CN109924491A - A kind of dihydromyricetin solid-state self-emulsifying material and its preparation method and application - Google Patents
A kind of dihydromyricetin solid-state self-emulsifying material and its preparation method and application Download PDFInfo
- Publication number
- CN109924491A CN109924491A CN201910255323.8A CN201910255323A CN109924491A CN 109924491 A CN109924491 A CN 109924491A CN 201910255323 A CN201910255323 A CN 201910255323A CN 109924491 A CN109924491 A CN 109924491A
- Authority
- CN
- China
- Prior art keywords
- dihydromyricetin
- solid
- emulsifying
- self
- state self
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of dihydromyricetin solid-state self-emulsifying materials and its preparation method and application, which includes following components by mass parts: 2~7 parts of dihydromyricetin, 20~43 parts of lipid components, 15~20 parts of hydrophilic surfactant active, 5~14 parts of hydrophobic surfactant, 35~60 parts of solid absorbent;Preparation method is as follows: 1) dihydromyricetin and lipid components being mixed to clarification as oily phase;2) oily phase, hydrophilic surfactant and hydrophobic surfactant are mixed to form uniform phase system;3) by uniform phase system and solid absorbent liquid dispersed in dehydrated alcohol, being sufficiently stirred, which is adsorbed on it sufficiently in solid absorbent, obtains dispersion liquid;4) dispersion liquid rotary evaporation is dispelled into dehydrated alcohol, be then ground up, sieved to obtain the final product.The material has good water-soluble and stability, and preparation process is simple controllable, reproducible, can be applied to the preparation of functional food.
Description
Technical field
The present invention relates to a kind of dihydromyricetin solid-state self-emulsifying materials and its preparation method and application, belong to functional food
Carrier system technical field in technology of preparing.
Background technique
China is the country of early start wine brewing in the world, and spirits culture is also permeated in many Social Cultures, early had become
Essential a part in daily life.However insobriety, cause alcohol to accumulate, can make all multi visceras such as liver and spleen stomach by
Damage, has become a more serious public health problem at present.So far, U.S. FDA only has approved 3 and can be used for
The oral drugs of alcoholism are treated, i.e. naltrexone, Acamprosate and support adjoins ester.But it is found in animal experiment and clinical research,
Many Chinese traditional herbs ingredients, such as hoveniae semoveniae semen, fructus lycii, pueraria lobata also show the preferable effect for improving alcoholism.Through
Constituents extraction analysis is crossed it is found that the main active that these Chinese herbal medicines play effect is mostly natural plants flavone compound,
Compared with horn of plenty and wherein there is significant physiological activity with the content of dihydromyricetin (DMY) again, Chinese Soclety of Nutrition is also recommended
Daily DMY intake is 960mg.Dihydromyricetin, also known as ampeloptin, ampelopsin, molecular formula C15H12O8, average molecular matter
Amount 320.25 is a kind of natural polyphenol hydroxyl flavanonol, belongs to flavone compound, is widely present in ampelopsis grossdentata plant
In the cauline leaf of object, content may be up to 30%.
Research confirms that dihydromyricetin can extend drunk tolerance time, and shortening is sobered up the time, plays and resists alcoholism
It is acted on alcohol dependence, there is preferable anti-intoxication alcohol neutralizing effect.Its play effect molecular mechanism at present it is believed that with
DMY can be acted on the Benzodiazepine action site on ethyl alcohol competitive binding GABAARs without Benzodiazepine sample, to inhibit
Influence of the alcohol to GABAARs is closely related.In addition, DMY also shows preferable therapeutic effect to Ethanol hepatic injury, can have
Effect reduces the level of malonaldehyde and triacylglycerol in liver, improves reduced glutathione level, mitigates hepatic cell fattydegeneration,
The effect may be by improving liver cell oxidation resistance, to inhibit membrane lipid peroxidatio caused by ethyl alcohol to realize.
But the water solubility of dihydromyricetin and fat-soluble poor and stability of molecule are poor, easily by Fe during processing and storage3+、
Al3+、Cu2+Equal metal ions, oxygen and light oxidation, and the raising of pH value and temperature can accelerate its oxidation course.Therefore,
It is significantly limited in the bioavilability and application of functional food field.
Self-emulsifying systems are made of lipid and surfactant, are generally used for load fat-soluble active ingredient, are situated between in water
The O/W nanoemulsions of partial size about 100nm can be formed in matter through gentle agitation;If directly entering in vivo by oral administration, can also disappear
Change and spontaneously forms uniform O/W nanoemulsions in aqueous medium under the creeping effect in road.Common self-emulsifying systems include liquid
With two kinds of dosage forms of solid-state.Liquid self-emulsifying systems can dramatically increase the absorption and utilization of active constituent, and determine formula group
Cheng Hou, it is only necessary to active constituent is dissolved in specific formula, preparation process very simple is suitble to large-scale production.But
Since its rouge content is higher, oral bad adaptability is often packaged applies in soft, hard capsule.In addition, liquid self-emulsifying systems are made
For a kind of liquid formulation will necessarily exist as between liquid active ingredient interaction, between active constituent and auxiliary material and capsule shells
The limiting factors such as interaction, low-temperature precipitation, inconvenient to carry and stability is poor.Therefore, liquid is adsorbed using solid absorbent
Self-emulsifying systems in conjunction with freeze-drying, spray drying, solvent evaporation, squeeze out the-different drying means such as round as a ball, so that it may
Controllable solidification liquid self-emulsifying systems, obtain solid-state self-emulsifying systems.In the high load that reservation liquid self-emulsifying systems have
While the advantage of amount and bioavilability, defect existing for liquid preparation is overcome.
Summary of the invention
Technical problem: the object of the present invention is to provide a kind of dihydromyricetin solid-state self-emulsifying material and preparation method thereof and
Using carrying out package processing to dihydromyricetin using solid-state self-emulsifying systems, prepare a kind of two applied in functional food
Hydrogen myricetin solves low-solubility, low stability and low bioavilability of dihydromyricetin etc. using bottleneck, makes it preferably
Move towards commercialization process.
Technical solution: the present invention provides a kind of dihydromyricetin solid-state self-emulsifying materials, and the material is according to mass parts packet
Include following components:
Wherein:
The lipid components are linseed oil, Miglyol 812N, olive oil, coconut oil, grape seed oil, Australia heavily fortified point
One of fruit oil, sunflower oil, camellia seed oil or corn oil are a variety of.
The hydrophilic surfactant active is polysorbas20, polysorbate40, polysorbate60, Tween 80, six polyglycerol monooleates, ten
One of polyglycerol monooleate, six polyglycereol monolaurates or ten polyglycereol monolaurates are a variety of.
The hydrophobic surfactant be polyglycerol polyricinoleate, polyglycerol monooleate, ten polyglycereol, ten oleate,
Any one in span 40, sorbester p18 or sorbester p17.
The solid absorbent is silica, calcium phosphate dibasic anhydrous, porous-starch, maltodextrin, PVP K30, low
Replace any one in hydroxypropyl cellulose or microcrystalline cellulose.
The partial size that the dihydromyricetin solid-state self-emulsifying material is dispersed in micro emulsion formed in aqueous medium is less than
500nm。
The present invention also provides a kind of preparation method of dihydromyricetin solid-state self-emulsifying material, this method includes following step
It is rapid:
1) it is stirred at room temperature to solution to become after in proportion mixing dihydromyricetin and lipid components and be clarified, as oil
Phase;
2) oily phase, hydrophilic surfactant and hydrophobic surfactant are thoroughly mixed to form in room temperature in proportion
One phase obtains dihydromyricetin liquid self-emulsifying systems;
3) by dihydromyricetin liquid self-emulsifying systems and solid absorbent liquid dispersed in dehydrated alcohol, at room temperature
It is sufficiently stirred, is adsorbed on dihydromyricetin liquid self-emulsifying systems sufficiently in solid absorbent, obtain dihydromyricetin solid-state certainly
Emulsification system alcohol dispersion liquid;
4) dihydromyricetin solid-state self-emulsifying systems alcohol dispersion liquid rotary evaporation is dispelled into dehydrated alcohol, it is then ground
It sieves up to dihydromyricetin solid-state self-emulsifying material.
Wherein:
In proportion by dihydromyricetin liquid self-emulsifying systems and solid absorbent liquid dispersed in nothing described in step 3)
In water-ethanol, the mass parts ratio of dihydromyricetin liquid self-emulsifying systems and solid absorbent is 45~65 parts: 35~55 parts.
The temperature of rotary evaporation process described in step 4) is 40 DEG C~50 DEG C;Described is then ground up, sieved up to dihydro
In myricetin solid-state self-emulsifying material, refer to that dihydromyricetin solid-state self-emulsifying material passes through 60 meshes.
The present invention also provides a kind of application of dihydromyricetin solid-state self-emulsifying material, the dihydromyricetin solid-state is certainly newborn
Change the preparation that material is applied to functional food.
The utility model has the advantages that compared with prior art, present invention has the advantage that
1) present invention carries out package processing to dihydromyricetin using solid-state self-emulsifying systems, and obtained dihydromyricetin is solid
State self-emulsifying material, it is with good stability, the dissolubility of dihydromyricetin is improved, to improve its bioavilability;
2) each component has very high safety in the formula of dihydromyricetin solid-state self-emulsifying material, non-stimulated to body
Property, non-toxic, can be used as nutritional additive is used in compounding with food formula, and compatibility is good, can be widely used for functional food field;
3) preparation method is simply controllable, reproducible.
Detailed description of the invention
Fig. 1 is the preparation method flow chart of dihydromyricetin solid-state self-emulsifying material of the present invention.
Specific embodiment
The invention will be further described with reference to embodiments.These embodiments are not limited to for illustrating the present invention
It limits the scope of the invention.Implementation condition used in the examples can do further adjustment according to the condition of specific producer.
Embodiment 1
A kind of dihydromyricetin solid-state self-emulsifying material, the partial size for being dispersed in micro emulsion formed in aqueous medium are less than 500nm,
Include following components according to mass parts:
Preparation method the following steps are included:
1) 0.6g dihydromyricetin, 6g linseed oil are weighed, after dihydromyricetin and linseed oil are mixed at room temperature
Magnetic agitation is until solution becomes clarification, as oily phase;
2) six polyglycerol monooleate of 4.5g, 2.4g sorbester p18 are weighed, by oily phase, six polyglycerol monooleates and sorbester p18
Homogeneous phase is thoroughly mixed to form after mixing in room temperature, obtains dihydromyricetin liquid self-emulsifying systems;
3) dihydromyricetin liquid self-emulsifying systems 13.5g and microcrystalline cellulose 16.5g then are weighed, by dihydromyricetin
Liquid self-emulsifying systems and microcrystalline cellulose are scattered in appropriate dehydrated alcohol, are sufficiently stirred at room temperature, and dihydromyricetin is made
Liquid self-emulsifying systems are sufficiently adsorbed in solid absorbent microcrystalline cellulose, obtain dihydromyricetin solid-state self-emulsifying systems ethyl alcohol
Dispersion liquid;
4) dihydromyricetin solid-state self-emulsifying systems alcohol dispersion liquid is dispelled into dehydrated alcohol in 40 DEG C of rotary evaporations, then
Ground 60 mesh of mistake is up to dihydromyricetin solid-state self-emulsifying material.
1.0g dihydromyricetin solid-state self-emulsifying material is added in 100g deionized water, after evenly dispersed, utilizes grain
Average grain diameter is 147.3 ± 2.4nm after degree instrument obtains dihydromyricetin solid-state self-emulsifying systems water dispersion, and 25 DEG C are placed at room temperature for 1
Its average grain diameter is 152.7 ± 3.1nm after a month, and change of size no significant difference shows that it has good stability.
Embodiment 2
The partial size that a kind of dihydromyricetin solid-state self-emulsifying material is dispersed in micro emulsion formed in aqueous medium is less than 500nm,
Include following components according to mass parts:
Preparation method the following steps are included:
1) 0.8g dihydromyricetin, 6g olive oil are weighed, magnetic force at room temperature after dihydromyricetin and olive oil are mixed
Stirring is until solution becomes clarification, as oily phase;
2) ten polyglycerol monooleate of 6g and 4.2g sorbester p18 are weighed, by oily phase, ten polyglycerol monooleates and sorbester p18
Homogeneous phase is thoroughly mixed to form after mixing in room temperature, obtains dihydromyricetin liquid self-emulsifying systems;
3) dihydromyricetin liquid self-emulsifying systems 17g and calcium phosphate dibasic anhydrous 13g then are weighed, by dihydromyricetin liquid
State self-emulsifying systems and calcium phosphate dibasic anhydrous are scattered in appropriate dehydrated alcohol, are sufficiently stirred at room temperature, and dihydromyricetin is made
Liquid self-emulsifying systems are sufficiently adsorbed in solid absorbent calcium phosphate dibasic anhydrous, obtain dihydromyricetin solid-state self-emulsifying systems second
Alcohol dispersion liquid;
4) dihydromyricetin solid-state self-emulsifying systems alcohol dispersion liquid is dispelled into dehydrated alcohol in 50 DEG C of rotary evaporations, then
Ground 60 mesh of mistake is up to dihydromyricetin solid-state self-emulsifying material.
1.0g dihydromyricetin solid-state self-emulsifying material is added in 100g deionized water, after evenly dispersed, utilizes grain
Average grain diameter is 98.5 ± 1.2nm after degree instrument obtains dihydromyricetin solid-state self-emulsifying systems water dispersion, and 25 DEG C are placed at room temperature for 1
Its average grain diameter is 101.2 ± 2.2nm after month, and change of size no significant difference shows that it has good stability.
Embodiment 3
The partial size that a kind of dihydromyricetin solid-state self-emulsifying material is dispersed in micro emulsion formed in aqueous medium is less than 500nm,
Include following components according to mass parts:
Preparation method the following steps are included:
1) 1g dihydromyricetin, 8g corn oil are weighed, magnetic force stirs at room temperature after dihydromyricetin and corn oil are mixed
It mixes until solution becomes clarification, as oily phase;
2) ten polyglycereol monolaurate of 5g and 2g polyglycerol monooleate are weighed, by oily phase, ten polyglycereol mono laurates
It is thoroughly mixed to form homogeneous phase in room temperature after ester and polyglycerol monooleate mixing, obtains dihydromyricetin liquid self-emulsifying body
System;
3) dihydromyricetin liquid self-emulsifying systems 16g and porous-starch 14g then are weighed, certainly by dihydromyricetin liquid
Emulsification system and porous-starch are scattered in appropriate dehydrated alcohol, are sufficiently stirred at room temperature, make dihydromyricetin liquid from cream
Change system is sufficiently adsorbed in solid absorbent porous-starch, obtains dihydromyricetin solid-state self-emulsifying systems alcohol dispersion liquid;
4) dihydromyricetin solid-state self-emulsifying systems alcohol dispersion liquid is dispelled into dehydrated alcohol in 50 DEG C of rotary evaporations, then
Ground 60 mesh of mistake is up to dihydromyricetin solid-state self-emulsifying material.
1.0g dihydromyricetin solid-state self-emulsifying material is added in 100g deionized water, after evenly dispersed, utilizes grain
Average grain diameter is 198.5 ± 1.2nm after degree instrument obtains dihydromyricetin solid-state self-emulsifying systems water dispersion, and 25 DEG C are placed at room temperature for 1
Its average grain diameter is 201.2 ± 2.2nm after a month, and change of size no significant difference shows that it has good stability.
Embodiment 4
The partial size that a kind of dihydromyricetin solid-state self-emulsifying material is dispersed in micro emulsion formed in aqueous medium is less than 500nm,
Include following components according to mass parts:
Preparation method the following steps are included:
1) 1.2g dihydromyricetin, 8.8g camellia seed oil are weighed, in room temperature after dihydromyricetin and camellia seed oil are mixed
Lower magnetic agitation is until solution becomes clarification, as oily phase;
2) 3g Tween 80,2g polysorbas20 and 3g span 40 are weighed, after oily phase, Tween 80, polysorbas20 and span 40 are mixed
It is thoroughly mixed to form homogeneous phase in room temperature, obtains dihydromyricetin liquid self-emulsifying systems;
3) dihydromyricetin liquid self-emulsifying systems 18g and silica 1 2g then are weighed, certainly by dihydromyricetin liquid
Emulsification system and silica are scattered in appropriate dehydrated alcohol, are sufficiently stirred at room temperature, make dihydromyricetin liquid from cream
Change system is sufficiently adsorbed in solid absorbent silica, obtains dihydromyricetin solid-state self-emulsifying systems alcohol dispersion liquid;
4) dihydromyricetin solid-state self-emulsifying systems alcohol dispersion liquid is dispelled into dehydrated alcohol in 45 DEG C of rotary evaporations, then
Ground 60 mesh of mistake is up to dihydromyricetin solid-state self-emulsifying material.
1.0g dihydromyricetin solid-state self-emulsifying material is added in 100g deionized water, after evenly dispersed, utilizes grain
Average grain diameter is 305.2 ± 5.1nm after degree instrument obtains dihydromyricetin solid-state self-emulsifying systems water dispersion, and 25 DEG C are placed at room temperature for 1
Its average grain diameter is 309.5 ± 2.4nm after a month, and change of size no significant difference shows that it has good stability.
Embodiment 5
The partial size that a kind of dihydromyricetin solid-state self-emulsifying material is dispersed in micro emulsion formed in aqueous medium is less than 500nm,
Include following components according to mass parts:
Preparation method the following steps are included:
1) 1.5g dihydromyricetin, 12g coconut oil are weighed, magnetic force at room temperature after dihydromyricetin and coconut oil are mixed
Stirring is until solution becomes clarification, as oily phase;
2) 4.5g polysorbate60 and 1.5g polyglycerol polyricinoleate are weighed, oily phase, polysorbate60 and polyglycerol polyricinoleate are mixed
Homogeneous phase is thoroughly mixed to form after conjunction in room temperature, obtains dihydromyricetin liquid self-emulsifying systems;
3) dihydromyricetin liquid self-emulsifying systems 19.5g and maltodextrin 10.5g then are weighed, by dihydromyricetin liquid
State self-emulsifying systems and maltodextrin are scattered in appropriate dehydrated alcohol, are sufficiently stirred at room temperature, and dihydromyricetin liquid is made
Self-emulsifying systems are sufficiently adsorbed in solid absorbent maltodextrin, obtain the dispersion of dihydromyricetin solid-state self-emulsifying systems ethyl alcohol
Liquid;
4) dihydromyricetin solid-state self-emulsifying systems alcohol dispersion liquid is dispelled into dehydrated alcohol in 45 DEG C of rotary evaporations, then
Ground 60 mesh of mistake is up to dihydromyricetin solid-state self-emulsifying material.
1.0g dihydromyricetin solid-state self-emulsifying material is added in 100g deionized water, after evenly dispersed, utilizes grain
Average grain diameter is 472.1 ± 0.2nm after degree instrument obtains dihydromyricetin solid-state self-emulsifying systems water dispersion, and 25 DEG C are placed at room temperature for 1
Its average grain diameter is 489.5 ± 5.4nm after a month, and change of size no significant difference shows that it has good stability.
Claims (10)
1. a kind of dihydromyricetin solid-state self-emulsifying material, it is characterised in that: the material includes following components according to mass parts:
2. a kind of dihydromyricetin solid-state self-emulsifying material as described in claim 1, it is characterised in that: the lipid components are
Linseed oil, Miglyol 812N, olive oil, coconut oil, grape seed oil, macadimia nut oil, sunflower oil, camellia seed oil
Or one of corn oil or a variety of.
3. a kind of dihydromyricetin solid-state self-emulsifying material as described in claim 1, it is characterised in that: the hydrophilic surface
Activating agent be polysorbas20, polysorbate40, polysorbate60, Tween 80, six polyglycerol monooleates, ten polyglycerol monooleates, six gather it is sweet
One of oily monolaurate or ten polyglycereol monolaurates are a variety of.
4. a kind of dihydromyricetin solid-state self-emulsifying material as described in claim 1, it is characterised in that: the hydrophobic surface
Activating agent is polyglycerol polyricinoleate, polyglycerol monooleate, ten polyglycereol, ten oleate, span 40, sorbester p18 or sapn
Any one in 80.
5. a kind of dihydromyricetin solid-state self-emulsifying material as described in claim 1, it is characterised in that: the solid absorbent
For silica, calcium phosphate dibasic anhydrous, porous-starch, maltodextrin, PVP K30, low-substituted hydroxypropyl cellulose or micro-
Any one in crystalline cellulose.
6. a kind of dihydromyricetin solid-state self-emulsifying material as described in claim 1, it is characterised in that: the dihydromyricetin
The partial size that plain solid-state self-emulsifying material is dispersed in micro emulsion formed in aqueous medium is less than 500nm.
7. a kind of preparation method of the dihydromyricetin solid-state self-emulsifying material as described in Claims 1 to 5 is any, feature exist
In: method includes the following steps:
1) it is stirred at room temperature to solution to become after in proportion mixing dihydromyricetin and lipid components and be clarified, as oily phase;
2) oily phase, hydrophilic surfactant and hydrophobic surfactant are thoroughly mixed to form in room temperature in proportion uniform
Phase obtains dihydromyricetin liquid self-emulsifying systems;
3) by dihydromyricetin liquid self-emulsifying systems and solid absorbent liquid dispersed in dehydrated alcohol, at room temperature sufficiently
Stirring, is adsorbed on dihydromyricetin liquid self-emulsifying systems sufficiently in solid absorbent, obtains dihydromyricetin solid-state self-emulsifying
System alcohol dispersion liquid;
4) dihydromyricetin solid-state self-emulsifying systems alcohol dispersion liquid rotary evaporation is dispelled into dehydrated alcohol, be then ground up, sieved i.e.
Obtain dihydromyricetin solid-state self-emulsifying material.
8. a kind of preparation method of dihydromyricetin solid-state self-emulsifying material as claimed in claim 6, it is characterised in that: step
3) described in proportion by dihydromyricetin liquid self-emulsifying systems and solid absorbent liquid dispersed in dehydrated alcohol, dihydro
The mass parts ratio of myricetin liquid self-emulsifying systems and solid absorbent is 45~65 parts: 35~55 parts.
9. a kind of preparation method of dihydromyricetin solid-state self-emulsifying material as claimed in claim 6, it is characterised in that: step
4) temperature of the rotary evaporation process described in is 40 DEG C~50 DEG C;Described is then ground up, sieved up to dihydromyricetin solid-state certainly
In emulsified material, refer to that dihydromyricetin solid-state self-emulsifying material passes through 60 meshes.
10. a kind of application of the dihydromyricetin solid-state self-emulsifying material as described in Claims 1 to 5 is any, it is characterised in that:
The dihydromyricetin solid-state self-emulsifying material is applied to the preparation of functional food.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910255323.8A CN109924491A (en) | 2019-04-01 | 2019-04-01 | A kind of dihydromyricetin solid-state self-emulsifying material and its preparation method and application |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910255323.8A CN109924491A (en) | 2019-04-01 | 2019-04-01 | A kind of dihydromyricetin solid-state self-emulsifying material and its preparation method and application |
Publications (1)
Publication Number | Publication Date |
---|---|
CN109924491A true CN109924491A (en) | 2019-06-25 |
Family
ID=66988789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910255323.8A Pending CN109924491A (en) | 2019-04-01 | 2019-04-01 | A kind of dihydromyricetin solid-state self-emulsifying material and its preparation method and application |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109924491A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112244279A (en) * | 2020-09-25 | 2021-01-22 | 东南大学 | Fullerene solid self-emulsifying material and preparation method and application thereof |
CN113966839A (en) * | 2021-10-14 | 2022-01-25 | 恒枫食品科技有限公司 | Composite emulsion containing walnut oil and dihydromyricetin and preparation method thereof |
CN115252455A (en) * | 2022-07-02 | 2022-11-01 | 堇色生物科技(中山)有限责任公司 | Dihydromyricetin nanoemulsion and preparation method and application thereof |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020102301A1 (en) * | 2000-01-13 | 2002-08-01 | Joseph Schwarz | Pharmaceutical solid self-emulsifying composition for sustained delivery of biologically active compounds and the process for preparation thereof |
CN101618020A (en) * | 2009-06-17 | 2010-01-06 | 沈阳药科大学 | Solid self-emulsifying oral administration system of dihydropyridine calcium ion antagonist and preparation method thereof |
CN105287429A (en) * | 2015-11-20 | 2016-02-03 | 河北科技大学 | Preparation method of brucea javanica oil solid self-emulsifying capsule |
CN105796512A (en) * | 2016-05-31 | 2016-07-27 | 哈尔滨商业大学 | Method for preparing dihydromyricetin solid lipid granules |
CN106667908A (en) * | 2016-12-29 | 2017-05-17 | 广州新济药业科技有限公司 | Supersaturated solid self-emulsifying preparation and preparation method thereof |
CN106727340A (en) * | 2016-12-28 | 2017-05-31 | 广州中大南沙科技创新产业园有限公司 | Solid self-emulsifying preparation and preparation method thereof |
CN107242999A (en) * | 2017-05-04 | 2017-10-13 | 方达医药技术(苏州)有限公司 | A kind of multiple self-emulsifying carrier of solid and preparation method thereof |
CN108567597A (en) * | 2018-06-28 | 2018-09-25 | 东南大学 | A kind of non-aqueous multiple self-emulsifying systems of Quercetin and its preparation method and application |
CN108670953A (en) * | 2018-06-28 | 2018-10-19 | 广东工业大学 | A kind of dihydromyricetin water-soluble nano suspending agent and its preparation method and application |
CN108814995A (en) * | 2018-06-28 | 2018-11-16 | 东南大学 | A kind of non-aqueous multiple self-emulsifying systems of rutin and its preparation method and application |
-
2019
- 2019-04-01 CN CN201910255323.8A patent/CN109924491A/en active Pending
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020102301A1 (en) * | 2000-01-13 | 2002-08-01 | Joseph Schwarz | Pharmaceutical solid self-emulsifying composition for sustained delivery of biologically active compounds and the process for preparation thereof |
CN101618020A (en) * | 2009-06-17 | 2010-01-06 | 沈阳药科大学 | Solid self-emulsifying oral administration system of dihydropyridine calcium ion antagonist and preparation method thereof |
CN105287429A (en) * | 2015-11-20 | 2016-02-03 | 河北科技大学 | Preparation method of brucea javanica oil solid self-emulsifying capsule |
CN105796512A (en) * | 2016-05-31 | 2016-07-27 | 哈尔滨商业大学 | Method for preparing dihydromyricetin solid lipid granules |
CN106727340A (en) * | 2016-12-28 | 2017-05-31 | 广州中大南沙科技创新产业园有限公司 | Solid self-emulsifying preparation and preparation method thereof |
CN106667908A (en) * | 2016-12-29 | 2017-05-17 | 广州新济药业科技有限公司 | Supersaturated solid self-emulsifying preparation and preparation method thereof |
CN107242999A (en) * | 2017-05-04 | 2017-10-13 | 方达医药技术(苏州)有限公司 | A kind of multiple self-emulsifying carrier of solid and preparation method thereof |
CN108567597A (en) * | 2018-06-28 | 2018-09-25 | 东南大学 | A kind of non-aqueous multiple self-emulsifying systems of Quercetin and its preparation method and application |
CN108670953A (en) * | 2018-06-28 | 2018-10-19 | 广东工业大学 | A kind of dihydromyricetin water-soluble nano suspending agent and its preparation method and application |
CN108814995A (en) * | 2018-06-28 | 2018-11-16 | 东南大学 | A kind of non-aqueous multiple self-emulsifying systems of rutin and its preparation method and application |
Non-Patent Citations (2)
Title |
---|
JUAN HUANG,等: "A novel solid self-emulsifying delivery system (SEDS) for the encapsulation of linseed oil and quercetin: Preparation and evaluation", 《JOURNAL OF FOOD ENGINEERING》 * |
齐娜,等: "二氢杨梅素自乳化***的设计与质量评价", 《医药导报》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112244279A (en) * | 2020-09-25 | 2021-01-22 | 东南大学 | Fullerene solid self-emulsifying material and preparation method and application thereof |
CN113966839A (en) * | 2021-10-14 | 2022-01-25 | 恒枫食品科技有限公司 | Composite emulsion containing walnut oil and dihydromyricetin and preparation method thereof |
CN113966839B (en) * | 2021-10-14 | 2024-05-14 | 恒枫食品科技有限公司 | Composite emulsion containing walnut oil and dihydromyricetin and preparation method thereof |
CN115252455A (en) * | 2022-07-02 | 2022-11-01 | 堇色生物科技(中山)有限责任公司 | Dihydromyricetin nanoemulsion and preparation method and application thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Bušić et al. | Structuring new alginate network aimed for delivery of dandelion (Taraxacum officinale L.) polyphenols using ionic gelation and new filler materials | |
CN109924491A (en) | A kind of dihydromyricetin solid-state self-emulsifying material and its preparation method and application | |
EP0142601B1 (en) | Easily dispersible dietary fiber product and method for producing the same | |
CN110301483A (en) | The purposes of fullerene compound and fullerene microcapsule powder and its preparation method and application | |
US20120171186A1 (en) | method for producing a nutraceutical composition and the nutraceutical produced by the method | |
CN101088524B (en) | Phosphatide composition of active skull cap components and prepn. process and prepn. thereof | |
AU2007305614A1 (en) | O/W/O emulsion containing lignan compounds and composition containing the same | |
CN104840430B (en) | A kind of chlorogenic acid chitosan microball and its preparation process and application | |
USRE32811E (en) | Easily dispersible dietary fiber product and method for producing the same | |
JP2818220B2 (en) | Composition containing water-containing organic solvent extract for food, composition containing water-containing organic solvent extract for medicine, and methods for producing them | |
KR20130083822A (en) | Aqueous formulation of vitamins and preparation method thereof | |
CN103251572B (en) | Preparation method of theaflavin enteric microcapsule, as well as product prepared by preparation method and application of product | |
CN107568744A (en) | Heat treatment combines the method that the processing of high pressure microjet prepares stable type soybean protein sterol particles | |
CN105341903A (en) | Edible polypeptide and fat composition and self-assembling method thereof | |
EP2099320A1 (en) | Method for producing sterol formulations | |
JP2010233559A (en) | Method for producing processed plant powder | |
AU2017322712B2 (en) | Odor masking formulations for natural compounds | |
JP5096658B2 (en) | Soft capsule with improved bioavailability | |
CN102872002B (en) | Hydroxysafflor yellow A oil solution and preparation method and application thereof | |
KR101419036B1 (en) | Manufacturing method of soft persimmon icecream | |
CN102058606B (en) | Oryzanol medicinal composition | |
CN112807277A (en) | Fat-soluble vitamin self-emulsifying composition and preparation method of preparation thereof | |
JP2000026884A (en) | Powder composition containing oily composition | |
CN117530446B (en) | Krill oil microemulsion gel bead and preparation method thereof | |
Nabilah et al. | The Effect of Nano-Polyphenols Cocoa Whey Protein as Functional Fortification Materials in Terms of Antioxidant Activity and Physicochemical Properties |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190625 |
|
RJ01 | Rejection of invention patent application after publication |