CN110006790A - Cartilage permeability measurement apparatus and measurement method - Google Patents
Cartilage permeability measurement apparatus and measurement method Download PDFInfo
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- CN110006790A CN110006790A CN201910279999.0A CN201910279999A CN110006790A CN 110006790 A CN110006790 A CN 110006790A CN 201910279999 A CN201910279999 A CN 201910279999A CN 110006790 A CN110006790 A CN 110006790A
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- 210000000845 cartilage Anatomy 0.000 title claims abstract description 99
- 230000035699 permeability Effects 0.000 title claims abstract description 44
- 238000005259 measurement Methods 0.000 title claims abstract description 25
- 238000000691 measurement method Methods 0.000 title claims abstract description 12
- 238000003825 pressing Methods 0.000 claims abstract description 56
- 239000002872 contrast media Substances 0.000 claims abstract description 32
- 239000000463 material Substances 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 238000002591 computed tomography Methods 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 238000002601 radiography Methods 0.000 claims description 7
- 238000011160 research Methods 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 3
- 239000004793 Polystyrene Substances 0.000 claims description 3
- 238000009826 distribution Methods 0.000 claims description 3
- 238000010603 microCT Methods 0.000 claims description 3
- 239000004417 polycarbonate Substances 0.000 claims description 3
- 229920000515 polycarbonate Polymers 0.000 claims description 3
- 229920002530 polyetherether ketone Polymers 0.000 claims description 3
- 229920006324 polyoxymethylene Polymers 0.000 claims description 3
- 229920002223 polystyrene Polymers 0.000 claims description 3
- 238000004458 analytical method Methods 0.000 claims description 2
- 125000000129 anionic group Chemical group 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 claims description 2
- 230000007935 neutral effect Effects 0.000 claims description 2
- 230000001360 synchronised effect Effects 0.000 claims description 2
- 150000004702 methyl esters Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 15
- 230000008569 process Effects 0.000 abstract description 7
- 230000008595 infiltration Effects 0.000 description 6
- 238000001764 infiltration Methods 0.000 description 6
- 201000008482 osteoarthritis Diseases 0.000 description 6
- 210000000988 bone and bone Anatomy 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 238000002247 constant time method Methods 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 210000005065 subchondral bone plate Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N13/04—Investigating osmotic effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
- G01N2013/003—Diffusion; diffusivity between liquids
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Abstract
The present invention provides a kind of cartilage permeability measurement apparatus, by that X-ray material can be made thoroughly, including apparatus main body, porous pressure head, upper pressing means and lower pressing means；The Specimen Room of the apparatus main body is connected to hold cartilage samples, upper chamber and Specimen Room by a circular opening；The porous pressure head be with the consistent cylindrical body of opening diameter, be provided on side wall it is multiple penetrate in the gap of bottom surface, which is nested in aperture and can move freely, and the upper end is deeply in upper chamber, and lower end is deeply in Specimen Room；Pressing means are located in the upper chamber of the apparatus main body on this, can move down to contact porous pressure head upper end, and by squeezing the porous pressure head synchronizing moving；The lower pressing means are located at the bottom chamber of the apparatus main body, by moving up and down come fixed preparation bottom end.A kind of cartilage permeability measurement method is also provided.The present apparatus and method can realize cartilage compressive deformation and monitor distributed process of the contrast agent inside cartilage, and then obtain cartilage permeability results.
Description
Technical field
The present invention relates to a kind of cartilage permeability measurement apparatus and measurement method more particularly to one based on CT or Micro-CT scanning
Kind cooperation CT uses and can recycle the device and method that compression cartilage carries out permeability measurement, belongs to Novel medical and scientific research
Detecting instrument technical field.
Background technique
Osteoarthritis is common one of the joint disease of Orthopedic Clinical, it is a variety of by biology, mechanics, gene etc.
Factors are mainly shown as that cartilage degeneration, matrix components are reduced, joint space is narrow and Subchondral bone sclerosis remodeling
Deng.As social population's aging aggravates, Osteoarthritis disease incidence increases year by year, has seriously affected human health.In recent years,
People have carried out extensive research around the mechanism and lesion process of Osteoarthritis.In osteoarthritis, due to cartilage
Important component and the collagen arrangement of matrix are changed, and the transmission of cartilage inner material can inevitably be affected, because
This cartilage permeability becomes an important indicator for disclosing osteoarthritis process.Some researches show that soft in early stage osteoarthritis
The pathologic variation that matrix is compared in the infiltrative change of bone is more intuitive, obvious.
Currently, the measurement infiltrative method of cartilage has very much, it mainly include contrast agent Enhanced CT method, magnetic resonance delay
Enhance imaging method, fluorescent traccer technique and osmolality mensuration etc..Above-mentioned measurement method respectively has excellent in actual measurement application
Disadvantage, and have focused largely under the mode of " first impregnate and measure afterwards ", and contingent condition is single.In the physiological structure of joint,
Cartilage carries the function of uniformly transferring load and buffering concussion, therefore the measurement of cartilage permeability need to consider mechanics factor
It is interior, the process that cartilage bears dynamic load is simulated, as far as possible to obtain more comprehensive cartilage permeability parameter.Traditional mechanics add
It carries and sets since the use of metal parts limits loading module in the intracorporal use in the cabin CT, and in contrast agent process of osmosis
In, it cannot achieve the synchronization modulation of tissue samples load and CT scan.
Summary of the invention
The object of the present invention is to provide a kind of cartilage permeability measurement apparatus and method, it can be achieved that cartilage compressive deformation and
Distributed process of the contrast agent inside cartilage is monitored, and then obtains cartilage permeability results.
To achieve the above object, the technical solution adopted by the present invention are as follows:
A kind of cartilage permeability measurement apparatus, by X-ray material being made thoroughly, including apparatus main body, porous pressure head, it is upper plus
Casting die and lower pressing means；The apparatus main body includes upper chamber, Specimen Room and lower chambers from top to bottom, and the Specimen Room is to hold
Cartilage samples, the upper chamber and Specimen Room are connected to by a circular opening；The porous pressure head be with the consistent cylindrical body of opening diameter,
Be provided on side wall it is multiple penetrate in the gap of bottom surface, which is nested in aperture and can move freely, and the upper end is deep
To upper chamber, lower end is goed deep into Specimen Room；Pressing means are located in the upper chamber of the apparatus main body on this, can move down with
Porous pressure head upper end is contacted, and by squeezing the porous pressure head synchronizing moving；The lower pressing means are located at the cavity of resorption of the apparatus main body
Interior, by moving up and down come fixed preparation bottom end.
Further, the material is polymethyl methacrylate, polycarbonate, polystyrene, polyformaldehyde, polyether-ether-ketone
In any one or more.
Further, the inner sidewall of the upper chamber and lower chambers is equipped with screw thread, the upper pressing means and lower pressing means
Side wall be equipped with compatible screw thread, by be threadedly engaged by upper pressing means and lower pressing means be movably connected on upper chamber and under
In chamber, the position of pressing means and lower pressing means is adjusted by rotating.
Further, the upper surface of described device main body is equipped with the graduation mark for being surrounded on upper chamber port, for identifying
The angle of pressing means rotation.
Further, a contrast agent injection hole is contained in the upper chamber.
A kind of cartilage permeability measurement method, using above-mentioned cartilage permeability measurement apparatus, step includes:
Cartilage samples are placed in Specimen Room, pressing means contradict porous pressure head in movement, so that porous pressure head lower end
Cartilage surface is contacted, while mobile lower pressing means come the bottom of fixed preparation；
Contrast agent is injected into upper chamber, make contrast agent full of hole multiple pressure head hole and with cartilage face contact；
Pressing means move down in adjusting, squeeze porous pressure head and move down to compress cartilage surface, adjust pressurize again
Part moves up, to restore cartilage deformation, and so on to realize the circulation compressive deformation of cartilage；
The cartilage permeability measurement is put into CT machine and is scanned, the contrast agent under cartilage different deformation state is obtained
Distributed image determines holding time for compressive deformation according to trace interval, realizes that cartilage compressive deformation is synchronous with CT scan
It carries out, gray scale-contrast agent content analysis is carried out to CT image sequence according to standard curve, obtains cartilage permeability parameter.
Further, the contrast agent is anionic contrast agent, cationic contrast agent, one in neutral contrast agent
Kind.
Further, the CT machine is medical and clinical CT or scientific research Micro-CT scanning.
Further, the upper pressing means are threadedly connected in the upper chamber of apparatus main body, by rotating upper pressing means extremely
Certain angle compresses downwards cartilage surface to make upper pressing means squeeze porous pressure head, again the upper pressing means of reverse rotation to original position,
To restore cartilage deformation.
Compared with prior art, the present invention has the advantage that
The present apparatus is combined with CT, the contrast agent diffusion process under cartilage deformed state can be observed in real time, by mechanics factor
It takes into account and more meets articular cartilage physiological status；Different degrees of dynamic and static deformation can be applied to cartilage, obtain infiltration
Parameter is more comprehensive；Pressurizing device can saturating X-ray, can directly carry out Clinical CT or microscopic CT scanning；According to image grayscale with
Contrast agent diffusion distribution situation is directly calculated by cartilage CT image in radiography agent content correlativity, and then show that cartilage seeps
Permeability parameter, radiography agent content, infiltration rate, infiltration coefficient including different depth；Present apparatus structure and measurement method are simple,
Processing cost is low, high reliablity, can detect to all kinds of soft tissue samples, biomaterial and other permeable materials, fits
With wide.
Detailed description of the invention
Fig. 1 is the cartilage permeability measurement apparatus structural schematic diagram (left figure) of embodiment and the X ray picture (right side after contrast agent
Figure).
In figure: the upper pressing means of 1-, 2- apparatus main body, the porous pressure head of 3-, 4- contrast agent, 5- Specimen Room, pressing means under 6-.
Fig. 2 is the cartilage permeability measurement flow chart of embodiment carried out using cartilage permeability measurement apparatus.
Specific embodiment
In order to keep the objectives, technical solutions, and advantages of the present invention clearer, below in conjunction with application example to the present invention into
Row is described in detail.
The present embodiment specifically provides a kind of cartilage permeability measurement apparatus, and structure is as shown in Figure 1, include apparatus main body 2, more
Hole pressure head 3, upper pressing means 1 and lower pressing means 6；The apparatus main body 2 includes upper chamber, Specimen Room 5 and lower chambers from top to bottom,
The Specimen Room 5 is to hold cartilage samples, which is connected to Specimen Room 5 by a circular opening, the upper end of the apparatus main body 2
Face is equipped with the graduation mark for being surrounded on upper chamber port, the angle rotated for identifying upper pressing means 1；The porous pressure head 3 is and opens
The consistent cylindrical body of bore dia, be provided on side wall it is multiple penetrate in the gap of bottom surface, which is nested in aperture and can
It moves freely, the upper end is goed deep into upper chamber, and lower end is goed deep into Specimen Room 5；Pressing means 1 are located at the apparatus main body 2 on this
Upper chamber in, be connected through a screw thread with apparatus main body 2, can be moved down by rotation to contact porous 3 upper end of pressure head, and be led to
It crosses and squeezes porous 3 synchronizing moving of pressure head；The lower pressing means 6 are located at the bottom chamber of the apparatus main body 2, logical with apparatus main body 2
Threaded connection is crossed, is moved up and down by rotating realization, comes fixed preparation bottom end.The device by that X-ray material can be made thoroughly, the material
Material can be any one or more in polymethyl methacrylate, polycarbonate, polystyrene, polyformaldehyde, polyether-ether-ketone.On
Contain 4 injection hole (not shown) of a contrast agent on chamber, contrast agent 4 is injected by the hole.The present apparatus applies different journeys to cartilage
The compressive deformation of degree obtains contrast agent in endochondral distributed image by CT scan, obtains cartilage infiltration by image analysis
Property parameter.Device is reliable, easy to operate, can measure the cartilage permeability under different compact models.
Using above-mentioned cartilage permeability measurement apparatus, cartilage permeability measurement method proposed by the present invention is realized, be into one
Step illustrates this method, three application examples particularized below, and whole process is as shown in Figure 2.
Application example one: the cartilage permeability under naturally osmotic state
1. bone cartilage column sample is fixedly placed in Specimen Room, pressing means withstand sample lower end and are fixed under rotating, and protect
It demonstrate,proves cartilage surface edge and main body sleeve is in close contact, only manifest central part cartilage surface.Porous pressure head is put into aperture, bottom surface
Sample cartilage surface is contacted, injection contrast agent does not need the upper porous pressure head of pressing means rotating contact to apply extra load, guarantee
Porous pressure head and cartilage surface gentle touchdown.
2. it is intracavitary that the present apparatus is integrally put into CT scan, with 0 minute, 30 minutes, 1 hour, 2 hours, 3 hours, 5 hours, 7
The time interval of hour is scanned.
3. the picture of each time point scanning carries out gray scale-radiography agent content correlation conversion, specific region interimage is obtained
Agent content changes numerical value, and Permeability Parameters are calculated.
Application example two: the cartilage permeability under continued compression state
1. bone cartilage column sample is fixedly placed in Specimen Room, pressing means withstand sample lower end and are fixed under rotating, and protect
It demonstrate,proves cartilage surface edge and main body sleeve is in close contact, only manifest central part cartilage surface.Porous pressure head is put into aperture, bottom surface
Sample cartilage surface is contacted, contrast agent is injected, upper pressing means are rotated by a certain angle according to scale mark, to squeeze porous pressure
Head makes exposed cartilage surface that compressive deformation occur, and pressing means are motionless in holding, to maintain cartilage compressive deformation.
2. it is intracavitary that the present apparatus is integrally put into CT scan, with 0 minute, 30 minutes, 1 hour, 2 hours, 3 hours, 5 hours, 7
The time interval of hour is scanned.
3. the picture of each time point scanning carries out gray scale-radiography agent content correlation conversion, specific region interimage is obtained
Agent content changes numerical value, and Permeability Parameters are calculated.
Application example three: circulation osmosis
1. bone cartilage column sample is fixedly placed in Specimen Room, pressing means withstand sample lower end and are fixed under rotating, and protect
It demonstrate,proves cartilage surface edge and main body sleeve is in close contact, only manifest central part cartilage surface.Porous pressure head is put into aperture, bottom surface
Sample cartilage surface is contacted, contrast agent is injected, upper pressing means are rotated by a certain angle according to scale mark, to squeeze porous pressure
Head makes exposed cartilage surface that compressive deformation occur, and pressing means are motionless in holding, to maintain cartilage compressive deformation.
2. the present apparatus is integrally put into, CT scan is intracavitary to be scanned, and after 30 minutes, keeps present apparatus entirety placement position
Constant, pressing means in reverse rotation separate porous pressure head with cartilage surface, and cartilage compressive deformation disappears, and cartilage surface restores original
Highly, CT scan is carried out again at this time；After 30 minutes, pressing means are screwed again to certain angle, compress cartilage surface
Deformation, carries out CT scan at this time；It screws, discharge 6-8 times repeatedly, carry out CT scan every time
3. the picture of each time point scanning carries out CT value-radiography agent content correlation conversion, specific region interimage is obtained
All time point datas are summarized to obtain the radiography agent content of different time, certain depth by agent content distribution values, the data into
One step can be calculated the parameters such as permeability and infiltration coefficient.
This method data processing is easy, is converted directly into contrast agent content value according to standard curve by image CT value, does not have
Extra intermediate variable is introduced, requirement of the present apparatus to permeability real-time measurement can be met, rapidly and accurately obtain permeation data.?
The two concrete outcome can be obtained on the basis of this according to permeability and infiltration coefficient calculation formula.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within principle.
Claims (9)
1. a kind of cartilage permeability measurement apparatus, which is characterized in that by X-ray material being made thoroughly, including it is apparatus main body, porous
Pressure head, upper pressing means and lower pressing means；The apparatus main body includes upper chamber, Specimen Room and lower chambers from top to bottom, the sample
To hold cartilage samples, which is connected to Specimen Room by a circular opening for room；The porous pressure head be and opening diameter one
The cylindrical body of cause, be provided on side wall it is multiple penetrate in the gap of bottom surface, which is nested in aperture and can move freely,
The upper end is goed deep into upper chamber, and lower end is goed deep into Specimen Room；Pressing means are located in the upper chamber of the apparatus main body on this, can
It moves down to contact porous pressure head upper end, and by squeezing the porous pressure head synchronizing moving；The lower pressing means are located at the device
The bottom chamber of main body, by moving up and down come fixed preparation bottom end.
2. a kind of cartilage permeability measurement apparatus as described in claim 1, which is characterized in that the material is polymethyl
Sour methyl esters, polycarbonate, polystyrene, polyformaldehyde, any one or more in polyether-ether-ketone.
3. a kind of cartilage permeability measurement apparatus as described in claim 1, which is characterized in that the upper chamber and lower chambers
Inner sidewall is equipped with screw thread, and the side wall of the upper pressing means and lower pressing means is equipped with compatible screw thread, by being threadedly engaged
Upper pressing means and lower pressing means are movably connected in upper chamber and lower chambers, by rotating to adjust pressing means and lower pressurization
The position of part.
4. a kind of cartilage permeability measurement apparatus as described in claim 1, which is characterized in that the upper surface of described device main body
Equipped with the graduation mark for being surrounded on upper chamber port, for identifying the angle of upper pressing means rotation.
5. a kind of cartilage permeability measurement apparatus as described in claim 1, which is characterized in that a radiography is contained in the upper chamber
Agent injection hole.
6. a kind of cartilage permeability measurement method, using any cartilage permeability measurement apparatus of the claims 1-5,
It is characterized in that, step includes:
Cartilage samples are placed in Specimen Room, pressing means contradict porous pressure head in movement, so that end in contact under porous pressure head
Cartilage surface, while mobile lower pressing means come the bottom of fixed preparation；
Contrast agent is injected into upper chamber, make contrast agent full of hole multiple pressure head hole and with cartilage face contact；
Pressing means move down in adjusting, squeeze porous pressure head and move down to compress cartilage surface, adjust again upper pressing means to
Upper movement, to restore cartilage deformation, and so on to realize the circulation compressive deformation of cartilage；
The cartilage permeability measurement is put into CT machine and is scanned, the contrast agent distribution under cartilage different deformation state is obtained
Image determines holding time for compressive deformation according to trace interval, realizes that cartilage compressive deformation is synchronous with CT scan and carries out,
Gray scale-contrast agent content analysis is carried out to CT image sequence according to standard curve, obtains cartilage permeability parameter.
7. a kind of cartilage permeability measurement method as claimed in claim 6, which is characterized in that the contrast agent is anionic
One of contrast agent, cationic contrast agent, neutral contrast agent.
8. a kind of cartilage permeability measurement method as claimed in claim 6, which is characterized in that the CT machine is medical and clinical CT
Or scientific research Micro-CT scanning.
9. a kind of cartilage permeability measurement method as claimed in claim 6, which is characterized in that the upper pressing means are threadedly coupled
In in the upper chamber of apparatus main body, by rotating, above pressing means are to certain angle, to keep the porous pressure head of upper pressing means extruding downward
Cartilage surface is compressed, reversely rotates upper pressing means again to original position, to restore cartilage deformation.
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| CN201910279999.0A CN110006790B (en) | 2019-04-09 | 2019-04-09 | Cartilage permeability measuring device and measuring method |
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