CN109717860A - A kind of laser speckle blood flow velocity change detecting method and its device - Google Patents
A kind of laser speckle blood flow velocity change detecting method and its device Download PDFInfo
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Abstract
The invention discloses a kind of laser speckle blood flow velocity change detecting method and its devices, the detection method uses laser speckle blood current imaging technology, blood flow velocity mean value before acquisition laser therapy with lesions position region after laser therapy and normal portions region respectively, by the difference of lesions position region and normal portions region blood flow velocity mean value again compared with the blood flow velocity mean value in the normal portions region, thus to obtain the first blood flow changing value before laser therapy and the second blood flow changing value after laser therapy.The present invention uses laser speckle photography method real-time monitoring blood flow velocity, the development and change situation of keloid is judged by the blood flow velocity variation of different phase, this method observes the blood flow state of microcirculation in real time, without contrast agent, it is not necessarily to scanning, noninvasive and non-contact, by judging the variation of keloid patients' blood flow velocity after laser therapy, accurate judgment basis is provided for the objective diagnosis of the keloid state of an illness.
Description
Technical field
The present invention relates to a kind of laser speckle blood flow velocity change detecting method and its devices, belong to laser detection field.
Background technique
Scar is the inevitable outcome to heal after human skin wound, if finally tending to be tiny smooth, color is close to normal
Skin, then referred to as physiological scar, conversely, be pathologic scar with thickening, hyperplasia, discoloration, the even symptoms such as pain,
And its Pathogenesis remaims unknown.Keloid is a kind of pathologic scar, and paraplasm is obvious, is filled with blood vessel hyperplasia and significantly
Blood, to the judge of its state of an illness or therapeutic effect at present still based on subjective judgement, according to thickness, color and the suppleness of scar,
Such as " Vancouver size table " (coloration calmness, redness degree, flexibility and height), " Manchester evaluation form " (scar surface, side
Edge height, thickness, color and color) etc..Keloid influences patient's appearance, with pain, continue to deteriorate can cause ulcer and
Canceration is at present laser therapy to its emerging therapeutic means, causes photothermy that can induce in keloid upon laser irradiation
Abnormal vascular is degenerated, and then accelerates the degeneration of keloid, achievees the effect that inhibit keloid.
Laser speckle blood current imaging (laser speckle flowgraphy, LSFG) technology is also referred to as laser speckle and contrasts point
(laser speckle contrast analysis, the LSCA) technology of analysis, the principle of laser speckle blood current imaging technology are to utilize
Red blood cell moves the backward dynamic speckle contrast value of generation to obtain blood flowing speed information in blood vessel, therefore passes through imaging mode
The high-resolution blood distribution image of two dimension that the whole audience can be obtained, does not need to combine mechanical scanning, does not need injection external source yet
Property substance, so that it may realize for a long time and successional blood flow monitor.In conjunction with CCD camera and high performance concurrent operation
Equipment can reach the temporal resolution of millisecond magnitude and the spatial resolution of micron dimension.The technology is using a kind of without scanning
Whole-field optically imaging method, can to blood flow change carry out quantitative analysis.The experience of existing clinical use at present, including postoperative blood
Flow imaging monitoring, collection of tumour data etc., which can be used for carrying out all types of blood flow detections.Therefore consider to dissipate with laser
Based on spot blood flow imaging technology, a kind of laser speckle blood flow velocity change detecting method and detection device are developed.
Summary of the invention
In view of the above-mentioned problems existing in the prior art, the purpose of the present invention is obtain a kind of laser speckle blood flow velocity variation
Detection method and its device.
For achieving the above object, the technical solution for the laser speckle blood flow velocity change detecting method that the present invention uses
It is as follows:
A kind of laser speckle blood flow velocity change detecting method, the detection method use laser speckle blood current imaging skill
Art obtains the blood flow velocity mean value in lesions position region and normal portions region before laser therapy, by lesions position region respectively
With the difference of normal portions region blood flow velocity mean value again compared with the blood flow velocity mean value in the normal portions region, obtains and swashing
The first blood flow changing value before light treatment；Again respectively obtain laser therapy after lesions position region and normal portions region blood flow
Speed mean value；By the difference in lesions position region and normal portions region blood flow velocity mean value corresponding before and after laser therapy
Again compared with the blood flow velocity mean value in the normal portions region, the second blood flow changing value after laser therapy is obtained.
Normal portions region refers to the normal skin of keloid periphery no exceptions hyperplasia, and lesions position is abnormal increases
Raw keloid.That is, by comparison normal skin and keloid blood flow velocity, and with normal blood flow velocity
It compares, obtains the situation of change of the blood flow velocity at keloid, the blood flow situation of change before and after laser therapy can be with
The judgement of auxiliary is made for the effect of laser therapy.Wherein all blood flow velocity are the flow velocity mean value in selection region, just
In obtaining more accurate result.Pretherapy and post-treatment blood flow changing value is ratio, characterizes blood flow velocity under pretherapy and post-treatment skin
Opposite variation, further logical operation, such as subtraction can also be carried out between the ratio, be blood flow velocity under long-term skin
Variation monitoring analysis provides data and supports.
Preferably, the laser therapy include: using 585nm/595nm pulsed dye laser or dot matrix CO2 laser or
Er:YAG laser irradiation lesions position.
Preferably, the detection method includes the following steps:
A) the lesions position region in the synchronous irradiation normal portions region and untreated of speckle laser light source, obtains basis and dissipates
Spot image, and blood-stream image is obtained using basis speckle image described in laser speckle blood current imaging technical treatment；
B) in the blood-stream image that step a) is obtained, the corresponding any region R1 of lesions position and normal portions are selected
Corresponding any region R2, the blood flow velocity that analysis obtains in the blood flow velocity mean value V1 and region R2 in the R1 of region respectively are equal
Value V2；
C) laser therapy is carried out to lesions position, the blood-stream image after being treated in a manner of step a) after treatment, then
Any lesions position region R3 and any normal portions region R4 are selected from the blood-stream image after laser therapy, are analyzed respectively
To the blood flow velocity mean value V4 in the blood flow velocity mean value V3 and region R4 in the R3 of region；
D) according to formula (V1-V2)/V2, lesions position is calculated before laser therapy with respect to the first blood flow of normal portions
Lesions position is calculated after laser therapy with respect to the second lectin from hemolymph of normal portions according to formula (V3-V4)/V4 in changing value
Change value.
It compares pretherapy and post-treatment blood flow velocity, calculates (V1-V2)/V2, first blood flow changing value its value is bigger to illustrate scar
Pimple affected area hyperemia is more serious, and it is big that scar continues hyperplasia possibility；(V3-V4)/V4 is calculated, second blood flow changing value its value is got over
Novel Mingzhi's therapeutic effect is more significant, and keloid degeneration possibility is big.
Preferably, described V1, V2, V3 and V4 are expressed as all pixels point flow speed value in its one-to-one region
Mean value.
When being irradiated with speckle laser light source, in order to keep the accuracy of data, used in normal portions and lesions position
Identical processing and sample mode.That is, speckle laser light source irradiates normal portions and lesions position simultaneously, obtain
Basic speckle image be converted to blood-stream image, selected in the speckle image of same blood flow basis any normal portions region and appoint
Blood flow velocity is analyzed in one lesions position region, obtains the blood flow velocity mean value in lesions position region and normal portions region.
The unlimited but pretherapy and post-treatment normal portions region in pretherapy and post-treatment normal portions region and lesions position regional choice
R1 and R3 can be same area, and lesions position region R2 and R4 can be same area.It is accurate as far as possible in order to guarantee to obtain
Blood flow velocity variation, normal portions region can reduce as far as possible at a distance from lesions position region.
The calculation method of the blood flow velocity of blood-stream image is as follows, calculates lining ratio K (x, y) using formula (1), whereinFor strength mean value of the pixel on spatial neighborhood or time neighborhood that collected image coordinate is at (x, y), then σ
(x, y) is the intensity variance value in same vicinity；It carries out that coordinate is calculated to be the pixel at (x, y) using formula (2) and (3)
Flow speed value V (x, y), wherein c be correction constant relevant to measuring device.
V (x, y)=c/ τc (3)。
Flow velocity mean value in analyzed area can also be obtained by other calculation methods and formula, as long as laser can be obtained
The variation of pretherapy and post-treatment blood flow velocity.Preferred calculation formula should not be used as limitation of the invention in this method.
It is a further object of the present invention to provide a kind of dresses using above-mentioned laser speckle blood flow velocity change detecting method
It sets, described device includes speckle laser light source, photoelectronic imaging component, data analysis module and treats laser light source, wherein speckle
Laser light source is used for irradiated lesion position and normal portions, the laser receipts of photoelectronic imaging collect components lesions position and normal portions
Collect basis of formation speckle image；Basic speckle image obtains after data analysis module is using the analysis of laser speckle blood current imaging technology
The blood flow velocity mean value in lesions position region and normal portions region before laser therapy, calculate first before obtaining laser therapy
Blood flow changing value；It treats laser light source and is used for irradiation treatment lesions position, irradiated by speckle laser light source through treating after treatment
Lesions position and normal portions, analyzed by data analysis module after the speckle image of photoelectronic imaging collect components basis, obtained again
The blood flow velocity mean value in lesions position region and normal portions region is taken, the second blood flow changing value after obtaining laser therapy.
Preferably, the speckle laser light source is semiconductor laser；The treatment laser light source includes 585nm/595nm
Pulsed dye laser, dot matrix CO2 laser, any one in Er:YAG laser.
Preferably, the photoelectronic imaging component is the camera or video camera that analog-to-digital conversion is not less than 12.Camera or camera shooting
Machine can choose monochromatic face battle array digital CCD or monochromatic face battle array digital CMOS sensor.
Preferably, data analysis module is specifically used for: the basis of lesions position before and after laser therapy and normal portions is dissipated
Spot image is converted into blood-stream image, and the corresponding any region of lesions position and normal portions corresponding are selected in blood-stream image
One region calculates the blood flow velocity mean value in the lesions position region He the normal portions region, further according to blood flow velocity mean value meter
Calculate blood flow changing value.
A kind of detection system for keloid, the system comprises such as above-mentioned apparatuses.
Preferably, described device respectively detects the blood flow changing value of the keloid before treatment and after treatment.
Detection method and device of the invention can be used for otherwise blood flow variation detection, all to use above-mentioned detection
The method that thinking is compared judgement to the variation of blood flow velocity is considered as falling under the scope of the present invention.
Compared with prior art, the present invention uses laser speckle photography method real-time monitoring blood flow velocity, passes through the blood of different phase
Rheology judges that the development and change situation of keloid, this method observe the blood flow state of microcirculation in real time, without contrast agent,
Without scanning, it is noninvasive and non-contact.It is scar by judging the variation of keloid patients' blood flow velocity after laser therapy
The objective diagnosis of the trace pimple state of an illness provides accurate judgment basis.
Detailed description of the invention
Fig. 1 is testing process schematic diagram of the invention；
Fig. 2 is the device of the invention schematic diagram；
Fig. 3 is sampling analysis figure before the embodiment of the present invention laser therapy；
Fig. 4 is the embodiment of the present invention laser therapy post-sampling analysis chart；
Appended drawing reference
1, speckle laser light source；2, photoelectronic imaging component；3, data analysis module；4, laser light source is treated.
Specific embodiment
Further detailed to laser speckle blood flow velocity change detecting method provided by the invention work below with reference to embodiment,
Completely illustrate.The embodiments described below is exemplary, and for explaining only the invention, and should not be understood as to of the invention
Limitation.
Experimental method in following embodiments is unless otherwise specified conventional method.Reality as used in the following examples
It tests material unless otherwise specified, is that market is commercially available.
As shown in Figure 1 to Figure 2, the invention proposes a kind of device of laser speckle blood flow velocity change detecting method, packets
Speckle laser light source 1, photoelectronic imaging component 2, data analysis module 3 and treatment laser light source 4 are included, wherein speckle laser light source 1
Emit laser irradiation lesions position and normal portions, photoelectronic imaging component 2, which is collected, is radiated at swashing for lesions position and normal portions
Light collects basis of formation speckle image, and basic speckle image handles through data analysis module 3 and obtains blood-stream image, obtains laser and controls
The blood flow velocity mean value in lesions position region and normal portions region before treating calculates the first blood flow variation before obtaining laser therapy
Value；It treats laser light source 4 and is used for irradiation treatment lesions position, emit laser irradiation again by speckle laser light source 1 after treatment
By the lesions position and normal portions of laser therapy, photoelectronic imaging component 2, which is collected, is radiated at lesions position and normal portions
Laser collects basis of formation speckle image, and basic speckle image handles through data analysis module 3 and obtains blood-stream image, obtains laser
The blood flow velocity mean value in rear lesions position region and normal portions region is treated, the second blood flow variation after obtaining laser therapy
Value.Use semiconductor laser for speckle laser light source in the present embodiment, semiconductor laser projects laser and irradiates after expanding
Lesions position, and guarantee that lesions position is completely covered by ray beam.Photoelectronic imaging component 2 is that analog-to-digital conversion is not less than 12
Camera or video camera, camera or video camera can choose monochromatic face battle array digital CCD or monochromatic face battle array digital CMOS sensor.It controls
Laser light source 4 is treated using pulsed dye laser, dot matrix CO2 laser or the Er:YAG laser irradiation lesions position of 585nm/595nm.
The detection method of the present embodiment is divided into before treatment and two parts after treatment, selects any place's lesion group respectively before treatment
Tissue region R1 and any normal tissue regions R2, selected areas must appear in simultaneously in the visual field of blood-stream image.Selected areas
After R1, R2 are irradiated by speckle laser light source 1, the laser of detected part is collected basis of formation speckle pattern by photoelectronic imaging component 2
Basic speckle image processing is obtained blood-stream image through data analysis module 3 by picture；It is the preceding disease for the treatment of with the flow velocity mean value V1 in R1
Blood flow velocity mean value at stove is normal blood flow rates mean value before treating with the flow velocity mean value V2 in R2.By treating laser light source 4
After irradiation treatment, reselection any place's lesion tissue region R3 and any normal tissue regions R4, selected areas R3, R4 are by dissipating
After spot laser light source 1 irradiates, the laser of detected part is collected the speckle image after forming treatment by photoelectronic imaging component 2, through number
The speckle image processing after treatment is obtained into blood-stream image according to analysis module 3, is lesion after treating with the flow velocity mean value V3 in R3
Locate blood flow velocity mean value, is normal blood flow rates mean value after treating with the flow velocity mean value V4 in R4.Compare pretherapy and post-treatment blood flow
Speed calculates (V1-V2)/V2, i.e. the first blood flow changing value, first blood flow changing value its value is bigger to be illustrated at keloid lesion
Congested more serious, it is big that scar continues hyperplasia possibility；Calculate (V3-V4)/V4, i.e. the second blood flow changing value, the variation of the second blood flow
It is worth that its value is smaller to illustrate that therapeutic effect is more significant, keloid degeneration possibility is big.
Wherein, data analysis module is specifically used for:
Before treatment: blood-stream image is converted by the basic speckle image of lesions position and normal portions before laser therapy,
The corresponding any region R1 and corresponding any region R2 of normal portions of lesions position is selected in blood-stream image, calculates the lesion
Blood flow velocity the mean value V1 and V2 of area R1 and normal portions region R2, then first is calculated by formula (V1-V2)/V2
Blood flow changing value.
After treatment: blood-stream image is converted by the basic speckle image of lesions position and normal portions after laser therapy,
The corresponding any region R3 and corresponding any region R4 of normal portions of lesions position is selected in blood-stream image, calculates the lesion
Blood flow velocity the mean value V3 and V4 of area R1 and normal portions region R2, then second is calculated by formula (V3-V4)/V4
Blood flow changing value.In the present embodiment before and after treatment, focal area and normal region are all same positions, i.e. R2 be R4, R1 R3,
So the R1 still calculated after laser therapy is corresponding with R2 to cross blood flow velocity mean value.But it is noted that before and after treatment, focal zone
Domain and normal region also may not be same position, and the present embodiment is one of situation, without being limited thereto.
Specifically, the blood flow velocity detection method of the present embodiment specifically comprises the following steps:
1) select the semiconductor laser of 785nm as speckle laser light source 1,20 ° of laser beam expanding, speckle laser synchronization shines
Penetrate without laser therapy method lesion tissue and normal tissue, choose lesion R1 and normal region R2 (such as Fig. 3) before treating, photoelectricity at
As component 2 obtains blood-stream image through basic speckle image；
2) use 3 analyzed area R1, R2 of data analysis module speckle image, obtain corresponding blood flow velocity mean value V1,
V2 calculates lining ratio K (x, y) using formula (1), whereinIt is that pixel at (x, y) exists for collected image coordinate
Strength mean value on spatial neighborhood or time neighborhood, then σ (x, y) is the intensity variance value in same vicinity；Using formula (2) and
(3) it carries out that the flow speed value V (x, y) that coordinate is the pixel at (x, y) is calculated, wherein c is correction relevant to measuring device
Constant；
V (x, y)=c/ τc(3)；
V1=522, V2=162, (V1-V2)/V2=2.2 before calculating treatment；
3) by treatment 4 irradiated lesion region of laser light source, laser therapy uses the pulse laser of 585nm, 0.5ms pulsewidth
Irradiation treatment；
4) semiconductor laser of reselection 785nm is as speckle laser light source 1 after irradiating, and 20 ° of laser beam expanding, irradiation passes through
Laser therapy method lesion tissue and normal tissue are crossed, focal area R1, normal region R2 (such as Fig. 4), through basic speckle pattern are selected
As obtaining blood-stream image, the corresponding flow velocity mean value V3=247 of R1 after irradiating is calculated using the formula in step 2), R2 pairs after treatment
Flow velocity the mean value V4=470, (V3-V4)/V4=-0.47 answered.
It is repeated several times and blood flow velocity detection is carried out for focal area and normal region, pass through the variation of blood flow velocity mean value
Judge the recovery situation of focal area.The value of (V1-V2)/V2 is bigger before treatment illustrates that hyperemia is more serious at keloid lesion,
It is big that scar continues hyperplasia possibility；The value of (V3-V4)/V4 is smaller after treatment illustrates that therapeutic effect is more significant, and keloid is degenerated
Possibility is big.
Be it is necessary to described herein finally: above embodiments are served only for making technical solution of the present invention further detailed
Ground explanation, should not be understood as limiting the scope of the invention, those skilled in the art's above content according to the present invention
The some nonessential modifications and adaptations made all belong to the scope of protection of the present invention.
Claims (10)
1. a kind of laser speckle blood flow velocity change detecting method, it is characterised in that: the detection method uses laser speckle blood
Flow imaging technology obtains the blood flow velocity mean value in lesions position region and normal portions region before laser therapy, by laser respectively
The difference of the lesions position region and normal portions region blood flow velocity mean value Hemodynamic environment with the normal portions region again before treating
Degree mean value is compared, and the first blood flow changing value before laser therapy is obtained；Respectively obtain laser therapy after lesions position region and
The blood flow velocity mean value in normal portions region, by lesions position region after laser therapy and normal portions region blood flow velocity mean value
Difference again compared with the blood flow velocity mean value in the normal portions region, obtain the second blood flow changing value after laser therapy.
2. laser speckle blood flow velocity change detecting method according to claim 1, which is characterized in that the laser therapy
It include: pulsed dye laser, dot matrix CO2 laser or the Er:YAG laser irradiation lesions position using 585nm/595nm.
3. described in any item laser speckle blood flow velocity change detecting methods according to claim 1~2, which is characterized in that institute
Detection method is stated to specifically comprise the following steps:
A) the lesions position region in the synchronous irradiation normal portions region and untreated of speckle laser light source, obtains basic speckle pattern
Picture, and blood-stream image is obtained using basis speckle image described in laser speckle blood current imaging technical treatment；
B) in the blood-stream image that step a) is obtained, select the corresponding any region R1 of lesions position and normal portions corresponding
Any region R2, respectively analysis obtain the blood flow velocity mean value in the blood flow velocity mean value V1 and region R2 in the R1 of region
V2；
C) laser therapy carried out to lesions position, blood-stream image after being treated in a manner of step a) after treatment, then from institute
Any lesions position region R3 and any normal portions region R4 are selected in blood-stream image after stating treatment, analysis obtains area respectively
The blood flow velocity mean value V4 in blood flow velocity mean value V3 and region R4 in the R3 of domain；
D) according to formula (V1-V2)/V2, lesions position changes with respect to the first blood flow of normal portions before laser therapy is calculated
Lesions position is calculated after laser therapy with respect to the second blood flow changing value of normal portions according to formula (V3-V4)/V4 in value.
4. laser speckle blood flow velocity change detecting method according to claim 3, it is characterised in that: described V1, V2, V3
The mean value of all pixels point flow speed value in its one-to-one region is expressed as with V4.
5. a kind of device using such as the described in any item laser speckle blood flow velocity change detecting methods of Claims 1 to 4,
It being characterized in that, described device includes speckle laser light source, photoelectronic imaging component, data analysis module and treats laser light source,
In, speckle laser light source is used for irradiated lesion position and normal portions；Photoelectronic imaging collect components are radiated at lesions position and just
The laser at normal position collects basis of formation speckle image；Basic speckle image through data analysis module using laser speckle blood flow at
As the blood flow velocity mean value in lesions position region and normal portions region before acquisition laser therapy after technology analysis, calculating is swashed
The first blood flow changing value before light treatment；It treats laser light source and is used for irradiation treatment lesions position, pass through speckle laser after treatment
Light source irradiates lesions position and normal portions through treating, analyzes mould by data after the speckle image of photoelectronic imaging collect components basis
Block analysis obtains the blood flow velocity mean value in lesions position region and normal portions region again, second after obtaining laser therapy
Blood flow changing value.
6. device according to claim 5, which is characterized in that the speckle laser light source is semiconductor laser；It is described
Treating laser light source includes the pulsed dye laser of 585nm/595nm, dot matrix CO2 laser or Er:YAG laser.
7. device according to claim 5, which is characterized in that data analysis module is specifically used for: will be before and after laser therapy
The basic speckle image of lesions position and normal portions is converted into blood-stream image, selects lesions position corresponding in blood-stream image
Any region and the corresponding any region of normal portions, calculate the blood flow velocity in the lesions position region and the normal portions region
Mean value, further according to blood flow velocity mean value computation blood flow changing value.
8. device according to claim 5, which is characterized in that the photoelectronic imaging component is that analog-to-digital conversion is not less than 12
Camera or video camera.
9. a kind of detection system for keloid, which is characterized in that the system comprises any one of such as claims 5~8
The device.
10. the detection system according to claim 9 for keloid, which is characterized in that described device is respectively to controlling
The blood flow changing value of keloid before treating and after treatment is detected.
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