CN110115694A - A kind of Essence with whitening, effect of dispelling spots - Google Patents
A kind of Essence with whitening, effect of dispelling spots Download PDFInfo
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- CN110115694A CN110115694A CN201910433907.XA CN201910433907A CN110115694A CN 110115694 A CN110115694 A CN 110115694A CN 201910433907 A CN201910433907 A CN 201910433907A CN 110115694 A CN110115694 A CN 110115694A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention discloses a kind of Essence with whitening, effect of dispelling spots, according to parts by weight, including following components, 0.5-4 parts of phosphatidyl choline, 0.1-5 parts of additive, -1 0.001-1 parts of nonapeptide, 0.001-0.005 parts of peptidy transeferace, peptide containing sulfydryl or 0.1-1 parts of the amino acid containing sulfydryl, dihydric alcohol or 1-25 parts of polyalcohol, 90-120 parts of water；The additive is glabridin and/or 4- butyl resorcinol；The peptide containing sulfydryl is glutathione, and the amino acid containing sulfydryl is acetylcysteine.Essence of the present invention has whitening, freckle effect, particularly has effects that synergy between the peptide containing sulfydryl or the amino acid containing sulfydryl, glabridin and/or 4- butyl resorcinol, nonapeptide -1, has good whitening effect.The Essence is without side-effects, uses within continuous 1 year, allergic phenomena will not occur in skin.The Essence stability is good, is not layered, and long shelf-life was up to 3 years at normal temperature.
Description
Technical field
The invention belongs to medicine or cosmetic field, in particular to a kind of Essences with whitening, effect of dispelling spots.
Background technique
Color spot is many kinds of, and mainly the pigmentation of local skin aggravates, and forms color and is obviously deeper than the periphery colour of skin
Region.Color spot is in dark brown or yellowish-brown, is mainly in cheek and forehead position, aggravates after solarization.Color spot formation be one very
Complicated process is worked and rested mostly with gene, diet, hormone, and the factors such as disease and improper use cosmetics are related.
External drug or cosmetic treatment color spot, effect depend on the absorption of active drug ingredient.Same drug,
Preparation is different, and transparent absorbent has very big difference, also results in and there is very big difference in therapeutic effect.Percutaneous drug delivery, medicine
The utilization rate of object is very low.External application whitening product wants the whitening spot-removing effect reached, generally requires very big drug and contains
Amount.For example contain in the pharmaceutical preparation for the treatment of chloasma currently on the market: 2%-5% quinhydrones, 20% azelaic acid.Although quinhydrones
Have the function for the treatment of chloasma with azelaic acid, but due to quinhydrones in preparation and azelaic acid excessive concentration, long-time service can draw
The side effect risen has pigmentation after primary stimulate the reaction, contact dermatitis and inflammation, and there are also exogenous ochronosis and the colour of skin
The possibility deepened.
Therefore it provides a kind of Essence with whitening, effect of dispelling spots, reduces effective component concentration, effective component is improved
Utilization rate, can not only reduce side effect, or even without side-effects to skin, can achieve good therapeutic effect, extremely have
It is necessary.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of Essence with whitening, effect of dispelling spots, the Essence
Have effects that whitening, nti-freckle, and in the Essence effective component concentration it is very low, even if be used for a long time to skin without pair
Effect, will not cause inflammation or other allergic reactions.
A kind of Essence with whitening, effect of dispelling spots, according to parts by weight, including following components, phosphatidyl choline
0.5-4 parts, 0.1-5 parts of additive, -1 0.001-1 parts of nonapeptide, 0.001-0.005 parts of peptidy transeferace, peptide containing sulfydryl or contain
0.1-1 parts of the amino acid of sulfydryl, 1-25 parts of alcohol, 90-120 parts of water；The additive is glabridin and/or 4- butyl isophthalic two
Phenol.
Preferably, a kind of Essence with whitening, effect of dispelling spots, according to parts by weight, including following components, phosphatidyl
0.5-2 parts of choline, 0.1-4 parts of additive, -1 0.001-1 parts of nonapeptide, 0.001-0.002 parts of peptidy transeferace, the peptide containing sulfydryl
Or 0.1-0.8 parts of the amino acid containing sulfydryl, 1.4-20 parts of alcohol, 90-110 parts of water；The additive is glabridin and/or 4- fourth
Base resorcinol.
It is further preferred that a kind of Essence with whitening, effect of dispelling spots, according to parts by weight, including following components,
0.8-1.5 parts of phosphatidyl choline, 0.1-3 parts of additive, -1 0.03-0.3 parts of nonapeptide, 0.001-0.002 parts of peptidy transeferace,
Peptide containing sulfydryl or 0.3-0.6 parts of the amino acid containing sulfydryl, 5-15 parts of alcohol, 90-110 parts of water；The additive is glabridin
And/or 4- butyl resorcinol.
Preferably, the phosphatidyl choline is Phosphatidylcholine Hydrogenated.
Preferably, the peptide containing sulfydryl or the amino acid containing sulfydryl are glutathione or acetylcysteine.
Preferably, the alcohol is glycerol, propylene glycol, at least two in butanediol.
A kind of preparation method of the Essence, which comprises the following steps:
(1) phosphatidyl choline is added in alcohol, then heating cools down, mixture A is obtained, by glabridin and/or 4- fourth
Base resorcinol is soluble in water, obtains mixture B, then mixture B is slowly added in mixture A, stirs, cooling, is made mixed
Object C is closed, it is spare；
(2) nonapeptide -1 is dissolved in alcohol, is then added in the mixture C of step (1) preparation, add the transfer of peptide acyl
Enzyme is stirred to react, and mixture D is made；
(3) peptide containing sulfydryl or the amino acid containing sulfydryl are mixed with water, mixture D is then added, stirred, be made described
Essence.
Specifically, a kind of preparation method with whitening, the Essence of effect of dispelling spots, comprising the following steps:
(1) phosphatidyl choline is added in alcohol, is heated to 80-90 DEG C of dissolution completely, is then cooled to 30-40 DEG C, obtains
Glabridin and/or 4- butyl resorcinol are dissolved in 50-55 DEG C of water by mixture A, obtain mixture B, then by mixture B
It is slowly added in mixture A, after constant temperature stirs 1-2 hours, is cooled to 5-25 DEG C, mixture C is made, it is spare；
(2) nonapeptide -1 is dissolved in alcohol, is then added in the mixture C of step (1) preparation, add the transfer of peptide acyl
Enzyme is stirred to react 5.5-6.5 hour at 32-38 DEG C, and mixture D is made；
(3) peptide containing sulfydryl or the amino acid containing sulfydryl and water are mixed according to the ratio that mass ratio is 0.1-1:3-15
It closes, mixture D is then added, stir 8-12 minutes, obtain with whitening, nti-freckle, Essence without side-effects.
Preferably, the mass ratio of phosphatidyl choline and alcohol is 0.5-2:0.4-10 in step (1).
Preferably, alcohol described in step (1) is glycerol.
Preferably, the mass ratio of glabridin and/or 4- butyl resorcinol and water is 0.1-5:60-85 in step (1).
Preferably, the mass ratio of nonapeptide -1 described in step (2) and alcohol is 0.001-1:0.6-15.
The whitening, nti-freckle, Essence without side-effects are used to treat various color spots, color sinks, spot, whelk.
The peptide containing sulfydryl or the amino acid containing sulfydryl are not only used as metal antidote, the weight deposited in removal skin
Metal, reducing exogenous material stimulates caused pigmentation, and the peptide containing sulfydryl or the amino acid containing sulfydryl, glabridin
And/or have effects that synergy well between 4- butyl resorcinol, nonapeptide -1, play good whitening effect.
There is the whitening also having had, nti-freckle effect in the form of Essence in the whitening, nti-freckle, Essence without side-effects
Fruit.
Compared with the existing technology, beneficial effects of the present invention are as follows:
(1) Essence of the present invention has whitening, freckle effect, the particularly peptide containing sulfydryl or the amino containing sulfydryl
Have effects that synergy well between acid, glabridin and/or 4- butyl resorcinol, nonapeptide -1, has good
Whitening effect.
(2) Essence stability of the present invention is good, is not layered, and long shelf-life was up to 3 years at normal temperature.
(3) Essence of the present invention is without side-effects, uses within continuous 1 year, skin is not in allergic phenomena.
(4) preparation process is simple, is suitble to industrial production.
Specific embodiment
In order to allow those skilled in the art that technical solution of the present invention is more clearly understood, now enumerate following embodiment into
Row explanation.It should be pointed out that following embodiment to the present invention claims protection scope do not constitute a limitation effect.
Embodiment 1
A kind of Essence with whitening, effect of dispelling spots, according to parts by weight, including following components, phosphatidyl choline 0.5
Part, 0.1 part of glabridin, 0.002 part of nonapeptide -1,0.001 part of peptidy transeferace, 0.2 part of glutathione, dihydric alcohol or polynary
15 parts of alcohol, 90 parts of water.
The dihydric alcohol or polyalcohol are 5 parts of glycerol, 10 parts of propylene glycol.
A kind of preparation method with whitening, the Essence of effect of dispelling spots, comprising the following steps:
(1) phosphatidyl choline is added in glycerol, is heated to 80 DEG C of dissolutions completely, is then cooled to 30 DEG C, is mixed
Glabridin is dissolved in 52 DEG C of 75 parts of water by object A, obtains mixture B, then mixture B is slowly added in mixture A, permanent
After temperature stirring 1 hour, 10 DEG C are cooled to, mixture C is made, it is spare；
(2) nonapeptide -1 is dissolved in propylene glycol, is then added in the mixture C of step (1) preparation, added peptide acyl and turn
Enzyme is moved, 6.5 hours are stirred to react at 32 DEG C, mixture D is made；
(3) glutathione is mixed with 15 parts of water, mixture D is then added, stirred 8-12 minutes, obtaining has beauty
White, effect of dispelling spots Essence.
Embodiment 2
A kind of Essence with whitening, effect of dispelling spots, according to parts by weight, including following components, hydrogenated phospholipid acyl gallbladder
0.6 part of alkali, 0.3 part of 4- butyl resorcinol, 0.1 part of nonapeptide -1,0.002 part of peptidy transeferace, 0.4 part of acetylcysteine,
Dihydric alcohol or 18 parts of polyalcohol, 100 parts of water.
The dihydric alcohol or polyalcohol are 8 parts of glycerol, 10 parts of butanediol.
A kind of preparation method with whitening, the Essence of effect of dispelling spots, comprising the following steps:
(1) Phosphatidylcholine Hydrogenated is added in glycerol, is heated to 85 DEG C of dissolutions completely, is then cooled to 35 DEG C, obtains
4- butyl resorcinol is dissolved in 55 DEG C of 85 parts of water by mixture A, obtains mixture B, then mixture B is slowly added to mix
It closes in object A, after constant temperature stirs 2 hours, is cooled to 25 DEG C, mixture C is made, it is spare；
(2) nonapeptide -1 is dissolved in butanediol, is then added in the mixture C of step (1) preparation, added peptide acyl and turn
Enzyme is moved, 5.5 hours are stirred to react at 38 DEG C, mixture D is made；
(3) acetylcysteine is mixed with 15 parts of water, mixture D is then added, stirred 10 minutes, obtaining has
Whitening, effect of dispelling spots Essence.
Embodiment 3
A kind of Essence with whitening, effect of dispelling spots, according to parts by weight, including following components, phosphatidyl choline 1.5
Part, 0.1 part of glabridin, 0.1 part of 4- butyl resorcinol, 0.05 part of nonapeptide -1,0.001 part of peptidy transeferace, half Guang of acetyl
0.3 part of propylhomoserin, dihydric alcohol or 20 parts of polyalcohol, 95 parts of water.
The dihydric alcohol or polyalcohol are 8 parts of glycerol, 6 parts of propylene glycol, 6 parts of butanediol.
A kind of preparation method with whitening, the Essence of effect of dispelling spots, comprising the following steps:
(1) phosphatidyl choline is added in glycerol, is heated to 83 DEG C of dissolutions completely, is then cooled to 38 DEG C, is mixed
Glabridin and 4- butyl resorcinol are dissolved in 53 DEG C of 80 water by object A, obtain mixture B, then mixture B is slowly added
Enter in mixture A, after constant temperature stirs 1.5 hours, be cooled to 25 DEG C, mixture C is made, it is spare；
(2) nonapeptide -1 is dissolved in propylene glycol and butanediol alcohol, is then added in the mixture C of step (1) preparation, then
Peptidy transeferace is added, 6 hours are stirred to react at 37 DEG C, mixture D is made；
(3) acetylcysteine is mixed with 15 parts of water, mixture D is then added, stirred 10 minutes, obtaining has
Whitening, effect of dispelling spots Essence.
Comparative example 1
Compared with Example 1, glabridin is free of in comparative example 1, remaining component and preparation process are same as Example 1.
Comparative example 2
Compared with Example 1, glutathione is free of in comparative example 2, remaining component and preparation process are same as Example 1.
Comparative example 3
Compared with Example 1, substitute nonapeptide -1 with acetyl group hexapeptide -49 in comparative example 3, remaining component and preparation process with
Embodiment 1 is identical.
Comparative example 4
Compared with Example 1, the component of Essence described in comparative example 4 is same as Example 1, but the preparation of comparative example 4
Journey only directly directly mixes all components, stirs 1 hour.
Comparative example 5
Compared with Example 3, moisture content is 5 parts in Essence described in comparative example 5, remaining component is constant, and by institute
State the form that Essence is prepared into creme.
Product measure of merit
Choosing face's melanin deposition, seriously (melanin index (MI) range between 230-250, get over by melanin index
Greatly, illustrate that melanin deposition is more serious) 180 volunteers, be randomly divided into 9 groups, every group of 20 people, by embodiment 1-3, comparative example
(commercially available whitening spot-removing China liquid is or not creme and commercially available whitening spot-removing Essence prepared by the Essence of 1-4 preparation, comparative example 5
Containing phosphatidyl choline, nonapeptide -1, glabridin and 4- butyl resorcinol) it is respectively coated in volunteer face, once in the morning and once at night,
Each dosage is 0.2mL, and the ratio that every group of volunteer's melanin index is lower than 200 is counted after 2 months, every group is counted after 4 months
Volunteer's melanin index is the ratio of 150-170, and the results are shown in Table 1.(use dermal melanin and ferroheme tester
(Mexameter MX18) detects dermal melanin index (MI), and the melanin index of normal person is in 150-250).
Table 1:
As can be seen from Table 1, the Essence whitening effect of 1-3 of embodiment of the present invention preparation is substantially better than comparative example 1-
Essence, the creme of the preparation of comparative example 5 and the whitening effect of commercially available whitening spot-removing Essence of 4 preparations.In addition, continuous use
Prepared by the embodiment of the present invention 3 occurs for Essence 1 year without cutaneous anaphylaxis, and commercially available whitening spot-removing Essence 1 is used continuously
The number that skin erythema occurs in year accounts for 30%.
In addition, (commercially available whitening spot-removing China liquid is or not Essence prepared by embodiment 2 and commercially available whitening spot-removing Essence
Containing phosphatidyl choline, nonapeptide -1, glabridin and 4- butyl resorcinol) give two groups of (every group of 10 people) ages for 13-18 years old
Volunteer with whelk uses, and once in the morning and once at night, each dosage is 0.2mL, and the impression that volunteer uses is counted after 15 days,
As a result being divided into has obvious anti-acne effect, general anti-acne effect, poor anti-acne effect.The Essence prepared using embodiment 2
The ratio that volunteer has obvious anti-acne effect is 90%, and the ratio of general anti-acne effect is 10%.Use commercially available whitening spot-removing
The ratio that the volunteer of Essence has obvious anti-acne effect is 60%, and the ratio of general anti-acne effect is 30%, poor anti-acne
Effect 10%.
Essence prepared by embodiment 3 and commercially available whitening spot-removing Essence are placed at 60 DEG C 1 day, are subsequently placed in 20 DEG C
It lower 1 day, is then placed in again at 60 DEG C 1 day, so circulation 3 times, whether observation Essence lamination, acetonideexample 3 occurs
The Essence of preparation is lamination, and commercially available whitening spot-removing Essence occurs as soon as lamination after circulation 2 times.By embodiment
3 preparation Essences at normal temperature long shelf-life up to 3 years.
Claims (10)
1. a kind of Essence with whitening, effect of dispelling spots, which is characterized in that according to parts by weight, including following components, phosphatide
0.5-4 parts of phatidylcholine, 0.1-5 parts of additive, -1 0.001-1 parts of nonapeptide, 0.001-0.005 parts of peptidy transeferace, containing sulfydryl
Peptide or 0.1-1 parts of amino acid, 1-25 parts of alcohol, 90-120 parts of water containing sulfydryl；The additive is glabridin and/or 4- butyl
Resorcinol.
2. Essence according to claim 1, which is characterized in that according to parts by weight, including following components, phosphatidyl gallbladder
0.5-2 parts of alkali, 0.1-4 parts of additive, -1 0.001-1 parts of nonapeptide, 0.001-0.002 parts of peptidy transeferace, peptide containing sulfydryl or
0.1-0.8 parts of amino acid containing sulfydryl, 1.4-20 parts of alcohol, 90-110 parts of water；The additive is glabridin and/or 4- butyl
Resorcinol.
3. Essence according to claim 1, which is characterized in that according to parts by weight, including following components, phosphatidyl gallbladder
0.8-1.5 parts of alkali, 0.1-3 parts of additive, -1 0.03-0.3 parts of nonapeptide, 0.001-0.002 parts of peptidy transeferace, containing sulfydryl
Peptide or 0.3-0.6 parts of amino acid, 5-15 parts of alcohol, 90-110 parts of water containing sulfydryl；The additive is glabridin and/or 4- fourth
Base resorcinol.
4. Essence according to claim 1, which is characterized in that the peptide containing sulfydryl is glutathione, described to contain mercapto
The amino acid of base is acetylcysteine.
5. Essence according to claim 1, which is characterized in that the alcohol be glycerol, propylene glycol, in butanediol at least
Two kinds.
6. a kind of preparation method of Essence described in any one of -5 according to claim 1, which is characterized in that including following step
It is rapid:
(1) phosphatidyl choline is added in alcohol, then heating cools down, obtain mixture A, will be between glabridin and/or 4- butyl
Benzenediol is soluble in water, obtains mixture B, then mixture B is added in mixture A, stirs, cooling, mixture C is made, standby
With；
(2) nonapeptide -1 is dissolved in alcohol, is then added in the mixture C of step (1) preparation, adds peptidy transeferace, stir
Reaction is mixed, mixture D is made；
(3) peptide containing sulfydryl or the amino acid containing sulfydryl are mixed with water, mixture D is then added, stirred, the essence is made
Liquid.
7. preparation method according to claim 6, which is characterized in that phosphorus when in alcohol is added in phosphatidyl choline in step (1)
The mass ratio of phosphatidylcholine and alcohol is 0.5-2:0.4-10；Alcohol described in step (1) is glycerol.
8. preparation method according to claim 6, which is characterized in that will be between glabridin and/or 4- butyl in step (1)
The mass ratio of glabridin and/or 4- butyl resorcinol and water is 0.1-5:60-85 when benzenediol is soluble in water.
9. preparation method according to claim 6, which is characterized in that nonapeptide -1 and the mass ratio of alcohol are in step (2)
0.001-1:0.6-15；The temperature being stirred to react in step (2) is 32-38 DEG C, and the time being stirred to react is 5.5-6.5 small
When.
10. preparation method according to claim 6, which is characterized in that by the peptide containing sulfydryl or containing sulfydryl in step (3)
Amino acid and water are mixed according to the ratio that mass ratio is 0.1-1:3-15.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113975190A (en) * | 2021-08-24 | 2022-01-28 | 宁波久瑞生物工程有限公司 | Whitening composition and application thereof |
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Application publication date: 20190813 |