CN110447547A - Sterilized isolator - Google Patents

Sterilized isolator Download PDF

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Publication number
CN110447547A
CN110447547A CN201910853274.8A CN201910853274A CN110447547A CN 110447547 A CN110447547 A CN 110447547A CN 201910853274 A CN201910853274 A CN 201910853274A CN 110447547 A CN110447547 A CN 110447547A
Authority
CN
China
Prior art keywords
isolation
packet
air inlet
filter fan
air
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910853274.8A
Other languages
Chinese (zh)
Inventor
方明
张征
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cyagen Biosciences Inc Suzhou
Original Assignee
Competition Model Biological Research Center (taicang) Co Ltd
SAIYE (SUZHOU) BIOTECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Competition Model Biological Research Center (taicang) Co Ltd, SAIYE (SUZHOU) BIOTECHNOLOGY Co Ltd filed Critical Competition Model Biological Research Center (taicang) Co Ltd
Priority to CN201910853274.8A priority Critical patent/CN110447547A/en
Publication of CN110447547A publication Critical patent/CN110447547A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00Housing animals; Equipment therefor
    • A01K1/02Pigsties; Dog-kennels; Rabbit-hutches or the like
    • A01K1/03Housing for domestic or laboratory animals
    • A01K1/031Cages for laboratory animals; Cages for measuring metabolism of animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K1/00Housing animals; Equipment therefor
    • A01K1/02Pigsties; Dog-kennels; Rabbit-hutches or the like
    • A01K1/035Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D46/00Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/54Particle separators, e.g. dust precipitators, using ultra-fine filter sheets or diaphragms
    • B01D46/543Particle separators, e.g. dust precipitators, using ultra-fine filter sheets or diaphragms using membranes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Filtering Of Dispersed Particles In Gases (AREA)

Abstract

A kind of claimed Sterilized isolator; including bracket and at least one isolation packet being placed in the bracket; wherein; air inlet is equipped in isolation packet side; the other side sets out air port, and the isolation packet is outer to be additionally provided with blower and primary filter, air inlet filter fan, outlet air filter fan, total intake stack;Wherein, by total intake stack connection air inlet filter fan, the outlet air end for entering the wind filter fan connects the air inlet of the isolation packet for the blower and primary filter;The air outlet of the isolation packet connects outlet air filter fan, and valve is equipped on total intake stack.Isolator airtightness of the present invention is good, and sufficiently sterilizing means can be used to guarantee the aseptic result that packet internal environment is isolated.Design details improvement of the present invention surprisingly breaks ring caused by isolation packet is effectively reduced in operation or transfer.

Description

Sterilized isolator
Technical field
The present invention relates to field of biotechnology, and in particular to germfree animal breeding apparatus refers in particular to be suitable for raising nothing The Sterilized isolator of bacterium mouse.
Background technique
With the fast development of biological medicine industry and life science, the demand of annual experimental animal is not yet It is disconnected to increase, usage amount is maximum be exactly muroid experimental animal.Sterile grade experimental animal is the experiment of control of microorganisms grade highest Animal is widely used in the multiple fields of the subjects such as life science, animal and veterinary, Food Science and medicine.As sterile The key equipment of animal feeding --- Sterilized isolator is infrastructure device indispensable in germfree animal research.It is required that raising The environment of germfree animal must be it is controllable, can sterilization and reusable, to guarantee experimental animal not by external environment Variation and the influence of microorganism.
Summary of the invention
The object of the present invention is to provide a kind of isolator of sterilizing sufficiently, safe and reliable, easy to operate.
A kind of Sterilized isolator of the invention, including bracket and at least one isolation packet being placed in the bracket, wherein
It is equipped with air inlet in isolation packet side, the other side sets out air port, and the isolation packet is outer to be additionally provided with blower and first Imitate filter, air inlet filter fan, outlet air filter fan, total intake stack;
Wherein, the blower and primary filter were entered the wind by total intake stack connection air inlet filter fan The outlet air end of filter ventilator connects the air inlet of the isolation packet;The air outlet of the isolation packet connects outlet air filter fan, And valve is equipped on total intake stack.
Side is equipped at least one isolation packet on the bracket, and at least one isolation packet is equipped in the bracket, leads to It crosses total intake stack and connects each branch's intake stack that packet is isolated to its air inlet filter fan, and in each branch's blast pipe Road is designed with valve.
It is wrapped in the isolation and is additionally provided with delivery bin and transmitting bin bracket;Inner overcap is respectively equipped in the delivery bin two sides With outer cap sealed, inner overcap is located at the side that delivery bin leads to isolation packet, and outer nut cap is located at delivery bin and leads to extraneous side, Inner overcap is fixed by three rubber ring overlappings.
Cage is provided in isolation packet, and the corner of cage two sides fixed plate uses mellow and full smooth structure, avoids Scratch isolation packet.
It is wrapped in the isolation and is equipped with cushion between bottom and bracket.
The isolation packet is made of polyurethane film, and is sutured in the splicing of material polyurethane film using double slit, and really Guarantor can maintain reveal without obvious at least 48 hours under 1000pa pressure difference.The polyurethane film transparency is good, facilitates operation and sight Examine the activity condition that interior animal is wrapped in isolation.Polyurethane film has stronger puncture resistant and tear resistance, prevents contingency Caused by pollute.
The air inlet filter fan and outlet air filter fan are all stainless steel material, can pass through high pressure steam sterilization Mode is thoroughly sterilized, and guarantees the air cleanliness for entering isolation packet by entering the wind filter fan.
The frame bottom of the isolator is equipped with the locking structure of four-wheel.
Isolator external connection mouth not additional in addition to delivery bin and inlet and outlet.
The isolator can be dismantled easily after use and carry out the cleaning and disinfection at no dead angle.
The isolator is using 1 opening directly communicated with the outside world for only retaining the outer nut cap of delivery bin.
Isolator airtightness of the present invention is good, and sufficiently sterilizing means can be used to guarantee the sterile effect that packet internal environment is isolated Fruit.Design details improvement of the present invention surprisingly breaks ring caused by isolation packet is effectively reduced in operation or transfer;Present invention design is filled Divide and utilize space, convenient for operation, improves the efficiency of user.The present invention design can be obtained it is a kind of sterilizing sufficiently, securely and reliably, behaviour Make convenient novel practical isolator.
Isolation packet delivery bin two sides of the invention are respectively equipped with inner overcap and outer cap sealed, and inner overcap is logical positioned at delivery bin To the side of isolation packet, outer nut cap is located at delivery bin and leads to extraneous side, and inner overcap is fixed by three rubber ring overlappings, guaranteed Isolation is wrapped interior environment and is thoroughly completely cut off with external environment.Delivery bin is passed through in article disengaging, and the alternating of inside and outside nut cap is opened, outside delivery bin Nut cap increases length on traditional infrastructure, can the biggish article of receiving volume be put into delivery bin.
The internal sterile subenvironment obtained by sterilizing is had collarium border complete by sterile isolation packet using physical isolation with the external world It is complete to be isolated, and ensure to keep interior environment sterile in regular job by setting high efficiency particle air filter and isolation gloves.
Detailed description of the invention
Fig. 1 is the rearview of one embodiment of Sterilized isolator of the present invention.
Fig. 2 is the front view of one embodiment of Sterilized isolator of the present invention.
Fig. 3 is the schematic diagram that Sterilized isolator of the present invention ventilation uses.
Fig. 4 is Sterilized isolator ventilation filter schematic diagram of the present invention.
Fig. 5 A is the cage schematic diagram in the isolation packet of Sterilized isolator;Fig. 5 B is that isolation packet rearview shows cage and passes Pass bin location;Fig. 5 C is isolation packet front view cage position view.
Wherein, 10 isolation packet, 18 brackets, 19 brake casters, 1 blower and primary filter, 2 total intake stacks, 22 branches 12 valve of intake stack, 3 air inlet filter fans, 4 outlet air filter fans, 5 delivery bins, 6 transmitting bin brackets, 7 cushions, 8 Two packet cages, 9 gloves lassos, 11 cages, 13 filter fan top ducts opening, 14 filter fan inner core main bodys, 15 Filter fan inner core bottom, 16 filter fan housings, 17 filter fan housings opening.
Specific embodiment
Above scheme is described further below in conjunction with specific embodiment.It should be understood that these embodiments are for illustrating The present invention rather than limit the scope of the invention.Implementation condition used in the examples can be done according to the condition of specific producer Further adjustment, the implementation condition being not specified is usually the condition in routine experiment.
Sterilized isolator of the invention as shown in Fig.1 and Fig.2, including bracket 18 and be placed in the bracket 18 one every From packet 10, air inlet is offered in 10 sides of isolation packet, the other side is equipped with air outlet, and blower and just effect are additionally provided with outside isolation packet 10 Filter 1, air inlet filter fan 3, outlet air filter fan 4, total intake stack 2;Wherein, blower and primary filter 1 are logical The total connection of intake stack 2 air inlet filter fan 3 is crossed, the outlet air end of air inlet filter fan 3 connects air inlet;Air outlet connection Outlet air filter fan 4, and valve 12 is equipped on total intake stack 2;It is wrapped in isolation and is additionally provided with delivery bin 5 and delivery bin branch Frame 6;It is respectively equipped with inner overcap and outer cap sealed in 5 two sides of delivery bin, inner overcap is located at delivery bin 5 and leads to isolation packet 10 Side, outer nut cap is located at delivery bin 5 and leads to extraneous side, and inner overcap is fixed by three rubber rings overlappings, in the present embodiment In, it is equipped with an isolation packet 10 in bracket 8, an isolation packet 10 is additionally provided on bracket 8, is connected by total intake stack 2 The air inlet filter fan 3 of isolation packet on branch's blast pipe 22 to bracket, and valve 12 is equipped in branch's intake stack 22.
In this way, in practice, controlling air-flow opening and closing by the connection of branch's blast pipe and valve, can splicing as more as possible Isolation packet.Be equipped with cushion 7 between isolation 10 bottoms of packet and bracket 18, be effectively reduced isolation wrap in article when inadvertently falling off Caused by destroy.
The schematic diagram of Sterilized isolator ventilation behaviour in service as shown in Figure 3, passes through the connection and valve control of intake stack The blast pipe of the isolation packet of lower layer can be connected with the blast pipe of upper layer isolation packet, theoretically, can be spliced by air-flow opening and closing processed Infinite number of isolation packet.
Further, the content includes following aspect:
The Filter column of air inlet filter fan 3 and outlet air filter fan 4 as shown in Figure 4 is by inner core and 16 groups of housing At, be all made of stainless steel material production.Inner core bottom 15 is closed, and inner core main body 14 is hollow design, and body exterior package is efficient Air-filtering membrane, top are equipped with pipeline tapping 13, for connecting isolation packet air inlet or air outlet;Housing 16 is designed as pedestal and outer It is closed to cover shaft welding, housing shaft has cylinder opening 17, for connecting intake stack or direct air draft.
Fig. 5 A is the cage schematic diagram in the isolation packet of Sterilized isolator;Fig. 5 B is that isolation packet rearview shows cage and passes Pass bin location;Fig. 5 C is isolation packet front view cage position view.Shown in tetrad pouch-type fexible film isolator The design of cage fixed plate, which is used, makes full use of space close to delivery bin and operating gloves side shape for arc, and facilitates operation.
The outer nut cap of delivery bin has an opening, uses for packet air tightness test and spraying disinfection liquid to be isolated.Animal, feeding Material, drinking-water and various apparatus are entered and left by delivery bin, and two nut cap interactions are opened;Filter fan is after high pressure steam sterilization Be assembled on isolator, air enters intake stack by external blower and primary filter, by air inlet filter fan into Enter in isolation packet, guarantees the cleanliness of air in isolation packet.
Delivery bin is passed through in article disengaging, and the alternating of inside and outside nut cap is opened, and inner overcap is fixed by three rubber ring overlappings, guarantees Isolation is wrapped interior environment and is thoroughly completely cut off with external environment.The outer nut cap of delivery bin increases length on traditional infrastructure, can receiving volume compared with Big article is put into delivery bin.
Isolator design increases the foam pad of one layer of cushion, and isolation packet is outer to be laid with one layer of soft thin pad, plays buffering and makees With.
Distance increases between tetrad pouch-type fexible film isolator delivery bin and ventilation column, facilitates and sterilizes behaviour outside delivery bin Make.
The outer nut cap of the isolator delivery bin of the utility model has an opening, for packet air tightness test and spraying disinfection liquid to be isolated It uses.Animal, feed, drinking-water and various apparatus are entered and left by delivery bin, and two nut cap interactions are opened;Filter fan is through height Pressure steam sterilizing after be assembled on isolator, air enters intake stack by air blower, by air inlet filter fan into every From the cleanliness in packet, guaranteeing air in isolation packet.
The Sterilized isolator airtightness of the utility model is good, and air inlet and the outlet filter fan passes through high pressure steam sterilization mode It is assembled after sterilizing, inside uses Clidox thimerosal spraying disinfection, and sterilizing methods are simple and reliable.The present invention is isolated in tradition On the basis of device, the structure of air inlet/outlet filter fan is innovated, it is convenient to be carried out by way of high pressure steam sterilization thoroughly The hidden danger of conventional separators air inlet pollution is eliminated in sterilizing.The risk of isolator bale broken and pollution is effectively reduced in the isolator.Entirely Isolator reaches gnotobasis, accomplishes the complete isolation of germfree animal and nature microorganism.
Obviously, above-described embodiment is just for the sake of clearly demonstrating examples of the invention, and being not is to the present invention The restriction of embodiment can also make on the basis of the above description for those of ordinary skill in the art Other various forms of variations or variation here can not be exhaustive all embodiments, all to belong to skill of the invention The obvious changes or variations that art scheme is extended out are still in the scope of protection of the present invention.

Claims (9)

1. a kind of Sterilized isolator, including bracket and at least one isolation packet being placed in the bracket, which is characterized in that
It is equipped with air inlet in isolation packet side, the other side sets out air port, and the isolation packet is outer to be additionally provided with blower and just imitated Filter, air inlet filter fan, outlet air filter fan, total intake stack;
Wherein, by total intake stack connection air inlet filter fan, air inlet filtering is logical for the blower and primary filter The outlet air end of wind device connects the air inlet of the isolation packet;The air outlet connection outlet air filter fan of the isolation packet, and Total intake stack is equipped with valve.
2. Sterilized isolator according to claim 1, which is characterized in that side is equipped at least one isolation on the bracket Packet, and at least one isolation packet is equipped in the bracket, branch's blast pipe of each isolation packet is connected by total intake stack Filter fan is entered the wind to it in road, and is designed with valve in each branch's intake stack.
3. Sterilized isolator according to claim 1, which is characterized in that wrapped in the isolation and be additionally provided with delivery bin and biography Pass bin bracket;It is respectively equipped with inner overcap and outer cap sealed in the delivery bin two sides, inner overcap is located at delivery bin and leads to isolation The side of packet, outer nut cap are located at delivery bin and lead to extraneous side, and inner overcap is fixed by three rubber ring overlappings.
4. Sterilized isolator according to claim 1, which is characterized in that be provided with cage, and cage in isolation packet The corner of frame two sides fixed plate uses mellow and full smooth structure.
5. Sterilized isolator according to claim 3, which is characterized in that wrap in the isolation and be equipped between bottom and bracket Cushion.
6. Sterilized isolator according to claim 1, which is characterized in that the isolation packet is made of polyurethane film, and It is sutured in the splicing of material polyurethane film using double slit.
7. Sterilized isolator according to claim 1-6, which is characterized in that the air inlet filter fan and go out Wind filter fan is all stainless steel material.
8. Sterilized isolator according to claim 1, which is characterized in that the frame bottom of the isolator is equipped with four-wheel Locking structure.
9. Sterilized isolator according to claim 1, which is characterized in that the isolator except delivery bin and inlet and outlet with Outer not additional external connection mouth.
CN201910853274.8A 2019-09-10 2019-09-10 Sterilized isolator Pending CN110447547A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910853274.8A CN110447547A (en) 2019-09-10 2019-09-10 Sterilized isolator

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910853274.8A CN110447547A (en) 2019-09-10 2019-09-10 Sterilized isolator

Publications (1)

Publication Number Publication Date
CN110447547A true CN110447547A (en) 2019-11-15

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CN201910853274.8A Pending CN110447547A (en) 2019-09-10 2019-09-10 Sterilized isolator

Country Status (1)

Country Link
CN (1) CN110447547A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113229157A (en) * 2021-05-26 2021-08-10 深圳净拓生物科技有限公司 Aseptic animal isolator

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2441310Y (en) * 2000-09-21 2001-08-08 上海天环科技发展有限公司 Top cover type single air exchanging cage box
CN2501308Y (en) * 2001-09-17 2002-07-24 陈闻天 Single air-interchanging cage with high efficient filter
CN2824560Y (en) * 2005-10-11 2006-10-11 中国医学科学院实验动物研究所 Asepsis isolator
CN201393455Y (en) * 2009-04-20 2010-02-03 浙江省医学科学院 Aseptic isolator
CN204579435U (en) * 2015-02-13 2015-08-26 北京维通利华实验动物技术有限公司 A kind of animal for research Sterilized isolator
CN105107281A (en) * 2015-07-27 2015-12-02 汪清明 Air cleaning device employing filter screen and air vents
CN105684920A (en) * 2016-03-23 2016-06-22 山东新华医疗器械股份有限公司 Breed conservation isolator for genetic engineering mice
CN206294661U (en) * 2016-11-10 2017-07-04 浙江省医学科学院 A kind of Sterilized isolator for raising high-grade experimental animal
CN207574254U (en) * 2017-11-16 2018-07-06 吴江振达净化工程有限公司 A kind of animal raising box
CN207678573U (en) * 2017-11-02 2018-08-03 深圳市前海金卓生物技术有限公司 Isolating device
CN207733403U (en) * 2017-12-19 2018-08-17 广东药科大学 A kind of small-size multifunction isolating device for preventing infection of experimental animal
CN210641875U (en) * 2019-09-10 2020-06-02 赛业(苏州)生物科技有限公司 Sterile isolator

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2441310Y (en) * 2000-09-21 2001-08-08 上海天环科技发展有限公司 Top cover type single air exchanging cage box
CN2501308Y (en) * 2001-09-17 2002-07-24 陈闻天 Single air-interchanging cage with high efficient filter
CN2824560Y (en) * 2005-10-11 2006-10-11 中国医学科学院实验动物研究所 Asepsis isolator
CN201393455Y (en) * 2009-04-20 2010-02-03 浙江省医学科学院 Aseptic isolator
CN204579435U (en) * 2015-02-13 2015-08-26 北京维通利华实验动物技术有限公司 A kind of animal for research Sterilized isolator
CN105107281A (en) * 2015-07-27 2015-12-02 汪清明 Air cleaning device employing filter screen and air vents
CN105684920A (en) * 2016-03-23 2016-06-22 山东新华医疗器械股份有限公司 Breed conservation isolator for genetic engineering mice
CN206294661U (en) * 2016-11-10 2017-07-04 浙江省医学科学院 A kind of Sterilized isolator for raising high-grade experimental animal
CN207678573U (en) * 2017-11-02 2018-08-03 深圳市前海金卓生物技术有限公司 Isolating device
CN207574254U (en) * 2017-11-16 2018-07-06 吴江振达净化工程有限公司 A kind of animal raising box
CN207733403U (en) * 2017-12-19 2018-08-17 广东药科大学 A kind of small-size multifunction isolating device for preventing infection of experimental animal
CN210641875U (en) * 2019-09-10 2020-06-02 赛业(苏州)生物科技有限公司 Sterile isolator

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113229157A (en) * 2021-05-26 2021-08-10 深圳净拓生物科技有限公司 Aseptic animal isolator
CN113229157B (en) * 2021-05-26 2022-06-28 深圳净拓生物科技有限公司 Aseptic animal isolator

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Effective date of registration: 20230117

Address after: 215400 No. 69, Zhenxi Road, Shaxi Town, Taicang City, Suzhou City, Jiangsu Province

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