CN109966407B - Vitality-cultivating and liver-nourishing pill - Google Patents

Abstract

The invention relates to a vitality-cultivation liver-nourishing pill for improving infertility constitution, which solves the problem of infertility caused by liver and kidney deficiency. The active ingredients of the pharmaceutical composition are prepared from the following raw materials in percentage by weight: 17-22 parts of prepared rehmannia root, 14-17 parts of dogwood, 19-23 parts of Chinese wolfberry, 14-18 parts of semen cuscutae, 14-18 parts of salted eucommia bark, 13-16 parts of rhizoma polygonati preparata, 13-16 parts of angelica sinensis, 14-16 parts of salvia miltiorrhiza, 18-21 parts of Chinese yam, 16-22 parts of poria cocos, 17-21 parts of glossy privet fruit, 18-22 parts of eclipta alba, 19-22 parts of epimedium, 15-18 parts of cistanche and 9-14 parts of radix achyranthis bidentatae. The medicine has obvious curative effect on the infertility caused by liver and kidney deficiency, and in case statistics of taking the medicine only for a certain time, the total number is 30, the effective rate is 80%, and the cure rate is 66.6%.

Description

Vitality-cultivating and liver-nourishing pill

Technical Field

The invention relates to a medicament for treating infertility caused by liver and kidney deficiency, in particular to a liver-nourishing and vitality-cultivating pill for improving infertility constitution.

Background

Infertility is defined medically as the absence of any contraceptive measures for one year, normal sexual life without successful pregnancy. It is mainly divided into primary infertility and secondary infertility. Primary infertility is never-pregnant; the secondary infertility is infertility after once pregnancy. According to this strict definition, infertility is a common problem, affecting approximately at least 10% to 15% of women of the reproductive age. The causes of infertility are classified into male infertility and female infertility.

Liver yin deficiency, also known as liver yin deficiency, refers to the transformation of fire from emotional distress and qi stagnation; or the liver-yin is damaged in the later stage of warm diseases; or the internal heat disturbing the liver due to yin deficiency of liver caused by kidney yin deficiency and water failing to nourish wood. The symptoms include dizziness and tinnitus, dry eyes, hypopsia, face fever or red cheeks, dry mouth and throat, dysphoria with smothery sensation in the chest, tidal fever and night sweat, or hypochondrium hidden burning pain, or hand and foot wriggling, etc. It is mainly indicated for nourishing yin and liver. In traditional Chinese medicine, the liver and kidney are homologous, also called as "homologous source of B and C" and "homologous source of essence and blood", namely, liver stores blood, kidney stores essence, essence can generate blood, and blood can transform essence. Kidney essence and liver blood nourish one another and vice versa. Liver pertains to wood, kidney pertains to water, and kidney water can nourish liver wood, and kidney yin is the root of yin fluid of the whole body, so kidney yin deficiency, water failing to nourish wood, can lead to liver yin deficiency, thus leading to liver yin deficiency. Infertility due to kidney deficiency is a female physical symptom, and women with the symptom are mainly lack of balance, insufficient kidney essence, incapability of pressing and pressing the sex-stimulating hormone for a certain time or a certain time without excess, deficiency of thoroughfare and conception vessels, malnutrition of uterus vessels and incapability of controlling essence to become pregnant.

The problems of infertility and infertility are increasingly highlighted along with serious environmental pollution, accelerated life rhythm, increased working pressure, change of dietary structure and transformation of fertility concept. The incidence rate of infertility in China is about 15%, and 60% of infertility is caused by female factors, which seriously affects physical and mental health of patients and causes a plurality of social problems. Therefore, how to improve the conception rate is of great interest. The development of modern reproductive medicine brings good news to many infertile patients and families. However, the modern medical technology has some problems, such as the existing hormone therapy, large side effect, low conception rate, high cost and difficult patient to insist on taking the medicine. Traditional Chinese medicine systematically studies physiological and pathological characteristics of women from a macroscopic view, and has the characteristics and advantages of integral conditioning, small adverse reaction and good long-term curative effect. Therefore, the exploration of the prescription which has definite clinical curative effect, is safe, reasonable and scientific and is easy to be accepted by the patients is imperative.

Disclosure of Invention

In order to overcome the defects in the prior art, the invention provides a Chinese medicinal composition for tonifying liver and kidney, regulating menstruation and helping pregnancy; the liver nourishing pill for improving the infertility constitution mainly treats infertility, irregular menstruation, premature ovarian failure and various symptoms before and after menopause caused by liver and kidney deficiency.

The technical scheme adopted by the invention for solving the technical problems is as follows: the effective components of the medicine composition are prepared from the following raw materials in parts by weight: 17-22 parts of prepared rehmannia root, 14-17 parts of dogwood, 19-23 parts of Chinese wolfberry, 14-18 parts of semen cuscutae, 14-18 parts of salted eucommia bark, 13-16 parts of rhizoma polygonati preparata, 13-16 parts of angelica sinensis, 14-16 parts of salvia miltiorrhiza, 18-21 parts of Chinese yam, 16-22 parts of poria cocos, 17-21 parts of glossy privet fruit, 18-22 parts of eclipta alba, 19-22 parts of epimedium, 15-18 parts of cistanche and 9-14 parts of radix achyranthis bidentatae.

The more preferable formula comprises 19-21 parts of prepared rehmannia root, 15-16 parts of dogwood, 19-21 parts of medlar, 15-18 parts of dodder, 14-15 parts of salted eucommia bark, 13-15 parts of rhizoma polygonati preparata, 15-16 parts of angelica, 15-16 parts of salvia miltiorrhiza, 19-20 parts of Chinese yam, 19-22 parts of tuckahoe, 19-21 parts of glossy privet fruit, 20-22 parts of eclipta alba, 19-20 parts of longspur epimedium, 15-16 parts of cistanche and 9-12 parts of achyranthes root.

The raw material medicaments are used as active ingredients and are prepared into pills through processing. Or the use: decocting in cold water for 20 min, and taking decoction warm after meal.

In the formula, cooked rehmannia root, radix rehmanniae is sweet, warm and moist in nature, and is a monarch drug for replenishing blood, nourishing yin, replenishing vital essence and filling marrow; cornus officinalis, sweet and neutral, can invigorate the spleen, strengthen the kidney and replenish vital essence; the medlar is sweet and mild, and can nourish liver and kidney, replenish vital essence and improve eyesight; dodder seed, sweet and mild, is the essential drug for pacifying liver, spleen and kidney, and can tonify kidney, secure essence, benefit liver, improve eyesight, invigorate spleen and stop diarrhea; the salt eucommia bark is pungent and warm, and can tonify liver and kidney, strengthen bones and muscles and prevent miscarriage; the alcohol-processed polygonatum rhizome is sweet and neutral in nature and taste, enters spleen, kidney and lung channels, and has the functions of tonifying qi and spleen, moistening lung and tonifying kidney. Dogwood, medlar, dodder, salt eucommia bark and polygonatum sibiricum wine are used as ministerial drugs to assist monarch drugs to strengthen the tonifying effect of the dogwood, the medlar, the dodder, the salt eucommia bark and the polygonatum sibiricum wine to treat the root, the liver and the kidney are tonified together to obtain the homology of the liver and the kidney and the mutual generation of essence and blood; chinese angelica, sweet, pungent and warm, can nourish liver blood and regulate menstruation; salvia miltiorrhiza, bitter in taste and slightly cold in nature, is good at promoting blood circulation, removing blood stasis and regulating menstruation; angelica and salvia serve as adjuvant medicines to promote blood circulation and regulate menstruation so as to treat the symptoms; chinese yam, sweet and neutral, can invigorate spleen, tonify lung and strengthen kidney; tonifying the three zang organs; poria cocos, sweet and bland, can excrete dampness with bland property; so that the acquired qi and blood can be actively generated; fructus Ligustri Lucidi and Ecliptae herba for nourishing liver and kidney; herba Epimedii and Cistanchis herba have effects of warming kidney and tonifying yang; achyranthes bidentata: bitter, sour and neutral. Enter liver and kidney meridians, tonify liver and kidney, strengthen tendons and bones, dispel blood stasis and dredge meridians, and draw blood downward. The medicines are combined to treat both symptoms and root causes, tonify and act simultaneously, tonify without stagnation and move without dispersion. Has the functions of tonifying liver and kidney, regulating menstruation and helping pregnancy.

Modern pharmacological research shows that most of traditional Chinese medicines with the function of promoting the gonad are traditional Chinese medicines for tonifying the kidney and replenishing the essence. According to experimental research data on the influence of kidney-tonifying medicines on the ovarian function and endometrium in recent years, Zhang Xiaohong and the like, the kidney-tonifying traditional Chinese medicine has hormone-like effect on the ovarian function and the endometrium and can adjust the function of the ovarian axis of the hypothalamus and pituitary; follicle growth promotion and ovulation promotion; regulating the levels of relevant cytokines and their receptors; globally modulating sex hormone and its receptor levels; improve the endometrial pregnancy promotion and the like, thereby further explaining that the traditional Chinese medicine for tonifying the kidney has the curative effect on the recovery of the ovarian function and the improvement of the endometrial condition. The dodder has estrogen-like effect, can regulate gonadal axis, promotes ovary corpus luteum function, has the most obvious effect of increasing uterus weight and making vaginal epithelium cornification; the Corni fructus extract can improve secretion of hypothalamic corticotropin releasing hormone of animals with kidney yang deficiency, and regulate hypothalamic-pituitary-adrenal cortex axis function; the angelica can promote uterine development and ensure normal menstrual period; fructus Lycii can increase weight of pituitary and ovary, improve neuroendocrine regulation, and induce ovulation.

The invention has the following beneficial effects: a plurality of clinical pharmacological studies show that the kidney-tonifying traditional Chinese medicine has important functions of regulating menstruation, promoting ovulation, assisting pregnancy and promoting early embryonic development. Women take the liver as the innate origin, and treatment of gynecological diseases from the liver is also an important link. The book of Ling Shu & Jing Mai (Ling Shu & Jing Mai) is characterized by: the liver meridian circulates the thigh yin, enters the hair, circulates the yin apparatus, and reaches the lower abdomen, the liver meridian goes through the lower abdomen and the yin apparatus, which also indicates that the liver is closely related to the reproductive and gynecological diseases. Therefore, the medicament for tonifying liver and kidney, regulating menstruation and helping pregnancy is clinically selected to treat infertility, and the good effect is obtained.

Detailed Description

The optimal clinical medication time of the medicine is that the medicine is started on the 5 th day of menstruation and is continuously taken for 8-10 days.

Example 1

The effective components of the medicine composition are prepared from the following raw materials in parts by weight: 19 g of prepared rehmannia root, 16 g of dogwood, 19 g of medlar, 18 g of dodder, 14 g of salted eucommia bark, 15g of rhizoma polygonati preparata, 15g of angelica, 16 g of salvia miltiorrhiza, 19 g of yam, 22 g of tuckahoe, 19 g of glossy privet fruit, 20g of eclipta alba, 19 g of longspur epimedium, 16 g of cistanche and 11 g of radix achyranthis bidentatae.

Typical case 1, plum XX, Yunnan Pu ' er people, initial diagnosis in 3 months and 23 days in 2015, 28 years old, diagnosis for patients with ' non-contraception and non-pregnancy for more than two years ', patients are ready to be pregnant since the plain menstruation rule is described, no two places live, sexual life is normal, and non-contraception is not pregnant till now in 2013. Gynecological examination: the vulva is married, the vagina is unobstructed, the cervix is slightly eroded, and the pain of the vulva is not raised. The uterus is in the front position without tenderness, and the two attachments are obviously normal. And (3) diagnosis: infertility (liver and kidney deficiency).

In 2015, from 3 and 23 days, 6 doses of the prescription are taken, the repeated diagnosis is performed at intervals of 7-15 days, more than twenty times of the repeated diagnosis are accumulated in the middle, and 6 doses of the medicinal materials of the prescription are taken each time, and the application method is as follows: soaking in cold water for 30 min, decocting for 20 min, decocting twice, collecting 600ml juice, 1 time taking 200ml, 1 day taking 3 times, and warm taking after meal. The last time of taking the medicine is that the patient is retested in 2015 for 12 and 25 days, the medical history is as before, the patient does not move in 5 days of menstruation, the patient feels dull pain in the lower abdomen, the patient has contraception in nearly one month, the tongue is red, the coating is thin, and the pulse is thready and smooth.

The patient is retested in 2016, 1 month and 4 days, the medical history is as before, the menstruation is delayed for half a month and the patient does not walk, the urine pregnancy test is positive, the tongue is red, the coating is thin, and the pulse is thready and smooth. And (3) diagnosis: early pregnancy, stop taking the medicine. Telephone follow-up: baby girl 1 was born by caesarean section on day 28/8/2016.

Example 2

The effective components of the medicine composition are prepared from the following raw materials in parts by weight: 20g of prepared rehmannia root, 20g of Chinese yam, 15g of dogwood, 15g of Chinese angelica, 15g of salted eucommia bark, 20g of poria cocos, 15g of Chinese dodder seed, 20g of medlar, 15g of salvia miltiorrhiza, 20g of glossy privet fruit, 20g of eclipta alba, 15g of polygonatum sibiricum, 20g of epimedium herb, 15g of cistanche and 12g of achyranthes bidentata.

Typical case 2, Tan XX, Pu ' er city forest Bureau, initial diagnosis in 2016, 7 and 28 days, and diagnosis in 29 years, wherein patients have irregular self-describing menstruation and 40-60 days of menstruation period due to the fact that the patients ask for diagnosis in ' three years without contraception '; before the first time, 1 woman infant delivered by cesarean section is ready to carry a second fetus in 2013, the woman infant has no two-place living, normal sexual life and no contraception to date, ovulation is monitored in an outer hospital to show that follicular dysplasia, endometrium is thin, and the treatment effect is poor after the traditional Chinese medicine and the western medicine are taken for many times. B ultrasonic monitoring and displaying: the right side ovary scrotum sample is changed, no follicle is developed, urine test is negative, the intima is 0.3cm, and five doses of the liver-nourishing pill for opening culture are used: soaking in cold water for 30 min, decocting for 20 min, decocting twice, collecting 600ml juice, 1 time taking 200ml, 1 day taking 3 times, and warm taking after meal. During the period, the application medicine is taken for more than ten times of the repeated diagnosis, the repeated diagnosis is carried out by 11 months and 4 days in 2016, and the follicle is monitored by 3 days in 11 months: right follicle 1.8cm by 1.6cm, intima 0.68cm, follicle monitored on the day of the double visit: discharged, the inner membrane is 0.8 cm. Then, the patient is prescribed 6 pills for nourishing liver and the patient is in the same room.

And (3) carrying out a re-diagnosis in 12 and 2 days in 2016, carrying out a self-test urine pregnancy test on the 11 and 20 days, and carrying out B-mode ultrasonography on the day of the re-diagnosis: 5+ week of intrauterine pregnancy, diagnosis of early pregnancy, and stopping taking the medicine. Telephone follow-up, born by caesarean section 1 boy infant 7, 11 months in 2017.

Example 3

The effective components of the medicine composition are prepared from the following raw materials in parts by weight: 21 g of prepared rehmannia root, 15g of dogwood, 21 g of medlar, 16 g of dodder, 15g of salted eucommia bark, 14 g of polygonatum kingianum, 16 g of angelica, 15g of salvia miltiorrhiza, 19 g of yam, 19 g of tuckahoe, 21 g of glossy privet fruit, 21 g of eclipta alba, 19 g of longspur epimedium, 16 g of cistanche and 11 g of achyranthes root.

Typical case 3, warm XX, Pu' er water in China, early diagnosis in 17 months in 2017, 28 years old, non-contraceptive and non-pregnant for one year, five days in menstrual period, gradual reduction of menstrual flow in the last half year, menstruation at the last time: in 2017, in 5 months and 2 days, the menstruation volume is low, the color is dark red, blood clots are clamped, the lower abdomen is sore and aching in the waist, pregnancy is prepared in 2016, no two places live in, and the sexual life is normal. The current symptoms are as follows: soreness and pain of the waist, normal leukorrhagia, clear stool, red and slightly flat tongue with little coating, and thready pulse. And (3) diagnosis: for infertility (liver and kidney deficiency), five pairs of liver-nourishing pills are prepared and decocted in a bag. During the period, the medicine is taken for more than twenty times, soaked in cold water for 30 minutes, boiled for 20 minutes, decocted twice and packaged, one dose is taken every day, 3 times per day, and the medicine is taken orally once in one bag.

And (3) performing a double-diagnosis in 2018 in 2-month and 27-day, wherein the patients have failed menstruation in 2-month and 14-day, the self-test urine pregnancy test is weak positive, and the double-diagnosis day is used for examining B-ultrasonography: intrauterine pregnancy 6+ week, diagnosis: early pregnancy, stop taking the medicine. 5, month 16 in 2018, telephone follow-up: no discomfort. B ultrasonic mode: intrauterine pregnancy, single birth; fetal size was estimated at month 17+ weeks.

Typical case 4, li XX, pu' er marketed knife photo village, initial diagnosis in 2018, 4 months and 9 days, diagnosis for 33 years, patient seeking diagnosis for "non-contraceptive and non-pregnant for 2 years", and non-pregnant examination shows: bilateral oviduct blockage, no discomfort after 3 months and 1 day of 2018 in uterus-moving laparoscopic surgery, poor follicular development detection, and clomiphene taking at present. The current symptoms are as follows: the tongue is red with less coating and the pulse is slippery. And (3) diagnosis: infertility (liver and kidney deficiency). The composition is administered orally in 6 doses. During the later period, the medicine is taken twice and is bagged after decoction, one dose is taken every day for 3 times every day, one bag is taken once, the decoction is carried out by cold water, the boiling is carried out for 20 minutes, and the oral administration is carried out.

The doctor makes a double-diagnosis in 8 and 10 months in 2018, a little bleeding in the vagina appears in 29 days in 7 and 29 days, the doctor can clean the vagina in 1 day, the self-test urine pregnancy test in 9 and 8 months tests are positive, the feeling of nausea and discomfort can be found in 2 days, and the examination of B-mode ultrasonography shows that: intrauterine pregnancy 5+ week, diagnosis of early pregnancy (threatened abortion), and stopping administration of the medicine.

Except the typical diseases, the medicine has obvious curative effect on the infertility caused by liver and kidney deficiency, and in the statistics of cases treated by taking the medicine only for a certain time, the total number of 30 cases has the effective rate of 80 percent and the cure rate of 66.6 percent. The medicine treatment is deeply trusted by patients at present, attracts patients in adjacent areas and surrounding countries to come to the hospital for treatment besides the market, and receives good social benefit.

Claims (2)

1. The effective components of the medicine composition are prepared from the following raw materials in parts by weight: 17-22 parts of prepared rehmannia root, 14-17 parts of dogwood, 19-23 parts of Chinese wolfberry, 14-18 parts of semen cuscutae, 14-18 parts of salted eucommia bark, 13-16 parts of rhizoma polygonati preparata, 13-16 parts of angelica sinensis, 14-16 parts of salvia miltiorrhiza, 18-21 parts of Chinese yam, 16-22 parts of poria cocos, 17-21 parts of glossy privet fruit, 18-22 parts of eclipta alba, 19-22 parts of epimedium, 15-18 parts of cistanche and 9-14 parts of radix achyranthis bidentatae.

2. The liver-nourishing pellet as claimed in claim 1, wherein: 19-21 parts of prepared rehmannia root, 15-16 parts of dogwood, 19-21 parts of Chinese wolfberry, 15-18 parts of Chinese dodder seed, 14-15 parts of salted eucommia bark, 13-15 parts of wine-processed polygonatum rhizome, 15-16 parts of Chinese angelica, 15-16 parts of salvia miltiorrhiza, 19-20 parts of Chinese yam, 19-22 parts of poria cocos, 19-21 parts of glossy privet fruit, 20-22 parts of eclipta alba, 19-20 parts of epimedium, 15-16 parts of cistanche and 9-12 parts of radix achyranthis bidentatae.