CN110192994A - A kind of white tomato whitening piece and preparation method thereof - Google Patents

A kind of white tomato whitening piece and preparation method thereof Download PDF

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Publication number
CN110192994A
CN110192994A CN201910552886.3A CN201910552886A CN110192994A CN 110192994 A CN110192994 A CN 110192994A CN 201910552886 A CN201910552886 A CN 201910552886A CN 110192994 A CN110192994 A CN 110192994A
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Prior art keywords
white tomato
whitening
white
freeze
tomato
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Inventor
薛泉
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Kunlun Technology Research (guangzhou) Co Ltd
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Kunlun Technology Research (guangzhou) Co Ltd
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Priority to CN201910552886.3A priority Critical patent/CN110192994A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208Tissues; Wipes; Patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30Characterized by the absence of a particular group of ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/84Products or compounds obtained by lyophilisation, freeze-drying

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of white tomato whitening pieces and preparation method thereof, the white tomato whitening piece is mainly made by way of tabletting after mixed in equal amounts of white tomato freeze-dried powder 200mg-900mg, acerola concentrate extract 10mg-280mg, kudzu-vine root powder 1mg-120mg, grape seed extract 1mg-200mg and Fructus piperis nigrum extract 1mg-15mg, in order to which improvement effect can also increase L-cysteine 90mg-500mg or yeast extract 90mg-500mg and seabuckthorn fruit powder 1mg-180mg in formula;The formula has many advantages, such as that whitening effect is good, the whitening period is short, highly-safe, effectively improves the absorptivity of the nutrition such as white tomato by adding appropriate Fructus piperis nigrum extract.

Description

A kind of white tomato whitening piece and preparation method thereof
Technical field
The present invention discloses the technical field for being related to whitening product more particularly to a kind of white tomato whitening piece and its preparation side Method.
Background technique
As the improvement of people's living standards, rhythm of life is getting faster, lead to people's lives pressure and operating pressure All incrementally increase.More and more people get used to staying up late, and cause the melanin in skin more and more, show skin secretly Light, wax yellow, blackening symptom shows the bad state of mental attitude.
Currently, have much about the product of whitening on the market, but ineffective, and those effects can with product in mostly Contain hormone constituents again, is unfavorable for human health.
Therefore, a kind of novel whitening product how is researched and developed, to solve the above problems, becomes that people are urgently to be resolved to be asked Topic.
Summary of the invention
In consideration of it, the present disclosure provides a kind of white tomato whitening piece and preparation method thereof, it is existing at least to solve The problems such as whitening product is unfavorable for human health there are whitening effect difference or containing hormone.
One aspect of the present invention provides a kind of white tomato whitening piece, which includes following ingredient: white tomato freeze-dried powder 200mg-900mg, acerola concentrate extract 10mg-280mg, kudzu-vine root powder 1mg-120mg, grape seed extract 1mg-200mg with And Fructus piperis nigrum extract 1mg-15mg.
It is preferred that the purity of the Fructus piperis nigrum extract is 90% or more.
Further preferably, the white tomato freeze-dried powder specific the preparation method comprises the following steps:
Under vacuum conditions by white tomato, it is freeze-dried;
Under the conditions of temperature is -38 DEG C below, the white tomato after above-mentioned freeze-drying is subjected to low-temperature grinding, it is desirable that grain Degree is 80~120 mesh, obtains white tomato freeze-dried powder.
Further preferably, the white tomato whitening piece, further includes following ingredient: L-cysteine 90mg-500mg.
Further preferably, the L-cysteine is what plant fermentation obtained.
Further preferably, the white tomato whitening piece, further includes following ingredient: yeast extract 90mg-500mg and sand Spine fruit powder 1mg-180mg.
Further preferably, the yeast extract is Saccharomyces cerevisiae extract.
Another aspect of the present invention additionally provides a kind of preparation method of above-mentioned white tomato whitening piece, which is characterized in that including Following steps:
1) it under vacuum conditions by white tomato, is freeze-dried;
2) under the conditions of temperature is -38 DEG C below, the white tomato after above-mentioned freeze-drying is subjected to low-temperature grinding, it is desirable that Granularity is 80~120 mesh, obtains white tomato freeze-dried powder;
3) white tomato freeze-dried powder is mixed with other compositions using equal increments method according to formula rate, obtains mixture;
4) by after the mixture filter sterilization, tabletting is carried out, obtains finished product.
In white tomato whitening piece provided by the invention, using white tomato meal as core component, by being extracted with acerola concentrate Object, kudzu-vine root powder and grape seed extract collaboration are to realize the effect of its synthesis highlights whitening, due to what is added in the whitening piece Fructus piperis nigrum extract, can effectively facilitate absorption of the user for above-mentioned whitening composition, exclusive colourless in especially white tomato The absorption of carrotene is greatly improved, and then under the premise of not using hormone, lower amplitude shortens the whitening period, Whitening effect is obvious.
It should be understood that above general description and following detailed description be only it is exemplary and explanatory, not Disclosure of the invention can be limited.
Specific embodiment
The present invention is further explained below with reference to specific embodiment, but is not intended to restrict the invention Protection scope.
The problems such as being unfavorable for human health there are whitening effect difference or containing hormone for the existing whitening product of solution, this Embodiment provides a kind of white tomato whitening piece, which is mainly the addition for passing through Fructus piperis nigrum extract, to improve people Body and then blocks human body Tyrosinase to be inherently formed molecular formula the absorptivity of carrotene ingredient colourless in white tomato, So that Whole Body can be improved the whitening effect of skin.Specifically, the whitening piece mainly consists of the following compositions: white tomato Freeze-dried powder 200mg-900mg, acerola concentrate extract 1mg-280mg, seabuckthorn fruit powder 1mg-180mg, kudzu-vine root powder 1mg-120mg, Grape seed extract 1mg-200mg and Fructus piperis nigrum extract 1mg-55mg.
The usage mode of above-mentioned whitening piece is oral, the pressed candy of usual 750mg, each taking a piece of, the morning and evening each one Secondary, the whitening piece ingredient of above-mentioned offer is the basis of core, to further increase whitening effect, the medicine that can take in the morning Increase L-cysteine 10mg-500mg in piece, increases yeast extract 10mg-500mg and sand in the tablet taken at night Spine fruit powder 1mg-180mg, wherein be to swallow to take in the morning, is at night sublingual lozenge.
Wherein, white tomato freeze-dried powder, it is specific the preparation method comprises the following steps: 1) under vacuum conditions by white tomato, it is dry to carry out freezing It is dry;2) under the conditions of temperature is -38 DEG C below, the white tomato after above-mentioned freeze-drying is subjected to low-temperature grinding, it is desirable that granularity For 80~120 mesh, white tomato freeze-dried powder is obtained.
Due to rich in colourless carrotene, phytoene and phytofluene etc. in above-mentioned white tomato freeze-dried powder Ingredient, so far, colourless carrotene are that the most effective arch-criminal's Tyrosinase structure for blocking human body melanin production is formed Substance, therefore, it is as the core whitening composition in the whitening piece, this point is in state, Singapore that it, which has preferable whitening effect, It is authenticated in the human clinical trial at family skin center and Australian skin detection center.
Acerola concentrate extract is rich in vitamin C, while also containing vitamin A, B1, B2, E, P, niacin, anti-aging A variety of nutriments such as the factor (SOD), calcium, iron, zinc, potassium and protein, citrin therein can prevent vitamin C to be oxidized And destroyed, enhance absorption and the utilizing status of VC, delaying sanility.
Human skin elasticity can be improved in kudzu-vine root powder, more than the 10 kinds of amino acid needed containing human body and 10 various trace elements.
Grape seed extract contains procyanidine abundant, can anti-oxidant, antiallergy, delay skin aging.
Fructus piperis nigrum extract is rich in piperine, as the sorbefacient of mentioned component, particularly in white tomato meal Colourless carrotene absorption enhancement effect is great, and preferably the purity of Fructus piperis nigrum extract is 90% or more.
L-cysteine is common amino acid, can play sun-proof effect, and preferably plant fermentation obtains.
Yeast extract primarily serves moisturizing, assigns effect living, preferably bakers yeast extract (international upper vein note The whitening needle main component penetrated is exactly the glutathione in yeast extract).
Seabuckthorn fruit powder has the effects that good lead discharging, anti-oxidant.
It is mostly pure plant extracts in above-mentioned white tomato whitening piece, is free of any hormone and animal constituents, passes through The cooperation of Fructus piperis nigrum extract and white tomato freeze-dried powder can imitate while reaching whitening effect and shorten beauty of human body white cycle.
The preparation method of above-mentioned white tomato whitening piece, this method comprises the following steps:
1) it under vacuum conditions by white tomato, is freeze-dried;
2) under the conditions of temperature is -38 DEG C below, the white tomato after above-mentioned freeze-drying is subjected to low-temperature grinding, it is desirable that Granularity is 80~120 mesh, obtains white tomato freeze-dried powder;
3) white tomato freeze-dried powder is mixed with other compositions using equal increments method according to formula rate, obtains mixture;
4) by after the mixture filter sterilization, tabletting is carried out, obtains finished product.
Explanation more further is carried out to the present invention below with reference to specific embodiment.
Embodiment 1
White tomato freeze-dried powder 600mg, L-cysteine 40mg, needle is made by following component in a kind of white tomato whitening piece Cherry powder extracts 25mg, kudzu-vine root powder 15mg, grape seed extract 20mg and Fructus piperis nigrum extract 15mg, specific preparation side Method is prepared according to the method described above, obtains whitening piece A.
Embodiment 2
White tomato freeze-dried powder 600mg, yeast extract 30mg, needle is made by following component in a kind of white tomato whitening piece Cherry extract 15mg, seabuckthorn fruit powder 15mg, kudzu-vine root powder 10mg, grape seed extract 30mg and Fructus piperis nigrum extract 15mg, Specific preparation method is prepared according to the method described above, obtains whitening piece B.
Embodiment 3
A kind of white tomato whitening piece, by following component be made white tomato freeze-dried powder 600mg, acerola concentrate extract 55mg, Kudzu-vine root powder 15mg, grape seed extract 20mg and Fructus piperis nigrum extract 15mg, specific preparation method are made according to the method described above It is standby, obtain whitening piece C.
Comparative example 1
A kind of white tomato whitening piece, by following component be made white tomato freeze-dried powder 600mg, acerola concentrate extract 25mg, Kudzu-vine root powder 15mg, seabuckthorn fruit powder 25mg grape seed extract 20mg and Fructus piperis nigrum extract 15mg, specific preparation method are pressed It is prepared according to the above method, obtains whitening piece D.
Embodiment 4
Random 5 select 50 triers, and 4 every groups of triers take embodiment 1, embodiment 2, embodiment in continuous 84 days respectively 3 and comparative example 4 in white tomato whitening piece, the 5th group trier continuous 84 days, morning take the white tomato in embodiment 1 beauty White ball takes the white tomato whitening pill in embodiment 2 at night.Wherein, every metering is 0.75g, is taken twice daily, every time A piece of, other diet are normal, the trial effect of the above-mentioned 4 groups of triers of follow-up observation.
First group of trier, 30 skins after trier 42 days begin with glossy variation, and skin is begun with obviously after 84 days Whitening effect, 15 skins after trier 42 days, which start skin, to be had glossy, and whitening effect is unobvious after 84 days, 5 triers Only skin is glossy after 84 days, without any whitening effect.
Second group of trier, 32 skins after trier 42 days begin with glossy variation, and skin is begun with obviously after 84 days Whitening effect, 13 skins after trier 42 days, which start skin, to be had glossy, and whitening effect is unobvious after 84 days, 5 triers Only skin is glossy after 84 days, without any whitening effect.
Third group trier, 28 skins after trier 42 days begin with glossy variation, and skin is begun with obviously after 84 days Whitening effect, 12 skins after trier 42 days, which start skin, to be had glossy, and whitening effect is unobvious after 84 days, 10 triers Only skin is glossy after 84 days, without any whitening effect.
4th group of trier, 25 skins after trier 84 days start glossy, but whitening effect is unobvious, 25 triers Only skin is glossy after 84 days, without any whitening effect.
5th group of trier, 20 triers, 12 days skin begin with glossy variation, and skin starts obviously have beauty after 24 days White effect, trying out this 24 days beginning skin for 25 has glossy variation, and 84 days skin has and obviously has whitening effect, 5 triers 48 Its skin start it is glossy, but without any whitening effect.
It can be found from the experiment of above-mentioned trier: the white tomato whitening piece provided in the embodiment above not only whitening period It is short and efficient high and highly-safe.
Those skilled in the art after considering the specification and implementing the invention disclosed here, will readily occur to of the invention its Its embodiment.This application is intended to cover any variations, uses, or adaptations of the invention, these modifications, purposes or Person's adaptive change follows general principle of the invention and including the undocumented common knowledge in the art of the present invention Or conventional techniques.The description and examples are only to be considered as illustrative, and true scope and spirit of the invention are wanted by right It asks and points out.
It should be understood that the invention is not limited to content is described above, and can be without departing from the scope It carry out various modifications and changes.The scope of the present invention is limited only by the attached claims.

Claims (8)

1. a kind of white tomato whitening piece, which is characterized in that including following ingredient: white tomato freeze-dried powder 200mg-900mg, needle cherry Peach extract 10mg-280mg, kudzu-vine root powder 1mg-120mg, grape seed extract 1mg-200mg and Fructus piperis nigrum extract 1mg- 15mg。
2. white tomato whitening piece according to claim 1, which is characterized in that the purity of the Fructus piperis nigrum extract be 90% with On.
3. white tomato whitening piece according to claim 1, which is characterized in that the specific preparation method of the white tomato freeze-dried powder Are as follows:
Under vacuum conditions by white tomato, it is freeze-dried;
Under the conditions of temperature is -38 DEG C below, the white tomato after above-mentioned freeze-drying is subjected to low-temperature grinding, it is desirable that granularity is 80~120 mesh obtain white tomato freeze-dried powder.
4. white tomato whitening piece according to claim 1, which is characterized in that further include following ingredient: L-cysteine 90mg- 500mg。
5. white tomato whitening piece according to claim 4, which is characterized in that the L-cysteine is plant fermentation acquisition 's.
6. white tomato whitening piece according to claim 1, which is characterized in that further include following ingredient: yeast extract 90mg- 500mg and seabuckthorn fruit powder 1mg-180mg.
7. white tomato whitening piece according to claim 6, which is characterized in that the yeast extract is Saccharomyces cerevisiae extracting Object.
8. a kind of preparation method of any white tomato whitening piece of claim 1~7, which comprises the steps of:
1) it under vacuum conditions by white tomato, is freeze-dried;
2) under the conditions of temperature is -38 DEG C below, the white tomato after above-mentioned freeze-drying is subjected to low-temperature grinding, it is desirable that granularity For 80~120 mesh, white tomato freeze-dried powder is obtained;
3) white tomato freeze-dried powder is mixed with other compositions using equal increments method according to formula rate, obtains mixture;
4) by after the mixture filter sterilization, tabletting is carried out, obtains finished product.
CN201910552886.3A 2019-06-25 2019-06-25 A kind of white tomato whitening piece and preparation method thereof Pending CN110192994A (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110839742A (en) * 2019-11-29 2020-02-28 宣城柏维力生物工程有限公司 Preparation method of sea-buckthorn tabletted candy
CN111568783A (en) * 2020-06-23 2020-08-25 昆仑技术研究(广州)有限公司 Preparation method and application of white tomato extract liposome freeze-dried powder
CN112618426A (en) * 2020-06-29 2021-04-09 昆仑技术研究(广州)有限公司 Preparation method and application of water-in-oil type white tomato freeze-dried powder
CN113521136A (en) * 2021-08-04 2021-10-22 上海楷达生物科技有限公司 Composition for skin whitening and wrinkle removal
CN113831995A (en) * 2021-08-06 2021-12-24 劲牌有限公司 Composition with enhanced stability of content of active ingredients of compound wine and application thereof
WO2022238727A1 (en) * 2021-05-08 2022-11-17 Momand Hossay Methods for preparing white heirloom tomato-based compositions for skin lightening via enhanced glutathione, and associated compositions thereof
CN115944082A (en) * 2023-01-03 2023-04-11 时代生物科技(深圳)有限公司 Whitening anti-saccharification composition and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107397697A (en) * 2017-08-30 2017-11-28 永安康健药业(武汉)有限公司 A kind of whitening spot-eliminating composition and its application
CN109077311A (en) * 2018-09-18 2018-12-25 薛泉 A kind of whitening food formulation and preparation method thereof containing white tomato
CN109820167A (en) * 2019-03-26 2019-05-31 昆仑技术研究(广州)有限公司 A kind of processing method of white tomato meal

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107397697A (en) * 2017-08-30 2017-11-28 永安康健药业(武汉)有限公司 A kind of whitening spot-eliminating composition and its application
CN109077311A (en) * 2018-09-18 2018-12-25 薛泉 A kind of whitening food formulation and preparation method thereof containing white tomato
CN109820167A (en) * 2019-03-26 2019-05-31 昆仑技术研究(广州)有限公司 A kind of processing method of white tomato meal

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110839742A (en) * 2019-11-29 2020-02-28 宣城柏维力生物工程有限公司 Preparation method of sea-buckthorn tabletted candy
CN111568783A (en) * 2020-06-23 2020-08-25 昆仑技术研究(广州)有限公司 Preparation method and application of white tomato extract liposome freeze-dried powder
CN112618426A (en) * 2020-06-29 2021-04-09 昆仑技术研究(广州)有限公司 Preparation method and application of water-in-oil type white tomato freeze-dried powder
WO2022238727A1 (en) * 2021-05-08 2022-11-17 Momand Hossay Methods for preparing white heirloom tomato-based compositions for skin lightening via enhanced glutathione, and associated compositions thereof
CN113521136A (en) * 2021-08-04 2021-10-22 上海楷达生物科技有限公司 Composition for skin whitening and wrinkle removal
CN113831995A (en) * 2021-08-06 2021-12-24 劲牌有限公司 Composition with enhanced stability of content of active ingredients of compound wine and application thereof
CN113831995B (en) * 2021-08-06 2023-07-25 劲牌有限公司 Composition capable of enhancing content stability of active ingredients of compound wine and application thereof
CN115944082A (en) * 2023-01-03 2023-04-11 时代生物科技(深圳)有限公司 Whitening anti-saccharification composition and preparation method thereof

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Application publication date: 20190903