CN110404596A - A kind of detection device - Google Patents
A kind of detection device Download PDFInfo
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- CN110404596A CN110404596A CN201910689936.2A CN201910689936A CN110404596A CN 110404596 A CN110404596 A CN 110404596A CN 201910689936 A CN201910689936 A CN 201910689936A CN 110404596 A CN110404596 A CN 110404596A
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- 238000001514 detection method Methods 0.000 title claims abstract description 87
- 239000007788 liquid Substances 0.000 claims description 136
- 238000007789 sealing Methods 0.000 claims description 27
- 238000012790 confirmation Methods 0.000 claims description 5
- 238000012360 testing method Methods 0.000 abstract description 18
- 238000000034 method Methods 0.000 abstract description 9
- 239000000523 sample Substances 0.000 description 127
- 238000010586 diagram Methods 0.000 description 15
- 238000005192 partition Methods 0.000 description 15
- 210000002700 urine Anatomy 0.000 description 11
- 238000000926 separation method Methods 0.000 description 7
- 238000007689 inspection Methods 0.000 description 6
- 239000002117 illicit drug Substances 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 208000002925 dental caries Diseases 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000002360 explosive Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010013654 Drug abuse Diseases 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- Urology & Nephrology (AREA)
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- Immunology (AREA)
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- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a kind of detection devices, including the first chamber for collection and for the second chamber of detection, described second is intracavitary equipped with detecting element, it can be closed and be connected between first chamber and the second chamber, it further include the third chamber quantitative for sample, sample quantitatively can be transferred to the second chamber from the first chamber by third chamber.Detection device of the invention can collect the sample for secondary detection while collecting detection sample, simple and quick, moreover, detection device of the invention can quantitatively collect sample, carry out accurate quantitative detection, testing result is true and reliable, and accuracy is higher；The application method of detection device of the present invention is simple, and operation is easy.
Description
Technical field
The present invention relates to detection devices, more particularly to the device that can be detected and be collected.
Background technique
Currently, for detect in sample whether the detection device containing analyte, be largely used to hospital or family
In, these detection devices for being applied to quick diagnosis include one or more detection reagent items, for example early pregnancy detects, drug abuse
Detection etc..The detection device of this quick diagnosis is very convenient, can be at one minute, or at most ten minutes or so are detecting
Testing result is obtained on reagent strip.
Illicit drugs inspection is widely used, be usually used in prohibition of drug department, public security bureau, narcotic house, medical center, country conscription physical examination at
Etc. mechanisms.Illicit drugs inspection wide variety, number is frequent, can be automatically separated the illicit drugs inspection urine cup of remaining sample Yu detected sample
With the huge market demand, after detection is completed, sample in urine cup will be by for illicit drugs inspection urine cup currently on the market
To detection reagent pollution and cannot continue on for second of confirmation detection, such as United States Patent (USP) 7300633 describe as.
The acquisition of big duration set exists in the prior art and is detected on integrated disposable detection device, such as Chinese patent
2008103055231 descriptions, including cup body (being equivalent to collecting chamber), the side of cup body is equipped with the test board (phase containing test paper
When in test chamber), cup body can be connected to the region where test board, such as the 0005th segment description of specification of this document, by
Urine is placed in urine cup by testing staff, and the intercommunicating pore on the liquid outlet and cup body on positioning element control test board at this time is not
Connection, when personnel to be detected detect, testing staff adjusts positioning element, by liquid outlet and intercommunicating pore connection, simultaneously
Cup body is inverted, urine flows into test-strips cavity, autonomous starting reaction.When after reaction, interpretation simultaneously records as a result, will
Urine cup is just set, and the separation of the urine in the urine and urine cup in detection zone is realized.In this manner, urine is controlled
The amount for flowing into detection zone, needs testing staff according to itself experience and work habit to operate, and can not determine into detection
Region carries out running on the test strip the amount of the liquid sample of plate, however, the control of the amount of sample is past during Precision measurement
Have a great impact toward meeting to testing result.
It for these above-mentioned technical problems, therefore needs to make improvements, other approach is provided and solves existing traditional skill
The deficiency of art.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of detection devices, can either carry out the acquisition of liquid sample,
Detection and secondary collection, and can be realized accurate quantitative detection.
The technical proposal adopted by the invention to solve the above technical problems is that:
A kind of detection device, including the first chamber for collection and for the second chamber of detection, described second intracavitary is equipped with
Detecting element can be closed and is connected between the first chamber and the second chamber, further include the third chamber quantitative for sample, third chamber
Sample quantitatively can be transferred to the second chamber from the first chamber.In some preferred modes, third chamber can be received in the first chamber
Liquid sample is obtained while collection, third chamber can also obtain liquid after the first chamber is collected in some preferred modes
Sample.
Further, the first chamber is equipped with the opening that can be connected to third chamber.In some preferred modes, the first chamber
Side is equipped with opening, which can be connected to third chamber, and in some preferred modes, which can be closed.One
In a little preferred modes, third chamber, which is equipped with, is connected to oral area with the first chamber, in some preferred modes, the oral area range of third chamber
At least it is not less than the opening range of the first chamber, in some preferred modes, when the oral area of third chamber and the opening weight of the first chamber
It closes or partially overlaps, can allow for liquid sample when passing through from this overlapping position, it is believed that the first chamber and third chamber connect
It is logical.
Further, third chamber can be connected to the first chamber or the second chamber respectively.In some preferred modes, third chamber
It can be preferentially connected to the first chamber, after sample after the intracavitary completion of third is quantitative, third chamber and the first chamber separate, then third chamber
It is connected to again with the second chamber, carries out the quantitative detection of sample.In some preferred modes, third chamber and the first chamber connection when
It waits, be in partition state with the second chamber, in some preferred modes, when third chamber and the connection of the second chamber, with the
One chamber is in partition state.
Further, third chamber is equipped with sealing structure.In some preferred modes, the oral area of third chamber is equipped with sealing knot
Structure, in some preferred modes, sealing structure plays the role of sealing third accent portion, prevent when third chamber is closed
The into and out third chamber of liquid sample, in some preferred modes, when third chamber and the connection of the first chamber or the second chamber,
Sealing structure plays the role of sealing in connectivity part or opening, prevents liquid sample from flowing to other than the first chamber and third chamber
Place.
Further, the third chamber includes at least one liquid relief for being used to for sample being transferred to the second chamber from the first chamber
Area.In some preferred modes, third chamber can have one, two or more liquid relief areas, these liquid relief areas can be real
Existing sample quantifies, and in some preferred modes, these liquid relief areas can be connected to the first chamber respectively, in some preferred sides
In formula, these liquid relief areas each can independent liquid storage, in some preferred modes, the liquid storage amount in these liquid relief areas can phase
Same or different, in some preferred modes, these liquid relief areas can be successively respectively communicated with the first chamber or the second chamber, thus
Compartment of terrain carries out quantitative detection.In some preferred modes, adjacent liquid relief area can be joined seamlessly to next liquid relief area, keep away
There is the phenomenon of leakage between area in Mian Liangge liquid relief.
Further, the detecting element can be in the second intracavitary movement.In some preferred modes, second it is intracavitary can
To accommodate detecting element and sample, in some preferred modes, under certain condition, the detecting element sample that can get along well is connect
Touching, when conditions are changing, detecting element can be just in contact with sample, in some preferred modes, the movement of detecting element
It can lead to the separation or contact of detecting element and sample.
Further, the third chamber can be mobile with detecting element, to be connected to respectively with the first chamber or the second chamber.In
In some preferred modes, the movement of detecting element can drive third chamber and the first chamber to be connected to or separate, some preferred
In mode, the movement of detecting element can drive third chamber and the second chamber to be connected to or separate.
Further, including linkage element, the linkage element are able to drive the detecting element movement.Some preferred
Mode in, the movement of detecting element is realized under external force, and in some preferred modes, linkage element can be with
The other component of detection device links, to drive detecting element mobile, in some preferred modes, linkage element be can be
Other component in detection device, such as lid.
Further, the described second intracavitary channel for being equipped with the sample that can allow for third intracavitary and entering.Some preferred
Mode in, this channel can be set between the first chamber and the second chamber, in some preferred modes, the first chamber and second
Chamber has a common wall surface, and in some preferred modes, third chamber can slide on this common wall surface, at this
A resigning breach can be set on a wall surface, when third chamber is moved to resigning breach, wherein the liquid sample stored will
It is intracavitary to flow into second.In some preferred modes, this common wall surface has certain gradient, in some preferred modes
In, when third chamber moves on this wall surface, Open Side Down, flows out convenient for liquid sample.
It further, further include the 4th chamber that sample is detected for collecting secondary-confirmation, the 4th chamber can connect with the first chamber
Logical or partition.In some preferred modes, linkage element can link the connection or partition of the 4th chamber and the first chamber simultaneously, example
Such as, when linkage element drives detecting element mobile, it can be connected to the 4th chamber and the first chamber simultaneously.In some preferred modes
In, the first chamber is equipped with the opening that can be connected to the 4th chamber.In some preferred modes, the 4th chamber can be with the first chamber simultaneously
Carry out the collection of sample.
Further, further include separating element for being connected to or separating the first chamber and the 4th chamber.
Further, including linkage element, the linkage element can be linked with the separating element so that separating
Element connection or the first chamber of partition and the 4th chamber.In some preferred modes, separating element can by linkage element link from
And it is connected to or separates the first chamber and the 4th chamber.In some preferred modes, linkage element can link separating element simultaneously
And detecting element.
Further, when the separating element separates first chamber and four chambers, the first chamber can be from the 4th chamber quilt
Separation.In some preferred modes, the first chamber is equipped with the channel for leading to the 4th chamber, in some preferred modes, the 4th chamber
It is equipped with opening, in some preferred modes, the 4th chamber and the first chamber are removably combined, in some preferred modes,
4th chamber can be separated from the first chamber, and in some preferred modes, the closure member of the 4th chamber can also be arranged, when
After four chambers and the separation of the first chamber, the 4th chamber can be closed, referred to as a closed individual cavity, so that storage is for secondary
The liquid sample of detection.
Further, the linkage element includes lid, the cover cap can link when closing the detecting element and/or
The separating element.In some preferred modes, it can close up with cup body downwards when cover cap closes, lid is same what is moved down
When, detecting element can be pushed, to make detecting element in the second intracavitary movement.
Further, there is certain angle between the detecting element and the bottom of the detection device.
The beneficial effects of the present invention are:
(1) detection device of the invention can collect the sample for secondary detection while collecting detection sample, letter
It is single quick；Detection device of the invention can quantitatively collect sample, carry out accurate quantitative detection, and testing result really may be used
It leans on, accuracy is higher；And the application method of detection device of the present invention is simple, and operation is easy.
Detailed description of the invention
Fig. 1 is the explosive view (wherein, the second chamber is in left side) of apparatus of the present invention.
Fig. 2 is the explosive view that apparatus of the present invention are in another state (wherein, the second chamber is on right side).
Fig. 3 is the structural schematic diagram that device assembles in Fig. 2.
Fig. 4 is the structural schematic diagram of separating element.
Fig. 5 is the structural schematic diagram of the first bottle cap.
Fig. 6 is the structural schematic diagram that the first bottle cap and lid are in discrete state.
The structural schematic diagram that the lid and the first connector that Fig. 7 is link together.
The first connector and separating element that Fig. 8 is are in the structural schematic diagram of discrete state.
Fig. 9 is the structural schematic diagram (in figure, in order to show the structure in the second bottom of chamber portion, having concealed collet) of cup body.
Figure 10 is the structural schematic diagram after Fig. 9 is splitted.
Figure 11 is the structural schematic diagram of inserted sheet.
Figure 12 is the front view of inserted sheet.
Figure 13 is the structural schematic diagram in liquid relief area.
Figure 14 is the structural schematic diagram that apparatus of the present invention are in original state.
Figure 15 is the cross-sectional view of Figure 14.
Figure 16 be lid in the open state, the structural schematic diagram of apparatus of the present invention.
Figure 17 is the cross-sectional view (having concealed lid) of Figure 16.
Figure 18 is the cross-sectional view of apparatus of the present invention during cover cap closes cup body.
When Figure 19 is that lid covers conjunction cup body completely, the structural schematic diagram of apparatus of the present invention.
Figure 20 is the cross-sectional view of Figure 19.
After the completion of Figure 21 is pattern detection, the first bottle cap and lid are in discrete state, while at the 4th chamber and the first chamber
In the structural schematic diagram of discrete state.
Figure 22 is the structural schematic diagram that the 4th cavity is in closed state.
Specific embodiment
A specific embodiment of the invention is described in further details below in conjunction with attached drawing, it is noted that implement
Example is only specifically described of the invention, is not construed as limitation of the invention.
Specific embodiment, referring to attached drawing 1-22.
As shown in Figure 1-3, the present invention provides a kind of detection device, including the first chamber 1 for collection and for detection
Second chamber can be closed and be connected between the first chamber 1 and the second chamber, further include the third chamber quantitative for sample, third chamber
Sample quantitatively can be transferred to the second chamber from the first chamber 1.As shown in Figure 1-3, detection device includes lid in the present embodiment
With cup body, cup body includes the first chamber 1, the second chamber and third chamber, and lid 7, which can cover, closes the first chamber 1, and lid 7 passes through with the first chamber 1
It is threadedly coupled, in other embodiments, lid 7 and the first chamber 1 are also possible to clamping connection or using other connection types
It is attached；In some preferred modes, the first chamber 1, the second chamber can be connected between any two with third chamber, when two cavitys
When connection, transfer of the liquid sample between two cavitys may be implemented；Third chamber can shift a certain amount of liquid sample
To the second chamber；In the present embodiment, the second chamber and third chamber are convenient for third chamber by liquid sample in this way in the same side of the first chamber 1
It is transferred in the second chamber.
In some preferred modes, as shown in Figure 1-3, the second chamber includes the second cavity 2 and collet 20, collet 20 can be with
Receive the liquid sample that third chamber or the first chamber are transferred to the second chamber, in the present embodiment, collet 20 and the second cavity 2 pass through weldering
It connects and is attached, in other preferred modes, collet 20 can also be attached by other means with the second cavity 2,
For example, bonding etc., the second cavity 2 is fixedly connected as after an entirety with collet 20, and there is no the phenomenon of leakage, some excellent
In the mode of choosing, the second cavity 2 is obliquely installed, and collet 20 is also obliquely installed, collet 20 and the inclined angle one of the second cavity 2
It causes, still, the bottom surface of collet 20 is horizontal plane, and collet 20 can be positioned horizontally on horizontal plane, so that device is more
Stablize, is conducive to the progress of detection；In some preferred modes, the angle of the second cavity 2 and horizontal plane is greater than 0οIt is less than
90ο, be conducive to third chamber in this way for liquid sample and be transferred to the second chamber.
In some preferred modes, as shown in Figure 1-3, second is intracavitary equipped with inserted sheet 21, inserted sheet 21 includes plate 211,
211 the top of plate is fixedly connected with the first support chip 212, and in some preferred modes, 212 upper surface of the first support chip is solid
Surely it is connected with bolt 23；In some preferred modes, as shown in figure 15, plate 211 is close to the side wall setting of the second cavity 2,
The tilt angle of plate 211 is consistent with the tilt angle of the second cavity 2, and in some preferred modes, the second chamber upper surface is set
There is jack 22, bolt 23 is inserted into jack 22, and stretches out jack 22, exposes 23 head of bolt；Bolt 23 is inserted into jack 22, inserts
Piece 21 is installed in the second intracavitary portion, as shown in figure 3, when pressing down on bolt 23, inserted sheet 21 can be moved down.
In some preferred modes, as depicted in figs. 11-12,211 side wall of plate is equipped at least one detecting element and puts
Area 24 is set, for placing detecting element, multiple detecting element rest areas 24 can place the inspection for detecting same or different substance
Element is surveyed, may be implemented to detect one or more kinds of substances simultaneously；In some preferred modes, multiple detecting element rest areas
Partition arm 25 is equipped between 24, each detecting element is spaced, is independent of each other；In some preferred modes, detecting element
Rest area 24 is equipped with convex block, and convex block can make detecting element be in fixed position, guarantee the smooth of detection with fixed test element
It carries out, so that testing result is more accurate, reliable, when the setting of convex block can be to avoid detection, the feelings such as detecting element is shifted, fallen down
Condition occurs, and in some preferred modes, convex block includes the first convex block 26 and the second convex block 27, the first convex block 26 and the second convex block
27 cooperate, so that keep detecting element more stable.In some preferred modes, 24 lower part of detecting element rest area
Be additionally provided with flow-guiding channel 28, flow-guiding channel 28 can guide liquid sample to contact detecting element, avoid liquid sample in large quantities with
Detecting element contact, influences the accuracy of testing result.In some preferred modes, the detecting element is parallel to the second chamber
The lateral wall of body 2, detecting element are also to be obliquely installed, and detecting element is consistent with the inclined angle of the second cavity 2, then, detection
Shape is at a certain angle between element and the bottom of the detection device；Compared with detecting element is perpendicular to horizontal plane setting, inspection
It surveys element and is in heeling condition, liquid sample is enabled more to be rapidly introduced into detecting element, and on detecting element quickly
It completes to run plate detection.
In some preferred modes, as shown in Figs. 1-2, third chamber is arranged in the second intracavitary portion, in some preferred sides
In formula, third chamber is arranged on plate 211, and in some preferred modes, third chamber is arranged on plate 211 detecting element and puts
Set the back side in area, so that third chamber can be moved with the movement of inserted sheet 21.
Further, the first chamber 1 is equipped with the opening 4 that can be connected to third chamber, and liquid sample can be open 4 by the from this
One chamber enters third chamber, realizes the transfer of liquid sample；In some preferred modes, third chamber can be collected in the first chamber 1
While liquid sample, liquid sample is obtained from opening 4, third chamber can also be received in the first chamber 1 in some preferred modes
After collection, then from opening 4 obtain liquid sample.
In some preferred modes, as shown in Figure 15,17,18, the side wall of the first chamber 1, the opening 4 is arranged in opening 4
It can be connected to third chamber, after third chamber is connected to opening 4, liquid sample can be transferred to third chamber from the first chamber；Some
In preferred mode, which can be closed, and in some preferred modes, third chamber is equipped with the mouth being connected to the first chamber 1
Portion, in some preferred modes, the oral area range of third chamber is at least not less than 4 range of opening of the first chamber 1, when opening 4 is complete
After portion is overlapped with oral area, liquid sample all enters third chamber by oral area by 4 outflow of opening, if oral area range is less than opening
4 ranges, then, liquid sample enters third chamber by oral area by 4 outflow of opening, only part, meanwhile, other liquid samples will flow
To elsewhere, liquid sample is wasted, and is possible to enter third chamber via oral area by 4 outflow of opening in liquid sample
Meanwhile having partially liq sample that can flow into the second chamber, it will lead to the amount that can not determine the liquid into the second chamber, Wu Fashi in this way
Plate is now quantitatively run, testing result is influenced.In some preferred modes, when the oral area of third chamber and the opening 4 of the first chamber 1 are overlapped
Or partially overlap, it can allow for liquid sample when passing through from this overlapping position, it is believed that the first chamber 1 and third chamber connect
It is logical.
Further, third chamber can be connected to the first chamber 1 or the second chamber respectively；As shown in Figure 15,17,18, third chamber
And first when being connected between chamber 1, liquid sample can enter third chamber, as shown in figure 20, third chamber and the second chamber by the first chamber 1
Between when being connected to, liquid sample can enter the second chamber by third chamber, and the transfer of liquid sample may be implemented in this way.Some excellent
In the mode of choosing, third chamber can be preferentially connected to the first chamber 1, after sample third it is intracavitary complete it is quantitative after, third chamber and the
The partition of one chamber 1, then third chamber is connected to the second chamber again, carries out the quantitative detection of sample.In some preferred modes, third
When connection between chamber and the first chamber 1, partition state is between third chamber and the second chamber, as shown in Figure 15,17,18, this
Sample can guarantee, when liquid sample enters third chamber in the first chamber 1, the liquid sample of third chamber will not enter the second chamber, that
, after being connected between third chamber and the second chamber, the volume into the liquid sample of the second chamber be it is certain, may be implemented quantitative
The purpose of detection；If the liquid sample of third chamber enters the simultaneously when liquid sample enters third chamber in the first chamber 1
Two chambers, then, finally, it is uncertain for entering the volume of the liquid sample of the second chamber, therefore, it is impossible to realize intracavitary second
Carry out quantitative detection.In some preferred modes, when connection between third chamber and the second chamber, third chamber and the first chamber 1
Between can guarantee so as shown in figure 20 in partition state, when liquid sample enters the second chamber in third chamber, the first chamber 1
Liquid sample will not enter the third chamber, (in the case where having multiple third chambers in the embodiment having, third here
Chamber refers to the same third chamber), then, after being connected between third chamber and the second chamber, into the liquid sample of the second chamber
Volume be it is certain, the purpose of quantitative detection may be implemented；If when liquid sample entered the second chamber in third chamber, first
The liquid sample of chamber 1 enter simultaneously the third chamber (in the case where having multiple third chambers in the embodiment having, here the
Three chambers refer to the same third chamber), then, finally, enter the liquid sample of the second chamber volume be it is uncertain, because
This, cannot achieve in the second intracavitary carry out quantitative detection.
Further, as shown in Figs. 1-2, third chamber is equipped with sealing structure 30, and as shown in figure 13, the boundary of third chamber is set
Fluted, sealing structure can be stuck in groove, play the role of sealing；In the present embodiment, sealing is selected to be carried out with flexible glue
Sealing, sealing is assembled in the groove of third chamber boundary with flexible glue；The setting of sealing structure 30 can guarantee to enter third
Liquid sample in chamber will not be missed, if constantly missed into the liquid sample in third chamber, into the second chamber, then,
Third chamber is possible to just store the liquid sample that cannot store determining volume less than liquid sample or third chamber, and enters
The volume of liquid sample in second chamber be also it is uncertain, do not have thus it is quantitative race plate detection effect；Some excellent
In the mode of choosing, the oral area of third chamber is equipped with sealing structure 30, and such sealing effect is preferable, close in some preferred modes
Seal structure 30 plays the role of sealing third accent portion, prevents the into and out third of liquid sample when third chamber is closed
Chamber can guarantee that third chamber can store the liquid sample of certain volume in this way, convenient for quantitatively running plate, in some preferred modes
In, when third chamber and the connection of the first chamber 1 or the second chamber, sealing structure 30 plays the work of sealing in connectivity part or opening
With, prevent liquid sample from flowing to the place other than the second chamber and third chamber, can make in this way third chamber and the first chamber 1 it
Between when being connected to, liquid sample can flow to third chamber in the first chamber 1, may not flow into the place other than third chamber, can mention in this way
High efficiency makes third chamber store a certain amount of liquid sample quickly；When being connected between third chamber and the second chamber, can be made
Liquid sample all flow to the second chamber in three chambers, and then can quantify, and may not flow into the place other than the second chamber.
Further, the third chamber includes at least one liquid relief for being used to for sample being transferred to the second chamber from the first chamber 1
Area 6, in some preferred modes, third chamber can have one, two or more liquid relief areas 6, these liquid relief areas 6 can
The quantitative transfer of sample is realized, as shown in Fig. 2, liquid relief area 6 is two in the present embodiment.In some preferred modes, these
Liquid relief area 6 can be connected to the first chamber 1 respectively, so that liquid relief area 6 can obtain liquid sample from the first chamber respectively, carry out
Quantitative storage；In some preferred modes, these liquid relief areas 6 each can independent liquid storage, do not influence between each other, one
In a little preferred modes, the liquid storage amount in these liquid relief areas 6 can be same or different, as shown in Fig. 2,13, in the present embodiment, moves
The liquid storage amount of liquid zone 6 is identical.In some preferred modes, these liquid relief areas 6 can successively distinguish with the first chamber 1 or the second chamber
Connection, these liquid relief areas 6 are successively connected to the first chamber 1, may be implemented for the liquid sample in the first chamber 1 to be successively transferred to multiple
Liquid relief area, these liquid relief areas 6 can be successively connected to the second chamber, and multiple liquid relief areas may be implemented in this way and be successively quantitatively transferred to
Two chambers.In some preferred modes, as shown in Figure 15,17,18, adjacent liquid relief area 6 can be joined seamlessly to next liquid relief
Area 6 avoids the phenomenon of leakage occur between Liang Ge liquid relief area 6.
Further, the detecting element can be in the second intracavitary movement.In some preferred modes, as shown in Figure 1,
Second it is intracavitary can accommodate detecting element and sample, detecting element is placed on the detecting element rest area 24 on inserted sheet 21, sample
It is concentrated mainly in the bottom of the second chamber, some samples carry out running plate detection on detecting element；In some preferred modes,
Under certain condition, detecting element can get along well sample contact, and when conditions are changing, detecting element can just connect with sample
Touching, for example, at the beginning, as shown in figure 15, being connected between third chamber and the first chamber 1, the liquid sample in the first chamber 1 enters third
Chamber, will not get along well sample contact into the second chamber, detecting element, when conditions are changing, as shown in figure 20, the liquid in third chamber
Sample enters the bottom of the second chamber, and the liquid sample in the second bottom of chamber portion is contacted with detecting element by flow-guiding channel 28, examined
It surveys；In some preferred modes, the movement of detecting element can lead to the separation or contact of detecting element and sample；Detection member
Part can be moved with inserted sheet 21, as shown in figure 17, at this point, liquid sample, in third chamber, liquid sample does not enter into
Two chambers do not have liquid sample in the second chamber, and therefore, detecting element and liquid sample are separation, and inserted sheet 21 constantly moves down,
Liquid sample in third chamber constantly enters the bottom of the second chamber, and the liquid sample in the second bottom of chamber portion can pass through flow-guiding channel 28
It is contacted with detecting element.
Further, the third chamber can be mobile with detecting element, thus be connected to respectively with the first chamber 1 or the second chamber,
As shown in Figure 1, the back side of the detecting element rest area 24 of inserted sheet 21 is arranged in third chamber, inserted sheet 21 is constantly moved down, detection
Element also constantly moves down, and third chamber is also constantly moving down, and liquid storage zone position is also moved down, and third chamber is first with
The connection of one chamber 1, as shown in figure 15；In continuous folding process, third chamber can be connected to the second chamber, as shown in figure 20.Some excellent
In the mode of choosing, the movement of detecting element can drive third chamber and the first chamber to be connected to or partition, with the movement of detecting element,
Third chamber constantly moves, as shown in figure 15, at this point, third chamber and the connection of the first chamber；As shown in figure 20, at this point, the one of third chamber
A liquid relief area 6 and the partition of the first chamber；In some preferred modes, the movement of detecting element can drive third chamber and the second chamber
Connection or partition；As shown in Figure 17,18, at this point, third chamber and the second chamber are separated, with the movement of detecting element, third chamber
It is constantly mobile, as shown in figure 20, at this point, a liquid relief area 6 of third chamber is connected to the second chamber.
Further, which further includes linkage element, and the linkage element is able to drive the detecting element and moves
It is dynamic.In some preferred modes, the movement of detecting element is realized under external force, in some preferred modes,
Linkage element can link with the other component of detection device, thus drive detecting element mobile, in some preferred modes,
Linkage element can be the other component in detection device, such as lid 7.As shown in Fig. 3,14,15,18, in the present embodiment, connection
Dynamic element is lid 7, rotates lid 7, moves down lid 7, and lid 7 is contacted with the bolt 23 on inserted sheet 21, then, is continued
Lid 7 is rotated, inserted sheet 21 is under pressure, and moves down, so that detecting element is mobile.
Further, the described second intracavitary channel for being equipped with the sample that can allow for third intracavitary and entering, some preferred
Mode in, this channel can be set between the first chamber 1 and the second chamber, in some preferred modes, the first chamber 1 and
Two chambers have a common wall surface 9, as shown in Figure 10,15；In some preferred modes, third chamber can be common at this
Wall surface 9 on slide, a resigning breach 8 can be set on this wall surface 9, as shown in Figure 10, allowed when third chamber is moved to
When the notch 8 of position, wherein will to flow into second intracavitary for the liquid sample stored.In some preferred modes, this common wall
Face 9 has certain gradient, and in some preferred modes, the tilt angle of this common wall surface 9 and the second cavity 2 are tilted
Angle it is consistent, in some preferred modes, when third chamber moves on this wall surface 9, the oral area of third chamber is downward, just
It is flowed out in liquid sample.
Further, the detection device further include for collect secondary-confirmation detection sample the 4th chamber 10, as Fig. 1-3,
Shown in 14-22, the 4th chamber 10 can be connected to or separate with the first chamber 1, in some preferred modes, the 4th chamber 10 and the first chamber
1 dismountable combination, the 4th chamber 10 can be connected or are threadedly coupled by clamping with the first chamber 1, in other preferred sides
In formula, the 4th chamber 10 can also be connect by other means with the first chamber 1；In some preferred modes, as shown in figs. 9-10,
First chamber 1 has the first interface channel 31, and the first chamber 1 is connect by the first interface channel 31 with the 4th chamber 10, and the first connection is logical
Road 31 protrudes from the bottom surface of the first chamber, and the first interface channel 31 is columnar channel；As shown in figure 21, the 4th chamber 10 has convex
The second interface channel 32 out, the second interface channel 32 are also columnar channel, and the diameter of the second interface channel 32 is greater than the
The diameter of a connection channel 31, then, the second interface channel 32 can cover in 31 outside of the first interface channel, so that first
Liquid sample in interface channel 31 can be completely into the second interface channel 32, and then flows into the 4th chamber, will not make liquid
Sample leaks out, and flows in addition to the second interface channel 32 elsewhere；As shown in Figure 16,17, the first interface channel 31 and
Two interface channels 32 connection, at this point, the 4th chamber 10 and the first chamber 1 are in connected state；If filled in the first interface channel 31
Enter a plug or other interruptions, then, the 4th chamber 10 and the first chamber 1 are just separated.In some preferred modes,
4th chamber 10 is connected to by the collection that the 4th chamber 10 can carry out sample with the first chamber 1 simultaneously as shown in Figure 16,17 with the first chamber 1
Afterwards, liquid sample is added into the first chamber 1, then, liquid sample can enter the 4th chamber, the 4th chamber 10 and the first chamber by the first chamber
1 can carry out the collection of sample simultaneously.
Further, as shown in Figs. 1-2, which further includes for being connected to or separating the first chamber 1 and the 4th chamber 10
Separating element, in some preferred modes, as shown in figure 4, separating element include the second connector 61 and head, second connect
Fitting 61 and head are integrally formed, in some preferred modes, as shown in figure 8, the second connector 61 of separating element can
It is connected and fixed with the first connector 33, in some preferred modes, the first connector 33 is fixedly connected with lid 7, can be
It is integrally formed, in some preferred modes, the first connector 33 is cylindrical shape, first one end of connector 33 far from lid 7
Equipped with cylinder opening, in some preferred modes, the second connector 61 is cylindrical shape, the second connector 61 and the first connector
33 connections, can be clamping connection or threaded connection or other connection types are attached, as shown in figure 8, the present embodiment
In, the cylinder opening of the first connector can be inserted in the second connector, realizes connection.
In some preferred modes, the head of separating element has a tip 35, and the head of separating element can be into
Enter the first interface channel 31, and then the first chamber 1 and the 4th chamber 10 can be separated, when the head of separating element is logical from the first connection
It is extracted in road 31, the first chamber 1 can be connected to the 4th chamber 10.In some preferred modes, as shown in Fig. 1,2,4,8, partition
The head of element 80 is equipped with the first protrusion 36 and the second protrusion 361, and in some preferred modes, first raised 36 and second is convex
It plays 361 to be arranged in parallel, the first raised 36 and second protrusion 361 is arranged at the periphery on 80 head of separating element, some preferred
Mode in, sealing ring is set between protrusion 361 in the first protrusion 36 and second, the first protrusion 36 can prevent on sealing ring
It moves, the second protrusion 361 can prevent sealing ring from moving down；In some preferred modes, sealing ring can be one or more,
Sealing ring can play the role of sealing, can thoroughly separate the first chamber 1 and the 4th chamber 10, avoid liquid sample from connection gap
Middle outflow.
In some preferred modes, as shown in Fig. 4,8, the head of separating element is set there are two the second aperture 37, and two
Second aperture 37 is oppositely arranged, and the two can be connected to, and in some preferred modes, the second aperture 37 is located under sealing ring 36
Side, the top position at tip 35；In some preferred modes, as shown in Fig. 4,8, the head of separating element has a cavity, and two
A second aperture 37 can be connected to cavity, and liquid sample can enter cavity from the second aperture 37, this cavity can keep in one
Determine the liquid sample of volume, in this way, if being already filled with liquid sample in the 4th chamber, and separating element is in the linkage of linkage element
Under, separating element constantly moves down, and when constantly entering four chambers 10, separating element will will receive resistance, at this point, the liquid in the 4th chamber
Body sample can enter cavity by the second aperture 37, and the resistance for being subject to separating element reduces, and not influence separating element continuation
Into the 4th chamber, when separating element is completely into the 4th chamber, sealing ring 36 can separate the connection of the first chamber and the 4th chamber completely,
At this point it is possible to which the 4th chamber is separated from the first chamber.
Further, the linkage element can link with the separating element so that separating element is connected to or separates
First chamber 1 and the 4th chamber 10；As shown in figure 8, linkage element is lid 7 in the present embodiment, the first connector 33 and lid 7 are solid
Fixed connection, separating element are connected and fixed with the first connector 33, and therefore, linkage element is mobile, then, separating element will be therewith
Mobile, when constantly rotating, tightening lid 7, separating element will be moved down constantly, until entering the first interface channel 31, such as be schemed
Shown in 20, at this point, the first chamber 1 and the 4th chamber 10 are in partition state, when constantly rotating, unscrewing lid 7, separating element will
It constantly moves up, separating element can be detached from the first interface channel 31, and the first chamber 1 and the 4th chamber 10 can be made to be in connected state
State.In some preferred modes, separating element can be linked to be connected to or separate the first chamber 1 and the 4th by linkage element
Chamber 10.In some preferred modes, linkage element can link separating element and detecting element simultaneously；As shown in Figs. 1-2, originally
In embodiment, linkage element is lid 7, and separating element is connected and fixed with lid 7, and separating element can be moved with the movement of lid 7
It is dynamic；Detecting element is located on inserted sheet 21, and bolt 23 is inserted into jack 22, and stretches out jack 22, and lid 7 is located at the top of jack 22,
When constantly rotating, tightening lid 7, separating element will be moved down constantly, pressure of the bolt 23 by lid 7, so that inserted sheet 21
It constantly moves down, detecting element just constantly moves down, separating element and detecting element so linkage element can link simultaneously.
Further, when the separating element separates first chamber 1 and four chambers 10, the first chamber 1 can be from the 4th
Chamber 10 is separated, and in some preferred modes, the 4th chamber 10 can be separated from the first chamber 1, as shown in figure 21, partition member
Part has separated the first chamber 1 and the 4th chamber 10, at this point it is possible to which the 4th chamber is downwardly drawn out, realizes point of the 4th chamber 10 and the first chamber 1
From.In some preferred modes, the closure member of the 4th chamber 10 can also be set, when 1 separation of the 4th chamber 10 and the first chamber
Afterwards, the 4th chamber 10 can be closed, referred to as a closed individual cavity, so that storage is used for the liquid sample of secondary detection,
As shown in Fig. 6,21,22, closure member is the first bottle cap 12, and the first bottle cap 12, which can cover, closes the 4th chamber 10, in the first bottle cap 12
Portion is equipped with internal screw thread, and 32 outer wall of the second interface channel of the 4th chamber 10 is equipped with external screw thread, and internal screw thread and external screw thread cooperate, can
To realize that the connection cover of the first bottle cap 12 and the 4th chamber 10 is closed, it can protect the liquid sample stored in the 4th chamber 10 in this way, make
Obtaining the liquid sample stored in the 4th chamber 10 will not leak out or be destroyed.
In some preferred modes, as shown in fig. 6, the first bottle cap 12 can be fixed on lid 7, table on lid 7
Face is equipped with pit 38, and 38 medium position of pit is provided with pillar 39, be inside pillar 39 it is hollow, 39 upper end of pillar has first
Aperture 43, in some preferred modes, as shown in figure 5, being equipped with the cylinder cooperated with the first aperture 43 inside the first bottle cap 12
40, the first aperture 43 can be inserted in cylinder 40, realizes the combination of the first bottle cap 12 and lid 7；In some preferred modes, such as
Shown in 5-6 figure, pillar 39 is cylindrical shape, and cylinder 40 is cylindrical body, and cylindrical body 40 can be inserted inside cylindric pillar 39, real
Both existing combination, in some preferred modes, as shown in figure 5, circular side wall 42 is additionally provided with inside the first bottle cap 12, circle
Shape side wall 42 is centered around 40 periphery of cylinder, as shown in fig. 6,39 lateral wall of pillar is equipped with convex rib 41, circular side wall 42 can be with
Convex rib 41 cooperates, and fastens the combination of the first bottle cap 12 and lid 7；In some preferred modes, convex rib 41 can be more
Item, in some preferred modes, a plurality of convex rib 41 is uniformly arranged on the lateral wall of pillar 39, and the setting of convex rib 41 can be with
For fixing the first bottle cap 12, when needed, the first bottle cap 12 can be extracted, lid 7 is detached from, 12 Gai of the first bottle cap
On second interface channel 32 of four chambers 10, the 4th chamber 10 is closed by realization.
Further, the linkage element includes lid 7, and in some preferred modes, lid is equipped with arrow, according to
Direction shown in arrow rotates, and can screw lid 7, and the constantly lid of lid 7 is made to close the first chamber；It is described in some preferred modes
Can link the detecting element and/or the separating element when lid conjunction of lid 7；The lid of lid 7 closes the process of the first chamber 1, namely
The process of lid 7 is constantly rotated, tightens, lid 7 constantly moves down, and lid 7 is contacted with inserted sheet 21, then, continues to backspin
Hub cap body 7, inserted sheet 21 is under pressure, and moves down, so that detecting element is mobile；Such as Fig. 1-2, shown in 16, lid 7 with
Separating element connection, then, the lid of lid 7 closes the process of the first chamber 1, namely constantly rotates, tightens the process of lid 7, and lid 7 is not
Disconnected to move down, separating element also will constantly move down, so, when lid conjunction of lid 7 can link the detecting element and/or
The separating element.In some preferred modes, it can close up with the first chamber downwards when the lid of lid 7 closes, lid 7 is moving down
While, inserted sheet 21 can be pushed, inserted sheet 21 can be in the second intracavitary movement, to make detecting element in the second intracavitary movement.
In some preferred modes, cup body further includes supporting side walls 51, and as shown in Figs. 1-2, supporting side walls 51 are arc
Side wall, supporting side walls 51 are fixedly connected with the side wall of the first chamber, and in some preferred modes, supporting side walls 51 are not wrapped completely
Enclose the surrounding of the 4th chamber 10, but leaving certain gaps uncovered by the economic plan, the 4th chamber 10 is installed or dismantled in this way convenient for user；Some preferred
In mode, 51 bottom of supporting side walls be it is horizontal, supporting side walls 51 are horizontally arranged in the horizontal plane, are made so entire
Device can be placed steadily, be readily transported or detect, in some preferred modes, supporting side walls 51 setting with the second chamber
Whole device can be better balanced in opposite position in this way, place device more steady.
The present invention also provides the application methods of the detection device, are retouched presently in connection with the embodiment in attached drawing 1-22
It states.As shown in figure 15, detection device is in original state, at this point, inserted sheet 21 is in the second chamber, bolt 23 is inserted in jack 22
In, a liquid relief area 6 of third chamber is connected to the opening 4 of the first chamber 1, another liquid relief area is connected to close to wall surface 9, the 4th chamber
On first chamber, the tip 35 of separating element is in the first interface channel 31, and lid 7 is not contacted with bolt 23；
Firstly, (1) opens lid 7, liquid sample is added into the first chamber 1, as shown in figure 16；First chamber 1 and the 4th
Chamber connection, liquid sample can flow into the 4th chamber 10 by the first interface channel of the first chamber, the liquid sample in the 4th chamber 10, constantly
Increase, after the liquid sample in the 4th chamber 10 is filled, liquid sample can store in the first chamber 1, liquid-like in the first chamber 1
This can enter third chamber by opening 4, as shown in figure 17；
Secondly, (2) rotate lid 7, lid 7 is closed into the first chamber to lower cover, during this, lid 7 links separating element not
Disconnected to enter the 4th chamber 10, lid 7 contacts bolt 23, and inserted sheet moves down, and detecting element also moves down, third chamber liquid relief area
It constantly moves down, third chamber liquid relief area can constantly store liquid sample until full of liquid relief area, as shown in figure 18；Continue to rotate
Lid 7, the liquid in third chamber liquid relief area constantly enter the second chamber, until the lid completely of lid 7 closes the first chamber 1, such as Figure 19-20
Shown, inserted sheet 21 is depressed into minimum, connected state is between third chamber and the second chamber, the liquid sample in third chamber turns completely
It moves on in the collet of the second chamber, pattern detection can be carried out at this time；
(3) after detection is completed, by observing the lateral surface of the second chamber, i.e. readable, because cup body is arranged to transparent
, also conveniently photograph to record testing result；As shown in figure 20, since the first chamber and the 4th chamber 10 are separated by separating element completely,
The first bottle cap 12 and the 4th chamber 10 can be removed at this time, and the first bottle cap 12 is screwed and is covered on the 4th chamber 10, the liquid of the 4th chamber 10
Body can be used for secondary-confirmation detection.
Claims (15)
1. a kind of detection device, characterized in that including the first chamber for collection and for the second chamber of detection, second chamber
It is interior to be equipped with detecting element, it can be closed and be connected between the first chamber and the second chamber, further include the third chamber quantitative for sample,
Sample quantitatively can be transferred to the second chamber from the first chamber by third chamber.
2. a kind of detection device according to claim 1, characterized in that the first chamber is opened equipped with what can be connected to third chamber
Mouthful.
3. a kind of detection device according to claim 2, characterized in that third chamber can respectively with the first chamber or the second chamber
Connection.
4. a kind of detection device according to claim 1, characterized in that third chamber is equipped with sealing structure.
5. a kind of detection device according to claim 1, characterized in that the third chamber includes that at least one is used for sample
This is transferred to the liquid relief area of the second chamber from the first chamber.
6. a kind of detection device according to claim 1, characterized in that the detecting element can be in the second intracavitary shifting
It is dynamic.
7. a kind of detection device according to claim 6, characterized in that the third chamber can be mobile with detecting element,
To be connected to respectively with the first chamber or the second chamber.
8. a kind of detection device according to claim 6, characterized in that including linkage element, the linkage element can
Drive the detecting element mobile.
9. a kind of detection device according to claim 8, characterized in that the described second intracavitary be equipped with can allow for third chamber
The channel that interior sample enters.
10. a kind of detection device according to claim 1, characterized in that further include for collecting secondary-confirmation detection sample
This 4th chamber, the 4th chamber can be connected to or separate with the first chamber.
11. a kind of detection device according to claim 10, characterized in that further include for be connected to or separate the first chamber and
The separating element of 4th chamber.
12. a kind of detection device according to claim 11, characterized in that including linkage element, the linkage element energy
It is enough to link with the separating element so that separating element is connected to or separates the first chamber and the 4th chamber.
13. a kind of detection device according to claim 12, characterized in that when the separating element separates first chamber
When with four chambers, the first chamber can be separated from the 4th chamber.
14. a kind of detection device according to claim 8 or 12, characterized in that the linkage element includes lid, described
Can link the detecting element and/or the separating element when cover cap conjunction.
15. a kind of detection device according to claim 1, characterized in that the detecting element and the detection device
There is certain angle between bottom.
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| CN201910689936.2A CN110404596A (en) | 2019-07-29 | 2019-07-29 | A kind of detection device |
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| CN201910689936.2A CN110404596A (en) | 2019-07-29 | 2019-07-29 | A kind of detection device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112326974A (en) * | 2020-11-02 | 2021-02-05 | 杭州博拓生物科技股份有限公司 | Detection device |
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