CN110680780A - Thyme mouthwash oil and preparation method thereof - Google Patents
Thyme mouthwash oil and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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Abstract
The invention relates to the field of oral cleaning and nursing products, in particular to thyme mouthwash oil and a preparation method thereof, which solve the problems of strong oral irritation, oral mucosa injury and other side effects caused by common mouthwash on the market, and the thyme mouthwash oil comprises the following components in percentage by mass: 15-30% of polyoxyethylene hydrogenated castor oil, 5-20% of natural antibacterial peptide, 5-20% of thyme extract, 3-15% of xylitol, 1-8% of plant extract, 0.1-0.4% of menthol and the balance of alcohol solvent. The thyme mouthwash oil is transparent in appearance, and transparent ordinary mouthwash is obtained after the thyme mouthwash oil is diluted to 20-50 times with water, and the mouthwash is fresh and sweet in taste, and can clean oral cavities and refresh breath.
Description
Technical Field
The invention relates to the technical field of oral cleaning and nursing products, and particularly relates to thyme mouthwash oil and a preparation method thereof.
Background
The mouthwash is an oral care product for cleaning and health care in daily life of many people, particularly business people, but the mouthwash is often bottled in a large bottle and is inconvenient to carry about, and troubles are often brought to safety inspection and consignment of subways and airplanes. The mouthwash can be obtained by diluting the mouthwash oil by 30-50 times, 10ml of mouthwash oil can be used for gargling for 8-10 times, and the oral care needs can be met by carrying a small amount of mouthwash oil, so that the mouthwash is simple and convenient.
In addition, consumers are concerned about cleaning efficacy of mouthwash products and are concerned about whether mouthwash products can improve oral health problems, such as dental caries, oral ulcers, halitosis, and the like. Traditional mouthwash is generally prepared by using chemical reagents, and the common pharmaceutical ingredients of the mouthwash on the market comprise fluoride, triclosan, cetyl pyridinium chloride, chlorhexidine gluconate, potassium nitrate, sodium thiosulfate and the like, and the chemical drugs can kill part of harmful bacteria after contacting the surfaces of all parts of the oral cavity, but can also cause the side effects of strong irritation and harm to oral mucosa, for example, the fluoride can sterilize effectively, but also has harm to human bodies. Therefore, the mouthwash product which can clean the oral cavity and refresh the breath and is harmless to the oral cavity brings good news to consumers.
In patent CN108721176A, a mouthwash is disclosed, which provides a mouthwash formula using gallnut, perilla, cinnamon and rose essential oil as raw materials. The mouthwash takes traditional Chinese medicine substances as cleaning agents and bactericides, and can penetrate into subcutaneous parts of oral cavity, slits between teeth and gum to play a role in cleaning and bacteriostasis.
In patent CN108498401A, a mouthwash is disclosed, which is prepared by using weak alkali solution of sodium alginate as a carrier, and matching with lavender extract and Ɛ -polylysine, wherein the lavender extract has no stimulation to oral cavity, flavonoid and sterol compounds therein have good antibacterial effect, and the combination with Ɛ -polylysine has synergistic antibacterial effect, so that essential amino acids of human body are supplemented while continuous sterilization is realized. The product adopts amino acid for bacteriostasis, has novel idea, but has two defects: the product is instant mouthwash, so the product is inconvenient to carry; chemical substances such as sodium thiosulfate and sodium bicarbonate which have stimulating effects on the oral cavity are used.
Disclosure of Invention
In view of the above, there is a need to develop a gargle water product using plant-derived ingredients, which can effectively exert cleaning and bacteriostatic effects, has no irritation to oral cavity, and can be diluted for use to achieve the purpose of convenient carrying.
In order to achieve the purpose, the invention adopts the following technical scheme:
the thyme mouthwash oil comprises the following components in percentage by mass: 15-30% of polyoxyethylene hydrogenated castor oil, 5-20% of natural antibacterial peptide, 5-20% of thyme extract, 3-15% of xylitol, 1-8% of plant extract, 0.1-0.4% of menthol and the balance of alcohol solvent.
Further, the alcohol solvent is at least one of ethanol, polyethylene glycol 400 and propylene glycol.
Further, the preparation method of the thyme extract comprises the following steps:
s1, cleaning and drying thyme in the shade, cutting into pieces with the length of 1-5 cm, weighing 200-400 g, cleaning with deionized water, and placing in a volatile oil extractor;
s2, distilling for 5-7 h by using a steam distillation method, cooling, standing and layering, and taking the upper essential oil to obtain the thyme extract.
Furthermore, the mass ratio of the thyme extract to the plant extract is 1: 1-5: 1, preferably 3: 2-4: 1, and more preferably 2: 1-3: 1.
Furthermore, the polyoxyethylene hydrogenated castor oil is used as a solubilizer in a system, the thyme extract and the plant extract are solubilized in an alcohol solvent, and the mass ratio of the addition amount of the polyoxyethylene hydrogenated castor oil to the sum of the addition amounts of the thyme extract and the plant extract is 6: 1-0.5: 1, preferably 4: 1-1: 1, and more preferably 3: 1-3: 2.
Further, said xylitol and menthol are alcohol-based substances, and are miscible with thyme extract to provide a clear liquid, which solubilizes thyme extract and plant extract in an alcohol-based solvent.
Further, the plant extract comprises one or more of tea tree extract, eucalyptus globulus labill extract, honeysuckle extract, asarum extract and cassia twig extract.
Further, the preparation method of the tea tree extract, the eucalyptus globulus labill extract and the honeysuckle extract comprises the following steps:
s1, preparing tea tree tender shoots, eucalyptus globulus leaf and fresh honeysuckle, respectively cleaning the tea tree tender shoots, the eucalyptus globulus leaf and the fresh honeysuckle with deionized water, drying the eucalyptus globulus leaf in the shade, cutting the dried eucalyptus globulus leaf into rectangular fragments with the side length of 1-3 cm, respectively weighing 200-400 g of the fragments, and respectively placing the fragments in a volatile oil extractor;
s2, distilling for 5-7 h by using a steam distillation method, cooling, standing for layering, and respectively taking upper essential oil to obtain the tea tree extract, the eucalyptus globulus labill extract and the honeysuckle extract.
Further, the preparation method of the asarum extract comprises the following steps:
s1, weighing 40-60 g of asarum, cleaning, drying, and crushing by using a crusher to obtain asarum powder;
s2, adding asarum powder into an ethanol solution with the volume of 350-450 mL and the concentration of 80-100%, sealing with a preservative film, and soaking for 46-50 h to obtain a crude extract of asarum;
s3, filtering the crude extract of asarum to obtain a filtrate, evaporating the ethanol solution of the filtrate by using a rotary evaporator, wherein the vacuum degree of the rotary evaporator is 0.08-0.1MPa, and evaporating to the volume of 8-12 mL to obtain the asarum extract of 8-12 mL.
Further, the preparation method of the cassia twig extract comprises the following steps:
s1, weighing 40-60 g of cassia twig, cleaning, drying, and crushing by using a crusher to obtain cassia twig powder;
s2, adding the cassia twig powder into 400-500 mL deionized water, sealing with a preservative film, and soaking for 22-26 h to obtain a crude extract of the cassia twig;
s3, filtering the crude extraction liquid to obtain a filtrate, putting the filtrate into a volatile oil extractor, distilling for 5-7 h by using a steam distillation method, cooling, standing for layering, and putting an upper oil layer, namely the crude extract of cassia twig, into a separating funnel;
s4, extracting the crude extract of the cassia twig by using petroleum ether, taking a petroleum ether layer, evaporating the petroleum ether layer by using a rotary evaporator, and recovering the petroleum ether, wherein the vacuum degree of the rotary evaporator is 0.08-0.1MPa, and evaporating to the volume of 8-12 mL to obtain 8-12 mL of the extract of the cassia twig.
The invention also provides a preparation method of the thyme mouthwash oil, which comprises the following steps:
s1, mixing the polyoxyethylene hydrogenated castor oil, the thyme extract, the plant extract, the xylitol and the menthol, heating to 40-50 ℃, dissolving into a transparent solution, and cooling to normal temperature to obtain a traditional Chinese medicine mixed solution;
s2, adding the alcohol solvents into a clean stirring container, and slowly adding the traditional Chinese medicine mixed solution into the container while stirring to obtain primary thyme mouthwash oil;
s3, slowly adding the natural antibacterial peptide into the primary thyme mouthwash oil while stirring the primary thyme mouthwash oil to obtain the thyme mouthwash oil.
Compared with the prior art, the invention has the beneficial effects that:
the thyme mouthwash oil is prepared from natural components extracted from plants as main raw materials, and is healthy and free of side effects. These plant extracts include thyme extract, tea plant extract, eucalyptus globulus labill extract, honeysuckle extract, asarum extract, cassia twig extract, xylitol and menthol. The respective effects of the plant extracts are as follows:
thyme extract: the thyme extract has strong herb fragrance, sweet and mild herb fragrance with pungent fragrance, and slight wine taste. The main components of the compound are thymol (40-70%) and carvacrol (2-15%), and the thymol and the carvacrol are isomers. It is mainly used for food spices such as sausage, canned meat, sauce, etc., antitussive, and daily essence such as detergent and soap. Thymol has stronger bactericidal effect than phenol, has low toxicity, has bactericidal and fungicidal effects on oral cavity and throat mucosa, has antiseptic and local anesthesia effects on dental caries cavity, and can be used for sterilizing oral cavity and throat, dermatophytosis, actinomycosis and otitis. Can promote movement of trachea cilia, is beneficial to secretion of trachea mucus, has effect of eliminating phlegm, and also has antibacterial effect, so can be used for treating tracheitis, pertussis, etc.
Eucalyptus globulus labill extract: the Eucalyptus globulus Labill extract can be obtained by distilling dried leaves by steam distillation, and has oil yield of about 3%. The chemical components of the medicine are eucalyptol (about 90 percent), pinene, camphene, phellandrene and the like, and the substances have various biological activities of antibiosis, anti-inflammation, antioxidation, blood sugar reduction and the like, and have the effects of dispelling wind, relieving heat, inhibiting bacteria, diminishing inflammation, preventing corrosion, relieving itching and the like. The Eucalyptus globulus Labill extract has slight camphor smell, and is fresh and non-irritating. In personal care products such as chewing gum, toothpaste, gargle, etc., the Eucalyptus globulus Labill extract mainly has the functions of sterilization and perfuming.
Tea tree extract: the tea tree extract belongs to natural oil and fat, has aromatic terpenoid smell and slightly bitter taste. The tea tree extract is a natural bactericide, is commonly used for treating external abrasion, mosquito bite and bacterial infection of a human body, and has the functions of diminishing inflammation and inhibiting bacteria; also commonly used in personal care products as anti-inflammatory, antibacterial agents; in oral care, tea extract can relieve gingival bleeding and gingival swelling and pain, in addition to anti-inflammatory and antibacterial effects. The high-purity tea tree extract can be obtained by steam distillation, and is high in safety and is in the purchase list of the United states food and drug administration.
The asarum extract: the asarum extract contains various nutrient elements, amino acids and the like, and the beverage prepared by taking the asarum extract as the raw material has pure taste and faint scent, has certain functions of reducing blood pressure and blood fat, is widely used for daily products such as soap, cosmetics, toothpaste and the like, and has the curative effects of resisting bacteria, resisting inflammation, stopping bleeding, relieving pain and the like.
Xylitol: xylitol, known by the chemical name pentol, is a natural sweetener extracted from plant materials such as white birch, corncob, sugarcane, etc. Xylitol has a cool sweet taste, but does not have the high calorie of sugar (the calorific value is 16.72 kJ/g), and is the most widely used sugar substitute. Xylitol metabolism is not regulated by insulin, is completely metabolized in a human body, and is a healthy sweet source for diabetics.
Menthol: menthol is a white crystal and is extracted from the leaves and stems of peppermint, which is the main component of common peppermint essential oils. Menthol is a saturated cyclic alcohol, and the substance can refresh breath and also has the effects of antisepsis, sterilization and the like; meanwhile, it is very soluble in alcohol solvent due to the hydroxyl group, and can solubilize thyme extract, tea extract and asarum extract.
1. The thyme mouthwash oil is used by diluting 30-50 times with water as mouthwash, and a small amount of mouthwash oil can be used for multiple times, so that the thyme mouthwash oil is particularly convenient for business people to carry about. The gargle oil can be quickly mixed with water to form a transparent aqueous liquid, and when used for gargling, the gargle oil is cool and sweet in taste, and has the effects of cleaning oral cavity, refreshing breath and having no stimulation to the oral cavity.
2. The thyme extract, the plant extract, the xylitol and the menthol in the thyme mouthwash oil have good solubility in alcohol solvents such as ethanol and propylene glycol, and are matched with the solubilization of polyoxyethylene hydrogenated castor oil, the xylitol and the menthol, so that the whole system is uniform, transparent and stable in performance, and cannot generate the phenomena of turbidity and layering.
3. The thyme mouthwash oil has the advantages of readily available raw materials, simple preparation process and low cost.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Example one
The thyme mouthwash oil comprises the following components in percentage by mass: 20% of natural antibacterial peptide, 25% of polyoxyethylene hydrogenated castor oil, 12% of thyme extract, 1.5% of tea tree extract, 1% of eucalyptus globulus extract, 8% of xylitol, 0.2% of menthol and 32.3% of ethanol;
the preparation method comprises the following steps:
s1, mixing the polyoxyethylene hydrogenated castor oil, the thyme extract, the tea tree extract, the eucalyptus globulus extract, the xylitol and the menthol according to the formula amount, heating to 45 ℃ to dissolve the mixture into a transparent solution, and cooling to normal temperature to obtain a traditional Chinese medicine mixed solution;
s2, slowly adding the traditional Chinese medicine mixed solution into the ethanol with the formula amount while stirring to obtain primary mouthwash oil;
s3, slowly adding the natural antibacterial peptide with the formula amount into the primary mouthwash oil while stirring the primary mouthwash oil to obtain the thyme mouthwash oil.
Example two
The thyme mouthwash oil comprises the following components in percentage by mass: 20% of natural antibacterial peptide, 25% of polyoxyethylene hydrogenated castor oil, 12% of thyme extract, 1.5% of tea tree extract, 1% of eucalyptus globulus extract, 8% of xylitol, 0.2% of menthol, 22.3% of ethanol and 40010% of polyethylene glycol;
the preparation method comprises the following steps:
s1, mixing the polyoxyethylene hydrogenated castor oil, the thyme extract, the tea tree extract, the eucalyptus globulus extract, the xylitol and the menthol according to the formula amount, heating to 45 ℃ to dissolve the mixture into a transparent solution, and cooling to normal temperature to obtain a traditional Chinese medicine mixed solution;
s2, stirring the ethanol and the polyethylene glycol 400 according to the formula amount, and slowly adding the traditional Chinese medicine mixed solution into the mixture to obtain primary mouthwash oil;
s3, slowly adding the natural antibacterial peptide with the formula amount into the primary mouthwash oil while stirring the primary mouthwash oil to obtain the thyme mouthwash oil.
The data show that the alcoholic solvent in the formulation of example two was changed from 32.3% ethanol to 22.3% ethanol and 10% polyethylene glycol 400 compared to example one. This has no effect on the transparency, consistency of the overall system. If too much ethanol is feared to irritate the oral cavity, a portion of the ethanol may be replaced with polyethylene glycol 400, which is not irritating.
EXAMPLE III
The thyme mouthwash oil comprises the following components in percentage by mass: 5% of natural antibacterial peptide, 30% of polyoxyethylene hydrogenated castor oil, 20% of thyme extract, 1% of tea tree extract, 0.5% of eucalyptus globulus extract, 8% of xylitol, 0.2% of menthol and 35.3% of ethanol.
The preparation method comprises the following steps:
s1, mixing the polyoxyethylene hydrogenated castor oil, the thyme extract, the tea tree extract, the eucalyptus globulus extract, the xylitol and the menthol according to the formula amount, heating to 45 ℃ to dissolve the mixture into a transparent solution, and cooling to normal temperature to obtain a traditional Chinese medicine mixed solution;
s2, slowly adding the traditional Chinese medicine mixed solution into the ethanol with the formula amount while stirring to obtain primary mouthwash oil;
s3, slowly adding the natural antibacterial peptide with the formula amount into the primary mouthwash oil while stirring the primary mouthwash oil to obtain the thyme mouthwash oil.
The data show that compared with the first and second examples, the content of the thyme extract in the formula of the third example is increased to 20%, and other substances are adjusted correspondingly to ensure that the traditional Chinese medicine mixed solution can be dissolved in ethanol, so that the thyme mouthwash oil containing the thyme extract with high transparency is obtained.
And (3) safety testing: the mouthwash oils of the first to third examples were diluted 30 times with water, respectively, to obtain 1 to 3 mouthwashes. 24 mice are selected and divided into 4 groups at random, each group is separately irrigated with 1-3 parts of mouthwash and tap water, the amount of the irrigated stomach is 0.2g/10g, the gavage is performed once a day, and the tracking observation is carried out for three months. After three months, all mice normally move without any adverse reaction, which indicates that the reagent is a non-toxic or low-toxic reagent.
And (3) antibacterial property test: 40 subjects were randomly divided into A, B, C and D groups, A, B and C groups were tested for oral bacterial clearance after being diluted 40 times with water using the mouthwash prepared in examples one, two and three, respectively, and group D was rinsed with tap water as a control group. The testers used the designated mouthwash every day after breakfast, lunch and dinner, and the mouthwash was swished for 3 minutes after drinking for three days. Oral liquid before and after gargling is taken after each meal to check the oral bacteria clearance rate, the bacteria clearance rate of each experimental group is calculated by adopting an average value, and the calculation method of the clearance rate is as follows: (number of bacteria before gargling-number of bacteria after gargling)/100% before gargling. A. B, C and group D experimenters had 83%, 82%, 87% and 17% oral bacteria clearance, respectively. The thyme mouth wash has good antibacterial effect in oral care, and the content of the thyme extract is slightly increased to help the antibacterial.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (10)
1. The thyme mouthwash oil is characterized by comprising the following components in percentage by mass: 15-30% of polyoxyethylene hydrogenated castor oil, 5-20% of natural antibacterial peptide, 5-20% of thyme extract, 3-15% of xylitol, 1-8% of plant extract, 0.1-0.4% of menthol and the balance of alcohol solvent.
2. The thyme mouthwash according to claim 1, wherein the alcoholic solvent is at least one of ethanol, polyethylene glycol 400, and propylene glycol.
3. The thyme mouthwash oil of claim 1, wherein the thyme extract is prepared by a method comprising the steps of:
s1, cleaning and drying thyme in the shade, cutting into pieces with the length of 1-5 cm, weighing 200-400 g, cleaning with deionized water, and placing in a volatile oil extractor;
s2, distilling for 5-7 h by using a steam distillation method, cooling, standing and layering, and taking the upper essential oil to obtain the thyme extract.
4. The thyme mouthwash oil according to claim 1, wherein the mass ratio of the thyme extract to the plant extract is 1:1 to 5:1, preferably 3:2 to 4:1, and more preferably 2:1 to 3: 1.
5. The thyme mouthwash oil according to claim 1, wherein the polyoxyethylene hydrogenated castor oil is used as a solubilizer in a system, the thyme extract and the plant extract are solubilized in an alcohol solvent, and the mass ratio of the addition amount of the polyoxyethylene hydrogenated castor oil to the sum of the addition amounts of the thyme extract and the plant extract is 6: 1-0.5: 1, preferably 4: 1-1: 1, and more preferably 3: 1-3: 2.
6. The thyme mouthwash oil of claim 1, wherein the plant extract comprises one or more of a tea tree extract, a eucalyptus globulus labill extract, a honeysuckle extract, an asarum extract, and a cassia twig extract.
7. The thyme mouthwash oil as claimed in claim 6, wherein the preparation method of the tea tree extract, the eucalyptus globulus labill extract and the honeysuckle flower extract comprises the following steps:
s1, preparing tea tree tender shoots, eucalyptus globulus leaf and fresh honeysuckle, respectively cleaning the tea tree tender shoots, the eucalyptus globulus leaf and the fresh honeysuckle with deionized water, drying the eucalyptus globulus leaf in the shade, cutting the dried eucalyptus globulus leaf into rectangular fragments with the side length of 1-3 cm, respectively weighing 200-400 g of the fragments, and respectively placing the fragments in a volatile oil extractor;
s2, distilling for 5-7 h by using a steam distillation method, cooling, standing for layering, and respectively taking upper essential oil to obtain the tea tree extract, the eucalyptus globulus labill extract and the honeysuckle extract.
8. The thyme mouthwash oil of claim 6, wherein the asarum extract is prepared by a method comprising the steps of:
s1, weighing 40-60 g of asarum, cleaning, drying, and crushing by using a crusher to obtain asarum powder;
s2, adding asarum powder into an ethanol solution with the volume of 350-450 mL and the concentration of 80-100%, sealing with a preservative film, and soaking for 46-50 h to obtain a crude extract of asarum;
s3, filtering the crude extract of asarum to obtain a filtrate, evaporating the ethanol solution of the filtrate by using a rotary evaporator, wherein the vacuum degree of the rotary evaporator is 0.08-0.1MPa, and evaporating to the volume of 8-12 mL to obtain the asarum extract of 8-12 mL.
9. The thyme mouthwash oil of claim 6, wherein the cassia twig extract is prepared by a method comprising the steps of:
s1, weighing 40-60 g of cassia twig, cleaning, drying, and crushing by using a crusher to obtain cassia twig powder;
s2, adding the cassia twig powder into 400-500 mL deionized water, sealing with a preservative film, and soaking for 22-26 h to obtain a crude extract of the cassia twig;
s3, filtering the crude extraction liquid to obtain a filtrate, putting the filtrate into a volatile oil extractor, distilling for 5-7 h by using a steam distillation method, cooling, standing for layering, and putting an upper oil layer, namely the crude extract of cassia twig, into a separating funnel;
s4, extracting the crude extract of the cassia twig by using petroleum ether, taking a petroleum ether layer, evaporating the petroleum ether layer by using a rotary evaporator, and recovering the petroleum ether, wherein the vacuum degree of the rotary evaporator is 0.08-0.1MPa, and evaporating to the volume of 8-12 mL to obtain 8-12 mL of the extract of the cassia twig.
10. A method of preparing thyme mouthwash oil according to any one of claims 1 to 8, comprising the steps of:
s1, mixing the polyoxyethylene hydrogenated castor oil, the thyme extract, the plant extract, the xylitol and the menthol, heating to 40-50 ℃, dissolving into a transparent solution, and cooling to normal temperature to obtain a traditional Chinese medicine mixed solution;
s2, adding the alcohol solvents into a clean stirring container, and slowly adding the traditional Chinese medicine mixed solution into the container while stirring to obtain primary thyme mouthwash oil;
s3, slowly adding the natural antibacterial peptide into the primary thyme mouthwash oil while stirring the primary thyme mouthwash oil to obtain the thyme mouthwash oil.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113456518A (en) * | 2021-07-16 | 2021-10-01 | 北京洗得宝消毒制品有限公司 | Composite polypeptide mouthwash and preparation method thereof |
| CN114432201A (en) * | 2022-02-21 | 2022-05-06 | 清远中大创新药物研究中心 | Cassia twig mouthwash raw material composition and application thereof |
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| CN103893026A (en) * | 2014-03-31 | 2014-07-02 | 陈光健 | Mouth wash for oral hygiene and health care |
| CN104288047A (en) * | 2014-10-10 | 2015-01-21 | 高莉萍 | Green tea mouth wash |
| CN108815232A (en) * | 2018-07-06 | 2018-11-16 | 李同宾 | A kind of draft antimicrobial fluid |
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2019
- 2019-08-21 CN CN201910772632.2A patent/CN110680780A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893026A (en) * | 2014-03-31 | 2014-07-02 | 陈光健 | Mouth wash for oral hygiene and health care |
| CN104288047A (en) * | 2014-10-10 | 2015-01-21 | 高莉萍 | Green tea mouth wash |
| CN108815232A (en) * | 2018-07-06 | 2018-11-16 | 李同宾 | A kind of draft antimicrobial fluid |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113456518A (en) * | 2021-07-16 | 2021-10-01 | 北京洗得宝消毒制品有限公司 | Composite polypeptide mouthwash and preparation method thereof |
| CN114432201A (en) * | 2022-02-21 | 2022-05-06 | 清远中大创新药物研究中心 | Cassia twig mouthwash raw material composition and application thereof |
| CN114432201B (en) * | 2022-02-21 | 2023-08-15 | 罗定市亿绿实业投资有限公司 | Ramulus Cinnamomi mouthwash raw material composition and application thereof |
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