CN109865704A - Magnetic bead cleaning device suitable for in-vitro diagnosis equipment - Google Patents
Magnetic bead cleaning device suitable for in-vitro diagnosis equipment Download PDFInfo
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- CN109865704A CN109865704A CN201910284444.5A CN201910284444A CN109865704A CN 109865704 A CN109865704 A CN 109865704A CN 201910284444 A CN201910284444 A CN 201910284444A CN 109865704 A CN109865704 A CN 109865704A
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- 238000004140 cleaning Methods 0.000 title claims abstract description 86
- 239000011324 bead Substances 0.000 title claims abstract description 43
- 238000003745 diagnosis Methods 0.000 title claims abstract description 19
- 238000000338 in vitro Methods 0.000 title claims abstract description 19
- 239000007788 liquid Substances 0.000 claims abstract description 62
- 239000007924 injection Substances 0.000 claims abstract description 33
- 238000002347 injection Methods 0.000 claims abstract description 33
- 238000005086 pumping Methods 0.000 claims abstract description 25
- 239000012530 fluid Substances 0.000 claims abstract description 23
- 238000005406 washing Methods 0.000 claims abstract description 23
- 238000005213 imbibition Methods 0.000 claims abstract description 20
- 238000001179 sorption measurement Methods 0.000 claims abstract description 15
- 230000002093 peripheral effect Effects 0.000 claims abstract description 4
- 238000006243 chemical reaction Methods 0.000 claims description 28
- 239000000758 substrate Substances 0.000 claims description 11
- 238000010276 construction Methods 0.000 claims description 6
- 238000011010 flushing procedure Methods 0.000 claims description 6
- 230000007246 mechanism Effects 0.000 claims description 4
- 230000003028 elevating effect Effects 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 230000003447 ipsilateral effect Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 12
- 238000012864 cross contamination Methods 0.000 abstract description 5
- 239000002699 waste material Substances 0.000 description 16
- 238000010586 diagram Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 238000009830 intercalation Methods 0.000 description 3
- 230000002687 intercalation Effects 0.000 description 3
- 230000002452 interceptive effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000005415 bioluminescence Methods 0.000 description 1
- 230000029918 bioluminescence Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
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Abstract
The invention discloses a kind of magnetic bead cleaning devices suitable for in-vitro diagnosis equipment, including magnetic to wash component and hair washing component, and liquid pumping needle is provided in the mounting base for component of washing hair and a note one inhales cleaning combination；It includes rotating disk that magnetic, which washes component, mounting hole is offered in rotating disk, magnetic receiver is provided with below rotating disk, magnetic receiver includes connecting plate and is arranged in the outer peripheral guide groove of connecting plate, with pre- adsorption potential magnet is provided in the guiding groove sidewall of notch corresponding position, with drawing liquid position magnet is provided in the guiding groove sidewall of liquid pumping needle corresponding position, inhale cleaning with every group of note one and combine and be provided with group of magnets in the guiding groove sidewall of corresponding position.Liquid pumping needle of the present invention has self-cleaning function, and cleaning effect is good, avoids different sample cross contaminations completely；Imbibition position magnet and fluid injection position magnet on guide groove ensure that magnetic bead cleaning area maximizes, and then guarantee cleaning effect.
Description
Technical field
The present invention relates to in-vitro diagnosis equipment, more particularly, to a kind of magnetic bead cleaning device suitable for in-vitro diagnosis equipment.
Background technique
Existing in-vitro diagnosis equipment (such as chemical illumination immunity analysis instrument, Biochemical Analyzer and nucleic acid instrument) utilizes chemistry more
Or instruction system of the bio-luminescence system as antigen-antibody reaction, so as to quantitative detection antigen or antibody.Isolating and purifying sample
The specific antibody or receptor (i.e. target body) in magnetic bead absorption sample are usually utilized when product, and waste liquid in reaction cup, note is then sucked out
Liquid cleaning, removes the not substance in conjunction with antigen or antibody and the other interfering substances being supported on magnetic bead in reaction solution.
It follows that magnetic bead cleaning is to influence the key factor of testing result.Existing magnetic bead cleaning device is by hair washing component and reaction
Cup rotary disk assembly composition draws the waste liquid or injection cleaning solution of reaction cup by hair washing component entirety ascending, descending.
Patent of invention CN103599898A discloses a kind of Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device, packet
The lifting punch block driven by spindle motor is included, lifting punch block submits wrong setting four and spits liquid needle and four aspirating needles, goes up and down punch block
Lower section be correspondingly arranged on the rotating disk of transmission mechanism driving, be provided with interior slide cartridge, interior slide cartridge on the mounting plate below rotating disk
Outer surface be provided with magnet, i.e. the magnet interior survey that is all mounted on reaction cup, effective cleaning area of magnetic bead is small, cleaning effect
Difference；Simultaneously because magnet is arranged at imbibition position, fluid injection position is not present magnet, can not achieve the pre-agglomeration of magnetic bead, lead to magnetic bead
It loses；Secondly, four are spat liquid needle and four aspirating needle cross arrangements, aspirating needle is a solely pipe, is drawn with aspirating needle highly concentrated
When spending full-bodied sample waste liquid, sample waste liquid is easy to be attached on aspirating needle needle wall, and aspirating needle outer wall washing difficulty is big, in turn
Lead to cross contamination occur between different samples, influence the accuracy of testing result, repeatability is poor.
Summary of the invention
It is an object of that present invention to provide a kind of magnetic bead cleaning devices suitable for in-vitro diagnosis equipment, can not only avoid intersecting
Pollution, moreover it is possible to guarantee magnetic bead cleaning effect, it is ensured that clean the interfering substance sticked on magnetic bead completely, moreover it is possible to magnetic bead be avoided to lose
It loses.
To achieve the above object, the present invention takes following technical proposals:
Magnetic bead cleaning device of the present invention suitable for in-vitro diagnosis equipment, the magnetic including being disposed on the substrate wash component,
Sliding is provided with the hair washing component of elevating mechanism driving on the riser of the substrate side, and the magnetic is washed on component and hair washing component
Under be correspondingly arranged；Open up jagged in the mounting base of the hair washing component, an edge of the notch is provided with self-cleaning
The liquid pumping needle of function is provided in mounting base along its circumferential uniform intervals from the liquid pumping needle and to be made of injection needle and aspirating needle
One note one inhales cleaning combination；It includes the rotating disk rotated by power source drive that the magnetic, which washes component, along its week in the rotating disk
Multiple rotating disks for containing the mounting hole of reaction cup, with multiple mounting hole corresponding positions are offered to uniform intervals
Lower section is provided with magnetic receiver, and the magnetic receiver includes connecting plate and is arranged in the outer peripheral guide groove of connecting plate, with the notch
It is provided with pre- adsorption potential magnet in the guiding groove sidewall of corresponding position, and is set in the guiding groove sidewall of the liquid pumping needle corresponding position
It is equipped with drawing liquid position magnet, is combined with the suction cleaning of a note one described in every group and is provided with magnet in the guiding groove sidewall of corresponding position
Group, the group of magnets include and the injection needle above and below corresponding fluid injection position magnet and with corresponding imbibition above and below the aspirating needle
Position magnet.
The mounting base of the hair washing component replaces with rectilinear structure, and the liquid pumping needle and a note one inhale cleaning combination
It is arranged along mounting base length direction interval；The rotating disk that the magnetic washes component replaces with the carrier of strip structure, described to lead
Strip structure is replaced with to slot correspondence.
The fluid injection position magnet of the group of magnets is arranged in pairs on the two sidewalls of the guide groove, the imbibition position magnetic of group of magnets
Iron is arranged in pairs on the two sidewalls of guide groove.
The fluid injection position magnet of the group of magnets is arranged on the inner sidewall of the guide groove, and the imbibition position magnet of group of magnets is set
It sets on the lateral wall of guide groove；Or the fluid injection position magnet of group of magnets is arranged on the lateral wall of the guide groove, group of magnets
Imbibition position magnet is arranged on the inner sidewall of guide groove.
The pre- adsorption potential magnet is arranged in pairs on the two sidewalls of the guide groove, and drawing liquid position magnet is arranged in pairs
On the two sidewalls of guide groove.
The pre- adsorption potential magnet is arranged on the inner sidewall of the guide groove, and drawing liquid position magnet is arranged in guide groove
Inner sidewall on；Or the pre- adsorption potential magnet and the ipsilateral arrangement of drawing liquid position magnet.
The liquid pumping needle is sleeve needle, including the T shape attachment base being made of fixing seat and cross bar, in the elongated slot of the cross bar
It is fitted with outwardly extending outer cleaning needle, the outer cleaning needle is interior to be connected with interior aspirating needle, the interior suction by fixation kit
The outer end of liquid needle extend outwardly out cleaning needle outer end formed inserting paragraph, the inner end of interior aspirating needle is successively pierced by outer cleaning needle outward
Construction section is formed with the fixing seat, is set with interior pipe joint on the construction section；Institute positioned at the interior aspirating needle side
The outer flushing channel for offering in fixing seat and being connected to the elongated slot is stated, is provided in fixing seat and is connected to the outer flushing channel
Outer pipe joint.
The fixation kit is the fixing groove being recessed by the outer cleaning needle needle wall or is by the interior aspirating needle needle
The fixing lug boss that wall evagination is formed, or the positioning column to be installed between interior aspirating needle and outer cleaning needle, or it is described to be sleeved on
Fixed ring on interior aspirating needle is arranged at intervals with fixed block in the fixed ring.
The liquid pumping needle is formula needle, and the formula needle includes the needle tubing being connected in the mounting base, is washed in the magnetic
The top of component is provided with by connector with service sink corresponding above and below the needle tubing, roof and bottom wall on the service sink
On offer a pair of of the perforation matched with needle tubing, be provided with water supply connector, the right side wall of service sink on the left side wall of service sink
On be provided with drainage joint.
The power source includes the motor for being erected at the base plate bottom, and the motor is sequentially connected with perpendicular by driving wheel
Straight shaft, the vertical shaft are rotatably arranged in the fixing sleeve on substrate, and the rotating disk is connected in vertical turn by bolt
The top of axis；The connecting plate is connected on the fixing sleeve.
The invention has the advantages that hair washing component on increase the liquid pumping needle with self-cleaning function, when magnetic is washed in first with pumping
The sample waste liquid for having neither part nor lot in reaction is sucked out liquid needle, carries out self-cleaning, cleaning effect to liquid pumping needle after sample waste liquid is sucked out completely
Fruit is good, avoids different sample cross contaminations completely；With fluid injection position magnet, and imbibition are set on the guide groove of injection needle corresponding position
Position magnet and fluid injection position magnet, which intersect, to stand facing each other or imbibition position magnet and fluid injection position magnet are all arranged in pairs, it is ensured that magnetic bead it is clear
Product of washing one's face maximizes, and then guarantees cleaning effect；Fluid injection position magnet has pre-agglomeration effect simultaneously, and magnetic bead amount lost is minimum
Change, reduces the probability of magnetic bead loss.
Detailed description of the invention
Fig. 1 is structural schematic diagram of the invention.
Fig. 2 is the structural schematic diagram of hair washing component of the present invention.
Fig. 3 is schematic cross-sectional view of the invention.
Fig. 4 is the layout drawing of group of magnets of the present invention.
Fig. 5 is the structural schematic diagram of sleeve needle of the present invention.
Fig. 6 is the schematic cross-sectional view of Fig. 5.
Fig. 7 .1 is another structural schematic diagram of fixation kit of the present invention.
Fig. 7 .2 is the third structural schematic diagram of fixation kit of the present invention.
Fig. 7 .3 be the present invention the fixation kit the 4th kind of structural schematic diagram.
Fig. 8 is another structural schematic diagram of the invention.
Fig. 9 is the structural schematic diagram of formula needle in Fig. 8.
Specific embodiment
As shown in Figure 1-3, the magnetic bead cleaning device of the present invention suitable for in-vitro diagnosis equipment, including be arranged in substrate
Magnetic on 1 washes component, and sliding is provided with the hair washing component of elevating mechanism driving, the magnetic on the riser 2 of 1 side of substrate
It washes component and hair washing component is correspondingly arranged up and down；It is described hair washing component mounting base 3.1 on open up it is jagged, the one of the notch
Edge is provided with the liquid pumping needle with self-cleaning function, is arranged from the liquid pumping needle along its circumferential uniform intervals in mounting base 3.1
Having five groups of notes one being made of injection needle 3.2 and aspirating needle 3.3 to inhale cleaning combination (certainly according to actual needs, can also set
It sets one group or two groups or three groups or four groups or more one note one of group and inhales cleaning combination)；It includes being driven by power source that the magnetic, which washes component,
The rotating disk 4.1 of dynamic rotation, the power source includes the motor 7.1 for being erected at 1 bottom of substrate, and the motor 7.1 passes through
Driving wheel is sequentially connected with vertical shaft 7.2, and the vertical shaft 7.2 is rotatably arranged in the fixing sleeve 7.3 on substrate 1, institute
State rotating disk 4.1 by bolt be connected in vertical shaft 7.2 top (certainly when practical manufacture, the mounting base 3.1 for component of washing hair
Rectilinear structure can be made, liquid pumping needle is located at the end of mounting base 3.1, and a note one inhales cleaning combination from liquid pumping needle along mounting base
3.1 length directions arrangement, the spacing between liquid pumping needle, injection needle and aspirating needle is the spacing between two adjacent reaction cups；It is right
Ying Di, the rotating disk that magnetic washes component, which is replaced with, moves along a straight line that track is mobile, carrying of structure in long strip by power source drive
Disk, uniform intervals open up multiple mounting holes for placing response cup along its length on carrier；Guide groove is strip
Structure, carrier drive reaction cup to move along a straight line along guide groove.)；
As shown in Figure 3,4, it is offered in the rotating disk 4.1 along its circumferential direction uniform intervals multiple for containing the installation of reaction cup
It is provided with magnetic receiver below hole 4.2, with the rotating disk 4.1 of multiple 4.2 corresponding positions of mounting hole, the magnetic receiver includes
In the outer peripheral guide groove 4.4 of connecting plate 4.3, connecting plate 4.3 is fixed on fixing sleeve 7.3 for connecting plate 4.3 and setting；With it is described
It is provided with pre- adsorption potential magnet 4.5 on 4.4 lateral wall of the guide groove of notch corresponding position, with leading for the liquid pumping needle corresponding position
When being provided with magnet 4.6(certain actual installation in drawing liquid position on 4.4 inner sidewall of slot, pre- adsorption potential magnet 4.5 and drawing liquid position magnet
4.6 are arranged on the inner sidewall of guide groove 4.4；Certainly, pre- adsorption potential magnet 4.5 can also be arranged in pairs at guide groove 4.4
Two sidewalls on, drawing liquid position magnet 4.6 is arranged in pairs on the two sidewalls of guide groove 4.4), pre- adsorption potential magnet 4.5 and drawing liquid
Spacing between the magnet 4.6 of position is consistent with the pitch of holes of two adjacent mounting holes 4.2, is located at pre- adsorption potential magnet 4.5 and the 5th group
Guide groove 4.4 between group of magnets is non-magnet area；
Magnetic is provided with as shown in figure 4, inhaling and being cleaned on 4.4 side wall of the guide groove for combining corresponding position with a note one described in every group
Iron group, guide groove 4.4 corresponding with about 3.2 injection needle is fluid injection position, with corresponding guide groove above and below the aspirating needle
For imbibition position, group of magnets includes the fluid injection position magnet 4.7 that fluid injection position is arranged in and the imbibition position magnet 4.8 that imbibition position is arranged in,
First group of group of magnets, third group group of magnets and the 4th group of group of magnets are all made of following arrangement: the setting of fluid injection position magnet 4.7 exists
On the inner sidewall of the guide groove 4.4, the imbibition position magnet 4.8 of group of magnets is arranged on the lateral wall of guide groove 4.4；Such as Fig. 4
Shown, second group of group of magnets and the 4th group of group of magnets are all made of following arrangement: the setting of fluid injection position magnet 4.7 of group of magnets exists
On the lateral wall of the guide groove 4.4, (certain root is arranged on the inner sidewall of guide groove 4.4 in the imbibition position magnet 4.8 of group of magnets
Factually demand, group of magnets can also following arrangement, the fluid injection position magnet 4.7 of group of magnets is arranged in pairs at the guide groove
On 4.4 two sidewalls, the imbibition position magnet 4.8 of group of magnets is arranged in pairs on the two sidewalls of guide groove 4.4), clean magnetic bead
Area maximizes, it is ensured that washes the interfering substance on magnetic bead completely, cleaning effect is good；Fluid injection position magnet 4.7 can guarantee
Cohesion is realized before magnetic bead imbibition, and magnetic bead is avoided to lose.
As shown in Figure 5,6, the liquid pumping needle is sleeve needle, including the T shape attachment base 5.1 being made of fixing seat and cross bar,
It is fitted with outwardly extending outer cleaning needle 5.3 in the elongated slot 5.2 of the cross bar, passes through fixed group in the outer cleaning needle 5.3
Part is connected with interior aspirating needle 5.4, and the outer end of the interior aspirating needle 5.4 5.3 outer end of cleaning needle out that extends outwardly forms inserting paragraph,
The inner end of interior aspirating needle 5.4 is successively pierced by outer cleaning needle 5.3 outward and the fixing seat forms construction section, covers on the construction section
Equipped with interior pipe joint 5.5；It offers in the fixing seat of interior 5.4 side of aspirating needle and connects with the elongated slot 5.2
Logical outer flushing channel 5.6 is provided with the outer pipe joint 5.7 being connected to the outer flushing channel 5.6 in fixing seat.
As shown in figure 5, the fixation kit is two fixing grooves 5.8 being recessed by the outer 5.3 needle wall of cleaning needle；
Certainly, fixation kit can also be two fixing lug boss 5.9 formed by the interior 5.4 needle wall evagination of aspirating needle, specific as schemed
7.1 shown；It can also be two positioning columns 5.10 being installed between interior aspirating needle 5.4 and outer cleaning needle 5.3, it is specific as schemed
7.2 shown；It can also be the fixed ring 5.11 being sleeved on the interior aspirating needle 5.4, be spaced setting in the fixed ring 5.11
There is fixed block 5.12, specifically as shown in Fig. 7 .3；
When sample drawn waste liquid, hair washing component drives sleeve needle decline, so that in the inserting paragraph intercalation reaction cup of interior aspirating needle 5.4
Sample waste liquid in, outer 5.3 bottom of cleaning needle is located above sample waste liquid, and sample is sucked out to specified returnable drainage system
Interior, then rotating disk drives reaction cup to turn an angle, so that liquid pumping needle, in the gap between two mounting holes, cleaning is
Inwardly aspirating needle 5.4 and the interior injection cleaning solution of outer cleaning needle 5.3, interior 5.4 length of aspirating needle are longer than outer cleaning needle to system simultaneously
5.3, the cleaning solution in outer cleaning needle 5.3 washes away interior aspirating needle 5.4 by its outlet outflow, guarantee in 5.4 outer wall of aspirating needle it is clear
Effect is washed, the cleaning needle in interior aspirating needle 5.4 is clean by interior 5.4 inner wall washing of aspirating needle during flowing downward, and cleans waste liquid
It flows directly into guide groove 4.4, cleaning effect is good, avoids different samples cross contamination occur completely, improves testing result
Accuracy.
When certain actual installation, liquid pumping needle can also use formula needle as shown in Figure 8,9, and the formula needle includes being connected
Needle tubing 6.1 in the mounting base 3.1 is provided with and the needle tubing in the top that the magnetic washes component by connector 6.2
About 6.1 corresponding service sinks 6.3 offer one matched with needle tubing 6.1 on the roof and bottom wall on the service sink 6.3
To perforation, it is provided with water supply connector 6.4 on the left side wall of service sink 6.3, is provided with drainage joint on the right side wall of service sink 6.3
6.5.When extracting discarded sample, formula needle drops to preset height with hair washing component, and the needle tubing 6.1 of formula needle passes through service sink
In sample waste liquid in 6.3 intercalation reaction cups, sample waste liquid is sucked out to specified returnable for drainage system work, rotating disk
Reaction cup is driven to turn an angle, so that formula needle, in the gap between two mounting holes, cleaning system is simultaneously to cleaning
Cleaning solution is constantly injected in pond 6.3 and needle tubing 6.1, the cleaning solution in formula needle uphill process in service sink 6.3 cleans needle tubing 6.1
Outer wall, cleaning system stops working after rising to predeterminated position, cleans waste liquid in the process of cleaning and flows into guide groove 4.4,
Formula needle cleaning effect is good, can be avoided sample wall built-up, and then avoid cross contamination.
When work, power source drive rotating disk 4.1 is rotated, and reaction cup is rotated along guide groove 4.4, and is rotated by non-magnet area
To the corresponding pre- adsorption potential of pre- adsorption potential magnet 4.5, after the static preset time of pre- adsorption potential, magnetic bead is attached to close reaction cup
The reaction cup inner face of 4.4 lateral wall of guide groove realizes the pre- absorption of magnetic bead；Rotating disk 4.1 drives reaction cup to turn to drawing liquid position,
Magnetic bead is transferred to the reaction cup surface on 4.4 inner sidewall of guide groove under the action of magnet 4.6 of drawing liquid position, washes hair under component
It is down to designated position, in the sample waste liquid in the interior cleaning needle intercalation reaction cup of sleeve needle, sample waste liquid is pumped to specifying back
In receptacle, then rotating disk 4.1 turns an angle, and then cleaning system cleans sleeve needle, and sleeve needle has been cleaned
Cheng Hou, rotating disk 4.1 drive reaction cup to be moved to 4.7 corresponding position of fluid injection position magnet of first group of group of magnets, pass through fluid injection
Needle 3.2 injects cleaning solution into reaction cup, and the drive of rotating disk 4.1 reaction cup is moved to the imbibition position magnet of first group of group of magnets
4.8 corresponding positions, after the static preset time of reaction cup, magnetic bead is adsorbed on the reaction cup close to 4.4 lateral wall of guide groove again
On inner face, primary note-suction operation of magnetic bead in reaction cup is realized；Such repetitive cycling five times, realize five notes-suction behaviour of magnetic bead
Make, cleaning effect is good.Certainly, according to actual needs, can also after sample drawn waste liquid, to magnetic bead carry out once or twice or
Three times or four notes-suction operates.
Claims (10)
1. a kind of magnetic bead cleaning device suitable for in-vitro diagnosis equipment, the magnetic including being arranged on substrate (1) washes component, described
Sliding is provided with the hair washing component of elevating mechanism driving on the riser (2) of substrate (1) side, and the magnetic washes component and hair washing component
It is correspondingly arranged up and down；It is characterized by: opening up jagged, one side of the notch in the mounting base (3.1) of the hair washing component
Edge is provided with the liquid pumping needle with self-cleaning function, is arranged from the liquid pumping needle along its circumferential uniform intervals in mounting base (3.1)
There is the note one being made of injection needle (3.2) and aspirating needle (3.3) to inhale cleaning combination；It includes being driven by power source that the magnetic, which washes component,
The rotating disk (4.1) of rotation is moved, is offered on the rotating disk (4.1) along its circumferential uniform intervals multiple for containing reaction cup
Mounting hole (4.2), and be provided with magnetic receiver below the rotating disks (4.1) of multiple mounting hole (4.2) corresponding positions, institute
Stating magnetic receiver includes connecting plate (4.3) and setting in connecting plate (4.3) outer peripheral guide groove (4.4), corresponding with the notch
Pre- adsorption potential magnet (4.5), the guide groove with the liquid pumping needle corresponding position are provided on the guide groove (4.4) side wall at place
(4.4) it is provided with drawing liquid position magnet (4.6) on side wall, inhales the guide groove that corresponding position is combined in cleaning with a note one described in every group
(4.4) group of magnets is provided on side wall, the group of magnets includes and corresponding fluid injection position magnet above and below the injection needle (3.2)
(4.7) and with the aspirating needle (3.3) up and down corresponding imbibition position magnet (4.8).
2. being suitable for the magnetic bead cleaning device of in-vitro diagnosis equipment according to claim 1, it is characterised in that: the hair washing component
Mounting base (3.1) replace with rectilinear structure, the liquid pumping needle and a note one inhale cleaning combination along mounting base length side
It is arranged to interval；The rotating disk (4.1) that the magnetic washes component replaces with the carrier of strip structure, the guide groove (4.4)
Correspondence replaces with strip structure.
3. the magnetic bead cleaning device according to claim 1 or claim 2 suitable for in-vitro diagnosis equipment, it is characterised in that: the magnet
The fluid injection position magnet (4.7) of group is arranged in pairs on the two sidewalls of the guide groove (4.4), the imbibition position magnet of group of magnets
(4.8) it is arranged in pairs on the two sidewalls of guide groove (4.4).
4. the magnetic bead cleaning device according to claim 1 or claim 2 suitable for in-vitro diagnosis equipment, it is characterised in that: the magnet
The fluid injection position magnet (4.7) of group is arranged on the inner sidewall of the guide groove (4.4), and the imbibition position magnet (4.8) of group of magnets is set
It sets on the lateral wall of guide groove (4.4)；Or fluid injection position magnet (4.7) setting of group of magnets is in the outer of the guide groove (4.4)
On side wall, the imbibition position magnet (4.8) of group of magnets is arranged on the inner sidewall of guide groove (4.4).
5. the magnetic bead cleaning device according to claim 1 or claim 2 suitable for in-vitro diagnosis equipment, it is characterised in that: the pre-suction
Attached position magnet (4.5) is arranged in pairs on the two sidewalls of the guide groove (4.4), and drawing liquid position magnet (4.6) is arranged in pairs
On the two sidewalls of guide groove (4.4).
6. the magnetic bead cleaning device according to claim 1 or claim 2 suitable for in-vitro diagnosis equipment, it is characterised in that: the pre-suction
Attached position magnet (4.5) is arranged on the inner sidewall of the guide groove (4.4), and drawing liquid position magnet (4.6) is arranged in guide groove
(4.4) on inner sidewall；Or the pre- adsorption potential magnet (4.5) and the drawing liquid position magnet (4.6) ipsilateral arrangement.
7. the magnetic bead cleaning device according to claim 1 or claim 2 suitable for in-vitro diagnosis equipment, it is characterised in that: the drawing liquid
Needle is sleeve needle, including the T shape attachment base (5.1) being made of fixing seat and cross bar, is fitted in the elongated slot (5.2) of the cross bar
Outwardly extending outer cleaning needle (5.3), the outer cleaning needle (5.3) is interior to be connected with interior aspirating needle (5.4) by fixation kit,
The outer end of the interior aspirating needle (5.4) extend outwardly out cleaning needle (5.3) outer end formed inserting paragraph, interior aspirating needle (5.4)
Inner end is successively pierced by outer cleaning needle (5.3) outward and the fixing seat forms construction section, is set with interior pipeline on the construction section
Connector (5.5)；It offers in the fixing seat of interior aspirating needle (5.4) side and to be connected to the elongated slot (5.2)
Outer flushing channel (5.6) is provided with the outer pipe joint (5.7) being connected to the outer flushing channel (5.6) in fixing seat.
8. being suitable for the magnetic bead cleaning device of in-vitro diagnosis equipment according to claim 7, it is characterised in that: the fixation kit
For the fixing groove (5.8) being recessed by outer cleaning needle (5.3) the needle wall, or for outside by interior aspirating needle (5.4) the needle wall
The fixing lug boss (5.9) convexed into, or to be installed on the positioning column between interior aspirating needle (5.4) and outer cleaning needle (5.3)
(5.10), or it is the fixed ring (5.11) being sleeved on the interior aspirating needle (5.4), is spaced setting on the fixed ring (5.11)
There are fixed block (5.12).
9. the magnetic bead cleaning device according to claim 1 or claim 2 suitable for in-vitro diagnosis equipment, it is characterised in that: the drawing liquid
Needle is formula needle, and the formula needle includes the needle tubing (6.1) being connected on the mounting base (3.1), washes component in the magnetic
Top is provided with and corresponding service sink (6.3) above and below the needle tubing (6.1), the service sink (6.3) by connector (6.2)
On roof and bottom wall on offer a pair of of the perforation matched with needle tubing (6.1), be provided on the left side wall of service sink (6.3)
Water supply connector (6.4) is provided with drainage joint (6.5) on the right side wall of service sink (6.3).
10. being suitable for the magnetic bead cleaning device of in-vitro diagnosis equipment according to claim 1, it is characterised in that: the power source
Motor (7.1) including being erected at the substrate (1) bottom, the motor (7.1) are sequentially connected with vertical turn by driving wheel
Axis (7.2), the vertical shaft (7.2) are rotatably arranged on the fixing sleeve (7.3) on substrate (1) Nei, and the rotating disk (4.1) is logical
Cross the top that bolt is connected in vertical shaft (7.2)；The connecting plate (4.3) is connected on the fixing sleeve (7.3).
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| CN110586557A (en) * | 2019-09-11 | 2019-12-20 | 苏州长光华医生物医学工程有限公司 | Cleaning and separating device |
| CN111136584A (en) * | 2019-12-30 | 2020-05-12 | 天长市华磁磁电有限公司 | Dust removing equipment for ferrite soft magnetic core |
| CN112858660A (en) * | 2019-11-28 | 2021-05-28 | 深圳市帝迈生物技术有限公司 | Magnetic separation cleaning system and imbibition needle subassembly, immunoassay appearance thereof |
| CN112881367A (en) * | 2019-11-29 | 2021-06-01 | 深圳市新产业生物医学工程股份有限公司 | Cleaning module, sample analyzer with same and cleaning method |
| CN114643128A (en) * | 2022-03-25 | 2022-06-21 | 北京唯公医疗技术有限公司 | Test tube magnetic separation and belt cleaning device |
| CN115156215A (en) * | 2022-08-02 | 2022-10-11 | 宋世琦 | Magnetic particle cleaning device and cleaning method for immunoassay device |
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| CN114643128A (en) * | 2022-03-25 | 2022-06-21 | 北京唯公医疗技术有限公司 | Test tube magnetic separation and belt cleaning device |
| CN115156215A (en) * | 2022-08-02 | 2022-10-11 | 宋世琦 | Magnetic particle cleaning device and cleaning method for immunoassay device |
| CN115932310A (en) * | 2022-12-27 | 2023-04-07 | 山东中鸿特检生物科技有限公司 | Detachable sample site and chemiluminescence immunoassay device |
| CN115932310B (en) * | 2022-12-27 | 2023-08-18 | 山东中鸿特检生物科技有限公司 | Detachable sample position and chemiluminescent immunoassay device |
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Address after: 450016 No.199, Jingkai 15th Street, Zhengzhou Economic and Technological Development Zone, Henan Province Patentee after: AUTOBIO LABTEC INSTRUMENTS Co.,Ltd. Country or region after: China Address before: No. 199, 15th Street, economic and Technological Development Zone, Zhengzhou City, Henan Province Patentee before: AUTOBIO LABTEC INSTRUMENTS Co.,Ltd. Country or region before: China |