CN110680786A

CN110680786A - Astaxanthin oil liposome composition and application thereof

Info

Publication number: CN110680786A
Application number: CN201911106290.7A
Authority: CN
Inventors: 魏升宁
Original assignee: Beijing Red Blue Cat Biotechnology Co Ltd
Current assignee: Beijing Red Blue Cat Biotechnology Co Ltd
Priority date: 2019-11-13
Filing date: 2019-11-13
Publication date: 2020-01-14

Abstract

The invention relates to the technical field of skin care products, in particular to an astaxanthin lipid liposome composition and application thereof. The invention provides an astaxanthin oil liposome composition, which comprises a component A, a component B and a component C; the component A comprises astaxanthin oil, phospholipid compounds, non-hormonal sterol steroids and polyhydric alcohols; the component B is a surfactant; the component C comprises a fat-soluble antioxidant, a water-soluble antioxidant, a skin penetrating agent, an effective component strengthening auxiliary agent and a skin nutrient; the mass ratio of the component A to the component B to the component C is (2-400): (0.4-1600): (5-2500). The astaxanthin lipidosome composition is applied to cosmetics and has the effects of resisting oxidation, removing wrinkles, resisting aging, repairing skin and the like.

Description

Astaxanthin oil liposome composition and application thereof

Technical Field

The invention relates to the technical field of skin care products, in particular to an astaxanthin lipid liposome composition and application thereof.

Background

ROS (reactive oxygen species) are the core cause of skin photodamage, and can cause oxidative damage to intracellular proteins, nucleic acids and the like; matrix Metalloproteinases (MMPs) are the very potent drugs that cause wrinkles, and MMPs can continuously damage collagen and elastin in the dermis, severely hampering the skin repair mechanism, causing uneven collapse of the epidermis, and forming wrinkles.

Astaxanthin, a carotenoid with the chemical name of 3,3' -dihydroxy-4, 4' -diketo-beta, beta ' -carotene, is a terpene-based unsaturated compound and is the highest-grade product of carotenoid synthesis. Astaxanthin is the most powerful antioxidant found in humans today. The astaxanthin has the capacity of scavenging free radicals which is 10 times that of lycopene, 100 times that of beta-carotene, 200 times that of lutein, 320 times that of tea polyphenol, 700 times that of anthocyanin, 1000 times that of vitamin E and 6000 times that of vitamin C. Astaxanthin has remarkable effects in scavenging free radicals, resisting oxidation, regulating matrix metalloproteinase, delaying aging, protecting cells, preventing ultraviolet irradiation, controlling inflammation, improving immunity, etc.

However, astaxanthin is a fat-soluble component, and is not easily taken into the skin, and it is difficult for astaxanthin to exert its intended effect.

Disclosure of Invention

The invention aims to provide an astaxanthin oil liposome composition and application thereof. The astaxanthin lipidosome composition can improve the effects of cosmetics on resisting oxidation and aging, reducing wrinkles, repairing ultraviolet injury, slowing down red blood streak, resisting inflammation, tendering skin, supplementing water, keeping moisture and locking water.

In order to achieve the above object, the present invention provides the following technical solutions:

the invention provides an astaxanthin oil liposome composition, which comprises a component A, a component B and a component C;

the component A comprises astaxanthin oil, phospholipid compounds, non-hormonal sterol steroids and polyhydric alcohols;

the component B is a surfactant;

the component C comprises a fat-soluble antioxidant, a water-soluble antioxidant, a skin penetrating agent, an effective component strengthening auxiliary agent and a skin nutrient;

the mass ratio of the component A to the component B to the component C is (2-400): (0.4-1600): (5-2500).

Preferably, the solvent of the astaxanthin oil is drying oil containing conjugate acid;

the drying oil containing conjugate acid is one or more of safflower oil, linseed oil, stubble oil, hemp seed oil, safflower oil, torreya seed oil, walnut oil, mustard oil and sunflower oil;

the mass concentration of the astaxanthin oil is 0.1-12%.

Preferably, the phospholipid compound is one or more of soybean lecithin, egg yolk lecithin, phosphatidylcholine, hydroxylated lecithin, hydrogenated soybean phospholipid, hydrogenated lecithin, cephalin, cardiolipin, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol, phosphatidic acid, phosphatidylethanolamine, lauroyl phosphatidylcholine, dimyristoyl phosphatidylcholine, dipalmitoyl phosphatidylglycerol, dipalmitoyl phosphatidic acid, dipalmitoyl phosphatidylethanolamine, distearoyl phosphatidylglycerol, distearoyl phosphatidylcholine, dioleoyl phosphatidylcholine and dioleoyl phosphatidylethanolamine;

the non-hormonal sterol is one or more of ergosterol, beta-sitosterol, squalene and vitamin D/provitamin D; the polyalcohol is one or more of propylene glycol, hexylene glycol, panthenol and butanediol.

Preferably, the weight ratio of the astaxanthin oil, the phospholipid compound, the non-hormonal sterol and the polyhydric alcohol in the component A is (1-42): (0.1-17): (0.005-3.33): (1-350).

Preferably, the fat-soluble antioxidant is one or more of guaiac resin, vitamin E, butyl hydroxy anisole, dibutyl hydroxy toluene, propyl gallate, tert-butyl hydroquinone, carotenoid and ubiquinone;

the water-soluble antioxidant is one or more of anthocyanin, vitamin C, flavonoid compound, phytic acid and disodium ethylene diamine tetraacetate.

Preferably, the skin penetrating agent is one or more of ethylhexyl isononanoate/pig ointment, glycerin, carbomer, glyceryl polyether, caprylic/capric triglyceride, isopropyl isostearate, n-butyl glycerol, polyethylene glycol and n-butanol.

Preferably, the efficacy component strengthening auxiliary comprises an antioxidant auxiliary, a skin care auxiliary and a skin moisturizer;

the antioxidant auxiliary agent is one or more of glutathione and/or coenzyme Q10;

the skin care auxiliary agent is one or more of pomegranate fruit extract, purslane extract, dendrobium officinale extract, ginseng extract, agrimony, dandelion extract, liquorice extract, sow thistle extract, aloe extract, honeysuckle extract, rhodiola rosea extract, rhododendron extract and mint extract;

the skin humectant is one or more of trehalose, beta-glucan, mannose, mannitol and inositol.

Preferably, the skin nutrient is one or more of xanthan gum, hyaluronic acid, sodium hyaluronate, collagen peptide, elastin, palmitoyl tripeptide-1, palm pentapeptide-4, hydroxyproline, proline, leucine, isoleucine and glycine.

Preferably, the mass ratio of the fat-soluble antioxidant to the water-soluble antioxidant to the skin penetrant to the functional component enhancing auxiliary agent to the skin nutritional agent is (0.01-30): (1-700): (1-1500): (2-200): (1-50).

The invention also provides application of the astaxanthin oil liposome composition in the technical scheme in cosmetics.

The invention provides an astaxanthin oil liposome composition, which comprises a component A, a component B and a component C; the component A comprises astaxanthin oil, phospholipid compounds, non-hormonal sterol steroids and polyhydric alcohols; the component B is a surfactant; the component C comprises a fat-soluble antioxidant, a water-soluble antioxidant, a skin penetrating agent, an effective component strengthening auxiliary agent and a skin nutrient; the mass ratio of the component A to the component B to the component C is (2-400): (0.4-1600): (5-2500). The astaxanthin oil liposome structure is formed by the functional components such as astaxanthin, antioxidant, skin nutrient and the like in the astaxanthin oil, the stability and percutaneous absorption capacity of the astaxanthin are improved by the liposome structure, and the components such as the astaxanthin and the like can rapidly permeate into a dermis layer and are retained in the skin to continuously repair skin tissues and cells. The astaxanthin enters skin cells, not only can play roles of eliminating ROS and regulating MMP, but also can generate synergistic effect with water-soluble antioxidant, fat-soluble antioxidant, skin nutrient and the like by utilizing the astaxanthin, so that the effects of oxidation resistance, wrinkle removal, aging resistance, skin repair and the like are greatly enhanced.

Drawings

FIG. 1 is a schematic diagram of the structure of the astaxanthin lipidosome;

fig. 2 is a schematic view showing the procedure of the cosmetic containing the astaxanthin lipidosome entering the skin.

Detailed Description

the component B is a surfactant;

In the present invention, all the raw material components are commercially available products well known to those skilled in the art unless otherwise specified.

In the present invention, the astaxanthin oil liposome composition comprises a component a; the component A comprises astaxanthin oil, phospholipid compounds, non-hormonal sterol steroids and polyhydric alcohols. In the present invention, the solvent for the astaxanthin oil is preferably a drying oil containing a conjugate acid; the drying oil containing conjugate acid is selected from one or more of safflower oil, oleum Lini, oleum Sesami, safflower oil, semen Torreyae oil, oleum Juglandis, mustard oil (poppy oil) and sunflower oil; when the drying oil containing the conjugate acid is more than two of the specific choices, the specific proportion of the specific substances is not limited in any way, and the drying oil containing the conjugate acid can be mixed according to any proportion. In the present invention, the mass concentration of the astaxanthin oil is preferably 0.1 to 12%, more preferably 2 to 10%, and most preferably 4 to 6%.

In the present invention, the phospholipid compound is preferably one or more selected from soybean lecithin, egg yolk lecithin, phosphatidylcholine, hydroxylated lecithin, hydrogenated soybean phospholipid, hydrogenated lecithin, cephalin, cardiolipin, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol, phosphatidic acid, phosphatidylethanolamine, lauroyl phosphatidylcholine, dimyristoyl phosphatidylcholine, dipalmitoyl phosphatidylglycerol, dipalmitoyl phosphatidic acid, dipalmitoyl phosphatidylethanolamine, distearoyl phosphatidylglycerol, distearoyl phosphatidylcholine, dioleoyl phosphatidylcholine and dioleoyl phosphatidylethanolamine; when the phospholipid compound is two or more of the above specific choices, the specific material ratio is not particularly limited, and the phospholipid compound may be mixed at any ratio.

In the invention, the sterol is preferably one or more of ergosterol, beta-sitosterol, squalene, vitamin D/provitamin D; when the non-hormonal steroid sterol is more than two of the above specific choices, the specific material proportion is not limited in any way, and the non-hormonal steroid sterol and the specific material can be mixed according to any proportion.

In the present invention, the polyhydric alcohol is preferably one or more selected from propylene glycol, hexylene glycol, panthenol and butylene glycol, and when the polyhydric alcohol is two or more selected from the above specific choices, the specific ratio of the specific substances in the present invention is not particularly limited, and the specific substances may be mixed in any ratio.

In the invention, the weight ratio of the astaxanthin oil, the phospholipid compound, the non-hormonal sterol steroid and the polyhydric alcohol in the component A is preferably (1-42): (0.1-17): (0.005-3.33): (1-350), more preferably (5-35): (3-14): (0.1-3.0): (20-280), most preferably (10-20): (5-10): (0.6-2.0): (50-150).

In the present invention, five parts of the solvent, phospholipid compound, non-hormonal sterol, polyol and surfactant of the B-component in the astaxanthin oil together constitute the wall material (sterol and PEG layer shown in fig. 1) of the astaxanthin oil liposome composition. The function is to dissolve fat-soluble components such as astaxanthin and the like and form oleophilic first layer and second layer of astaxanthin oil liposome.

In the present invention, the astaxanthin oil liposome further comprises a component B, which is preferably a surfactant; the surfactant is preferably one or more of cetearyl glucoside, sorbitan stearate, glycerol stearate, cetearyl alcohol, polyacrylate-13, polymethylsiloxane, polydimethylsiloxane, polyisobutylene, and polysorbate-20 and polysorbate-80; when the surfactants are more than two of the above specific choices, the invention does not have any special limitation on the proportion of the specific substances, and the specific substances can be mixed according to any proportion.

In the present invention, the surfactant functions as an emulsifier, and also as a bridging agent for the fat-soluble component and the water-soluble component, and constitutes the third layer of the astaxanthin oil liposome.

In the invention, the astaxanthin oil liposome also comprises a C component, wherein the C component comprises a fat-soluble antioxidant, a water-soluble antioxidant, a skin penetrating agent, an effective component strengthening auxiliary agent and a skin nutrient.

In the invention, the fat-soluble antioxidant is preferably one or more of guaiac resin, VE, butyl hydroxy anisole, dibutyl hydroxy toluene, propyl gallate, tert-butyl hydroquinone, carotenoid and ubiquinone; when the fat-soluble antioxidant is more than two of the specific choices, the specific proportion of the specific substances is not limited in any way, and the specific substances can be mixed according to any proportion.

In the present invention, the fat-soluble antioxidant constitutes the first layer part of the liposome (oil phase solution as shown in fig. 1).

In the invention, the water-soluble antioxidant is preferably one or more of anthocyanin, vitamin C, flavonoid, phytic acid and disodium ethylene diamine tetraacetate; when the water-soluble antioxidant is more than two of the specific choices, the specific proportion of the specific substances is not limited in any way, and the specific substances can be mixed according to any proportion.

In the present invention, the water-soluble antioxidant constitutes the 5 th part of the liposome (the aqueous solution part as shown in fig. 1).

In the invention, the fat-soluble antioxidant and the water-soluble antioxidant respectively act as fat-soluble and water-soluble reducing agents in the life metabolism to form a complete reducing agent system, so that the reducing reaction in the life metabolism of the astaxanthin is supplemented, and the reducing reaction is slow or can not take place.

In the present invention, the skin penetrating agent is preferably one or more of ethylhexyl pelargonate/pig ointment, glycerin, carbomer, glyceryl polyethers (such as glyceryl polyether-26, 31), caprylic/capric triglyceride, isopropyl isostearate, n-butyl glycerol and n-butanol; when the skin penetrating agent is more than two of the specific choices, the proportion of the specific substances is not limited in any way, and the specific substances can be mixed according to any proportion.

In the present invention, the skin penetrating agent constitutes the fourth layer portion of the liposome (e.g., the co-solvent, skin penetrating agent, etc. shown in fig. 1) and functions to aid in penetration of the liposome into the skin.

In the invention, the efficacy component strengthening auxiliary comprises an antioxidant auxiliary, a skin care auxiliary and a skin humectant; in the invention, the mass ratio of the antioxidant auxiliary agent to the skin care auxiliary agent to the skin moisturizer is preferably (1-10): (1-20): (1-100), more preferably (2-8): (5-15): (20-90), most preferably (4-6): (8-12): (50-70). In the invention, the antioxidant auxiliary agent is preferably one or more of glutathione and coenzyme Q10; when the antioxidant auxiliary agents are more than two of the specific choices, the specific proportion of the specific substances is not limited in any way, and the specific substances are mixed according to any proportion. In the invention, the skin care auxiliary agent is preferably one or more of pomegranate fruit extract, purslane extract, dendrobium officinale extract, ginseng extract, agrimony, dandelion extract, liquorice extract, sow thistle extract, aloe extract, honeysuckle extract, rhodiola rosea extract, rhododendron extract and mint extract; when the skin care auxiliary agent is more than two of the specific choices, the proportion of the specific substances is not limited in any way, and the specific substances can be mixed according to any proportion. In the invention, the skin moisturizer is preferably one or more of trehalose, beta-glucan, mannose, mannitol and inositol; when the skin moisturizer is more than two of the above specific choices, the present invention does not have any particular limitation on the ratio of the specific substances.

In the present invention, the efficacy component enhancement adjuvant constitutes the 5 th part of the liposome (as shown in fig. 1 as an aqueous solution) and has the functions of strengthening electron transfer chains, enhancing the function of a reducing agent in life metabolism, moisturizing skin and conditioning skin physiological state.

In the invention, the skin nutrient is preferably one or more of xanthan gum, hyaluronic acid (sodium), collagen peptide, elastin, palmitoyl tripeptide-1, palm pentapeptide-4, hydroxyproline, proline, leucine, isoleucine and glycine; when the skin nutrient is more than two of the specific choices, the invention has no special limitation on the proportion of the specific substances and can mix the specific substances according to any proportion.

In the invention, the skin nutrient and astaxanthin can form a water-soluble coupling compound, thereby greatly enhancing the repairing effect of the damage of the collagen fiber and elastic fiber net structure of the skin caused by oxidation, ultraviolet rays and the like.

In the invention, the mass ratio of the fat-soluble antioxidant, the water-soluble antioxidant, the skin penetrant, the functional component enhancing auxiliary agent and the skin nutrient is preferably (0.01-30): (1-700): (1-1500): (3-950): (1-50), more preferably (0.1-25): (10-600): (100-1000): (100-800): (5-45), most preferably (2-20): (20-500): (200-800): (300-700): (8-30).

In the invention, the mass ratio of the component A, the component B and the component C is preferably (2-400): (0.4-1600): (5-2500), more preferably (5-300): (100-1200): (100-2000), most preferably (30-100): (300-1000): (500-1000).

In the present invention, the astaxanthin oil liposome composition does not need to be separately prepared, and is involved in the process of preparing the cosmetics according to a certain adding sequence when being applied to the cosmetics. The specific process is described in the following about the preparation process of the astaxanthin oil liposome composition when the composition is applied to cosmetics.

In the present invention, the cosmetic comprises an astaxanthin oil liposome composition, a processability improver and water; the mass ratio of the astaxanthin oil liposome composition to the processing property modifier to the water is preferably (1.5-30) to (0.25-15): (60-95), more preferably (5-25) and (1-10): (65-90), most preferably (10-22): (3-8): (70-85).

In the invention, the processing property modifier preferably comprises one or more of essence, preservative, metal ion chelating agent, pH regulator, modifier and thickener; in the invention, the preservative is preferably one or more of p-hydroxyacetophenone, caprylyl hydroxamic acid, paraben compounds, benzoic acid, sodium benzoate, phenoxyethanol, benzyl alcohol and C3-7 monohydric alcohol; when the preservative is more than two of the above specific choices, the proportion of the specific substances is not limited in any way, and the specific substances can be mixed according to any proportion.

In the present invention, the metal ion chelating agent is preferably one or more selected from disodium EDTA and/or tetrasodium iminodisuccinate, and when the metal ion chelating agent is two or more selected from the above specific choices, the ratio of the specific substances in the present invention is not particularly limited, and the specific substances may be mixed in any ratio.

In the present invention, the pH adjusting agent is preferably triethanolamine and/or sodium citrate salt; when the pH regulator is more than two of the specific choices, the proportion of the specific substances is not limited in any way, and the specific substances can be mixed according to any proportion.

In the invention, the thickening agent is preferably one or more of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, hydroxymethyl cellulose and hydroxyethyl cellulose; when the thickening agents are more than two of the specific choices, the proportion of the specific substances is not limited in any way, and the specific substances can be mixed according to any proportion.

In the present invention, the components of the cosmetic are preferably classified according to the following principles: according to the components of the cosmetic, the cosmetic is divided into a hydrophilic component and a lipophilic component; the hydrophilic component is divided into a component which can stably exist at the temperature of 60-85 ℃ and a component which cannot stably exist at the temperature of 60-85 ℃ according to whether the hydrophilic component can stably exist in an aqueous solution at the temperature of 60-85 ℃. Based on the principle that the surfactant is divided into hydrophilic surfactant (HLB is more than 10) and lipophilic surfactant (HLB is less than 10) according to the limit that the hydrophilic-lipophilic value is 10, the invention also ensures that the preparation raw materials are not lost or are lost as little as possible in the preparation process so as to ensure that the preparation raw materials exert the application functionality.

In the present invention, the preparation method of the cosmetic preferably comprises the steps of:

1) mixing a C component capable of stably existing in an aqueous solution at a temperature of 60-85 ℃, a processing property modifier capable of stably existing in an aqueous solution at a temperature of 60-85 ℃, a hydrophilic surfactant, polyol and part of water, and performing bus sterilization at a temperature of 60-85 ℃ for 30min to obtain a first mixture;

2) mixing the astaxanthin solution, phospholipid compound and/or sterol to obtain mixture containing astaxanthin oil;

3) mixing the lipophilic C component, the lipophilic processing property modifier and the lipophilic surfactant, mixing with a mixture containing astaxanthin oil, and performing bus sterilization at the temperature of 60-85 ℃ to obtain a second mixture;

4) mixing hydrophilic surfactant with water, stirring for emulsifying, and pasteurizing at 80 deg.C for 30min to obtain emulsifier;

5) mixing a C component which is unstable in a water phase at a temperature of 60-85 ℃, a processing property modifier which is unstable in the water phase at a temperature of 60-85 ℃, a hydrophilic surfactant and part of water at 45 ℃ to obtain a third mixture for later use;

6) stirring the first mixture in a vacuum pan to remove oxygen, slowly adding the second mixture for 3 hours, and then adding an emulsifier; adding the third mixture at 45 deg.C, stirring, standing for 30min, detecting according to production standard, and packaging to obtain astaxanthin oil liposome cosmetic.

In the invention, the cosmetic containing the astaxanthin oil liposome composition permeates skin in a process of (1) the transdermal absorption of liposome is realized by increasing the humidification and hydration of stratum corneum, the transdermal penetration of the medicine wrapped by the liposome is obviously influenced by the amounts of phospholipid component and cholesterol in the liposome, and the closer the polarity of lipid in the prescription is to the skin, the more favorable the medicine penetrates the stratum corneum. (2) The arrangement of the hydrophobic tail parts in the two layers of the horny cell is disordered by changing the structure of the horny cell, and the components enter the intercellular substance through the diffusion and other actions. The mobile unsaturated Phospholipids (PC) greatly enhance the fluidity of stratum corneum lipids. The stratum corneum lipid fluidity is enhanced, and the functional ingredients can be remarkably promoted to enter the stratum corneum of the skin. (3) The liposome forms a reservoir of effective components in epidermis and dermis, and is slowly released to improve skin for a long time (as shown in figure 2).

The astaxanthin lipid liposome composition and the use thereof according to the present invention will be described in detail with reference to examples, but they should not be construed as limiting the scope of the present invention.

Example 1

Astaxanthin lipid mask essence:

astaxanthin liposome composition:

the component A comprises: astaxanthin oil (0.02 g): the solvent is safflower oil; the mass concentration of the astaxanthin is 5 percent;

phospholipid compounds: soybean lecithin (0.00002 g);

steroid sterols: beta-sitosterol (0.02 g);

polyol: butanediol (0.3g), propylene glycol (2g), butanediol (3g), hexanediol (0.3 g);

and B component: surfactant (1.2 g): cetearyl glucoside (0.3g), sorbitan stearate (0.1g), glyceryl stearate (0.1g), cetearyl alcohol (0.1g), polyacrylate-13 (0.2g), polyisobutylene (0.1g), polysorbate-20 (0.3 g);

and C, component C: fat-soluble antioxidant: VE (0.00002 g);

water-soluble antioxidant: soy isoflavones (3 g);

skin penetrant: glycerin (5g), glyceryl polyether-26 (0.1g), ethylhexyl isononanoate/pig ointment (1g), carbomer (0.15g), PEG-40 hydrogenated castor oil (0.2 g);

functional component strengthening auxiliary agent: antioxidant auxiliary agent: glutathione (0.03 g);

skin care agents: purslane extract (0.3g), dendrobium officinale extract (0.1g), pomegranate fruit extract (0.1 g);

skin moisturizing agent: trehalose (5g), β -glucan (4 g);

skin nutrient: sodium hyaluronate (0.1g), collagen peptide (0.05g), palmitoyl tripeptide-1 (0.2 g);

the processing property modifier is as follows:

essence: essence (0.001 g);

preservative: p-hydroxyacetophenone (0.2 g);

metal ion chelating agent: disodium EDTA (0.01 g);

pH regulator: triethanolamine (0.15 g);

thickening agent: acrylic/C10-30 Alkanolacrylate crosspolymer (0.03 g);

water: 82.57 g;

mixing glycerol, trehalose, butanediol, sodium hyaluronate, glyceryl polyether-26, p-hydroxyacetophenone, collagen peptide, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, EDTA disodium and 35g of water, and carrying out pasteurization at 60-85 ℃ for 30min to obtain a first mixture;

mixing VE, soybean lecithin, beta-sitosterol and astaxanthin oil to obtain a mixture containing astaxanthin oil;

mixing ethylhexyl isononanoate/lard, cetearyl glucoside, sorbitan stearate, glyceryl stearate and cetearyl alcohol, mixing with the mixture containing astaxanthin oil, and pasteurizing at 80 deg.C for 30min to obtain a second mixture; mixing polyacrylate-13, 20g water, polyisobutylene, polysorbate-20 and triethanolamine, stirring for emulsification, and pasteurizing at 80 deg.C for 30min to obtain emulsifier;

mixing herba Portulacae extract, herba Dendrobii extract, soybean isoflavone, fructus Punicae Granati extract, glutathione, beta-dextran, polysorbate-20, carbomer, palmitoyl tripeptide-1, essence, PEG-40 hydrogenated castor oil, propylene glycol, butanediol, hexanediol and 27.57g water at 45 deg.C to obtain a third mixture;

stirring the first mixture in a vacuum pan to remove oxygen, and slowly adding the second mixture for 3 hours; then adding an emulsifier; adding the third mixture at 45 deg.C, stirring, and standing for 30 min.

And detecting according to the standard requirements of the produced mask, and filling to obtain the astaxanthin lipidosome mask essence.

Example 2

Astaxanthin oil liposome cream:

astaxanthin liposome composition:

the component A comprises: astaxanthin oil (1 g): the solvent is safflower oil; the mass concentration of the astaxanthin is 0.1%;

steroid sterols: beta-sitosterol (0.002 g);

polyol: panthenol (0.1g), butanediol (3.3g), propylene glycol (7g), hexylene glycol (0.1 g);

and B component: surfactant (b): cetearyl glucoside (0.2g), cetearyl alcohol (0.5g), polymethylsiloxane (1g), polydimethylsiloxane (1g), glyceryl stearate (3g), polyacrylate-13 (0.2g), polyisobutylene (0.3g), polysorbate-80 (1 g);

and C, component C: fat-soluble antioxidant: VE (0.1 g);

water-soluble antioxidant: soy isoflavones (3 g);

skin penetrant: glycerol (5g), glyceryl polyether-26 (1g), glyceryl polyether-31 (1g), ethyl isononanoate (0.5g), carbomer (0.2g), PEG-100 hydrogenated castor oil (2g) caprylic triglyceride (1.5g), isopropyl isostearate (0.2 g);

functional component strengthening auxiliary agent: antioxidant auxiliary agent: glutathione (0.1 g);

skin care agents: purslane extract (0.2g), ginseng extract (0.2g), pomegranate fruit extract (0.2 g);

skin moisturizing agent: trehalose (5g), β -glucan (4 g);

skin nutrient: hydroxyproline (0.02g), palm pentapeptide-4 (0.2g), sodium hyaluronate (0.5g) and collagen peptide (0.1 g);

the processing property modifier is as follows:

essence: essence (0.01 g);

preservative: p-hydroxyacetophenone (0.2 g);

metal ion chelating agent: disodium EDTA (0.01 g);

pH regulator: triethanolamine (0.12 g);

thickening agent: acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer (2 g);

water: (62.16 g);

mixing hydroxyproline, glycerol, panthenol, butanediol, propylene glycol, sodium hyaluronate, glyceryl polyether-26, p-hydroxyacetophenone, collagen peptide, acrylic acid/C10-30 alkanol acrylate cross-linked polymer, EDTA disodium and 25g of water, and pasteurizing at 83 deg.C for 30min to obtain a first mixture;

mixing VE, beta-sitosterol and astaxanthin oil to obtain a mixture containing astaxanthin oil;

mixing glyceryl polyether-31, caprylic triglyceride, isopropyl isostearate, ethylhexyl isononanoate, cetearyl glucoside, cetearyl alcohol, polymethylsiloxane, polydimethylsiloxane and glyceryl stearate, mixing with the mixture containing astaxanthin oil, stirring for emulsification, and pasteurizing at 83 deg.C for 30min to obtain a second mixture for use;

mixing polyacrylate-13, 17.2g water, polyisobutylene, polysorbate-80 and triethanolamine, and pasteurizing at 83 deg.C for 30min to obtain emulsifier;

mixing herba Portulacae extract, Ginseng radix extract, soybean isoflavone, fructus Punicae Granati extract, glutathione, dextran, polysorbate-20, carbomer, palm pentapeptide-4, essence, PEG-100 hydrogenated castor oil, propylene glycol, butanediol, hexanediol and g water at 45 deg.C to obtain a third mixture;

stirring the first mixture in a vacuum pan to remove oxygen, and slowly adding the second mixture for 3 hours; then adding an emulsifier; adding the third mixture at 45 deg.C, stirring, standing for 30min, detecting according to standard requirements of facial mask, and packaging to obtain astaxanthin oil liposome cream.

Example 3

Astaxanthin oil liposome essence:

astaxanthin liposome composition:

the component A comprises: astaxanthin oil (0.2 g): the solvent is safflower oil, and the mass concentration is 0.5%;

steroid sterols: beta-sitosterol (0.002 g); soybean lecithin (0.01 g);

polyol: panthenol (0.1g), butanediol (0.5g), propylene glycol (1g), hexylene glycol (0.2 g);

and B component: surfactant (b): polyacrylate-13 (0.2g), polyisobutylene (0.2g), polysorbate-80 (0.1g), polysorbate-20 (0.3g), glyceryl stearate (0.3g), cetostearyl alcohol (0.2g)

And C, component C: fat-soluble antioxidant: VE (0.02 g);

water-soluble antioxidant: soy isoflavones (7 g);

skin penetrant: glycerol (6g), glyceryl polyether-26 (0.15g), ethyl isononanoate/lard (0.2g), carbomer (0.2g), PEG-100 hydrogenated castor oil (3 g);

functional component strengthening auxiliary agent: antioxidant auxiliary agent: glutathione (0.1g)

Skin care agents: mixing herba Portulacae extract (0.2g), herba Dendrobii extract (0.1g), fructus Punicae Granati extract (0.2g), and radix Rhodiolae extract (0.2 g);

skin moisturizing agent: trehalose (2g), mannose (2g), β -glucan (2 g);

skin nutrient: hydroxyproline (0.02g), palmitoyl tripeptide-1 (0.2g), sodium hyaluronate (0.3g), collagen peptide (0.3 g);

the processing property modifier is as follows:

essence: essence (0.01 g);

preservative: p-hydroxyacetophenone (0.2g), sodium benzoate 0.3 g;

metal ion chelating agent: disodium EDTA (0.01 g);

pH regulator: triethanolamine (0.12 g);

thickening agent: acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer (3 g);

water: (68.86 g);

dissolving VE, soybean lecithin, and beta-sitosterol in astaxanthin oil to obtain a first mixture;

taking ethylhexyl isononanoate/pig ointment, glyceryl stearate, cetostearyl alcohol and 15g of water as a second mixture, emulsifying the second mixture with the first mixture, uniformly mixing, deoxidizing in a vacuum pan, heating to 60-85 ℃, carrying out pasteurization for 30min, and cooling to below 45 ℃ for later use;

dissolving glycerin, trehalose, beta-glucan, mannose, sodium hyaluronate, glyceryl polyether-26, sodium benzoate, collagen peptide, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, polyisobutylene, EDTA disodium, polysorbate-20, polysorbate-80, propylene glycol, butanediol, hexanediol and 30g of water to obtain a third mixture, deoxidizing in a vacuum pan, heating to 60-85 ℃, carrying out pasteurization for 30min, and cooling to 45 ℃ for later use;

dissolving p-hydroxyacetophenone, a purslane extract, a ginseng dendrobium extract, soybean isoflavone, a pomegranate fruit extract, a rhodiola rosea extract, glutathione, hydroxyproline, carbomer, palmitoyl tripeptide-1, essence and 3g of PEG-40 hydrogenated castor oil in 23.9g of water, using an aqueous solution below 45 ℃ as a fourth mixture, deoxidizing in a vacuum pan, heating to 60-85 ℃, sterilizing for 30min by using a bus, and cooling to 45 ℃ for later use; .

Stirring the third mixture in a vacuum pan to remove oxygen, slowly adding the first mixture and the second mixture, and then adding an emulsifier; adding the fourth mixture at 45 deg.C, stirring, and standing for 30 min.

Dissolving 1.2g triethanolamine in 5g sterilized water, deoxidizing in a vacuum pan, heating to 60-85 deg.C, pasteurizing for 30min, cooling to 45 deg.C, and adjusting pH to 6.5-6.8.

And (4) detecting and filling according to QB/T2872 standard requirements to obtain astaxanthin oil liposome essence.

Example 4

Astaxanthin oil liposome skin care emulsion:

astaxanthin liposome composition:

the component A comprises: astaxanthin oil (1 g): the solvent is safflower oil, the mass concentration is 0.1%;

steroid sterols: soybean lecithin (0.02g), beta-sitosterol (0.003 g);

polyol: butanediol (0.2g), propylene glycol (0.5g), hexanediol (0.2 g);

and B component: surfactant (b): polyacrylate-13 (0.2g), polyisobutylene (0.2g), polysorbate-80 (0.1g), polysorbate-20 (0.1g), glyceryl stearate (0.4g), cetostearyl alcohol (0.3g)

And C, component C: fat-soluble antioxidant: tocopheryl acetate (0.05 g);

water-soluble antioxidant: soy isoflavones (5 g);

skin penetrant: glycerin (6g), glyceryl polyether-26 (0.1g), ethylhexyl isononanoate/pig ointment (0.2g), carbomer (0.1g), PEG-40 hydrogenated castor oil (0.2 g);

Skin care agents: mixing herba Portulacae extract (0.2g), herba Dendrobii extract (0.1g), fructus Punicae Granati extract (0.1g), and Aloe extract (0.2 g);

skin moisturizing agent: trehalose (2g), mannose (2g), β -glucan (2 g);

skin nutrient: palmitoyl tripeptide-1 (0.1g), sodium hyaluronate (0.2g), collagen peptide (0.1 g);

the processing property modifier is as follows:

essence: essence (0.001 g);

preservative: p-hydroxyacetophenone (0.2g), sodium benzoate (0.3 g);

metal ion chelating agent: disodium EDTA (0.01 g);

pH regulator: triethanolamine (0.12 g);

thickening agent: acrylic/C10-30 Alkanolacrylate crosspolymer (0.03 g);

water: (77.4 g);

tocopherol acetate, soybean lecithin, beta-sitosterol were dissolved in astaxanthin oil (safflower oil solvent, astaxanthin concentration 0.1%) as a first mixture for use.

Mixing ethylhexyl isononanoate/lard, glyceryl stearate, cetostearyl alcohol, glyceryl polyether-26 and astaxanthin oil prepared in the step (1), adding 5g of water for emulsification to obtain a second mixture, uniformly stirring, deoxidizing in a vacuum pan, heating to 60-85 ℃, pasteurizing for 30min, and cooling to 45 ℃ for later use;

dissolving glycerin, trehalose, mannose, beta-glucan, sodium hyaluronate, sodium benzoate, collagen peptide, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, EDTA disodium, polyacrylate-13, polyisobutylene, polysorbate-80, polysorbate-20, butanediol, propylene glycol, hexanediol and sodium hyaluronate with 35g of water to obtain a third mixture, deoxidizing in a vacuum pan, heating to 60-85 ℃, pasteurizing for 30min, and cooling to below 45 ℃ for later use;

taking p-hydroxyacetophenone, purslane extract, ginseng extract, soybean isoflavone, pomegranate fruit extract, aloe extract, glutathione, carbomer, palm tripeptide-1, essence, PEG-40 hydrogenated castor oil and 37.4g of aqueous solution as a fourth mixture, deoxidizing in a vacuum pan, heating to 60-85 ℃, pasteurizing for 30min, and cooling to 45 ℃ for later use;

And detecting and filling according to QB/T2872 standard requirements to obtain the astaxanthin oil liposome skin care milk.

Test example

The astaxanthin lipid body mask of example 1, the astaxanthin lipid body cream of example 2, the astaxanthin lipid body essence of example 3, and the astaxanthin lipid body skin care cream of example 4 were each subjected to a test in 40 cases:

1. object

40 volunteers aged 30-50 years were randomly selected for female testing, and 40 volunteers were all persons who used skin care products frequently. Volunteers were randomly divided into 4 groups, numbered 1 (oily skin group), 2 (dry skin group), 3 (mixed skin group), 4 (sensitive skin group), 10 persons each. The selected volunteers have the symptoms of fine lines and wrinkles on the face, accompanied with relaxation, low skin immunity, easy allergy, certain skin injury (ultraviolet sunburn, red blood streak, inflammation and the like), rough skin, large pores and poor skin dryness and water retention.

2. Method of producing a composite material

The volunteers in groups 1, 2, 3 and 4 used the astaxanthin lipid body mask in example 1, the astaxanthin lipid body cream in example 2, the astaxanthin lipid body essence in example 3 and the astaxanthin lipid body cream in example 4 every two to three days in the morning or after cleansing at night, the dosage of each time was 2g or 4g, the trial period was 30 days, and the testers stopped using the product with the same effect in the 30 days.

And (4) testing a grading standard: for improving fine lines and relieving skin looseness; repairing skin, and relieving allergy; tendering skin and reducing pores; skin care product repair time; moisture preservation and water locking; scoring the six aspects of safety and irritation, wherein each item is full of 5 points; taking the average score of each volunteer as a single test result, and finally adding the total scores of the four skin groups to obtain an average value, namely a product total score; the scoring criteria are set forth in table 1:

TABLE 1 Scoring standards

The test results are shown in tables 2-5:

TABLE 2 oily skin group

TABLE 3 Dry skin texture group

TABLE 4 Mixed skin texture group

TABLE 5 sensitive skin texture group

TABLE 6 Total points

The embodiment shows that the anti-aging cosmetic provided by the invention has remarkable effects of improving fine lines, relieving skin looseness, repairing skin, slowing down allergic state, tendering skin, shrinking pores, enhancing skin moisture retention and locking water, has small irritation and high safety, and is an excellent skin care product with long skin repairing time.

The present invention has been described above by way of example with reference to specific embodiments, and the specific implementation is not limited by the above-mentioned manner, and it is within the scope of the present invention to modify the idea and technical solution of the present invention to apply it to other occasions directly. The protection scope of the present invention shall be subject to the protection scope defined by the claims.

Claims

1. An astaxanthin oil liposome composition is characterized by comprising a component A, a component B and a component C;

the component B is a surfactant;

2. The astaxanthin oil liposome composition of claim 1, wherein the solvent for the astaxanthin oil is a drying oil comprising a conjugate acid;

the mass concentration of the astaxanthin oil is 0.1-12%.

3. The astaxanthin lipid liposome composition of claim 1, wherein the phospholipid compound is one or more selected from the group consisting of soybean lecithin, egg yolk lecithin, phosphatidylcholine, hydroxylated lecithin, hydrogenated soybean phospholipid, hydrogenated lecithin, cephalin, cardiolipin, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol, phosphatidic acid, phosphatidylethanolamine, dilauroyl phosphatidylcholine, dimyristoyl phosphatidylcholine, dipalmitoyl phosphatidylglycerol, dipalmitoyl phosphatidic acid, dipalmitoyl phosphatidylethanolamine, distearoyl phosphatidylcholine, dioleoyl phosphatidylcholine and dioleoyl phosphatidylethanolamine;

the non-hormonal sterol is one or more of ergosterol, beta-sitosterol, squalene and vitamin D/provitamin D;

the polyalcohol is one or more of propylene glycol, hexylene glycol, panthenol and butanediol.

4. The astaxanthin oil liposome composition according to claim 1, wherein the weight ratio of the astaxanthin oil, the phospholipid compound, the non-hormonal sterol steroid and the polyhydric alcohol in the component A is (1-42): (0.1-17): (0.005-3.33): (1-350).

5. The astaxanthin lipid liposome composition according to claim 1, wherein the fat-soluble antioxidant is one or more of guaiac resin, vitamin E, butylated hydroxyanisole, dibutyl hydroxytoluene, propyl gallate, tert-butyl hydroquinone, carotenoids and ubiquinone;

6. The astaxanthin lipidosome composition of claim 1, wherein the skin penetration agent is one or more of ethylhexyl isononanoate/lard, glycerin, carbomers, glyceryl polyethers, caprylic/capric triglyceride, isopropyl isostearate, n-butyl glycerol, polyethylene glycol and n-butanol.

7. The astaxanthin lipid composition of claim 1, wherein the efficacy-enhancing adjuvant comprises an antioxidant adjuvant, a skin care adjuvant, and a skin moisturizer;

8. The astaxanthin lipid liposome composition according to claim 1, wherein the skin nutrient is one or more selected from xanthan gum, hyaluronic acid, sodium hyaluronate, collagen peptide, elastin, palmitoyl tripeptide-1, palm pentapeptide-4, hydroxyproline, proline, leucine, isoleucine and glycine.

9. The astaxanthin oil liposome composition according to claim 1, wherein the mass ratio of the fat-soluble antioxidant, the water-soluble antioxidant, the skin penetrant, the functional component enhancement aid and the skin nutrient is (0.01-30): (1-700): (1-1500): (2-200): (1-50).

10. Use of an astaxanthin liposome composition according to any one of claims 1 to 9 in cosmetics.