CN101615303A - Method for making three-dimensional visualization model of internal structure of bone - Google Patents
Method for making three-dimensional visualization model of internal structure of bone Download PDFInfo
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- CN101615303A CN101615303A CN200910069695A CN200910069695A CN101615303A CN 101615303 A CN101615303 A CN 101615303A CN 200910069695 A CN200910069695 A CN 200910069695A CN 200910069695 A CN200910069695 A CN 200910069695A CN 101615303 A CN101615303 A CN 101615303A
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Abstract
The present invention is a kind of near end of thighbone method for making three-dimensional visualization model of internal structure.This method is fixed into archetype with dried bone specimen with the transpex embedding, grinding sample section successively again, and successively scan, write down two dimensional gray image and rgb image, rebuild the high-precision three-dimensional Visualization Model that software obtains the proximal bone structure with medical 3 D again.The present invention can be applicable to the three-dimensional reconstruction of human body and all bones of animal, obtain objective, reflect the high-precision three-dimensional Visualization Model of proximal bone structure truely and completely.Can be to bone trabecular structural form, and three-dimensional bone trabecular connectivity carries out certain evaluation, and can measure to the trabecular bone structure parameter, for medical research and clinical treatment provide scientific basis.
Description
[technical field]
The present invention relates to the internal structure of bone model production method, particularly a kind ofly set up digitized method for making three-dimensional visualization model of internal structure of bone.
[background technology]
Bone trabecula is arranged in the end and cube bone (as spine) of long bone (as femur), is the main biological tissue of carrying biological tissue among the human skeletal.Because the bone of this type,, formed its special bone inner structure as the stressed complicacy of femur and the anisotropy of cancellous bone.The bone inner structure of femoral head and neck of femur is woven into netted fine and close flaggy and arranges in order, and forms: principal pressure girder, opinion power girder, inferior pressure girder, inferior tension force girder, five groups of girders of greater trochanter girder.The principal direction of stress of main load is mainly born in the girder orientation along it, and forms Ward trigonum and the fine and close sclerotin that density lowers and constitute the stringer hone lamella, and promptly important structure such as bigelow's septum has made up the heavy burden system that meets psychological need jointly.The present invention can be used for all bone structures of researching human body, understands the bone trabecula structure, and clear demonstration trabecular bone structure and trend provide three-dimensional visualization model accurately.Simultaneously, can be to bone trabecular structural form, and three-dimensional bone trabecular connectivity estimates, and can measure the trabecular bone structure parameter, thereby clinical position is offered help.
Though existing research method is various in the research of bone structure, but all have shortcoming separately: the three-dimensional reconstruction based on CT, MRI can show near end of thighbone girder arrangement trend, but because the difference of image processing mode, CT, MRI etc. have limited it bone trabecula micromechanism have been carried out clear demonstration bone, the different reasons such as susceptibility of soft tissue.And the data that this method obtained are indirect data and inevitable partial volume effect.Simultaneously, be the precision that its limited time of CT or MRI and spatial resolution have all limited model, can not truly, clearly reflect femur internal fine structure.In osteoporosis research, the methyl methacrylate that utilizes that makes a breakthrough carries out the undecalcified microtomy, the inner structure that can truly reflect bone to a certain extent, but because little, the complicated operation of specimen amount, therefore the data transformation that obtains can not reflect the overall picture of femur inner structure.
The bone trabecular imaging that appears as of micro-CT in recent years provides a kind of brand-new effective ways.The micro-CT of high spatial resolution, can carry out 3 D stereo to target rebuilds, analysis to measure tradition bone tissue norphometry mathematic(al) parameter, as TBV, bone trabecula thickness, bone trabecula space length etc., thus can be comprehensively, the change of solid, real-time observation bone mass.But micro-CT is mainly used in the research to biopsy sample and toy at present, owing to can only very little area-of-interest be scanned, obtains narrow data.Simultaneously, also limited its application in human body in order to obtain the necessary roentgen radiation x of high resolving power.
[summary of the invention]
The objective of the invention is in order to overcome the deficiencies in the prior art, and provide a kind of near end of thighbone method for making three-dimensional visualization model of internal structure, this method is different from the three-dimensional reconstruction of thinking toward based on CT, MRI view data, have higher precision and accuracy, can reproduce the near end of thighbone inner structure truly, three-dimensional visualization model accurately is provided.
The present invention be address the above problem the scheme that is adopted be the design a kind of near end of thighbone method for making three-dimensional visualization model of internal structure.The method is characterized in that dried bone specimen is fixed into archetype with the transpex embedding, grinding sample section successively again, and successively scan, write down two dimensional gray image and rgb image, rebuild the high-precision three-dimensional Visualization Model that software obtains the proximal bone structure with medical 3 D again.
The invention has the beneficial effects as follows: the high precision face grinder in the application machine manufacturing of the present invention carries out grinding to the human femur near-end model through special processing with 50 μ m/ bed thickness, femur model after adopting scanner to grinding scans, obtain high precision, two-dimensional ct image (colour and gray scale) clearly, utilize advanced Mimics medical 3 D to rebuild software again and carry out three-dimensional reconstruction.With the BMP image overlay, and carry out threshold value cutting, region growing is cut apart, manual operations etc., finally can obtain objective, reflect the high-precision three-dimensional Visualization Model of near end of thighbone structure truely and completely.Can be to bone trabecular structural form, and three-dimensional bone trabecular connectivity carries out certain evaluation, and can measure the trabecular bone structure parameter.The present invention can be applicable to the three-dimensional reconstruction of human body and all bones of animal, and high-precision three-dimensional Visualization Model accurately is provided, for medical research and clinical treatment provide scientific basis.
[description of drawings]
Fig. 1 is a proximal bone method for making three-dimensional visualization model of internal structure schematic flow sheet;
Fig. 2 is a view above the near end of thighbone three-dimensional visualization model;
Fig. 3 is a near end of thighbone three-dimensional visualization model view profile;
Fig. 4 is a near end of thighbone part bone trabecula three-dimensional visualization model view;
Be described in detail with reference to accompanying drawing below in conjunction with embodiments of the invention.
[embodiment]
As shown in Figure 1, near end of thighbone method for making three-dimensional visualization model of internal structure of the present invention can may further comprise the steps:
(1) makes the bone model sample: use the polymethylmethacrylate box body as dried bone specimen container, in container, dried bone is carried out embedding, make bone model with fast dental basse acrylic resin liquid with fixed attention and self-curing denture acrylic;
(2) grinding sample: the femur model after using surface grinding machine to embedding, with the grinding successively of every layer of 10-50 μ m thickness, and the cleaning chip;
(3) successively scan and write down sample section two dimensional gray image and rgb image, its precision is 600*600DPI, and pixel is 3000*3000;
(4) three-dimensional reconstruction: image is imported Mimics, AMIRA or Imageware Surfacer software carries out three-dimensional reconstruction, obtain high precision bone trabecula three-dimensional visualization model.
Embodiment 1
1, the present invention chooses and dies from cardiovascular disease woman corpse one side femur and prepare dried bone, vertically intercepts long 150mm sample near end of thighbone, and measures its apparent parameter.
2, get length of side 120mm, the rectangular parallelepiped polymethylmethacrylate box body of high 250mm is as dried bone specimen container, and dried bone specimen container below is fixed on the cast iron base by bonding and Kirschner wire.Promptly make bonding agent, the bottom strong bond of box body on the identical square casting pig in cross section, simultaneously also between the bottom and casting pig of box body, is intersected the Kirschner wire of squeezing into many (for example 1-3 props up) diameter 2mm, strengthen fixing with methenyl choloride.The Kirschner wire that is used for the orthopaedics internal fixation, general diameter is grown about 20 centimeters at the 0.5-2 millimeter.The present invention. locate about the 15mm of distance sample bottom with the rechargeable hand drill electric drill of Maktec, intersect along vertical femur y direction and squeeze into long 90mm, diameter 2mm Kirschner wire is with the bottom and the casting pig of fixed container.
3, will coagulate dental basse acrylic resin liquid and self-curing denture acrylic then soon and be in harmonious proportion, pour into above-mentioned box body, and be opposite to wherein dried bone specimen and carry out embedding and fix, make human femur near-end sample.Should there be the 15mm distance bottom of dried bone specimen apart from the box body bottom.
4, with sample with the grinding of M618 surface grinding machine with horizontal spindle and rectangular table, its grinding accuracy can reach 10 μ m, considers the bone trabecula actual (real) thickness, with 50um/ layer grinding sample section successively, uses hair-dryer cleaning sample after the grinding.
5, adopt BENQ 5550T scanner, every layer of sample section scanned and record, obtain big or small 5*5 inch with the 600DPI scanning resolution, pixel 3000*3000, the two dimensional gray image of gray level 8bit and big or small 5*5 inch, pixel 3000*3000,24 rgb images.
6, use medical 3 D to rebuild software Mimics and carry out three-dimensional reconstruction, obtain high precision near end of thighbone bone trabecula three-dimensional visualization model.
The model of the femur inner structure that Fig. 2, Fig. 3 the present invention of being shown in Figure 4 obtains after with the said method three-dimensional reconstruction.On scheming, can clearly find out the out of shape and distribution situation of near end of thighbone bone trabecula, the bone trabecula three-D space structure.
Claims (6)
1, a kind of near end of thighbone method for making three-dimensional visualization model of internal structure, it is characterized in that dried bone specimen is fixed into archetype with the transpex embedding, grinding sample section successively again, and successively scan, write down two dimensional gray image and rgb image, rebuild the high-precision three-dimensional Visualization Model that software obtains the proximal bone structure with medical 3 D again.
2, near end of thighbone method for making three-dimensional visualization model of internal structure according to claim 1 is characterized in that said method comprising the steps of:
(1) makes the bone model sample: use the polymethylmethacrylate box body as dried bone specimen container, in container, dried bone is carried out embedding, make bone model with fast dental basse acrylic resin liquid with fixed attention and self-curing denture acrylic;
(2) grinding sample: the femur model after using surface grinding machine to embedding, with the grinding successively of every layer of 10-50 μ m thickness, and the cleaning chip;
(3) successively scan and write down sample section two dimensional gray image and rgb image, its precision is 600*600DPI, and pixel is 3000*3000;
(4) three-dimensional reconstruction: image is imported Mimics, AMIRA or Imageware Surfacer software carries out three-dimensional reconstruction, obtain high precision bone trabecula three-dimensional visualization model.
3, near end of thighbone method for making three-dimensional visualization model of internal structure according to claim 1 and 2 is characterized in that described dried bone specimen container below is fixed on the cast iron base by bonding and Kirschner wire.
4, near end of thighbone method for making three-dimensional visualization model of internal structure according to claim 1, the thickness that it is characterized in that described grinding successively are every layer 50 μ m.
5, near end of thighbone method for making three-dimensional visualization model of internal structure according to claim 1 is characterized in that described scanning use BENQ 5550T scanner.
6, near end of thighbone method for making three-dimensional visualization model of internal structure according to claim 1 is characterized in that described three-dimensional reconstruction software is Mimics software.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101964155A (en) * | 2010-09-16 | 2011-02-02 | 南方医科大学 | Method for manufacturing anthropotomy cast specimen model |
| CN102651145A (en) * | 2012-04-06 | 2012-08-29 | 哈尔滨工业大学 | Three-dimensional femoral model visualization method |
| CN102940530A (en) * | 2012-11-16 | 2013-02-27 | 昆明医科大学第一附属医院 | Method for virtually building anterior cruciate ligament on femur and tibia tunnels |
| CN102973334A (en) * | 2012-12-24 | 2013-03-20 | 天津大学 | Bionic design method of skull tissue engineering scaffold |
| CN103520771A (en) * | 2013-10-23 | 2014-01-22 | 北京纪元联合生物技术有限公司 | Method for engraving (three-dimensional) bionic artificial bones in compound bioactive material microdomains |
| CN109461200A (en) * | 2019-01-11 | 2019-03-12 | 大连大学附属中山医院 | A kind of bone internal jugular vein-arteries display methods |
| CN110542364A (en) * | 2018-12-15 | 2019-12-06 | 嘉思特华剑医疗器材(天津)有限公司 | Method for measuring wire diameter and aperture of 3D titanium alloy bone trabecula test piece |
| CN110542633A (en) * | 2018-12-15 | 2019-12-06 | 嘉思特华剑医疗器材(天津)有限公司 | Measuring method for through hole rate of 3D-printed titanium alloy bone trabecula mortar cup |
| CN110542632A (en) * | 2018-12-15 | 2019-12-06 | 嘉思特华剑医疗器材(天津)有限公司 | Method for measuring sleeve through hole rate of 3D printing titanium alloy bone trabecula structure |
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2009
- 2009-07-10 CN CN200910069695A patent/CN101615303A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101964155A (en) * | 2010-09-16 | 2011-02-02 | 南方医科大学 | Method for manufacturing anthropotomy cast specimen model |
| CN102651145A (en) * | 2012-04-06 | 2012-08-29 | 哈尔滨工业大学 | Three-dimensional femoral model visualization method |
| CN102940530A (en) * | 2012-11-16 | 2013-02-27 | 昆明医科大学第一附属医院 | Method for virtually building anterior cruciate ligament on femur and tibia tunnels |
| CN102973334A (en) * | 2012-12-24 | 2013-03-20 | 天津大学 | Bionic design method of skull tissue engineering scaffold |
| CN103520771A (en) * | 2013-10-23 | 2014-01-22 | 北京纪元联合生物技术有限公司 | Method for engraving (three-dimensional) bionic artificial bones in compound bioactive material microdomains |
| CN103520771B (en) * | 2013-10-23 | 2015-04-22 | 北京纪元联合生物技术有限公司 | Method for engraving (three-dimensional) bionic artificial bones in compound bioactive material microdomains |
| CN110542632A (en) * | 2018-12-15 | 2019-12-06 | 嘉思特华剑医疗器材(天津)有限公司 | Method for measuring sleeve through hole rate of 3D printing titanium alloy bone trabecula structure |
| CN110542364A (en) * | 2018-12-15 | 2019-12-06 | 嘉思特华剑医疗器材(天津)有限公司 | Method for measuring wire diameter and aperture of 3D titanium alloy bone trabecula test piece |
| CN110542633A (en) * | 2018-12-15 | 2019-12-06 | 嘉思特华剑医疗器材(天津)有限公司 | Measuring method for through hole rate of 3D-printed titanium alloy bone trabecula mortar cup |
| CN110542364B (en) * | 2018-12-15 | 2021-07-27 | 嘉思特华剑医疗器材(天津)有限公司 | Method for measuring wire diameter and pore diameter of 3D-printed titanium alloy bone trabecula test piece |
| CN110542632B (en) * | 2018-12-15 | 2022-03-22 | 嘉思特华剑医疗器材(天津)有限公司 | Method for measuring sleeve through hole rate of 3D printing titanium alloy bone trabecula structure |
| CN110542633B (en) * | 2018-12-15 | 2022-03-22 | 嘉思特华剑医疗器材(天津)有限公司 | Measuring method for through hole rate of 3D-printed titanium alloy bone trabecula mortar cup |
| CN109461200A (en) * | 2019-01-11 | 2019-03-12 | 大连大学附属中山医院 | A kind of bone internal jugular vein-arteries display methods |
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