CN109744534A - Dedicated clinical nutrition formula of Parkinsonian and preparation method thereof - Google Patents
Dedicated clinical nutrition formula of Parkinsonian and preparation method thereof Download PDFInfo
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- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims abstract description 32
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Abstract
The invention discloses a kind of Parkinson's disease tailored version clinical nutrition formulas and preparation method thereof, it is as follows according to poidometer ingredient: soybean germ powder 18-36%, alfalfa seedling powder 15-30%, the ripe powder 16-24% of semen sojae atricolor, Flemingia philippinensis extract 6-14%, vitamin D 0.02-0.1%, lecithin 0.5-1%, white granulated sugar 3-6%, vitamin C 0.03-0.08%.The dedicated clinical nutrition formula of Parkinsonian of the invention; it is preferred that rich in isoflavone like substance; dopamine secretion can be excited; and molecular mechanisms of action clearly natural vegetable powder as primary raw material; auxiliary can protect dopamine neuron and be conducive to the substance of nerve signal transmitting as auxiliary material; the quantity and frequency for the treatment of medication can be not only effectively reduced, improves Parkinsonian's symptom, clinical side effects caused by drug improper use can more be effectively relieved.
Description
Technical field
The present invention relates to nutrient formulation field more particularly to a kind of Parkinson's disease tailored version clinical nutrition formula and its preparations
Method.
Background technique
Parkinson's disease (Parkinson ' s disease, PD) is common old nervous system degenerative disease, clinical table
It is now mainly static tremor, splinting, bradykinesia, posture and abnormal gait.In China, over-65s crowd's Parkinson's disease
Illness rate be about 1.7%, and with the aggravation of aging of population, the quantity of the following Parkinsonian is also possible to continue
Increase.Research thinks that the most important pathological change of Parkinson's disease is Parkinsonian's substantia nigra of midbrain dopaminergic nerve at present
The denaturation of member is dead, and Striatal Dopamine Content conspicuousness is caused to reduce and cause a disease therefrom.The pathogenic factor ratio of Parkinson's disease
More complex, inherent cause, environmental factor, age ageing, oxidative stress etc. can influence the secretion of dopamine.Therefore, pa is adjusted
The secretion of the gloomy patient's brain dopamine of gold can play good therapeutic effect.But since Parkinsonian needs all the life
Medication, therapeutic agent almost can cause diversified side effect, such as: depression and anxiety, tetchiness, illusion, illusion, essence
Refreshing disorder, consciousness are in a trance etc., and become more complicated the treatment of disease.Therefore, exploitation is using natural plants as primary raw material
Parkinsonian's professional clinical nutrient formulation, the appropriate quantity and frequency for reducing treatment medication, can not only improve Parkinson's disease
Patient's holistic health is more of great significance to clinical side effects caused by alleviating drug improper use.
Studies have shown that isoflavones and its derivative can effectively adjust the secretion of internal dopamine.Our research is further
It was found that isoflavones and its derivative can be by adjusting the expression of clock gene Period1 in hypothalamus, to adjust more
The secretion of bar amine.And in natural plants, the total isoflavone substance that leguminous plant contains is higher, especially with soya bean and alfalfa
Content highest.Soya bean is the widely used glyceride stock of the mankind, and unsaturated fatty acid and isoflavone content are high, can effectively be prevented
The only absorption and improvement female incretion function of cholesterol.Alfalfa contains 5 kinds of vitamins, 10 kinds of minerals and flavonoids
The sour 3 kinds of distinctive nutrients of plant of element, carotenoid, phenolic, there is anti-oxidant, anti-blood clotting, anti-cholesterol to absorb, is pre-
The functions such as anti-optic nerve degeneration.Its isoflavone content of semen sojae atricolor is also higher, belongs to pulse family with soya bean, and its protein content is about
36%-40%, higher than the protein content in soya bean, meat, egg and milk.In addition, there are also stronger anti-oxidant for Testa sojae atricolor
Ability, and can " hepcidin " intracorporal by people improve absorption of the body to ferro element, so as to improve Anemia.Tendril
Philippine flemingia root, alias colour of loess chicken, golden pheasant land (" Illustrated Book on Plants "), rat tail, saturating pheretima, beautiful millettia root, winged steed, Niu Duntou
Deng, it is very heavy to uproot for medicinal, have dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, strengthen muscles and bones, anti-inflammatory analgetic the effects of.Our research hair
Existing, a large amount of isoflavone like substance and its derivative are also contained in philippine flemingia root root, Auriculasin tool especially wherein included
There is stronger adjusting dopamine secretion.Vitamin D is a kind of steroid hormone, mainly by 7-DHC in skin
Interior irradiate through daylight Type B ultraviolet light changes, remaining derives from food intake on a small quantity.Vitamin D deficiency is in nervous system disease
Disease such as cerebral arterial thrombosis, Alzheimer's disease, vascular dementia, multiple sclerosis, Parkinson's disease occurrence and development in
Multiple links play a significant role.Research also indicates that vitamin D receptor (VDR) Fokl gene loci CC genotype and Parkinson's disease
There are correlation, vitamin D can increase black substance and corpus straitum generates the speed of neurotrophic factor GDNF, protection dopaminergic mind
It is damaged through member from cytotoxic substance.Lecithin, also known as lecithin are known as the " third arranged side by side with protein, vitamin
Nutrient ".The exogenous choline 90% of needed by human body is provided by lecithin, and the content of lecithin accounts for about it in cranial nerve cell
The 17%-20% of quality." choline " is the basis of soybean lecithin, and the ample supply of lecithin can guarantee " choline " and people
Intracorporal " acetyl " synthesizes " acetylcholine ", and " acetylcholine " is a kind of Information Conduction substance of big intracerebral, to improve brain
The activation degree of cell improves memory and intellectual level.In addition, lecithin also enhances the feature of instant food dispersibility,
The colloidal stability after nutrient formulation reconstitutes can be enhanced.
The dedicated clinical nutrition formula of Parkinsonian of the present invention.Compared with the full nutrition emphasized of related patents
Conditioning (patent of such as number of patent application 201810445031.6 is emphasized to utilize full nutrition recuperating patients with cerebral apoplexy) either foundation
Theory of traditional Chinese medical science (emphasize to utilize " middle residence that disappears is mended ", in the tradition of " balanced tone " by the patent of number of patent application 201710796790.2
Medical knowledge view reason is twitched and hyperactivity) nutrient formulation compare, the theory of constitution of our nutrient formulation is according to Parkinson's sufferer
The insufficient clinical pathologic characteristic of person's dopamine secretion, stronger tune of sorting are selected rich in isoflavone like substance, and DOPA can be excited
Amine secretion, and molecular mechanisms of action clearly natural materials, as soybean germ, alfalfa, semen sojae atricolor, Flemingia philippinensis all contain
There is a large amount of isoflavones and its derivative for adjusting dopamine secretion, vitamin D has the function of protecting dopamine neuron, and
Lecithin has the function of supplementing neurotransmitter auxiliary Parkinson's disease conditioning.In addition, this patent additionally provide it is a variety of rich in different Huang
Proportion and detailed nutrient formulation preparation method of the raw-food material of ketone in nutrient formulation.
Summary of the invention
The present invention provides the dedicated clinical nutrition formulas of Parkinsonian.
The present invention also provides the preparation methods of the dedicated clinical nutrition formula of Parkinsonian.
The raw material that the present invention includes has: soybean germ powder, alfalfa seedling powder, the ripe powder of semen sojae atricolor, Flemingia philippinensis extract,
Vitamin D, lecithin, white granulated sugar and vitamin C.
Crucifer beverage of the invention, it is as follows according to poidometer ingredient: soybean germ powder 18-36%, pale reddish brown lucerne
Mu seedling powder 15-30%, the ripe powder 16-24% of semen sojae atricolor, Flemingia philippinensis extract 6-14%, vitamin D 0.02-0.1%, lecithin
Rouge 0.5-1%, white granulated sugar 3-6%, vitamin C 0.03-0.08%.
The dedicated clinical nutrition formula preparation method of Parkinsonian of the present invention is as follows
(1) soybean germ powder and alfalfa seedling powder are to select fresh soyabean plumule and alfalfa seedling, dry by freezing
It is broken after dry to obtain soybean germ powder and alfalfa seedling powder；The ripe powder of semen sojae atricolor is semen sojae atricolor after material frying machine fries, and smashes it through 80-
120 mesh sieve obtain；Flemingia philippinensis extract is will to extract after very heavy crushing of uprooting through ethyl alcohol, then obtain alcohol-soluble through elution
Extract after concentration, obtains extract powder by spray drying under the conditions of outlet temperature is 130 DEG C, and this method is more advantageous
The concentration and extraction of isoflavone like substance in Flemingia philippinensis；
It (2) will be by (1) acquisition soybean germ powder, alfalfa seedling powder, the ripe powder of semen sojae atricolor and Flemingia philippinensis extract, together
Vitamin D, lecithin, white granulated sugar and vitamin C uniformly mix, and mixed proportion is soybean germ powder 18-36%, alfalfa seedling
Powder 15-30%, the ripe powder 16-24% of semen sojae atricolor, Flemingia philippinensis extract 6-14%, vitamin D 0.02-0.1%, lecithin
0.5-1%, white granulated sugar 3-6%, vitamin C 0.03-0.08%.After the infrared sterilizing of said mixture, it is packaged into bag.
Isoflavone-containing substance about 350- in the dedicated clinical nutrition formula powder of Parkinsonian of such method preparation
750mg/Kg.In addition, this dedicated clinical nutrition formula powder of Parkinsonian can also be in above-mentioned Four Plants powder and extract
In, other edible plants raw materials containing isoflavones are added, but formula powder need to meet concerned countries food and medicine in principle
Standard and regulation.
The present invention has the advantage that the dedicated clinical nutrition formula of Parkinsonian of the invention, preferably rich in different
Flavonoid substances, can excite dopamine secretion and molecular mechanisms of action clearly natural vegetable powder as primary raw material,
Auxiliary can protect dopamine neuron and be conducive to nerve signal transmitting substance as auxiliary material, Parkinson's disease can be efficiently modified
The insufficient clinical pathologic characteristic of patient's dopamine secretion.
Specific embodiment
The following examples will make the present invention more specifically to explain, but the present invention is not limited only to these implementations
Example, these same embodiments are not also limit the invention in any way.
Embodiment 1:
(1) the dedicated clinical nutrition formula composition of Parkinsonian of the invention includes: soybean germ powder 18-36%, purple
Russian fenugreek herb seedling powder 15-30%, the ripe powder 16-24% of semen sojae atricolor, Flemingia philippinensis extract 6-14%, vitamin D 0.02-0.1%,
Lecithin 0.5-1%, white granulated sugar 3-6%, vitamin C 0.03-0.08%.
Embodiment 2:
(1) the dedicated clinical nutrition formula composition of Parkinsonian of the invention includes: soybean germ powder 20-40%, purple
Russian fenugreek herb seedling powder 15-30%, the ripe powder 16-24% of black rice, Flemingia philippinensis extract 6-14%, vitamin D 0.02-0.1%,
Lecithin 0.5-1%, white granulated sugar 3-6%, vitamin C 0.03-0.08%.
Embodiment 3:
(1) the dedicated clinical nutrition formula composition of Parkinsonian of the invention includes: soybean germ powder 18-36%, purple
Russian fenugreek herb seedling powder 15-30%, ripe Semen Lablab Album powder 6-24%, Flemingia philippinensis extract 6-14%, vitamin D 0.02-0.1%,
Lecithin 0.5-1%, white granulated sugar 3-6%, vitamin C 0.03-0.08%.
Embodiment 4:
(1) the dedicated clinical nutrition formula composition of Parkinsonian of the invention includes: soybean germ powder 20-35%, purple
Russian fenugreek herb seedling powder 6-14%, the ripe powder 16-24% of semen sojae atricolor, black rice ripe powder 16-24%, Flemingia philippinensis extract 6-14%, dimension life
Plain D 0.02-0.1%, lecithin 0.5-1%, white granulated sugar 3-6%, vitamin C 0.03-0.08%.
Embodiment 5:
(1) the dedicated clinical nutrition formula composition of Parkinsonian of the invention includes: soybean germ powder 18-36%, purple
Russian fenugreek herb seedling powder 6-24%, semen sojae atricolor ripe powder 6-24%, ripe Semen Lablab Album powder 6-24%, Flemingia philippinensis extract 6-14%, dimension life
Plain D 0.02-0.1%, lecithin 0.5-1%, white granulated sugar 3-6%, vitamin C 0.03-0.08%.
Embodiment 6:
(1) the dedicated clinical nutrition formula composition of Parkinsonian of the invention includes: soybean germ powder 18-36%, purple
Russian fenugreek herb seedling powder 6-14%, the ripe powder 6-14% of semen sojae atricolor, black rice ripe powder 16-24%, ripe Semen Lablab Album powder 6-24%, Flemingia philippinensis mention
Take object 6-14%, vitamin D 0.02-0.1%, lecithin 0.5-1%, white granulated sugar 3-6%, vitamin C 0.03-0.08%.
Claims (4)
1. Parkinson's disease tailored version clinical nutrition formula, which is characterized in that as follows according to poidometer ingredient: soybean germ powder 18-
36%, alfalfa seedling powder 15-30%, the ripe powder 16-24% of semen sojae atricolor, Flemingia philippinensis extract 6-14%, vitamin D 0.02-
0.1%, lecithin 0.5-1%, white granulated sugar 3-6%, vitamin C 0.03-0.08%.
2. according to claim 1, Parkinson's disease tailored version clinical nutrition formula, it is characterised in that: preferred rich in different
Flavonoid substances, can excite dopamine secretion and molecular mechanisms of action clearly natural vegetable powder as primary raw material,
Auxiliary can protect dopamine neuron and be conducive to nerve signal transmitting substance as auxiliary material, Parkinson's disease can be efficiently modified
The insufficient clinical pathologic characteristic of patient's dopamine secretion.
3. according to claim 1 described in -2, Parkinson's disease tailored version clinical nutrition formula, core group is divided into: soybean germ powder,
Alfalfa seedling powder, the ripe powder of semen sojae atricolor, Flemingia philippinensis extract, vitamin D and lecithin.In addition, this Parkinson's disease is dedicated
Type clinical nutrition formula is not limited to above-mentioned plant material, the increase and decrease of type can according to isoflavone content number and relevant food
Depending on the specific requirement of drug act.
4. Parkinson's disease tailored version clinical nutrition formula according to claim 1 to 3, it is characterised in that:
(1) soybean germ powder and alfalfa seedling powder are to select fresh soyabean plumule and alfalfa seedling, after freeze-drying,
It is broken, soybean germ powder and alfalfa seedling powder are obtained after crossing 80 mesh sieve；
(2) the ripe powder of semen sojae atricolor is semen sojae atricolor after material frying machine fries, and smashes it through the acquisition of 80-120 mesh sieve；
(3) Flemingia philippinensis extract is to extract after very heavy crushing of uprooting through ethyl alcohol, then obtain alcohol-soluble after eluting and extract
Object, and after concentration, extract powder is obtained by spray drying under the conditions of outlet temperature is 130 DEG C, this method is more advantageous to
The concentration and extraction of isoflavone like substance in Flemingia philippinensis raw material；
(4) vitamin D and lecithin are food-grade, and lecithin generally selects soybean lecithin.
(5) raw material described in (1)~(4) is uniformly mixed with white granulated sugar and vitamin C, after infrared sterilizing, is packaged into bag,
In case reconstituting.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111296601A (en) * | 2020-03-12 | 2020-06-19 | 青海大学 | Levodopa-rich broad bean sprout vegetable tea bag and making method thereof |
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