CN109641897A - Bcl-2选择性抑制剂及其制备和用途 - Google Patents
Bcl-2选择性抑制剂及其制备和用途 Download PDFInfo
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- CN109641897A CN109641897A CN201780053177.XA CN201780053177A CN109641897A CN 109641897 A CN109641897 A CN 109641897A CN 201780053177 A CN201780053177 A CN 201780053177A CN 109641897 A CN109641897 A CN 109641897A
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- base
- methyl
- added
- pyridine
- methylene chloride
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
公开了式(I)所示的化合物:
Description
PCT国内申请,说明书已公开。
Claims (16)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2016108003914 | 2016-09-01 | ||
CN201610800391.4A CN107793412A (zh) | 2016-09-01 | 2016-09-01 | Bcl‑2选择性抑制剂及其制备和用途 |
CN201710604198.8A CN109293656A (zh) | 2017-07-24 | 2017-07-24 | Bcl-2选择性抑制剂及其制备和用途 |
CN2017106041988 | 2017-07-24 | ||
PCT/CN2017/100226 WO2018041248A1 (zh) | 2016-09-01 | 2017-09-01 | Bcl-2选择性抑制剂及其制备和用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109641897A true CN109641897A (zh) | 2019-04-16 |
CN109641897B CN109641897B (zh) | 2021-12-07 |
Family
ID=61300127
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201780053177.XA Active CN109641897B (zh) | 2016-09-01 | 2017-09-01 | Bcl-2选择性抑制剂及其制备和用途 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN109641897B (zh) |
WO (1) | WO2018041248A1 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018127130A1 (en) * | 2017-01-07 | 2018-07-12 | Shanghai Fochon Pharmaceutical Co., Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
HRP20221158T1 (hr) | 2017-04-18 | 2022-12-09 | Shanghai Fochon Pharmaceutical Co., Ltd. | Sredstva za izazivanje apoptoze |
SG11202009933WA (en) | 2018-04-29 | 2020-11-27 | Beigene Ltd | Bcl-2 INHIBITORS |
CA3117849A1 (en) | 2018-10-29 | 2020-05-07 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Trifluoromethyl-substituted sulfonamide as bcl-2-selective inhibitor |
CN111747949B (zh) * | 2019-03-29 | 2022-07-01 | 首药控股(北京)股份有限公司 | Bcl-2选择性抑制剂的制备方法 |
US20220388977A1 (en) * | 2019-06-14 | 2022-12-08 | Beijing Shenogen Pharma Group Ltd. | Shp2 phosphatase allosteric inhibitor |
CN114057728A (zh) | 2020-08-06 | 2022-02-18 | 北京诺诚健华医药科技有限公司 | 作为bcl-2抑制剂的杂环化合物 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102448959A (zh) * | 2009-05-26 | 2012-05-09 | 雅培制药有限公司 | 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 |
CN103153993A (zh) * | 2010-05-26 | 2013-06-12 | Abbvie公司 | 治疗癌症和免疫与自身免疫疾病的细胞程序死亡诱导药剂 |
CN105026394A (zh) * | 2013-03-14 | 2015-11-04 | 艾伯维公司 | 用于治疗癌症和免疫性和自身免疫性疾病的细胞凋亡诱导剂 |
-
2017
- 2017-09-01 WO PCT/CN2017/100226 patent/WO2018041248A1/zh active Application Filing
- 2017-09-01 CN CN201780053177.XA patent/CN109641897B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102448959A (zh) * | 2009-05-26 | 2012-05-09 | 雅培制药有限公司 | 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 |
CN103153993A (zh) * | 2010-05-26 | 2013-06-12 | Abbvie公司 | 治疗癌症和免疫与自身免疫疾病的细胞程序死亡诱导药剂 |
CN105026394A (zh) * | 2013-03-14 | 2015-11-04 | 艾伯维公司 | 用于治疗癌症和免疫性和自身免疫性疾病的细胞凋亡诱导剂 |
Also Published As
Publication number | Publication date |
---|---|
WO2018041248A1 (zh) | 2018-03-08 |
CN109641897B (zh) | 2021-12-07 |
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