CN110283669A - 一种含np10抗菌肽的绿色抗菌洗洁精及其制备方法和应用 - Google Patents
一种含np10抗菌肽的绿色抗菌洗洁精及其制备方法和应用 Download PDFInfo
- Publication number
- CN110283669A CN110283669A CN201910548222.XA CN201910548222A CN110283669A CN 110283669 A CN110283669 A CN 110283669A CN 201910548222 A CN201910548222 A CN 201910548222A CN 110283669 A CN110283669 A CN 110283669A
- Authority
- CN
- China
- Prior art keywords
- solution
- cleanser essence
- antibacterial peptide
- green
- antimicrobial cleanser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 56
- 239000003910 polypeptide antibiotic agent Substances 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 46
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 46
- 239000001509 sodium citrate Substances 0.000 claims abstract description 30
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 30
- 239000003945 anionic surfactant Substances 0.000 claims abstract description 26
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000004202 carbamide Substances 0.000 claims abstract description 24
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 24
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 23
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 23
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 23
- 229940046009 vitamin E Drugs 0.000 claims abstract description 23
- 239000011709 vitamin E Substances 0.000 claims abstract description 23
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims abstract description 21
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 28
- -1 olefin sulfonate Chemical class 0.000 claims description 22
- 229930182470 glycoside Natural products 0.000 claims description 15
- 238000004090 dissolution Methods 0.000 claims description 13
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- 150000002191 fatty alcohols Chemical class 0.000 claims description 12
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 11
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 11
- 235000011152 sodium sulphate Nutrition 0.000 claims description 11
- ILRSCQWREDREME-UHFFFAOYSA-N dodecanamide Chemical compound CCCCCCCCCCCC(N)=O ILRSCQWREDREME-UHFFFAOYSA-N 0.000 claims description 10
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 10
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 claims description 10
- 239000011734 sodium Substances 0.000 claims description 9
- 229910052708 sodium Inorganic materials 0.000 claims description 9
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 238000004659 sterilization and disinfection Methods 0.000 claims description 7
- 238000005406 washing Methods 0.000 claims description 7
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 5
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims description 5
- 229930182478 glucoside Natural products 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims description 3
- 229940043264 dodecyl sulfate Drugs 0.000 claims description 3
- 229920001289 polyvinyl ether Polymers 0.000 claims description 3
- 238000012163 sequencing technique Methods 0.000 claims description 3
- 150000008131 glucosides Chemical class 0.000 claims description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract description 27
- 238000004851 dishwashing Methods 0.000 abstract description 26
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 23
- 239000000126 substance Substances 0.000 abstract description 4
- 239000008233 hard water Substances 0.000 abstract description 3
- 238000004140 cleaning Methods 0.000 abstract description 2
- 239000000022 bacteriostatic agent Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 59
- 241000894006 Bacteria Species 0.000 description 21
- 230000003115 biocidal effect Effects 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 239000000306 component Substances 0.000 description 8
- 239000012153 distilled water Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 241000191967 Staphylococcus aureus Species 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 241000588724 Escherichia coli Species 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000009471 action Effects 0.000 description 6
- 210000002421 cell wall Anatomy 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 239000008367 deionised water Substances 0.000 description 6
- 229910021641 deionized water Inorganic materials 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 241000222122 Candida albicans Species 0.000 description 5
- 241000233866 Fungi Species 0.000 description 5
- 229940095731 candida albicans Drugs 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 4
- 206010059866 Drug resistance Diseases 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- WBIQQQGBSDOWNP-UHFFFAOYSA-N 2-dodecylbenzenesulfonic acid Chemical compound CCCCCCCCCCCCC1=CC=CC=C1S(O)(=O)=O WBIQQQGBSDOWNP-UHFFFAOYSA-N 0.000 description 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 229940060296 dodecylbenzenesulfonic acid Drugs 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 241000193163 Clostridioides difficile Species 0.000 description 2
- 241000588697 Enterobacter cloacae Species 0.000 description 2
- 241000194033 Enterococcus Species 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 241000893980 Microsporum canis Species 0.000 description 2
- 241000893976 Nannizzia gypsea Species 0.000 description 2
- 241000238675 Periplaneta americana Species 0.000 description 2
- 241000605862 Porphyromonas gingivalis Species 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 206010041925 Staphylococcal infections Diseases 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- 201000005010 Streptococcus pneumonia Diseases 0.000 description 2
- 241000193998 Streptococcus pneumoniae Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000012055 fruits and vegetables Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- YFDKVXNMRLLVSL-UHFFFAOYSA-N 2-dodecylbenzenesulfonic acid;sodium Chemical compound [Na].CCCCCCCCCCCCC1=CC=CC=C1S(O)(=O)=O YFDKVXNMRLLVSL-UHFFFAOYSA-N 0.000 description 1
- QYYMDNHUJFIDDQ-UHFFFAOYSA-N 5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one Chemical compound CN1SC=CC1=O.CN1SC(Cl)=CC1=O QYYMDNHUJFIDDQ-UHFFFAOYSA-N 0.000 description 1
- 241000589291 Acinetobacter Species 0.000 description 1
- 241000588624 Acinetobacter calcoaceticus Species 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241001135265 Cronobacter sakazakii Species 0.000 description 1
- 241000186427 Cutibacterium acnes Species 0.000 description 1
- 101710116957 D-alanyl-D-alanine carboxypeptidase Proteins 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 241001480035 Epidermophyton Species 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 102100032241 Lactotransferrin Human genes 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 241000186429 Propionibacterium Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000223229 Trichophyton rubrum Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 150000004996 alkyl benzenes Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000008358 core component Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- MGEVERFRGPRYII-UHFFFAOYSA-L disodium oxirane sulfate Chemical compound S(=O)(=O)([O-])[O-].[Na+].C1CO1.[Na+] MGEVERFRGPRYII-UHFFFAOYSA-L 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 229940021414 skin shield Drugs 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/83—Mixtures of non-ionic with anionic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
- C11D1/94—Mixtures with anionic, cationic or non-ionic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2065—Polyhydric alcohols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2086—Hydroxy carboxylic acids-salts thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2096—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/32—Amides; Substituted amides
- C11D3/323—Amides; Substituted amides urea or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/33—Amino carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3719—Polyamides or polyimides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3769—(Co)polymerised monomers containing nitrogen, e.g. carbonamides, nitriles or amines
- C11D3/3776—Heterocyclic compounds, e.g. lactam
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/14—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aliphatic hydrocarbons or mono-alcohols
- C11D1/143—Sulfonic acid esters
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/22—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/29—Sulfates of polyoxyalkylene ethers
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/662—Carbohydrates or derivatives
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/75—Amino oxides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Detergent Compositions (AREA)
Abstract
本发明提供一种含NP10抗菌肽的绿色抗菌洗洁精及其制备方法和应用,属于洗涤液技术领域。绿色抗菌洗洁精包括以下质量百分含量的组分:阴离子表面活性剂14%~20%、非离子表面活性剂4%~12%、NP10抗菌肽0.10%~0.15%、柠檬酸钠0.08%~0.12%、尿素1%~3%、EDTA二钠0.08%~0.12%、山梨醇0.1%~0.3%、维生素E 0.1%~0.3%,余量的水。NP10抗菌肽协同柠檬酸钠,具有增强抑菌性能,再配合阴离子表面活性剂与非离子表面活性剂,能提高去污能力,还具有抗硬水性能。所述洗洁精有出色的去污能力,同时还能够滋润保护皮肤,抗菌肽出色抗菌作用比化学抑菌剂用量更少更健康。
Description
技术领域
本发明属于洗涤液技术领域,具体涉及一种含NP10抗菌肽的绿色抗菌洗洁精及其制备方法和应用。
背景技术
洗洁精为日常消费性用品,洁净温和,泡沫柔细,迅速分解油腻,具有快速去污、除菌的作用,对餐具和果蔬有效清洁。市面常规洗洁精大多单纯靠化学防腐剂杀菌抑菌,难降解,抑菌效果差,对皮肤刺激性大,所以急需一种抗菌能力强,对皮肤无刺激,对身体无副作用的,对环境无伤害的抗菌添加剂。
公开号为CN107523438的专利公开了一种含美洲大蠊活性成分的手洗餐具洗洁精,由表面活性剂40-50%,杀菌成分0.1-0.8%,护肤成分1-3%、美洲大蠊活性成分0.01-1%、柠檬酸钠0.5%、余量的去离子水组成。所述植物提取液作为手洗餐具洗洁精的护肤成分,有防止皮肤干燥成分、皮肤保湿成分,解决手洗餐具后手干燥的现象,既可以护肤,对环境也无压力,易降解。所述洗洁精的杀菌效果和护肤效果较常规洗洁精效果更优异。但是上述洗洁精所需组分提取步骤操作复杂,而且来源不易得,并且杀菌种类和效果也有待丰富和提高。
发明内容
有鉴于此,本发明的目的在于提供一种含NP10抗菌肽的绿色抗菌洗洁精及其制备方法和应用,所述绿色抗菌洗洁精具有抗菌能力强,对皮肤无刺激,对身体无副作用,对环境无伤害的特点。
本发明提供的一种含NP10抗菌肽的绿色抗菌洗洁精,包括以下质量百分含量的组分:阴离子表面活性剂14%~20%、非离子表面活性剂4%~12%、NP10抗菌肽0.10%~0.15%、柠檬酸钠0.08%~0.12%、尿素1%~3%、EDTA二钠0.08%~0.12%、山梨醇0.1%~0.3%、维生素E0.1%~0.3%,水补足至100%。
优选的,包括以下质量百分含量的组分:阴离子表面活性剂18%、非离子表面活性剂8%、NP10抗菌肽0.12%、柠檬酸钠0.1%、尿素2%、EDTA二钠0.1%、山梨醇0.2%、维生素E0.2%,水补足余量至100%。
优选的,所述阴离子表面活性剂包括月桂酰胺丙基甜菜碱、十二烷基苯磺酸钠、α-烯基磺酸钠、脂肪醇聚氧乙烯醚硫酸钠和月桂醇硫酸钠中的两种或多种。
优选的,按绿色抗菌洗洁精的总质量为100%计,所述阴离子表面活性剂包括质量百分含量6%~8%十二烷基苯磺酸钠和质量百分含量8%~12%脂肪醇聚氧乙烯醚硫酸钠。
优选的,所述非离子表面活性剂包括醇醚硫酸钠、烷基醇酰胺、腰果酚聚乙烯醚、月桂酰胺丙基氧化胺、椰油乙二醇酰胺、烷基糖苷和聚乙烯吡咯烷酮中的两种或多种。
优选的,按绿色抗菌洗洁精的总质量为100%计,所述非离子表面活性剂包括质量百分含量3%~9%烷基糖苷和质量百分含量1%~3%聚乙烯吡咯烷酮。
优选的,所述烷基糖苷包括C8~C10的烷基糖苷。
本发明提供的所述的绿色抗菌洗洁精的制备方法,包括以下步骤:
1)将NP10抗菌肽溶解于水中,得到A溶液;
2)将阴离子表面活性剂和非离子表面活性剂在水浴条件下与水混合溶解,得到B溶液;
3)将尿素和水混合溶解,得到C溶液;
4)将所述C溶液与柠檬酸钠、EDTA二钠、山梨醇和维生素E混合溶解,调节所得混合液的pH值至中性,得到D溶液;
5)将所述D溶液与所述A溶液、B溶液和C溶液混合,得到绿色抗菌洗洁精;其中步骤1)~4)之间没有时间顺序的限制。
优选的,步骤2)中所述水浴的温度为38~42℃。
本发明提供了所述的绿色抗菌洗洁精或所述制备方法制备得到的绿色抗菌洗洁精在洗涤杀菌中的应用。
本发明提供的一种含NP10抗菌肽的绿色抗菌洗洁精,包括以下质量百分含量的组分:阴离子表面活性剂14%~20%、非离子表面活性剂4%~12%、NP10抗菌肽0.10%~0.15%、柠檬酸钠0.08%~0.12%、尿素1%~3%、EDTA二钠0.08%~0.12%、山梨醇0.1%~0.3%、维生素E0.1%~0.3%,水补足至100%。本发明是以NP10抗菌肽为核心抑菌组分,NP10抗菌肽抗菌谱广,对临床常见的金黄色葡萄球菌如VRSA、MRSA,以及多重耐药的绿脓杆菌、耐药的沙门氏菌、大肠杆菌、金黄色葡萄球菌、肺炎链球菌、鲍曼不动杆菌、艰难梭菌、阪崎肠杆菌、肠球菌、阴沟肠杆菌、牙龈卟啉单胞菌、变异链球菌、痤疮丙酸杆菌、芽孢杆菌、支原体等以及常见真菌的抗菌:包括白色念珠菌、马拉色菌、须廯毛廯菌、絮状表皮癣菌、红色毛廯菌、犬小孢子菌、石膏样小孢子菌等15种皮肤廯症的病原真菌具有显著的抗菌效果;同时NP10抗菌肽可快速消炎止痛、对过敏性皮肤和损伤皮肤具有显著的保护和促进修复的作用。所述洗洁精中还包括性质温和、易降解的阴离子表面活性剂和非离子表面活性剂,阴离子表面活性剂与非离子表面活性剂与NP10抗菌肽联合使用,不但能提高去污能力,而且具有抗硬水性能。以NP10抗菌肽搭配柠檬酸钠协同杀菌,效果显著。同时洗洁精中还包括尿素和EDTA二钠,增加透明性、溶解性、有很少的增粘性,对洗涤有助洗作用,加强无机污垢的溶解性。山梨醇和维生素E作为护肤成分,使用洗洁精后对手皮肤具有滋润功能,降低对手皮肤的损害。
附图说明
图1为本发明提供的洗洁精制备步骤流程图;
图2为本发明提供的NP10抗菌肽的生物制备流程图。
具体实施方式
本发明提供的一种含NP10抗菌肽的绿色抗菌洗洁精,包括以下质量百分含量的组分:阴离子表面活性剂14%~20%、非离子表面活性剂4%~12%、NP10抗菌肽0.10%~0.15%、柠檬酸钠0.08%~0.12%、尿素1%~3%、EDTA二钠0.08%~0.12%、山梨醇0.1%~0.3%、维生素E0.1%~0.3%,水补足至100%。
本发明提供的绿色抗菌洗洁精包括阴离子表面活性剂。按以绿色抗菌洗洁精的质量百分含量为100%计,所述阴离子表面活性剂包括14%~20%,优选为18%。所述阴离子表面活性剂优选包括月桂酰胺丙基甜菜碱、十二烷基苯磺酸钠、α-烯基磺酸钠、脂肪醇聚氧乙烯醚硫酸钠和月桂醇硫酸钠中的两种或多种。所述阴离子表面活性剂更优选包括质量百分含量6%~8%十二烷基苯磺酸钠和质量百分含量8%~12%脂肪醇聚氧乙烯醚硫酸钠。本发明对所述阴离子表面活性剂的来源没有特殊限制,采用本领域所熟知的阴离子表面活性剂即可。
本发明提供的绿色抗菌洗洁精包括非离子表面活性剂。按以绿色抗菌洗洁精的质量百分含量为100%计,所述非离子表面活性剂为4%~12%,优选为8%。所述非离子表面活性剂优选包括醇醚硫酸钠、烷基醇酰胺、腰果酚聚乙烯醚、月桂酰胺丙基氧化胺、椰油乙二醇酰胺、烷基糖苷和聚乙烯吡咯烷酮中的两种或多种。按绿色抗菌洗洁精的总质量为100%计,所述非离子表面活性剂更优选包括质量百分含量3%~9%烷基糖苷和质量百分含量1%~3%聚乙烯吡咯烷酮。所述烷基糖苷包括C8~C10的烷基糖苷,例如壬基烷基糖苷或辛基烷基糖苷。本发明对所述非离子表面活性剂的来源没有特殊限制,采用本领域所熟知的阴离子表面活性剂即可。在本发明中,将阴离子表面活性剂与非离子表面活性剂联合使用,不但能提高去污能力,而且具有抗硬水性能。
本发明提供的绿色抗菌洗洁精包括NP10抗菌肽。按以绿色抗菌洗洁精的质量百分含量为100%计,所述NP10抗菌肽为0.10%~0.15%,优选为0.12%。所述NP10抗菌肽具有抗菌谱广的特点,包括细菌和真菌。所述细菌包括临床常见的金黄色葡萄球菌如VRSA、MRSA,多重耐药的绿脓杆菌、耐药的沙门氏菌、大肠杆菌、金黄色葡萄球菌、肺炎链球菌、鲍曼不动杆菌、艰难梭菌、阪崎肠杆菌、肠球菌、阴沟肠杆菌、牙龈卟啉单胞菌、变异链球菌、痤疮丙酸杆菌、芽孢杆菌、支原体等。所述真菌的包括白色念珠菌、马拉色菌、须廯毛廯菌、絮状表皮癣菌、红色毛廯菌、犬小孢子菌、石膏样小孢子菌等15种皮肤廯症的病原真菌。此外NP10抗菌肽拥有独特的杀菌机制可快速消炎止痛、对过敏性皮肤和损伤皮肤具有显著的保护和促进修复的作用。另外,所述NP10抗菌肽与常见抗生素的杀菌作用有很大差别,具体区别如下:<1>杀菌机制不同:特异性地作用于有害细菌类的细胞壁,通过阴阳离子的静电结合来改变细胞壁的通透性,最终导致细胞死亡。传统抗生素大多是通过抑制细菌细胞壁或DNA的合成而发挥作用,作用靶点通常是单一的个体或者族群(如青霉素结合蛋白、拓扑异构酶等)。舒口汰TM抗菌爽口液既可以独立地作用于细胞壁来破坏细胞而发挥其杀菌、抗菌作用,也可以与其他因子协同作用,从而发挥更高的效率。它不但能与传统抗生素协同作用,也能与乳铁蛋白和溶菌酶等相互作用以提高抗菌及杀菌效果。<2>产生耐药性的速度不同:所述抗菌肽是针对广谱有害菌类的细胞壁,并不涉及特定的靶点,它直接通过静电作用来破坏细胞,因此可以迅速杀死有害细菌和微生物。由于细菌表面的结构和带电性无法改变,所以很难产生抗药性。再加上它能被体内蛋白酶及时水解,其半衰期也比传统抗生素要短。相反,传统抗生素的作用涉及到细菌细胞壁或细胞内特异的靶点,由于靶点类型有限,细菌很容易通过变异而产生耐药性。<3>作用速度不同:所述抗菌肽直接作用于有害细菌的细胞膜,它最大的优点就在于作用迅速并具有很高的杀伤力。而传统抗生素则通过作用于增殖的细菌中的某些部位起到抑菌作用,其作用时间往往需要几天。<4>针对性不同:抗生素主要是针对特有细菌起抗菌作用,而本品则针对广谱的有害细菌及微生物来实施抗菌及杀菌的多重生物功能。最后是关于安全性分析,所述抗菌肽是由氨基酸排列组合成的多肽,经由生物酶发酵而成,不含抗生素、酒精、中药和化药,所以不会产生抗药性,无毒副作用,使用后可分解为人体自身营养成分-氨基酸,天然安全见效快。所述NP10抗菌肽的构建方法见图2。所述NP10抗菌肽购自纳肽得(青岛)生物医药有限公司。
本发明提供的绿色抗菌洗洁精包括柠檬酸钠。按以绿色抗菌洗洁精的质量百分含量为100%计,所述柠檬酸钠为0.08%~0.12%,优选为0.1%。所述柠檬酸钠与NP10抗菌肽搭配协同杀菌,效果显著。同时所述柠檬酸钠用于调整洗洁精的pH值。用柠檬酸钠调整pH至7~7.5时,有利于保持NP10抗菌肽最好的抗菌活性。本发明对所述柠檬酸钠的来源没有特殊限制,采用本领域所熟知的柠檬酸钠的来源即可。
本发明提供的绿色抗菌洗洁精包括尿素。按以绿色抗菌洗洁精的质量百分含量为100%计,所述尿素为1%~3%,优选为2%。尿素有利于增加透明性、溶解性、有很少的增粘性,对洗涤有少许的助洗作用,加强无机污垢的溶解性。本发明对所述尿素的来源没有特殊限制,采用本领域所熟知的尿素来源即可。
本发明提供的绿色抗菌洗洁精包括EDTA二钠。按以绿色抗菌洗洁精的质量百分含量为100%计,所述EDTA二钠为0.08%~0.12%,优选为0.1%。所述EDTA二钠作为助洗剂,有利于增加透明性、溶解性、有很少的增粘性,对洗涤有少许的助洗作用,加强无机污垢的溶解性。本发明对所述EDTA二钠的来源没有特殊限制,采用本领域所熟知的EDTA二钠来源即可。
本发明提供的绿色抗菌洗洁精包括山梨醇。按以绿色抗菌洗洁精的质量百分含量为100%计,所述山梨醇为0.1%~0.3%,优选为0.2%。所述山梨醇作为护肤剂,有利于保护皮肤免受刺激。本发明对所述山梨醇的来源没有特殊限制,采用本领域所熟知的山梨醇的来源即可。
本发明提供的绿色抗菌洗洁精包括维生素E。按以绿色抗菌洗洁精的质量百分含量为100%计,所述维生素E为0.1%~0.3%。优选为0.2%。所述维生素E作为护肤剂,有利于保护皮肤免受刺激。本发明对所述维生素E的来源没有特殊限制,采用本领域所熟知的维生素E的来源即可。
本发明提供的绿色抗菌洗洁精包括水。水作为溶剂起到分散作用。所述水优选为去离子水。用水补足余量至100%。
本发明提供的所述的绿色抗菌洗洁精的制备方法,包括以下步骤:
1)将NP10抗菌肽溶解于水中,得到A溶液;
2)将阴离子表面活性剂和非离子表面活性剂在水浴条件下与水混合溶解,得到B溶液;
3)将尿素和水混合溶解,得到C溶液;
4)将所述C溶液与柠檬酸钠、EDTA二钠、山梨醇和维生素E混合溶解,调节所得混合液的pH值至中性,得到D溶液;
5)将所述D溶液与所述A溶液、B溶液和C溶液混合,得到绿色抗菌洗洁精;其中步骤1)~4)之间没有时间顺序的限制。
本发明对所述混合的方法没有特殊限制,采用本领域所熟知的混合方案即可。所述水浴的温度优选为38~42℃,更优选为40℃。调节所得混合液的pH值用试剂为柠檬酸钠。
本发明提供了所述的绿色抗菌洗洁精或所述制备方法制备得到的绿色抗菌洗洁精在洗涤杀菌中的应用。
在本发明中,所述绿色抗菌洗洁精的使用方法和使用量没有特殊限制,采用本领域所熟知的使用方法及使用量即可。本发明对所述洗涤杀菌的适用对象没有特殊限制,例如餐具、果蔬或手部等均可适用。
下面结合实施例对本发明提供的一种含NP10抗菌肽的绿色抗菌洗洁精及其制备方法和应用进行详细的说明,但是不能把它们理解为对本发明保护范围的限定。
实施例1
绿色洗洁精的组分:十二烷基苯磺酸钠6%,脂肪醇聚氧乙烯醚硫酸钠10%,烷基糖苷6%,聚乙烯吡咯烷酮2%,NP10抗菌肽0.1%,柠檬酸钠0.1%,尿素1%,EDTA二钠0.1%,维生素E0.3%,山梨醇0.1%,去离子水补足余量至100%。
绿色洗洁精的制备方法如下:
a.室温下精密称取0.1g抗菌肽粉末溶于10ml蒸馏水中,得到溶液A;
b.6g十二烷基苯磺酸钠和10ml水混合,形成十二烷基苯磺酸钠溶液;将10g脂肪醇聚氧乙烯醚硫酸钠、6g烷基糖苷和2g聚乙烯吡咯烷酮添加到30ml的水中,再与十二烷基苯磺酸钠溶液混合,混合液在40℃的水浴中加热搅拌,搅拌至澄清透明,得到溶液B;
c.将1g尿素加入10ml蒸馏水中待溶解,得到溶液C;
d.向溶液C中加入0.1gEDTA二钠、0.1g山梨醇、0.3g维生素E,溶解后得到溶液D,用柠檬酸钠调节pH值至中性,得到溶液D;
e.将溶液D与溶液A混合,定容至100ml,得到成品。
实施例2
绿色洗洁精的组分:月桂酰胺丙基甜菜碱6%,α-烯基磺酸钠10%,月桂酰胺丙基氧化胺6%,椰油乙二醇酰胺2%,NP10抗菌肽0.12%,柠檬酸钠0.1%,尿素1%,EDTA二钠0.1%,维生素E0.3%,山梨醇0.1%,去离子水补足余量至100%。
绿色洗洁精的制备方法如下:
a.室温下精密称取0.12g抗菌肽粉末溶于10ml蒸馏水中,得到溶液A;
b.将6g月桂酰胺丙基甜菜碱、10gα-烯基磺酸钠、6g月桂酰胺丙基氧化胺和2g椰油乙二醇酰胺在40℃的水浴中添加到40ml的水中加热搅拌,搅拌至澄清透明,得到溶液B;
c.将1g尿素加入10ml蒸馏水中待溶解,得到溶液C;
d.向溶液C中加入0.1gEDTA二钠、0.1g山梨醇、0.3g维生素E,溶解后得到溶液D,用柠檬酸钠调节pH值至中性,得到溶液D;
e.将溶液D与溶液A混合,定容至100ml,得到成品。
实施例3
绿色洗洁精的组分:十二烷基苯磺酸钠8%,脂肪醇聚氧乙烯醚硫酸钠12%,烷基糖苷5%,聚乙烯吡咯烷酮1%,NP10抗菌肽0.15%,柠檬酸钠0.1%,尿素1%,EDTA二钠0.1%,维生素E0.3%,山梨醇0.1%,去离子水补足余量至100%。
绿色洗洁精的制备方法如下:
a.室温下精密称取0.15g抗菌肽粉末溶于10ml蒸馏水中,得到溶液A;
b.将8g十二烷基苯磺酸钠和10ml水混合,形成十二烷基苯磺酸钠溶液;将12g脂肪醇聚氧乙烯醚硫酸钠、5g烷基糖苷和1g聚乙烯吡咯烷酮添加到30ml的水中,再与十二烷基苯磺酸钠溶液混合,得到的混合液在40℃的水浴中加热搅拌,搅拌至澄清透明,得到溶液B;
c.将1g尿素加入10ml蒸馏水中待溶解,得到溶液C;
d.向溶液C中加入0.1gEDTA二钠、0.1g山梨醇、0.3g维生素E,溶解后得到溶液D,用柠檬酸钠调节pH值至中性,得到溶液D;
e.将溶液D与溶液A混合,定容至100ml,得到成品。
对比例1
各成分的重量百分比为:十二烷基苯磺酸6%,脂肪醇聚氧乙烯醚硫酸钠10%,烷基糖苷6%,NP10抗菌肽0.1%,柠檬酸钠0.1%,氢氧化钠0.1%,尿素1%,EDTA二钠0.1%,维生素E0.3%,山梨醇0.1%,去离子水补足余量至100%。制备方法同实施例1。
对比例2
参见申请号为CN201210262175.0的专利,具体方案如下:各成分的重量百分比为:磺酸10%,水6%,NP10抗菌肽0.1%,乙醇10%,AES10%,650115%,无水焦磷酸钠5%,纯碱9%,硫酸镁2%,卡松2%,非离子表面活性剂1%,香精9%,液态皂6%,无水磺酸钠9%,片碱3%,香料3%。
对比例3
绿色洗洁精的组分:十二烷基苯磺酸8%,脂肪醇聚氧乙烯醚硫酸钠12%,NP10抗菌肽0.15%,柠檬酸钠0.1%,尿素1%,EDTA二钠0.1%,维生素E0.3%,山梨醇0.1%,去离子水补足余量至100%。
绿色洗洁精的制备方法如下:
a.室温下精密称取0.15g抗菌肽粉末溶于10ml蒸馏水中,得到溶液A;
b.将8g十二烷基苯磺酸和10ml水混合,用氢氧化钠中和pH值至7~7.5,形成十二烷基苯磺酸钠溶液;12g脂肪醇聚氧乙烯醚硫酸钠添加到30ml的水中,再与十二烷基苯磺酸钠溶液混合,所得混合液在40℃的水浴中加热搅拌,搅拌至澄清透明,得到溶液B;
c.将1g尿素加入10ml蒸馏水中待溶解,得到溶液C;
d.向溶液C中加入0.1gEDTA二钠、0.1g山梨醇、0.3g维生素E,溶解后得到溶液D,用柠檬酸钠调节pH值至中性,得到溶液D;
e.将溶液D与溶液A混合,定容至100ml,得到成品。
实施例4
抗菌实验
一、实验方法
a.大肠杆菌、金黄色葡萄球菌分别接种到6mlTSB培养基中,35℃孵育20h;白色念珠菌接种到6mlTSB培养基中,27℃孵育48h采用TTC法测定抑菌率。
b.用新鲜的TSB将大肠杆菌、金黄色葡萄球菌、白色念珠菌稀释至浓度为1×108CFU/ml(取过夜培养好的菌液1μl,加入25mlTSB中,用枪吹匀),加入到96孔板中,每孔50μl,取用TSB培养基稀释至目的浓度的药液50μl加入菌液中,每孔共100μl,大肠杆菌、金黄色葡萄球菌孵育20h,白色念珠菌孵育48h后用酶标仪在532nm处测吸光值,计算抑菌率。
二、实验分组
A.实验组1,为实施例1制备的含NP10抗菌肽的绿色抗菌洗洁精;
B.阳性对照组,为对比例1制备的不含NP10抗菌肽的绿色抗菌洗洁精;
C.阳性对照组,为对比例2制备的含磺酸和NP10抗菌肽的洗洁精;
D.实验组2,为实施例2制备的含NP10抗菌肽的绿色抗菌洗洁精;
E.实验组3,为实施例3制备的含NP10抗菌肽的绿色抗菌洗洁精;
F.阳性对照组,为对比例3制备的仅含有阴离子表面活性剂和NP10抗菌肽的洗洁精。
三、实验结果:
表1不同组别的洗洁精抑菌率结果
A | B | C | D | E | F | |
大肠杆菌 | 70.10% | 44.70% | 52.70% | 69.40% | 79.10% | 49.10% |
金黄色葡萄球菌 | 65.00% | 49.80% | 47.40% | 65.60% | 77.00% | 48.40% |
白色念珠菌 | 62.00% | 40.20% | 45.60% | 60.20% | 75.50% | 44.00% |
由表1可知,本发明提供的绿色抗菌洗洁精比三组阳性对照的抑菌率均高,说明本发明的方案中NP10抗菌肽为抑菌核心组分,同时阴离子表面活性剂和非离子表面活性剂协同作用,同时阴离子表面活性剂和非离子表面活性剂替换磺酸对提高洗洁精的抑菌性具有显著效果。
以上所述仅是本发明的优选实施方式,应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。
Claims (10)
1.一种含NP10抗菌肽的绿色抗菌洗洁精,其特征在于,包括以下质量百分含量的组分:阴离子表面活性剂14%~20%、非离子表面活性剂4%~12%、NP10抗菌肽0.10%~0.15%、柠檬酸钠0.08%~0.12%、尿素1%~3%、EDTA二钠0.08%~0.12%、山梨醇0.1%~0.3%、维生素E0.1%~0.3%,水补充至100%。
2.根据权利要求1所述的绿色抗菌洗洁精,其特征在于,包括以下质量百分含量的组分:阴离子表面活性剂18%、非离子表面活性剂8%、NP10抗菌肽0.12%、柠檬酸钠0.1%、尿素2%、EDTA二钠0.1%、山梨醇0.2%、维生素E0.2%,水补足余量至100%。
3.根据权利要求1或2所述的绿色抗菌洗洁精,其特征在于,所述阴离子表面活性剂包括月桂酰胺丙基甜菜碱、十二烷基苯磺酸钠、α-烯基磺酸钠、脂肪醇聚氧乙烯醚硫酸钠和月桂醇硫酸钠中的两种或多种。
4.根据权利要求3所述的绿色抗菌洗洁精,其特征在于,按绿色抗菌洗洁精的总质量为100%计,所述阴离子表面活性剂包括质量百分含量6%~8%十二烷基苯磺酸钠和质量百分含量8%~12%脂肪醇聚氧乙烯醚硫酸钠。
5.根据权利要求1或2所述的绿色抗菌洗洁精,其特征在于,所述非离子表面活性剂包括醇醚硫酸钠、烷基醇酰胺、腰果酚聚乙烯醚、月桂酰胺丙基氧化胺、椰油乙二醇酰胺、烷基糖苷和聚乙烯吡咯烷酮中的两种或多种。
6.根据权利要求5所述的绿色抗菌洗洁精,其特征在于,按绿色抗菌洗洁精的总质量为100%计,所述非离子表面活性剂包括质量百分含量3%~9%烷基糖苷和质量百分含量1%~3%聚乙烯吡咯烷酮。
7.根据权利要求6所述的绿色抗菌洗洁精,其特征在于,所述烷基糖苷包括C8~C10的烷基糖苷。
8.权利要求1~7任意一项所述的绿色抗菌洗洁精的制备方法,其特征在于,包括以下步骤:
1)将NP10抗菌肽溶解于水中,得到A溶液;
2)将阴离子表面活性剂和非离子表面活性剂在水浴条件下与水混合溶解,得到B溶液;
3)将尿素和水混合溶解,得到C溶液;
4)将所述C溶液与柠檬酸钠、EDTA二钠、山梨醇和维生素E混合溶解,调节所得混合液的pH值至中性,得到D溶液;
5)将所述D溶液与所述A溶液、B溶液和C溶液混合,得到绿色抗菌洗洁精;其中步骤1)~4)之间没有时间顺序的限制。
9.根据权利要求8所述的制备方法,其特征在于,步骤2)中所述水浴的温度为38~42℃。
10.权利要求1~7任意一项所述的绿色抗菌洗洁精或权利要求8或9所述制备方法制备得到的绿色抗菌洗洁精在洗涤杀菌中的应用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910548222.XA CN110283669A (zh) | 2019-06-24 | 2019-06-24 | 一种含np10抗菌肽的绿色抗菌洗洁精及其制备方法和应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910548222.XA CN110283669A (zh) | 2019-06-24 | 2019-06-24 | 一种含np10抗菌肽的绿色抗菌洗洁精及其制备方法和应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110283669A true CN110283669A (zh) | 2019-09-27 |
Family
ID=68004915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910548222.XA Pending CN110283669A (zh) | 2019-06-24 | 2019-06-24 | 一种含np10抗菌肽的绿色抗菌洗洁精及其制备方法和应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110283669A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115074188A (zh) * | 2022-07-26 | 2022-09-20 | 福建天宁金岛贝壳科技有限公司 | 一种洗涤剂产品组合物 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1354235A (zh) * | 2000-11-22 | 2002-06-19 | 上海白猫有限公司 | 一种液态餐具洗涤剂 |
CN103540429A (zh) * | 2012-07-11 | 2014-01-29 | 上海和黄白猫有限公司 | 一种护手护甲洗洁精 |
CN103540436A (zh) * | 2013-09-27 | 2014-01-29 | 安徽华印机电股份有限公司 | 一种除农残洗涤精 |
CN104513716A (zh) * | 2013-09-27 | 2015-04-15 | 天津普范科技开发有限公司 | 一种植物型环保厨房清洁剂 |
CN108685750A (zh) * | 2018-07-18 | 2018-10-23 | 湖南科技学院 | 一种抗菌肽洗手液及其制备方法 |
-
2019
- 2019-06-24 CN CN201910548222.XA patent/CN110283669A/zh active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1354235A (zh) * | 2000-11-22 | 2002-06-19 | 上海白猫有限公司 | 一种液态餐具洗涤剂 |
CN103540429A (zh) * | 2012-07-11 | 2014-01-29 | 上海和黄白猫有限公司 | 一种护手护甲洗洁精 |
CN103540436A (zh) * | 2013-09-27 | 2014-01-29 | 安徽华印机电股份有限公司 | 一种除农残洗涤精 |
CN104513716A (zh) * | 2013-09-27 | 2015-04-15 | 天津普范科技开发有限公司 | 一种植物型环保厨房清洁剂 |
CN108685750A (zh) * | 2018-07-18 | 2018-10-23 | 湖南科技学院 | 一种抗菌肽洗手液及其制备方法 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115074188A (zh) * | 2022-07-26 | 2022-09-20 | 福建天宁金岛贝壳科技有限公司 | 一种洗涤剂产品组合物 |
CN115074188B (zh) * | 2022-07-26 | 2024-01-12 | 福建天宁金岛贝壳科技有限公司 | 一种洗涤剂产品组合物 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6154935B2 (ja) | カチオン性活性成分および第四級糖から誘導された界面活性剤を含む抗菌性組成物 | |
ES2524792T3 (es) | Uso de quelantes de zinc que comprenden dtpa para inhibir la formación de biopelículas | |
JP5782603B2 (ja) | 抗菌発泡性石鹸 | |
JP6987862B2 (ja) | 微量作用金属を含む抗菌組成物 | |
KR20120013329A (ko) | 항바이러스제 및 세정제 | |
CN108135797A (zh) | 具有杀微生物性的基于醇的皮肤消毒剂 | |
JP5162191B2 (ja) | 皮膚外用剤 | |
JP7003186B2 (ja) | メゾ-2,3-ブタンジオールを含有する組成物 | |
CN105873442A (zh) | 酸溶性铜-铵络合物和铜-锌-铵络合物、组合物、制备、方法和用途 | |
JP2023075279A (ja) | カプリル酸を含む非石鹸液体洗浄剤組成物 | |
CN110283669A (zh) | 一种含np10抗菌肽的绿色抗菌洗洁精及其制备方法和应用 | |
JP2015505835A (ja) | 抗菌性組成物 | |
CN104023539A (zh) | 抗微生物组合物 | |
JP5322400B2 (ja) | バイオフィルム制御剤組成物 | |
WO2018007805A1 (en) | Hygiene products | |
US20230301884A1 (en) | Antiseptic compositions | |
KR20150036378A (ko) | 프로피오니박테리움 아크네에 대한 항균제로서의 아연 코세스 황산염 용도 | |
CN113332186A (zh) | 一种含有银离子的泡沫洗手液及其制备方法 | |
TW202222160A (zh) | 抗菌劑及其製造方法 | |
JP7340290B2 (ja) | 抗エンベロープウイルス中性洗浄剤、消毒剤組成物、及びエンベロープウイルスの不活性化方法 | |
CN108685733A (zh) | 一种强力除菌抑菌洗手液 | |
KR20000063461A (ko) | 살균 효과를 가지는 주방용 세정제 조성물 | |
US20230126284A1 (en) | Antiseptic compositions | |
HUE028147T2 (en) | Multipurpose solutions containing chamomile for contact lenses | |
WO2022244531A1 (ja) | 抗エンベロープウイルス中性洗浄剤、消毒剤組成物、及びエンベロープウイルスの不活性化方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190927 |
|
RJ01 | Rejection of invention patent application after publication |