CN110638921A - 一种具有补肾功能的口服液及其制备方法 - Google Patents
一种具有补肾功能的口服液及其制备方法 Download PDFInfo
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Abstract
本发明涉及保健食品技术领域,具体涉及一种具有补肾功能的口服液及其制备方法。该口服液包括重量份的如下原料:山药15~45份、枸杞子8~30份、木耳5~20份、莲子5~18份、葡萄4~12份、桑葚4~12份、黑豆2~5份、黑芝麻2~5份、桔子粉2~5份、9000~12000mL纯化水。制备方法为原料处理、处理液混合、灌装、灭菌及产品检验。本发明具有补肾功能的口服液中主要原料为常用的优质食材及中药:山药、枸杞子、木耳、莲子、葡萄、桑葚、黑豆及黑芝麻起到了全面改善睡眠质量功能的作用。考虑口感的问题,在产品中加入桔子粉调节口味,是口感更佳。本发明具有补肾功能的口服液的制备方法简单,操作方便;节省成本和劳动力;工艺设备安全卫生。
Description
技术领域
本发明涉及保健食品技术领域,具体涉及一种具有补肾功能的口服液及其制备方法。
背景技术
肾为先天之本,肾中***,是一身阴液的总源。***亏损会引发各种疾病,如头晕耳鸣,腰膝酸软,骨蒸潮热,糖尿病及脱发等。
中医认为,肾虚分肾阴虚和肾阳虚,要根据不同的症状做不同的诊治。阳虚症状:腰膝酸痛,或腰背冷痛,畏寒肢冷,尤以下肢为甚;头目眩晕,精神萎靡,面色白或黎黑;舌淡胖苔白,脉沉弱;男性易阳痿早泄,妇女易宫寒***;或大便久泄不止,完谷不化,五更泄泻;或浮肿,腰以下为甚,按之凹陷不起,甚则腹部胀痛,心悸咳喘。阴虚症状:腰膝酸软、两腿无力,眩晕耳鸣,脱发齿松,盗汗失眠,梦呓磨牙,口干,尿黄,大便干燥,男子阳强易举或阳痿、早泄、遗精,妇女经少经闭,或见崩漏,形体消瘦,潮热盗汗,五心烦热,咽干颧红,溲黄便干,舌红少津,脉细数。
目前,伴随着社会的进步和人们生活水平的提高,越来越多的人开始关注日常保健。市场上补肾的产品大多为药物或是保健品,形势也较为单一且对身体健康有损坏,药物药效差、副作用较多,会对人体健康造成伤害。因此,以补肾为主要功能的保健品市场潜力巨大。
发明内容
基于上述问题,本发明目的提供一种具有补肾功能的口服液及其制备方法。
一种具有补肾功能的口服液,该口服液包括重量份的如下原料:山药15~45份、枸杞子8~30份、木耳5~20份、莲子5~18份、葡萄4~12份、桑葚4~12份、黑豆2~5份、黑芝麻 2~5份、桔子粉2~5份、9000~12000mL纯化水。
优化的,该口服液包括重量份的如下原料:山药30份、枸杞子8份、木耳20份、莲子12份、葡萄11份、桑葚11份、黑豆3份、黑芝麻2份、桔子粉3份、10000mL纯化水。
上述一种具有补肾功能的口服液的制备方法:具体包括如下步骤:
步骤一:将山药、枸杞子、木耳及葡萄用水淋清洗干净,置于夹层锅中,十倍水量煎煮1.5小时,趁热过200目筛,滤液放置于配制罐中备用;
步骤二:将莲子和桑葚洗净后加入3倍量纯化水煎煮1.5小时,趁热过200目筛,滤液备用;
步骤三:将黑豆和黑芝麻阴干后用粉碎机粉碎后,过100目筛备用,置于配置罐中,加热煮沸40分钟,搅拌使溶解,趁热过200目筛,滤液备用;
步骤四:将上述三个步骤的滤液与桔子粉按比例混合均匀,纯化水定容至足量;
步骤五:将步骤四的混合液冷藏静置48小时后,通过板框过滤机过滤得到滤液;
步骤六:将步骤五的滤液放置于洁净不锈钢贮液罐内,用灌装机灌装于符合卫生要求的棕色玻璃瓶中,调整装量规格为10mL/支;
步骤七:罐装过后在115℃条件下灭菌25分钟,然后包装后进行成品检验。
进一步的,所述步骤二至六均在十万级洁净空间进行。
相比于现有的技术,本发明具有如下有益效果:
本发明具有补肾功能的口服液中主要原料为常用的优质食材及中药:山药、枸杞子、木耳、莲子、葡萄、桑葚、黑豆及黑芝麻起到了全面改善睡眠质量功能的作用。考虑口感的问题,在产品中加入桔子粉调节口味,是口感更佳。本发明具有补肾功能的口服液的制备方法简单,操作方便;节省成本和劳动力;工艺设备安全卫生。
具体实施方式
下面将结合实施例对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
一种具有补肾功能的口服液,该口服液包括重量份的如下原料:山药450g、枸杞子300g、木耳50g、莲子50g、葡萄40g、桑葚40g、黑豆20g、黑芝麻30g、桔子粉20g、9000mL纯化水。
上述一种具有补肾功能的口服液的制备方法:具体包括如下步骤:
步骤一:将山药、枸杞子、木耳及葡萄用水淋清洗干净,置于夹层锅中,十倍水量煎煮1.5小时,趁热过200目筛,滤液放置于配制罐中备用;
步骤二:将莲子和桑葚洗净后加入3倍量纯化水煎煮1.5小时,趁热过200目筛,滤液备用;
步骤三:将黑豆和黑芝麻阴干后用粉碎机粉碎后,过100目筛备用,置于配置罐中,加热煮沸40分钟,搅拌使溶解,趁热过200目筛,滤液备用;
步骤四:将上述三个步骤的滤液与桔子粉按比例混合均匀,纯化水定容至足量;
步骤五:将步骤四的混合液冷藏静置48小时后,通过板框过滤机过滤得到滤液;
步骤六:将步骤五的滤液放置于洁净不锈钢贮液罐内,用灌装机灌装于符合卫生要求的棕色玻璃瓶中,调整装量规格为10mL/支;
步骤七:罐装过后在115℃条件下灭菌25分钟,然后包装后进行成品检验。其中,上述步骤二至六均在十万级洁净空间进行。
实施例2
一种具有补肾功能的口服液,该口服液包括重量份的如下原料:山药300g、枸杞子80g、木耳200g、莲子120g、葡萄110g、桑葚110g、黑豆30g、黑芝麻20g、桔子粉30g、10000mL纯化水。
上述一种具有补肾功能的口服液的制备方法:具体包括如下步骤:
步骤一:将山药、枸杞子、木耳及葡萄用水淋清洗干净,置于夹层锅中,十倍水量煎煮1.5小时,趁热过200目筛,滤液放置于配制罐中备用;
步骤二:将莲子和桑葚洗净后加入3倍量纯化水煎煮1.5小时,趁热过200目筛,滤液备用;
步骤三:将黑豆和黑芝麻阴干后用粉碎机粉碎后,过100目筛备用,置于配置罐中,加热煮沸40分钟,搅拌使溶解,趁热过200目筛,滤液备用;
步骤四:将上述三个步骤的滤液与桔子粉按比例混合均匀,纯化水定容至足量;
步骤五:将步骤四的混合液冷藏静置48小时后,通过板框过滤机过滤得到滤液;
步骤六:将步骤五的滤液放置于洁净不锈钢贮液罐内,用灌装机灌装于符合卫生要求的棕色玻璃瓶中,调整装量规格为10mL/支;
步骤七:罐装过后在115℃条件下灭菌25分钟,然后包装后进行成品检验。其中,上述步骤二至六均在十万级洁净空间进行。
实施例3
一种具有补肾功能的口服液,该口服液包括重量份的如下原料:山药150g、枸杞子130g、木耳150g、莲子180g、葡萄120g、桑葚120g、黑豆50g、黑芝麻50g、桔子粉50g、12000mL纯化水。
上述一种具有补肾功能的口服液的制备方法:具体包括如下步骤:
步骤一:将山药、枸杞子、木耳及葡萄用水淋清洗干净,置于夹层锅中,十倍水量煎煮1.5小时,趁热过200目筛,滤液放置于配制罐中备用;
步骤二:将莲子和桑葚洗净后加入3倍量纯化水煎煮1.5小时,趁热过200目筛,滤液备用;
步骤三:将黑豆和黑芝麻阴干后用粉碎机粉碎后,过100目筛备用,置于配置罐中,加热煮沸40分钟,搅拌使溶解,趁热过200目筛,滤液备用;
步骤四:将上述三个步骤的滤液与桔子粉按比例混合均匀,纯化水定容至足量;
步骤五:将步骤四的混合液冷藏静置48小时后,通过板框过滤机过滤得到滤液;
步骤六:将步骤五的滤液放置于洁净不锈钢贮液罐内,用灌装机灌装于符合卫生要求的棕色玻璃瓶中,调整装量规格为10mL/支;
步骤七:罐装过后在115℃条件下灭菌25分钟,然后包装后进行成品检验。其中,上述步骤二至六均在十万级洁净空间进行。
实施例4
毒理实验:
1、试验目的:本发明具有补肾功能的口服液是否有毒。
实验材料:(1)样品:具有补肾功能的口服液,人体口服液推荐量为每日20mL,成人体重按60kg计算,折合剂量0.333mL/kg/天,取5倍浓缩液进行实验。
2、实验动物:清洁级昆明种小鼠、SD大鼠及饲料。
3、实验环境条件:温度22~24℃,湿度52~58%。
4、实验方法:
通过小鼠急性毒理实验(取具有补肾功能的口服液5倍浓缩液给小鼠按0.2mL/10g.bw的灌胃体积给小鼠一次性经口灌胃)、Ames试验(试验设五个剂量,分别为5000μg/皿、1000μg/皿、200μg/皿、40μg/皿、8μg/皿,同时设自发回变、溶剂对照和阳性突变剂对照)、小鼠骨髓嗜多染红细胞核试验(以40mg/kg.bw剂量的环磷酰胺为阳性对照,蒸馏水为阴性对照,试验组3个剂量分别为10.0mL/kg.bw、5.0mL/kg.bw、2.5mL/kg.bw,取具有补肾功能的口服液5倍浓缩液50.0mL、25mL、12.5mL加蒸馏水至100mL,配成相应剂量的受试液给小鼠灌胃)、小鼠***畸形试验(以40mg/kg.bw剂量的环磷酰胺为阳性对照,蒸馏水为阴性对照,试验组3个剂量分别为10.0mL/kg.bw、5.0mL/kg.bw、2.5mL/kg.bw取具有补肾功能的口服液5倍浓缩液50.0mL、25.0mL、12.5mL加蒸馏水至50mL,配成相应剂量的受试液给小鼠灌胃)、30天喂养试验(取具有补肾功能的口服液5倍浓缩液17mL、33mL、67mL,加蒸馏水定容至100mL,对照组给与等体积蒸馏水,每日灌胃一次,连续30天)来进行毒理学试验评定。
5、试验结果:
(1)急性经口毒性试验:对雌、雄昆明种小鼠的最大耐受剂量大于20.0mL/kg.bw,属于无毒级。
(2)遗传毒性试验:Ames试验、小鼠骨髓嗜多染红细胞微核试验及小鼠***畸形试验结果均为阴性。
(3)30天喂养试验:以1.7mL/kg.bw、3.3mL/kg.bw、6.7mL/kg.bw剂量的具有补肾功能的口服液5倍浓缩液给大鼠灌胃30天,实验期间,动物生长发育好,各剂量组体重、增重、食物利用率、血常规指标、脏器重量及脏器/体重比值与对照组比较,无显著性差异。大体解剖和组织病理检查未见与样品有关的异常改变。在本实验条件下,在1.7mL/kg.bw~6.7mL/kg.bw剂量范围内,未见具有补肾功能的口服液30天喂养大鼠有明显毒副作用。
尽管已经示出和描述了本发明的实施例,对于本领域的普通技术人员而言,可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型,本发明的范围由所附权利要求及其等同物限定。
Claims (4)
1.一种具有补肾功能的口服液,其特征在于,该口服液包括重量份的如下原料:山药15~45份、枸杞子8~30份、木耳5~20份、莲子5~18份、葡萄4~12份、桑葚4~12份、黑豆2~5份、黑芝麻 2~5份、桔子粉2~5份、9000~12000mL纯化水。
2.根据权利要求1所述的一种具有补肾功能的口服液,其特征在于,优化的,该口服液包括重量份的如下原料:山药30份、枸杞子8份、木耳20份、莲子12份、葡萄11份、桑葚11份、黑豆3份、黑芝麻2份、桔子粉3份、10000mL纯化水。
3.权利要求1所述一种具有补肾功能的口服液的制备方法,其特征在于,具体包括如下步骤:
步骤一:将山药、枸杞子、木耳及葡萄用水淋清洗干净,置于夹层锅中,十倍水量煎煮1.5小时,趁热过200目筛,滤液放置于配制罐中备用;
步骤二:将莲子和桑葚洗净后加入3倍量纯化水煎煮1.5小时,趁热过200目筛,滤液备用;
步骤三:将黑豆和黑芝麻阴干后用粉碎机粉碎后,过100目筛备用,置于配置罐中,加热煮沸40分钟,搅拌使溶解,趁热过200目筛,滤液备用;
步骤四:将上述三个步骤的滤液与桔子粉按比例混合均匀,纯化水定容至足量;
步骤五:将步骤四的混合液冷藏静置48小时后,通过板框过滤机过滤得到滤液;
步骤六:将步骤五的滤液放置于洁净不锈钢贮液罐内,用灌装机灌装于符合卫生要求的棕色玻璃瓶中,调整装量规格为10mL/支;
步骤七:罐装过后在115℃条件下灭菌25分钟,然后包装后进行成品检验。
4.根据权利要求3所述的一种具有补肾功能的口服液的制备方法,其特征在于,所述步骤二至六均在十万级洁净空间进行。
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