CN110515114A - Cherenkov's optical acquisition device and acquisition method in a kind of high-performance Patients During Radiotherapy - Google Patents
Cherenkov's optical acquisition device and acquisition method in a kind of high-performance Patients During Radiotherapy Download PDFInfo
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- CN110515114A CN110515114A CN201910788549.4A CN201910788549A CN110515114A CN 110515114 A CN110515114 A CN 110515114A CN 201910788549 A CN201910788549 A CN 201910788549A CN 110515114 A CN110515114 A CN 110515114A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
- G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
- G01T1/16—Measuring radiation intensity
- G01T1/22—Measuring radiation intensity with Cerenkov detectors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
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Abstract
Cherenkov's optical acquisition device and acquisition method in a kind of high-performance Patients During Radiotherapy, the bandpass filter of Cherenkov's signal including acquisition, high pass light quantity imaging lens are provided on bandpass filter, high pass light quantity imaging lens have big light-inletting quantity for acquisition device, bandpass filter rear end is provided with high-energy ray shielding cabin, high-energy ray shielding is provided with the image intensifier that signal is carried out for enhancing Cherenkov light at the top of cabin, image intensifier output end is sequentially connected relaying camera lens, photodetector and high-pressure modular, high-energy ray shielding bilge portion is provided with tfi module.The present invention has the characteristics that measurement accuracy is high, structure is simple.
Description
Technical field
The present invention relates to optical technical field, in particular to Cherenkov's optical acquisition device in a kind of high-performance Patients During Radiotherapy
And acquisition method.
Background technique
Cerenkov radiation (Cerenkov Radiation, CR) refers to that high speed charged particle is run through in antivacuum medium
Cheng Zhong, particle rapidity be greater than light in the medium the speed of service when, generate local polarisation in the direction of motion path, and returning to
Visible light and near-infrared photon can be discharged during equilibrium state.It also will appear CR in biological tissue when radioactive ray particle enters
Cerenkov radiation is applied to biomedical imaging domain variability for the first time and proposes that Cherenkov light shines by phenomenon, Robertson etc.
(Cerenkov Luminescence Imaging, CLI) this concept is imaged.CLI has the advantages that many optics imagings such as nothing
Radiation injury, image taking speed be fast, it is high-throughput, cheap, have a wide range of application, especially can be used to monitoring Patients During Radiotherapy tissue
In dosage.
But high-energy ray is a kind of very faint optical signal by Cherenkov's optical signal produced by biological tissue,
Its intensity is probably 10-6~10-9W/cm2, while the wavelength of Cherenkov light is concentrated mainly on the short wavelength region of royal purple, biology
Tissue has very strong absorption to it, and only a small amount of Cherenkov's optical signal caused by tissue superficial can penetrate group
It knits and is collected and obtains, therefore it is very faint really to be able to the collected Cherenkov's optical signal being imaged, and has and produce
Raw instantaneity, vulnerable to ambient light interference the features such as, while in Patients During Radiotherapy in the collection process of Cherenkov's optical signal, high energy
Ray can damage the photosensitive element and subsidiary components of cli data acquisition device, if the exposure of cli data acquisition device camera
Under the high-energy ray of high dose, it can be damaged quickly.Another aspect high-energy ray itself can make cli data acquisition dress
The photosensitive element set obtains the response for being much higher than Cherenkov's optical signal.Therefore research and development have putting for highly sensitive high time resolution
Treating Cherenkov's signal pickup assembly is a key technology problem urgently to be resolved.
Summary of the invention
In order to solve the above technical problems, the purpose of the present invention is to provide Cherenkovs in a kind of high-performance Patients During Radiotherapy
Optical acquisition device and acquisition method have the characteristics that measurement accuracy is high, structure is simple.
To achieve the goals above, the technical solution adopted by the present invention is that:
Cherenkov's optical acquisition device in a kind of high-performance Patients During Radiotherapy, the bandpass filtering including acquiring Cherenkov's signal
Device 1 is provided with high pass light quantity imaging lens 2 on bandpass filter 1, and high pass light quantity imaging lens 2 are for guaranteeing that acquisition device has
There is big light-inletting quantity, 1 rear end of bandpass filter is provided with high-energy ray shielding cabin 9, high-energy ray shielding is arranged at the top of cabin 9
Have for enhance Cherenkov light carry out signal image intensifier, the image intensifier output end be sequentially connected relaying camera lens 6,
Photodetector 7 and high-pressure modular 8 are provided with tfi module 10 positioned at high-energy ray shielding 9 bottom of cabin, and tfi module 10 is used for
The switching gate function of image intensifier.
The image intensifier includes time grade 3, microchannel plate 4 and the fluorescent screen 5 set gradually.
The optical information that the relaying camera lens 6 is responsible for after enhancing image intensifier is coupled to highly sensitive photodetection
On device 7, photodetector 7 converts optical signal into electric signal output.
The high-pressure modular 8 provides high pressure for the microchannel plate of image intensifier, controls the gain of image intensifier.
The high-energy ray shielding cabin 9 is by there is the lead of high-selenium corn characteristic or tungsten material to be made ray.
The bandpass filter 1 uses the high-performance narrow band filter slice of 400-650nm.
The tfi module 10 obtains time-series image using sequence acquisition mode, then carries out temporal filtering,
It is eliminated using time stochastic behaviour.
Cherenkov light acquisition method in a kind of novel high-performance Patients During Radiotherapy, comprising the following steps:
When clinac treats patient, tfi module 10 combines the synchronous control circuit in system to pass through
Unified agreement guarantees that cli data acquisition device only goes out the beam moment (about 3 μ s) opening image intensifier in accelerator ray and adopted
Collection；
Acquisition first passes around the bandpass filter of 400-650nm bandpass filter 1 after starting, carry out CLI Image Acquisition；
Large-numerical aperture imaging lens guarantee that acquisition device has big light-inletting quantity, improve the detection performance of package unit；
Image intensifier carries out signal enhancing (several hundred to 1000 times) to the Cherenkov light received, to effectively improve this
The detectability of device small-signal；
Cherenkov's optical information that relaying camera lens 6 is responsible for after enhancing image intensifier is coupled to subsequent high sensitivity
On photodetector 7；
Photodetector 7 converts optical signal into electric signal output, passes to System control computer；
The microchannel plate that high-pressure modular 8 is responsible for image intensifier provides high pressure, controls the gain of image intensifier.
Beneficial effects of the present invention:
1, tfi module 10 of the present invention obtains time-series image using sequence acquisition mode, then carries out time-domain filter
Wave is eliminated using time stochastic behaviour, the interference of the signal at other moment when solving acquisition signal；
2, the present invention is according to the spectral characteristic of Cherenkov's signal, select the high-performance narrow band filter slice of 400-650nm into
Row CLI Image Acquisition is filtered out while effectively obtaining Cherenkov's signal using high performance band pass filter gating characteristics
The influence of other wave band light.
3, the present invention shields cabin using the lead or tungsten material production high-energy ray to ray with high-selenium corn characteristic, prevents height
Damage of the energy ray to camera, while impulsive noise caused by high-energy ray excitation photodetector can be reduced.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of apparatus of the present invention.
Fig. 2 is cli data acquisition device schematic diagram.
Specific embodiment
Below with reference to embodiment, invention is further described in detail.
Cherenkov's optical acquisition device in a kind of high-performance Patients During Radiotherapy as shown in Figure 1:, Cherenkov's letter including acquisition
Number bandpass filter 1, high pass light quantity imaging lens 2 are provided on bandpass filter 1, high pass light quantity imaging lens 2 are for adopting
Acquisition means have big light-inletting quantity, 1 rear end of bandpass filter are provided with high-energy ray shielding cabin 9, high-energy ray shields cabin 9
Top is provided with the image intensifier that signal is carried out for enhancing Cherenkov light, during the image intensifier output end is sequentially connected
After camera lens 6, photodetector 7 and high-pressure modular 8, high-energy ray shielding 9 bottom of cabin is provided with tfi module 10.
The image intensifier successively includes time grade 3, microchannel plate 4 and fluorescent screen composition 5.
The optical information that the relaying camera lens 6 is responsible for after enhancing image intensifier is coupled to the light of subsequent high sensitivity
On electric explorer 7, then photodetector 7 converts optical signal into electric signal output again.
The microchannel plate that the high-pressure modular 8 is responsible for image intensifier provides high pressure, controls the gain of image intensifier.
The high-energy ray shielding cabin 9 is by there is the lead of high-selenium corn characteristic or tungsten material to be made ray.
Bandpass filter 1, bandpass filter with high performance are responsible for Cherenkov's signal gating of quasi- acquisition, are eliminated
The influence of other spectral coverage environment light；
High pass light quantity imaging lens 2 are large-numerical aperture imaging lens, guarantee that acquisition device has big light-inletting quantity, mention
The detection performance of high package unit；
The image intensifier carries out signal enhancing (several hundred to 1000 times) to the Cherenkov light received, to effectively mention
The detectability of the high device small-signal.(being made of 3. time grade 4. microchannel plate, 5. fluorescent screen)
The optical information that relaying camera lens 6 is responsible for after enhancing image intensifier is coupled to the photodetection of subsequent high sensitivity
On device 7, then photodetector 7 converts optical signal into electric signal output again；
The microchannel plate that the high-pressure modular 8 is responsible for image intensifier provides high pressure, controls the gain of image intensifier.
The high-energy ray shielding cabin 9 is set simultaneously by there is the lead of high-selenium corn characteristic or tungsten material to be made ray
The ventilation cooling system of meter response ensures camera normal working temperature.
The tfi module 10 is used for the switching gate function of image intensifier, in conjunction with the synchronous control circuit in system, protects
Card cli data acquisition device only opens image intensifier in accelerator ray outgoing moment (about 3 μ s) and acquires Cherenkov light, when
Organism surface does not have Cherenkov light when no ray projects, and the image intensifier of cli data acquisition device is in close state, avoids
External stray light enters；
In the collection process of Cherenkov's optical signal, high-energy ray shielding cabin can effectively prevent high-energy ray to camera
Damage, while reducing impulsive noise caused by high-energy ray excitation photodetector.
It is as shown in Figure 2: Cherenkov light acquisition method in a kind of novel high-performance Patients During Radiotherapy, comprising the following steps:
When clinac treats patient, tfi module 10 combines the synchronous control circuit in system to pass through
Unified agreement guarantees that cli data acquisition device only goes out the beam moment (about 3 μ s) opening image intensifier in accelerator ray and adopted
Collection；
Acquisition first passes around the bandpass filter of 400-650nm bandpass filter 1 after starting, carry out CLI Image Acquisition；
Large-numerical aperture imaging lens guarantee that acquisition device has big light-inletting quantity, improve the detection performance of package unit；
Image intensifier carries out signal enhancing (several hundred to 1000 times) to the Cherenkov light received, to effectively improve this
The detectability of device small-signal；
Cherenkov's optical information that relaying camera lens 6 is responsible for after enhancing image intensifier is coupled to subsequent high sensitivity
On photodetector 7；
Photodetector 7 converts optical signal into electric signal output, passes to System control computer；
The microchannel plate that high-pressure modular 8 is responsible for image intensifier provides high pressure, controls the gain of image intensifier.
Claims (8)
1. Cherenkov's optical acquisition device in a kind of high-performance Patients During Radiotherapy, which is characterized in that Cherenkov's letter including acquisition
Number bandpass filter (1), be provided with high pass light quantity imaging lens (2), high pass light quantity imaging lens on bandpass filter (1)
(2) for guaranteeing that acquisition device has big light-inletting quantity, it is located at bandpass filter (1) rear end and is provided with high-energy ray shielding cabin
(9), the image intensifier that signal is carried out for enhancing Cherenkov light, the picture are provided at the top of high-energy ray shielding cabin (9)
Booster output end is sequentially connected relaying camera lens (6), photodetector (7) and high-pressure modular (8), is located at high-energy ray and shields cabin
(9) bottom is provided with tfi module (10), and tfi module 10 is used for the switching gate function of image intensifier.
2. Cherenkov's optical acquisition device in a kind of high-performance Patients During Radiotherapy according to claim 1, which is characterized in that institute
The image intensifier stated includes time grade (3), microchannel plate (4) and the fluorescent screen (5) set gradually.
3. Cherenkov's optical acquisition device in a kind of high-performance Patients During Radiotherapy according to claim 1, which is characterized in that institute
The optical information that the relaying camera lens (6) stated is responsible for after enhancing image intensifier is coupled on highly sensitive photodetector (7),
Photodetector (7) converts optical signal into electric signal output.
4. Cherenkov's optical acquisition device in a kind of high-performance Patients During Radiotherapy according to claim 1, which is characterized in that institute
The high-pressure modular (8) stated provides high pressure for the microchannel plate of image intensifier.
5. Cherenkov's optical acquisition device in a kind of high-performance Patients During Radiotherapy according to claim 1, which is characterized in that institute
High-energy ray shielding cabin (9) is stated by there is the lead of high-selenium corn characteristic or tungsten material to be made ray.
6. Cherenkov's optical acquisition device in a kind of high-performance Patients During Radiotherapy according to claim 1, which is characterized in that institute
The bandpass filter (1) stated uses the high-performance narrow band filter slice of 400-650nm.
7. Cherenkov's optical acquisition device in a kind of high-performance Patients During Radiotherapy according to claim 1, which is characterized in that institute
The tfi module (10) stated obtains time-series image using sequence acquisition mode, then carries out temporal filtering, utilizes the time
Stochastic behaviour is eliminated.
8. Cherenkov light acquisition method in a kind of high-performance Patients During Radiotherapy, which comprises the following steps:
When clinac treats patient, tfi module (10) combines the synchronous control circuit in system to pass through system
One agreement guarantees that cli data acquisition device only goes out beam moment opening image intensifier in accelerator ray and is acquired；
Acquisition first passes around the bandpass filter of 400-650nm bandpass filter (1) after starting, carry out CLI Image Acquisition；
Large-numerical aperture imaging lens guarantee that acquisition device has big light-inletting quantity, improve the detection performance of package unit；
Image intensifier carries out signal enhancing to the Cherenkov light received；
Cherenkov's optical information that relaying camera lens (6) is responsible for after enhancing image intensifier is coupled to the light of subsequent high sensitivity
On electric explorer (7)；
Photodetector (7) converts optical signal into electric signal output, passes to System control computer；
The microchannel plate that high-pressure modular (8) is responsible for image intensifier provides high pressure, controls the gain of image intensifier.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111190217A (en) * | 2020-01-23 | 2020-05-22 | 中国工程物理研究院激光聚变研究中心 | Transmission band-pass type radiation flow detector |
| CN111759282A (en) * | 2020-07-09 | 2020-10-13 | 苏州锐一仪器科技有限公司 | Cherenkov fluorescence imaging device and medical imaging system |
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