CN109661237A - It is set as the skin irritatin as caused by micronic dust and scytitis alleviation of effective component with composition comprising holy basil, peppermint, margosa tree tree extraction mixture - Google Patents
It is set as the skin irritatin as caused by micronic dust and scytitis alleviation of effective component with composition comprising holy basil, peppermint, margosa tree tree extraction mixture Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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Abstract
The present invention relates to the scytitis alleviation Dermatologic preparation compositions comprising natural extraction mixture as effective component.According to the present invention, Dermatologic preparation composition comprising holy basil, peppermint, margosa tree tree extraction mixture as effective component, alleviate the skin irritatin as caused by micronic dust and scytitis by the expression of inhibition inflammation-induced cell factor (IL-6, IL-8) caused by micronic dust, to finally can be effectively applied to the purposes of skin allergy prevention and improvement, flushing improvement, dermatitis prevention and improvement etc..
Description
Technical field
The present invention relates to comprising alleviating active natural mixture as effective with skin irritatin alleviation and scytitis
The Dermatologic preparation composition of ingredient, more particularly, to the extraction mixture comprising holy basil, peppermint, margosa tree tree
Dermatologic preparation composition is used in skin irritatin alleviation and scytitis alleviation.
Background technique
One of most important function of skin is the defencive function as barrier.It is anti-for being directly exposed to the skin of external environment
Only loss of body fluids, and from hostile environment protect body most important first defence line.Also, for toxicant or micro- life
Object, physical stimulation or ultraviolet light execute barrier function.But if this skin barrier function by skin outside, it is internal a variety of
Stimulation, then skin barrier is impaired, causes skin to become drying, or skin is made to cause inflammatory reaction.Moreover, if can not effectively control
The Preliminary Irritation reaction occurred at this time, it is likely that deteriorate as serious dermatitis.
But as population growth, urbanization, industrialization and automobile increase etc. influence, atmosphere pollution exacerbation is dirty as a result,
The type of dye substance becomes multiplicity.In particular, being faced with due to the positional factor of South Korea from the Air Pollutants of China's discharge
The aggrieved of caused yellow sand and micronic dust etc. is moved, seriousness is also got higher.Micronic dust (particulate matter) is according to particle
Size be divided into that diameter is 10 μm of micronic dusts (PM10) below and diameter is 2.5 μm of ultra micro dirt (PM2.5) below.South Korea's environment
PM10 is limited to Air Pollutants by portion.It is well known that the Air Pollutants Induced respiration tract disease such as this micronic dust and the heart
Dirty disease, meanwhile, area shared in body wider skin bring influence is also more and more paid close attention to.In particular, according to
It reports, it is impaired that the micronic dust in Air Pollutants makes epidermal barrier function, and deteriorates allergic dermatitis.Also, with it is common
Skin is compared, and sensitive generates more sensitive reaction for external stimulation or environmental change, so that stimulation or skin be presented
Skin inflammation shape.It was found that being compared with normal people, the people with this sensitive feels that the degree of stimulation is quicker to micronic dust
Sense, can feel 3 times or more of excitement.Therefore, the polluter of micronic dust etc. especially generates skin to the people with sensitive
A possibility that skin problem, is high.It has an effect on skin aging, according to nearest epidemiological study, is exposed to and occurs on the skin of micronic dust
Wrinkle and color spot increase, directly related to aging.Micronic dust produces active oxygen to inhibit collagen synthesis, and can activate decomposition,
The polycyclic aromatic hydrocarbon (PAH, polycyclic aromatic hydrocarbon) for being adsorbed in micronic dust surface activates biology by AhR
Body foreign body metabolism decomposes to increase collagen, so that skin aging occur.It should grope to reduce the direct of micronic dust and skin as a result,
The method of contact and new cure by molecular mechanism correlative study.
Inflammatory reaction (inflammatory response) in skin is arised from because of physical stimulation or chemical substance, bacterium
Deng and for defending its effect when causing skin damage, panimmunity cell and inflammation-induced cell factor are participated.It is white
Cytokine -6 (IL-6, interleukin-6), interleukin 8 (IL-8, interleukin-8), interleukin-1 ' beta '
(IL-1 β, interleukin- β) etc. is representative inflammation-induced cell factor.IL-1 β is thin by the mononuclear phagocyte activated
Born of the same parents, epithelial cell, vascular endothelial cell are formed and the typical cell factor of inducing inflammatory reaction, IL-6 be by T cell and
Macrophage and secreted, immune response stimulating, and adjust the cell factor of inflammatory reaction.Also, the macrophage of activation
(macrophage) not only generate inflammation-induced cell factor, but also excessively generate nitric oxide (NO, nitric oxide) or
Prostaglandin (prostagladin) E2 (PGE2), to more activate inflammatory process.It was reported that the micronic dust of promotion and anti-inflammatory
Particle increases the expression of this inflammation-induced cell factor in human keratinous formation cell.
In the past, the cosmetics of anti-inflammatory properties can be assigned using natural extract to skin by attempting exploitation in many ways,
Its typical case is as follows: the cosmetic combinations comprising Flos Camelliae Japonicae extract are proposed in KR published patent the 2007-0011939th
Object is proposed calm comprising mung bean fermentation-zyme extract skin and is stimulated in KR published patent the 2010-0086698th
Alleviate the composition that applies some make up, refers in KR published patent the 2013-0016930th comprising Salvia japonica, balm, parmelia saxatilis
Dish and Bulbus Allii Cepae extract apply some make up composition as the allergic skin of effective component and skin irritatin alleviation.Also, in Korea Spro
Itd is proposed in state's publication the 2015-0078948th comprising mistletoe, pine bark and watt lotus flower mixed extract as effectively at
The scytitis divided improves or the composition that applies some make up is alleviated in skin irritatin, in KR published patent the 2009-0091547th
It is proposed that the composition that applies some make up is alleviated in the anti-inflammatory and skin irritatin of the mixed extract comprising Eclipta prostrata and frutus cnidii.On but
State in cosmetic composition it is any all do not imply or enlighten mentioned using the specific combination of natural goods as described in the present invention
Object is taken effectively to inhibit in a manner of synergistic effect (synergy) generation of inflammation-induced cell factor, to have skin thorn
Swash the cosmetic composition of alleviation and scytitis remission effect.
In this regard, the present inventor makes great efforts the result studied to overcome above-mentioned problem of the prior art, it is appreciated that because a variety of
Stimulation, especially increased inflammatory cytokine is related to skin irritatin and scytitis due to micronic dust stimulates, and improves to excavate
The substance of this problem screens the plant extracts for inhibiting the expression of inflammatory cytokine to be compared, wherein is inciting somebody to action
In the case that holy basil, peppermint and margosa tree tree are mixed, confirming it has by inhibiting as inflammation-induced cell
The expression of IL-6, IL-8 of the factor are come the effect of alleviating skin irritatin and scytitis, so as to complete the present invention.
Summary of the invention
Technical problem
The present inventor is directed to the extensive extract that obtains from a variety of natural goods and combinations thereof, and to have investigated inflammation-induced thin
The activity suppression degree of intracellular cytokine, as a result, significant cumulative bad synergy is presented in the combination for confirming specific natural goods
The fact is based on this, inhibits IL-6 and the IL-8 expression as inflammation-induced cell factor increased because of micronic dust stimulation, to mention
For having effects that alleviate the scytitis alleviation Dermatologic preparation composition of skin irritatin and scytitis.
Therefore, it is a primary object of the present invention to provide following Dermatologic preparation composition, using according to natural goods
The composite extract of specific combination inhibits the generation of inflammation-induced cell factor in a manner of synergistic effect (synergy), thus
With skin irritatin alleviation and scytitis remission effect.
It is a second object of the invention to provide following cosmetic composition, application is other function cosmetics group
The basic formulation of object is closed to assign skin irritatin alleviation and scytitis remission effect, to can realize skin allergy prevention and change
Kind, flushing improvement, dermatitis prevention and improvement.
Technical solution
According to the preferred embodiment of the present invention for smoothly realizing the purpose of aforementioned present invention, provide comprising holy sieve
Skin irritatin alleviation and the dermatitis as caused by micronic dust of Le, peppermint and the mixed extract of margosa tree tree as effective component
Disease, which alleviates, uses Dermatologic preparation composition.
Holy basil (Ocimum sanctum) is the annual grass for belonging to Lamiales Labiatae.As Tropical Asia India and
Asia originates in, and is mainly grown in Pacific Ocean island, and height is 40m or so.The fragrance of sweet basil, which has, can make brains clear and removal
The drug effect of headache not only contributes to oversensitive, headache, and also effective to stomatitis, also if drinking as tea
Conducive to promotion appetite and digestion.The movement of brains is enlivened, and improves headache syndromes.Moreover, it is well known that have and mentioned comprising sweet basil
The skin moisturization (Korean granted patent 10-1599256) of the cosmetic composition of object, oxidized protein is taken to decompose enzymatic activity
Reinforcing effect (KR published patent 2015-0119336) etc..
Peppermint (Mentha haplocalyx) is the perennial root grass of tubular flower mesh Labiatae.Summer to autumn, in stem
Upside axil, relatively thin purple little Hua is open with the shape of fringe.Its effect is used in exogenous disease sexuality and emits caused fever, head
Bitterly, the symptom that do not perspire is used in the hyperemia of eyes, sphagitis, tonsillitis, morbilli primary skin are itched disease, hepatopathy, abdomen
Bitterly, diarrhea, vomiting etc..It was reported that pharmacological action have heat-clearing, anti-inflammatory, stomach invigorating, bile secretion promote and stomach smooth muscle inhibit,
The mucous secretion increase of respiratory tract, central nervous excitation, uterine contraction etc..The main component of peppermint oil is menthol, the peppermint
Alcohol is used for coating agent, analgesic, excitant, peptic, pest repellant etc. in medicinal mode, or in a manner of freshener or fragrance
For toothpaste, jam, candy, cosmetics, cigarette etc..Moreover, it is well known that have the cosmetic composition comprising mint extract
Pore shrink and sebum secretion inhibitory effect (KR published patent 2013-0016929) and include mountain mint extract conduct
Whitening effect (KR published patent 2009-0018459) of the cosmetic composition of effective component etc..
Margosa tree tree (Azadirachta indica) is grown in subtropical zone as half aiphyllium for belonging to Meliaceae more
And torrid areas is used as food, pharmaceuticals and insecticide as the spontaneous tree in India and periphery state, it is reported that, ingredient is lemon
Lemon hardship chlorins compound (limonoids), nimbin (Azadirachtin), print chinaberry Sha Lanlin (salannin), chinaberry three
The triterpenes (triterpenes) of alcohol (meliantriol) and print chinaberry guest (nimbin) etc..The type similar as its, South Korea
There are chinaberry, also referred to as China tree wood.After sloughing stem and drying, it is referred to as azedarach, after fruit is dried, referred to as chinaberry or river
Chinaberry FRUCTUS TOOSENDAN, for treating helminth, abdominal pain scabies, malignant sore.Moreover, it is well known that have and mentioned comprising margosa tree tree fruit
The acne of the cosmetic composition of object is taken to prevent effect (KR published patent 2003-0017295) etc..
It is a feature of the present invention that in above-mentioned mixed extract, holy basil: peppermint: the content of margosa tree tree with 1~
The weight ratio of 6:1~6:1~6 is mixed.
Above-mentioned holy basil, peppermint contained in composition of the invention, margosa tree tree extraction mixture be by 25~
The print of the herb of the peppermint of the herb of the holy basil of 50 weight percent, 25~50 weight percent, 25~50 weight percent
The form for spending the composite extract of the mixture of the leaf composition of margosa can be by above-mentioned holy basil, peppermint, margosa tree tree
The mixed extract therefrom obtained after mixing.
Above-mentioned holy basil, peppermint and margosa tree tree, the material fragmentation for being dried in the shade or being air-dried are used, it is preferable that be
Raising extraction effect uses after carrying out seperatedization in a manner of broken.
Also, in the present invention, as described above, 3 kinds of raw materials are mixed together to carry out solvent extraction, although this is in process
It is preferred in terms of efficiency, but according to circumstances, with identical solvent, quantity of solvent and item is extracted respectively for these 3 kinds of raw materials
After part obtains extracting solution, it can be mixed in a manner of equivalent or be made with the ratio mixing of weight percent as described above
With, said extracted liquid can also for concentrate form or freeze-drying and fissionization form.
In order to obtain as effective component be included in Dermatologic preparation composition of the invention said extracted mixture and
Workable Extraction solvent can be extracted using any solvent used in the past, it is preferable that using selected from comprising water,
Lower alcohol, butanediol, propylene glycol, one of the solvent group of glycerol pure solvent or the two or more combinations that carbon number is 1 to 4 it is mixed
Bonding solvent, but this is unrestricted in the present invention.The additive amount of Extraction solvent, relative to the total volume of mixed raw material, preferably 1
To 20 times of volume.
Using the extracting method of said extracted solvent, the extracting method of conventional plant can be used, for example, hot water extraction,
Flow back the methods of cooling extractions, ultrasonic wave extraction, means of supercritical extraction, specifically, the herb of broken holy basil, the herb of peppermint and
The leaf of margosa tree tree prepares powder, and is impregnated in Extraction solvent as described above, and room temperature is extracted 24 to 72 hours.It connects
, the extraction filtrate of acquisition is filtered, is dried under reduced pressure, obtains concentration mixed extract, or be freeze-dried and
Obtain powder.
It is a feature of the present invention that the total weight relative to Dermatologic preparation composition, includes 0.001 to 30 weight percent
The above-mentioned mixed extract of ratio.If mixed extract is less than 0.001 weight percent, there are scytitis remission effect is little
Worry, it is thus not preferred, on the contrary, if mixed extract be greater than 30 weight percent, it is likely that it is unexcellent on economic aspect
Choosing.
Experimental example according to the present invention, confirms the inhibitory effect of the increased inflammatory cytokine because of micronic dust, as a result,
In the case where holy basil of the invention, peppermint and margosa tree tree mixed extract, outstanding inhibitory effect is presented, in particular,
When compared to independent processing, it is more outstanding to confirm scytitis inhibitory effect.According to this as a result, mixing of the invention
Extract can alleviate the scytitis as caused by micronic dust by inhibiting inflammation inducing cytokine.
Also, confirm the epidermis as caused by micronic dust stimulation remission effect the results show that just mixing of the invention
For extract, the epidermis and epidermal cell being damaged by micronic dust stimulation are restored.According to this as a result, holy sieve
The epidermis that Le, peppermint and margosa tree tree mixed extract also can be relieved stimulation caused by reason micronic dust and occur is impaired, i.e.,
The skin irritatin as caused by micronic dust.
It is a feature of the present invention that above-mentioned Dermatologic preparation composition can be used as can be applied to the pharmaceutical compositions of skin
Or cosmetic composition, for cosmetic composition, for selected from by soft toner, nutrition toner, nutrition essence, battalion
Support one in the group of oil, moisturizing oil, nourishing cream, muffin, facial mask, foundation cream, sun screen, mildy wash, gel, lotion and ointment composition
Kind or more dosage form.
As effective component, other than above-mentioned mixed extract, ingredient contained in cosmetic composition of the invention
It may include the Multiple components for being usually used in cosmetic composition, for example, including stabilizer, solubilizer, vitamin, pigment and perfume (or spice)
The conventional auxiliary agent and carrier of material etc.
Pharmaceutical compositions of the invention can with frost, gel, diaphragm, spray, ointment, emplastrum, emulsion agent, liniment,
Any dosage form well known in the art such as paste or opoultice carries out dosage form.
Also, the preferred dosage of above-mentioned pharmaceutical compositions, according to the state of patient and weight, disease degree, drug shape
State, administration route and period and difference, but can be properly selected by general technical staff of the technical field of the invention.But
It is, for preferred effect, administration 0.0001 to 100mg/kg in composition 1 day of the invention, it is preferable that administration 0.001 to 10mg/
kg.Topical administration can be administered once a day, can also be divided into multiple dosing.
Also, the present invention is provided to prepare include holy basil, peppermint and margosa tree tree mixed extract by micro-
Skin irritatin caused by dirt and scytitis alleviate the purposes for using Dermatologic preparation composition.
Also, the present invention provides the skin irritatin as caused by micronic dust and scytitis treatment method comprising by acology
The mixed extract of a effective amount of holy basil, peppermint and margosa tree tree is applied to the step of skin of object.
In the present invention, above-mentioned " object " can be include the mammal of the mankind, but be not limited to these examples.
The effect of invention
As described above, a variety of stimulations can be effectively suppressed in holy basil of the invention, peppermint, margosa tree tree mixed extract,
Skin irritatin and skin are alleviated in the expression of the inflammation-induced cell factor (IL-6, IL-8, IL-1 β) especially overexpressed by micronic dust
Skin inflammation.
Detailed description of the invention
Fig. 1 is the result for indicating to present the experimental example 1 of IL-6 gene expression inhibition degree in inflammation-induced cell factor
Figure.
Fig. 2 is the result for indicating to present the experimental example 1 of IL-8 gene expression inhibition degree in inflammation-induced cell factor
Figure.
Fig. 3 is the photograph that the measurement result that the epidermis impaired because of micronic dust is restored when handling mixed extract is presented
The figure of piece.
Specific embodiment
Hereinafter, by embodiment, the present invention will be described in more detail.These embodiments are only used for illustrating the present invention, because
Without being interpreted that the scope of the present invention is confined to these embodiments.
Embodiment 1: holy basil, peppermint and margosa tree tree extraction mixture preparation
By after the air-dried herb of holy basil, the herb of peppermint, margosa tree leaf difference powdered, take respectively
33.3g mixes total 99.9g as Extraction solvent and impregnates 1L in the ethanol water of 70 weight percent, and at room temperature
It places 24 hours, to obtain extracting solution.After filtering extracting solution obtained using filter paper, rotary evaporation drying is utilized
Filtrate is concentrated under reduced pressure in machine, to obtain concentration extraction mixture.
Comparative example 1: the preparation of holy basil, peppermint and the independent extract of margosa tree tree
As a comparison, individual raw material powders of the herb of holy basil, the herb of peppermint and margosa tree leaf are taken respectively
100g, and be respectively put into individual container, as Extraction solvent, it is impregnated in the ethanol water (1L) of 70 weight percent
In, it places 24 hours at room temperature, to obtain extracting solution.
After filtering extracting solution obtained using filter paper, filtrate is depressurized using rotary evaporation drying machine
Concentration, to obtain each concentrated extract.
Experimental example 1: the evaluation of anti-inflammatory effect
In order to evaluate the anti-inflammatory effect of mixed extract, to IL-6 and the IL-8 processing as inflammation-induced cell factor
Micronic dust (PM10), and determine its expression quantity.In more detail, micronic dust is handled to the HaCaT cell as keratinocyte, with
Equal weight proportions make each holy basil prepared in comparative example 1, peppermint, the independent extract of margosa tree tree and in embodiment 1
The ultimate density of the extraction mixture of middle acquisition reaches 10 μ g/ml, and is diluted in culture medium, thus cultivates 4 hours.Then,
In the cell, mRNA is extracted, is synthesized with cDNA, and implements real-time (real-time) using target template (primer) and gathers
Polymerase chain reacts (PCR), the final degree of gene expression for evaluating inflammatory cytokine.It the results are shown in Fig. 1 and Fig. 2.
As a result, as depicted in figs. 1 and 2, evaluable independent extract when inducing each cell factor because of micronic dust and
The inhibition level of mixed extract, mixed extract are presented highest to all cell factors and significantly induce in synergistic effect
Inhibitory effect.Therefore, confirming mixed extract of the invention is to antiphlogistic effects more higher than independent extract
The highly useful raw material of cosmetic composition.
Experimental example 2: the evaluation of epidermis stimulation remission effect
In order to evaluate skin epidermis stimulation remission effect, had rated using the artificial skin tissue of 3 dimension cultures because of micronic dust
And it stimulates, the remission effect of impaired epidermis.Firstly, the micronic dust (PM10) of 50 μ g/ml is coated on artificial skin surface, and
With the concentration of 10 μ g/ml by the mixed extract obtained in embodiment 1 processing on culture medium.Additional cultivation 24 hours it
Afterwards, it is fixed on after formalin, prepares paraffin mass (paraffin block) Lai Jinhang H&E dyeing.Thus epidermis is determined
The cuticula of layer and the form of keratinocyte.Also, it is measurement result is shown in Figure 3.
As a result, as shown in figure 3, the cuticula for confirming the artificial skin tissue being damaged by micronic dust processing is delayed
Solution.Also, it can confirm that the density of the keratinocyte of base and shape are restored.Therefore, it can confirm mixing of the invention
Extract is to the highly useful raw material of cosmetic composition with the stimulation alleviation of the epidermis impaired because of stimulation.
Dosage form example 1: the preparation of toner
According to constituent shown in following table 1 and ratio of components, it is prepared for by conventional method comprising above-described embodiment 1
The toner of the extraction mixture of middle acquisition.
Table 1
Dosage form example 2: the preparation of nutrition essence
According to constituent shown in following table 2 and ratio of components, it is prepared for by conventional method comprising in embodiment 1
The nutrition essence of the extraction mixture of acquisition.
Table 2
Dosage form example 3: moisturiser
According to constituent shown in following table 3 and ratio of components, it is prepared for by conventional method comprising in embodiment 1
The moisturiser of the extraction mixture of acquisition.
Table 3
Industrial applicibility
As described above, according to the present invention, including holy basil of the invention, peppermint, margosa tree tree extraction mixture conduct
The cosmetic composition of effective component alleviates skin thorn by inhibiting the expression of inflammation-induced cell factor (IL-6, IL-8)
Swash and scytitis alleviate, thus finally can be effectively applied to skin allergy prevention and improve, it is flushing improve, dermatitis prevention and
The purposes of improvement etc..
Bibliography
(patent document 0001) Korean Patent Publication No.2007-0011939
(patent document 0002) Korean Patent Publication No.2010-0086698
(patent document 0003) Korean Patent Publication No.2013-0016930
(patent document 0004) Korean Patent Publication No.2015-0078948
(patent document 0005) Korean Patent Publication No.2009-0091547
Claims (8)
1. a kind of skin irritatin as caused by micronic dust and scytitis alleviation Dermatologic preparation composition, which is characterized in that packet
Mixed extract containing holy basil, peppermint and margosa tree tree is as effective component.
2. skin irritatin according to claim 1 and scytitis, which are alleviated, uses Dermatologic preparation composition, which is characterized in that
In the mixed extract, holy basil: peppermint: the content of margosa tree tree is mixed with 1~6:1~6:1~6 weight ratio
It closes.
3. skin irritatin according to claim 1 and scytitis, which are alleviated, uses Dermatologic preparation composition, which is characterized in that
The mixed extract using water, carbon number be 1 to 4 lower alcohol, butanediol, propylene glycol, glycerol or their mixed solvent come
It extracts.
4. skin irritatin according to claim 1 and scytitis, which are alleviated, uses Dermatologic preparation composition, which is characterized in that
Relative to the total weight of composition, the mixed extract comprising 0.001 to 30 weight percent.
5. skin irritatin according to claim 1 and scytitis, which are alleviated, uses Dermatologic preparation composition, which is characterized in that
The mixed extract alleviates scytitis by inhibiting the expression of the inflammatory cytokine caused by micronic dust.
6. skin irritatin according to claim 1 and scytitis, which are alleviated, uses Dermatologic preparation composition, which is characterized in that
The composition is selected from by soft toner, nutrition toner, nutrition essence, nutritional oil, moisturizing oil, nourishing cream, muffin, face
The State of cosmetics of one or more of the group that film, foundation cream, sun screen, mildy wash, gel, lotion and ointment form.
7. a kind of purposes for being used to prepare the skin irritatin as caused by micronic dust and scytitis alleviation Dermatologic preparation composition,
It is characterized in that, the skin irritatin as caused by micronic dust and scytitis alleviation Dermatologic preparation composition include holy sieve
It strangles, the mixed extract of peppermint and margosa tree tree.
8. a kind of skin irritatin as caused by micronic dust and scytitis treatment method, which is characterized in that acology is a effective amount of
The mixed extract of holy basil, peppermint and margosa tree tree is applied to the skin of object.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020160097095A KR101873218B1 (en) | 2016-07-29 | 2016-07-29 | Composition for alleviating skin irritation and skin inflammation induced by particulate matter comprising extracts mixture of Ocimum sanctum, Mentha haplocalyx, and Azadirachta indica |
| KR10-2016-0097095 | 2016-07-29 | ||
| PCT/KR2017/007948 WO2018021777A1 (en) | 2016-07-29 | 2017-07-24 | Composition for alleviating skin irritation and skin inflammation caused by fine dust, containing, as active ingredient, mixture of holy basil, mentha canadensis, and azadirachta indica extracts |
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| Publication Number | Publication Date |
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| CN109661237A true CN109661237A (en) | 2019-04-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201780046691.0A Pending CN109661237A (en) | 2016-07-29 | 2017-07-24 | It is set as the skin irritatin as caused by micronic dust and scytitis alleviation of effective component with composition comprising holy basil, peppermint, margosa tree tree extraction mixture |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR101873218B1 (en) |
| CN (1) | CN109661237A (en) |
| WO (1) | WO2018021777A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113350232A (en) * | 2020-03-05 | 2021-09-07 | 株式会社现代百朗德 | Cosmetic composition for skin protection and irritation relief containing mixed extract of purslane, mugwort leaf and rhodiola rosea as active ingredient |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101988489B1 (en) | 2018-06-04 | 2019-06-12 | 주식회사 익스플즌 | Functional cosmetic composition for anti-dust and anti-inflamatory containing natural extract as an effective ingredient and functional cosmetic including the same |
| KR20200096360A (en) | 2019-02-01 | 2020-08-12 | 주식회사 티젠 농업회사법인 | Composition comprising Holybasil and Lemon balm extracts for Stress Relaxation |
| KR102207389B1 (en) | 2019-02-20 | 2021-01-26 | (주)허니스트 | Cosmetic Composition for Anti-fine dust Containing Actinidia arguta Extract |
| KR20210065546A (en) | 2019-11-27 | 2021-06-04 | (주)아모레퍼시픽 | Composition comprising pyruvate for preventing damage of skin cell by microdust |
| KR102392334B1 (en) * | 2019-11-29 | 2022-05-02 | 대구한의대학교산학협력단 | Cosmetic composition for enhancing skin barrier comprising basil oil |
| KR102471312B1 (en) * | 2020-05-19 | 2022-11-28 | (주)허니스트 | Cosmetic composition that protects skin from fine dust, including Nim Tree leaf extract |
| KR102586050B1 (en) * | 2021-07-14 | 2023-10-05 | 동의대학교 산학협력단 | Composition for skin anti-pollution containing banana peel extract as an active ingredient |
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| JP4562466B2 (en) * | 2004-09-09 | 2010-10-13 | 一丸ファルコス株式会社 | Neem extract production method and hypoallergenic cosmetic composition containing the same |
| KR20110037462A (en) * | 2009-10-07 | 2011-04-13 | (주)더페이스샵 | Cosmetic composition containing neem extract for alleviating skin inflammation |
| AU2010330812B2 (en) * | 2009-12-18 | 2016-03-10 | Exodos Life Sciences Limited Partnership | Methods and compositions for treating inflammation of skin |
| KR101477959B1 (en) * | 2014-07-28 | 2015-01-06 | 바이오스펙트럼 주식회사 | Anti-irritating cosmetic compositions for skin comprising extracts of Aloe Aborescens |
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2016
- 2016-07-29 KR KR1020160097095A patent/KR101873218B1/en active IP Right Grant
-
2017
- 2017-07-24 WO PCT/KR2017/007948 patent/WO2018021777A1/en active Application Filing
- 2017-07-24 CN CN201780046691.0A patent/CN109661237A/en active Pending
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| GOVIND PANDEY: "Pharmacological activities of ocimum sanctum(TULSI):A review", 《INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCE REVIEW AND RESEARCH》 * |
| SHAZIA ASTRAF: "Khadi Neem Basil and Mint Face Pack Review", 《MAKEUPANDBEAUTY(HTTPS://MAKEUPANDBEAUTY.COM)》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113350232A (en) * | 2020-03-05 | 2021-09-07 | 株式会社现代百朗德 | Cosmetic composition for skin protection and irritation relief containing mixed extract of purslane, mugwort leaf and rhodiola rosea as active ingredient |
| CN113350232B (en) * | 2020-03-05 | 2023-07-21 | 株式会社现代百朗德 | Cosmetic composition for protecting skin and relieving irritation containing mixed extract of herba Portulacae, folium Artemisiae Argyi and radix Rhodiolae as effective components |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180014356A (en) | 2018-02-08 |
| WO2018021777A1 (en) | 2018-02-01 |
| KR101873218B1 (en) | 2018-07-03 |
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