CN109620774A - A kind of herbal mixture care toothpaste and preparation method thereof - Google Patents
A kind of herbal mixture care toothpaste and preparation method thereof Download PDFInfo
- Publication number
- CN109620774A CN109620774A CN201910080617.1A CN201910080617A CN109620774A CN 109620774 A CN109620774 A CN 109620774A CN 201910080617 A CN201910080617 A CN 201910080617A CN 109620774 A CN109620774 A CN 109620774A
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- Prior art keywords
- parts
- extract
- herbal mixture
- care toothpaste
- lotion
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Abstract
The invention discloses a kind of herbal mixture care toothpaste, each component including following parts by weight: 0.5-1.4 parts of selenium worm grass extract, 2-5 parts of Folium Isatidis extract, 1-3 parts of Rhizoma Bistortae extract, 2-5 parts of eucommia ulmoides extracts, 0.5-1 parts of vitamin B, 75-85 parts of substrate and 7-9 parts of deionized water；Wherein, the substrate is made of rubbing agent, moisturizer, adhesive, foaming agent, sweetener and preservative.The invention also discloses a kind of preparation methods of herbal mixture care toothpaste.Herbal mixture care toothpaste of the invention can effectively reduce plaque, inhibit the generation of bacterium, and can effective pre- preventing parodontitis, canker sore, the oral cavities such as halitosis common disease.
Description
Technical field
The present invention relates to field of toothpaste, in particular to a kind of herbal mixture care toothpaste and preparation method thereof.
Background technique
As the improvement of people's living standards, a series of diseases in oral cavity are also following, periodontosis, oral cavity common are
Ulcer, gingivitis, halitosis, wherein most ailments are all caused by bacterium or related with bacterium, so nursing oral cavity is mainly answered
From sterilization, antibacterial aspect is set about, and traditional Chinese medicine ingredients of the present invention have antibiotic effect, and collaboration uses, and is aided with biological element-
Selenium, increase significant in efficacy, and side effect harmless to the human body.
Summary of the invention
The object of the present invention is to provide a kind of herbal mixture care toothpaste of antibacterial anti-inflammatory, each group including following parts by weight
Point: 0.5-1.4 parts of selenium worm grass extract, 2-5 parts of Folium Isatidis extract, 1-3 parts of Rhizoma Bistortae extract, 2-5 parts of eucommia ulmoides extracts, dimension
Raw 0.5-1 parts of element B, 75-85 parts of substrate and 7-9 parts of deionized water；Wherein, the substrate is by rubbing agent, moisturizer, bonding
Agent, foaming agent, sweetener and preservative composition.
The substrate is by weight by 35-60 parts of rubbing agent, 15-40 parts of moisturizer, 0.5-1.5 parts of adhesive, foaming
1-3 parts of agent, 2-3 parts of sweetener and 1-5 parts of preservative compositions.
The selenium worm grass extract or Folium Isatidis extract or Rhizoma Bistortae extract or eucommia ulmoides extracts the preparation method comprises the following steps: first
Selenium worm grass or folium isatidis or adder-wort or Cortex Eucommiae are cleaned, selected, is crushed, is decocted and filter, mass percent is added into filtrate
For 75% ethyl alcohol, it is heated to boiling reflux 2h, acquired solution is stood into 10h, 2000rpm centrifugation is concentrated under reduced pressure into relative density
For the thick paste of 1.2-1.25, obtains the selenium worm grass extract or Folium Isatidis extract or Rhizoma Bistortae extract or Cortex Eucommiae is extracted
Object.
The rubbing agent is made of one or more of calcium carbonate, hydrated silica, calcium pyrophosphate, aluminium hydroxide.
Described adhesive is by one or more of carragheen, xanthan gum, cellulose gum, sodium carboxymethylcellulose group
At.
The foaming agent is by sldium lauryl sulfate, sodium lauroyl sarcosine, sodium dihydrogen phosphate, cocamidopropyl propyl amide beet
One or more of alkali composition.
The moisturizer is made of one or more of glycerol, polyethylene glycol-400, sorbierite, propylene glycol.
The sweetener is made of one or more of saccharin sodium, xylitol, Aspartame.
The preservative is by ethyl-para-hydroxybenzoate, propylparaben, butyl p-hydroxybenzoate
One or more composition.
A kind of preparation method of herbal mixture care toothpaste, comprising the following steps:
S1, by the selenium worm grass extract, Folium Isatidis extract, Rhizoma Bistortae extract, eucommia ulmoides extracts, moisturizer, rubbing agent, add
Enter in emulsion pot, adds deionized water to stir and prepared to being completely dissolved uniformly in the glue of viscous shape, storage is spare；
S2, the glue is taken out in addition vacuum Manufacturing medicine extract machine, starts vacuum Manufacturing medicine extract machine, when vacuum degree reaches -0.90 MPa,
Close vacuum；
S3, foaming agent, adhesive, vitamin B are added to vacuum Manufacturing medicine extract machine, starting scraper is stirred, and control whipping temp is
65 DEG C -75 DEG C, stirring rate 1800-2200rpm persistently stirs 10-15min, obtains primary lotion；
After the completion of S4, stirring, using grinder grinding S3 obtained in primary lotion, grinding 25-30min, be fully ground so that
Lotion is fine and smooth, uniformly；
S5, by sweetener, preservative and S4 grind after primary lotion be slowly added in vacuum Manufacturing medicine extract machine, starting scraper into
Row stirring, holding vacuum degree are -0.1MPa, and stirring rate 1300-1500rpm, mixing time 30-40min obtain second level
Lotion；
S6, gained second level lotion in S5 is de-gassed, until vacuum degree reaches -0.1MPa, degassing time 40-
50min is stood；
S7, the second level lotion after deaerating in S6 is aged, after the assay was approved, sterile loading packing tube obtains in the compound
Medicine care toothpaste.
Advantages of the present invention: being all by bacterium, caused by plaque about the overwhelming majority in a series of diseases in oral cavity.
Research find effective component cordycepin and cordycepic acid in cordyceps sinensis have good antibacterial, bacteriostasis, and cordycepin with it is anti-inflammatory
Disease is also closely connected.The more common cordyceps sinensis of selenium worm grass functional component cordycepin after selenium-rich is higher by about 40 times, biological element-selenium
More there is improvement microcirculation, improves immune curative effect.In addition, oral cavity common disease ,-canker sore is obviously experienced as to people's-aches,
Adder-wort of the present invention not only has an anti-inflammatory, the effect of antibacterial, and there are also good analgesic effect, analgesic effect can be with
Coffee is suitable, can be very good the feeling of pain for mitigating ulcers.Clinical test results point out the effective component catechin of adder-wort also
It can obviously reduce plaque and slow down periodontosis.It is equipped with the effect of Cortex Eucommiae can accelerate wound healing again, to treatment canker sore
And all kinds of diseases as caused by bacterium, inflammation have good curative effect.
Specific embodiment
A kind of herbal mixture care toothpaste of antibacterial anti-inflammatory, each component including following parts by weight: selenium worm grass extract
0.5-1.4 parts, 2-5 parts of Folium Isatidis extract, 1-3 parts of Rhizoma Bistortae extract, 2-5 parts of eucommia ulmoides extracts, 0.5-1 parts of vitamin B,
75-85 parts of substrate and 7-9 parts of deionized water；Wherein, the substrate is by rubbing agent, moisturizer, adhesive, foaming agent, sweet taste
Agent and preservative composition.
The substrate is by weight by 35-60 parts of rubbing agent, 15-40 parts of moisturizer, 0.5-1.5 parts of adhesive, foaming
1-3 parts of agent, 2-3 parts of sweetener and 1-5 parts of preservative compositions.
The selenium worm grass extract or Folium Isatidis extract or Rhizoma Bistortae extract or eucommia ulmoides extracts the preparation method comprises the following steps: first
Selenium worm grass or folium isatidis or adder-wort or Cortex Eucommiae are cleaned, selected, is crushed, is decocted and filter, mass percent is added into filtrate
For 75% ethyl alcohol, it is heated to boiling reflux 2h, acquired solution is stood into 10h, 2000rpm centrifugation is concentrated under reduced pressure into relative density
For the thick paste of 1.2-1.25, obtains the selenium worm grass extract or Folium Isatidis extract or Rhizoma Bistortae extract or Cortex Eucommiae is extracted
Object.
The rubbing agent is made of one or more of calcium carbonate, hydrated silica, calcium pyrophosphate, aluminium hydroxide.
Described adhesive is by one or more of carragheen, xanthan gum, cellulose gum, sodium carboxymethylcellulose group
At.
The foaming agent is by sldium lauryl sulfate, sodium lauroyl sarcosine, sodium dihydrogen phosphate, cocamidopropyl propyl amide beet
One or more of alkali composition.
The moisturizer is made of one or more of glycerol, polyethylene glycol-400, sorbierite, propylene glycol.
The sweetener is made of one or more of saccharin sodium, xylitol, Aspartame.
The preservative is by ethyl-para-hydroxybenzoate, propylparaben, butyl p-hydroxybenzoate
One or more composition.
A kind of preparation method of herbal mixture care toothpaste, comprising the following steps:
S1, by the selenium worm grass extract, Folium Isatidis extract, Rhizoma Bistortae extract, eucommia ulmoides extracts, moisturizer, rubbing agent, add
Enter in emulsion pot, adds deionized water to stir and prepared to being completely dissolved uniformly in the glue of viscous shape, storage is spare；
S2, the glue is taken out in addition vacuum Manufacturing medicine extract machine, starts vacuum Manufacturing medicine extract machine, when vacuum degree reaches -0.90 MPa,
Close vacuum；
S3, foaming agent, adhesive, vitamin B are added to vacuum Manufacturing medicine extract machine, starting scraper is stirred, and control whipping temp is
65 DEG C -75 DEG C, stirring rate 1800-2200rpm persistently stirs 10-15min, obtains primary lotion；
After the completion of S4, stirring, using grinder grinding S3 obtained in primary lotion, grinding 25-30min, be fully ground so that
Lotion is fine and smooth, uniformly；
S5, by sweetener, preservative and S4 grind after primary lotion be slowly added in vacuum Manufacturing medicine extract machine, starting scraper into
Row stirring, holding vacuum degree are -0.1MPa, and stirring rate 1300-1500rpm, mixing time 30-40min obtain second level
Lotion；
S6, gained second level lotion in S5 is de-gassed, until vacuum degree reaches -0.1MPa, degassing time 40-
50min is stood；
S7, the second level lotion after deaerating in S6 is aged, after the assay was approved, sterile loading packing tube obtains in the compound
Medicine care toothpaste.
<embodiment 1>
0.5 part of selenium worm grass extract, 2 parts of Folium Isatidis extract, 1 part of Rhizoma Bistortae extract, 2 parts of eucommia ulmoides extracts, vitamin B 0.5
Part, 75 parts of substrate, 7 parts of deionized water；
Wherein, in per hundred parts by weight substrate: 55 parts of calcium carbonate of rubbing agent selection, 20 parts of glycerol of moisturizer selection, 20 parts of sorbierite,
Adhesive selects 1 part of carragheen, and 1 part of cellulose gum, foaming agent selects 1 part of sldium lauryl sulfate, and sweetener selects saccharin sodium 1
Part, preservative selects 1 part of ethyl-para-hydroxybenzoate.Lotion is made referring to above step.
<embodiment 2>
1.4 parts of selenium worm grass extract, 5 parts of Folium Isatidis extract, 3 parts of Rhizoma Bistortae extract, 5 parts of eucommia ulmoides extracts, vitamin B1 part,
85 parts of substrate, 8 parts of deionized water；
Wherein, in per hundred parts by weight substrate: 48 parts of calcium carbonate of rubbing agent selection, 18 parts of glycerol of moisturizer selection, 20 parts of sorbierite,
Adhesive selects 1 part of carragheen, and 0.7 part of cellulose gum, foaming agent selects 3 parts of sldium lauryl sulfate, and sweetener selects saccharin sodium
2.7 parts, preservative selects 5 parts of ethyl-para-hydroxybenzoate.Lotion is made referring to above step.
<embodiment 3>
1.2 parts of selenium worm grass extract, 5 parts of Folium Isatidis extract, 1.9 parts of Rhizoma Bistortae extract, 4.3 parts of eucommia ulmoides extracts, vitamin B
0.6 part, 80 parts of substrate, 9 parts of deionized water；
Wherein, in per hundred parts by weight substrate: rubbing agent selects 50 parts of calcium pyrophosphate, and moisturizer selects 20 parts of propylene glycol, sorbierite
20 parts, adhesive selects 0.7 part of sodium cellulose glycolate, and 1 part of cellulose gum, foaming agent selects 2.5 parts of sodium dihydrogen phosphate, sweet taste
Agent selects 3 parts of Aspartame, and preservative selects 2.8 parts of butyl p-hydroxybenzoate.Lotion is made referring to above step.
<test data>
Bacteriostatic experiment is carried out with the herbal mixture care toothpaste that above-described embodiment 3 is prepared.Object is periodontitis, canker sore, mouth
Smelly, each 20 people of gingivitis patients takes bacterium using deep cough method, carries out blood plate culture, and measurement zone of hemolysis area obtains following data.
Claims (10)
1. a kind of herbal mixture care toothpaste, it is characterised in that each component including following parts by weight: selenium worm grass extract 0.5-
1.4 parts, 2-5 parts of Folium Isatidis extract, 1-3 parts of Rhizoma Bistortae extract, 2-5 parts of eucommia ulmoides extracts, 0.5-1 parts of vitamin B, substrate
75-85 parts and 7-9 parts of deionized water；Wherein, the substrate by rubbing agent, moisturizer, adhesive, foaming agent, sweetener with
And preservative composition.
2. a kind of herbal mixture care toothpaste according to claim 1, it is characterised in that the substrate by weight by
35-60 parts of rubbing agent, 15-40 parts of moisturizer, 0.5-1.5 parts of adhesive, 1-3 parts of foaming agent, 2-3 parts of sweetener and preservative
1-5 parts of compositions.
3. a kind of herbal mixture care toothpaste according to claim 1, it is characterised in that the selenium worm grass extract is big
Leafiness extract or Rhizoma Bistortae extract or eucommia ulmoides extracts the preparation method comprises the following steps: first by selenium worm grass or folium isatidis or adder-wort or Cortex Eucommiae
Removal of impurities, is selected, and is crushed, is decocted and filter, and the ethyl alcohol that mass percent is 75% is added into filtrate, is heated to boiling reflux 2h,
Acquired solution is stood into 10h, 2000rpm centrifugation is concentrated under reduced pressure into the thick paste that relative density is 1.2-1.25, obtains the selenium
Cordyceps or Folium Isatidis extract or Rhizoma Bistortae extract or eucommia ulmoides extracts.
4. a kind of herbal mixture care toothpaste according to claim 1, it is characterised in that the rubbing agent be by calcium carbonate,
One or more of hydrated silica, calcium pyrophosphate, aluminium hydroxide composition.
5. a kind of herbal mixture care toothpaste according to claim 1, it is characterised in that described adhesive be by carragheen,
One or more of xanthan gum, cellulose gum, sodium carboxymethylcellulose composition.
6. a kind of herbal mixture care toothpaste according to claim 1, it is characterised in that the foaming agent is by laruyl alcohol
One or more of sodium sulphate, sodium lauroyl sarcosine, sodium dihydrogen phosphate, Cocoamidopropyl betaine composition.
7. a kind of herbal mixture care toothpaste according to claim 1, it is characterised in that the moisturizer is by glycerol, gathers
One or more of ethylene glycol -400, sorbierite, propylene glycol composition.
8. a kind of herbal mixture care toothpaste according to claim 1, it is characterised in that the sweetener be by saccharin sodium,
One or more of xylitol, Aspartame composition.
9. a kind of herbal mixture care toothpaste according to claim 1, it is characterised in that the preservative is by hydroxyl
One or more of ethyl benzoate, propylparaben, butyl p-hydroxybenzoate composition.
10. a kind of preparation method of herbal mixture care toothpaste according to claim 1, it is characterised in that including following step
It is rapid:
S1, by the selenium worm grass extract, Folium Isatidis extract, Rhizoma Bistortae extract, eucommia ulmoides extracts, moisturizer, rubbing agent, add
Enter in emulsion pot, adds deionized water to stir and prepared to being completely dissolved uniformly in the glue of viscous shape, storage is spare；
S2, the glue is taken out in addition vacuum Manufacturing medicine extract machine, starts vacuum Manufacturing medicine extract machine, when vacuum degree reaches -0.90 MPa,
Close vacuum；
S3, foaming agent, adhesive, vitamin B are added to vacuum Manufacturing medicine extract machine, starting scraper is stirred, and control whipping temp is
65 DEG C -75 DEG C, stirring rate 1800-2200rpm persistently stirs 10-15min, obtains primary lotion；
After the completion of S4, stirring, using grinder grinding S3 obtained in primary lotion, grinding 25-30min, be fully ground so that
Lotion is fine and smooth, uniformly；
S5, by sweetener, preservative and S4 grind after primary lotion be slowly added in vacuum Manufacturing medicine extract machine, starting scraper into
Row stirring, holding vacuum degree are -0.1MPa, and stirring rate 1300-1500rpm, mixing time 30-40min obtain second level
Lotion；
S6, gained second level lotion in S5 is de-gassed, until vacuum degree reaches -0.1MPa, degassing time 40-
50min is stood；
S7, the second level lotion after deaerating in S6 is aged, after the assay was approved, sterile loading packing tube obtains in the compound
Medicine care toothpaste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910080617.1A CN109620774A (en) | 2019-01-28 | 2019-01-28 | A kind of herbal mixture care toothpaste and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910080617.1A CN109620774A (en) | 2019-01-28 | 2019-01-28 | A kind of herbal mixture care toothpaste and preparation method thereof |
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| Publication Number | Publication Date |
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| CN109620774A true CN109620774A (en) | 2019-04-16 |
Family
ID=66062405
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| CN201910080617.1A Pending CN109620774A (en) | 2019-01-28 | 2019-01-28 | A kind of herbal mixture care toothpaste and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110507572A (en) * | 2019-08-21 | 2019-11-29 | 两面针（江苏）实业有限公司 | A kind of bacteriostasis, and deodorization toothpaste and preparation method thereof |
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| CN106937925A (en) * | 2017-03-03 | 2017-07-11 | 江苏康缘药业股份有限公司 | A kind of compound traditional Chinese medicine composite and toothpaste containing the compound traditional Chinese medicine composite and preparation method thereof |
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2019
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110507572A (en) * | 2019-08-21 | 2019-11-29 | 两面针（江苏）实业有限公司 | A kind of bacteriostasis, and deodorization toothpaste and preparation method thereof |
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Application publication date: 20190416 |