CN109737861A - A kind of adjustable type protein base flexibility strain transducer and preparation method thereof, application - Google Patents
A kind of adjustable type protein base flexibility strain transducer and preparation method thereof, application Download PDFInfo
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- CN109737861A CN109737861A CN201811400012.8A CN201811400012A CN109737861A CN 109737861 A CN109737861 A CN 109737861A CN 201811400012 A CN201811400012 A CN 201811400012A CN 109737861 A CN109737861 A CN 109737861A
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Abstract
The present invention provides a kind of adjustable type protein base flexibility strain transducer and preparation method thereof, application, is related to biomaterial and mechanics sensor technical field.A kind of adjustable type protein base flexibility strain transducer, including the top crown made of conductive protein material and bottom crown flexible.The surface of the top crown has miniature elastic protrusion, and the elastic bumps are arranged in array, and there is the top crown one side of the elastic bumps to contact with the bottom crown.This sensor mechanical property is good, stability and high sensitivity, and good biocompatibility is nontoxic and degradable.The present invention also provides the preparation methods of the sensor, and preparation process is simple, at low cost and be easy to produce in batches, and this sensor has biggish application prospect in pulse detection, respiratory air flow detection, vocal cord vibration detection, joint motions detection.
Description
Technical field
The present invention relates to the technical fields of biomaterial and mechanics sensor, and in particular to a kind of adjustable type protein base is soft
Property strain transducer and preparation method thereof, application.
Background technique
With the development of information-intensive society, technology of Internet of things is constantly progressive, and people are to real time medical monitoring, wearable device
It is growing with the technical need of lightweight mobile electronic device.Pliable pressure sensor can monitor stretching, curved as one kind
The information collection device of the deformation such as bent, distortion, has extensively in fields such as electronic skin, Flexible Displays, health monitoring, man-machine interfaces
Wealthy application space.It is well known that heart rate and pulse frequency are one of important physiology physical sign parameters of human body, it is carried out in real time
Monitoring provides useful physiological health information for user, by the health evaluating and disease (such as cardiovascular system disease to user
Disease) primary prevention have important value.In real time, accurate detection human body is respectively to health indicator, and carries out data to indices
The trend that optimal health care plans are future development is made in analysis in time, in conclusion wearable strain transducer is being cured
Health field is treated, great application potential is shown.
Pliable pressure sensor common at present generallys use such as polymer material, nano material, organic semiconductor material
Material etc. realizes the function of original solid electronic device.Such as 108562219 A of Chinese patent CN 108267078 A and CN
Deng, building on flexible polymer material (polyethyleneimine, dimethyl silicone polymer etc.), with metal nanometer line or carbon materials
Material is used as conductive layer, prepares flexible strain transducer.For the signal acquisition in terms of for biologic medical, the sensor is universal
The problem of having ignored compactness, comfort, degradability and the biocompatibility of flexible sensor, and the sensitivity of sensor
It is all not ideal enough with controllability.Therefore, it is necessary to develop a kind of environmentally friendly flexible biography of novel good mechanical performance
Sensor, can health and fitness information of the real-time detection human body under various moving situations, with further satisfaction mechanics sensor in biology
The needs of practical application in medical treatment.
Summary of the invention
It is an object of the invention to a kind of adjustable type protein base flexibility strain transducers, this sensor mechanical property is good,
Stability and high sensitivity, good biocompatibility are nontoxic and degradable.
Another object of the present invention is to provide a kind of preparation method of adjustable type protein base flexibility strain transducer, systems
Standby process is simple, at low cost and be easy to produce in batches.
Third object of the present invention be to provide above-mentioned adjustable type protein base flexibility strain transducer pulse detection,
Application during respiratory air flow detection, vocal cord vibration detect, joint motions detect, can effectively integrate the fitting of flexible sensor
Degree, comfort, degradability and biocompatibility.
The present invention solves its technical problem and adopts the following technical solutions to realize.
The present invention provides a kind of adjustable type protein base flexibility strain transducer, including made of conductive protein material
Top crown and bottom crown flexible；The surface of the top crown has miniature elastic protrusion, and the elastic bumps are arranged in array,
There is the top crown one side of the elastic bumps to contact with the bottom crown.
Further, the shape of the elastic bumps is one of round, taper or pyramid, and the elasticity is convex
It plays height and is less than or equal to 500 μm.
Further, the pressure measurement range of the strain transducer be 0~4000Pa, the range of sensitivity be 0.3~
1.2kPa-1。
The invention also provides a kind of preparation method of above-mentioned adjustable type protein base flexibility strain transducer, including it is following
Step:
PDMS is poured into the template with array type protrusion, negative template is obtained after solidification by S1；
S2 prepares the top crown: protein, conductive material and compound phase material are mixed to get the conductive protein
The conductive protein material is poured into the negative template, stands, obtain the top crown by material；
S3 prepares the bottom crown: evaporation metal material on a flexible substrate；
S4, respectively in the top crown and the bottom crown extraction wire, by the periphery of the top crown and the lower pole
The periphery of plate bonds, and obtains the strain transducer.
Further, in step s 2, the mass ratio of the protein and the compound phase material is 1~9:1~9.
Further, in step s 2, the quality of the conductive material is the 15% of the conductive protein material quality
~50%.
Further, in step s 2, the protein, which is selected from, chooses one of fibrin, globulin, memebrane protein；
The compound phase material is selected from one of fibrin, globulin, memebrane protein, high molecular material, carbohydrate；Wherein, the egg
White matter is different from the selection of the compound phase material；The conductive material be selected from one of graphene, carbon nanotube, graphite or
It is a variety of.
Further, in step sl, it is micro- to be selected from metal class micro-structure template, silicon microstructure template, ceramics for the template
One of stay in place form or polymer microstructure template；Wherein the metal class micro-structure template is selected from aluminum alloy pattern plate, stainless steel
One of template, titanium template.
Further, in step s3, the flexible substrates are selected from one of fibroin albumen, polyvinyl alcohol, polyurethane；
Institute's metal material is selected from one of copper, silver, gold.
The invention also provides above-mentioned adjustable type protein base flexibility strain transducers to examine in pulse detection, respiratory air flow
It surveys, vocal cord vibration detects, the application in joint motions detection.
A kind of adjustable type protein base flexibility strain transducer of the embodiment of the present invention and preparation method thereof, application it is beneficial
Effect is:
(1) adjustable type protein base flexibility strain transducer provided by the invention, the miniature elastic that top crown has are convex
It rises, strain inductive material has lower sheet resistance, so that the strain transducer acquisition signal sensitivity and signal-to-noise ratio that are prepared
It is high.Protein material used in top crown is prepared simultaneously, makes top crown flexible and toughness with higher, is easy to split leather
Skin, good biocompatibility, biodegradable are substantially non-toxic.And the bottom crown of strain transducer is also by good biocompatibility
Flexible high molecular material be prepared, also have both good flexible, toughness and biocompatibility, be easy to be bonded skin, relax
Adaptive is good.In addition to this, the preparation process of strain transducer provided by the invention does not need high temperature and pressure, environmentally friendly,
Preparation method is simple, and cost is relatively low, is easy to produce in batches.
(2) adjustable type protein base flexibility strain transducer provided by the invention can lead to during preparing top crown
The ratio of regulation protein, composite diphase material and conductive material, or the size and shape of regulation miniature elastic protrusion are crossed, so that system
Mechanical property, electric conductivity and the sensitivity of standby obtained strain transducer are adjustable, the different sensitivity that is prepared and
The strain transducer of measurement range.Therefore, based on this, strain transducer provided by the invention can be applied to different occasions,
Have a wide range of application, operability is high, in biologic medical, before electro-physiological signals detection (pulses measure) aspect has a wide range of applications
Scape.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached
Figure is briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not construed as pair
The restriction of range for those of ordinary skill in the art without creative efforts, can also be according to this
A little attached drawings obtain other relevant attached drawings.
Fig. 1 is the structural schematic diagram for the adjustable type protein base flexibility strain transducer that embodiment 1 provides；
Fig. 2 is the top crown preparation flow figure for the adjustable type protein base flexibility strain transducer that embodiment 1 provides；
Fig. 3 is the SEM of the top crown elastic bumps for the adjustable type protein base flexibility strain transducer that embodiment 1 provides
Figure；
Fig. 4 is the resistance for the adjustable type protein base flexibility strain transducer that embodiment 1 provides with pressure history；
Fig. 5 is resistance of the adjustable type protein base flexibility strain transducer of the offer of embodiment 1 during beat pulse
Change curve.
Icon: 1- top crown；11- elastic bumps；2- bottom crown；21- metal material；3- conducting wire；4- negative template.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, according to normal conditions or manufacturer builds
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
Below to a kind of adjustable type protein base flexibility strain transducer of the embodiment of the present invention and preparation method thereof, application
It is specifically described.
A kind of adjustable type protein base flexibility strain transducer provided in an embodiment of the present invention, including by conductive protein material
Manufactured top crown 1 and bottom crown flexible 2；The surface of the top crown 1 has miniature elastic protrusion 11, the elastic bumps
11 are arranged in array, and there is the top crown 1 one side of the elastic bumps 11 to contact with the bottom crown 2.
Strain transducer with above structure, to the response of strain by the contact resistance of top crown 1 and bottom crown 2
It determines, the mechanical property of top crown 1 and the structure of microarray elastic bumps 11 are an important factor for influencing contact resistance.?
Making the structure of top crown 1 under effects of strain, deformation occurs, so that strain transducer is prepared with lower resistance.This is
Since on the one hand, in deformation process, conductive material is even closer in top crown 1, so that the sheet resistance of conductive material reduces.It is another
Aspect, effects of strain makes the miniature elastic protrusion of top crown 1, and 11 deformation occurs, and miniature elastic protrusion 11 connects with bottom crown 2
Contacting surface product increases, so that the resistance of strain transducer reduces.And top crown 1 and bottom crown 2 are by the flexibility of good biocompatibility
Material is made, good with skin attachement, and comfort is high, and material therefor is nontoxic, environmentally friendly
Further, the shape of the elastic bumps 11 is one of round, taper or pyramid, the elasticity
Raised 11 height are less than or equal to 500 μm.The miniature elastic protrusion 11 is size bulge-structure below in the micron-scale, deformation
In the process, miniature elastic protrusion 11 and the contact area of bottom crown 2 increase, so that the resistance of strain transducer reduces.
Further, the pressure measurement range of the strain transducer be 0~4000Pa, the range of sensitivity be 0.3~
1.2kPa-1.Sensitivity is to indicate a kind of physical quantity of sensor performance, and sensitivity is higher, and sensor performance is better.And it is of the invention
The strain transducer measurement range of offer is wide, performance is stable, high sensitivity.
The invention also provides a kind of preparation method of above-mentioned adjustable type protein base flexibility strain transducer, including it is following
Step:
S1 pours into PDMS in the template with array type protrusion, and negative template 4 is obtained after solidification.
Further, in step sl, it is micro- to be selected from metal class micro-structure template, silicon microstructure template, ceramics for the template
One of stay in place form or polymer microstructure template；Wherein the metal class micro-structure template is selected from aluminum alloy pattern plate, stainless steel
One of template, titanium template.
In a preferred embodiment of the present invention, the step of negative template 4 are as follows: first pour into PDMS with hemispherical or half cone
In the metal class micro-structure template of shape protrusion, wherein hemispheric diameter is 70~90 μm, taken out after to be solidified, so that it may obtain
The negative template 4 of miniature elastic protrusion 11 with hemispherical or half-cone.
S2 prepares the top crown 1: protein, conductive material and compound phase material are mixed to get the conductive albumen
The conductive protein material is poured into the negative template 4, stands, obtain the institute with miniature elastic protrusion 11 by material
State top crown 1.
Further, the protein, which is selected from, chooses one of fibrin, globulin, memebrane protein.The present invention compared with
In good embodiment, the albumen such as fibroin albumen, wool keratin, bovine serum albumin, collagen are can be selected wherein in the protein
It is a kind of.
Further, the compound phase material is in fibrin, globulin, memebrane protein, high molecular material, carbohydrate
It is a kind of；Wherein, the protein is different from the selection of the compound phase material.For example, the protein selects fibrin, then
The compound phase material is selected from one of globulin, memebrane protein, high molecular material, carbohydrate.The high molecular material, carbohydrate can
Select polyvinyl alcohol, chitosan, cellulose etc..
Further, the conductive material is selected from one of graphene, carbon nanotube, graphite or a variety of.In the present invention
In preferred embodiment, if the conductive material selects carbon nanotube, length need to be less than 8 μm, too long carbon nanotube dispersion
Poor, the electric conductivity for easily leading to conductive material is uneven.
Above-mentioned protein, conductive material and compound phase material be mixed to get conductive protein material sheet resistance be about 310 Ω/
Sq~360 Ω/sq.The electric conductivity of the top crown 1 is provided by conductive material, the mechanical property and mechanical response of top crown 1
Then network structure is formed by by protein material and compound phase material to determine.It therefore can be by adjusting protein, complex phase material
The ratio of material and conductive material, the strain transducer of different sheet resistances is prepared, applied to different fields.
Further, the mass ratio of the protein and the compound phase material is 1~9:1~9.Regulatory protein can be passed through
Ratio between matter and compound phase material, to adjust the mechanical property of the top crown 1.For example, the protein with it is described multiple
When the mass ratio for closing phase material is 2~9:1,1 intensity of top crown being prepared is more preferable.And when the protein with it is described compound
When the mass ratio of phase material is 1:2~9, the ductility for the top crown 1 being prepared is more preferable, and quality is more soft.
Further, in step s 2, the quality of the conductive material is the 15% of the conductive protein material quality
~50%.It can be by the content of conductive material in top crown 1, to adjust the electric conductivity of the top crown 1.When conductive albumen
Conductive material content in material is higher, and 1 electric conductivity of top crown being prepared is better, and resistance is lower；Conversely, conductive
Material content is lower, and poorly conductive, resistance are high.
S3 prepares the bottom crown 2: evaporation metal material 21 on a flexible substrate.
Further, in step s3, the flexible substrates are selected from one of fibroin albumen, polyvinyl alcohol, polyurethane；
Institute's metal material 21 is selected from one of copper, silver, gold.In a preferred embodiment of the present invention, the good fibroin egg of flexibility is selected
It is white to be used as flexible substrates, select the silver with excellent conductive performance to be vaporized on flexible substrates.
The preparation step of the bottom crown 2 are as follows: be added a small amount of plasticiser in silk fibroin protein solution, the plasticiser can be with
For glycerine, additive amount 10mg/ml, plasticiser can help silk fibroin protein solution to be easier to condensation film forming.Then by fibroin egg
White solution pours into planar hydrophobic template, and solidification is stood under conditions of 20~30 DEG C of temperature, humidity 40-60%, obtains mechanics
Silk composite membrane of good performance.Then by mask method, silver electrode is deposited on silk composite membrane, so that it may obtain bottom crown
2。
S4, respectively in 2 extraction wire 3 of the top crown 1 and the bottom crown, by the periphery of the top crown 1 and described
The periphery of bottom crown 2 bonds, and obtains the strain transducer.
It is to be appreciated that in the periphery of the top crown 1 and the periphery adhesion process of the bottom crown 2, first by upper pole
The miniature elastic protrusion 11 of plate 1 is after the placement of bottom crown 2, the one side of elastic bumps 11 and bottom crown 2 with metal material 21
Contact, is then bonded the periphery of top crown 1 and bottom crown 2 with glue.Position with miniature elastic protrusion 11
Glue cannot be adhered to, the sensitivity for influencing strain transducer is avoided.
The invention also provides above-mentioned adjustable type protein base flexibility strain transducers to examine in pulse detection, respiratory air flow
It surveys, vocal cord vibration detects, the application in joint motions detection.This is because adjustable type protein base flexibility provided by the invention is answered
Become sensor, it can be miniature by the ratio of regulation protein, composite diphase material and conductive material, or regulation preparing top crown 1
The size and shape of elastic bumps 11, so that the mechanical property for the strain transducer being prepared, electric conductivity and sensitivity are equal
It can be controlled to adjust, the strain transducer of the different measurement ranges and sensitivity that can be prepared.Therefore, as base
Plinth, strain transducer provided by the invention can be applied to different occasions, have a wide range of application, and operability is high, raw in biologic medical
It has a wide range of applications in terms of reason electrical signal detection (pulses measure).
Feature and performance of the invention are described in further detail with reference to embodiments.
Embodiment 1
The embodiment of the present invention provides a kind of adjustable type protein base flexibility strain transducer, follows the steps below system
It is standby:
(1) it prepares negative template: first pouring into PDMS in the aluminium alloy micro-structure template with hemispherical or half-cone protrusion,
Wherein hemispheric diameter is 80 μm, takes out after to be solidified, obtains the negative template with hemispherical miniature elastic protrusion.
(2) top crown is prepared:
1) it prepares silk fibroin protein solution: by natural silk cocoon after cleaning, taking 15g silk cocoon, steep 30min with warm water, repeat 3
Silk cocoon and 15g sodium bicarbonate and 3L deionized water are heated to boiling after secondary, degumming 30min.Then it is put into magnetic in 4L distilled water
Power stirs 30min, and the silk after obtaining degumming, drying obtains fibroin fiber under the conditions of being placed in 60 DEG C.After taking 5g degumming
Fibroin fiber, by 1 ︰ 6 mass ratio be added lithium-bromide solution, be placed in 4h in 60 DEG C of baking ovens and sufficiently dissolve.It will dissolution
Silk fibroin protein solution afterwards, which is placed in bag filter, obtains fibroin albumen wherein changing a water every 2h with deionized water dialysis 48h
Solution.
2) prepare wool keratin solution: natural wool is used acetone extract 2 hours in soxhlet extraction instrument, then by anhydrous second
Alcohol extracts 2 hours, to remove grease and impurity, is washed with deionized water rear natural air drying, the segment being cut into.Weigh nine water of 2.4g
It closes vulcanized sodium, 24g urea and 1.44g lauryl sodium sulfate and 5g washs the wool finished and is configured in 50ml mixed solution,
8h is dissolved under the conditions of being placed in 60 DEG C obtains initial soln.Initial soln is placed in bag filter and uses deionized water dialysis 72h,
A water is changed every h, obtains wool keratin solution.
3) carbon nano-tube solution is added after mixing silk fibroin protein solution, wool keratin solution and obtains mixed solution.Its
In, the mass ratio of fibroin albumen and wool keratin is 8:2 in mixed solution, and the mass fraction of carbon nanotube is 30%.
4) mixed solution is poured into negative template, is stood under conditions of 30 DEG C of temperature, relative humidity 40%, after solidification
To the top crown of the hemispherical elastic bumps with 80 μm of height, the SEM photograph institute of the structure of hemispherical elastic bumps such as Fig. 3
Show.
(3) bottom crown is prepared:
After a small amount of glycerol is added in silk fibroin protein solution, pour into planar hydrophobic template, it is relatively wet at 30 DEG C of temperature
Solidification is stood under conditions of degree 40%, obtains silk composite membrane.Then by mask method, silver electricity is deposited on silk composite membrane
Pole obtains bottom crown.
(4) extraction wire on top crown obtained above and bottom crown respectively, then will be upper using transparent watertight glue
The periphery bonding of the periphery and bottom crown of pole plate, obtains the strain transducer.
Through measuring, the sensitivity of protein base flexibility strain transducer is in 0.47 kPa provided by embodiment 1-1Left and right,
Pressure measurement range is in 0~2000Pa.
Embodiment 2
The embodiment of the present invention provides a kind of adjustable type protein base flexibility strain transducer, in place of the difference of embodiment 1
It is:
When step (2) prepares top crown, weighed in its step 2) 0.95g Sodium Sulphate Nine Hydroxide, 21g urea and
The wool that 0.4g lauryl sodium sulfate and 5g washing finish is configured in 50ml mixed solution, molten under the conditions of being placed in 60 DEG C
Solution 8h obtains initial soln.Initial soln is placed in bag filter and uses deionized water dialysis 72h, a water is changed every h, obtains sheep
Feather keratin solution.The angle wool keratin extracted according to the method has longer strand.
When step (2) prepares top crown, in its step 3), by silk fibroin protein solution, wool keratin solution
Carbon nano-tube solution is added after mixing and obtains mixed solution.Wherein, in mixed solution fibroin albumen and wool keratin quality
Than being 30% for the mass fraction of 9:1, carbon nanotube.
When step (3) prepares bottom crown, flexible substrates of the PVA film as bottom crown then pass through mask
Silver electrode is deposited in method on PVA film, obtains bottom crown.
Through measuring, the sensitivity of protein base flexibility strain transducer is in 0.67 kPa provided by embodiment 1-1Left and right,
Pressure measurement range is in 0~1500Pa.
Embodiment 3
The embodiment of the present invention provides a kind of adjustable type protein base flexibility strain transducer, in place of the difference of embodiment 1
It is:
When step (2) prepares top crown, wool keratin solution is replaced into bovine serum egg in its step 2)
White solution, is made according to the following steps: 0.5g bovine serum albumin being added in 10ml deionized water, ox is obtained after ultrasonic dissolution
Haemocyanin solution.
When step (2) prepares top crown, in its step 3), by silk fibroin protein solution, bovine serum albumen solution
Carbon nano-tube solution is added after mixing and obtains mixed solution.Wherein, in mixed solution fibroin albumen and bovine serum albumin quality
Than being 30% for the mass fraction of 7:3, carbon nanotube.
Embodiment 4
The embodiment of the present invention provides a kind of adjustable type protein base flexibility strain transducer, in place of the difference of embodiment 1
It is:
PDMS is poured into the silicon substrate taper template that height is 500 μm in step (1), is taken out after to be solidified, obtains that there is cone
The negative template of shape elastic bumps.
When step (2) prepares top crown, in its step 4), mixed solution is poured into negative template, in temperature
It 30 DEG C, stands under conditions of relative humidity 40%, the upper pole with height for 500 μm of cone shaped elastic protrusion is obtained after solidification
Plate.
Test example 1
The sensitivity for the adjustable type protein base flexibility strain transducer that embodiment 1 provides is tested.30~60
Under the conditions of DEG C, measured using the resistance of 2450 pair of strain sensors of Keithley.Shown in result figure 4.
Fig. 4 is illustrated under the minimal stress effect that range is 0~2000Pa, adjustable type protein base in case study on implementation 1
The resistance variations trend of flexible strain transducer.As can be seen from the results, with the biography that the increase of stress, embodiment 1 provide
The resistance of sensor is gradually reduced, and for entire resistance change curves close to line style, the linearity is good, to reflect the offer of case study on implementation 1
Transducer sensitivity it is high.
Test example 2
Carry out pulse test test to the adjustable type protein base flexibility strain transducer that embodiment 1 provides.It will implement
The adjustable type protein base flexibility strain transducer that example 1 provides is attached at wrist pulse, is applied constant pressure, is then used
The resistance of 2450 pair of strain sensors of Keithley measures.Shown in result figure 5.
Fig. 5 illustrates the adjustable type protein base flexibility strain transducer of the offer of case study on implementation 1 during beat pulse
Resistance change curves.As can be seen from the results, with the adjustable type protein that the bounce of human pulse, embodiment 1 provide
The resistance of base flexibility strain transducer changes therewith, and P-wave and D-wave occur, the two represent the spy of pulse wave
Peak is levied, the adjustable type protein base flexibility strain transducer for illustrating that case study on implementation 1 provides can be obtained from data collected
The information of pulse wave has a wide range of applications in terms of biologic medical, electro-physiological signals detection (pulses measure).
Embodiments described above is a part of the embodiment of the present invention, instead of all the embodiments.Reality of the invention
The detailed description for applying example is not intended to limit the range of claimed invention, but is merely representative of selected implementation of the invention
Example.Based on the embodiments of the present invention, obtained by those of ordinary skill in the art without making creative efforts
Every other embodiment, shall fall within the protection scope of the present invention.
Claims (10)
1. a kind of adjustable type protein base flexibility strain transducer, which is characterized in that including made of conductive protein material
Top crown and bottom crown flexible；The surface of the top crown has miniature elastic protrusion, and the elastic bumps are arranged in array,
There is the top crown one side of the elastic bumps to contact with the bottom crown.
2. adjustable type protein base flexibility strain transducer according to claim 1, which is characterized in that the elastic bumps
Shape be one of round, taper or pyramid, the elastic bumps height is less than or equal to 500 μm.
3. adjustable type protein base flexibility strain transducer according to claim 1, which is characterized in that the strain sensing
The pressure measurement range of device is 0~4000Pa, and the range of sensitivity is 0.3~1.2kPa-1。
4. a kind of preparation method of the adjustable type protein base flexibility strain transducer as described in claims 1 to 3 any one,
Characterized by comprising the following steps:
PDMS is poured into the template with array type protrusion, negative template is obtained after solidification by S1；
S2 prepares the top crown: protein, conductive material and compound phase material are mixed to get the conductive albumen material
The conductive protein material is poured into the negative template, stands, obtain the top crown by material；
S3 prepares the bottom crown: evaporation metal material on a flexible substrate；
S4, respectively in the top crown and the bottom crown extraction wire, by the periphery of the top crown and the bottom crown
Periphery bonding, obtains the strain transducer.
5. the preparation method of adjustable type protein base flexibility strain transducer according to claim 4, which is characterized in that
In step S2, the mass ratio of the protein and the compound phase material is 1~9:1~9.
6. the preparation method of adjustable type protein base flexibility strain transducer according to claim 4, which is characterized in that
In step S2, the quality of the conductive material is the 15%~50% of the conductive protein material quality.
7. the preparation method of adjustable type protein base flexibility strain transducer according to claim 4, which is characterized in that
In step S2, the protein, which is selected from, chooses one of fibrin, globulin, memebrane protein；The compound phase material is selected from
One of fibrin, globulin, memebrane protein, high molecular material, carbohydrate；Wherein, the protein and the composite photo material
The selection of material is different；The conductive material is selected from one of graphene, carbon nanotube, graphite or a variety of.
8. the preparation method of adjustable type protein base flexibility strain transducer according to claim 4, which is characterized in that
In step S1, the template is selected from metal class micro-structure template, silicon microstructure template, ceramic microstructures template or the micro- knot of macromolecule
One of structure template；Wherein the metal class micro-structure template is selected from one of aluminum alloy pattern plate, Stainless Molding Board, titanium template.
9. the preparation method of adjustable type protein base flexibility strain transducer according to claim 4, which is characterized in that
In step S3, the flexible substrates are selected from one of fibroin albumen, polyvinyl alcohol, polyurethane；Institute's metal material be selected from copper,
One of silver, gold.
10. the adjustable type protein base flexibility strain transducer as described in claims 1 to 3 any one in pulse detection, exhale
Application during inspiratory flow detection, vocal cord vibration detect, joint motions detect.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113074779A (en) * | 2021-03-25 | 2021-07-06 | 山西大学 | Preparation method of temperature and humidity sensitive material |
| CN113252081A (en) * | 2021-05-12 | 2021-08-13 | 电子科技大学 | Flexible composite sensor based on fibroin and preparation method thereof |
| CN114076785A (en) * | 2020-08-11 | 2022-02-22 | 北京化工大学 | Sensor based on MXene/silk fibroin material and preparation method and application thereof |
| CN114739561A (en) * | 2022-06-09 | 2022-07-12 | 之江实验室 | Anti-sweat-moisture flexible pressure sensor based on fibroin and method and application thereof |
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