and the like, has small molecular weight, is easy to be absorbed by the skin, can play unique functions when entering cells, and improves the anti-drying and anti-freezing capacity of the cells.
Allantoin: 0.04 percent, and the allantoin is mainly used for conditioning and protecting the skin, can help the skin to resist inflammation, relieve and promote cell repair, and simultaneously can reduce the adhesive force of stratum corneum cells and accelerate the renewal of epidermal cells.
Disodium EDTA: 0.04 percent, and the EDTA disodium is mainly used as a chelating agent in the invention, plays a stabilizing role and protects the skin from strong stimulation;
further, the components in the component B respectively account for the following total mass fractions:
betaine: 0.07 percent, the betaine has excellent moisture retention capacity, does not have sticky hand feeling when in use, and can make the skin surface smoother.
Water and saccharide isomerate: 0.08 percent of the total polysaccharide, the carbohydrate isomer can assist water to combine with keratin of the horny layer so as to achieve good moisturizing effect and can play a role in astringing pores.
1, 2-hexanediol: 0.45 percent of 1, 2-hexanediol has good antibacterial effect, has the functions of moistening skin and moisture, is mild and non-irritant, and can improve the skin-friendly feeling of the invention;
hydrolysis of hyaluronic acid: 0.07 percent, the hydrolyzed hyaluronic acid has excellent emulsifying, dispersing and moisturizing capabilities, and has the effects of moisturizing, nourishing, repairing, sun-screening, lubricating, film forming and the like on the skin;
beta-glucan: 0.01% of natural plant gum polysaccharide, has certain anti-allergic and anti-inflammatory effects, and can resist oxidation, protect skin from ultraviolet injury, reduce skin wrinkle, and improve skin ability to resist external injury
Further, the method also comprises the following preparation steps:
s1, firstly, respectively cleaning and disinfecting tools and equipment required to be used for preparation;
s2, grinding the component A into powder, adding the powder into a stirring pot for stirring until the powder is completely dissolved, and stirring at a constant temperature of 75 ℃ at a stirring speed of 90 rev/min;
s3, detecting, sampling the preparation in the stirring pot by using a clean and dry transparent beaker, and observing under sufficient illumination to ensure that the preparation in the beaker is transparent and clear without impurities and all solid components must be completely dissolved;
s4, adjusting the speed, stirring and cooling, when the temperature is reduced to 45 ℃, sequentially adding various nutrients and the component B, and then uniformly stirring;
s5, when the temperature is reduced to 38 ℃, detecting the preparation again, wherein the detection is physical index detection, detecting whether the physical property of the preparation reaches the standard, discharging the material into a pre-sterilized material storage container after the detection is qualified, sealing the container, moving the container into a standing room for stabilization and detection, and filtering the preparation before discharging to ensure that the preparation is transparent and clear without impurities;
s6, after the semi-finished product is inspected to be qualified, filling and packaging are started, then packaging, checking and warehousing are carried out, in the process from filling to packaging, real-time online detection needs to be carried out on the product again, and defective products are removed;
s7, the finished product can be delivered after being checked;
example 2:
the invention provides high-moisturizing essence water and a preparation method thereof, wherein the essence water comprises a component A and a component B, the component A comprises water, hydroxyethyl urea, glycerol, p-hydroxyacetophenone, trehalose, allantoin and EDTA disodium, and the component B comprises betaine, water and saccharide isomerate, 1, 2-hexanediol, hydrolyzed hyaluronic acid and beta-glucan;
further, the component A comprises the following components in percentage by mass:
water: 91%, water is an important resource for all life including inorganic compounds and human beings, and is also the most important component of organisms, and is used as the main solvent of the invention for moistening skin;
hydroxyethyl urea: 4.5 percent, the hydroxyethyl urea is a micromolecule substance which absorbs water strongly, has excellent moisture retention performance, can help skin to lock water by combining with water molecules, has no sticky hand feeling, can permeate into cuticle, increases the water content of the skin, relieves dryness, fills fine lines and increases the skin elasticity;
glycerol: 1.5 percent, the glycerin has the water absorption function, can absorb water molecules in the air, forms a layer of protective film on the surface of the skin, protects the skin from being damaged by dust and impurities in the air, and keeps the skin moist for a long time;
p-hydroxyacetophenone: 0.4 percent, the p-hydroxyacetophenone is a plant extract, has excellent antiseptic property, very stable component property and no side effect on skin;
trehalose: 0.09 percent, the trehalose has stable property, is not easy to be damaged, has good effects on skin aging resistance, moisture retention, fatigue resistance, energy supplement, wound repair, sun protection and the like, has small molecular weight, is easy to be absorbed by the skin, can play unique functions when entering cells, and improves the anti-drying and anti-freezing capacity of the cells.
Allantoin: 0.04 percent, and the allantoin is mainly used for conditioning and protecting the skin, can help the skin to resist inflammation, relieve and promote cell repair, and simultaneously can reduce the adhesive force of stratum corneum cells and accelerate the renewal of epidermal cells.
Disodium EDTA: 0.05 percent, and the disodium EDTA is mainly used as a chelating agent in the invention, has a stabilizing effect and protects the skin from strong stimulation;
further, the components in the component B respectively account for the following total mass fractions:
betaine: 0.09 percent, the betaine has excellent moisture retention capacity, does not have sticky hand feeling when in use, and can make the skin surface smoother.
Water and saccharide isomerate: 0.09%, the saccharide isomer can assist water to combine with keratin of horny layer, so as to achieve good moisturizing effect and astringe pores.
1, 2-hexanediol: 0.45 percent of 1, 2-hexanediol has good antibacterial effect, has the functions of moistening skin and moisture, is mild and non-irritant, and can improve the skin-friendly feeling of the invention;
hydrolysis of hyaluronic acid: 0.07 percent, the hydrolyzed hyaluronic acid has excellent emulsifying, dispersing and moisturizing capabilities, and has the effects of moisturizing, nourishing, repairing, sun-screening, lubricating, film forming and the like on the skin;
beta-glucan: 0.02% of natural plant collagen, beta-glucan with certain anti-allergic and anti-inflammatory effects, antioxidant effect, and can protect skin from ultraviolet injury, reduce skin wrinkle, and improve skin ability to resist external injury
Further, the method also comprises the following preparation steps:
s1, firstly, respectively cleaning and disinfecting tools and equipment required to be used for preparation;
s2, grinding the component A into powder, adding the powder into a stirring pot for stirring until the powder is completely dissolved, and stirring at a constant temperature of 75 ℃ at a stirring speed of 100 rev/min;
s3, detecting, sampling the preparation in the stirring pot by using a clean and dry transparent beaker, and observing under sufficient illumination to ensure that the preparation in the beaker is transparent and clear without impurities and all solid components must be completely dissolved;
s4, adjusting the speed, stirring and cooling, when the temperature is reduced to 46 ℃, sequentially adding various nutrients and the component B, and then uniformly stirring;
s5, when the temperature is reduced to 39 ℃, detecting the preparation again, wherein the detection is physical index detection, detecting whether the physical property of the preparation reaches the standard, discharging the material into a pre-sterilized material storage container after the detection is qualified, sealing the container, moving the container into a standing room for stabilization and detection, and filtering the preparation before discharging to ensure that the preparation is transparent and clear without impurities;
s6, after the semi-finished product is inspected to be qualified, filling and packaging are started, then packaging, checking and warehousing are carried out, in the process from filling to packaging, real-time online detection needs to be carried out on the product again, and defective products are removed;
and S7, the finished product can be delivered after being checked and qualified.
Example 3:
the invention provides high-moisturizing essence water and a preparation method thereof, wherein the essence water comprises a component A and a component B, the component A comprises water, hydroxyethyl urea, glycerol, p-hydroxyacetophenone, trehalose, allantoin and EDTA disodium, and the component B comprises betaine, water and saccharide isomerate, 1, 2-hexanediol, hydrolyzed hyaluronic acid and beta-glucan;
further, the component A comprises the following components in percentage by mass:
water: 92 percent, water is an important resource for all life lives including inorganic compounds and human beings, and is also the most important component of organisms, and is used as the main solvent of the invention for moistening the skin;
hydroxyethyl urea: 5 percent, hydroxyethyl urea is a micromolecule substance with strong water absorption effect, has excellent moisture retention performance, can help skin to lock water by combining with water molecules, has no sticky hand feeling, can permeate into cuticle, increases the water content of the skin, relieves dryness, fills fine wrinkles and increases the skin elasticity;
glycerol: 2 percent, the glycerin has the water absorption function, can absorb water molecules in the air, forms a layer of protective film on the surface of the skin, protects the skin from being damaged by dust and impurities in the air, and keeps the skin moist for a long time;
p-hydroxyacetophenone: 0.5 percent, the p-hydroxyacetophenone is a plant extract, has excellent antiseptic property, very stable component property and no side effect on skin;
trehalose: 0.1 percent, stable trehalose, not easy to be damaged, has good effects on skin aging resistance, moisture retention, fatigue resistance, energy supplement, wound repair, sun protection and the like, has small molecular weight, is easy to be absorbed by the skin, can play a unique function when entering cells, and improves the anti-drying and anti-freezing capacity of the cells.
Allantoin: 0.05 percent of allantoin, which is mainly used for conditioning and protecting the skin, can help the skin to resist inflammation, relieve and promote cell repair, and simultaneously, the allantoin can also reduce the adhesive force of stratum corneum cells and accelerate the renewal of epidermal cells.
Disodium EDTA: 0.05 percent, and the disodium EDTA is mainly used as a chelating agent in the invention, has a stabilizing effect and protects the skin from strong stimulation;
further, the components in the component B respectively account for the following total mass fractions:
betaine: 1 percent, the betaine has excellent moisturizing capability, does not have sticky hand feeling when in use, and can make the skin surface smoother.
Water and saccharide isomerate: 1 percent, the saccharide isomerate can assist water to combine with keratin of the horny layer so as to achieve good moisturizing effect and play a role in astringing pores.
1, 2-hexanediol: 0.5 percent of 1, 2-hexanediol has good antibacterial effect, has the functions of moistening skin and moisture, is mild and non-irritant, and can improve the skin-friendly feeling of the invention;
hydrolysis of hyaluronic acid: 0.08 percent, the hydrolyzed hyaluronic acid has excellent emulsifying, dispersing and moisturizing capabilities, and has the effects of moisturizing, nourishing, repairing, sun-screening, lubricating, film forming and the like on skin;
beta-glucan: 0.02% of natural plant collagen, beta-glucan with certain anti-allergic and anti-inflammatory effects, antioxidant effect, and can protect skin from ultraviolet injury, reduce skin wrinkle, and improve skin ability to resist external injury
Further, the method also comprises the following preparation steps:
s1, firstly, respectively cleaning and disinfecting tools and equipment required to be used for preparation;
s2, grinding the component A into powder, adding the powder into a stirring pot for stirring until the powder is completely dissolved, and stirring at the constant temperature of 85 ℃ at the stirring speed of 110 rev/min;
s3, detecting, sampling the preparation in the stirring pot by using a clean and dry transparent beaker, and observing under sufficient illumination to ensure that the preparation in the beaker is transparent and clear without impurities and all solid components must be completely dissolved;
s4, adjusting the speed, stirring and cooling, when the temperature is reduced to 47 ℃, sequentially adding various nutrients and the component B, and then uniformly stirring;
s5, when the temperature is reduced to 40 ℃, detecting the preparation again, wherein the detection is physical index detection, detecting whether the physical property of the preparation reaches the standard, discharging the material into a pre-sterilized material storage container after the detection is qualified, sealing the container, moving the container into a standing room for stabilization and detection, and filtering the preparation before discharging to ensure that the preparation is transparent and clear without impurities;
s6, after the semi-finished product is inspected to be qualified, filling and packaging are started, then packaging, checking and warehousing are carried out, in the process from filling to packaging, real-time online detection needs to be carried out on the product again, and defective products are removed;
and S7, the finished product can be delivered after being checked and qualified.
The finished product essence water prepared in the above examples 1-3 was selected from 30 female volunteers of 27-38 years old, and divided into three groups on average, and then the finished product essence water prepared in the above examples 1-3 was applied to the forearm twice a day for 7 days, and finally collected and arranged to obtain the following data:
according to the table, the high-moisturizing essence water prepared in the examples 1 to 3 has better performance in actual use, has very good moisturizing effect after use, long water-locking time, high skin activity, no stickiness, smooth skin, high-efficiency skin friendliness and no irritation when used, and is mild and non-irritant, wherein the high-moisturizing essence water prepared in the example 2 has the most excellent performance.
The above description is only a preferred embodiment of the present invention, and any person skilled in the art may modify the present invention or modify it into an equivalent technical solution by using the technical solution described above. Therefore, any simple modifications or equivalent substitutions made in accordance with the technical solution of the present invention are within the scope of the claims of the present invention.
Claims (8)
1. The essence lotion with high moisture retention comprises a component A and a component B, and is characterized in that: the component A comprises water, hydroxyethyl urea, glycerol, p-hydroxyacetophenone, trehalose, allantoin and EDTA disodium, and the component B comprises betaine, water and saccharide isomer, 1, 2-hexanediol, hydrolyzed hyaluronic acid and beta-glucan.
2. The essence lotion with high moisture retention according to claim 1, wherein: the component A comprises the following components in percentage by mass:
water: 90 to 92.2 percent
Hydroxyethyl urea: 4 to 5 percent
Glycerol: 1 to 2 percent
P-hydroxyacetophenone: 0.3 to 0.5 percent
Trehalose: 0.08 to 0.1 percent
Allantoin: 0.04 to 0.05 percent
Disodium EDTA: 0.04 to 0.05 percent.
3. The essence lotion with high moisture retention according to claim 1, wherein: the component B comprises the following components in percentage by mass:
betaine: 0.08 to 1 percent
Water and saccharide isomerate: 0.08 to 1 percent
1, 2-hexanediol: 0.45 to 0.5 percent
Hydrolysis of hyaluronic acid: 0.07-0.08 percent
Beta-glucan: 0.01 to 0.02 percent.
4. The method for preparing essence water with high moisture retention according to claim 1, wherein the method comprises the following steps: also comprises the following preparation steps:
s1, firstly, respectively cleaning and disinfecting tools and equipment required to be used for preparation;
s2, grinding the component A into powder, and then adding the powder into a stirring pot to stir until the powder is completely dissolved;
s3, detecting, sampling the preparation in the stirring pot by using a clean and dry transparent beaker, and observing under sufficient illumination to ensure that the preparation in the beaker is transparent and clear without impurities and all solid components must be completely dissolved;
s4, adjusting the speed, stirring and cooling, when the temperature is reduced to 45-47 ℃, sequentially adding various nutrients and the component B, and then uniformly stirring;
s5, when the temperature is reduced to 38-40 ℃, detecting the preparation again, discharging the qualified product into a pre-sterilized storage container after the detection is qualified, sealing the container, and moving the container into a standing room for stabilization to be detected;
s6, the semi-finished product is inspected to be qualified, then is filled and packaged, and then is packaged, counted and warehoused;
and S7, the finished product can be delivered after being checked and qualified.
5. The method for preparing essence water with high moisture retention according to claim 4, wherein the essence water comprises the following steps: and stirring at the constant temperature of 75-85 ℃ in the S2, wherein the stirring speed is 90-110 rev/min.
6. The method for preparing essence water with high moisture retention according to claim 4, wherein the essence water comprises the following steps: the detection in the S5 is physical index detection, and whether the physical property of the preparation reaches the standard is detected.
7. The method for preparing essence water with high moisture retention according to claim 4, wherein the essence water comprises the following steps: and the preparation needs to be filtered before discharging in the S5, so that the preparation is transparent and clear and has no impurities.
8. The method for preparing essence water with high moisture retention according to claim 4, wherein the essence water comprises the following steps: in the process from filling to packaging in S6, the product needs to be detected again on line in real time to remove defective products.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113693973A (en) * | 2021-10-09 | 2021-11-26 | 广州珈纳生物科技有限公司 | Double-layer essence lotion and preparation method thereof |
| CN114557900A (en) * | 2022-02-21 | 2022-05-31 | 广州盛妍精细化工有限公司 | Moisturizing lotion and preparation method thereof |
-
2021
- 2021-03-24 CN CN202110312481.XA patent/CN112999105A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 广州市迪笙生物科技有限公司: "《现代化妆品科学与技术 中》", 国家药品监督管理局 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113693973A (en) * | 2021-10-09 | 2021-11-26 | 广州珈纳生物科技有限公司 | Double-layer essence lotion and preparation method thereof |
| CN114557900A (en) * | 2022-02-21 | 2022-05-31 | 广州盛妍精细化工有限公司 | Moisturizing lotion and preparation method thereof |
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Application publication date: 20210622 |