CN102308989B - Health care composition of formica rufa, grape and propolis extracts - Google Patents
Health care composition of formica rufa, grape and propolis extracts Download PDFInfo
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Abstract
The invention discloses a health care composition of formica rufa, grape and propolis extracts. The composition contains a formica rufa extract, grape polyphenol and an propolis extract. The invention enables shortcomings of a single sided curative effect and poor action resulting from individual utilization of the formica rufa extract, grape polyphenol or the propolis extract to be overcome, and health care and treatment effects to be optimized.
Description
Technical field the present invention relates to field of health care products, more particularly, the present invention relates to the composition of a kind of Formica rufa with health care, grape, propolis extract, and the purposes of said composition in preparation food and health products.
Background technology
(1) health ministry formally is decided to be the health products new resources with red ant
Just begin one's study as far back as the beginning of this century pharmacological action of red ant of American scientist.Through in earnest analysis and research, they make injection to the body fluid that extracts in the ant body, be expelled to 200 ostalgia patients, the result, and all patients' symptom all obviously alleviates.
China classifies ant as medicine and the existing history in 3000 of health food." Zhou Li " " Book of Rites " " elegant ", Shennong's Herbal are until bright Li Shizhen (1518-1593 A.D.) Compendium of Material Medica all has pair ant and ant ovum as the discussion of medicine and food.In recent years advocate the exploitation insect food abroad, ant is one of important kind wherein.Traditional Chinese medicine thinks, red ant is warm in nature, flavor is sweet, have strengthen the body resistance to consolidate the constitution, tonifying kidney and strengthening yang, the flourish muscle that nourishes blood, the effect of the vein relaxing that eliminates the phlegm, and the record that has many treatment diseases and health to lengthen the life.
For the first time ant is used as medicine in the supplement to the Herbal of the Tang Dynasty Chen Cangqi.Arrived the Ming Dynasty, Yongle period has the villager that red ant is pulverized to mix Chinese herbal medicine and make " the strong strong longevity ball of power ", live at the age of one hundred years old.There is an old man often to eat red ant in Jilin and lives by 140 years old, also can do farm work with descending.
Claim that at Compendium of Material Medica the 40 volume " worm section ant " Li Shizhen (1518-1593 A.D.) ant is " profound coltfoal ", and carry: " the ant oviparity of living in caves; its residence has etc.; its row has team can know that rain waits, and the spring goes out the winter and bites; its ovum name, recluse dig it; have to bucket stone person, and ancients eat it, so the beans of " then interior ", " all officials " feedback food have fish or meat paste also.Ordinary person eats it, beneficial gas pool face, the person's of dying food and heal also.
Liu Xun " mountain range table record is different " says: hand over the chief of a tribe between the cave of Guangxi, get the ant ovum more, washing in a pan only is sauce, says flavor like meat pulp, and non-honorable non-availability also.Add: the many ants in the south of the Five Ridges, its nest such as thin wadding capsule.Connect branch band leaf, that person stores it with cloth bag, is sold to support the mandarin orange person, to ward off worm ...This shows that ancients have grasped the nutritive value of red ant and the medical value of ant poison already.Traditional Chinese medicine is thought, red ant is a kind of tonic medicine of gentleness, have and strengthen the body resistance to consolidate the constitution, tonifying kidney and strengthening yang, flourish muscle nourishes blood, the effect of dispelling wind and removing obstruction in the meridians, wherein the most remarkable with kidney tonifying, be used for control aging, rheumatoid arthritis, rheumatic arthritis, the diseases such as alopecia, impotence, neurasthenia there is preferably result for the treatment of.In addition, red ant goods can become female hormone in the internal conversion of women's body, raise libido, and increase secretion, the effects such as expansion breast lactagogue.
The human record that edible red ant is just arranged a long time ago just records in ancient books in the pre-Qin days " all gift heavenly officials fish or meat paste people ", " in the Book of Rites then " that people gather ant and the ant ovum is edible for emperor and noble, is referred to as " fish or meat paste " (ant egg sauce).
Some local people of northeast and the Inner Mongol, red ant commonly used is stewed bean curd, or makes together a ball with red ant grinds with minced meat, and is edible for the puerpera, to reach the effect of lactagogue.
The modern science analytical proof, the micro-element nutrition of Changbai Mountain wild red ant is worth high.And compare with other regional red ants, original low temperature tolerance is arranged.Smart through the Formica rufa that science is extracted, composition is purer, and nutrition content is more concentrated, more remarkable effect:
1, Formica rufa protamine matter content accounts for 42%-67%;
2, the Formica rufa essence contains 26 seed amino acids such as threonine, lysine, wherein contains necessary 8 seed amino acids of human body (threonine, phenylalanine, valine, leucine, isoleucine, lysine, methionine, tryptophan);
3, the Formica rufa essence contains 28 kinds of trace elements.Such as tin, zinc, calcium, manganese, iron, cobalt, copper, iodine, molybdenum, chromium, nickel, selenium, silicon, fluorine, vanadium etc.Micronutrient levels is 4 times of egg, 6 times of milk.The red ant of per kilogram contains about zinc 180mg, and is higher 8 times than soybean, can be rated as various animals and plants zinc contents.
4, the Formica rufa essence contains high energy phosphate compound (ATP) and contains formic acid, cursive script formaldehyde (HCHO) chest formaldehyde (G11H14O), the special compounds such as citral (C10H16O);
5, the Formica rufa essence contains multivitamin (B1, B2, B12, VE) etc.;
6, the Formica rufa essence also contains plurality of enzymes and coenzyme, alkaloid, the bioactivators such as histamine, and also having in addition special " ant antibiotic " is the Special Anti rhzomorphs such as metathorax side pole parathyrine.
Major function:
1, bone and joint diseases: rheumatoid disease, rheumatic arthritis, scapulohumeral periarthritis, pain in waist and lower extremities.
2, cardiovascular and cerebrovascular disease: coronary heart disease, cerebral embolism sequela, angina pectoris, myocarditis.
3, disease in the urological system: ephritis, impotence, premature ejaculation, frigidity.
4, disease of digestive system: gastritis, indigestion, cholecystitis, hepatitis, liver ascites, cirrhosis.
5, the nervous system disease: neurasthenia, vegetative nerve functional disturbance, insomnia, headache.
6, Other diseases: diabetes, lupus erythematosus, chorionitis, young person with greying hair, loss of tooth, cancer postoperative.
(2), anti-disease, anti-aging plant---vine polyphenol
Vine polyphenol be from grape pip, extract take OPC as main polyphenol compound.Basic research shows that vine polyphenol has multiple pharmacological effect, generation, Direct Acquisition free radical, the biologically active that affect enzyme that can be by suppressing active oxygen, affect that DNA synthesizes and gene expression etc. plays a role; Can suppress non-glycosylation, by regulating blood fat, stabilize plaque and impelling patch to disappear, reduce blood pressure, prevent thrombosis, anti-arrhythmia, protection cardiovascular and cerebrovascular; Have antitumor, prevention gene mutation, radioresistance, antiulcer, antiallergy, anti-inflammatory, the pharmacologically active such as antiviral, antibiotic.Clinical research shows; vine polyphenol can reduce with human body in oxidative stress and non-glycosylation, thereby prevent and treat cardiovascular and cerebrovascular disease, prevent senile dementia, prevent and treat malignant tumour, prevention diabetes and complication, prevent and treat cataract and glaucoma, control allergic inflammation, the beauty treatment of protection beautifying skin, take care of one's teeth, prevent and treat gastrointestinal disease, to prevent and treat the prostatic disorders texts remarkable.
The fruit of grape, root, rattan all can be used as medicine, fruit promoting eruption, the diuresis detoxifcation of can inducing sweat, but root and rattan wines used as antirheumatic, stop blooding, help digestion, detoxifcation, antiabortive, external application can be treated fracture.OPC in the grape distributes in seed at most (60%~70%), is the material that causes the grape wine bitter taste, also is one of main nutrient composition.The main chemical compositions of grape pip mainly contains catechin, OPC class (being the condensed tannin class).
Exceed decades of times with regard to verified its antioxidant effect than VC, VE and green tea as far back as French researcher in 1993.Vine polyphenol wherein (polyphenols) then is distributed widely in seed, pulp, pericarp and the carpopodium of each Plants.Wherein the highest with grape pip, be about 65%-70%.
Vine polyphenol is not single a kind of composition in fact, wherein comprises the compositions such as flavones (flavones), tannin (tannins), coumaric acid (coumarque), catechin, the front anthocyanidin (OPC) of few six benzene.Have strengthen and promote the sanguimotor effect of health capilary, it can protect collagen and the elastomer of skin, prevents that ultraviolet ray is to the injury of skin.The resistance function of protection and enhancing skin histology.
20 century 70s, french chemist, biologist's Maas chief strangle and found vine polyphenol (OTC) in grape pips, and done series of experiments, such as bioavilability test, toxicity test, " three cause " experiment (teratogenesis, carcinogenic, mutagenesis) etc., be used for the exploitation American market.From then on, vine polyphenol is widely used in the health food.
Its Main Function has:
1, it is active to strengthen the basis: mainly comprise anti-oxidant, free radical capture, metal ion huge legendary turtle close, with protein combination etc., this is the basis of its pharmacological action of performance by its structures shape;
2, reduce low-density lipoprotein, increase choleresis, promote triglycerides to descend;
3, strengthen cytoprotection, improve liver detoxification function;
4, dissolve targetedly cytotoxin and prevention Carciuogenesis, grape seed extract (GSPE) has preventive and therapeutic action to the enteric adenoma of adenoma polyp gene mutation;
5, vascular protection effect;
6, organ protection;
7, radiation resistance;
8, other effects: in skin healing and other relevant disease of skin, therapeutic action is arranged.GSPE indicates its treatment potentiality in inflammation and other relevant diseases to the inhibitory action that VCAM-1 expresses.GSPE and micro-use in conjunction have long-term health-care effect.The extract that contains OPC can suppress the colibacillary adhesion of P-type by being combined with bacterium, prevents that bacterium from infecting.
(3), massive planting thing animal secretions elite is in the active material of one---the Changbai Mountain natural propolis
Bee product can be divided into honey, royal jelly, pollen, propolis four large classes, and propolis is one of bee product that wherein medical value is higher.The propolis natural gum that to be honeybee gather from the newborn twig of glue source plant or bark, the compound that forms through adding the bee secretion modulation.It is massive planting thing and animal secretions elite in one, contain abundant physiological activator, such as flavonoids, phenols, terpenes, organic acid and several amino acids, enzyme, vitamin, mineral matter etc.
In recent years, the effect of propolis causes people's concern day by day.Experiment showed, that through scientists years of researches propolis contains 300 Multiple components, the good result of propolis has been brought up in complementary effect between the composition.Because propolis is a kind of natural materials, so that propolis has widely drug action, can not have side effects yet, Here it is, and they are different from the place of the medicine that chemical synthesis process makes.
Topmost composition flavone compound reaches kind more than 40 in the propolis, and its kind and content are very abundant.If everybody notes seeing our daily some treatment hypertension of taking, coronary heart disease, the traditional Chinese medicine ingredients that activates blood circulation and disperses blood clots, just can find wherein to contain flavone compound, it has multiple pharmacological effect.Along with progress of research, find that also the compositions such as terpene compound, lipoid substance in the propolis have the effect that suppresses tumour.Also has synergistic function between the propolis composition.Sum up, the effect of propolis has following a few class:
1, antibacterial action: the flavone compound in the propolis, aromatic acid, aliphatic acid, terpene compound etc. all have inhibitory action to bacterium, fungi, pathogenic bacteria, mould etc.It only needs just many microorganisms are had inhibitory action on a small quantity, but only single microorganism is produced effect unlike antibiotic, and also has side effect.In daily life, if wound is arranged, burn, ulcer etc., we can utilize this of propolis to be used for protecting health not encroached on by germ, reach the effect of anti-inflammation and sterilization.
2, antivirus action: the compositions such as the flavonols in the propolis, flavones, flavanones, caffeic acid derivative all have antiviral effect.Evidence, propolis infected by influenza, vaccinia virus, hepatitis B, herpesviral, bone marrow poliomyelitis virus, vesicle stomatitis virus etc. all have good effect.Now, our living environment degenerates, and is seriously polluted, and some new viruses occur in our unwitting situation, and are diseases induced.Therefore, we can come the preventing viral disease with propolis, reach the purpose that improves the health.
3, antioxidation: the compositions such as the flavone compound in the propolis, glucoside, phenols, terpene compound all have antioxidation.When organism when carrying out oxygen metabolism, can constantly produce refuse---reactive oxygen species and free radicals.It can act on the lipid material in cell membrane and the blood, form MDA, be deposited on the cell membrane, histocyte is wrecked, thereby chromogenesis, color spot, whelk, pachylosis etc., these MDAs also can be deposited on the vascular wall, form thrombus etc., also may cause atherosclerotic and cataract.In addition, it also can resist gamma-radiation irradiation, the side effect that alleviates Radiotherapy chemotherapy.Bad habit in our daily life all can produce the superfluous refuses such as reactive oxygen species and free radicals such as smoking, obesity, pressure, overworked, excessive diet, environmental pollution etc.Because propolis can effectively stop the generation of MDA, have good antioxidation, be called as antioxidant and free radical scavenger.
4, antitumor action: contain abundant antitumorigenic substance in the propolis, such as the Quercetin in the flavone compound, Kaempferol, Galangin, apiolin etc.; Multiple times of terpene in the terpene compound, Diterpenes, triterpenes etc.; Glucoside material in the polysaccharide material; Lignanoid in the naphthoquinone compound; The compositions such as the CAPE in the lipoid substance etc., isoprene ester all have antitumor action.Particularly CAPE, Quercetin, methaform diterpene, Artepilin C composition.Experimental results show that, the synergy of these compositions can not only suppress cancer of the stomach, liver cancer, the isocellular development of lung cancer, can also alleviate the side effect that radiotherapy, chemotherapy bring, this effect has improved result for the treatment of, and propolis do not kill healthy cell when killing cancer cell, and this is the Gospel of tumor patient.Therefore, propolis has pre-preventing tumor, suppresses canceration, kills cancer cell, prevents the effects such as transfer, and do not have the side effect of cancer therapy drug.
5, regulate blood fat, adjusting blood pressure, the effect of adjusting blood sugar: the synergy of propolis composition, can suppress the rising of triglycerides, cholesterolemia, can remove interior free yl, effectively purify the blood, platelet aggregation and thrombosis there are good inhibitory action, thereby reach the purpose of regulating blood fat, regulating blood pressure.Propolis can also promote to utilize exogenous glucose to synthesize hepatic glycogen, to regulating blood sugar good effect is arranged.Various complication to causing because of diabetes particularly, as utilize the anti-inflammation and sterilization effect of propolis, prevent and treat various infection; Utilize propolis to remove the effect of free radical, lipopenicillinase and reduction blood stickiness, can prevent the generation of vascular system disease; The raising immunity of propolis can make people's resistance against diseases strengthen etc.In daily life, utilizing propolis to improve health and prophylactic generation, is very safe, and the side effect that does not have medicine to bring.Now, along with growth in the living standard, the change of dietary structure, so that the disease of this respect becomes younger, a middle-aged person's the ratio of falling ill should cause our enough attention increasing.
6, suppress the effect of analgesia and local anaesthesia: the inhibition analgesia of propolis and the effect of local anaesthesia, on the books very early both at home and abroad.The scientific worker proves that by experiment the local anaesthesia effect of propolis can match in excellence or beauty with other anaesthetics.Use if mix, can make anesthetic effect synergy, also do not have side effect.In life, can be placed on toothache position pain relieving to propolis; Available propolis spreads upon on the wound, plays the effect of anti-inflammatory and analgesic.
7, anti-inflammatory and antiulcer action: propolis has film forming, in antibiotic, antiviral, analgesic activity, has brought into play the effect of anti-inflammatory.It all has good antiinflammation to ENT diseases such as canker sore, periodontitis, bronchitis, pharyngitis, tonsillitis, rhinitis, nasosinusitis, otitis externas.In addition, propolis can form diaphragm on the ulcer surfaces such as gastric ulcer, duodenal ulcer, brings into play simultaneously the effect of sterilization, promotion regeneration, can reach effective antiulcer purpose.Equally, propolis also has good effect to enteritis.In environment now, various pressure, excess ingestion stimulate food, heavy drinking etc. all can cause ulcer to occur, so we should notice that the oneself releases the pressure, and are careful in one's diet, and form good habits and customs.
8, beautification function: because propolis has the effect of anti-inflammatory, promotion regeneration, by regulating endocrine, improving blood circulation state, reach cosmetic purpose.But propolis cosmetics bactericidal antiphlogistic, frost-cracking-preventing, anti-infect etc., respond well to acne.Propolis also has good effect to alopecia.The effect of propolis also more than these, along with the development of science and technology, the effect of propolis also can constantly be found.On the whole, propolis is by the adjusting to the whole body function to people's benefit, enhance metabolism, thereby reach improve the health, the purpose of across-the-board regulation.
9, immunological enhancement: self has immune system human body, in order to resist the infringements such as germ.If immunity is low, with regard to susceptible disease.And the synergy of the composition in the propolis can increase antibody activity, and total serum protein and gamma globulin are increased, and strengthens the phagocytic activity of leucocyte and macrophage, improves body specificity and non-specific immune function.Under the huge environment of current life, operating pressure, the sub-health status such as tired, deficient in energy, insomnia appear easily, cause immunity degradation, and propolis can improve immunity, the enhancing resistance against diseases is improved sub-health status.
Above-mentioned red ant, vine polyphenol and propolis all has single health product on market, but all there is function singleness in they, the shortcoming of poor effect, long-term taking is one or more health products wherein, the ratio that health products are taken because very difficult assurance is respectively distinguished the flavor of, can consume a large amount of money on the one hand, probably cause on the other hand the unbalance situation of endotrophic state, produce certain side effect.
Summary of the invention the purpose of this invention is to provide the composition of a kind of Formica rufa with health care, grape, propolis extract, it takes full advantage of the interaction between red ant, vine polyphenol and the propolis, curative effect is single unilateral when overcoming their independent uses, the shortcoming of poor effect has realized the optimization of care treatment effect.
Composition of the present invention contains red extract from ants, vine polyphenol and propolis extract, the weight of described red extract from ants is the 20%-50% of composition weight, the weight of described vine polyphenol is the 20%-40% of composition weight, and the weight of described propolis extract is the 20%-40% of composition weight.
Preferably, the weight of described red extract from ants is 40% of composition weight, and the weight of described vine polyphenol is 30% of composition weight, and the weight of described propolis extract is 30% of composition weight.
Described red extract from ants is that red ant get the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 3-4.8 times of red ant weight during lixiviate, and extraction time is 40-48 hour, and extraction temperature is 5-30 ℃.Concrete processing technology is, catches the wild red ant and carries out cleaning and sterilizing, soaks with acetone solution, and centrifugation goes out the acetone leaching liquor, the acetone leaching liquor reclaimed oven dry obtain red extract from ants.
Described vine polyphenol is behind the grape pip process alcohol steep alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 40-50 ℃.Concrete processing technology is, collects grape pip and carries out cleaning and sterilizing, the grape pip after the sterilization is pulverized, and the alcohol immersion with 95%, the isolated by filtration alcohol extract reclaims to dry to alcohol extract and obtains vine polyphenol.
Described propolis extract is that propolis is through behind the alcohol steep getting the alcohol extract oven dry, ethanol employing volume fraction is 75% ethanol during lixiviate, its weight is 2-4 times of propolis weight, extraction time is 24 hours, extraction temperature is 40-50 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is 0--5 ℃ after the lixiviate.Concrete processing technology is, collects propolis and carries out fragmentation, and with 75% alcohol immersion, low-temperature centrifugation deleading paraffin removal reclaims to dry to alcohol extract and obtains propolis extract with the propolis after the fragmentation.
The formulation of the present composition is capsule, tablet, granule, pill, powder.Preferred capsule wherein.
The application of the present composition in preparation food or health products.
Compared with prior art, the organic compatibility of optimal proportion that the present invention draws red ant, vine polyphenol and propolis according to test of many times together, the tonic effect of each herbal medicine is mutually promoted, guaranteed on the whole simultaneously the balance picked-up of nutrition, thereby realized the optimization of care treatment effect, reached ill and cure the disease without the purpose of disease and health.Composition of the present invention is contained human body eight large system desired nutritionals, realizes real comprehensive health care, whole body conditioning.
Its comprehensive effect is:
1, repair impaired gene, activating cell improves the cell metabolism level.Fundamentally realize nti-freckle, beauty treatment, beauty treatment;
2, reconcile Endocrine Levels from root, effectively treat diabetes, the prevention complication.Elimination comprises all diseases that produce because of endocrinopathy climacteric.Allow people skip climacteric.
3, improve body immunity, the treatment lupus erythematosus strengthens vivo antitumor factor quantity, and the side effect that produces because of radiotherapy chemotherapy is dissolved in the inhibition tumor cell growth;
4, remove interior free yl, improve cardiac and cerebral blood-supply, effectively solve the diseases such as hypertension, coronary heart disease, myocardial hypertrophy, tachycardia, bradycardia, premature beat, atrial fibrillation, valve incompetence, uncomfortable in chest, angina pectoris, miocardial infarction, cerebral thrombus, cerebral hemorrhage, encephalatrophy, high cholesterol, high fat of blood, artery sclerosis, cardiac insufficiency, cerebral blood supply insufficiency, anaemia;
5, block and kill virus, dissolve the liver nephrotoxin, protect the liver and protect kidney, eliminate cholecystitis, pancreatitis, eliminating liver and gall kidney stone;
6, improve physiology (property) function, prolong physiological longevity, eliminate the diseases such as ephritis, impotence, premature ejaculation, frigidity;
7, promote the growth of intestines and stomach profitable strain, improve digestive function, eradicate gastritis, gastric ulcer, colitis, constipation and other diseases, promote nutrient absorption;
The diseases such as 8, treatment dizziness, insomnia, forgetful, Parkinson, senile dementia, arthritis, rheumatoid disease, osteoproliferation, prostate;
9, strengthen all organ dysfunctions of health, delay senility life-saving.
The specific embodiment
Composition of the present invention contains red extract from ants, vine polyphenol and propolis extract, the weight of described red extract from ants is the 20%-50% of composition weight, the weight of described vine polyphenol is the 20%-40% of composition weight, and the weight of described propolis extract is the 20%-40% of composition weight.
Preferably, the weight of described red extract from ants is 40% of composition weight, and the weight of described vine polyphenol is 30% of composition weight, and the weight of described propolis extract is 30% of composition weight.
Described red extract from ants is that red ant get the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 3-4.8 times of red ant weight during lixiviate, and extraction time is 40-48 hour, and extraction temperature is 5-30 ℃.Concrete processing technology is, catches the wild red ant and carries out cleaning and sterilizing, soaks with acetone solution, and centrifugation goes out the acetone leaching liquor, the acetone leaching liquor reclaimed oven dry obtain red extract from ants.
Described vine polyphenol is behind the grape pip process alcohol steep alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 40-50 ℃.Concrete processing technology is, collects grape pip and carries out cleaning and sterilizing, the grape pip after the sterilization is pulverized, and the alcohol immersion with 95%, the isolated by filtration alcohol extract reclaims to dry to alcohol extract and obtains vine polyphenol.
Described propolis extract is that propolis is through behind the alcohol steep getting the alcohol extract oven dry, ethanol employing volume fraction is 75% ethanol during lixiviate, its weight is 2-4 times of propolis weight, extraction time is 24 hours, extraction temperature is 40-50 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is 0--5 ℃ after the lixiviate.The processing technology of body is, collects propolis and carries out fragmentation, and with 75% alcohol immersion, low-temperature centrifugation deleading paraffin removal reclaims to dry to alcohol extract and obtains propolis extract with the propolis after the fragmentation.
The formulation of the present composition is capsule, tablet, granule, pill, powder.Preferred capsule wherein.
Lixiviate of the present invention, low-temperature centrifugation, formulation preparation method all can adopt correlation technique of the prior art, equipment and parameter except specified otherwise is arranged.
The application of the present composition in preparation food or health products.
A kind of mode of taking of the present invention is prepared into capsule, tablet, granule, pill, the powder of 0.5mg/ grain with composition, takes three or three parts every day.
Further specify below in conjunction with specific embodiment:
Embodiment 1: composition of the present invention contains red extract from ants, vine polyphenol and propolis extract, the weight of described red extract from ants is 20% of composition weight, the weight of described vine polyphenol is 40% of composition weight, and the weight of described propolis extract is 40% of composition weight.
Described red extract from ants is that red ant gets the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 3 times of red ant weight during lixiviate, and extraction time is 40 hours, and extraction temperature is 30 ℃.
Described vine polyphenol is behind the grape pip process alcohol steep alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 40 ℃.
Described propolis extract is that propolis is through behind the alcohol steep getting the alcohol extract oven dry, ethanol employing volume fraction is 75% ethanol during lixiviate, its weight is 2 times of propolis weight, extraction time is 24 hours, extraction temperature is 50 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is 0 ℃ after the lixiviate.
Embodiment 2: composition of the present invention contains red extract from ants, vine polyphenol and propolis extract, the weight of described red extract from ants is 50% of composition weight, the weight of described vine polyphenol is 20% of composition weight, and the weight of described propolis extract is 30% of composition weight.
Described red extract from ants is that red ant gets the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 4.8 times of red ant weight during lixiviate, and extraction time is 48 hours, and extraction temperature is 5 ℃.
Described vine polyphenol is behind the grape pip process alcohol steep alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 50 ℃.
Described propolis extract is that propolis is through behind the alcohol steep getting the alcohol extract oven dry, ethanol employing volume fraction is 75% ethanol during lixiviate, its weight is 2-4 times of propolis weight, extraction time is 24 hours, extraction temperature is 40 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is-5 ℃ after the lixiviate.
Embodiment 3: composition of the present invention contains red extract from ants, vine polyphenol and propolis extract, the weight of described red extract from ants is 40% of composition weight, the weight of described vine polyphenol is 40% of composition weight, and the weight of described propolis extract is 20% of composition weight.
Described red extract from ants is that red ant gets the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 4 times of red ant weight during lixiviate, and extraction time is 44 hours, and extraction temperature is 25 ℃.
Described vine polyphenol is behind the grape pip process alcohol steep alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 45 ℃.
Described propolis extract is that propolis is through behind the alcohol steep getting the alcohol extract oven dry, ethanol employing volume fraction is 75% ethanol during lixiviate, its weight is 2-4 times of propolis weight, extraction time is 24 hours, extraction temperature is 45 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is-3 ℃ after the lixiviate.
Embodiment 4: composition of the present invention contains red extract from ants, vine polyphenol and propolis extract, the weight of described red extract from ants is 40% of composition weight, the weight of described vine polyphenol is 30% of composition weight, and the weight of described propolis extract is 30% of composition weight.
Described red extract from ants is that red ant gets the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 3 times of red ant weight during lixiviate, and extraction time is 40 hours, and extraction temperature is 28 ℃.
Described vine polyphenol is behind the grape pip process alcohol steep alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 48 ℃.
Described propolis extract is that propolis is through behind the alcohol steep getting the alcohol extract oven dry, ethanol employing volume fraction is 75% ethanol during lixiviate, its weight is 3 times of propolis weight, extraction time is 24 hours, extraction temperature is 43 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is-4 ℃ after the lixiviate.
Embodiment 5: composition of the present invention contains red extract from ants, vine polyphenol and propolis extract, the weight of described red extract from ants is 35% of composition weight, the weight of described vine polyphenol is 38% of composition weight, and the weight of described propolis extract is 27% of composition weight.
Described red extract from ants is that red ant gets the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 4.3 times of red ant weight during lixiviate, and extraction time is 42 hours, and extraction temperature is 15 ℃.
Described vine polyphenol is behind the grape pip process alcohol steep alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 47 ℃.
Described propolis extract is that propolis is through behind the alcohol steep getting the alcohol extract oven dry, ethanol employing volume fraction is 75% ethanol during lixiviate, its weight is 2.5 times of propolis weight, extraction time is 24 hours, extraction temperature is 43 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is-2 ℃ after the lixiviate.
Embodiment 6: composition of the present invention contains red extract from ants, vine polyphenol and propolis extract, the weight of described red extract from ants is 28% of composition weight, the weight of described vine polyphenol is 37% of composition weight, and the weight of described propolis extract is 35% of composition weight.
Described red extract from ants is that red ant gets the oven dry of acetone leaching liquor after through the acetone lixiviate, and the weight of acetone is 4.5 times of red ant weight during lixiviate, and extraction time is 46 hours, and extraction temperature is 10 ℃.
Described vine polyphenol is behind the grape pip process alcohol steep alcohol extract oven dry to be got, and ethanol employing volume fraction is 95% ethanol during lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 43 ℃.
Described propolis extract is that propolis is through behind the alcohol steep getting the alcohol extract oven dry, ethanol employing volume fraction is 75% ethanol during lixiviate, its weight is 3.3 times of propolis weight, extraction time is 24 hours, extraction temperature is 49 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is-1 ℃ after the lixiviate.
Experimental example 1: take the Married Men crowd at 35-45 age in year as experimental subjects, choose at random 124 and carry out clinical testing, to being divided into experimental group and control group, each 62, experimental group member takes one of capsule of the present invention (three on the one) morning, noon and afternoon every day, presses embodiment 4 preparations, 3 months courses for the treatment of, the control group morning, noon and afternoon are taken the placebo (food starch) identical with weight outward appearance of the present invention, 3 months courses for the treatment of.
Employing experiment front and back check UP respectively (comprising routine blood test, liver function, myocardial function etc.) and the method for (comprising diet, sleep, the state of mind, sense of fatigue, life quality) of inquiring is added up:
The blood indices has the variation (comprising blood sugar, blood fat, immunocyte quantity) of trend normal value in the experimental group, myocardium indices trend normal value, liver function indices trend normal value; By inquiry, among experimental group 62 people, there are 55 people to represent that diet, sleep, the state of mind, sense of fatigue, life quality have clear improvement, remain 7 people and represent to have slight improvement.
Indices among the control group crowd does not have significant change, inquiry control group member, and all expression does not have significant change.
Experimental example 2: take often near housewife 60 people in 40-50 year of oil smoke as experimental subjects, to being divided into experimental group and control group, every group of each 30 people, experimental group member takes 1 of capsule of the present invention (3 on the one) morning, noon and afternoon every day, press embodiment 1 preparation, be 3 months the course for the treatment of, and control group morning, noon and afternoon every day are taken the placebo (food starch) identical with weight outward appearance of the present invention, 3 months courses for the treatment of.
Experimental group member's facial glossiness all has clear improvement, and wherein, the rejuvenation that 22 Person's skin ages testing results show 5-8 before the experiment is arranged in the experimental group.The control group skin of face does not obviously improve.
Learn that by inquiry experimental group member represents not occur menopause symptom or menopause symptom is obviously improved or disappearance.Obvious menopause symptom appears in 50% above crowd among the control group member.
Experimental example 3: take the Married Men crowd at 35-45 age in year as experimental subjects, choosing at random 70 carries out clinical testing, and per 10 people divide one group, totally 7 groups, comprise 6 experimental group and 1 control group.Experimental group 1-6 takes respectively the composition of embodiment 1-6 preparation, and control group is taken the placebo (food starch) identical with weight outward appearance of the present invention, and morning, noon and afternoon every day are taken 1 of capsule of the present invention (3 on the one), 3 months courses for the treatment of.
Employing experiment front and back check UP respectively (comprising routine blood test, liver function, myocardial function etc.) and the method for (comprising diet, sleep, the state of mind, sense of fatigue, life quality) of inquiring is added up:
The blood indices has the variation (comprising blood sugar, blood fat, immunocyte quantity) of trend normal value in the experimental group, myocardium indices trend normal value, liver function indices trend normal value; By inquiry, the number that every condition in the experimental group (comprising diet, sleep, the state of mind, sense of fatigue, life quality) obviously improves is: experimental group 1 is 8 people, experimental group 2 is 9 people, experimental group 3 is 9 people, experimental group 4 is 10 people, experimental group 5 is 8 people, and experimental group 6 is 9 people, and remaining per capita expression makes moderate progress in each group.
Indices among the control group crowd does not have significant change, inquiry control group member, and all expression does not have significant change.
Experimental example 4: take often near housewife 70 people in 40-50 year of oil smoke as experimental subjects, per 10 people divide one group, totally 7 groups, comprise 6 experimental group and 1 control group.Experimental group 1-6 takes respectively the composition of embodiment 1-6 preparation, and control group is taken the placebo (food starch) identical with weight outward appearance of the present invention, and morning, noon and afternoon every day are taken 1 of capsule of the present invention (3 on the one), 3 months courses for the treatment of.
Experimental group member's facial glossiness all has clear improvement, wherein, skin age testing result shows in each experimental group has the number of the rejuvenation of 5-8 to be before the experiment: experimental group 1 is 9 people, experimental group 2 is 9 people, experimental group 3 is 9 people, experimental group 4 is 10 people, and experimental group 5 is 8 people, and experimental group 6 is 9 people.The control group skin of face does not obviously improve.
Learn that by inquiry experimental group member represents not occur menopause symptom or menopause symptom is obviously improved or disappearance.Obvious menopause symptom appears in 8 people among the control group member.
Can prove that thus composition of the present invention has following health care:
1, repair impaired gene, activating cell improves the cell metabolism level.Fundamentally realize nti-freckle, beauty treatment, beauty treatment;
2, reconcile Endocrine Levels from root, effectively treat diabetes, the prevention complication.Elimination comprises all diseases that produce because of endocrinopathy climacteric.Allow people skip climacteric.
3, improve body immunity, the treatment lupus erythematosus strengthens vivo antitumor factor quantity, and the side effect that produces because of radiotherapy chemotherapy is dissolved in the inhibition tumor cell growth;
4, remove interior free yl, improve cardiac and cerebral blood-supply, effectively solve the diseases such as hypertension, coronary heart disease, myocardial hypertrophy, tachycardia, bradycardia, premature beat, atrial fibrillation, valve incompetence, uncomfortable in chest, angina pectoris, miocardial infarction, cerebral thrombus, cerebral hemorrhage, encephalatrophy, high cholesterol, high fat of blood, artery sclerosis, cardiac insufficiency, cerebral blood supply insufficiency, anaemia;
5, block and kill virus, dissolve the liver nephrotoxin, protect the liver and protect kidney, eliminate cholecystitis, pancreatitis, eliminating liver and gall kidney stone;
6, improve physiology (property) function, prolong physiological longevity, eliminate the diseases such as ephritis, impotence, premature ejaculation, frigidity;
7, promote the growth of intestines and stomach profitable strain, improve digestive function, eradicate gastritis, gastric ulcer, colitis, constipation and other diseases, promote nutrient absorption;
The diseases such as 8, treatment dizziness, insomnia, forgetful, Parkinson, senile dementia, arthritis, rheumatoid disease, osteoproliferation, prostate;
9, strengthen all organ dysfunctions of health, delay senility life-saving.
Claims (8)
1. Formica rufa with health care, grape, the composition of propolis extract, it is characterized in that: described composition is by red extract from ants, vine polyphenol and propolis extract form, described red extract from ants is after the lixiviate of red ant process acetone the oven dry of acetone leaching liquor to be got, described propolis extract is that propolis is through behind the alcohol steep getting the alcohol extract oven dry, the weight of described red extract from ants is the 20%-50% of composition weight, the weight of described vine polyphenol is the 20%-40% of composition weight, and the weight of described propolis extract is the 20%-40% of composition weight.
2. composition according to claim 1, it is characterized in that: the weight of described red extract from ants is 40% of composition weight, the weight of described vine polyphenol is 30% of composition weight, and the weight of described propolis extract is 30% of composition weight.
3. composition according to claim 1 and 2 is characterized in that: during described red extract from ants lixiviate the weight of acetone be red ant weight 3-4.8 doubly, extraction time is 40-48 hour, extraction temperature is 5-30 ℃.
4. composition according to claim 1 and 2 is characterized in that: described vine polyphenol is that grape pip is through behind the alcohol steep getting the alcohol extract oven dry.
5. composition according to claim 4 is characterized in that: to adopt volume fraction be 95% ethanol to ethanol during described vine polyphenol lixiviate, and its weight is 2 times of grape pip weight, and extraction time is 24 hours, and extraction temperature is 40-50 ℃.
6. composition according to claim 1 and 2, it is characterized in that: ethanol employing volume fraction is 75% ethanol during described propolis extract lixiviate, its weight is 2-4 times of propolis weight, extraction time is 24 hours, extraction temperature is 40-50 ℃, and the temperature of low-temperature centrifugation deleading paraffin removal is 0--5 ℃ after the lixiviate.
7. composition according to claim 1 and 2, it is characterized in that: the formulation of described composition is capsule, tablet, granule, pill, powder.
8. the application of composition according to claim 1 and 2 in preparation food or health products.
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CN1537622A (en) * | 2003-10-22 | 2004-10-20 | 吕国安 | Health-care food used for relaxing bowel, anti-senility and beautifying face |
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CN1078143A (en) * | 1993-05-15 | 1993-11-10 | 中国人民解放军空军第四研究所 | XUANJU oral liquid and preparation technology thereof |
CN1126595A (en) * | 1995-10-24 | 1996-07-17 | 宜昌龙台食品工业股份限公司 | Health termite mother liquor and its prepn |
CN1537622A (en) * | 2003-10-22 | 2004-10-20 | 吕国安 | Health-care food used for relaxing bowel, anti-senility and beautifying face |
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