CN110179687A - A kind of multiple-effect maintenance peptide composition and its application in cosmetics - Google Patents
A kind of multiple-effect maintenance peptide composition and its application in cosmetics Download PDFInfo
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- CN110179687A CN110179687A CN201910522802.1A CN201910522802A CN110179687A CN 110179687 A CN110179687 A CN 110179687A CN 201910522802 A CN201910522802 A CN 201910522802A CN 110179687 A CN110179687 A CN 110179687A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The present invention provides a kind of multiple-effect maintenance peptide composition and its applications in cosmetics.The peptide composition includes oligopeptides -1, carnosine, blue copper peptide, palmityl tetrapeptide -7, Argireline and nonapeptide -1.The present invention for the first time compounds above-mentioned six kinds of polypeptides, the mechanism for playing maintenance effect using each polypeptide fractions is different from the site of effect, both it can individually play a role for different skin problems, it again can be synergistic for same skin problem, it is multi-pronged, efficient maintenance skin barrier enables skin return smooth, moist rich springy health status.The peptide composition is added in cosmetics by the present invention, and the cosmetics that can make have moisturizing, anti-oxidant, light spot, crease-resistant and sensitive stimulation of releiving full restoration effect, can enhance skin glossiness and compact degree, so that skin is got well state.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of peptide composition and its application in cosmetics, especially
It is related to a kind of multiple-effect maintenance peptide composition and its application in cosmetics.
Background technique
Skin be covered in one of the entire body surface of human body it is important and be the largest organ, with special independent
Function.Meanwhile the quality of facial skin state will affect others' first impression to oneself, therefore skin is always numerous personages
The key object of protection and beautification.Increase however as the age and along with modern social development's bring environmental pollution, work
Make life stress exacerbation, skin aging speed gradually accelerate, skin metabolism speed slows down, and various skin problems are therewith
Come.In addition, as the improvement of people's living standards, the crowd of beauty is increasing, however cosmetics quality is irregular not in the market
Together, in order to achieve the purpose that fast onset, wicked business can arbitrarily add the illegal drugs such as hormone, cause skin impaired, comprehensive
Show as coarse complexion turmeric, elasticity attenuation, atrophoderma, wrinkle show, pigmentation, sensitive skin and inflammatory etc..
Skin bring perplexs in order to solve these problems, and more and more scientific research personnel and businessman put into problem skin
In the exploitation of maintenance product, it is desirable to it helps consumer to restore water and moistens glossy, flexible health skin state, however it is big
The effective component of most products derives from plant, although can also reach the target of maintenance skin, plant extracts ingredient is multiple
Miscellaneous, activity is affected by environment big, is not easy to store, and the mechanism and specific ingredient for playing effect are not yet studied clear completely, blindly makes
With the ingredient with side effect may be brought into, skin is caused to bear.
CN107184511A discloses a kind of activity external application with anti-inflammatory, the regeneration of promotion skin repair and white-skinned face function
Essence and preparation method thereof.Contain natural plant extracts ingredient, the plant extract in the cosmetic formulations of the invention
Object is by Caulis Akebiae extract, Angelica Dahurica extract, Flos Sophorae extract, Radix Trichosanthis extract, tuber fleeceflower stem extract, Gentrin Knotweed P.E, river
Southern spikemoss extract, aloe extract and mint extract composition.Experiment confirms that the product is non-stimulated to skin safe, has
Significant anti-inflammatory promotes the effect of skin repair regeneration and whitening, and then can achieve the purpose that treat acne.But the plant
There are complex process for object extract, and ingredient is unclear, and mechanism of action site is indefinite, are not easy the shortcomings that storing.
Therefore, develop that a kind of mechanism of action site is clear, activity is strong, quick, curative effect is obvious and the shield of safe pro-skin
Skin ingredient is the huge challenge for realizing full restoration problem skin.
Summary of the invention
In view of the deficiencies of the prior art, the purpose of the present invention is to provide a kind of peptide composition and its in cosmetics
Using being provided in particular in a kind of multiple-effect maintenance peptide composition and its application in cosmetics.The present invention for the first time by oligopeptides -1,
Carnosine, blue copper peptide, palmityl tetrapeptide -7, Argireline and nonapeptide -1 this six kinds of polypeptides are compounded, and each polypeptide group is utilized
The mechanism that maintenance effect is waved in distribution is different from site, not only can individually play a role for different skin problems, but also can be directed to
Same skin problem is synergistic, multi-pronged, efficient maintenance skin barrier, enables skin return smooth, moist rich springy
Health status.
To achieve this purpose, the present invention adopts the following technical scheme:
In a first aspect, the peptide composition includes oligopeptides -1, carnosine, indigo plant the present invention provides a kind of peptide composition
Copper peptide, palmityl tetrapeptide -7, Argireline and nonapeptide -1.
The present invention by oligopeptides -1, carnosine, blue copper peptide, palmityl tetrapeptide -7, Argireline and nonapeptide -1 this more than six kinds
Peptide is combined, since the appearance of each skin problem is all that many factors are coefficient as a result, each factor is made
Approach, critical sites are not quite similar, and due to the biologic specificity of polypeptide, single polypeptide is sent out for specific skin problem
The effect of waving can only be directed to the critical sites of a certain particular approach, although the effect that can also play a role is limited, and for specific
The critical sites that the skin problem peptide composition can act on number of ways simultaneously repair skin problem, Duo Zhongtu
Diameter synergistic effect effectively improves skin moisturizing, anti-oxidant, light spot, crease-resistant and releive and solve the effect of sensitive stimulation multiple-effect maintenance,
Improve comprehensive repairing effect to problem skin；And both work can be individually played for different skin problems after a combination thereof
With, and can be synergistic for same skin problem, multi-pronged, efficient maintenance skin barrier enables skin return smooth, profit
Damp rich springy health status.
As the preferred technical solution of the present invention, the peptide composition includes each component of following mass percent: few
- 1 10-30% of peptide, carnosine 20-40%, blue copper peptide 10-30%, palmityl tetrapeptide -7 10-20%, Argireline 5-
10% and -1 5-10% of nonapeptide.
The mass percent of oligopeptides -1 is 10-30% in heretofore described peptide composition, such as can be 10%,
11%, 12%, 14%, 15%, 18%, 20%, 21%, 25%, 27%, 29% or 30% etc..
The mass percent of the carnosine is 20-40%, for example, can be 20%, 21%, 23%, 25%, 27%,
30%, 31%, 32%, 35%, 38% or 40% etc..
The mass percent of the indigo plant copper peptide is 10-30%, for example, can be 10%, 12%, 13%, 15%, 17%,
18%, 20%, 23%, 25%, 27%, 28% or 30% etc..
The mass percent of the palmityl tetrapeptide -7 is 10-20%, for example, can be 10%, 12%, 15%, 16%,
16.5%, 17%, 17.2%, 18%, 18.3%, 19% or 20% etc..
The mass percent of the Argireline is 5-10%, for example, can be 5%, 5.1%, 5.8%, 6%,
6.2%, 6.5%, 7%, 7.2%, 8%, 8.3%, 8.7%, 9%, 9.5% or 10% etc..
The mass percent of the nonapeptide -1 is 5-10%, for example, can be 5%, 5.1%, 5.8%, 6%, 6.2%,
6.5%, 7%, 7.2%, 8%, 8.3%, 8.7%, 9%, 9.5% or 10% etc..
Each polypeptide fractions of the present invention are synergistic by cooperating under above-mentioned special ratios, multi-pronged, can be very
It realizes well and accelerates the generation of Skin Cell, inhibit skin inflammation, eliminate the full restorations problem such as fine wrinkles and skin whitening
The U.S. flesh effect of skin.
Preferably, the peptide composition includes each component of following mass percent: -1 20-30% of oligopeptides, carnosine
30-40%, blue copper peptide 12-30%, palmityl tetrapeptide -7 15-20%, Argireline 6-10% and -1 6- of nonapeptide
10%.
It is further preferred that the peptide composition is grouped as by each group of following mass percent: oligopeptides -1 30%,
Carnosine 30%, blue copper peptide 20%, palmityl tetrapeptide -7 10%, Argireline 5% and nonapeptide -1 5%.
It is further preferred that the peptide composition is grouped as by each group of following mass percent: oligopeptides -1 10%,
Carnosine 40%, blue copper peptide 10%, palmityl tetrapeptide -7 20%, Argireline 10% and nonapeptide -1 10%.
It is further preferred that the peptide composition is grouped as by each group of following mass percent: oligopeptides -1 20%,
Carnosine 20%, blue copper peptide 30%, palmityl tetrapeptide -7 15%, Argireline 10% and nonapeptide -1 5%.
It is further preferred that the peptide composition is grouped as by each group of following mass percent: oligopeptides -1 20%,
Carnosine 40%, blue copper peptide 10%, palmityl tetrapeptide -7 15%, Argireline 5% and nonapeptide -1 10%.
Second aspect, the present invention provides a kind of cosmetics, the cosmetics include polypeptide group as described in relation to the first aspect
Close object.
Cosmetics of the present invention include foregoing peptide composition, and the cosmetics for adding the peptide composition have
Moisturizing, anti-oxidant, light spot, crease-resistant and sensitive stimulation of releiving full restoration effect can enhance the glossiness of skin and compact
Degree makes skin get well state.
Preferably, it is 0.05-20%, example that the additive amount of the peptide composition, which accounts for the mass percentage of the cosmetics,
Such as can be 0.05%, 0.06%, 0.08%, 0.09%, 0.1%, 0.15%, 0.2%, 0.3%, 0.5%, 0.8%, 1%,
1.1%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 3%, 3.5%, 4%, 5%, 7%, 8%, 10%, 11%, 11.1%,
11.5%, 12%, 12.5%, 13%, 13.5%, 14%, 14.2%, 14.5%, 14.7%, 15%, 15.6%, 17%,
17.2%, 18%, 18.5%, 19%, 19.6% or 20% etc., preferably 0.5-10%.
Preferably, the cosmetics include lotion, cream, toner, facial mask or facial cleanser.
Preferably, the cosmetics include water phase, oil phase and addition phase.
Preferably, the water phase includes glycerol, EDETATE SODIUM, Sodium Hyaluronate, glycine betaine, panthenol, Carbopol 941 and goes
Ionized water.
Preferably, it is described oil mutually include dimethyl silicone polymer, saualane, caprylic/capric triglyceride, shea butter,
Polysorbate -20, methyl hydroxybenzoate and Nipasol.
Wherein caprylic/capric triglyceride refers to: the high-purity grease as made of caprylic/capric and glycerine esterification has
Good spreadability makes skin have smooth but not greasy feeling, is easy to be absorbed by the skin, play very to the uniform and smooth of cosmetics
Good effect, keeps skin lubrication glossy.
Preferably, the addition mutually includes butanediol, aminomethyl propanol and the peptide composition.
Preferably, the cosmetics include each component of following mass percent:
Water phase, comprising: glycerol 1-5%, EDETATE SODIUM 0.01-0.05%, Sodium Hyaluronate 0.01-0.5%, glycine betaine
0.05-1.5%, panthenol 0.05-1%, Carbopol 941 0.02-0.5% and surplus content deionized water；
Oily phase, comprising: dimethyl silicone polymer 2-6%, shea butter 1-2%, octanoic acid or Triglyceride DDD 1-3%,
Saualane 1.5-2%, -20 2-5% of polysorbate, methyl hydroxybenzoate 0.01-0.4% and Nipasol 0.01-0.14%；
Add phase, comprising: butanediol 2-7%, aminomethyl propanol 0.1-0.2% and the peptide composition 0.05-20%.
It should be noted that the mass percent of above-mentioned each component is to account for the mass percent of cosmetics gross mass.Its
In, the surplus content is solute (ingredient in water phase in addition to deionized water), oil phase and addition in the above-mentioned water phase of removal
After phase all components quality, remaining mass percentage.
It is further preferred that the cosmetics include each component of following mass percent:
Water phase, comprising: glycerol 5%, EDETATE SODIUM 0.01%, Sodium Hyaluronate 0.1%, glycine betaine 0.5%, panthenol
0.5%, the deionized water of Carbopol 941 0.2% and surplus content；
Oily phase, comprising: dimethyl silicone polymer 6%, shea butter 2%, caprylic/capric triglyceride 3%, saualane
1.5%, polysorbate -20 2%, methyl hydroxybenzoate 0.12% and Nipasol 0.02%；
Add phase, comprising: butanediol 7%, aminomethyl propanol 0.1% and peptide composition 5%.
The third aspect, the preparation method of the present invention also provides a kind of as described in second aspect cosmetics, the method packet
Include following steps:
(1) water phase components are mixed, obtains the first mixed liquor；
(2) oil phase component is mixed, obtains the second mixed liquor；
(3) the second mixed liquor that step (2) obtains is added to the first mixed liquor that step (1) obtains, mixes, vacuumizes
Emulsification, obtains third mixed liquor；
(4) the third mixed liquor that step (3) obtains is kept the temperature, it is cooling, addition phase is added, it is mixed to obtain the 4th for mixing
Close liquid；
(5) the 4th mixed liquor that step (4) obtains is cooled down again, obtains the cosmetics.
Preparation method provided by the present invention can guarantee that all materials uniformly mix in the cosmetics, to be formed steady
Determine continuous uniform mixture, cooperates between each polypeptide fractions, it is synergistic, so that the cosmetics have moisturizing, resist
Wrinkle, light spot, anti-oxidant and sensitive stimulation of releiving full restoration effect, can enhance skin glossiness and compact degree, make flesh
Skin is got well state, and water Rinsing is sliding, and compact full, shining light is adopted.
Preferably, mixing described in step (1) and step (2) is carried out at 75-85 DEG C.
Preferably, mixing described in step (1) and step (3) is carried out in emulsion pot.
Preferably, the time of emulsification described in step (3) is 5-20min.
Preferably, step (4) further include: before the mixing, step (3) is obtained into third mixed liquor and first keeps the temperature 10-
Then 30min is cooled to 30-45 DEG C.
It is further preferred that the described method comprises the following steps:
(1) water phase components are put into emulsion pot, is stirred evenly, be heated to 80 DEG C while stirring, obtain the first mixing
Liquid；
(2) oil phase component is put into oil mutually to prepare in pot, stirs evenly, is heated to 80 DEG C while stirring, obtains second
Mixed liquor；
(3) the second mixed liquor that step (2) obtains is pumped into emulsion pot, is stirred evenly, then will taken out in emulsion pot
Vacuum, emulsifying 10min obtain third mixed liquor；
(4) the third mixed liquor for obtaining step (3) keeps the temperature 15min, is subsequently cooled to 40 DEG C, and addition phase, stirring is added
Mixing, obtains the 4th mixed liquor；
(5) the 4th mixed liquor that step (4) obtains is cooled to 35 DEG C, examines qualified discharging, obtains the cosmetics.
Compared to the prior art, the invention has the following advantages:
(1) present invention for the first time by oligopeptides -1, carnosine, blue copper peptide, palmityl tetrapeptide -7, Argireline and nonapeptide -1 this
Together, antioxidant effect is obvious for six kinds of polypeptides in combination, to superoxide anion clearance rate up to 50.1-69.3%, certainly to hydroxyl
By base clearance rate up to 50.2-65.2%, meanwhile, which is added in cosmetics, skin can be also dramatically increased
Moisturizing, water lock ability, using skin moisture content after 28 days up to 16.98-23.56%, this is to take full advantage of each polypeptide
The mechanism that component plays maintenance effect is different from the site of effect, can play synergistic effect to each other；It both can be with needle after a combination thereof
It individually plays a role to different skin problems, and can be synergistic for same skin problem, multi-pronged, efficient maintenance flesh
Skin barrier enables skin return smooth, moist rich springy health status；
(2) cosmetics provided by the present invention, due to contain the peptide composition so that its with moisturizing, it is anti-oxidant,
Light spot, crease-resistant and sensitive stimulation of releiving full restoration effect, can enhance skin glossiness and compact degree, restore skin
Health status.
Specific embodiment
The technical scheme of the invention is further explained by means of specific implementation.Those skilled in the art should be bright
, the described embodiments are merely helpful in understanding the present invention, should not be regarded as a specific limitation of the invention.
Embodiment 1
A kind of multiple-effect maintenance peptide composition (I) is present embodiments provided, concrete component and mass fraction are shown in Table 1:
1 peptide composition of table (I) formula
Embodiment 2
A kind of multiple-effect maintenance peptide composition (II) is present embodiments provided, concrete component and mass fraction are shown in Table 2:
2 peptide composition of table (II) formula
Embodiment 3
A kind of multiple-effect maintenance peptide composition (III) is present embodiments provided, concrete component and mass fraction are shown in Table 3:
3 peptide composition of table (III) formula
Embodiment 4
A kind of multiple-effect maintenance peptide composition (IV) is present embodiments provided, concrete component and mass fraction are shown in Table 4:
4 peptide composition of table (IV) formula
Embodiment 5
A kind of multiple-effect maintenance peptide composition (V) is present embodiments provided, concrete component and mass fraction are shown in Table 5:
5 peptide composition of table (V) formula
Embodiment 6
A kind of multiple-effect maintenance peptide composition (VI) is present embodiments provided, concrete component and mass fraction are shown in Table 6:
6 peptide composition of table (VI) formula
Application examples 1
The application example provides a kind of maintenance lotion and preparation method thereof for containing multiple-effect maintenance peptide composition (I).
Wherein, the specific formula of lotion is as shown in table 7:
Table 7
Maintenance lotion described in the application example the preparation method is as follows:
(1) water phase components are put into emulsion pot, is stirred evenly, be heated to 80 DEG C while stirring, obtain the first mixing
Liquid；
(2) oil phase component is put into oil mutually to prepare in pot, stirs evenly, is heated to 80 DEG C while stirring, obtains second
Mixed liquor；
(3) the second mixed liquor that step (2) obtains is pumped into emulsion pot, is stirred evenly, then will taken out in emulsion pot
Vacuum, emulsifying 10min obtain third mixed liquor；
(4) the third mixed liquor for obtaining step (3) keeps the temperature 15min, is subsequently cooled to 40 DEG C, and addition phase, stirring is added
Mixing, obtains the 4th mixed liquor；
(5) the 4th mixed liquor that step (4) obtains is cooled to 35 DEG C, examines qualified discharging, obtains the maintenance lotion.
Application examples 2
The application example provides a kind of maintenance lotion and preparation method thereof of peptide composition of maintenance containing multiple-effect (II), and answers
The difference of use-case 1, which is only that, replaces with (II) for multiple-effect maintenance peptide composition (I).
Application examples 3
The application example provides a kind of maintenance lotion and preparation method thereof of peptide composition of maintenance containing multiple-effect (III), and answers
The difference of use-case 1, which is only that, replaces with (III) for multiple-effect maintenance peptide composition (I).
Application examples 4
The application example provides a kind of maintenance lotion and preparation method thereof of peptide composition of maintenance containing multiple-effect (IV), and answers
The difference of use-case 1, which is only that, replaces with (IV) for multiple-effect maintenance peptide composition (I).
Application examples 5
The application example provides a kind of maintenance lotion and preparation method thereof of peptide composition of maintenance containing multiple-effect (V), and answers
The difference of use-case 1, which is only that, replaces with (V) for multiple-effect maintenance peptide composition (I).
Application examples 6
The application example provides a kind of maintenance lotion and preparation method thereof of peptide composition of maintenance containing multiple-effect (VI), and answers
The difference of use-case 1, which is only that, replaces with (VI) for multiple-effect maintenance peptide composition (I).
Comparative example 1
This comparative example provides a kind of single polypeptide component: oligopeptides -1, quality 100g.
Comparative example 2
This comparative example provides a kind of single polypeptide component: carnosine, quality 100g.
Comparative example 3
This comparative example provides a kind of single polypeptide component: blue copper peptide, quality 100g.
Comparative example 4
This comparative example provides a kind of single polypeptide component: palmityl tetrapeptide -7, quality 100g.
Comparative example 5
This comparative example provides a kind of single polypeptide component: Argireline, quality 100g.
Comparative example 6
This comparative example provides a kind of single polypeptide component: nonapeptide -1, quality 100g.
Comparative example 7
This comparative example provides a kind of peptide composition, and the difference with embodiment 1 is only that without oligopeptides -1, concrete component
And mass fraction is shown in Table 8:
Table 8
Comparative example 8
This comparative example provides a kind of peptide composition, and the difference with embodiment 1 is only that without carnosine, concrete component and
Mass fraction is shown in Table 9:
Table 9
Comparative example 9
This comparative example provides a kind of peptide composition, and the difference with embodiment 1 is only that without blue copper peptide, concrete component
And mass fraction is shown in Table 10:
Table 10
Comparative example 10
This comparative example provides a kind of peptide composition, and the difference with embodiment 1 is only that without palmityl tetrapeptide -7, tool
Body component and mass fraction are shown in Table 11:
Table 11
Comparative example 11
This comparative example provides a kind of peptide composition, and the difference with embodiment 1 is only that without Argireline, tool
Body component and mass fraction are shown in Table 12:
Table 12
Comparative example 12
This comparative example provides a kind of peptide composition, and the difference with embodiment 1 is only that without nonapeptide -1, concrete component
And mass fraction is shown in Table 13:
Table 13
Comparative example 13
This comparative example provides a kind of peptide composition, and the difference with embodiment 1, which is only that, replaces oligopeptides -1 in formula
Mass fraction for palmityl hexapeptide -6, each component remains unchanged.
Comparative example 14
This comparative example provides a kind of peptide composition, and the difference with embodiment 1, which is only that, replaces with carnosine in formula
The mass fraction of dipeptides -4, each component remains unchanged.
Comparative example 15
This comparative example provides a kind of peptide composition, and the difference with embodiment 1 is only that copper peptide replacement blue in formula
Mass fraction for acetyl group tetrapeptide -5, each component remains unchanged.
Comparative example 16
This comparative example provides a kind of peptide composition, and the difference with embodiment 1 is only that palmityl tetrapeptide-in formula
7 replace with palmityl tetrapeptide -10, and the mass fraction of each component remains unchanged.
Comparative example 17
This comparative example provides a kind of peptide composition, and the difference with embodiment 1 is only that acetyl group hexapeptide-in formula
8 replace with Matrixyl -4, and the mass fraction of each component remains unchanged.
Comparative example 18
This comparative example provides a kind of peptide composition, and the difference with embodiment 1, which is only that, replaces nonapeptide -1 in formula
Mass fraction for tetrapeptide -30, each component remains unchanged.
Compare application examples 1
This comparison application examples provides a kind of lotion and preparation method thereof without multiple-effect maintenance peptide composition, wherein
The specific formula of lotion is as shown in table 14:
Table 14
This comparison application examples lotion the preparation method is as follows:
(1) water phase components are put into emulsion pot, is stirred evenly, be heated to 80 DEG C while stirring, obtain the first mixing
Liquid；
(2) oil phase component is put into oil mutually to prepare in pot, stirs evenly, is heated to 80 DEG C while stirring, obtains second
Mixed liquor；
(3) the second mixed liquor that step (2) obtains is pumped into emulsion pot, is stirred evenly, then will taken out in emulsion pot
Vacuum emulsifying 10 minutes, obtains third mixed liquor；
(4) the third mixed liquor for obtaining step (3) keeps the temperature 15 minutes, is subsequently cooled to 40 DEG C, and addition phase, stirring is added
Mixing, obtains the 4th mixed liquor；
(5) the 4th mixed liquor that step (4) obtains is cooled to 35 DEG C, examines qualified discharging, obtains the lotion.
Compare application examples 2
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing single polypeptide, the area with application examples 1
It is not only that the oligopeptides -1 that multiple-effect maintenance peptide composition (I) is substituted for comparative example 1.
Compare application examples 3
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing single polypeptide, the area with application examples 1
It is not only that the carnosine that multiple-effect maintenance peptide composition (I) is substituted for comparative example 2.
Compare application examples 4
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing single polypeptide, the area with application examples 1
It is not only that the blue copper peptide that multiple-effect maintenance peptide composition (I) is substituted for comparative example 3.
Compare application examples 5
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing single polypeptide, the area with application examples 1
It is not only that the palmityl tetrapeptide -7 that multiple-effect maintenance peptide composition (I) is substituted for comparative example 4.
Compare application examples 6
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing single polypeptide, the area with application examples 1
It is not only that the Argireline that multiple-effect maintenance peptide composition (I) is substituted for comparative example 5.
Compare application examples 7
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing single polypeptide, the area with application examples 1
It is not only that the nonapeptide -1 that multiple-effect maintenance peptide composition (I) is substituted for comparative example 6.
Compare application examples 8
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing peptide composition, with application examples 1
Difference is only that the peptide composition that multiple-effect maintenance peptide composition (I) is substituted for comparative example 7.
Compare application examples 9
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing peptide composition, with application examples 1
Difference is only that the peptide composition that multiple-effect maintenance peptide composition (I) is substituted for comparative example 8.
Compare application examples 10
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing peptide composition, with application examples 1
Difference is only that the peptide composition that multiple-effect maintenance peptide composition (I) is substituted for comparative example 9.
Compare application examples 11
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing peptide composition, with application examples 1
Difference is only that the peptide composition that multiple-effect maintenance peptide composition (I) is substituted for comparative example 10.
Compare application examples 12
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing peptide composition, with application examples 1
Difference is only that the peptide composition that multiple-effect maintenance peptide composition (I) is substituted for comparative example 11.
Compare application examples 13
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing peptide composition, with application examples 1
Difference is only that the peptide composition that multiple-effect maintenance peptide composition (I) is substituted for comparative example 12.
Compare application examples 14
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing peptide composition, with application examples 1
Difference is only that the peptide composition that multiple-effect maintenance peptide composition (I) is substituted for comparative example 13.
Compare application examples 15
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing peptide composition, with application examples 1
Difference is only that the peptide composition that multiple-effect maintenance peptide composition (I) is substituted for comparative example 14.
Compare application examples 16
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing peptide composition, with application examples 1
Difference is only that the peptide composition that multiple-effect maintenance peptide composition (I) is substituted for comparative example 15.
Compare application examples 17
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing peptide composition, with application examples 1
Difference is only that the peptide composition that multiple-effect maintenance peptide composition (I) is substituted for comparative example 16.
Compare application examples 18
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing peptide composition, with application examples 1
Difference is only that the peptide composition that multiple-effect maintenance peptide composition (I) is substituted for comparative example 17,.
Compare application examples 19
This comparison application examples provides a kind of maintenance lotion and preparation method thereof containing peptide composition, with application examples 1
Difference is only that the peptide composition that multiple-effect maintenance peptide composition (I) is substituted for comparative example 18.
As follows, 1-6 of the embodiment of the present invention, application examples 1-6, comparative example 1-18 and comparison application examples 1-19 are carried out
Performance test:
1, the test of skin moisture content and skin water loss (TEWL)
Moisture measurement is using universally acknowledgedMethod --- capacitance method, moisture of skin stream
It loses TEWL and parameter is very important to the function of assessment moisture of skin protective layer, have been obtained in the world very extensive
Approve.Protective layer of skin is more intact, and the content of moisture will be higher, and the numerical value of skin water loss TEWL is lower.Skin water
Divide test that can find whether the barrier protection function of skin has been destroyed in time.
The instrument that this test uses is as follows:
The skin moisture content Corneometer test of German Courage+Khazaka company (German CK company) manufacture
Probe；Skin water loss (YEWL) Tewameter of German Courage+Khazaka company (German CK company) manufacture
TM300 test probe.
The specific test method is as follows:
It chooses dry skin crowd (tingling sensation adds up >=3 points of persons) 380, the age, men and women was fifty-fifty at 20-45 years old.At random
It is divided into 19 groups, respectively number 1-19, every group of 10 males, 10 women.Any product cannot be used (to change within 15 days before recipient site
Cosmetic, topical drug, health care product for oral administration).Before test, it is desirable that subject cleans face and enters weather control within 2 hours after cleaning
Sit quietly room (22 ± 1 DEG C, relative humidity 50%) processed 20min or more, and keeps relaxation state.
Half of face test is carried out by table 15, corresponding application examples and comparison are answered in left face and right smearing table 15 on the face respectively
Use-case lotion, the left and right nasolabial groove part for choosing volunteer carry out skin moisture content and water loss (TEWL) test, take 3
The arithmetic mean of instantaneous value of value is as left and right nasolabial groove moisture content data (d0) and the data of nasolabial groove skin water loss (TEWL)
(d0).After test, volunteer need to use as required, and a side face smears application examples product, and another side face smears comparison application
Example product.Continuous use 28 days, and experimenter is required to pay a return visit at the 14th day (d14) of test and the 28th day (d28).
Table 15
2, anti-oxidation efficacy is evaluated
The polypeptide of embodiment 1-6 and comparative example 1-18 are made into the prepare liquid that concentration is 1% respectively, carry out following experiment.
(1) ultra-oxygen anion free radical Scavenging activity is evaluated
The Tris-HCl buffer solution 4.5mL for taking 0.05mol/L pH=8.2, preheats 30min in 25 DEG C of water-baths.Again
The pyrogallol solution of 1mL sample and 0.4mL 25mol/L is added, after mixing, reacts 5min in 25 DEG C of water-baths, is added
The HCl 1.0mL of 8mol/L terminates reaction.Make reference with Tris-HCl buffer solution, absorbance value is surveyed at 299nm.Blank pair
Sample is substituted according to the solvent of 1mL sample.Clearance rate (D) is calculated according to formula (1).
Ultra-oxygen anion free radical clearance rate (%)=[1- (A2/A1)] × 100% (1)
A in formula (1)1For the absorbance value of blank control；A2For the absorbance value of sample.
(2) Scavenging activity of hydroxy radical is evaluated
2mmol/L FeSO is sequentially added in 25mL cuvette43mL, 1mmol/L H2O23mL shakes up, and is subsequently added into
6mmol/L salicylic acid 3mL, shakes up, and takes out after 37 DEG C of heating water bath 15min, surveys its absorbance；It is separately added into prepare liquid, is shaken
It is even, continue heating water bath 15min, takes out and survey its absorbance.Following formula is clearance rate of the prepare liquid to hydroxy radical (OH):
Scavenging action to hydroxyl free radical (%)=[A0-Ax-(A0-Ax0)]/A0× 100% (2)
Wherein, A in formula (2)0For the absorbance value of reaction system before non-sample-adding product；AxFor system after sample removing OH
Absorbance value；Ax0The absorbance value of system after OH is removed for blank control.
3, it releives sensitive effect of stimulation functional evaluation
Efficacy assessment test method is stimulated using facial area lactic acid:
Half of face test is carried out by random table in experiment, side is the application examples 1-6 of the peptide composition of maintenance containing multiple-effect, separately
Side is comparison application examples 1 or comparison application examples 14-19, selects subject's muffle ditch portion to test, by 10% lactic acid solution
50 μ L drops inquire subject's tingling sensation in 3min, 4min, 5min respectively, by 4 point-scores on the single layer filter paper that diameter is 0.8cm
Scored (0 point is no tingling sensation, 1 point be slight shouting pain, 2 points be moderate shouting pain, 3 points are severe shouting pain), record is voluntary
The scoring of person stimulates scoring (D0) as the side lactic acid.It is smeared for 2 times sooner or later daily as requested, it is continuous 28 days on probation, and
It is required that test is paid a return visit for the 14th day (D14) and the 28th day (D28).
4, normal individual trial evaluation test
Lotion prepared by application examples 1-6, comparison application examples 1 is subjected to normal individual trial evaluation respectively.
Healthy volunteer 180 are chosen, the age, men and women was fifty-fifty at 20-45 years old.It is randomly divided into 6 groups, every group of 15 males,
15 women.Each group carries out application examples respectively and compares the check experiment of application examples, and left side uses application examples 1-6, right side respectively
It using comparison application examples 1, is persistently used 30 days respectively using primary sooner or later daily, observation uses a month rear left face and right face
Skin state.
Sample moisturizing degree, glossiness, mildness, compact degree, anti-wrinkle effect and light spot effect are commented in use process
Valence, wherein highest is divided into 5 points, minimum to be divided into 1 point.
Obtain that test result is as follows using method 1-4:
1, moisture measurement is carried out using method 1, as a result as shown in table 16 below:
16 moisture content of table tests change rate/%
Data as shown in Table 16 as it can be seen that compared with comparison application examples 1, comparison application examples 2-7 and comparison application examples 8-13,
The lotion of application examples 1-4 by addition peptide composition, compared to addition single polypeptide ingredient, any five kinds of peptide compositions or
Polypeptide moiety is not added, the moistening effect of skin is obviously improved, shows as the water that can effectively increase keratoderma
Divide content, reduces the external water loss of skin.
It can be seen that peptide composition of the invention be applied to the moistening effect in cosmetics than addition single polypeptide at
Point, any five kinds of peptide compositions or not add the moistening effect that polypeptide moiety is applied in cosmetics much better.
Comparative example 13-18 is to replace it using the polypeptide with similar maintenance respectively on the basis of embodiment 1
A kind of middle obtained peptide composition of polypeptide, such as comparative example 13 are using the same palm for having and promoting cell growth function
Acyl hexapeptide -6 replaces the oligopeptides -1 in embodiment 1.And comparative example 14-19 is the polypeptide for adding comparative example 13-18 respectively
The maintenance lotion being prepared after composition.It can be seen that the flesh using comparison application examples 14-19 lotion from the data in table 16
Skin moisture content is significantly lower than application examples 1-4, this shows that six kinds of polypeptide fractions of the invention are irreplaceable, indispensable, and six kinds
Between polypeptide fractions exist synergy, also from illustrate on the other hand peptide composition of the present invention have common maintenance skin screen
Barrier improves skin water lock, moisture-keeping functions, restores skin health, water moistens state.
2, it is tested using the anti-oxidation efficacy of method 2, as a result as shown in table 17 below:
The evaluation of 17 anti-oxidation efficacy test result of table
As it can be seen that multiple-effect maintenance peptide composition of the invention reaches as high as superoxide anion clearance rate from table 17
69.3%, 65.2% is reached as high as to Scavenging action to hydroxyl free radical, elimination effect is significantly larger than single polypeptide and containing any more than five kinds
Peptide combinations are to the clearance rates of two kinds of free radicals, while compared with comparative example 13-18, and embodiment 1-4 is to superoxide anion and hydroxyl
The clearance rate of free radical also significantly improves, this illustrate it is indispensable between six kinds of polypeptide fractions, it is synergistic, make polypeptides in combination
Object has preferable antioxidant effect.
3, it is tested using the sensitive effect of stimulation of releiving of method 3, as a result as shown in table 18 below:
Table 18 is releived the evaluation of sensitive effect of stimulation
It can be seen from the data in table 18 compared with comparing application examples 1, application examples 1-6's contains multiple-effect maintenance polypeptide
The maintenance lotion of composition has good maintenance effect to skin, can soothe the skin susceptibility, reduces lactic acid effect of stimulation, and
And there is good moistening effect, hence it is evident that increase keratoderma moisture content, reduce the external water loss of skin.And from
Application examples 14-19 data are compared it can also be seen that replacing any one in six kinds of polypeptide fractions, the moistening effect of lotion
It is decreased obviously with the ability for sensitive stimulation of releiving.It, can there are coordinated effect between this six kinds of polypeptide fractions of explanation
It is common to repair skin barrier, promote the effect of the moisturizing water lock of skin and sensitive stimulation of releiving.
4, using the normal individual trial evaluation test of method 4, as a result as shown in table 19 below:
19 normal individual trial evaluation result of table
By 19 data of table as it can be seen that the result of half face test evaluation of human body significantly contrasts this example sample and blank sample
Effect difference.It compares application examples 1-6 and compares the data of application examples 1, it can be clearly seen that the cream containing peptide composition of the present invention
Liquid is obvious to the improvement of glossiness, compact degree, anti-wrinkle effect and light spot effect, in addition, also having in terms of moisturizing good
Performance can allow the low and deep skin of relaxation to be got well state, and water Rinsing is sliding, and compact full, shining light is adopted.
The Applicant declares that the foregoing is merely a specific embodiment of the invention, but protection scope of the present invention not office
It is limited to this, it should be clear to those skilled in the art, any to belong to those skilled in the art and take off in the present invention
In the technical scope of dew, any changes or substitutions that can be easily thought of, and all of which fall within the scope of protection and disclosure of the present invention.
Claims (9)
1. a kind of peptide composition, which is characterized in that the peptide composition includes oligopeptides -1, carnosine, blue copper peptide, palmityl four
Peptide -7, Argireline and nonapeptide -1.
2. peptide composition according to claim 1, which is characterized in that the peptide composition includes following quality percentage
The each component of ratio: -1 10-30% of oligopeptides, carnosine 20-40%, blue copper peptide 10-30%, -7 10-20% of palmityl tetrapeptide, acetyl
- 1 5-10% of -8 5-10% of base hexapeptide and nonapeptide；
Preferably, the peptide composition includes each component of following mass percent: oligopeptides -1 20-30%, carnosine 30-
40%, blue copper peptide 12-30%, palmityl tetrapeptide -7 15-20%, Argireline 6-10% and -1 6-10% of nonapeptide.
3. peptide composition according to claim 1 or 2, which is characterized in that the peptide composition is by following quality hundred
The each group of ratio is divided to be grouped as: oligopeptides -1 30%, carnosine 30%, blue copper peptide 20%, palmityl tetrapeptide -7 10%, acetyl group six
Peptide -8 5% and nonapeptide -1 5%；
Preferably, the peptide composition is grouped as by each group of following mass percent: oligopeptides -1 10%, carnosine 40%, blue
Copper peptide 10%, palmityl tetrapeptide -7 20%, Argireline 10% and nonapeptide -1 10%；
Preferably, the peptide composition is grouped as by each group of following mass percent: oligopeptides -1 20%, carnosine 20%, blue
Copper peptide 30%, palmityl tetrapeptide -7 15%, Argireline 10% and nonapeptide -1 5%；
Preferably, the peptide composition is grouped as by each group of following mass percent: oligopeptides -1 20%, carnosine 40%, blue
Copper peptide 10%, palmityl tetrapeptide -7 15%, Argireline 5% and nonapeptide -1 10%.
4. a kind of cosmetics, which is characterized in that the cosmetics include the described in any item peptide compositions of claim 1-3.
5. cosmetics according to claim 4, which is characterized in that the additive amount of the peptide composition accounts for the cosmetics
Mass percentage be 0.05-20%, preferably 0.5-10%；
Preferably, the cosmetics include lotion, cream, toner, facial mask or facial cleanser.
6. cosmetics according to claim 4 or 5, which is characterized in that the cosmetics include water phase, oil mutually and add
Phase；
Preferably, the water phase includes glycerol, EDETATE SODIUM, Sodium Hyaluronate, glycine betaine, panthenol, Carbopol 941 and deionization
Water；
Preferably, the oil mutually includes dimethyl silicone polymer, saualane, caprylic/capric triglyceride, shea butter, poly- mountain
Pears alcohol ester -20, methyl hydroxybenzoate and Nipasol；
Preferably, the addition mutually includes butanediol, aminomethyl propanol and the peptide composition.
7. according to the described in any item cosmetics of claim 4-6, which is characterized in that the cosmetics include following quality percentage
The each component of ratio:
Water phase, comprising: glycerol 1-5%, EDETATE SODIUM 0.01-0.05%, Sodium Hyaluronate 0.01-0.5%, glycine betaine 0.05-
1.5%, the deionized water of panthenol 0.05-1%, Carbopol 941 0.02-0.5% and surplus content；
Oily phase, comprising: dimethyl silicone polymer 2-6%, shea butter 1-2%, caprylic/capric triglyceride 1-3%, saualane
1.5-2%, -20 2-5% of polysorbate, methyl hydroxybenzoate 0.01-0.4% and Nipasol 0.01-0.14%；
Add phase, comprising: butanediol 2-7%, aminomethyl propanol 0.1-0.2% and the peptide composition 0.05-20%.
8. according to the described in any item cosmetics of claim 4-7, which is characterized in that the cosmetics include following quality percentage
The each component of ratio:
Water phase, comprising: glycerol 5%, EDETATE SODIUM 0.01%, Sodium Hyaluronate 0.1%, glycine betaine 0.5%, panthenol 0.5%, card
The deionized water of wave nurse 941 0.2% and surplus content；
Oily phase, comprising: dimethyl silicone polymer 6%, shea butter 2%, caprylic/capric triglyceride 3%, saualane 1.5%,
Polysorbate -20 2%, methyl hydroxybenzoate 0.12% and Nipasol 0.02%；
Add phase, comprising: butanediol 7%, aminomethyl propanol 0.1% and peptide composition 5%.
9. according to the preparation method of the described in any item cosmetics of claim 4-8, which is characterized in that the method includes following
Step:
(1) water phase components are mixed, obtains the first mixed liquor；
(2) oil phase component is mixed, obtains the second mixed liquor；
(3) the second mixed liquor that step (2) obtains is added to the first mixed liquor that step (1) obtains, mixes, vacuumizes cream
Change, obtains third mixed liquor；
(4) the third mixed liquor that step (3) obtains is kept the temperature, it is cooling, addition phase is added, mixing obtains the 4th mixed liquor；
(5) the 4th mixed liquor that step (4) obtains is cooled down again, obtains the cosmetics.
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| CN115400043A (en) * | 2022-08-04 | 2022-11-29 | 广州环亚化妆品科技股份有限公司 | Anti-wrinkle composition, preparation method thereof and application thereof in cosmetics |
| CN115607499A (en) * | 2022-11-29 | 2023-01-17 | 广州名门闺秀生物科技有限责任公司 | Ginseng and ganoderma lucidum polypeptide composition for resisting wrinkles and tightening and application thereof |
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Address after: Guangzhou hi tech Industrial Development Zone, Guangzhou 5103 Patentee after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: Guangzhou hi tech Industrial Development Zone, Guangzhou 5103 Patentee before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |
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