CN109646463A - A kind of Cordyceps militaris capsules and preparation method thereof - Google Patents

A kind of Cordyceps militaris capsules and preparation method thereof Download PDF

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CN109646463A
CN109646463A CN201810722135.7A CN201810722135A CN109646463A CN 109646463 A CN109646463 A CN 109646463A CN 201810722135 A CN201810722135 A CN 201810722135A CN 109646463 A CN109646463 A CN 109646463A
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cordyceps
cordyceps militaris
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陈伟翰
黄伟静
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Jilin Zhongsheng Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

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Abstract

The present invention provides a kind of Cordyceps militaris capsules and preparation method thereof.Cordyceps militaris capsules provided by the invention are Chinese caterpillar fungus preparation (i.e. cordyceps sinensis substrate and cordyceps species are as capsule 's content), the Chinese caterpillar fungus preparation using cordycepin content as detection project in quality standard for selecting the Cordyceps militaris for having patent Cultivating techniques as raw material, in the form of natural cs.Cordyceps militaris capsules provided by the invention, it not only can guarantee that Cordyceps militaris effective component is not destroyed, the active constituent contents such as cordycepin, amino acid are high, and cordyceps dispersibility, dissolubility and absorbability be improved significantly, capsule convenient for taking and carrying, supplementary product consumption is few, preparation method is simple to operation.

Description

A kind of Cordyceps militaris capsules and preparation method thereof
Technical field
The invention belongs to field of pharmaceutical preparations, and in particular to one kind can guarantee that Cordyceps militaris effective component is not destroyed, effectively Component content is high, dispersibility, dissolubility and absorbability be improved significantly, convenient for taking and carrying, supplementary product consumption is few, preparation side Method method Cordyceps militaris capsules simple to operation and prepare said preparation.
Background technique
Cordyceps militaris [Cordyceps militaris (L.) Link] is also known as Cordceps militaris, northern Chinese caterpillar Fungus, pupa grass, is subordinate to Belong to mycota Ascomycota (Ascomycota), Ascomycetes (Ascomycetes), excrement shell bacterium subclass (Sordariomycetidae), Hypocreales (Hypocreales), Clavicipitaceae (Clavicipitaceae), Cordyceps It (Cordyceps), is the type sepecies of Cordyceps sinensis fungus.Had found more than 400 kinds of Cordyceps sinensis fungus in the world to 2002, wherein China's report has 120 kinds or so, and Cordyceps militaris is distributed all over the world.
Cordyceps militaris is that food, the medicine of plurality of active ingredients close to cordyceps sinensis share fungi, is to have higher edible medicinal valence The entomogenous fungi complex of value, pharmacology, medicine and clinical trial prove that Cordyceps militaris can be used as the substitute of cordyceps sinensis completely.Winter Worm summer grass and ginseng, pilose antler are eponymous, for Chinese tradition three big tonics and have won fame both at home and abroad, Chinese medicine thinks, cordyceps sinensis enters lung kidney two warp, Kidney deficiency, impotence and seminal emission, soreness of waist and knee joint, eak after being ill, spontaneous sweating etc. are cured mainly, is that unique a kind of can balance simultaneously, adjust yin The Chinese medicine of sun.Therefore, the application study in relation to Cordyceps militaris also becomes the hot spot both at home and abroad in cordyceps sinensis research direction.
Cordyceps militaris also contains other than containing life basic elements such as protein, lipid, carbohydrate, vitamin, microelements The various bioactivators such as cordycepic acid, cordycepin, Cordyceps sinensis polysaccharide, superoxide dismutase (SOD).Cordycepic acid (mannitol) can To reduce cranium pressure significantly, promote body metabolism, thus cerebral hemorrhage and cerebral thrombosis disease is made to be eased.Cordycepin is one Kind has the nucleosides material of antibacterial activity, has very strong inhibiting effect to nuclear polyadenylic acid polymerase.In DNA transcript mRNA Make mRNA dysmaturity in the process, inhibit the growth of cancer cell, and plays the role of hypoglycemic.Cordyceps sinensis polysaccharide is a kind of highly branched Galactomannans, it can promote lymphocyte transformation, improve the antibody content of serum IgG and the immune function of body, increase The ability of strong body itself anticancer suppression cancer.SOD can eliminate superoxide radical in body, the work with anti-aging, anticancer suppression cancer With.In addition, Cordyceps militaris selenium (Se) also rich in, is the essential trace elements of the human body, is the work of glutathione peroxidase Property center, is connected on the peptide chain of zymoprotein in the form of selenocystein, protects the normal penetrating of the stability of cell membrane Property, and the generation of immunoglobulin and antibody is stimulated, enhance immunity of organism and oxidation resistance.Meanwhile a large amount of scientific practice Prove that selenium can significantly inhibit the growth of cancer cell.
No. 3 bulletin of the Ministry of Public Health 2009 have approved Cordyceps militaris be new resource food, it is specified that amount≤2 gram/day and It is edible to be not suitable for infant, children, edible fungus allergy sufferers.Country defends planning commission's No. 10 bulletin in 2014 and eliminates Cordyceps militaris Daily edible limitation, specifies only infant, children, edible fungus allergy sufferers inedibility, this is also beneficial to Cordyceps militaris product Research and development.
Use of the traditional approach to Cordyceps militaris takes decoction more, processes, steeps in wine, or take the stewing together with food Mode, Cordyceps militaris pass through high-temperature process, and loss of effective components is serious, activated protein therein and by thermally labile effective component, It is destroyed in the process, this makes Cordyceps militaris that conventional method processing be taken to use, and effective rate of utilization is very low.In addition, modern Research majority be directed to the extractions of Cordyceps sinensis polysaccharide, the followed by extraction of cordycepin, the extraction research of cordycepic acid and cordyceps sinensis SOD are not It is more.And the extraction process of each ingredient is different, and single method can only extract single substance, other nutriments then all by Give up and slattern, this is practically wasted Cordyceps militaris resource.
Due to the unique stink smell slight bitter taste of Cordyceps militaris, directly takes cordyceps powder and be then difficult to swallow, consumer compliance Difference is difficult to adhere to taking.Existing Cordyceps militaris piece, smell mouthfeel is not good enough, and some consumers are not easily accepted by, and stability is low, Influence the performance of effect；In addition a large amount of auxiliary materials are added, the content of Cordyceps militaris piece is significantly affected, and adenosine in production process, The decline of the effective components such as albumen is obvious, i.e. reduction validity of products, and increases dose.Cordyceps militaris alcohol product, although compared with It is easily made, but has limitation for the crowd that should not be drunk.That there is also stability is low for the products such as electuary, oral solution, influences effect Problem.Therefore it is good to need to find a kind of stability, active constituent content is high, the Cordyceps militaris that highly reliable and consumer is willing to accept Formulation products.
Summary of the invention
In view of the above technical defects, present invention solves the technical problem that being to provide a kind of Cordyceps militaris capsules and its system Preparation Method, Cordyceps militaris capsules obtained can guarantee that Cordyceps militaris effective component is not destroyed, and active constituent content is high, dispersion Property, dissolubility and absorbability be improved significantly, convenient for taking and carrying, supplementary product consumption is few, and preparation method is simple to operation.
Cordyceps militaris capsules provided by the invention select worm of the Cordyceps militaris as raw material for having patent Cultivating techniques Careless preparation, the Chinese caterpillar fungus preparation (i.e. cordyceps sinensis substrate and cordyceps species are as capsule 's content) in the form of natural cs, with cordyceps sinensis Chinese caterpillar fungus preparation of the cellulose content as detection project in quality standard.
The specific technical solution of the present invention is as follows:
The present invention provides a kind of Cordyceps militaris capsules, which is characterized in that the Cordyceps militaris capsules include cordyceps powder, Diluent, glidant.
The Cordyceps militaris capsules, which is characterized in that its composition is as follows:
Cordyceps militaris 100-300 mg
Diluent 20-200 mg
Glidant 5-50 mg
The Cordyceps militaris, which is characterized in that including cordyceps sinensis substrate and cordyceps species.
The diluent can be selected from starch, sucrose, lactose, mannitol, inulin, sorbierite, xylitol, maltodextrin One or both of mixture.
The glidant agent can be selected from the mixture of one or both of silica, talcum powder.
The Cordyceps militaris capsules preparation method the following steps are included: (1) Cordyceps militaris through dry and ultramicro grinding at Reason, obtains cordyceps powder；(2) cordyceps powder sterilizes, spare；(3) cordyceps powder, diluent, glidant etc. pass through After crossing total mix, fill capsule to get.
The Cordyceps militaris capsules, which is characterized in that the cordyceps powder diameter of the step (1) is 20-80
μm。
Drying, crushing and the sterilizing methods of the cordyceps powder will not destroy its effective component.
The drying means of the cordyceps powder is not limited to fluid-bed drying, boulton process, microwave drying, far infrared It is dry.
The Cordyceps militaris capsules, which is characterized in that the cordyceps dried bean noodles drying method temperature of the step (2)≤ 50℃。
The sterilizing methods of the cordyceps powder are not limited to60Co- gamma Rays sterilization, χ ray radiation sterilization, Ultraviolet light sterilization method, ozone gas sterilization, eo sterilization method.
The Cordyceps militaris capsules, which is characterized in that using cordycepin content as the Chinese caterpillar fungus preparation for determining its quality, And it orders into its quality standard.
The Cordyceps militaris capsules, which is characterized in that its cordycepin content measuring method is as follows:
Chromatographic condition and system suitability: being packed column with octadecylsilane chemically bonded silica；Methanol-phosphate-buffered is molten Liquid (pH6.5) (takes 6.8 g of dipotassium hydrogen phosphate, 0.8 g of sodium hydroxide that water is added to be configured to 1000 mL, is 6.5) with phosphoric acid tune pH value It (15: 85) is mobile phase, Detection wavelength is 260 nm, and number of theoretical plate is calculated by cordycepin peak, should be not less than 3000.Reference substance is molten The preparation of liquid: taking cordycepin reference substance appropriate, add methanol be made every 1 mL containing 30 μ g solution to get.The system of test solution It is standby: take this product content appropriate, it is finely ground, about 0.25 g is taken, accurately weighed, 25 mL of methanol, weighed weight, heating is added in precision Reflux 2 hours, lets cool, and weighed weight is supplied the weight of less loss with methanol solution, shaken up, and is filtered with (0.45 μm) of miillpore filter Cross to get.Measuring method: precision draws reference substance solution and each 10 μ L of test solution, injects liquid chromatograph, measurement to get. This product every containing Cordyceps militaris with cordycepin (C10H13N5O3) meter, 0.125 mg must not be less than.
Specific embodiment
In order to which those skilled in the art better understood when technical solution provided by the present invention, these embodiments are only For illustrating the present invention, do not limit the scope of the invention in any way.
Embodiment 1
The preparation method of Cordyceps militaris capsules provided in this embodiment, includes the following steps:
(1) Cordyceps militaris is set in boiling drier, through 45 ± 2 DEG C of fluidized dryings, until moisture is lower than 3%；
(2) Cordyceps militaris first obtains coarse powder after Highefficientpulverizer crushes, and is crushed afterwards using oscillatory ball mill, obtaining partial size is 20-80 μm of cordyceps powder, ball mill parameter are as follows: revolution is 600 turns/min, pot temperature is 15 DEG C, sphere temperature is 20 DEG C, impact bead is zirconium pearl；
(3) it uses60Co- gamma Rays sterilization sterilizes to cordyceps powder；
(4) prescription requirements are pressed, with the good cordyceps powder of electronic balance weighing, starch, silica；
(5) cordyceps powder, starch, silica are poured into biradical seat hopper mixing machine, is sufficiently mixed 30min, obtained total Mixed object；
(6) automatic hard capsule filler is used, total mixture is filled into ebonite utricule, puts on hard capsule cap, by polishing, into Row is aluminum-plastic packaged.
Embodiment 2
The preparation method of Cordyceps militaris capsules provided in this embodiment, includes the following steps:
(1) Cordyceps militaris is set in vacuum oven, is dried in vacuo through 45 ± 2 DEG C, until moisture is lower than 5%；
(2) Cordyceps militaris first obtains coarse powder after Highefficientpulverizer crushes, and is crushed afterwards using oscillatory ball mill, obtaining partial size is 20-80 μm of cordyceps powder, ball mill parameter are as follows: revolution is 600 turns/min, pot temperature is 15 DEG C, sphere temperature is 20 DEG C, impact bead is zirconium pearl；
(3) it uses60Co- gamma Rays sterilization sterilizes to cordyceps powder；
(4) prescription requirements are pressed, with the good cordyceps powder of electronic balance weighing, starch, silica；
(5) cordyceps powder, starch, silica are poured into biradical seat hopper mixing machine, is sufficiently mixed 30 min, obtained total Mixed object；
(6) automatic hard capsule filler is used, total mixture is filled into ebonite utricule, puts on hard capsule cap, by polishing, into Row is aluminum-plastic packaged.
Embodiment 3
The preparation method of Cordyceps militaris capsules provided in this embodiment, includes the following steps:
(1) Cordyceps militaris is set in boiling drier, through 45 ± 2 DEG C of fluidized dryings, until moisture is lower than 5%；
(2) Cordyceps militaris first obtains coarse powder after Highefficientpulverizer crushes, and is crushed afterwards using oscillatory ball mill, obtaining partial size is 20-80 μm of cordyceps powder, ball mill parameter are as follows: revolution is 600 turns/min, pot temperature is 15 DEG C, sphere temperature is 20 DEG C, impact bead is zirconium pearl；
(3) it is sterilized using ultraviolet light sterilization method to cordyceps powder；
(4) prescription requirements are pressed, with the good cordyceps powder of electronic balance weighing, starch, silica；
(5) cordyceps powder, starch, silica are poured into biradical seat hopper mixing machine, is sufficiently mixed 30 min, obtained total Mixed object；
(6) automatic hard capsule filler is used, total mixture is filled into ebonite utricule, puts on hard capsule cap, by polishing, into Row is aluminum-plastic packaged.
Comparative example 1
The preparation method of Cordyceps militaris capsules provided in this embodiment, includes the following steps:
(1) Cordyceps militaris is set in baking oven, through 80 ± 2 DEG C of dryings, until moisture is lower than 5%；
(2) Cordyceps militaris first obtains coarse powder after Highefficientpulverizer crushes, and is crushed afterwards using oscillatory ball mill, obtaining partial size is 20-80 μm of cordyceps powder, ball mill parameter are as follows: revolution is 600 turns/min, pot temperature is 15 DEG C, sphere temperature is 20 DEG C, impact bead is zirconium pearl；
(3) it is sterilized using ultraviolet light sterilization method to cordyceps powder；
(4) prescription requirements are pressed, with the good cordyceps powder of electronic balance weighing, starch, silica；
(5) cordyceps powder, starch, silica are poured into biradical seat hopper mixing machine, is sufficiently mixed 30 min, obtained total Mixed object；
(6) automatic hard capsule filler is used, total mixture is filled into ebonite utricule, puts on hard capsule cap, by polishing, into Row is aluminum-plastic packaged.
Comparative example 2
The preparation method of Cordyceps militaris capsules provided in this embodiment, includes the following steps:
(1) Cordyceps militaris is set in boiling drier, through 45 ± 2 DEG C of fluidized dryings, until moisture is lower than 5%；
(2) Cordyceps militaris first obtains coarse powder after Highefficientpulverizer crushes, and is crushed afterwards using oscillatory ball mill, obtaining partial size is 20-80 μm of cordyceps powder, ball mill parameter are as follows: revolution is 600 turns/min, pot temperature is 15 DEG C, sphere temperature is 20 DEG C, impact bead is zirconium pearl；
(3) sterilizing 2.5 hours is carried out to cordyceps powder in 160 DEG C using hot-air sterilization；
(4) prescription requirements are pressed, with the good cordyceps powder of electronic balance weighing, starch, silica；
(5) cordyceps powder, starch, silica are poured into biradical seat hopper mixing machine, is sufficiently mixed 30 min, obtained total Mixed object；
(6) automatic hard capsule filler is used, total mixture is filled into ebonite utricule, puts on hard capsule cap, by polishing, into Row is aluminum-plastic packaged.
Embodiment and comparative example process characteristic and effective component comparative study result:
Comparison conclusion: in embodiment 1-3, being dried Cordyceps militaris using fluid-bed drying, required time about 1 hour, and right Oven drying is used in ratio 1, it is ten times of fluidized drying time that required time, which is 10.1 hours,；In embodiment 1-3, cordyceps sinensis Element, cordycepic acid, Cordyceps sinensis polysaccharide, ucleosides, amino acid important active constituent content substantially with the Cordyceps militaris without processing Equally, but in comparative example 1-2, each effective component is reduced.Show that the drying of the invention used and sterilizing methods are not only imitated Rate is high and will not destroy the effective component of Cordyceps militaris capsules.
Embodiment 4: cordyceps powder and cordyceps sinensis chemical component compare
(1) nucleosides and its base: the content of cordycepin is higher by 3-5 times than cordyceps sinensis in cordyceps powder, constituent content phase Closely；
(2) cordycepic acid (PEARLITOL 25C): content is 5.96%(g/g in cordyceps powder), cordyceps sinensis 5.47%(g/g), two Person is close；
(3) amino acid: the amino acid contained type of the two is identical, and contains essential amino acid in five, in addition to proline, pupa The content of various amino acid is above cordyceps sinensis in cordyceps, and total content differs nearly 1.7 times；
(4) microelement: all containing the micro elements needed by human in addition to Co in cordyceps powder, cordyceps sinensis；The two is all Rich in Se, content is above Astragalus membranacus.
Embodiment 5: Cordyceps militaris capsules clinical test:
Using mixture of asthenia and sthenia as main pathogenesis characteristics, lung (gas) kidney (sun) two void is chronic bronchitis chronic persistence Chinese medical discrimination It, containing in phlegm wet is its mark, and the state of an illness is slow compared with acute attack stage, in line with the principle of " radical treatment in chronic case ", when with help lung (gas) Kidney (sun), resolving sputum relieving coughing are relievingd asthma for the main rules for the treatment of.Cordyceps militaris capsules, for treat chronic bronchitis chronic persistence, Simple form and type of wheezing, Chinese medical discrimination category Lung Qi deficiency, kidney-yang deficiency sign patient.
From in August, 1994 to December nineteen ninety-five, respectively in Attached Hospital, Changchun Chinese Medicinal College, Jilin Renmin Hospital, Ji Five units such as woods province traditional Chinese medicine research institute clinical hospitals, Changchun institute of traditional Chinese medicine have carried out clinical sight to its curative effect and safety It examines, stricts adhere to controlled observation under observation, random to be grouped, the principle of blind administration observes 268, wherein Cordyceps militaris altogether Bacterium powder capsule treatment group 201, paecilomyces hepiall chen control group 67, treatment group's daily Cordyceps militaris capsules 3 times, every time 4 (1g)；Control group daily paecilomyces hepiall chen 3 times, 4 tablets each time (1g), the course for the treatment of 2 months, after the course for the treatment of, tracing study One Winter-Spring meets case totally 197 that observation requires, wherein Cordyceps militaris capsules treatment group 149, Jinshuibao control group 48, with clinic control, effective, effective, invalid 4 grades of judgements curative effect.
Cordyceps militaris capsules are improving cough, expectoration, are wheezing, the cold limb of shortness of breath, out of strength, spontaneous perspiration, shape as the result is shown for observation While the cardinal symptoms such as cold, waist and knee limb is soft, wheezing sound, rale and sign, improve significantly chest x-ray sign, reduces and rises High body temperature and leucocyte improves lung function, the effect for turning Sputum culturing yin.It coughs, cough up phlegm, wheeze, spontaneous perspiration, sieve improving Sound, tongue nature, tongue fur, chest x-ray sign and make Sputum culturing yin turn etc. due to control group.Improving remaining sings and symptoms, The reverse side such as raised leucocyte and body temperature are reduced, then there was no significant difference compared with the control group, and chronic bronchitis journey 9 years Following person's curative effect be better than 10 years or more persons, the state of an illness and health giving quality analysis shows: without significant difference between the state of an illness and curative effect.
This group 149, clinic control 55,36.90%, effective 27.50% is accounted for, effective 38,25.50% is accounted for, with control group 48, clinic control 9,18.80% is accounted for, effective 7,14.60% is accounted for, effective 22, accounts for 45.80%, comparing, there is very Significant difference (P < 0.01), the clinical observation of 149 patients show that Liver and kidney function without substantially changeing, is not also found before and after treatment Other adverse reactions, confirmation Cordyceps militaris capsules are treatment chronic bronchitis chronic persistence, belong to Lung Qi deficiency deficiency of kidney-YANG syndrome The safe and effective drug waited.
Bibliography
[1] the Cordyceps militaris capsules quality standard State Food and Drug Administration national drug standards, WS3—287 (Z -040) -2005(Z)
[2] Cordyceps militaris capsules special column Chinese Journal of New Drugs, 2004,13(2): 169-174.

Claims (9)

1. a kind of Cordyceps militaris capsules, which is characterized in that the Cordyceps militaris capsules include cordyceps powder, diluent, Glidant.
2. Cordyceps militaris capsules according to claim 1, which is characterized in that its composition is as follows: Cordyceps militaris 100- 30 mg, diluent 20-200 mg, glidant 5-50 mg.
3. Cordyceps militaris according to claim 1, which is characterized in that including cordyceps sinensis substrate and cordyceps species.
4. diluent according to claim 1 can be selected from sucrose, lactose, mannitol, inulin, sorbierite, xylitol, wheat The mixture of one or both of bud dextrin.
5. the mixture that glidant according to claim 1 can be selected from one or both of silica, talcum powder.
6. Cordyceps militaris capsules preparation method according to claim 1 the following steps are included: (1) Cordyceps militaris through dry and Ultramicro crushing treatment obtains cordyceps powder；(2) cordyceps powder sterilizes, spare；(3) cordyceps powder, diluent, Glidant etc. after total mix, fill capsule to get.
7. Cordyceps militaris capsules according to claim 1, which is characterized in that the pupa worm of step described in claim 6 (1) The drying means of grass volvatus powder is not limited to fluid-bed drying, boulton process, microwave drying, far-infrared ray drying.
8. Cordyceps militaris capsules according to claim 1, which is characterized in that the pupa worm of step described in claim 6 (1) Grass volvatus powder drying means temperature≤50 DEG C.
9. Cordyceps militaris capsules according to claim 1, which is characterized in that the pupa worm of step described in claim 6 (2) The sterilizing methods of grass volvatus powder are not limited to60Co- gamma Rays sterilization, χ ray radiation sterilization, ultraviolet light sterilization method, ozone Gas sterilization, eo sterilization method.
CN201810722135.7A 2018-07-04 2018-07-04 A kind of Cordyceps militaris capsules and preparation method thereof Withdrawn CN109646463A (en)

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Publication number Priority date Publication date Assignee Title
CN102232548A (en) * 2011-08-08 2011-11-09 浙江天使生物工程有限公司 Cordyceps militaris-American ginseng capsule health-care product and preparation process thereof
CN104224858A (en) * 2013-10-28 2014-12-24 南京师范大学 Cordyceps militaris microcapsules, cordyceps militaris microcapsule preparation and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102232548A (en) * 2011-08-08 2011-11-09 浙江天使生物工程有限公司 Cordyceps militaris-American ginseng capsule health-care product and preparation process thereof
CN104224858A (en) * 2013-10-28 2014-12-24 南京师范大学 Cordyceps militaris microcapsules, cordyceps militaris microcapsule preparation and preparation method thereof

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Application publication date: 20190419