CN108186019A - A kind of Exhaled nitric oxide measuring method for not needing to control expiratory gas flow - Google Patents
A kind of Exhaled nitric oxide measuring method for not needing to control expiratory gas flow Download PDFInfo
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- CN108186019A CN108186019A CN201711361686.7A CN201711361686A CN108186019A CN 108186019 A CN108186019 A CN 108186019A CN 201711361686 A CN201711361686 A CN 201711361686A CN 108186019 A CN108186019 A CN 108186019A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B2010/0083—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements for taking gas samples
- A61B2010/0087—Breath samples
Abstract
The invention discloses a kind of Exhaled nitric oxide measuring methods for not needing to control expiratory gas flow, analysis is sampled more than airway dead space air volume more than sustained exhalation under conditions of 5cmH2O and expiration total volume to breath pressure including on-line measurement, and control exhalation time, breathe out flow and other correlated variables (such as air flue flow and pressure), the content of eNO is measured in real time, measure the expiration NO concentration at least one expiratory duration point, it is required that testee ensures accurately to measure required exhalation flow and pressure and other parameters, the testee that can coordinate this can obtain measurement result quickly, its advantage is：A kind of Exhaled nitric oxide measuring method for not needing to control expiratory gas flow is provided, it is from air flue or alveolar that disease, which can be distinguished, parameter is independent of flow, multithread measurement can be carried out with different methods, it can differentiate the NO metabolic conditions of healthy testee, the expiration NO concentration measured its expiration NO concentration and be converted under the conditions of ATS standards are exhaled.
Description
Technical field
The present invention relates to a kind of Exhaled nitric oxide measuring technique methods, do not need to control more particularly, to one kind and exhale
The Exhaled nitric oxide measuring method of flow.
Background technology
Chronic cough, asthma and it is uncomfortable in chest etc. be that outpatient service is common, usual mistaken diagnosis is asthma.These symptoms do not have special simultaneously
Property, need complicated antidiastole that can just be made a definite diagnosis, in fact, chronic obstructive pulmonary disease (COPD), gastroesophageal reflux (GORD), anxiety companion
Asthma, pulmonary function test, invertibity experiment and expiration are also often misdiagnosed as with hyperventilation and slight bronchiectasis etc.
The airway physiologies functional tests such as peak flow (PEF) are usually used to assisted diagnosis, are not easy however, obtaining correct PEF numerical value,
Patient's cooperation is also not easy.Moreover, these methods due to poor sensitivity with specificity and apply be restricted.In addition, it
The effect of cannot predicting ICS, and the effect of predicting ICS, is highly useful to the Managed Solution of rational respiratory disease, and asthma is most
Common pathological characters are acidophilia airway inflammations.Acidophilia airway inflammation has reaction to ICS class drugs.ENO is acidophilia
The marker of airway inflammation, can be used for diagnosing and antidiastole asthma, especially prediction steroid medicine curative effect aspect are very only
To with it is notable.Moreover, eNO measure is capable of providing the pathological information that symptom and airway physiology inspection cannot provide, outpatient service is especially
The diagnostic means of clinic are extremely limited.To non-specific respiratory disease, eNO can be combined or be used alone with lung function tests, no
The level of Clinics and Practices monitoring can be only improved, and clinical confidence can be increased.
NO can be used for improving Asthma control as airway inflammation biomarker, although some clinical tests have shown that
Symptom and the conventional method of lung function tests can be replaced with eNO monitorings, and with higher value, at present, in baby and
The cheyne-stokes respiration detection technique applied with child not yet forms unified standard, still there are many problem it is to be solved, it is most important such as
Reproducibility problem, oral cavity FENO depends on exhalation flow rate, in the cheyne-stokes respiration from principal flow velocity, it is difficult to obtain significant figure
According to moreover, the NO from ambient enviroment and the upper respiratory tract will be mixed, in the exhaled gas thus collected to exclude such factor
It influences, it is preferred to use mask or dual chamber mask.
Invention content
In view of the deficiencies of the prior art, exhaling for control expiratory gas flow is not needed to the purpose of the present invention is to provide a kind of
Outlet nitric oxide measurement method, it is from air flue or alveolar that can distinguish disease, and parameter can use difference independent of flow
Method carry out multithread measurement, can differentiate the NO metabolic conditions of healthy testee, measure its expiration NO concentration and convert
Expiration NO concentration under the conditions of exhaling into ATS standards.
Technical scheme of the present invention is summarized as follows：
A kind of Exhaled nitric oxide measuring method for not needing to control expiratory gas flow is described as follows：
On-line measurement is more than airway dead space to breath pressure more than sustained exhalation under conditions of 5cmH2O and expiration total volume
Air volume is sampled analysis, and controls exhalation time, exhalation flow and other correlated variables (such as air flue flow and pressure),
The content of eNO is measured in real time, measures the expiration NO concentration at least one expiratory duration point, it is desirable that testee ensures accurately
Measurement result can be obtained quickly by measuring required exhalation flow and pressure and other parameters, the testee that can coordinate this；
Allow detected person according to setting flow rates and pass through an expiratory resistance reach standard requirement flow velocity (such as
Demonstrated using measuring instrumentss or computer), it can be controlled than the pressure of exhalation and more easily reach required flow, flow is to determine
The principal element of eNO levels；
Wherein under the conditions of single breath, as long as keeping exhalation flow rate constant, the exhalation NO that can just form same pattern is dense
Degree-time changing curve, curve just enter plateau after experience row washes the phase, and plateau has reproducibility, usually very steady,
Possible updip has a down dip, and sometimes, row peak value followed by occurs after washing the phase, when observation object nose or is starting air-breathing
When soft palate be in open configuration, the NO in nasal cavity will be formed with upward peak, suck NO in air or when observation object air-breathing
It is not breathed out in time after to total lung capacity and NO is made to accumulate in oral cavity and lower respiratory tract, can all generate similar phenomenon, this peak value can
To ignore, it is important that the analysis platform phase；
NO curves are divided with 3 seconds (0.15L) for unit, it is assumed that starting point A, terminal B, the AB slope of curve can be
Zero, positive value or negative value, if AB curves be occur earliest on NO curves, slope absolute value less than 10% and fluctuation range
Between the three-second area within 10%, then its mean value can be used to represent oral cavity eNO, once obtain more than mean value, detected person
Stop exhaling, in oral cavity eNO less than in the case of 10ppb, it is contemplated that the changes such as instrument accuracy of detection and the control of patient's exhalation flow rate
Amount factor, the operability that 10% NO concentration plateaus weigh principle are poor；It has been generally acknowledged that the fluctuation range of AB curves exists
It can receive within 1ppb, on-line analysis device will be according to more than principle automatic identification NO plateaus, by the expiration of 0.05L/s
Flow velocity, NO plateaus, are usually very gentle, and easily identify；
Expiration program should be repeated at least twice, and to obtain the measured value that two gaps are no more than 10%, their mean value is just
It is horizontal to represent oral cavity NO exhalation, in some cases, when such as measuring NO contents with different exhalation flow rates, procedure above preferably takes
Three effective FENO are obtained, after every wheel is exhaled, detected person should at least be allowed to rest 30 seconds, when patient does not feel like oneself
Time not carry out duplicate measurements.
Preferably, the NO outputs represent the amount of the NO in expiratory air, are represented with VNO, calculate NO in every liter of expiratory air
Concentration, unit for nanoliter, calculate expiratory gas flow per minute, for unit to rise, calculation formula is as follows：
VNO (nl/minute)=NO (nl/L) ' flows (L/minute).
Preferably, the plateau generated in NO, instantaneous flow is not less than 0.045L/S, not higher than 0.055L/S,
If testee cannot be maintained within the scope of this, then result should be used as and measure failure.
Preferably, the control expiratory resistance is more than 5cmH2O, the premise of soft palate is closed described in this ATS standard, herein
Under the conditions of can avoid the interference of upper respiratory tract NO (nasal cavity), (need not be controlled second is that sustained exhalation total volume is more than air flue dead volume
Expiratory gas flow),
Described to be breathed out immediately with after oral inhalation, exhalation flow rate is maintained at 0.05L/s, pressure be maintained at 5-20cm H2O with
It is closed soft palate, the time at least keeps four seconds until NO maintenance levels reach 2 seconds or more, for the children of less than 12 years old, expiration
At least four seconds time；For the children of 12 years old or more, expiratory duration at least six seconds,
It is described it based on expiration NO gas exchanges two compartment models, changed by measuring in moisture exhalation process NO concentration
The anti-expiration NO concentration pushed away under standard expiratory gas flow of numerical value when reaching stable state, moisture is can adjust by changing moisture expiratory resistance
According to multiple expiratory gas flows and corresponding stable state expiration NO concentration, the items of expiration NO are solved by numerical algorithm for expiratory gas flow
Parameter.
Preferably, it is described rest repeat after 30 seconds it is above inhale expiration program, repeat two to three times, with acquisition two to three
Oral cavity FENO stationary value of a fluctuation within 10%；Or repeat twice, to obtain oral cavity of two fluctuations within 5%
FENO stationary values for the preprimary child for being difficult to reach exhalation flow rate and pressure requirements, can use audiovisuals and flow controller etc.
Supplementary means, audiovisuals can prompt whether air-breathing reaches total lung capacity position, and help to control exhalation flow rate, and flow controller makes children
The exhalation flow rate kept constant is remained in the case where mouth pressure changes.
The beneficial effects of the invention are as follows：By providing simulation output and numeral output simultaneously, data collection is by NO testing numbers
According to computer or monitor is delivered to, to accomplish display results in real time, when occurring effective NO plateaus, you can terminate to exhale.,
Data storage maintenance data analysis software handles and shows test result, and the biofeedback of expiration parameter is to keeping constant flow rate extremely
Close important, the optional control system of sampling velocity includes dynamic flow resistor and mass flow controller etc., to realize to NO
The automatic monitoring and display of sample flow rate, as long as the sustained exhalation under conditions of breath pressure is more than 5cmH2O, in exhalation process
It is middle to monitor in real time and record expiratory flow-volume curve, the expiration NO concentration at least one expiratory duration point is measured, then basis is exhaled
Throughput curve and measured expiration NO concentration calculate expiration parameters, and this method can also be used for cheyne-stokes respiration sampling analysis
Exhaled nitric oxide concentration.
Specific embodiment
The present invention is clearly and completely described with reference to embodiment, it is clear that described embodiment is only this
Invention part of the embodiment, instead of all the embodiments, based on the embodiments of the present invention, those of ordinary skill in the art exist
All other embodiments obtained under the premise of creative work are not made, shall fall within the protection scope of the present invention.
It is as follows the present invention provides a kind of Exhaled nitric oxide measuring method for not needing to control expiratory gas flow：
On-line measurement is more than airway dead space to breath pressure more than sustained exhalation under conditions of 5cmH2O and expiration total volume
Air volume is sampled analysis, and controls exhalation time, exhalation flow and other correlated variables (such as air flue flow and pressure),
The content of eNO is measured in real time, measures the expiration NO concentration at least one expiratory duration point, it is desirable that testee ensures accurately
Measurement result can be obtained quickly by measuring required exhalation flow and pressure and other parameters, the testee that can coordinate this；
Allow detected person according to setting flow rates and pass through an expiratory resistance reach standard requirement flow velocity (such as
Demonstrated using measuring instrumentss or computer), it can be controlled than the pressure of exhalation and more easily reach required flow, flow is to determine
The principal element of eNO levels；
Wherein under the conditions of single breath, as long as keeping exhalation flow rate constant, the exhalation NO that can just form same pattern is dense
Degree-time changing curve, curve just enter plateau after experience row washes the phase, and plateau has reproducibility, usually very steady,
Possible updip has a down dip, and sometimes, row peak value followed by occurs after washing the phase, when observation object nose or is starting air-breathing
When soft palate be in open configuration, the NO in nasal cavity will be formed with upward peak, suck NO in air or when observation object air-breathing
It is not breathed out in time after to total lung capacity and NO is made to accumulate in oral cavity and lower respiratory tract, can all generate similar phenomenon, this peak value can
To ignore, it is important that the analysis platform phase；
NO curves are divided with 3 seconds (0.15L) for unit, it is assumed that starting point A, terminal B, the AB slope of curve can be
Zero, positive value or negative value, if AB curves be occur earliest on NO curves, slope absolute value less than 10% and fluctuation range
Between the three-second area within 10%, then its mean value can be used to represent oral cavity eNO, once obtain more than mean value, detected person
Stop exhaling, in oral cavity eNO less than in the case of 10ppb, it is contemplated that the changes such as instrument accuracy of detection and the control of patient's exhalation flow rate
Amount factor, the operability that 10% NO concentration plateaus weigh principle are poor；It has been generally acknowledged that the fluctuation range of AB curves exists
It can receive within 1ppb, on-line analysis device will be according to more than principle automatic identification NO plateaus, by the expiration of 0.05L/s
Flow velocity, NO plateaus, are usually very gentle, and easily identify；
Expiration program should be repeated at least twice, and to obtain the measured value that two gaps are no more than 10%, their mean value is just
It is horizontal to represent oral cavity NO exhalation, in some cases, when such as measuring NO contents with different exhalation flow rates, procedure above preferably takes
Three effective FENO are obtained, after every wheel is exhaled, detected person should at least be allowed to rest 30 seconds, when patient does not feel like oneself
Time not carry out duplicate measurements.
Wherein NO outputs represent the amount of the NO in expiratory air, are represented with VNO, calculate the concentration of NO in every liter of expiratory air, single
Position for nanoliter, calculate expiratory gas flow per minute, for unit to rise, calculation formula is as follows：
VNO (nl/minute)=NO (nl/L) ' flows (L/minute).
By the plateau generated in NO, instantaneous flow is not less than 0.045L/S, not higher than 0.055L/S, if testee
It cannot be maintained within the scope of this, then result should be used as and measure failure.
And by the way that expiratory resistance is controlled to be more than 5cmH2O, this ATS standard is closed the premise of soft palate, can be kept away on this condition
Exempt from the interference of upper respiratory tract NO (nasal cavity), second is that sustained exhalation total volume is more than air flue dead volume (need not control expiratory gas flow),
It is breathed out immediately with after oral inhalation, exhalation flow rate is maintained at 0.05L/s, and pressure is maintained at 5-20cm H2O so that soft
Palate is closed, and the time at least keeps four seconds until NO maintenance levels reach 2 seconds or more, for the children of less than 12 years old, expiratory duration
At least four seconds；For the children of 12 years old or more, expiratory duration at least six seconds,
It is reached based on expiration NO gas exchanges two compartment models by measuring NO concentration variation in moisture exhalation process
The anti-expiration NO concentration pushed away under standard expiratory gas flow of numerical value during stable state can adjust moisture expiration by changing moisture expiratory resistance
According to multiple expiratory gas flows and corresponding stable state expiration NO concentration, the parameters of expiration NO are solved by numerical algorithm for flow.
And it by inhaling expiration program more than being repeated after resting 30 seconds, repeats two to three times, to obtain two to three waves
Move the oral cavity FENO stationary values within 10%；Or repeat twice, it is steady to obtain oral cavity FENO of two fluctuations within 5%
Definite value for the preprimary child for being difficult to reach exhalation flow rate and pressure requirements, can use the nondominant hands such as audiovisuals and flow controller
Section, audiovisuals can prompt whether air-breathing reaches total lung capacity position, and help to control exhalation flow rate, and flow controller makes children in oral cavity
Pressure remains to the exhalation flow rate kept constant in the case of changing.
Application Example 1：During patient's respiration, by sampling lasting at a constant flow rate, online side
Method is combined with the chemiluminescent analyzer of quick response can measure the concentration of NO, and the concentration for recording carbon dioxide may have
Help the analyzing and processing of data, it should be appreciated that the particularity of pipeline sampling, the characteristic of NO, carbon dioxide and flow are surveyed
Amount, the response time of Chemiluminescence Apparatus and time delay, for off-line measurement compared with the advantage there are many on-line measurements, one maximum
Advantage is exactly that can be analyzed in different times with different places with sampling, when off-line measurement does not depend on the expiration of patient
Between, the gas collection of off-line measurement is there are many different methods, and single is exhaled and repeatedly expiration can be adopted to analyze, and does not have
A kind of method of standard collects gas, and NO changes of contents is very big in the gas of these methods collection.
Application Example 2：Nostril is tightly clogged with two hollow noses.Material of having a stuffy nose should not generate negative shadow to human body
It rings, volume should be suitble to most of detected person with shape.Detected person sits down, and puts on mask, total to lung with a nostril air-breathing
Capability bit, then certain resistance is kept to exhale with another nostril, mouth pressure control is in 10cm H2O, in exhalation process, suction
Entering pump to supply for another nostril constant current by nasal obstruction, suction side nasal obstruction end is connected to side valve door, and sample is detected for collecting,
Another suitable alternative is that (such as medical compressed air) is with a nostril air-breathing under positive pressure constant current conditions, and passes through
Another nostril is exhaled, and this method is especially suitable for nasal obstruction and causes the situation that the wing of nose collapses.Nose may occur for air-breathing under positive pressure
Chamber gas loss, it is therefore necessary to confirm that soft palate is in closed state, when carrying out the detection of nasal cavity NO exhalation amount, breathing flow velocity should be protected
It holds between 0.25-3L/m, just can ensure that most detected persons obtain the NO concentration curve plateaus of 20-30 seconds.0.25L/m with
Under breathing flow velocity will improve NO absolute values, be suitable for detecting nasal cavity NO decrements that (such as congenital ciliary movement abnormality disease is suffered from
Person), in addition, low breathe the influence of environment NO of flow velocity also relative reduction, on the other hand, under the conditions of low breathing flow velocity, concentration
Retention time curve plateau phase is shorter, breathing flow velocity used by should all being recorded in each detection.
The beneficial effects of the invention are as follows：By providing simulation output and numeral output simultaneously, data collection is by NO testing numbers
According to computer or monitor is delivered to, to accomplish display results in real time, when occurring effective NO plateaus, you can terminate to exhale.,
Data storage maintenance data analysis software handles and shows test result, and the biofeedback of expiration parameter is to keeping constant flow rate extremely
Close important, the optional control system of sampling velocity includes dynamic flow resistor and mass flow controller etc., to realize to NO
The automatic monitoring and display of sample flow rate, as long as the sustained exhalation under conditions of breath pressure is more than 5cmH2O, in exhalation process
It is middle to monitor in real time and record expiratory flow-volume curve, the expiration NO concentration at least one expiratory duration point is measured, then basis is exhaled
Throughput curve and measured expiration NO concentration calculate expiration parameters, and this method can also be used for cheyne-stokes respiration sampling analysis
Exhaled nitric oxide concentration.
Although the embodiments of the present invention have been disclosed as above, but its be not restricted in specification and embodiment it is listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, it is of the invention and unlimited
In specific details and embodiment shown here.
Claims (5)
1. a kind of Exhaled nitric oxide measuring method for not needing to control expiratory gas flow, which is characterized in that described as follows：
On-line measurement is more than airway dead space gas to breath pressure more than sustained exhalation under conditions of 5cmH2O and expiration total volume
Product is sampled analysis, and controls exhalation time, exhalation flow and other correlated variables (such as air flue flow and pressure), in real time
The content of eNO is measured on ground, measures the expiration NO concentration at least one expiratory duration point, it is desirable that testee ensures accurately to measure
Required exhalation flow and pressure and other parameters, the testee that can coordinate this can obtain measurement result quickly；
Allow detected person according to setting flow rates and pass through an expiratory resistance reach standard requirement flow velocity (such as using
Measuring instrumentss or computer demonstration), it can be controlled than the pressure of exhalation and more easily reach required flow, flow is to determine eNO water
Flat principal element；
Wherein under the conditions of single breath, if keep exhalation flow rate it is constant, just can be formed same pattern exhalation NO concentration-when
Between change curve, curve just enters plateau after experience row washes the phase, and plateau has reproducibility, usually very steady, may
Updip has a down dip, and sometimes, row washes the phase and peak value followed by occurs later, when observing object nose or while starting air-breathing is soft
Palate is in open configuration, and the NO in nasal cavity will be formed with upward peak, sucks NO in air or when observation object air-breathing to lung
It is not breathed out in time after total capacity and NO is made to accumulate in oral cavity and lower respiratory tract, can all generate similar phenomenon, this peak value can neglect
Slightly disregard, it is important that the analysis platform phase；
NO curves are divided with 3 seconds (0.15L) for unit, it is assumed that starting point A, terminal B, the AB slope of curve can be zero
Value, positive value or negative value, if AB curves be occur earliest on NO curves, slope absolute value less than 10% and fluctuation range exist
Between three-second area within 10%, then its mean value can be used to represent oral cavity eNO, once obtaining more than mean value, detected person can stop
It only exhales, in oral cavity eNO less than in the case of 10ppb, it is contemplated that the variables such as instrument accuracy of detection and the control of patient's exhalation flow rate
Factor, the operability that 10% NO concentration plateaus weigh principle are poor；It has been generally acknowledged that the fluctuation range of AB curves is in 1ppb
Within can receive, on-line analysis device will be according to more than principle automatic identification NO plateaus, by the expiratory flow of 0.05L/s
Speed, NO plateaus, are usually very gentle, and easily identify；
Expiration program should be repeated at least twice, and to obtain the measured value that two gaps are no more than 10%, their mean value just represents
NO exhalation in oral cavity is horizontal, and in some cases, when such as measuring NO contents with different exhalation flow rates, procedure above preferably obtains three
A effective FENO after every wheel is exhaled, should at least allow detected person to rest 30 seconds, when patient does not feel like oneself not
Carry out duplicate measurements.
2. a kind of Exhaled nitric oxide measuring method for not needing to control expiratory gas flow according to claims 1,
It is characterized in that, the NO outputs represent the amount of the NO in expiratory air, are represented with VNO, calculate the concentration of NO in every liter of expiratory air, single
Position for nanoliter, calculate expiratory gas flow per minute, for unit to rise, calculation formula is as follows：
VNO (nl/minute)=NO (nl/L) ' flows (L/minute).
3. a kind of Exhaled nitric oxide measuring method for not needing to control expiratory gas flow according to claims 1,
It is characterized in that, the plateau generated in NO, instantaneous flow is not less than 0.045L/S, not higher than 0.055L/S, if tested
Person cannot be maintained within the scope of this, then result should be used as and measure failure.
4. a kind of Exhaled nitric oxide measuring method for not needing to control expiratory gas flow according to claims 1,
It is characterized in that, the control expiratory resistance is more than 5cmH2O, and the premise of soft palate is closed described in this ATS standard, on this condition may be used
The interference of upper respiratory tract NO (nasal cavity) is avoided, second is that sustained exhalation total volume, which is more than air flue dead volume, (need not control expiratory flow
Amount),
Described to be breathed out immediately with after oral inhalation, exhalation flow rate is maintained at 0.05L/s, and pressure is maintained at 5-20cm H2O so that soft
Palate is closed, and the time at least keeps four seconds until NO maintenance levels reach 2 seconds or more, for the children of less than 12 years old, expiratory duration
At least four seconds；For the children of 12 years old or more, expiratory duration at least six seconds,
It is described it based on expiration NO gas exchanges two compartment models, reached by measuring in moisture exhalation process the variation of NO concentration
The anti-expiration NO concentration pushed away under standard expiratory gas flow of numerical value during stable state can adjust moisture expiration by changing moisture expiratory resistance
According to multiple expiratory gas flows and corresponding stable state expiration NO concentration, the parameters of expiration NO are solved by numerical algorithm for flow.
5. a kind of Exhaled nitric oxide measuring method for not needing to control expiratory gas flow according to claims 1,
Be characterized in that, it is described rest repeat after 30 seconds it is above inhale expiration program, repeat two to three times, existed with obtaining two to three and fluctuating
Oral cavity FENO stationary values within 10%；Or repeat twice, stablized with obtaining oral cavity FENO of two fluctuations within 5%
Value for the preprimary child for being difficult to reach exhalation flow rate and pressure requirements, can use the supplementary means such as audiovisuals and flow controller,
Audiovisuals can prompt whether air-breathing reaches total lung capacity position, and help to control exhalation flow rate, and flow controller makes children be pressed in oral cavity
Power remains to the exhalation flow rate kept constant in the case of changing.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110833415A (en) * | 2018-08-15 | 2020-02-25 | 深圳市美好创亿医疗科技有限公司 | Expiratory NO detection system |
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