CN110283669A - 一种含np10抗菌肽的绿色抗菌洗洁精及其制备方法和应用 - Google Patents
一种含np10抗菌肽的绿色抗菌洗洁精及其制备方法和应用 Download PDFInfo
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- CN110283669A CN110283669A CN201910548222.XA CN201910548222A CN110283669A CN 110283669 A CN110283669 A CN 110283669A CN 201910548222 A CN201910548222 A CN 201910548222A CN 110283669 A CN110283669 A CN 110283669A
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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Abstract
本发明提供一种含NP10抗菌肽的绿色抗菌洗洁精及其制备方法和应用，属于洗涤液技术领域。绿色抗菌洗洁精包括以下质量百分含量的组分：阴离子表面活性剂14％～20％、非离子表面活性剂4％～12％、NP10抗菌肽0.10％～0.15％、柠檬酸钠0.08％～0.12％、尿素1％～3％、EDTA二钠0.08％～0.12％、山梨醇0.1％～0.3％、维生素E 0.1％～0.3％，余量的水。NP10抗菌肽协同柠檬酸钠，具有增强抑菌性能，再配合阴离子表面活性剂与非离子表面活性剂，能提高去污能力，还具有抗硬水性能。所述洗洁精有出色的去污能力，同时还能够滋润保护皮肤，抗菌肽出色抗菌作用比化学抑菌剂用量更少更健康。
Description
技术领域
本发明属于洗涤液技术领域，具体涉及一种含NP10抗菌肽的绿色抗菌洗洁精及其制备方法和应用。
背景技术
洗洁精为日常消费性用品，洁净温和，泡沫柔细，迅速分解油腻，具有快速去污、除菌的作用，对餐具和果蔬有效清洁。市面常规洗洁精大多单纯靠化学防腐剂杀菌抑菌，难降解，抑菌效果差，对皮肤刺激性大，所以急需一种抗菌能力强，对皮肤无刺激，对身体无副作用的，对环境无伤害的抗菌添加剂。
公开号为CN107523438的专利公开了一种含美洲大蠊活性成分的手洗餐具洗洁精，由表面活性剂40-50％，杀菌成分0.1-0.8％，护肤成分1-3％、美洲大蠊活性成分0.01-1％、柠檬酸钠0.5％、余量的去离子水组成。所述植物提取液作为手洗餐具洗洁精的护肤成分，有防止皮肤干燥成分、皮肤保湿成分，解决手洗餐具后手干燥的现象，既可以护肤，对环境也无压力，易降解。所述洗洁精的杀菌效果和护肤效果较常规洗洁精效果更优异。但是上述洗洁精所需组分提取步骤操作复杂，而且来源不易得，并且杀菌种类和效果也有待丰富和提高。
发明内容
有鉴于此，本发明的目的在于提供一种含NP10抗菌肽的绿色抗菌洗洁精及其制备方法和应用，所述绿色抗菌洗洁精具有抗菌能力强，对皮肤无刺激，对身体无副作用，对环境无伤害的特点。
本发明提供的一种含NP10抗菌肽的绿色抗菌洗洁精，包括以下质量百分含量的组分：阴离子表面活性剂14％～20％、非离子表面活性剂4％～12％、NP10抗菌肽0.10％～0.15％、柠檬酸钠0.08％～0.12％、尿素1％～3％、EDTA二钠0.08％～0.12％、山梨醇0.1％～0.3％、维生素E0.1％～0.3％，水补足至100％。
优选的，包括以下质量百分含量的组分：阴离子表面活性剂18％、非离子表面活性剂8％、NP10抗菌肽0.12％、柠檬酸钠0.1％、尿素2％、EDTA二钠0.1％、山梨醇0.2％、维生素E0.2％，水补足余量至100％。
优选的，所述阴离子表面活性剂包括月桂酰胺丙基甜菜碱、十二烷基苯磺酸钠、α-烯基磺酸钠、脂肪醇聚氧乙烯醚硫酸钠和月桂醇硫酸钠中的两种或多种。
优选的，按绿色抗菌洗洁精的总质量为100％计，所述阴离子表面活性剂包括质量百分含量6％～8％十二烷基苯磺酸钠和质量百分含量8％～12％脂肪醇聚氧乙烯醚硫酸钠。
优选的，所述非离子表面活性剂包括醇醚硫酸钠、烷基醇酰胺、腰果酚聚乙烯醚、月桂酰胺丙基氧化胺、椰油乙二醇酰胺、烷基糖苷和聚乙烯吡咯烷酮中的两种或多种。
优选的，按绿色抗菌洗洁精的总质量为100％计，所述非离子表面活性剂包括质量百分含量3％～9％烷基糖苷和质量百分含量1％～3％聚乙烯吡咯烷酮。
优选的，所述烷基糖苷包括C8～C10的烷基糖苷。
本发明提供的所述的绿色抗菌洗洁精的制备方法，包括以下步骤：
1)将NP10抗菌肽溶解于水中，得到A溶液；
2)将阴离子表面活性剂和非离子表面活性剂在水浴条件下与水混合溶解，得到B溶液；
3)将尿素和水混合溶解，得到C溶液；
4)将所述C溶液与柠檬酸钠、EDTA二钠、山梨醇和维生素E混合溶解，调节所得混合液的pH值至中性，得到D溶液；
5)将所述D溶液与所述A溶液、B溶液和C溶液混合，得到绿色抗菌洗洁精；其中步骤1)～4)之间没有时间顺序的限制。
优选的，步骤2)中所述水浴的温度为38～42℃。
本发明提供了所述的绿色抗菌洗洁精或所述制备方法制备得到的绿色抗菌洗洁精在洗涤杀菌中的应用。
本发明提供的一种含NP10抗菌肽的绿色抗菌洗洁精，包括以下质量百分含量的组分：阴离子表面活性剂14％～20％、非离子表面活性剂4％～12％、NP10抗菌肽0.10％～0.15％、柠檬酸钠0.08％～0.12％、尿素1％～3％、EDTA二钠0.08％～0.12％、山梨醇0.1％～0.3％、维生素E0.1％～0.3％，水补足至100％。本发明是以NP10抗菌肽为核心抑菌组分，NP10抗菌肽抗菌谱广，对临床常见的金黄色葡萄球菌如VRSA、MRSA，以及多重耐药的绿脓杆菌、耐药的沙门氏菌、大肠杆菌、金黄色葡萄球菌、肺炎链球菌、鲍曼不动杆菌、艰难梭菌、阪崎肠杆菌、肠球菌、阴沟肠杆菌、牙龈卟啉单胞菌、变异链球菌、痤疮丙酸杆菌、芽孢杆菌、支原体等以及常见真菌的抗菌：包括白色念珠菌、马拉色菌、须廯毛廯菌、絮状表皮癣菌、红色毛廯菌、犬小孢子菌、石膏样小孢子菌等15种皮肤廯症的病原真菌具有显著的抗菌效果；同时NP10抗菌肽可快速消炎止痛、对过敏性皮肤和损伤皮肤具有显著的保护和促进修复的作用。所述洗洁精中还包括性质温和、易降解的阴离子表面活性剂和非离子表面活性剂，阴离子表面活性剂与非离子表面活性剂与NP10抗菌肽联合使用，不但能提高去污能力，而且具有抗硬水性能。以NP10抗菌肽搭配柠檬酸钠协同杀菌，效果显著。同时洗洁精中还包括尿素和EDTA二钠，增加透明性、溶解性、有很少的增粘性，对洗涤有助洗作用，加强无机污垢的溶解性。山梨醇和维生素E作为护肤成分，使用洗洁精后对手皮肤具有滋润功能，降低对手皮肤的损害。
附图说明
图1为本发明提供的洗洁精制备步骤流程图；
图2为本发明提供的NP10抗菌肽的生物制备流程图。
具体实施方式
本发明提供的一种含NP10抗菌肽的绿色抗菌洗洁精，包括以下质量百分含量的组分：阴离子表面活性剂14％～20％、非离子表面活性剂4％～12％、NP10抗菌肽0.10％～0.15％、柠檬酸钠0.08％～0.12％、尿素1％～3％、EDTA二钠0.08％～0.12％、山梨醇0.1％～0.3％、维生素E0.1％～0.3％，水补足至100％。
本发明提供的绿色抗菌洗洁精包括阴离子表面活性剂。按以绿色抗菌洗洁精的质量百分含量为100％计，所述阴离子表面活性剂包括14％～20％，优选为18％。所述阴离子表面活性剂优选包括月桂酰胺丙基甜菜碱、十二烷基苯磺酸钠、α-烯基磺酸钠、脂肪醇聚氧乙烯醚硫酸钠和月桂醇硫酸钠中的两种或多种。所述阴离子表面活性剂更优选包括质量百分含量6％～8％十二烷基苯磺酸钠和质量百分含量8％～12％脂肪醇聚氧乙烯醚硫酸钠。本发明对所述阴离子表面活性剂的来源没有特殊限制，采用本领域所熟知的阴离子表面活性剂即可。
本发明提供的绿色抗菌洗洁精包括非离子表面活性剂。按以绿色抗菌洗洁精的质量百分含量为100％计，所述非离子表面活性剂为4％～12％，优选为8％。所述非离子表面活性剂优选包括醇醚硫酸钠、烷基醇酰胺、腰果酚聚乙烯醚、月桂酰胺丙基氧化胺、椰油乙二醇酰胺、烷基糖苷和聚乙烯吡咯烷酮中的两种或多种。按绿色抗菌洗洁精的总质量为100％计，所述非离子表面活性剂更优选包括质量百分含量3％～9％烷基糖苷和质量百分含量1％～3％聚乙烯吡咯烷酮。所述烷基糖苷包括C8～C10的烷基糖苷，例如壬基烷基糖苷或辛基烷基糖苷。本发明对所述非离子表面活性剂的来源没有特殊限制，采用本领域所熟知的阴离子表面活性剂即可。在本发明中，将阴离子表面活性剂与非离子表面活性剂联合使用，不但能提高去污能力，而且具有抗硬水性能。
本发明提供的绿色抗菌洗洁精包括NP10抗菌肽。按以绿色抗菌洗洁精的质量百分含量为100％计，所述NP10抗菌肽为0.10％～0.15％，优选为0.12％。所述NP10抗菌肽具有抗菌谱广的特点，包括细菌和真菌。所述细菌包括临床常见的金黄色葡萄球菌如VRSA、MRSA，多重耐药的绿脓杆菌、耐药的沙门氏菌、大肠杆菌、金黄色葡萄球菌、肺炎链球菌、鲍曼不动杆菌、艰难梭菌、阪崎肠杆菌、肠球菌、阴沟肠杆菌、牙龈卟啉单胞菌、变异链球菌、痤疮丙酸杆菌、芽孢杆菌、支原体等。所述真菌的包括白色念珠菌、马拉色菌、须廯毛廯菌、絮状表皮癣菌、红色毛廯菌、犬小孢子菌、石膏样小孢子菌等15种皮肤廯症的病原真菌。此外NP10抗菌肽拥有独特的杀菌机制可快速消炎止痛、对过敏性皮肤和损伤皮肤具有显著的保护和促进修复的作用。另外，所述NP10抗菌肽与常见抗生素的杀菌作用有很大差别，具体区别如下：<1>杀菌机制不同：特异性地作用于有害细菌类的细胞壁，通过阴阳离子的静电结合来改变细胞壁的通透性，最终导致细胞死亡。传统抗生素大多是通过抑制细菌细胞壁或DNA的合成而发挥作用，作用靶点通常是单一的个体或者族群(如青霉素结合蛋白、拓扑异构酶等)。舒口汰TM抗菌爽口液既可以独立地作用于细胞壁来破坏细胞而发挥其杀菌、抗菌作用，也可以与其他因子协同作用，从而发挥更高的效率。它不但能与传统抗生素协同作用，也能与乳铁蛋白和溶菌酶等相互作用以提高抗菌及杀菌效果。<2>产生耐药性的速度不同：所述抗菌肽是针对广谱有害菌类的细胞壁，并不涉及特定的靶点，它直接通过静电作用来破坏细胞，因此可以迅速杀死有害细菌和微生物。由于细菌表面的结构和带电性无法改变，所以很难产生抗药性。再加上它能被体内蛋白酶及时水解，其半衰期也比传统抗生素要短。相反，传统抗生素的作用涉及到细菌细胞壁或细胞内特异的靶点，由于靶点类型有限，细菌很容易通过变异而产生耐药性。<3>作用速度不同：所述抗菌肽直接作用于有害细菌的细胞膜，它最大的优点就在于作用迅速并具有很高的杀伤力。而传统抗生素则通过作用于增殖的细菌中的某些部位起到抑菌作用，其作用时间往往需要几天。<4>针对性不同：抗生素主要是针对特有细菌起抗菌作用，而本品则针对广谱的有害细菌及微生物来实施抗菌及杀菌的多重生物功能。最后是关于安全性分析，所述抗菌肽是由氨基酸排列组合成的多肽，经由生物酶发酵而成，不含抗生素、酒精、中药和化药，所以不会产生抗药性，无毒副作用，使用后可分解为人体自身营养成分-氨基酸，天然安全见效快。所述NP10抗菌肽的构建方法见图2。所述NP10抗菌肽购自纳肽得(青岛)生物医药有限公司。
本发明提供的绿色抗菌洗洁精包括柠檬酸钠。按以绿色抗菌洗洁精的质量百分含量为100％计，所述柠檬酸钠为0.08％～0.12％，优选为0.1％。所述柠檬酸钠与NP10抗菌肽搭配协同杀菌，效果显著。同时所述柠檬酸钠用于调整洗洁精的pH值。用柠檬酸钠调整pH至7～7.5时，有利于保持NP10抗菌肽最好的抗菌活性。本发明对所述柠檬酸钠的来源没有特殊限制，采用本领域所熟知的柠檬酸钠的来源即可。
本发明提供的绿色抗菌洗洁精包括尿素。按以绿色抗菌洗洁精的质量百分含量为100％计，所述尿素为1％～3％，优选为2％。尿素有利于增加透明性、溶解性、有很少的增粘性，对洗涤有少许的助洗作用，加强无机污垢的溶解性。本发明对所述尿素的来源没有特殊限制，采用本领域所熟知的尿素来源即可。
本发明提供的绿色抗菌洗洁精包括EDTA二钠。按以绿色抗菌洗洁精的质量百分含量为100％计，所述EDTA二钠为0.08％～0.12％，优选为0.1％。所述EDTA二钠作为助洗剂，有利于增加透明性、溶解性、有很少的增粘性，对洗涤有少许的助洗作用，加强无机污垢的溶解性。本发明对所述EDTA二钠的来源没有特殊限制，采用本领域所熟知的EDTA二钠来源即可。
本发明提供的绿色抗菌洗洁精包括山梨醇。按以绿色抗菌洗洁精的质量百分含量为100％计，所述山梨醇为0.1％～0.3％，优选为0.2％。所述山梨醇作为护肤剂，有利于保护皮肤免受刺激。本发明对所述山梨醇的来源没有特殊限制，采用本领域所熟知的山梨醇的来源即可。
本发明提供的绿色抗菌洗洁精包括维生素E。按以绿色抗菌洗洁精的质量百分含量为100％计，所述维生素E为0.1％～0.3％。优选为0.2％。所述维生素E作为护肤剂，有利于保护皮肤免受刺激。本发明对所述维生素E的来源没有特殊限制，采用本领域所熟知的维生素E的来源即可。
本发明提供的绿色抗菌洗洁精包括水。水作为溶剂起到分散作用。所述水优选为去离子水。用水补足余量至100％。
本发明提供的所述的绿色抗菌洗洁精的制备方法，包括以下步骤：
1)将NP10抗菌肽溶解于水中，得到A溶液；
2)将阴离子表面活性剂和非离子表面活性剂在水浴条件下与水混合溶解，得到B溶液；
3)将尿素和水混合溶解，得到C溶液；
4)将所述C溶液与柠檬酸钠、EDTA二钠、山梨醇和维生素E混合溶解，调节所得混合液的pH值至中性，得到D溶液；
5)将所述D溶液与所述A溶液、B溶液和C溶液混合，得到绿色抗菌洗洁精；其中步骤1)～4)之间没有时间顺序的限制。
本发明对所述混合的方法没有特殊限制，采用本领域所熟知的混合方案即可。所述水浴的温度优选为38～42℃，更优选为40℃。调节所得混合液的pH值用试剂为柠檬酸钠。
本发明提供了所述的绿色抗菌洗洁精或所述制备方法制备得到的绿色抗菌洗洁精在洗涤杀菌中的应用。
在本发明中，所述绿色抗菌洗洁精的使用方法和使用量没有特殊限制，采用本领域所熟知的使用方法及使用量即可。本发明对所述洗涤杀菌的适用对象没有特殊限制，例如餐具、果蔬或手部等均可适用。
下面结合实施例对本发明提供的一种含NP10抗菌肽的绿色抗菌洗洁精及其制备方法和应用进行详细的说明，但是不能把它们理解为对本发明保护范围的限定。
实施例1
绿色洗洁精的组分：十二烷基苯磺酸钠6％，脂肪醇聚氧乙烯醚硫酸钠10％，烷基糖苷6％，聚乙烯吡咯烷酮2％，NP10抗菌肽0.1％，柠檬酸钠0.1％，尿素1％，EDTA二钠0.1％，维生素E0.3％，山梨醇0.1％，去离子水补足余量至100％。
绿色洗洁精的制备方法如下：
a.室温下精密称取0.1g抗菌肽粉末溶于10ml蒸馏水中，得到溶液A；
b.6g十二烷基苯磺酸钠和10ml水混合，形成十二烷基苯磺酸钠溶液；将10g脂肪醇聚氧乙烯醚硫酸钠、6g烷基糖苷和2g聚乙烯吡咯烷酮添加到30ml的水中，再与十二烷基苯磺酸钠溶液混合，混合液在40℃的水浴中加热搅拌，搅拌至澄清透明，得到溶液B；
c.将1g尿素加入10ml蒸馏水中待溶解，得到溶液C；
d.向溶液C中加入0.1gEDTA二钠、0.1g山梨醇、0.3g维生素E，溶解后得到溶液D，用柠檬酸钠调节pH值至中性，得到溶液D；
e.将溶液D与溶液A混合，定容至100ml，得到成品。
实施例2
绿色洗洁精的组分：月桂酰胺丙基甜菜碱6％，α-烯基磺酸钠10％，月桂酰胺丙基氧化胺6％，椰油乙二醇酰胺2％，NP10抗菌肽0.12％，柠檬酸钠0.1％，尿素1％，EDTA二钠0.1％，维生素E0.3％，山梨醇0.1％，去离子水补足余量至100％。
绿色洗洁精的制备方法如下：
a.室温下精密称取0.12g抗菌肽粉末溶于10ml蒸馏水中，得到溶液A；
b.将6g月桂酰胺丙基甜菜碱、10gα-烯基磺酸钠、6g月桂酰胺丙基氧化胺和2g椰油乙二醇酰胺在40℃的水浴中添加到40ml的水中加热搅拌，搅拌至澄清透明，得到溶液B；
c.将1g尿素加入10ml蒸馏水中待溶解，得到溶液C；
d.向溶液C中加入0.1gEDTA二钠、0.1g山梨醇、0.3g维生素E，溶解后得到溶液D，用柠檬酸钠调节pH值至中性，得到溶液D；
e.将溶液D与溶液A混合，定容至100ml，得到成品。
实施例3
绿色洗洁精的组分：十二烷基苯磺酸钠8％，脂肪醇聚氧乙烯醚硫酸钠12％，烷基糖苷5％，聚乙烯吡咯烷酮1％，NP10抗菌肽0.15％，柠檬酸钠0.1％，尿素1％，EDTA二钠0.1％，维生素E0.3％，山梨醇0.1％，去离子水补足余量至100％。
绿色洗洁精的制备方法如下：
a.室温下精密称取0.15g抗菌肽粉末溶于10ml蒸馏水中，得到溶液A；
b.将8g十二烷基苯磺酸钠和10ml水混合，形成十二烷基苯磺酸钠溶液；将12g脂肪醇聚氧乙烯醚硫酸钠、5g烷基糖苷和1g聚乙烯吡咯烷酮添加到30ml的水中，再与十二烷基苯磺酸钠溶液混合，得到的混合液在40℃的水浴中加热搅拌，搅拌至澄清透明，得到溶液B；
c.将1g尿素加入10ml蒸馏水中待溶解，得到溶液C；
d.向溶液C中加入0.1gEDTA二钠、0.1g山梨醇、0.3g维生素E，溶解后得到溶液D，用柠檬酸钠调节pH值至中性，得到溶液D；
e.将溶液D与溶液A混合，定容至100ml，得到成品。
对比例1
各成分的重量百分比为：十二烷基苯磺酸6％，脂肪醇聚氧乙烯醚硫酸钠10％，烷基糖苷6％，NP10抗菌肽0.1％，柠檬酸钠0.1％，氢氧化钠0.1％，尿素1％，EDTA二钠0.1％，维生素E0.3％，山梨醇0.1％，去离子水补足余量至100％。制备方法同实施例1。
对比例2
参见申请号为CN201210262175.0的专利，具体方案如下：各成分的重量百分比为：磺酸10％，水6％，NP10抗菌肽0.1％，乙醇10％，AES10％，650115％,无水焦磷酸钠5％，纯碱9％，硫酸镁2％，卡松2％，非离子表面活性剂1％，香精9％，液态皂6％，无水磺酸钠9％，片碱3％，香料3％。
对比例3
绿色洗洁精的组分：十二烷基苯磺酸8％，脂肪醇聚氧乙烯醚硫酸钠12％，NP10抗菌肽0.15％，柠檬酸钠0.1％，尿素1％，EDTA二钠0.1％，维生素E0.3％，山梨醇0.1％，去离子水补足余量至100％。
绿色洗洁精的制备方法如下：
a.室温下精密称取0.15g抗菌肽粉末溶于10ml蒸馏水中，得到溶液A；
b.将8g十二烷基苯磺酸和10ml水混合，用氢氧化钠中和pH值至7～7.5，形成十二烷基苯磺酸钠溶液；12g脂肪醇聚氧乙烯醚硫酸钠添加到30ml的水中，再与十二烷基苯磺酸钠溶液混合，所得混合液在40℃的水浴中加热搅拌，搅拌至澄清透明，得到溶液B；
c.将1g尿素加入10ml蒸馏水中待溶解，得到溶液C；
d.向溶液C中加入0.1gEDTA二钠、0.1g山梨醇、0.3g维生素E，溶解后得到溶液D，用柠檬酸钠调节pH值至中性，得到溶液D；
e.将溶液D与溶液A混合，定容至100ml，得到成品。
实施例4
抗菌实验
一、实验方法
a.大肠杆菌、金黄色葡萄球菌分别接种到6mlTSB培养基中，35℃孵育20h；白色念珠菌接种到6mlTSB培养基中，27℃孵育48h采用TTC法测定抑菌率。
b.用新鲜的TSB将大肠杆菌、金黄色葡萄球菌、白色念珠菌稀释至浓度为1×108CFU/ml(取过夜培养好的菌液1μl，加入25mlTSB中，用枪吹匀)，加入到96孔板中，每孔50μl，取用TSB培养基稀释至目的浓度的药液50μl加入菌液中，每孔共100μl，大肠杆菌、金黄色葡萄球菌孵育20h，白色念珠菌孵育48h后用酶标仪在532nm处测吸光值，计算抑菌率。
二、实验分组
A.实验组1，为实施例1制备的含NP10抗菌肽的绿色抗菌洗洁精；
B.阳性对照组，为对比例1制备的不含NP10抗菌肽的绿色抗菌洗洁精；
C.阳性对照组，为对比例2制备的含磺酸和NP10抗菌肽的洗洁精；
D.实验组2，为实施例2制备的含NP10抗菌肽的绿色抗菌洗洁精；
E.实验组3，为实施例3制备的含NP10抗菌肽的绿色抗菌洗洁精；
F.阳性对照组，为对比例3制备的仅含有阴离子表面活性剂和NP10抗菌肽的洗洁精。
三、实验结果:
表1不同组别的洗洁精抑菌率结果
| A | B | C | D | E | F | |
| 大肠杆菌 | 70.10％ | 44.70％ | 52.70％ | 69.40％ | 79.10％ | 49.10％ |
| 金黄色葡萄球菌 | 65.00％ | 49.80％ | 47.40％ | 65.60％ | 77.00％ | 48.40％ |
| 白色念珠菌 | 62.00％ | 40.20％ | 45.60％ | 60.20％ | 75.50％ | 44.00％ |
由表1可知，本发明提供的绿色抗菌洗洁精比三组阳性对照的抑菌率均高，说明本发明的方案中NP10抗菌肽为抑菌核心组分，同时阴离子表面活性剂和非离子表面活性剂协同作用，同时阴离子表面活性剂和非离子表面活性剂替换磺酸对提高洗洁精的抑菌性具有显著效果。
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。
Claims (10)
1.一种含NP10抗菌肽的绿色抗菌洗洁精，其特征在于，包括以下质量百分含量的组分：阴离子表面活性剂14％～20％、非离子表面活性剂4％～12％、NP10抗菌肽0.10％～0.15％、柠檬酸钠0.08％～0.12％、尿素1％～3％、EDTA二钠0.08％～0.12％、山梨醇0.1％～0.3％、维生素E0.1％～0.3％，水补充至100％。
2.根据权利要求1所述的绿色抗菌洗洁精，其特征在于，包括以下质量百分含量的组分：阴离子表面活性剂18％、非离子表面活性剂8％、NP10抗菌肽0.12％、柠檬酸钠0.1％、尿素2％、EDTA二钠0.1％、山梨醇0.2％、维生素E0.2％，水补足余量至100％。
3.根据权利要求1或2所述的绿色抗菌洗洁精，其特征在于，所述阴离子表面活性剂包括月桂酰胺丙基甜菜碱、十二烷基苯磺酸钠、α-烯基磺酸钠、脂肪醇聚氧乙烯醚硫酸钠和月桂醇硫酸钠中的两种或多种。
4.根据权利要求3所述的绿色抗菌洗洁精，其特征在于，按绿色抗菌洗洁精的总质量为100％计，所述阴离子表面活性剂包括质量百分含量6％～8％十二烷基苯磺酸钠和质量百分含量8％～12％脂肪醇聚氧乙烯醚硫酸钠。
5.根据权利要求1或2所述的绿色抗菌洗洁精，其特征在于，所述非离子表面活性剂包括醇醚硫酸钠、烷基醇酰胺、腰果酚聚乙烯醚、月桂酰胺丙基氧化胺、椰油乙二醇酰胺、烷基糖苷和聚乙烯吡咯烷酮中的两种或多种。
6.根据权利要求5所述的绿色抗菌洗洁精，其特征在于，按绿色抗菌洗洁精的总质量为100％计，所述非离子表面活性剂包括质量百分含量3％～9％烷基糖苷和质量百分含量1％～3％聚乙烯吡咯烷酮。
7.根据权利要求6所述的绿色抗菌洗洁精，其特征在于，所述烷基糖苷包括C8～C10的烷基糖苷。
8.权利要求1～7任意一项所述的绿色抗菌洗洁精的制备方法，其特征在于，包括以下步骤：
1)将NP10抗菌肽溶解于水中，得到A溶液；
2)将阴离子表面活性剂和非离子表面活性剂在水浴条件下与水混合溶解，得到B溶液；
3)将尿素和水混合溶解，得到C溶液；
4)将所述C溶液与柠檬酸钠、EDTA二钠、山梨醇和维生素E混合溶解，调节所得混合液的pH值至中性，得到D溶液；
5)将所述D溶液与所述A溶液、B溶液和C溶液混合，得到绿色抗菌洗洁精；其中步骤1)～4)之间没有时间顺序的限制。
9.根据权利要求8所述的制备方法，其特征在于，步骤2)中所述水浴的温度为38～42℃。
10.权利要求1～7任意一项所述的绿色抗菌洗洁精或权利要求8或9所述制备方法制备得到的绿色抗菌洗洁精在洗涤杀菌中的应用。
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