CN110547472A - 一种含肽类特殊医学用途配方食品及其制备方法 - Google Patents
一种含肽类特殊医学用途配方食品及其制备方法 Download PDFInfo
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- CN110547472A CN110547472A CN201810544574.3A CN201810544574A CN110547472A CN 110547472 A CN110547472 A CN 110547472A CN 201810544574 A CN201810544574 A CN 201810544574A CN 110547472 A CN110547472 A CN 110547472A
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- vitamin
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Classifications
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- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
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- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
本发明提供一种全营养含肽特殊医学用途配方食品，每100g所述全营养含肽特殊医学用途配方食品中含有：低聚肽10‑20g，水解乳清蛋白5‑11g，抗性糊精20‑40g，麦芽糊精20‑40g，结晶果糖1‑5g，木糖醇3‑8g，柠檬酸钠0.1‑1g，环糊精0.1‑1g，植物油脂1‑10g，虫草多糖0.005‑0.1g，矿物质预混料3‑7g，维生素预混料0.2‑1g，左旋肉碱0.1‑1g，牛磺酸0.05‑0.2g，氯化钠0.05‑0.2g。适用于消化道功能轻、中度受损者，适用于外伤、感染或手术前后的患者，适用于肠道诊断检察及术前肠道准备的患者和肿瘤、烧伤等营养需求量增加的患者以及慢性疾病或老年人需口服营养补充的患者等。能有效帮助患者提高免疫力，能够解决病患厌食、体重下降、活动受限、免疫力低下等症状问题。
Description
技术领域
本发明涉及一种营养制剂，尤其涉及一种全营养含肽特殊医学用途配方食品及其制备方法。
背景技术
临床病人的营养支持尤其重要，自20世纪60年代以来，临床营养支持的相关研究进展迅速，营养支持与抗生素的应用、临床输血技术、重症监护与支持、麻醉技术、免疫调控及体外循环技术等一并被认为是上世纪医学研究最伟大的成果。现代临床营养包括肠外营养（PN）与肠内营养（EN），但随着两种营养支持方式的广泛应用和深入研究，肠内营养的优势逐渐显现出来。危重症病人营养不良发生率高达50％，可导致骨骼肌体积与力量、胃肠道功能完整性、免疫功能和抗应激反应能力不同程度下降；手术前后胃肠道蠕动功能不强，吸收、消化功能仍较弱；充分利用患者手术前后的部分消化功能，促进患者消化功能的全面恢复，提升免疫功能，增强机体抗病能力，从而促进身体的康复。
发明内容
本发明提供一种全营养含肽特殊医学用途配方食品，适用于消化道功能轻、中度受损者，适用于外伤、感染或手术前后的患者，适用于肠道诊断检察及术前肠道准备的患者和肿瘤、烧伤等营养需求量增加的患者以及慢性疾病或老年人等需口服营养补充的患者。能有效帮助患者提高免疫力，解决病患厌食、体重下降、活动受限、免疫力低下等症状问题。
本发明提供一种全营养含肽特殊医学用途配方食品，每100g所述全营养含肽特殊医学用途配方食品中含有：
低聚肽10-20g，
水解乳清蛋白5-11g，
抗性糊精20-40g，
麦芽糊精20-40g，
结晶果糖1-5g，
木糖醇3-8g，
柠檬酸钠0.1-1g，
环糊精0.1-1g，
植物油脂1-10g，
虫草多糖0.005-0.1g，
矿物质预混料 3-7g，
维生素预混料 0.2-1g，
左旋肉碱0.1-1g，
牛磺酸0.05-0.2g，
氯化钠0.05-0.2g。
其中，所述低聚肽为海洋鱼低聚肽或大豆低聚肽；所述植物油脂为植物油或植物油粉末；所述植物油为椰子油、棕榈油、大豆油、葵花籽油、亚麻籽油，含肽特殊医学用途配方食品制备方法为将所有原料加到水中、剪切、均质、灭菌、喷雾干燥制成粉末。
其中，所述植物油粉末由植物油和麦芽糊精组成，二者的重量比为(40-60)：(40-60)，将植物油和麦芽糊精混合、溶于水、搅拌、喷雾干燥制成粉末即得到所述植物油粉末，植物油为椰子油、棕榈油、大豆油、葵花籽油、亚麻籽油，含肽特殊医学用途配方食品制备方法为将所有原料加到一起，混合。
其中，复合维生素预混料由维生素A、维生素D、维生素E、维生素B1、维生素B2、维生素B6、维生素B12、维生素C、烟酰胺、泛酸、叶酸、生物素组成，1g复合维生素预混料含维生素A400-1000 ug、维生素D 1-8 ug、维生素E10-20 mg、维生素B11-4 mg、维生素B21-4 mg、维生素B6 1-4 mg、维生素B12 1-4 ug、维生素C10-50 mg、烟酰胺10-50 mg、泛酸2-8 mg、叶酸100-500 ug，其余成分为麦芽糊精。
其中，复合矿物质预混料由钙、镁、锌、铁组成，1 g矿物质预混料含钙20-100 mg、镁10-100 mg，锌1-5 mg、铁1-5 mg，其余成分为麦芽糊精。
优选地，含肽特殊医学用途配方食品优化为：每100 g所述全营养含肽特殊医学用途配方食品中含：
海洋鱼低聚肽14.95 g，
水解乳清蛋白9g，
抗性糊精30g，
麦芽糊精26g，
结晶果糖2g，
木糖醇5g，
柠檬酸钠0.5g，
环糊精0.5g，
亚麻籽油粉5g，
虫草多糖0.05g，
矿物质预混料5.7g，
维生素预混料0.6g，
左旋肉碱0.5g，
牛磺酸0.1g，
氯化钠0.1g。
其中，复合维生素预混料由维生素A、维生素D、维生素E、维生素B1、维生素B2、维生素B6、维生素B12、维生素C、烟酰胺、泛酸、叶酸、生物素组成，1g复合维生素预混料含维生素A800ug、维生素D3ug、维生素E14mg、维生素B11.8mg、维生素B21.8mg、维生素B61.4mg、维生素B122ug、维生素C33.3mg、烟酰胺21.6mg、泛酸4.2mg、叶酸146.7ug，其余成分为麦芽糊精。
其中，复合矿物质预混料由钙、镁、锌、铁组成,1g矿物质预混料含钙70mg、镁31mg，锌1.9mg、铁3.2mg，其余成分为麦芽糊精。
其中，全营养含肽特殊医学用途配方食品可以为粉剂或乳液。
本发明提供的全营养含肽特殊医学用途配方食品含有低聚肽、水解乳清蛋白等不同形式的氮源，易于消化吸收，对病人机体功能和胃肠道功能恢复具有重要作用。
本发明提供的全营养含肽特殊医学用途配方食品特别添加虫草多糖，有助于提升患者免疫力。
本发明提供的全营养含肽特殊医学用途配方食品采用抗性糊精等低GI的碳水化合物，有助于控制病人的血糖。
本发明提供的全营养含肽特殊医学用途配方食品是一种复合食品，低聚肽、水解乳清蛋白等不同形式的氮源，易于消化吸收，虫草多糖提升患者免疫力，低GI的碳水化合物抗性糊精，控制病人血糖，通过各种营养成分的协同作用，利用围手术期患者的部分消化功能，促进患者消化功能的全面恢复，提升患者免疫功能，增强机体抗病能力，从而加速病患的康复，且能被完全消化吸收、无渣无残留，有利于进行肠道内窥镜观察及实验。该全营养含肽特殊医学用途配方食品可为胃肠道功能障碍病人提供营养支持。
具体实施方式
下面的具体实施例对本发明进行进一步的描述。
实施例1
一种全营养含肽特殊医学用途配方食品，每100g所述全营养含肽特殊医学用途配方食品中含有：
海洋鱼低聚肽14.95g，
水解乳清蛋白9g，
抗性糊精30g，
麦芽糊精26g，
结晶果糖2g，
木糖醇5g，
柠檬酸钠0.5g，
环糊精0.5g，
亚麻籽油粉5g，
虫草多糖0.05g，
矿物质预混料5.7g，
维生素预混料 0.6g，
左旋肉碱0.5g，
牛磺酸0.1g，
氯化钠0.1g。
其中，复合维生素预混料由维生素A、维生素D、维生素E、维生素B1、维生素B2、维生素B6、维生素B12、维生素C、烟酰胺、泛酸、叶酸、生物素组成，1g复合维生素预混料含维生素A600ug、维生素D 7ug、维生素E 18mg、维生素B1 3mg、维生素B2 3mg、维生素B6 3mg、维生素B12 3ug、维生素C 15mg、烟酰胺40mg、泛酸7mg、叶酸400ug，其余成分为麦芽糊精。
其中，复合矿物质预混料由钙、镁、锌、铁组成，1g矿物质预混料含钙30mg、镁91mg，锌4mg、铁1.5mg，其余成分为麦芽糊精。
实施例2
一种全营养含肽特殊医学用途配方食品，每100g所述全营养含肽特殊医学用途配方食品中含有：
大豆低聚肽 14.95g，
水解乳清蛋白 9g，
抗性糊精30g，
麦芽糊精26g，
结晶果糖2g，
木糖醇5g，
柠檬酸钠0.5g，
环糊精0.5g，
葵花籽油5g，
虫草多糖0.05g，
矿物质预混料5.7g，
维生素预混料 0.6g，
左旋肉碱0.5g，
牛磺酸0.1g，
氯化钠0.1g。
其中，复合维生素预混料由维生素A、维生素D、维生素E、维生素B1、维生素B2、维生素B6、维生素B12、维生素C、烟酰胺、泛酸、叶酸、生物素组成，1g复合维生素预混料含维生素A800ug、维生素D3ug、维生素E14mg、维生素B11.8mg、维生素B21.8mg、维生素B61.4mg、维生素B122ug、维生素C33.3mg、烟酰胺21.6mg、泛酸4.2mg、叶酸146.7ug，其余成分为麦芽糊精。
其中，复合矿物质预混料由钙、镁、锌、铁组成，1g矿物质预混料含钙70mg、镁31mg，锌1.9mg、铁3.2mg，其余成分为麦芽糊精。
制备方法为：将所有原料加到3倍量60-70℃的水中，用剪切机剪切得乳浊液，调整均质机压力至60Mpa对乳浊液进行均质，然后进行高温灭菌，所得液体经过喷雾干燥制成粉末即得。
实施例3-6
实施例3-6与实施例1、2的不同之处在于全营养含肽特殊医学用途配方食品的组成配比不同，具体见表1。
表1 实施例3-6提供的全营养含肽特殊医学用途配方食品的组成配比 (每100g中的组成配比，单位：g)
| 原料名称 | 实施例3 | 实施例4 | 实施例5 | 实施例6 |
| 海洋鱼低聚肽 | 10 | 13 | 17 | 19 |
| 水解乳清蛋白 | 10.5 | 11 | 6 | 6.5 |
| 抗性糊精 | 20 | 24 | 35 | 39 |
| 麦芽糊精 | 39.8 | 33 | 27 | 20 |
| 结晶果糖 | 1 | 3.7 | 2 | 4.5 |
| 木糖醇 | 7.1 | 5 | 4 | 3 |
| 柠檬酸钠 | 0.2 | 0.5 | 0.8 | 0.9 |
| 环糊精 | 1 | 0.8 | 0.5 | 0.2 |
| 椰子油粉 | 1 | 2 | 1 | 3.3 |
| 虫草多糖 | 0.01 | 0.06 | 0.08 | 0.1 |
| 维生素预混料 | 1 | 0.5 | 0.8 | 0.3 |
| 矿物质预混料 | 7 | 5.5 | 5 | 3 |
| 左旋肉碱 | 0.99 | 0.7 | 0.64 | 0.1 |
| 牛磺酸 | 0.2 | 0.1 | 0.08 | 0.05 |
| 氯化钠 | 0.2 | 0.14 | 0.1 | 0.05 |
实施例7
一种全营养含肽特殊医学用途配方食品对肠炎大鼠肠道功能的影响。取实施例1-6和对比组进行试验，对比组所用食物与实施例1不同在于：用乳清蛋白代替海洋鱼低聚肽、水解乳清蛋白、且不加虫草多糖。同时设阴性对照组，阴性对照组灌胃生理盐水。SPF级葡聚糖硫酸钠(DSS)造模大鼠，形成胃肠道炎症，雌雄各半，体重75~85g，每组10只。按照0.08g/1g剂量每天灌胃大鼠，连续10天。给鼠灌胃期间单笼喂养，每天称1次体重。实验完成后，手术解剖查看大鼠肠道情况。全营养含肽特殊医学用途配方食品对大鼠体重的影响结果见表2。
表2 全营养含肽特殊医学用途配方食品对大鼠体重的影响
| 试验组 | 初体重(g) | 终体重(g) | 增重(g) |
| 实施例1 | 80.2 | 141.3 | 61.1 |
| 实施例2 | 80.5 | 143 | 62.5 |
| 实施例3 | 80.3 | 140.5 | 60.2 |
| 实施例4 | 80 | 139.6 | 59.6 |
| 实施例5 | 79.2 | 137.8 | 58.6 |
| 实施例6 | 81 | 141.3 | 60.3 |
| 对比组 | 81.3 | 110.2 | 28.9 |
| 阴性对照组 | 80.8 | 71 .6 | -9.2 |
由表2可知，与阴性对照组比较，实施例1-6组大鼠的体重明显增加；与对比组相比，实施例1-6组大鼠的体重增加更明显。可见，该制剂对肠炎大鼠体重增长有明显影响，可以提升肠炎大鼠的消化吸收功能。解剖发现，实施例1-6组大鼠的肠道与对比组相比：干净、无渣、且肠道状态有明显恢复，有利于肠道诊断检察。
Claims (9)
1.一种全营养含肽特殊医学用途配方食品，其特征在于，每100g所述全营养含肽特殊医学用途配方食品中含有：
低聚肽10-20g，
水解乳清蛋白5-11g，
抗性糊精20-40g，
麦芽糊精20-40g，
结晶果糖1-5g，
木糖醇3-8g，
柠檬酸钠0.1-1g，
环糊精0.1-1g，
植物油脂1-10g，
虫草多糖0.005-0.1g，
矿物质预混料3-7g，
维生素预混料0.2-1g，
左旋肉碱0.1-1g，
牛磺酸0.05-0.2g，
氯化钠0.05-0.2g。
2.根据权利要求1所述的全营养含肽特殊医学用途配方食品，其特征在于，所述低聚肽为海洋鱼低聚肽或大豆低聚肽。
3.根据权利要求1所述的全营养含肽特殊医学用途配方食品，其特征在于，所述植物油脂为植物油或植物油粉末。
4.根据权利要求3所述的全营养含肽特殊医学用途配方食品，其特征在于，所述植物油为椰子油、棕榈油、大豆油、葵花籽油、亚麻籽油。
5.根据权利要求1，4所述的全营养含肽特殊医学用途配方食品，其特征在于，制备方法为将所有原料加到水中、剪切、均质、灭菌、喷雾干燥制成粉末。
6.根据权利要求1，3所述的全营养含肽特殊医学用途配方食品，其特征在于，所述植物油粉为椰子油粉、棕榈油粉、大豆油粉、葵花籽油粉、亚麻籽油粉。
7.根据权利要求6所述的全营养含肽特殊医学用途配方食品，其特征在于，所述植物油粉末由植物油和麦芽糊精组成，二者的重量比为(40-60)：(40-60)，将植物油和麦芽糊精混合，喷雾干燥制成粉末即得到所述植物油粉末，植物油为椰子油、棕榈油、大豆油、葵花籽油、亚麻籽油。
8.根据权利要求1所述的全营养含肽特殊医学用途配方食品，其特征在于，每100g所述全营养含肽特殊医学用途配方食品中含有：
海洋鱼低聚肽14.95g，
水解乳清蛋白9g，
抗性糊精30g，
麦芽糊精26g，
结晶果糖2g，
木糖醇5g，
柠檬酸钠0.5g，
环糊精0.5g，
亚麻籽油粉5g，
虫草多糖0.05g，
矿物质预混料5.7g，
维生素预混料0.6g，
左旋肉碱0.5g，
牛磺酸0.1g，
氯化钠0.1g。
9.根据权利要求1、8中任一权利要求所述的全营养含肽特殊医学用途配方食品，其特征在于，所述复合维生素预混料由维生素A、维生素D、维生素E、维生素B1、维生素B2、维生素B6、维生素B12、维生素C、烟酰胺、泛酸、叶酸、生物素组成，1g复合维生素预混料含维生素A400-1000ug、维生素D 1-8ug、维生素E 10-20mg、维生素B1 1-4mg、维生素B2 1-4mg、维生素B6 1-4mg、维生素B12 1-4ug、维生素C 10-50mg、烟酰胺10-50mg、泛酸2-8mg、叶酸100-500ug，其余成分为麦芽糊精；所述复合矿物质预混料由钙、镁、锌、铁组成，1g矿物质预混料含钙20-100mg、镁10-100mg，锌1-5mg、铁1-5mg，其余成分为麦芽糊精。
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