CN110403606A - A kind of lung function breathing detection uses mixed gas - Google Patents
A kind of lung function breathing detection uses mixed gas Download PDFInfo
- Publication number
- CN110403606A CN110403606A CN201910609276.2A CN201910609276A CN110403606A CN 110403606 A CN110403606 A CN 110403606A CN 201910609276 A CN201910609276 A CN 201910609276A CN 110403606 A CN110403606 A CN 110403606A
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- gas
- nitrogen
- finished product
- medical grade
- carbon monoxide
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/10—Mixing gases with gases
Abstract
The present invention provides a kind of lung function breathing detections to use mixed gas, it is characterised in that: by gas raw material carbon monoxide, helium or methane, residual air is Medical grade oxygen and nitrogen, according to following percent by volume: carbon monoxide 0.26%~0.32%；Helium 9.60%~10.00% (or methane 0.29%~0.32%)；Residual air is Medical grade oxygen and nitrogen, medical grade oxygen percent by volume is 21% in residual air, nitrogen percent by volume is 79%, carry out mixed gas configuration, the weight M1 of finished product gas bomb is first recorded before punching dress, unstrpped gas is successively filled with by the requirement of formula again: carbon monoxide, methane or helium, nitrogen, Medical grade oxygen, and it is corresponding in turn to and records finished product gas bomb weight M2, M3, M4, M5 for being filled with gas, further according to gas perfect condition equation P V=NRT, the proportional amount of various gases is calculated.The present invention further increases pulmonary diffusion function detection validity and accuracy further increases the therapeutic time of patient to the reproducible of testing result.
Description
Technical field
The present invention relates to medicine breathing detection fields, and in particular to a kind of lung function breathing detection uses mixed gas.
Background technique
Pulmonary diffusion function refers to certain alveolar air by alveolar-capillary membrane (by alveolar epithelium and its basilar memebrane, alveolar
Connective tissue between capillary endothelium and its basilar memebrane and 2 basilar memebranes is constituted) it is spread from alveolar to capillary
To blood, and the ability combined with the hemoglobin (Hb) in red blood cell.The gas swapped in alveolar-capillary membrane
Mainly oxygen (O2) and carbon dioxide (CO2).It is average that diffusing capacity due to directly calculating oxygen need to measure pulmonary capillaries blood oxygen
Partial pressure, method are complicated；And the binding force of carbon monoxide (CO) and hemoglobin is than oxygen O2It is 210 times big, the oxygen in physiological range
Partial pressure is not a main interference factors；In addition to a large amount of smokers, carbon monoxide content is almost nil in human normal plasma, is convenient for
Calculate the intake of carbon monoxide in checking；And carbon monoxide is seldom dissolved in blood plasma in transport process, so an oxygen
Changing carbon becomes the perfect gas of measurement pulmonary diffusion function.1915, Krogh proposed to use carbon monoxide at first according to disperse principle
It measures diffusing capacity of the lung (DLCO).
Pulmonary diffusion function, which is carried out, using carbon monoxide checks that there are many different methods, including one breath Breathing Method, an oxygen
Change carbon uptake assay, steady state method, rebreathing method and the internal respiration method easy to operate that need not be held one's breath of latest developments, but with
One breath Breathing Method diffusing capacity of the lungs for carbon monoxide (DLCOsingle-breathmethod, DLCO-of the foundation such as Ogilvie
Sb) the most commonly used.But as directly allow patient be directly sucked in carbon monoxide be it is harmful, can not also determine other sucking amount whether
Enough amounts.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of lung function breathing detections to use mixed gas.
In order to solve the above technical problems, technical solution provided by the invention are as follows:
A kind of lung function breathing detection uses mixed gas, it is characterised in that: its constituent percent by volume an are as follows: oxygen
Change carbon 0.26%~0.32%, helium 9.60%~10.00%, methane 0.29%~0.32%, residual air be Medical grade oxygen and
Nitrogen.
Preferably, it is characterised in that: its constituent percent by volume are as follows: carbon monoxide 0.26%~0.30%, helium
9.60%~10.00%, residual air is Medical grade oxygen and nitrogen.
Preferably, it is characterised in that: its constituent percent by volume are as follows: carbon monoxide 0.29%~0.32%, methane
0.29%~0.32%, residual air is Medical grade oxygen and nitrogen.
Preferably, it is characterised in that: medical grade oxygen percent by volume is 21% in the residual air, nitrogen percent by volume
It is 79%.
A kind of lung function breathing detection uses the preparation method of mixed gas, it is characterised in that: including the following steps:
The first step, gas raw material required for preparing: the first that carbon monoxide that purity is 99.99%, purity are 99.99%
Nitrogen that person's helium that alkane or purity are 99.999%, Medical grade oxygen, purity are 99.999% and two meet national standard
The finished product gas bomb (5) of GB5099 model；
Second step, processing contain the finished product gas bomb of mixed gas: first with electrically heated baking oven finished product gas bomb
Heated, when oven temperature reaches 80 DEG C；Start rotary-vane vaccum pump and carry out finished product gas bomb vacuumize process,
It when the reading of gauge reaches 5Pa, fills a small amount of nitrogen and is replaced and vacuumize again, in triplicate nitrogen displacement and vacuum meter
Counting reaches 5Pa, i.e. finished product gas bomb processing is completed；
Third step is ready for mixed gas and fills when finished product gas bomb temperature is reduced to room temperature, and needs before punching dress
Finished product gas bomb is weighed with precise electronic and is recorded as M1；
4th step, the first unstrpped gas steel cylinder, the second unstrpped gas steel cylinder, third unstrpped gas steel cylinder, the 4th raw material
Gas bomb and finished product gas bomb are connected on distributing cabinet, and the vacuum pump for opening distributing cabinet carries out pipeline and vacuumizes, and replaces
Three times, go out further according to PV=NRT gas perfect condition equation calculation and be formulated various gas weights；
5th step is successively filled with unstrpped gas by the requirement of formula: carbon monoxide, methane or helium, nitrogen, medical grade
Oxygen, and be corresponding in turn to and record weight M2, M3, M4, M5 for being filled with gas, it can therefrom calculate the weight of carbon monoxide
Are as follows: M2 subtracts M1, the weight of methane or helium are as follows: M3 subtracts M2, nitrogen weight are as follows: M4 subtracts M3, the weight of oxygen are as follows: M5
M4 is subtracted, further according to gas perfect condition equation P V=NRT, calculates the proportional amount of various gases.
The present invention has the advantage that being sucked through research test a kind of containing carbon monoxide, methane or helium, oxygen and nitrogen
Diversity gas, then examined to detect its pulmonary diffusion function, significant effect, accuracy is high, smaller to the injury of human body；Mixing
The formula of gas further improves pulmonary diffusion function detection validity and further does high trouble to the reproducible of testing result
The therapeutic time of person；Pulmonary diffusion function testing result is preferable, can achieve Effective Numerical.
Detailed description of the invention
Fig. 1 is the preparation facilities figure that a kind of lung function breathing detection uses mixed gas.
It is as shown in the figure: 1, the first unstrpped gas steel cylinder；2, the second unstrpped gas steel cylinder；3, third unstrpped gas steel cylinder；4,
4th unstrpped gas steel cylinder；5, finished product gas bomb；6, Precision Electronics Balance；7, distributing cabinet；8, the first valve；9, the second valve；
10, first pressure gauge；11, second pressure gauge；12, the first connection tracheae；13, air inlet pipe；14, escape pipe；15, the second connection gas
Pipe.
Specific embodiment
Hereinafter, an embodiment of the invention is illustrated referring to attached drawing 1.
A kind of lung function breathing detection uses mixed gas, it is characterised in that: its constituent percent by volume an are as follows: oxygen
Change carbon 0.26%~0.32%, helium 9.60%~10.00%, methane 0.29%~0.32%, residual air be Medical grade oxygen and
Nitrogen.
Its described constituent percent by volume are as follows: carbon monoxide 0.26%~0.30%, helium 9.60%~
10.00%, residual air is Medical grade oxygen and nitrogen.
Its described constituent percent by volume are as follows: carbon monoxide 0.29%~0.32%, methane 0.29%~0.32%,
Residual air is Medical grade oxygen and nitrogen.
Medical grade oxygen percent by volume is 21% in the residual air, and nitrogen percent by volume is 79%.
A kind of lung function breathing detection uses the preparation method of mixed gas, it is characterised in that: including the following steps:
The first step, gas raw material required for preparing: the first that carbon monoxide that purity is 99.99%, purity are 99.99%
Nitrogen that person's helium that alkane or purity are 99.999%, Medical grade oxygen, purity are 99.999% and two meet national standard
The finished product gas bomb (5) of GB5099 model；
Second step, processing contain the finished product gas bomb 5 of mixed gas: first with electrically heated baking oven finished product gas bomb
5 are heated, when oven temperature reaches 80 DEG C；Starting rotary-vane vaccum pump carries out finished product gas bomb 5 and vacuumizes place
Reason when the reading of gauge reaches 5Pa, fills a small amount of nitrogen and is replaced and vacuumize again, in triplicate nitrogen displacement and true
Sky meter, which counts, reaches 5Pa, i.e. the processing of finished product gas bomb 5 is completed；
Third step is ready for mixed gas and fills when 5 temperature of finished product gas bomb is reduced to room temperature, and before punching dress
It needs finished product gas bomb 5 to be claimed 6 to be weighed with precise electronic and be recorded as M1；
4th step, the first unstrpped gas steel cylinder 1, the second unstrpped gas steel cylinder 2, third unstrpped gas steel cylinder the 3, the 4th is former
Material gas bomb 4 and finished product gas bomb 5 are connected to together on distributing cabinet 7, and the vacuum pump for opening distributing cabinet 7 carries out pipeline and takes out very
Sky, and replace three times, go out further according to PV=NRT gas perfect condition equation calculation and is formulated various gas weights；
5th step is successively filled with unstrpped gas by the requirement of formula: carbon monoxide, methane or helium, nitrogen, medical grade
Oxygen, and be corresponding in turn to and record weight M2, M3, M4, M5 for being filled with gas, it can therefrom calculate the weight of carbon monoxide
Are as follows: M2 subtracts M1, the weight of methane or helium are as follows: M3 subtracts M2, nitrogen weight are as follows: M4 subtracts M3, the weight of oxygen are as follows: M5
M4 is subtracted, further according to gas perfect condition equation P V=NRT, calculates the proportional amount of various gases.
Such as attached drawing 1, a kind of lung function breathing detection according to the present invention uses the device of mixed gas, and feature exists
In: including the first unstrpped gas steel cylinder 1, the second unstrpped gas steel cylinder 2, third unstrpped gas steel cylinder 3, the 4th unstrpped gas steel cylinder
4, distributing cabinet 7 and finished product gas bomb 5, the first unstrpped gas steel cylinder 1 are equipped with carbon monoxide, the second unstrpped gas steel
Bottle 2 is equipped with helium or methane, and the third unstrpped gas steel cylinder 3 is equipped with nitrogen, and the 4th unstrpped gas steel cylinder 4 is equipped with doctor
With grade oxygen, the side of the distributing cabinet 7 is equipped with air inlet pipe 13, and the other side of the distributing cabinet 7 is equipped with escape pipe 14, described to match
Gas holder is equipped with first pressure gauge 10 and second pressure gauge 11, and the first pressure gauge 10 is respectively arranged below with the first valve 8,
The second pressure gauge 11 is respectively arranged below with the second valve 9, the first unstrpped gas steel cylinder 1, the second unstrpped gas steel
Bottle 2, third unstrpped gas steel cylinder 3 and the 4th unstrpped gas steel cylinder 4 are connected to air inlet pipe 13 by the second connection tracheae 15, described
Finished product gas bomb 5 is connected to escape pipe 14 by the first connection tracheae 12, and the downside of the finished product gas bomb 5 is equipped with precision
Electronic scale 6.The volume of the finished product gas bomb 5 is 40L, and valve is QF-2 or PX-32, and meets 5099 type of standard GB/T
Number.
Clinical detection: generally in terms of clinical application, the indexs such as DLCO, DLCO/VA are directly with the 80% of predicted value
Lower limits of normal is considered as exception lower than the value, by using above-mentioned apparatus and according to the mixed gas of above-mentioned steps configuration, through big
The clinical application of amount, pulmonary diffusion function testing result is preferable, can achieve Effective Numerical.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., is all included in the scope of protection of the present invention.
Claims (5)
1. a kind of lung function breathing detection uses mixed gas, it is characterised in that: its constituent percent by volume are as follows: an oxidation
Carbon 0.26%~0.32%, helium 9.60%~10.00%, methane 0.29%~0.32%, residual air are Medical grade oxygen and nitrogen
Gas.
2. a kind of lung function breathing detection according to claim 1 uses mixed gas, it is characterised in that: its constituent
Percent by volume are as follows: carbon monoxide 0.26%~0.30%, helium 9.60%~10.00%, residual air are Medical grade oxygen and nitrogen
Gas.
3. a kind of lung function breathing detection according to claim 1 uses mixed gas, it is characterised in that: its constituent
Percent by volume are as follows: carbon monoxide 0.29%~0.32%, methane 0.29%~0.32%, residual air are Medical grade oxygen and nitrogen
Gas.
4. a kind of lung function breathing detection according to any one of claims 1 to 3 uses mixed gas, it is characterised in that: institute
Stating medical grade oxygen percent by volume in residual air is 21%, and nitrogen percent by volume is 79%.
5. the preparation method that a kind of lung function breathing detection uses mixed gas, it is characterised in that: including the following steps:
The first step, gas raw material required for preparing: methane that carbon monoxide that purity is 99.99%, purity are 99.99% or
Nitrogen that person's helium that purity is 99.999%, Medical grade oxygen, purity are 99.999% and two meet national standard
The finished product gas bomb (5) of GB5099 model；
Second step, processing contain the finished product gas bomb (5) of mixed gas: first with electrically heated baking oven finished product gas bomb
(5) heated, when oven temperature reaches 80 DEG C；Start rotary-vane vaccum pump and carries out finished product gas bomb (5) pumping very
Vacancy reason when the reading of gauge reaches 5Pa, fills a small amount of nitrogen and is replaced and vacuumize again, and nitrogen is replaced in triplicate
And vacuum meter counting reaches 5Pa, i.e. finished product gas bomb (5) processing is completed；
Third step is ready for mixed gas and fills when finished product gas bomb (5) temperature is reduced to room temperature, and needs before punching dress
Claim (6) to be weighed with precise electronic finished product gas bomb (5) and is recorded as M1；
4th step, the first unstrpped gas steel cylinder (1), the second unstrpped gas steel cylinder (2), third unstrpped gas steel cylinder (3), the 4th
Unstrpped gas steel cylinder (4) and finished product gas bomb (5) are connected to together on distributing cabinet (7), open distributing cabinet (7) vacuum pump into
Row pipeline vacuumizes, and replaces three times, goes out further according to PV=NRT gas perfect condition equation calculation and is formulated various gas weights；
5th step is successively filled with unstrpped gas by the requirement of formula: carbon monoxide, methane or helium, nitrogen, medical grade oxygen
Gas, and be corresponding in turn to and record weight M2, M3, M4, M5 for being filled with gas, it can therefrom calculate the weight of carbon monoxide are as follows:
M2 subtracts M1, the weight of methane (or helium) are as follows: M3 subtracts M2, nitrogen weight are as follows: M4 subtracts M3, the weight of oxygen are as follows: M5
M4 is subtracted, further according to gas perfect condition equation P V=NRT, calculates the proportional amount of various gases.
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| CN201910609276.2A CN110403606A (en) | 2019-07-08 | 2019-07-08 | A kind of lung function breathing detection uses mixed gas |
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| CN201910609276.2A CN110403606A (en) | 2019-07-08 | 2019-07-08 | A kind of lung function breathing detection uses mixed gas |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111840743A (en) * | 2020-07-21 | 2020-10-30 | 清远市联升空气液化有限公司 | Preparation method of standard mixed gas for treating persistent pulmonary artery height of newborn |
| CN113854997A (en) * | 2021-09-24 | 2021-12-31 | 中国科学院合肥物质科学研究院 | Lung dispersion function inspection device and method based on one-breath method |
| CN117387000A (en) * | 2023-12-13 | 2024-01-12 | 抚顺抚运安仪救生装备有限公司 | Gas concentration detection and supplement system for premixed gas cylinder of deep diving breathing apparatus |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111840743A (en) * | 2020-07-21 | 2020-10-30 | 清远市联升空气液化有限公司 | Preparation method of standard mixed gas for treating persistent pulmonary artery height of newborn |
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| CN113854997B (en) * | 2021-09-24 | 2024-04-05 | 中国科学院合肥物质科学研究院 | Lung dispersion function inspection device and method based on one-touch method |
| CN117387000A (en) * | 2023-12-13 | 2024-01-12 | 抚顺抚运安仪救生装备有限公司 | Gas concentration detection and supplement system for premixed gas cylinder of deep diving breathing apparatus |
| CN117387000B (en) * | 2023-12-13 | 2024-04-09 | 抚顺抚运安仪救生装备有限公司 | Gas concentration detection and supplement system for premixed gas cylinder of deep diving breathing apparatus |
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