CN110122863A - A kind of special medicine purposes food and preparation method thereof improving liver function - Google Patents
A kind of special medicine purposes food and preparation method thereof improving liver function Download PDFInfo
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- CN110122863A CN110122863A CN201910465904.4A CN201910465904A CN110122863A CN 110122863 A CN110122863 A CN 110122863A CN 201910465904 A CN201910465904 A CN 201910465904A CN 110122863 A CN110122863 A CN 110122863A
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- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 description 1
- FRASJONUBLZVQX-UHFFFAOYSA-N 1,4-naphthoquinone Chemical class C1=CC=C2C(=O)C=CC(=O)C2=C1 FRASJONUBLZVQX-UHFFFAOYSA-N 0.000 description 1
- HYPYXGZDOYTYDR-HAJWAVTHSA-N 2-methyl-3-[(2e,6e,10e,14e)-3,7,11,15,19-pentamethylicosa-2,6,10,14,18-pentaenyl]naphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 HYPYXGZDOYTYDR-HAJWAVTHSA-N 0.000 description 1
- CAXNYFPECZCGFK-UHFFFAOYSA-N 2-phenyl-2-pyridin-2-ylacetonitrile Chemical compound C=1C=CC=NC=1C(C#N)C1=CC=CC=C1 CAXNYFPECZCGFK-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 1
- 235000019750 Crude protein Nutrition 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- 235000019766 L-Lysine Nutrition 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- NPGIHFRTRXVWOY-UHFFFAOYSA-N Oil red O Chemical compound Cc1ccc(C)c(c1)N=Nc1cc(C)c(cc1C)N=Nc1c(O)ccc2ccccc12 NPGIHFRTRXVWOY-UHFFFAOYSA-N 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000786103 Steatomys pratensis Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- DJJCXFVJDGTHFX-UHFFFAOYSA-N Uridinemonophosphate Natural products OC1C(O)C(COP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-UHFFFAOYSA-N 0.000 description 1
- FOGRQMPFHUHIGU-UHFFFAOYSA-N Uridylic acid Natural products OC1C(OP(O)(O)=O)C(CO)OC1N1C(=O)NC(=O)C=C1 FOGRQMPFHUHIGU-UHFFFAOYSA-N 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 229940108925 copper gluconate Drugs 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 150000002224 folic acids Chemical class 0.000 description 1
- 230000008717 functional decline Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 229940099596 manganese sulfate Drugs 0.000 description 1
- 239000011702 manganese sulphate Substances 0.000 description 1
- 235000007079 manganese sulphate Nutrition 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 150000002711 medium chain fatty acid esters Chemical class 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- 208000037921 secondary disease Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 150000003505 terpenes Chemical group 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- DJJCXFVJDGTHFX-XVFCMESISA-N uridine 5'-monophosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-XVFCMESISA-N 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
- 230000002477 vacuolizing effect Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 235000019143 vitamin K2 Nutrition 0.000 description 1
- 239000011728 vitamin K2 Substances 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 229940041603 vitamin k 3 Drugs 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pediatric Medicine (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The application discloses a kind of special medicine purposes food, the special medicine purposes food includes 15 weight %-30 weight % of protein, 1 weight %-1.5 weight % of vitamin, 3 weight %-8 weight % of minerals, 45 weight %-60 weight % of carbohydrate, fat 12 weight %-20 weight %, dietary fiber 5 weight %-15 weight %, 1 weight %-5 weight % of branched-chain amino acid and 1 weight % nucleotide below.The special medicine purposes food of the application has the function of improving liver function.
Description
Technical field
This application involves drug fields more particularly to a kind of adjusting blood lipid composition and preparation method thereof, and adjust blood
Preparation of oil/fat composition and preparation method thereof.
Background technique
Liver is the maximum glandula digestive of human body, is the central station of body material's energetic supersession.It is estimated that occurring in liver
Chemical reaction have 500 kinds or more.Firstly, its secretion of bile, helps digest diet；Its Amino acid synthesis protein absorption
Our human body energies are supplied, let us can lustily complete darg；It can store and burn intracorporal fat,
Control our bodily form；It is the depot organ of liposoluble vitamin；It can also aoxidize, restore, decomposing intracorporal toxin, gulp down
The intracorporal bacterium of accidentally wedging is bitten, is the maximum removing toxic substances organ of human body.But it in the Working Life of reality, is endured various
At night, diet is irregular, and under the conditions of virus infection etc., liver function receives great challenge, therefore also just has various each
The generation of the liver diseases of sample: such as alcoholic liver, fatty liver, hepatitis B, liver cancer etc. seriously affects our healths.At present
Alcoholic liver is treated, fatty liver, hepatitis B, the livers such as liver cancer hiding disease method is limited, mainly takes some drop enzyme medicines, lipid-loweringing
Medicine, and such as cardiorenal function decline of some secondary diseases may also be caused with lipid-lowering medicine long-term use by dropping enzyme medicine.Improve liver function
Can primary method still must rely mainly on prevention, if alcoholic liver must be moderate in drinking or prevent to drink, supplement contain vitamin B, C, K and
The more food of folic acid class, provides good protein etc..
Summary of the invention
It is the general introduction to the theme being described in detail herein below.This general introduction is not the protection model in order to limit claim
It encloses.
It relies mainly on prevention for liver diseases, adjustment of diet is conducive to improve liver function, and this application provides one kind
Containing farnoquinone, there is the special doctor's food and preparation method for improving liver function.The spy cures food and provides for liver patient
Good protein, various vitamins, minerals, amino acid, dietary fiber, fat, carbohydrate not only can satisfy liver
The daily nutritional need of patient, can also repair the liver cell being damaged, prevent liver function from further deteriorating.
Specifically, this application provides a kind of special medicine purposes food, wherein the special medicine purposes food includes
15 weight %-30 weight % of protein, 1 weight %-1.5 weight % of vitamin, 3 weight %-8 weight % of minerals, carbon aquation
Close 45 weight %-60 weight % of object, fat 12 weight %-20 weight %, 5 weight %-15 weight % of dietary fiber, branched-amino
1 weight %-5 weight % of acid and 1 weight %% nucleotide below.
In this application, the special medicine purposes food can be oral preparation, preferably pulvis or granule.
In this application, the special medicine purposes food can be dispersible tablet, buccal tablets or chewable tablet.
In application, the special medicine purposes food can also include the acceptable addition of special medicine purposes food
Agent；
The acceptable additive of special medicine purposes food is selected from any one of lubricant and wetting agent or two kinds.
In this application, the protein can selected from any one of lactalbumin, soybean protein and whole milk powder or
It is more kinds of.
In this application, the soybean protein can be separation soybean protein or soy protein concentrate.
Soybean protein is soybean except the dregs of beans after degreasing is directly process.Soybean protein isolate is soybean except deoiling
Soluble small molecular albumen and insoluble soybean polyoses are removed after rouge and macromolecular crude protein is process.
The lactalbumin is preferably whey protein concentrate point (whey protein concentrate, wpc) or divides
It is separated from milk albumin (whey protein isolate, wpi).Sepg whey albumen is not only easy digestion, but also has Gao Sheng
Price, efficient rate, high protein effect ratio and high usage, are a kind of good proteins, are more advantageous to compromised liver function
People digest absorbs.After whey is directly dried, whey powder can be obtained, lactalbumin therein is extremely low.The clarification of whey process,
The product obtained after the processes such as ultrafiltration, drying is exactly whey protein concentrate.Sepg whey albumen is the base in whey protein concentrate
The high-purity lactalbumin obtained on plinth by further process, purity is whey protein concentrate up to 90% or more
2-3 times, be also easier to digest and assimilate.Sepg whey albumen also contains a large amount of branched-chain amino acids simultaneously, is to be most suitable for sufferer at present
Restorative nutriment.
In this application, the vitamin can be selected from vitamin A, B family vitamin, D family vitamin, choline, dimension
Raw element E, vitamin C, D-Biotin, niacin, inositol, D-VB5 calcium, folic acid, any one of farnoquinone and vitamin K1 or
It is more kinds of.
In this application, the vitamin A can be carotenoid precursors substance；
The B family vitamin can be before vitamin B1, vitamin B2, vitamin B6, vitamin 12, vitamin B1
Any one of body, vitamin B2 precursor, vitamin B6 precursor and vitamin 12 precursor or more；
The D family vitamin can be selected from any in calciferol, vitamine D3, calciferol precursor and vitamine D3
Kind or more, preferred vitamin D3.
In this application, the farnoquinone can be selected from any of chemical synthesis or natural fermented MK1 into MK14
Kind or more, preferably natural fermented MK-7.Farnoquinone, also referred to as methylnaphthoquinone (Menaquinone), usually with MK come
It indicates.It is made of one group of compound, shares 14 kinds of forms, the difference is that side chain is different in size.MK is a series of containing 2-
Methyl-1, the general designation of the terpenes side chain compound of the isoprene structures unit of 4- naphthoquinones parent nucleus and C3 with number not etc.,
According to the number of carbon on terpenes side chain, K2 (10), K2 (20), K2 (35), K2 (40) etc. can be divided into, K2 (35) is exactly to represent
MK-7。
In some embodiments of the application, the special medicine purposes food may include 15 weight %- of protein
30 weight %, 1 weight %-1.5 weight % of vitamin, minerals 3 weight %-8 weight %, 45 weight %-60 of carbohydrate
Weight %, 12 weight %-20 weight % of fat, dietary fiber 5 weight %-15 weight %, 1 weight %-5 of branched-chain amino acid weight
Measure % and 1 weight %% nucleotide below.The special medicine purposes food can also include special medicine purposes food
Acceptable additive；The acceptable additive of special medicine purposes food can appoint in lubricant and wetting agent
It is one or two kinds of.The protein can be selected from any one of lactalbumin, whole milk powder and soybean protein or more.Institute
Stating vitamin can be selected from vitamin A, B family vitamin, D family vitamin, choline, vitamin E, vitamin C, D- biology
Any one of element, niacin, inositol, D-VB5 calcium, folic acid, farnoquinone and vitamin K1 or more；The vitamin A can
Think carotenoid precursors substance；The B family vitamin can be selected from vitamin B1, vitamin B2, vitamin B6, vitamin
12, any one of precursor of vitamin b 1, vitamin B2 precursor, vitamin B6 precursor and vitamin 12 precursor or more；Institute
Stating D family vitamin can selected from any one of calciferol, vitamine D3, calciferol precursor and precursor of vitamine D 3 or more
It is a variety of, preferably vitamine D3；The farnoquinone can selected from synthesis or any one of natural fermented MK1 to MK14 or
More kinds of, preferably natural fermented MK-7.
In some embodiments of the application, the special medicine purposes food may include 15 weight %- of protein
30 weight %, 1 weight %-1.5 weight % of vitamin, minerals 3 weight %-8 weight %, 45 weight %-60 of carbohydrate
Weight %, 12 weight %-20 weight % of fat, dietary fiber 5 weight %-15 weight %, 1 weight %-5 of branched-chain amino acid weight
Measure % and 1 weight %% nucleotide below.The special medicine purposes food can also include special medicine purposes food
Acceptable additive；The acceptable additive of special medicine purposes food can appoint in lubricant and wetting agent
It is one or two kinds of.The protein can be selected from any one of lactalbumin, whole milk powder and soybean protein or more.Institute
Stating vitamin can be selected from vitamin A, B family vitamin, D family vitamin, choline, vitamin E, vitamin C, D- biology
Any one of element, niacin, inositol, D-VB5 calcium, folic acid, farnoquinone and vitamin K1 or more；The vitamin A can
Think carotenoid precursors substance；The B family vitamin can be selected from vitamin B1, vitamin B2, vitamin B6, vitamin
12, any one of precursor of vitamin b 1, vitamin B2 precursor, vitamin B6 precursor and vitamin 12 precursor or more；Institute
Stating D family vitamin is preferably vitamine D3；The farnoquinone is preferably natural fermented MK-7.
In this application, the minerals can selected from the minerals containing sodium ion, the minerals containing potassium ion, cupric from
Minerals, the minerals containing magnesium ion, the minerals containing iron ion, the minerals containing zinc ion, mineral with manganese ions of son
Any one of matter, the minerals of calcium ions, the minerals containing iodide ion and minerals containing plasma selenium or more.
In this application, the amino acid can be selected from L-lysine, L-Leu, l-Isoleucine, L-arginine, a left side
Revolve any one of carnitine and taurine or more.
In this application, the nucleotide can be selected from inosine acid disodium, Sodium guanylate, born of the same parents' sweet acid disodium and uridylic acid
Any one of disodium or more.
In this application, the fat can be selected from vegetable oil, linoleic acid, linolenic acid, medium-chain fatty glyceride and length
Any one of chain fatty acid triglyceride or more.
In this application, the dietary fiber can be selected from any one of wheat bran, oat, oligofructose and polydextrose
Or more.
In this application, the carbohydrate can form sediment selected from maltodextrin, enzymatic hydrolysis rice flour, oligomeric maltose and hydrolysis
Any one of powder or more.
The application also provides the preparation method of the special medicine purposes food, and the preparation method includes:
Addition is added in proteins,vitamins,minerals, carbohydrate, fat, dietary fiber, amino acid, nucleotide
Agent mixing mixes.
In this application, the preparation method includes:
Proteins,vitamins,minerals, carbohydrate, fat, dietary fiber, branched-chain amino acid and nucleotide are existed
It 18 DEG C -22 DEG C of temperature, mixes under humidity 45%-65% and mixes, the acceptable additive of special medicine purposes food is then added,
Obtain the oral preparation.
The application also provides the special medicine purposes food for improving the purposes in liver function.
The application's not only can satisfy liver containing farnoquinone, with the special medicine purposes food for improving liver function
The daily nutritional need of popular name for people, can also repair the liver cell being damaged, prevent liver function from further deteriorating.
Other features and advantage will illustrate in the following description, also, partly become from specification
It obtains it is clear that being understood and implementing the application.The purpose of the application and other advantages can be by specifications, right
Specifically noted structure is achieved and obtained in claim and attached drawing.
Detailed description of the invention
Attached drawing is used to provide to further understand technical scheme, and constitutes part of specification, with this
The embodiment of application is used to explain the technical solution of the application together, does not constitute the limitation to technical scheme.
Fig. 1 is the blank control group being observed visually, model meal group, model meal group+this Formula Diets group.
Fig. 2 is blank control group, high fat diet group, the high fat diet group+this Formula Diets group that microscopically observation arrives.
Specific embodiment
For the purposes, technical schemes and advantages of the application are more clearly understood, below in conjunction with attached drawing to the application
Embodiment be described in detail.It should be noted that in the absence of conflict, in the embodiment and embodiment in the application
Feature can mutual any combination.
Embodiment
The preparation of special medicine purposes food:
One, various raw materials needed for being weighed by formula rate:
1) by vitamin A retinol acetate (10%) 9mg, [B family vitamin (vitamin B1 8mg, vitamin B2 8mg,
Vitamin B6 8mg, vitamin B12 (0.1%) 1.2mg], vitamine D3 (0.25%) 11mg, choline 2.4g, vitamin E
74mg, vitamin C 314mg, D-Biotin 2%6mg, niacin 19mg, inositol 2.4g, D-VB5 calcium 25mg, folic acid 0.72mg,
Farnoquinone (0.2%) 0.2g, vitamin K1 0.24mg first use the method manual mixing of equal increments, stainless after 60 mesh
Steel sieve 3 times, obtain uniformly mixed powder 1.
2) by the sodium chloride 7.2g of minerals, potassium dihydrogen phosphate 8.4g, copper gluconate 18.6mg, magnesium sulfate 3g, lemon
Sour ferrous iron 1.6g, zinc gluconate 338mg, manganese sulfate 16.6mg, calcium carbonate 7g, potassium iodide 0.3mg, Se-enriched yeast 0.25g are first
Uniformly mixed powder 2 is obtained after 60 mesh stainless steel mesh 3 times using the method manual mixing of equal increments.
3) the L-lysine 1.5g of branched-chain amino acid, L-Leu 1.9g, l-Isoleucine 1.3g are used into equal increments
Method manual mixing obtain uniformly mixed powder 3 after 60 mesh stainless steel mesh 3 times.
4) the wheat bran 15g of dietary fiber, oat 18g, oligofructose 17g, polydextrose 17g are used to the side of equal increments
Method manual mixing obtains powder 4 after 60 mesh stainless steel mesh 3 times.
5) by the vegetable oil 7g of fat, linoleic acid 8g, linolenic acid 10g, medium-chain fatty glyceride 15g, long chain fatty acids
Glyceride 14g, in vegetable oil, linoleic acid, linolenic acid first use the powder 4 of step 4) to dilute, add medium chain fatty acid
Ester, long chain fatty acids glyceride mixture are uniform, after 60 mesh stainless steel mesh 3 times, obtain uniformly mixed powder 5.
6) by the maltodextrin 36g of carbohydrate, rice flour 70g, oligomeric maltose 40g are digested, hydrolysis starch 57g is used
The method manual mixing of equal increments obtains uniformly mixed powder 6 after 60 mesh stainless steel mesh 3 times.
7) by the inosine acid disodium 20mg of nucleotide, Sodium guanylate 20mg, born of the same parents sweet acid disodium 20mg, uridine monophosphate disodium
20mg, after 60 mesh stainless steel mesh 3 times, obtains uniformly mixed powder 7 using the method manual mixing of equal increments.
8) method of the PURE WHEY 20g of protein, soyabean protein powder 48g, whole milk powder 20g equal increments is manual
Mixing obtains uniformly mixed powder 8 after 60 mesh stainless steel mesh 3 times.
Above operating environment is completed in 100,000 grades of dust proof workshops, and 18-22 DEG C of temperature, humidity is 45-65%.
Two, the above powder 1-8 is uniformly mixed in being sequentially placed into GHL-300B efficient wet mixer-granulator, is added
Required (2% based on weight of material) magnesium stearate or 10% starch slurry 10%-15% (by weight) of concentration is made oral
Preparation.
Three, mouse experiment
Modeling method: mouse fatty liver model is established in mouse high fat diet.
Test the whether successful method of modeling: mouse liver Hematoxylin-eosin dyeing observation liver vacuolation degree.
Morphologic detection: 1 mouse liver Hematoxylin-eosin dyeing；2 mouse liver oil red O stains；3 liver Electronic Speculum ultra micros
The observation of structure.
Experimental mice: c57 mouse (18-22g)
High fat mouse grain: fat 60%, carbohydrate 20.6%, protein 19.4%.
Normal control mouse grain: fat 9%, carbohydrate 40%, protein 30%.
Experimental group mouse grain: high fat diet group adds the formula (containing farnoquinone) of the embodiment of the present application.
The above mouse grain grouping is each to feed ten weeks, stomach-filling 1g/ times, three times a day.
As a result such as Fig. 1 and Fig. 2.
It will be seen from figure 1 that the mouse liver form of Normal group is normal, and color is normal after nursing in ten weeks,
Liver surrounding tissue is normal；High fat diet group liver morphology is obviously abnormal, and the form of fatty liver is obvious, and surrounding tissue is also to be covered with
Fat.High fat diet adds this formulations group (containing farnoquinone) this it appears that mouse liver is also very close to normal control
Group.
Figure it is seen that Normal group mouse liver is sliced lobuli hepatis shape under the microscope after ten weeks feed
State is normal, and the mouse liver slice lobuli hepatis vacuole of high fat diet group is obvious, is covered with fat, it will be apparent that fatty liver form.It is high in fat
Diet adds this formulations group (containing farnoquinone) this it appears that mouse liver liver section lobuli hepatis form is very close
Normal group.
Can be seen that the special doctor's food of this formula from above result plays the role of improving liver function.
Although embodiment disclosed by the application is as above, the content only for ease of understanding the application and use
Embodiment is not limited to the application.Technical staff in any the application fields, is taken off not departing from the application
Under the premise of the spirit and scope of dew, any modification and variation, but the application can be carried out in the form and details of implementation
Scope of patent protection, still should be subject to the scope of the claims as defined in the appended claims.
Claims (15)
1. a kind of special medicine purposes food, wherein the special medicine purposes food includes 15 weight %-30 of protein weight
Measure %, vitamin weight %1-1.5 weight %, minerals 3 weight %-8 weight %, 45 weight %-60 of carbohydrate weight
Measure %, fat 12 weight %-20 weight %, 5 weight %-15 weight % of dietary fiber, 1 weight %-5 weight % of branched-chain amino acid
And 1 weight % nucleotide below.
2. special medicine purposes food according to claim 1, the special medicine purposes food also includes special medicine
The acceptable additive of purposes food；
The acceptable additive of special medicine purposes food is selected from any one of lubricant and wetting agent or two kinds.
3. special medicine purposes food according to claim 1 or 2, wherein the special medicine purposes food is oral
Preparation, preferably tablet or granule.
4. special medicine purposes food according to claim 3, wherein the special medicine purposes food be dispersible tablet,
Buccal tablets or chewable tablet.
5. special medicine purposes food according to claim 1, wherein the protein is selected from lactalbumin, whole milk
Any one of powder and soybean protein or more；
The soybean protein is separation soybean protein or soy protein concentrate.
6. according to claim 1, special medicine purposes food described in any one of 2 and 5, wherein the vitamin is selected from dimension
Raw element A, B family vitamin, D family vitamin, choline, vitamin E, vitamin C, D-Biotin, niacin, inositol, D-VB5
Any one of calcium, folic acid, farnoquinone and vitamin K1 or more；
The vitamin A is carotenoid precursors substance；
The B family vitamin is selected from vitamin B1, vitamin B2, vitamin B6, vitamin 12, precursor of vitamin b 1, vitamin
Any one of B2 precursor, vitamin B6 precursor and vitamin 12 precursor or more；
The D family vitamin be selected from any one of calciferol, vitamine D3, calciferol precursor and precursor of vitamine D 3 or
It is more kinds of, preferably vitamine D3；
The farnoquinone is selected from any one of synthesis or natural fermented MK1 to MK14 or more, preferably natural hair
The MK-7 of ferment.
7. according to claim 1, special medicine purposes food described in any one of 2 and 5, wherein the minerals, which are selected from, to be contained
The minerals of sodium ion, the minerals containing potassium ion, the minerals of copper ions, the minerals containing magnesium ion, containing iron ion
Minerals, the minerals containing zinc ion, minerals with manganese ions, the minerals of calcium ions, the minerals containing iodide ion and
Any one of minerals containing plasma selenium or more.
8. according to claim 1, special medicine purposes food described in any one of 2 and 5, wherein the branched-chain amino acid choosing
From any one of L-Leu, l-Isoleucine and Valine or more.
9. according to claim 1, special medicine purposes food described in any one of 2 and 5, wherein the nucleotide is selected from flesh
Any one of thuja acid disodium, Sodium guanylate, born of the same parents' sweet acid disodium and uridine monophosphate disodium or more.
10. according to claim 1, special medicine purposes food described in any one of 2 and 5, wherein the fat is selected from plant
Any one of oil, linoleic acid, linolenic acid, medium-chain fatty glyceride and long-chain fat acid glyceride or more.
11. according to claim 1, special medicine purposes food described in any one of 2 and 5, wherein the dietary fiber is selected from
Any one of wheat bran, oat, oligofructose and polydextrose or more.
12. according to claim 1, special medicine purposes food described in any one of 2 and 5, wherein the carbohydrate choosing
From any one of maltodextrin, enzymatic hydrolysis rice flour, oligomeric maltose and hydrolysis starch or more.
13. the preparation method of special medicine purposes food described in any one of claims 1 to 12, the preparation method packet
It includes:
Proteins,vitamins,minerals, carbohydrate, fat, dietary fiber, branched-chain amino acid and nucleotide are mixed mixed
It is even.
14. preparation method according to claim 13, wherein the preparation method includes:
By proteins,vitamins,minerals, carbohydrate, fat, dietary fiber, branched-chain amino acid and nucleotide in temperature
It 18 DEG C -22 DEG C, mixes under humidity 45%-65% and mixes, the acceptable additive of special medicine purposes food is then added, obtain
The oral preparation.
15. special medicine purposes food described in any one of claims 1 to 12 is used to improve the purposes in liver function.
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