CN110236621A - Neural casing for the suture of neural transpositional repair - Google Patents
Neural casing for the suture of neural transpositional repair Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B17/1128—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis of nerves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
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Abstract
The present invention provides a kind of neural casing for the suture of neural transpositional repair, including path section, major diameter section and the reducer being connected between major diameter section and path section；The inside of major diameter section has at least two townhouse ducts of linear connection, and the adjacent position in the adjacent townhouse duct of any two has gap and is connected；The internal diameter of reducer is gradually reduced from one end of one end to the linking path section in the townhouse duct of linking major diameter section, and path section is circular pipe.The present invention can be suitable for using during clinical neural transpositional repair single donor nerve repair simultaneously it is two or more by somatic nerves when socket suture, both it can reach the no-station pole canopy suture for repairing nerve under this reparation mode, nerve, which is sutured, for part forms good regeneration chamber and microenvironment, it is can simplify simultaneously using the operative process using the multiple injured nerves of single donor neural restoration, and nerve regneration and repairing effect can be improved.
Description
Technical field
The invention belongs to medical technical field of biological material, are related to a kind of artificial nerve catheter closed for nerve cuff seam, tool
Body is related to a kind of artificial bio-membrane's conduit that the suture of no-station pole canopy Small gap bridging can be carried out to the nerve of different size, quantity.
Background technique
Peripheral nerve injury is clinical treatment problem, and the damage of peripheral nerve detachment is needed the neural proximal end of damage
It is reconnected with distal end by artificial mode, so that proximal end regenerating nerve aixs cylinder grows into distal nerve, and distally nerve is long
Enter end-organ, the final function of restoring injured nerve.And for there are a part of peripheral nerve injury patients in clinic, it is close
Formed between terminal nerve and distal nerve longer gap (such as neurologic defect) or Proximal missing (such as Brachial Plexus Nerve Root is torn
De- wound), it is at this moment extremely difficult to the direct suture at the far and near end of injured nerve, thus be difficult to restore the function of these patient's injured nerves
Energy.If injured nerve function is extremely important, clinician can often consider to carry out remedying reparation to injured nerve, i.e., with a part
Insignificant nerve repairs injured nerve as donor, so that injured nerve function obtains a degree of recovery: such as brachial plexus
Often nerve transposition is taken to be treated in the clinical operation treatment of neurotrosis, i.e., with accessory nerve, seven mind of strong side (opposite side) neck
The brachial plexus nerve being damaged through, intercostal nerve etc. as donor nerve reparation.Traditional suturing method is that the nerve of relatively thick nerve is outer
Film suitably pulls outward, then sutures with minor diameter nerve directly outer membrane, in this case if diameter difference between two nerves
It away from larger, or to be repaired more than one, nerve, carries out when outer membrane suture that tension also can be larger at stitch points, will cause sometimes
Stitch points perilemma epineurium strips off, and causes the formation of stitch points neuroma to increase, the failure of even nerve suture, therefore brachial plexus nerve damages
Only a small number of skilled doctors with long years of standing and rich experience just can be carried out the transposition of nerve of wound at present.Therefore finding one kind can make difference straight
The method of no-station pole canopy suture, has certain clinical meaning and application prospect between diameter nerve.
It is stitched in recent years according to the peripheral nerve Small gap bridging that nerve-selective regeneration and nerve regneration Amplification Theory propose
Conjunction technology selects biological casing or artificial biological canula, Small gap bridging suture is carried out to injured nerve distance end, by dynamic
Object experiment confirms that Small gap bridging suture can obtain the restoration effect better than the suture of traditional neural outer membrane.In Small gap bridging
In sewing process, the injured nerve broken ends of fractured bone is not sutured directly, but is sutured respectively by the conduit being socketed with it.
There are many relevant report of the nerve trachea currently used for Peripheral nerve repair, as Chinese patent 99124557.1,
00126912.7、01115782.8、01108208.9、02113103.1、02105864.4、03115939.7、03134541.7、
200310101675.7、200380107471.2、20041009259.9、20041009205.6、200510039192.8、
20051002201.4、200510083957.8、200510120792.7、200510094683.2、200510060359.9、
200510063413.5、200610067183.5、200610066434.7、200610150792.6、200680043186.2、
200710097629.2、200810200385.0、200810200386.5、200810200387.X、200810208123.9、
200910001598.5, United States Patent (USP) US4534349A, US5844017, US5358475, US4863668, US4877029 etc..
Nerve trachea involved in the above related patents of comprehensive analysis, it is possible to find its purpose is by nerve trachea bridge
Reparation peripheral nerve defection is connect, has no that it is used for the relevant report of peripheral nerve Small gap bridging suture.Chinese patent
01134542.X and 011363314.2 is reported using chitosan or sodium alginate as artificial biological canula made of primary raw material,
Animal experiments prove that can be used for perineural Small gap bridging suture, which can only incite somebody to action this conduit
Conduit is fabricated to isodiametric cast casing.If carrying out small―gap suture to the nerve between different-diameter using equal diameter cast conduit
Socket suture, certainly exists conduit and the unmatched problem of diameter nerve, thus it is reported above involved in conduit it is uncomfortable
For the socket suture between different-diameter nerve.And it is suitble to the nerve trachea of neural Small gap bridging suture between different-diameter
Have no relevant report.
Summary of the invention
The object of the present invention is to provide a kind of neural casings for the suture of neural transpositional repair, can be realized and supply one
Somatic nerves repairs two or more simultaneously and is carried out the suture of no-station pole canopy Small gap bridging by somatic nerves.
For achieving the above object, the present invention adopts the following technical scheme that:
A kind of neural casing for the suture of neural transpositional repair, it is characterised in that: including path section, major diameter section and company
Connect the reducer between major diameter section and path section；Wherein:
The inside of major diameter section has at least two townhouse ducts of linear connection, the adjacent townhouse duct of any two
Adjacent position has gap and is connected；
The internal diameter of reducer is gradually reduced from one end of one end to the linking path section in the townhouse duct of linking major diameter section.
The neural casing for neural transpositional repair suture, in which: the major diameter section, the length of path section are
0.5-3.0mm, the length of the reducer are 0.5-3.0mm.
The neural casing for neural transpositional repair suture, in which: the inside diameter ranges of the path section are 1mm-
10mm。
The neural casing for neural transpositional repair suture, in which: the magnitude range of the internal diameter in each duct is 1-
10mm, and the internal diameter in each duct is same or different.
The neural casing for neural transpositional repair suture, in which: the major diameter section, path section and reducer
Thickness of pipe wall be 0.5-2.0mm.
The beneficial effects of the present invention are:
1. the nerve trachea may be implemented to a donor nerve while repair two or more by somatic nerves progress nothing
The suture of tension Small gap bridging, and the small―gap suture being formed between neural two broken ends of fractured bone beneficial to nerve growth microenvironment can sutured.
2. the conduit can simplify using realize to a donor nerve and meanwhile repair two or more by somatic nerves into
Row no-station pole canopy Small gap bridging suture operation operating process, and nerve regneration and repairing effect can be improved.
3. the nerve trachea can also repair several clinical repairs by somatic nerves using with a donor nerve.
Detailed description of the invention
Fig. 1, Fig. 2 are the structural schematic diagram of two embodiments of artificial neuron bridge joint conduit provided by the invention respectively.
Specific embodiment
The present invention is described in detail combined with specific embodiments below.
Embodiment 1
A. the preparation of the absorbable biological casing of both ends different inner diameters.
I. the casing of both ends different inner diameters prepares the design and fabrication of mold.
This casing production mold includes three parts, including biological tube guiding mold (guide reel), shape moulding sleeve and
Firm banking etc., middle sleeve guided mode tool are made by stainless steel material, the different-diameter cylinder that guidance mold one end is each 5m
Shape guide rod, the other end are 2 or multiple and different diameter cylindrical guide rod arranged in series spline structures.Connected component between two guide rods
For even transition structure, guide rod of the transition portion both ends respectively at two sides is uniformly connected.Outside shape moulding sleeve and guidance mold
Shape is similar, can form the uniform gap of wall thickness 0.3-2mm after fixed between guidance mold by pedestal and guidance mold.This mould
Tool is for the conduit sizing and amendment in the preparation process of the absorbable biological casing of both ends different inner diameters.
II. the production of the absorbable biological casing of both ends different inner diameters.
The chitosan that deacetylation is greater than 70%, weight average molecular weight 15 to 500,000 is dissolved by the concentration (W/W) of 1%-8%
In the dilute acetic acid aqueous solution of 1.5%-6%, high viscosity solution is obtained, vacuumizing and defoaming is to obtaining still spinning solution.It will spin
Silk stock solution is extruded from kettle, through spinning measuring pump-metered, is squeezed out from the cortex of hollow spinneret orifice, at the same time, by 3%-10%
NaOH (W/W) aqueous solution coagulator is squeezed out from the sandwich layer of hollow spinneret orifice.Spinning solution is directly entered 3%-10% after squeezing out
Na0H (W/W) aqueous coagulation bath, chitosan is able to that solidification is precipitated under effect while extraneous and sandwich layer coagulator, solidification
Conduit obtains the hollow conduit of both ends different inner diameters after diameter different novel deflector roll in both ends is drawn after sizing；After will be hollow
It is fixed on pedestal after on round tube catheter for combining mold, is fixed on pedestal after being inserted in sleeve corresponding with mold from taper end,
Be placed in 75% ethyl alcohol and place 2 hours, after casing is trimmed, obtain the satisfactory biological tube of shape, after put
Be placed in sterile saline store it is spare.Catheter diameter can be 0.7-6mm, wall thickness 0.3-2mm according to neural difference is repaired,
Conduit both ends internal diameter can carry out arbitrary ratio production according to mold.
As shown in Figure 1, being a kind of neural casing for the suture of neural transpositional repair provided by the invention, it is divided into three portions
Point, including path section 1, major diameter section 2 and the reducer 3 being connected between major diameter section 2 and path section 1；Wherein:
Path section 1 is the round tube of long 1.5mm, and internal diameter is unlimited, and inside diameter ranges can be 1mm-10mm；
Major diameter section 2 is the tube body of long 1.5mm, and outer rim shape is advisable with round or ellipse, and there are two inner rim tools
Townhouse duct 21, the adjacent position in described two townhouse ducts 21 have gap and are connected；The internal diameter in each duct 21 is not less than
The internal diameter of the path section 1；
The length of reducer 3 be 2mm, internal diameter is tapered, i.e., its internal diameter from linking major diameter section 2 townhouse duct 21 one
One end of end to linking path section 1 is gradually reduced.
The thickness of pipe wall of described nerve trachea each section is that 1mm is advisable.
Embodiment 2
New casing Small gap bridging sutures the big nervelet method of different-diameter.
Selecting corresponding nerve trachea according to nerve to be repaired first, (casing inner diameter selection principle is suture internal diameter=desire
It is socketed diameter nerve+0.2mm), neural residul end to be repaired is corrected, makes that its section is smooth, outer membrane is complete.Proximal is donor
Nerve (1 nerve, corresponding casing miner diameter end), distal nerve are by somatic nerves (2 or multiple nerves, corresponding casing major diameter
End).The nerve trachea chosen is placed in (set between neural two broken ends of fractured bone of the different-diameter to be sutured under 4 times of surgical operation microscope
Pipe carries out matched in advance with suture nerve).Proximal side (donor nerve) takes clinical microsutures with a needle, in novel complete
Penetrate tube wall from the outside to the core at the 1.5mm of pipe one end, away from neural nearside broken ends of fractured bone 0.5-1mm by one needle of epineurial neurorrhaphy after, then
Suture needle is passed through into tube wall from inside to outside, outer two sutures of tube wall is tensed, knots, the neural broken ends of fractured bone is embedded in about 1.5mm in casing,
A needle is stitched again suturing neural opposite side, and after this suture, two terminal nerves respectively sew up 1.5mm in casing, and the neural broken ends of fractured bone stays
There is the gap 2mm.Distal nerve side (by somatic nerves) takes clinical microsutures with a needle, in new casing bigger diameter end and the nerve
Be socketed match annular array duct 1.5mm place penetrate tube wall from the outside to the core, away from reparation nerve broken ends of fractured bone 0.5-1mm will be neural
After outer membrane sutures a needle, then suture needle passed through into tube wall from inside to outside, tenses outer two sutures of tube wall, knot, the neural broken ends of fractured bone, that is, embedding
Enter about 1.5mm in casing, other be successively sewn by somatic nerves by bigger diameter end using same procedure, in the process pay attention to distal end by
Somatic nerves is matched with the size in the duct of bigger diameter end.By above-mentioned suture, single nerve while reparation 2 can be successfully completed
Or more nerve surgical stapling operation, and since casing and diameter nerve match, suture is locally to perilemma epineurium without bright
Aobvious tension, it is ensured that epineurial complete.
Embodiment 3
New casing Small gap bridging is sewn to the nerve regneration in neural transpositional repair and the assessment of repairing effect.
A. the comparative study of the suture of new casing Small gap bridging and the suture of traditional neural outer membrane.
Experimental animal and animal model: SPF grades of healthy male SD rats 96 are chosen, 220-250 grams, are randomly divided into two
Group: new casing Small gap bridging suture group, epineurial neurorrhaphy group.Using yellow Jackets (30mg/kg) intraperitoneal anesthesia,
Exposure right side nervus tibialis and nervus peroneus communis under germ-free condition, cut off nervus tibialis and nervus peroneus communis, experiment under neural bifurcated at 5mm
Animal carries out calf with traditional neural outer membrane sewing method with the suture of new casing Small gap bridging respectively according to grouping is different respectively
Repair the animal model of nervus tibialis distal end+nervus peroneus communis in total nerve proximal end.Nerve suture operation is operated by skilled microsurgery
High seniority clinician operation, and the operation informations such as micromanipulation correlation time are recorded by assistant.
Experimental animal and postoperative 1 week, 2 weeks, 4 weeks, 12 weeks, two groups take 12 to be detected as follows (containing main at random respectively
Research method):
The observation of I ordinary circumstance: rat ordinary circumstance, operative incision healing state, operation side suffering limb activity condition, foot are burst
Ulcer situation etc..
II nervus tibialis function index: making the rat footmark traveling box of long 50cm by oneself, and bottom sets isometric wide blank sheet of paper.Use ink
It is allowed to walk in the case after the double metapedes to ankle of dip dyeing rat, clearly 4-5 pairs of bilateral footmark of record.Measure 3 variables: footmark
Length (print length, PL): the longest distance of footmark；Footmark width (toe spread, TS): 1-5 toe line away from
From；Intermediate toes width (intermediary toe spread, IT): the distance of 2-4 toe line is experiment with right sufficient data
(E) data, left foot data are normal (N) data, calculate 3 factors: footmark length factor (print length factor,
PLF)=(EPL-NPL)/NPL；Foot among footmark width factor (toe spread factor, TSF)=(ETS-NTS)/NTS
Toe width factor (intermediary toe spread factor, ITF)=(EIT-NIT)/NIT.The above-mentioned factor is substituted into
Following Bain-Mackinnon-Hunter (BMH) formula in the hope of nervus tibialis function index (tibial function index,
TFI)+45.6 (ITF) -8.8 of TFI=-37.2 (PLF)+104.4 (TSF)；.
The measurement of III Electrophysiology: it carries out including motor nerve conduction velocity using the method for muscle complex action potential
Measurement, stimulus signal are square wave, and intensity 0.9mA, wave wide 0.1ms, are recorded compound muscle action potential (CMAP) by 1 hertz of frequency.
Record stimulation sciatic nerve clamp point and distal end 30mm or so sciatic nerve respectively, obtains compound muscle action potential (CMAP) respectively
Incubation period, calculate the difference (dt) in incubation period twice, measure nerve cord length (dl) between remote proximal stimulus point, calculate movement mind
Through conduction of velocity: VCMAP=dl/dt, while recording in electrophysiologicalmeasurements measurements area under maximum amplitude.
The measurement of IV muscular biomechanics: the mandatory convergent force of observation muscle is measured using high frequency continuity electro photoluminescence, together
When measure opposite side normal muscle tetanic contraction power, and according to bilateral measurement data measure muscle force shrink recovery rate.
Nerve fiber, musculature and the skin histology that V materials are repaired carry out histological observation: HE dyeing, Masson dye
Color, assessment nerve suture local nerve tumor regenerate situation.
VI immunohistochemical staining (NF-200, S-100 immunohistochemical staining): it is solid that chip select is put into -20 DEG C of acetone
Fixed 20 minutes 0.3%tritong-PBS liquid is developed a film 3 times 5 minutes every time；10% normal sheep serum is closed 1 hour；Small anti-rat
NF200 monoclonal antibody with 1xPBS by 1:500 dilute, covering slice, -4 DEG C are incubated overnight；0.3%tritong-PBS liquid
It develops a film 3 times 5 minutes every time；Rabbit anti-mouse CY3 (Cyaninedyes 3) monoclonal antibody 1xPBS is diluted by 1:100, and covering is cut
Piece is incubated at room temperature 1 hour；0.3%tritong-PBS liquid is developed a film 3 times 5 minutes every time；Rabbit-anti rat S100 polyclonal antibody
1xPBS is diluted according to 1:400, and covering slice is incubated at room temperature 2 hours；0.3%tritong-PBS liquid is developed a film 3 times 5 minutes every time；
Goat-anti rabbit CY2 (Cyaninedyes 2) polyclonal antibody 1xPBS is diluted by 1:100, and covering slice is incubated at room temperature 1 hour；
0.3%tritong-PBS liquid is developed a film 3 times 5 minutes every time；Water around slide is cleaned, with fluorescence mountant mounting.
The dyeing of VII nerve fiber medullated fibers: being placed in 4% paraformaldehyde for materials nerve fiber and fix 12 hours,
Fixed and dye 12 hours after 1% osmic acid, flowing water rinses 6 hours, and distilled water immersion 1 hour totally 3 times, serial dehydration and transparent:
50% alcohol → 70% alcohol → 80% alcohol → 90% alcohol → 95% alcohol → 100% alcohol → each 15 minutes → transparent liquid
I (1 time) → each 15 minutes of transparent liquid II (2 times), waxdip: tissue block is put into waxdip 1.5 hours in waxing pool after will be transparent, organizes
Embedding, embedding are placed on balcony, histotomy: carrying out histotomy using slicer, slice thickness is that 5 μm of nerves transecteds are cut
Piece, will cut histotomy and be placed in oven roasting piece: 60 DEG C, 8~12 hours dewax transparent: by roasting piece after being taken out in oven,
It is cooled to room temperature, is placed in dewaxing liquid 5 minutes 2 times, resinene mounting is placed under microscope and is observed after stablizing, and carries out
Medullated fibers counting, aixs cylinder cross-sectional area, Myelin thickness.
VIII nerve fibre polygerm regenerates multiple: neural osmic acid stained slice will be made and observed under an optical microscope, and
Application image acquisition system acquires picture, carries out nerve fibre counting, every slice meter using Imagetool image analysis software
Number 3 times, take mean value.By the medullated fibers quantity of measurement proximal end nervus peroneus communis, distal end nervus tibialis, it is more to calculate nerve fibre
Shoot regeneration multiple.
Statistical analysis: all counting measured results carry out statistical analysis with SPSS16.0 in the studies above, compare two
Difference between group.
Experimental result is shown:
1 is obvious few compared with traditional outer membrane suture time using required time when new casing progress nerve suture.
2. it is small using the outer layer tension tradition outer membrane in stitch points part when new casing progress nerve suture, without apparent nerve
The phenomenon that outer membrane is torn.
3. all experimental animals, without apparent infection phenomenons, prompt new bio casing to have good during observation
Biocompatibility and safety.
4. the casing being socketed after suture is gradually being absorbed explanation.The visible socket group casing of 12 weeks after operation obviously drops
Solution, and formed in suture part without apparent cicatricial tissue, local nerve tumor forms unobvious.And traditional neural outer membrane suture group
Local nerve tumor is formed obviously.
5. nervous function index, Electrophysiology, muscle weight in wet base measurement result prompt: 12 weeks after surgery, being socketed suture group
It is substantially better than traditional neural outer membrane suture group.
6. mechanics feature:
Postoperative 3 days, socket repaired neural side force mean value and is higher than direct outer membrane suture group, but statistics no significant difference.
Postoperative 1 week, it is 2 weeks postoperative, socket repairs neural side force mean value higher than direct outer membrane suture group, and statistics has notable difference.
Neural side force statistics no significant difference is repaired in postoperative 4 weeks, 8 weeks, socket.
7. histological observation:
Be socketed suture group: the neural broken ends of fractured bone is not connected within postoperative 3 days two, the bleeding of visible oldness and bad at the Proximal broken ends of fractured bone
Dead tissue, inside there is inflammatory cell.Nerve fibre dyes fraction nerve disintegration at the visible broken ends of fractured bone；It is socketed visible fiber egg in gap
White sample substance, a small amount of haemocyte and inflammatory cell；The disintegration ball like cell of the visible a large amount of denaturation of distal nerve, expansion, nucleus
Increase.Postoperative 1 week, two terminal nerves were not fully connected, and Proximal preliminarily forms the growth structure of taper, still visible few in casing
Amount fibrinoid material and the inflammatory cell being dispersed in, distal nerve continue in denaturation sample, and nerve fibre is substantially completely disintegrated.
Postoperative 2 weeks, proximal end regenerating nerve grew into distal nerve, and newborn Medullary sheath degree is lower.Postoperative 4 weeks, proximal end regeneration
Distally for nerve to whole terminal growth, myelin maturity is high compared with 2 weeks for nerve fibre.Postoperative 8 weeks, histological observation was similar to 4 weeks,
Regenerating nerve myelin maturity is high compared with 4 weeks.
Outer membrane suture group: postoperative 3 days, visible a small amount of remote hemorrhage and necrotic tissue at the two neural broken ends of fractured bone, Proximal
Visible fraction nerve disintegration, is distally in denatured state at the broken ends of fractured bone.Postoperative 1 week, newborn nerve fibre passed through suture mouth and has reached
To distal end, newborn nerve fibre is thinner, and it is visible have part new life nerve fibre along suture mouth grow into outside nerve.It postoperative 2 weeks, can
See that proximal end regenerated nervous fibers continue to grow to distal nerve, sutures the nerve fibre for still having escape outside mouth, nerve fibre end
End wrapping inflammatory cell and fibroblast.Postoperative 4 weeks, 8 weeks, similar with postoperative 2 weeks, neural myelin maturity is high compared with 2 weeks.Seam
The nerve fibre of escaping of healing up still has.
Conclusion: the nerve cuff seam conjunction of different-diameter, quantity is carried out using new casing, donor regenerated nervous fibers can be suitable
Benefit is grown by small―gap suture by somatic nerves, and the suture of more traditional outer membrane can dramatically the escape for reducing nerve fibre, reduce nerve
The formation of tumor.
Described above to be merely exemplary for the purpose of the present invention, and not restrictive, those of ordinary skill in the art understand,
Without departing from the spirit and scope defined by the claims, can many modifications may be made, variation or equivalent, but will all fall
Enter within protection scope of the present invention.
Claims (5)
1. a kind of neural casing for the suture of neural transpositional repair, it is characterised in that: including path section, major diameter section and connection
Reducer between major diameter section and path section；Wherein:
The inside of major diameter section have linear connection at least two townhouse ducts, the adjacent townhouse duct of any two it is adjacent
Position has gap and is connected；
The internal diameter of reducer is gradually reduced from one end of one end to the linking path section in the townhouse duct of linking major diameter section.
2. the neural casing according to claim 1 for neural transpositional repair suture, it is characterised in that: the major diameter
Section, the length of path section are 0.5-3.0mm, and the length of the reducer is 0.5-3.0mm.
3. the neural casing according to claim 1 for neural transpositional repair suture, it is characterised in that: the path section
Inside diameter ranges be 1mm-10mm.
4. the neural casing according to claim 3 for neural transpositional repair suture, it is characterised in that: each duct it is interior
The magnitude range of diameter is 1-10mm, and the internal diameter in each duct is same or different.
5. the neural casing according to claim 1 for neural transpositional repair suture, it is characterised in that: the major diameter
The thickness of pipe wall of section, path section and reducer is 0.5-2.0mm.
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| EP0327022A2 (en) * | 1988-02-01 | 1989-08-09 | Neuroregen, L.L.C. | Bioabsorbable surgical device for treating nerve defects and method for manufacturing it |
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| CN203776949U (en) * | 2014-04-09 | 2014-08-20 | 郎利伟 | Nerve connecting pipe |
| TWM507742U (en) * | 2014-11-18 | 2015-09-01 | Shan-He Zhan | The guided nerve conduit |
| RU2572752C1 (en) * | 2014-09-30 | 2016-01-20 | Федеральное государственное бюджетное учреждение "Российский научно-исследовательский нейрохирургический институт имени профессора А.Л. Поленова" Министерства здравоохранения Российской Федерации | Method for nerve end suturing |
| CN208822856U (en) * | 2018-03-09 | 2019-05-07 | 北京大学人民医院 | Neural casing for the suture of neural transpositional repair |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0327022A2 (en) * | 1988-02-01 | 1989-08-09 | Neuroregen, L.L.C. | Bioabsorbable surgical device for treating nerve defects and method for manufacturing it |
| CN1548009A (en) * | 2003-05-22 | 2004-11-24 | 黄全顺 | Micro blood vessel anastomosing device |
| CN101138656A (en) * | 2007-09-05 | 2008-03-12 | 中国人民解放军第二军医大学 | Preparation method of chitosan composite nerve conduit |
| CN203776949U (en) * | 2014-04-09 | 2014-08-20 | 郎利伟 | Nerve connecting pipe |
| RU2572752C1 (en) * | 2014-09-30 | 2016-01-20 | Федеральное государственное бюджетное учреждение "Российский научно-исследовательский нейрохирургический институт имени профессора А.Л. Поленова" Министерства здравоохранения Российской Федерации | Method for nerve end suturing |
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