CN110447547A - Sterilized isolator - Google Patents
Sterilized isolator Download PDFInfo
- Publication number
- CN110447547A CN110447547A CN201910853274.8A CN201910853274A CN110447547A CN 110447547 A CN110447547 A CN 110447547A CN 201910853274 A CN201910853274 A CN 201910853274A CN 110447547 A CN110447547 A CN 110447547A
- Authority
- CN
- China
- Prior art keywords
- isolation
- packet
- air inlet
- filter fan
- air
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002955 isolation Methods 0.000 claims abstract description 68
- 239000000463 material Substances 0.000 claims description 6
- 229920006264 polyurethane film Polymers 0.000 claims description 6
- 229920001971 elastomer Polymers 0.000 claims description 5
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 14
- 238000013461 design Methods 0.000 abstract description 7
- 238000012546 transfer Methods 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 9
- 238000010586 diagram Methods 0.000 description 5
- 238000010171 animal model Methods 0.000 description 4
- 238000009423 ventilation Methods 0.000 description 4
- 230000003749 cleanliness Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 238000003975 animal breeding Methods 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
- B01D46/54—Particle separators, e.g. dust precipitators, using ultra-fine filter sheets or diaphragms
- B01D46/543—Particle separators, e.g. dust precipitators, using ultra-fine filter sheets or diaphragms using membranes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Filtering Of Dispersed Particles In Gases (AREA)
Abstract
A kind of claimed Sterilized isolator; including bracket and at least one isolation packet being placed in the bracket; wherein; air inlet is equipped in isolation packet side; the other side sets out air port, and the isolation packet is outer to be additionally provided with blower and primary filter, air inlet filter fan, outlet air filter fan, total intake stack;Wherein, by total intake stack connection air inlet filter fan, the outlet air end for entering the wind filter fan connects the air inlet of the isolation packet for the blower and primary filter;The air outlet of the isolation packet connects outlet air filter fan, and valve is equipped on total intake stack.Isolator airtightness of the present invention is good, and sufficiently sterilizing means can be used to guarantee the aseptic result that packet internal environment is isolated.Design details improvement of the present invention surprisingly breaks ring caused by isolation packet is effectively reduced in operation or transfer.
Description
Technical field
The present invention relates to field of biotechnology, and in particular to germfree animal breeding apparatus refers in particular to be suitable for raising nothing
The Sterilized isolator of bacterium mouse.
Background technique
With the fast development of biological medicine industry and life science, the demand of annual experimental animal is not yet
It is disconnected to increase, usage amount is maximum be exactly muroid experimental animal.Sterile grade experimental animal is the experiment of control of microorganisms grade highest
Animal is widely used in the multiple fields of the subjects such as life science, animal and veterinary, Food Science and medicine.As sterile
The key equipment of animal feeding --- Sterilized isolator is infrastructure device indispensable in germfree animal research.It is required that raising
The environment of germfree animal must be it is controllable, can sterilization and reusable, to guarantee experimental animal not by external environment
Variation and the influence of microorganism.
Summary of the invention
The object of the present invention is to provide a kind of isolator of sterilizing sufficiently, safe and reliable, easy to operate.
A kind of Sterilized isolator of the invention, including bracket and at least one isolation packet being placed in the bracket, wherein
It is equipped with air inlet in isolation packet side, the other side sets out air port, and the isolation packet is outer to be additionally provided with blower and first
Imitate filter, air inlet filter fan, outlet air filter fan, total intake stack;
Wherein, the blower and primary filter were entered the wind by total intake stack connection air inlet filter fan
The outlet air end of filter ventilator connects the air inlet of the isolation packet;The air outlet of the isolation packet connects outlet air filter fan,
And valve is equipped on total intake stack.
Side is equipped at least one isolation packet on the bracket, and at least one isolation packet is equipped in the bracket, leads to
It crosses total intake stack and connects each branch's intake stack that packet is isolated to its air inlet filter fan, and in each branch's blast pipe
Road is designed with valve.
It is wrapped in the isolation and is additionally provided with delivery bin and transmitting bin bracket;Inner overcap is respectively equipped in the delivery bin two sides
With outer cap sealed, inner overcap is located at the side that delivery bin leads to isolation packet, and outer nut cap is located at delivery bin and leads to extraneous side,
Inner overcap is fixed by three rubber ring overlappings.
Cage is provided in isolation packet, and the corner of cage two sides fixed plate uses mellow and full smooth structure, avoids
Scratch isolation packet.
It is wrapped in the isolation and is equipped with cushion between bottom and bracket.
The isolation packet is made of polyurethane film, and is sutured in the splicing of material polyurethane film using double slit, and really
Guarantor can maintain reveal without obvious at least 48 hours under 1000pa pressure difference.The polyurethane film transparency is good, facilitates operation and sight
Examine the activity condition that interior animal is wrapped in isolation.Polyurethane film has stronger puncture resistant and tear resistance, prevents contingency
Caused by pollute.
The air inlet filter fan and outlet air filter fan are all stainless steel material, can pass through high pressure steam sterilization
Mode is thoroughly sterilized, and guarantees the air cleanliness for entering isolation packet by entering the wind filter fan.
The frame bottom of the isolator is equipped with the locking structure of four-wheel.
Isolator external connection mouth not additional in addition to delivery bin and inlet and outlet.
The isolator can be dismantled easily after use and carry out the cleaning and disinfection at no dead angle.
The isolator is using 1 opening directly communicated with the outside world for only retaining the outer nut cap of delivery bin.
Isolator airtightness of the present invention is good, and sufficiently sterilizing means can be used to guarantee the sterile effect that packet internal environment is isolated
Fruit.Design details improvement of the present invention surprisingly breaks ring caused by isolation packet is effectively reduced in operation or transfer;Present invention design is filled
Divide and utilize space, convenient for operation, improves the efficiency of user.The present invention design can be obtained it is a kind of sterilizing sufficiently, securely and reliably, behaviour
Make convenient novel practical isolator.
Isolation packet delivery bin two sides of the invention are respectively equipped with inner overcap and outer cap sealed, and inner overcap is logical positioned at delivery bin
To the side of isolation packet, outer nut cap is located at delivery bin and leads to extraneous side, and inner overcap is fixed by three rubber ring overlappings, guaranteed
Isolation is wrapped interior environment and is thoroughly completely cut off with external environment.Delivery bin is passed through in article disengaging, and the alternating of inside and outside nut cap is opened, outside delivery bin
Nut cap increases length on traditional infrastructure, can the biggish article of receiving volume be put into delivery bin.
The internal sterile subenvironment obtained by sterilizing is had collarium border complete by sterile isolation packet using physical isolation with the external world
It is complete to be isolated, and ensure to keep interior environment sterile in regular job by setting high efficiency particle air filter and isolation gloves.
Detailed description of the invention
Fig. 1 is the rearview of one embodiment of Sterilized isolator of the present invention.
Fig. 2 is the front view of one embodiment of Sterilized isolator of the present invention.
Fig. 3 is the schematic diagram that Sterilized isolator of the present invention ventilation uses.
Fig. 4 is Sterilized isolator ventilation filter schematic diagram of the present invention.
Fig. 5 A is the cage schematic diagram in the isolation packet of Sterilized isolator;Fig. 5 B is that isolation packet rearview shows cage and passes
Pass bin location;Fig. 5 C is isolation packet front view cage position view.
Wherein, 10 isolation packet, 18 brackets, 19 brake casters, 1 blower and primary filter, 2 total intake stacks, 22 branches
12 valve of intake stack, 3 air inlet filter fans, 4 outlet air filter fans, 5 delivery bins, 6 transmitting bin brackets, 7 cushions, 8
Two packet cages, 9 gloves lassos, 11 cages, 13 filter fan top ducts opening, 14 filter fan inner core main bodys, 15
Filter fan inner core bottom, 16 filter fan housings, 17 filter fan housings opening.
Specific embodiment
Above scheme is described further below in conjunction with specific embodiment.It should be understood that these embodiments are for illustrating
The present invention rather than limit the scope of the invention.Implementation condition used in the examples can be done according to the condition of specific producer
Further adjustment, the implementation condition being not specified is usually the condition in routine experiment.
Sterilized isolator of the invention as shown in Fig.1 and Fig.2, including bracket 18 and be placed in the bracket 18 one every
From packet 10, air inlet is offered in 10 sides of isolation packet, the other side is equipped with air outlet, and blower and just effect are additionally provided with outside isolation packet 10
Filter 1, air inlet filter fan 3, outlet air filter fan 4, total intake stack 2;Wherein, blower and primary filter 1 are logical
The total connection of intake stack 2 air inlet filter fan 3 is crossed, the outlet air end of air inlet filter fan 3 connects air inlet;Air outlet connection
Outlet air filter fan 4, and valve 12 is equipped on total intake stack 2;It is wrapped in isolation and is additionally provided with delivery bin 5 and delivery bin branch
Frame 6;It is respectively equipped with inner overcap and outer cap sealed in 5 two sides of delivery bin, inner overcap is located at delivery bin 5 and leads to isolation packet 10
Side, outer nut cap is located at delivery bin 5 and leads to extraneous side, and inner overcap is fixed by three rubber rings overlappings, in the present embodiment
In, it is equipped with an isolation packet 10 in bracket 8, an isolation packet 10 is additionally provided on bracket 8, is connected by total intake stack 2
The air inlet filter fan 3 of isolation packet on branch's blast pipe 22 to bracket, and valve 12 is equipped in branch's intake stack 22.
In this way, in practice, controlling air-flow opening and closing by the connection of branch's blast pipe and valve, can splicing as more as possible
Isolation packet.Be equipped with cushion 7 between isolation 10 bottoms of packet and bracket 18, be effectively reduced isolation wrap in article when inadvertently falling off
Caused by destroy.
The schematic diagram of Sterilized isolator ventilation behaviour in service as shown in Figure 3, passes through the connection and valve control of intake stack
The blast pipe of the isolation packet of lower layer can be connected with the blast pipe of upper layer isolation packet, theoretically, can be spliced by air-flow opening and closing processed
Infinite number of isolation packet.
Further, the content includes following aspect:
The Filter column of air inlet filter fan 3 and outlet air filter fan 4 as shown in Figure 4 is by inner core and 16 groups of housing
At, be all made of stainless steel material production.Inner core bottom 15 is closed, and inner core main body 14 is hollow design, and body exterior package is efficient
Air-filtering membrane, top are equipped with pipeline tapping 13, for connecting isolation packet air inlet or air outlet;Housing 16 is designed as pedestal and outer
It is closed to cover shaft welding, housing shaft has cylinder opening 17, for connecting intake stack or direct air draft.
Fig. 5 A is the cage schematic diagram in the isolation packet of Sterilized isolator;Fig. 5 B is that isolation packet rearview shows cage and passes
Pass bin location;Fig. 5 C is isolation packet front view cage position view.Shown in tetrad pouch-type fexible film isolator
The design of cage fixed plate, which is used, makes full use of space close to delivery bin and operating gloves side shape for arc, and facilitates operation.
The outer nut cap of delivery bin has an opening, uses for packet air tightness test and spraying disinfection liquid to be isolated.Animal, feeding
Material, drinking-water and various apparatus are entered and left by delivery bin, and two nut cap interactions are opened;Filter fan is after high pressure steam sterilization
Be assembled on isolator, air enters intake stack by external blower and primary filter, by air inlet filter fan into
Enter in isolation packet, guarantees the cleanliness of air in isolation packet.
Delivery bin is passed through in article disengaging, and the alternating of inside and outside nut cap is opened, and inner overcap is fixed by three rubber ring overlappings, guarantees
Isolation is wrapped interior environment and is thoroughly completely cut off with external environment.The outer nut cap of delivery bin increases length on traditional infrastructure, can receiving volume compared with
Big article is put into delivery bin.
Isolator design increases the foam pad of one layer of cushion, and isolation packet is outer to be laid with one layer of soft thin pad, plays buffering and makees
With.
Distance increases between tetrad pouch-type fexible film isolator delivery bin and ventilation column, facilitates and sterilizes behaviour outside delivery bin
Make.
The outer nut cap of the isolator delivery bin of the utility model has an opening, for packet air tightness test and spraying disinfection liquid to be isolated
It uses.Animal, feed, drinking-water and various apparatus are entered and left by delivery bin, and two nut cap interactions are opened;Filter fan is through height
Pressure steam sterilizing after be assembled on isolator, air enters intake stack by air blower, by air inlet filter fan into every
From the cleanliness in packet, guaranteeing air in isolation packet.
The Sterilized isolator airtightness of the utility model is good, and air inlet and the outlet filter fan passes through high pressure steam sterilization mode
It is assembled after sterilizing, inside uses Clidox thimerosal spraying disinfection, and sterilizing methods are simple and reliable.The present invention is isolated in tradition
On the basis of device, the structure of air inlet/outlet filter fan is innovated, it is convenient to be carried out by way of high pressure steam sterilization thoroughly
The hidden danger of conventional separators air inlet pollution is eliminated in sterilizing.The risk of isolator bale broken and pollution is effectively reduced in the isolator.Entirely
Isolator reaches gnotobasis, accomplishes the complete isolation of germfree animal and nature microorganism.
Obviously, above-described embodiment is just for the sake of clearly demonstrating examples of the invention, and being not is to the present invention
The restriction of embodiment can also make on the basis of the above description for those of ordinary skill in the art
Other various forms of variations or variation here can not be exhaustive all embodiments, all to belong to skill of the invention
The obvious changes or variations that art scheme is extended out are still in the scope of protection of the present invention.
Claims (9)
1. a kind of Sterilized isolator, including bracket and at least one isolation packet being placed in the bracket, which is characterized in that
It is equipped with air inlet in isolation packet side, the other side sets out air port, and the isolation packet is outer to be additionally provided with blower and just imitated
Filter, air inlet filter fan, outlet air filter fan, total intake stack;
Wherein, by total intake stack connection air inlet filter fan, air inlet filtering is logical for the blower and primary filter
The outlet air end of wind device connects the air inlet of the isolation packet;The air outlet connection outlet air filter fan of the isolation packet, and
Total intake stack is equipped with valve.
2. Sterilized isolator according to claim 1, which is characterized in that side is equipped at least one isolation on the bracket
Packet, and at least one isolation packet is equipped in the bracket, branch's blast pipe of each isolation packet is connected by total intake stack
Filter fan is entered the wind to it in road, and is designed with valve in each branch's intake stack.
3. Sterilized isolator according to claim 1, which is characterized in that wrapped in the isolation and be additionally provided with delivery bin and biography
Pass bin bracket;It is respectively equipped with inner overcap and outer cap sealed in the delivery bin two sides, inner overcap is located at delivery bin and leads to isolation
The side of packet, outer nut cap are located at delivery bin and lead to extraneous side, and inner overcap is fixed by three rubber ring overlappings.
4. Sterilized isolator according to claim 1, which is characterized in that be provided with cage, and cage in isolation packet
The corner of frame two sides fixed plate uses mellow and full smooth structure.
5. Sterilized isolator according to claim 3, which is characterized in that wrap in the isolation and be equipped between bottom and bracket
Cushion.
6. Sterilized isolator according to claim 1, which is characterized in that the isolation packet is made of polyurethane film, and
It is sutured in the splicing of material polyurethane film using double slit.
7. Sterilized isolator according to claim 1-6, which is characterized in that the air inlet filter fan and go out
Wind filter fan is all stainless steel material.
8. Sterilized isolator according to claim 1, which is characterized in that the frame bottom of the isolator is equipped with four-wheel
Locking structure.
9. Sterilized isolator according to claim 1, which is characterized in that the isolator except delivery bin and inlet and outlet with
Outer not additional external connection mouth.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910853274.8A CN110447547A (en) | 2019-09-10 | 2019-09-10 | Sterilized isolator |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910853274.8A CN110447547A (en) | 2019-09-10 | 2019-09-10 | Sterilized isolator |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110447547A true CN110447547A (en) | 2019-11-15 |
Family
ID=68491467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910853274.8A Pending CN110447547A (en) | 2019-09-10 | 2019-09-10 | Sterilized isolator |
Country Status (1)
Country | Link |
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CN (1) | CN110447547A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113229157A (en) * | 2021-05-26 | 2021-08-10 | 深圳净拓生物科技有限公司 | Aseptic animal isolator |
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CN2441310Y (en) * | 2000-09-21 | 2001-08-08 | 上海天环科技发展有限公司 | Top cover type single air exchanging cage box |
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CN2824560Y (en) * | 2005-10-11 | 2006-10-11 | 中国医学科学院实验动物研究所 | Asepsis isolator |
CN201393455Y (en) * | 2009-04-20 | 2010-02-03 | 浙江省医学科学院 | Aseptic isolator |
CN204579435U (en) * | 2015-02-13 | 2015-08-26 | 北京维通利华实验动物技术有限公司 | A kind of animal for research Sterilized isolator |
CN105107281A (en) * | 2015-07-27 | 2015-12-02 | 汪清明 | Air cleaning device employing filter screen and air vents |
CN105684920A (en) * | 2016-03-23 | 2016-06-22 | 山东新华医疗器械股份有限公司 | Breed conservation isolator for genetic engineering mice |
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CN207574254U (en) * | 2017-11-16 | 2018-07-06 | 吴江振达净化工程有限公司 | A kind of animal raising box |
CN207678573U (en) * | 2017-11-02 | 2018-08-03 | 深圳市前海金卓生物技术有限公司 | Isolating device |
CN207733403U (en) * | 2017-12-19 | 2018-08-17 | 广东药科大学 | A kind of small-size multifunction isolating device for preventing infection of experimental animal |
CN210641875U (en) * | 2019-09-10 | 2020-06-02 | 赛业(苏州)生物科技有限公司 | Sterile isolator |
-
2019
- 2019-09-10 CN CN201910853274.8A patent/CN110447547A/en active Pending
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CN2441310Y (en) * | 2000-09-21 | 2001-08-08 | 上海天环科技发展有限公司 | Top cover type single air exchanging cage box |
CN2501308Y (en) * | 2001-09-17 | 2002-07-24 | 陈闻天 | Single air-interchanging cage with high efficient filter |
CN2824560Y (en) * | 2005-10-11 | 2006-10-11 | 中国医学科学院实验动物研究所 | Asepsis isolator |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113229157A (en) * | 2021-05-26 | 2021-08-10 | 深圳净拓生物科技有限公司 | Aseptic animal isolator |
CN113229157B (en) * | 2021-05-26 | 2022-06-28 | 深圳净拓生物科技有限公司 | Aseptic animal isolator |
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Effective date of registration: 20230117 Address after: 215400 No. 69, Zhenxi Road, Shaxi Town, Taicang City, Suzhou City, Jiangsu Province Applicant after: CYAGEN BIOSCIENCES Inc. SUZHOU Address before: No. 162, Renmin South Road, Taicang, Suzhou, Jiangsu 215000 Applicant before: CYAGEN BIOSCIENCES Inc. SUZHOU Applicant before: CYAGEN MODE BIOLOGY RESEARCH CENTER (TAICANG) Co.,Ltd. |