CN109971724B - 靶向ErbB受体家族且自表达PD-1抗体的CAR-T细胞及其用途 - Google Patents
靶向ErbB受体家族且自表达PD-1抗体的CAR-T细胞及其用途 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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CN201711461266.6A CN109971724B (zh) | 2017-12-28 | 2017-12-28 | 靶向ErbB受体家族且自表达PD-1抗体的CAR-T细胞及其用途 |
PCT/CN2018/124316 WO2019129138A1 (zh) | 2017-12-28 | 2018-12-27 | 靶向ErbB受体家族且自表达PD-1抗体的CAR-T细胞及其用途 |
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KR20220115803A (ko) * | 2019-12-13 | 2022-08-18 | 삼성바이오에피스 주식회사 | 안정한 항-pd-1 항체 약제학적 제제 |
CN111235113A (zh) * | 2020-01-21 | 2020-06-05 | 南京北恒生物科技有限公司 | 包含嵌合抗原受体的免疫细胞及其用途 |
CN112142854B (zh) * | 2020-09-18 | 2021-06-15 | 南京凯地生物科技有限公司 | 免疫调节特异性嵌合抗原受体细胞及制备方法和应用 |
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CN105153315A (zh) * | 2015-10-09 | 2015-12-16 | 重庆倍思益生物科技有限公司 | 免疫抑制受体联合肿瘤抗原嵌合受体及其应用 |
WO2017181119A2 (en) * | 2016-04-15 | 2017-10-19 | Novartis Ag | Compositions and methods for selective protein expression |
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PL3789402T3 (pl) * | 2014-11-20 | 2022-10-17 | F. Hoffmann-La Roche Ag | Terapia skojarzona składająca się z dwuswoistych cząsteczek wiążących antygen aktywujących limfocyty T oraz antagonistów wiązania osi PD-1 |
GB201513540D0 (en) * | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
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2017
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CN105153315A (zh) * | 2015-10-09 | 2015-12-16 | 重庆倍思益生物科技有限公司 | 免疫抑制受体联合肿瘤抗原嵌合受体及其应用 |
WO2017181119A2 (en) * | 2016-04-15 | 2017-10-19 | Novartis Ag | Compositions and methods for selective protein expression |
Non-Patent Citations (3)
Title |
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Antibody-modified T cells:CARs take the seat for hematologic malignancies;Maus MV等;《Blood》;20141231;第123卷;第2625-2635页 * |
嵌合抗原受体T细胞肿瘤免疫治疗的风险与对策;张苗苗等;《药学学报》;20160712(第07期);第1032-1038页 * |
靶向EGFR家族成员分泌PD-1抗体的CAR-T细胞治疗肺癌的实验研究;胥阶英;中国优秀硕士学位论文全文数据库 医药卫生科技辑(第第7期期);E072-106 * |
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