CN109602888A - A kind of abdomen is releived essential oil composition and massage cream and preparation method thereof - Google Patents
A kind of abdomen is releived essential oil composition and massage cream and preparation method thereof Download PDFInfo
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- CN109602888A CN109602888A CN201910104241.3A CN201910104241A CN109602888A CN 109602888 A CN109602888 A CN 109602888A CN 201910104241 A CN201910104241 A CN 201910104241A CN 109602888 A CN109602888 A CN 109602888A
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- essential oil
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- abdomen
- massage cream
- releived
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
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- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
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Abstract
It releives essential oil composition and massage cream and preparation method thereof the invention discloses a kind of abdomen.The abdomen releives essential oil composition with the ginger essential oil of reasonable amount, black pepper essential oil, Geranium Essential, clary sage essential oil, Lavender, fragrant camphor tree leaf essential oil progress compatibility, performance has effects that warm palace, alleviates dysmenorrhea, it is aided with the ingredients such as moisturizer, skin conditioning agent, water again abdomen is made and releive essential oil massage cream, goes back compatibility with a variety of skin-moisturizing, skin ingredients.The massage cream has the characteristics that be easy to absorb good, gently abdomen massage skin when use, that is, can reach nursing of releiving, skin of abdomen feels the effect of smooth exquisiteness.
Description
Technical field
The present invention relates to feminine care products technical field, more particularly, to a kind of abdomen releive essential oil composition and
Massage cream and preparation method thereof.
Background technique
Dysmenorrhea refers to that women passes through front and back or lower abdominal pain, falling inflation occurs in the menstrual period, with the soreness of waist or other uncomfortable, diseases
Shape seriously affects quality of life person.Dysmenorrhea is divided into primary pain and secondary two class, wherein primary dysmenorrhea is puberty women
In one of the most common gynecological disease, incidence is between 30%~50%, and there are about 10% or so patient, pain is difficult to endure,
Monthly have 1~3 day or longer time cisco unity malfunction, life, it is necessary to receive treatment.
Currently, the cause of disease and pathogenesis of dysmenorrhea are not clear, the treatment method of special specification is also lacked, mainly
Symptomatic treatment, main drug treatment are as follows: (1) the common drug of prostaglandin synthase inhibitor has brufen, ketone Lip river
Sweet smell, Meclofenamic Acid, Diclofenac etc..(2) oral contraceptive, suitable for requiring the dysmenorrhea women of contraception.However, being used for a long time
Analgestic may cause drug resistance, therefore, will if can find the alleviation of auxiliary or treat the more efficient method of dysmenorrhea
It is the Gospel of female friend.
Essential oil can say be plant hormone, it possesses composition substance identical with the mankind and life energy, essential oil molecule
Superfine, penetration is high, so the extremely effective disengaging body of energy, it will not be residual as chemicals according to studies have shown that essential oil
It stays in the body, it is by just urine, perspiration, exhales and be discharged, and the time of discharge needs about several hours.The study found that with
Antitetanic essential oil is gently massaged in abdomen, usually can soon dissolve dysmenorrhea.But it is different essential oil alleviating dysmenorrhea, resisting
May also have a variety of different effects such as menstruation regulating while spasm, that is to say, that the essential oil having can promote the menstrual cycle just
Often, what is had can increase menses flow, and some essential oils adjustable menstrual cycle ... is for example, for through blood flow just
Normal or higher women will avoid treating dysmenorrhea through this kind of essential oil of blood flow using increase, in order to avoid accidentally make to increase through blood flow.
Therefore, using essential oil alleviate dysmenorrhea during, need the compatibility type to essential oil, proportion compatibility and with essential oil compatibility
Other compositions carry out system research.
According to theory of traditional Chinese medical science, human abdomen has 7 yin channel to cross (six YIN meridians and a conception vessel), is congenital to be easiest to tremble with fear
Solidifying place.Chinese medicine thinks: yin belong to it is cold, cold then coagulate, it is solidifying then tie, tie then it is poly or poly it is then obstructed, general rule is not bitterly.Cold and cool abdomen is to lead
The maximum reason of abdominal obesity, channels and collaterals blocking is caused, abdomen is the container of human five internal organs' six internal organs.Including spleen, stomach, liver, gallbladder, kidney,
The internal organs such as bladder, large intestine, small intestine, uterus, if abdomen blockage of main and collateral channels, temperature is too low, can all influence internal organs function.And abdomen
Direct effect can be played to the chronic disease for improving these internal organs by maintaining, including gynecological organs such as uterus.TCM investigation
Think, dysmenorrhea, irregular menstruation have the gynaecological problems such as clot and abdomen blockage of main and collateral channels, cold solidifying cohesion to have direct relation.
Summary of the invention
The technical problem to be solved by the present invention is to for the technology for alleviating and treating the gynaecological problems such as dysmenorrhea in the prior art
Deficiency, the present invention provide a kind of abdomen and releive essential oil composition.
Another technical problem to be solved by the present invention is that providing the application that the abdomen releives essential oil composition.
The invention solves an also technical problem be to provide a kind of abdomen and releive essential oil massage cream.
The invention solves an also technical problem be to provide the abdomen and releive the preparation method of essential oil massage cream.
The purpose of the present invention is achieved through the following technical solutions:
It provides a kind of abdomen to releive essential oil composition, be grouped as by each group of following parts by weight: 10~30 parts of ginger essential oil,
10~30 parts of black pepper essential oil, 5~20 parts of Geranium Essential, 5~20 parts of clary sage essential oil, 1~10 part of Lavender,
1~5 part of fragrant camphor tree leaf essential oil.
Abdomen of the present invention is releived in essential oil composition, ginger essential oil and black pepper essential oil is compounded, wherein ginger extract
Oil has analgesia and depth heating effect, moreover it is possible to and stimulation cycle system, expansion blood vessel prevent the characteristics such as internal organ spasm and ventilation,
Play the role of warm palace, analgesic anti-spasm in inventive formulation, transfers body QI-blood circulation；Black pepper essential oil is for Menstruation reaction
The symptoms such as caused dysmenorrhea, Anemia, diarrhea abdominal distension, DOMS, neuralgia, nauseous gastric disorder causing nausea, spasm are effective, in the present invention
In formula, black pepper essential oil and ginger essential oil are combined according to reasonable ratio, play coordinated effect, moreover it is possible to promote blood
It recycles, is promoting blood circulation and removing obstruction in channels, while playing the role of warm palace, nourishing uterus.
Alleviate dysmenorrhea effect further to play collaboration, also cooperates a certain proportion of happy rat-tail in the essential oil composition
The natural plants essential oils such as careless essential oil, Lavender and fragrant camphor tree leaf essential oil, wherein clary sage essential oil has oestrogen-like hormone,
There is menstruation regulating ability, while in terms of urogenital system, the problem of dysmenorrhea, labor pain, blood volume deficiency, menopause can be risen
To good result, moreover it is possible to alleviate and premenstrual constrain, feel exhausted and the symptoms such as migraine；Lavender can alleviate stomach convulsion
The symptoms such as contraction, eilema, indigestion, flatulence, nausea, moreover it is possible to be effectively relieved that menses are insufficient, dysmenorrhoea, premenstrual symptom, dizziness, partially
Headache etc.；In fragrant camphor tree leaf essential oil contain the similar left-handed linalool of high concentration, have effects that loosen body and mind, there are also anti-spasm,
Antianxiety slows down the functions such as ballism disease, by suitable clary sage essential oil, Lavender and fragrant camphor tree leaf essential oil and ginger extract
Oil, black pepper essential oil compatibility have synergistic function in terms of enhancing warm Gong Xiaoguo, anti-spasm analgesic, are effectively improved dysmenorrhea
Bring passiveness and nervous symptom.
In order to reconcile it is many fragrant promote fusion, the essential oil composition is also added with Geranium Essential, for female reproductive system
System problem, climacteric problem and estrogen regulation of secretion problem, make it in the compatibility of integrated system of the present invention, Ke Yifa
Shoot the extraordinary balanced action of Geranium Essential.
It is further preferred that the abdomen is releived, essential oil composition is grouped as by each group of following parts by weight: ginger essential oil
15~25 parts, 15~25 parts of black pepper essential oil, 8~15 parts of Geranium Essential, 8~15 parts of clary sage essential oil, lavender essence
1~5 part of oil, fragrant 1~2 part of essential oil of camphor tree leaf.
It is further preferred that the abdomen is releived, essential oil composition is grouped as by each group of following parts by weight: ginger essential oil
15~20 parts, 15~20 parts of black pepper essential oil, 10~15 parts of Geranium Essential, 10~15 parts of clary sage essential oil, lavender
3~5 parts of essential oil, fragrant 1~2 part of essential oil of camphor tree leaf.
Most preferably, abdomen essential oil composition of releiving is grouped as by each group of following parts by weight: 18 parts of ginger essential oil,
16 parts of black pepper essential oil, 12 parts of Geranium Essential, 12 parts of clary sage essential oil, 3 parts of Lavender, fragrant 1 part of essential oil of camphor tree leaf.
The present invention is based on the essential oil compositions, provide a kind of application well, the essential oil composition is applied to system
Standby abdominal massaging cream.
The present invention provides a kind of abdomen and releives essential oil massage cream, each component including following parts by weight: essential oil composition 2~
12 parts, 3~6 parts of thickener, 1~4 part of emulsifier, 4~8 parts of emollient, 0.5~1 part of preservative, 10~20 parts of moisturizer, skin
1~2 part of skin conditioner, 0.05~0.1 part of chelating agent, 0.5~2 part of antioxidant, 60~80 parts of water.
Preferably, the abdomen releive essential oil massage cream include following parts by weight each component: it is as claimed in claim 1 or 2
4~10 parts of essential oil composition, 3~5 parts of thickener, 2~4 parts of emulsifier, 6~8 parts of emollient, 0.8~1 part of preservative, moisturizing
12~15 parts of agent, 1.5~1.8 parts of skin conditioning agent, 0.08~0.1 part of chelating agent, 1~1.5 part of antioxidant, water 70~80
Part.
It is further preferred that the thickener is made of 2.5~4 parts of cetostearyl alcohol, 0.1~2 part of xanthan gum.
It is further preferred that the emulsifier by 0.5~1.5 part of cetearyl glucoside, stearine 0.2~
1 part, 0.2~1 part of the stearate of PEG~100,0.1~0.8 part of inulin lauryl carbamate composition.
It is further preferred that the emollient is by 3~5 parts of caprylic/capric triglyceride, 1~3 part of dimethyl silicone polymer
Composition.
It is further preferred that the preservative is made of 0.1~1 part of Phenoxyethanol, 0.5~1 part of pungent glycol.
It is further preferred that the moisturizer is glycerol, the skin conditioning agent is tocopherol acetate, the chelating agent
For EDETATE SODIUM, the antioxidant is Butylated Hydroxytoluene.
Abdomen of the invention releive essential oil massage cream also include caprylic/capric triglyceride, dimethyl silicone polymer and
A variety of skin-moisturizing, skin ingredients such as glycerol compound with having the essential oil composition in warm palace, alleviation dysmenorrhea effect, will not destroy essential oil
Speciality obtains the Function of essential oil more preferably.Wherein, caprylic/capric triglyceride has compatible feature with human skin,
So that skin lubrication and softness, are added into massage cream, the multiple efficacies such as massage cream skin care, moisturizing are assigned.
The abdomen releive essential oil massage cream can under the essential idea of compatibility of the present invention, using this field is existing can be real
Existing technological means is prepared.
It releives the preferred preparation method of essential oil massage cream present invention simultaneously provides the abdomen, comprising the following steps:
S1. essential oil composition, emollient, chelating agent, antioxidant, preservative and partial emulsifier are thrown by said ratio
Enter in oily phase agitated kettle, mixing speed is 25~35rpm, is warming up to 80~85 DEG C, and mixing time is 30~35min, obtains A
Phase；
S2. by said ratio by water, moisturizer, skin conditioning agent, thickener investment water phase agitated kettle, mixing speed is
25~35rpm is warming up to 80~85 DEG C, and mixing time is 30~35min, obtains B phase；
S3. the A phase in step S1, S2 is placed in emulsion pot with B phase, homogeneous for a period of time after, carry out vacuum defoamation at
It is cooling after reason；
S4. after being cooled to 48 DEG C, be added remainder emulsifier, mixing speed be 25~35rpm, mixing time be 30~
35min, discharging, obtains semi-finished product；
S5. semi-finished product are tested, are filling, packaging after to get.
It is further preferred that in step S3, the homogenizing time is 3~5min, the vacuum defoamation processing time is 8~
12min。
It is further preferred that in step S5, by semi-finished product after the assay was approved by every dress 10g metering, manual filling, dress
Good bottle cap, then by product be packed into PVC bubble-cap shell carry out plastic uptake heat sealing to get.
Compared with prior art, the beneficial effects of the present invention are:
The present invention provides a kind of abdomen with multiple efficacies and releives essential oil composition, passes through ginger essential oil, black pepper essence
Oil, Lavender, Geranium Essential, clary sage essential oil, fragrant camphor tree leaf essential oil carry out coordinated according to reasonable ratio,
The present invention passes through long term test, and the components compatibility is formed essential oil composition according to reasonable dosage, is not only able to effectively slow
Solve dysmenorrhea bring sense of discomfort, moreover it is possible to play the effect in nourishing uterus, warm palace.Not only there is very strong fat-soluble and osmotic energy
Power is quickly absorbed by body, and there is pungent perfume (or spice) to walk to alter, and fragrant qi-regulating and promoting blood circulation and stopping pain effect, analgesic regulating menoxenia is significant, together
When can also be simple and efficient by external medication, avoid in the prior art using essential oil generate have a single function, do not suit the medicine to the illness or
Person influences excessive technical problem on blood volume, and numerous women acceptance is higher, and compliance is stronger.
The present invention is in the technical foundation of the essential oil composition, and the present invention is by the mode of essential oil composition and abdominal massaging
Scientifically be combined together, by thickener, emulsifier, emollient, preservative, moisturizer, skin conditioning agent, chelating agent,
The analysis and research of the dosage of antioxidant and water are compounded with having the essential oil composition in warm palace, alleviation dysmenorrhea effect, described to press
The cream that rubs has the characteristics that be easy to absorb good, gently abdomen massage skin when use can reach nursing of releiving, skin of abdomen sense
Feel the effect of smooth exquisiteness.
Abdomen provided by the invention is releived the preparation method simple process of essential oil massage cream, easy to operate, can be suitable for
Industrialized production, high production efficiency.
Specific embodiment
To facilitate the understanding of the present invention, present invention work more comprehensively, is meticulously described below in conjunction with embodiment, but this hair
Bright protection scope is not limited to embodiment in detail below.
Unless otherwise defined, all technical terms used hereinafter and the normally understood meaning of those skilled in the art
It is identical.Technical term used herein is intended merely to the purpose of description specific embodiment, it is no intended to limit of the invention
Protection scope.
For convenience of description, it is exemplified below heretofore described primary raw material as follows, unless stated otherwise its preparation side
Method is commercially available.Specifically:
Cetostearyl alcohol, regular market purchase, No. CAS: 8005~44~5.
Xanthan gum, regular market purchase, No. CAS: 11138~66~2.
Cetearyl glucoside, regular market purchase, No. CAS: 246159~33~1.
Stearine, regular market purchase, No. CAS: 123~94~4.
The stearate of PEG~100, regular market purchase, No. CAS: 9004~99~3.
Inulin lauryl carbamate, regular market purchase, No. CAS: 478483~27~1.
Caprylic/capric triglyceride, regular market purchase, No. CAS: 65381~09~1.
Dimethyl silicone polymer, regular market purchase, No. CAS: 63148~62~9.
Phenoxyethanol, regular market purchase, No. CAS: 122~99~6.
Pungent glycol, regular market purchase, No. CAS: 1117~86~8.
Glycerol, regular market purchase, No. CAS: 56~81~5.
Tocopherol acetate, regular market purchase, No. CAS: 58~95~7.
EDETATE SODIUM, regular market purchase, No. CAS: 139~33~3.
Butylated Hydroxytoluene, regular market purchase, No. CAS: 128~37~0.
One of optionally, black pepper essential oil, Lavender, fragrant camphor tree leaf essential oil, India in following embodiment
Certain herbaceous plants with big flowers essential oil, clary sage essential oil, ginger essential oil extract by the following method:
Black pepper essential oil: black pepper is placed in distilling apparatus and carries out air-distillation, 105 DEG C are warming up to, until condensing droplet
On a glass, it is oil-free ooze it is current stop distillation, after cooling, to condensate liquid separating-purifying 5 times to get.
Lavender: fresh lavender flower and stem are placed directly within distilling apparatus and carry out air-distillation, heating
To 120 DEG C, until condensing droplet is on a glass, it is oil-free to ooze current stopping distillation, after cooling, to condensate liquid separating-purifying 5 times,
To obtain the final product.
Fragrant camphor tree leaf essential oil: fragrant camphor tree leaf is placed in distilling apparatus and carries out air-distillation, 110 DEG C are warming up to, until condensing droplet exists
On glass plate, it is oil-free ooze it is current stop distillation, after cooling, to condensate liquid separating-purifying 3 times to get.
Geranium Essential: being handled using flower, blade and stem of the steam distillation to fish pelargonium, from seeing
One drop condensing droplet occurs starting timing, after 4h, terminates distillation, distillation speed 90mL/h oozes condensate liquid weight with above-mentioned
0.6 times of anhydrous sodium sulfate is dried, obtain with like rose, spearmint taste light olive-green liquid to get.
Clary sage essential oil: being handled Clary Sage flower and blade using steam distillation, from seeing
First drop condensing droplet occurs starting timing, after 6h, terminates distillation, distillation speed 80mL/h, to the above-mentioned condensate liquid oozed
Purification 3 times to get.
Ginger essential oil: ginger powder progress supercritical carbon dioxide extraction is obtained；Supercritical carbon dioxide fluid extraction
The pressure taken be 30MPa, temperature be 80 DEG C, extraction time be 3 hours to get.
Embodiment 1
The present embodiment provides a kind of essential oil compositions, are grouped as by each group of following parts by weight: 30 parts of ginger essential oil, black Hu
10 parts of green pepper essential oil, 5 parts of Geranium Essential, 20 parts of clary sage essential oil, 1 part of Lavender, fragrant 5 parts of essential oil of camphor tree leaf.
The present embodiment provides abdomen simultaneously and releives essential oil massage cream, each component including following parts by weight: essential oil composition
12 parts, 2.5 parts of cetostearyl alcohol, 0.1 part of xanthan gum, 0.5 part of cetearyl glucoside, 1 part of stearine, PEG~
100 0.2 part of stearates, 0.8 part of inulin lauryl carbamate, 3 parts of caprylic/capric triglyceride, polydimethylsiloxanes
3 parts of alkane, 0.1 part of Phenoxyethanol, 1 part of pungent glycol, 10 parts of glycerol, 1 part of tocopherol acetate, 0.05 part of EDETATE SODIUM, fourth hydroxyl first
2 parts of benzene, 80 parts of water.
Above-mentioned abdomen is releived the preparation method of essential oil massage cream, comprising the following steps:
S1. by said ratio by essential oil composition, caprylic/capric triglyceride, dimethyl silicone polymer, EDETATE SODIUM,
Butylated Hydroxytoluene, Phenoxyethanol, pungent glycol, cetearyl glucoside, stearine and the stearic acid of PEG~100 investment oil
In phase agitated kettle, mixing speed 35rpm is warming up to 85 DEG C, and mixing time 30min obtains A phase；
S2. water, glycerol, tocopherol acetate, the pure and mild xanthan gum of cetearyl alcohol are put into water phase agitated kettle by said ratio
In, mixing speed 30rpm is warming up to 85 DEG C, and mixing time 30min obtains B phase；
S3. the A phase in step S1, S2 is placed in emulsion pot with B phase, homogeneous 5min, then vacuum defoamation is handled
10min, it is cooling；
S4. after being cooled to 48 DEG C, inulin lauryl carbamate, mixing speed 25rpm is added, mixing time is
30min, discharging, obtains semi-finished product；
S5. by semi-finished product after the assay was approved by every dress 10g metering, manual filling installs bottle cap, then fills product
Enter PVC bubble-cap shell carry out plastic uptake heat sealing to get.
Embodiment 2
The present embodiment provides a kind of essential oil compositions, are grouped as by each group of following parts by weight: 10 parts of ginger essential oil, black Hu
30 parts of green pepper essential oil, 20 parts of Geranium Essential, 5 parts of clary sage essential oil, 10 parts of Lavender, fragrant 2 parts of essential oil of camphor tree leaf.
The present embodiment provides abdomen simultaneously and releives essential oil massage cream, each component including following parts by weight: essential oil composition 2
Part, 4 parts of cetostearyl alcohol, 2 parts of xanthan gum, 1.5 parts of cetearyl glucoside, 0.2 part of stearine, PEG~100 are hard
1 part of resin acid ester, 0.1 part of inulin lauryl carbamate, 5 parts of caprylic/capric triglyceride, 1 part of dimethyl silicone polymer, benzene
1 part of oxyethanol, 0.5 part of pungent glycol, 20 parts of glycerol, 2 parts of tocopherol acetate, 0.1 part of EDETATE SODIUM, 0.5 part of Butylated Hydroxytoluene, water
60 parts.
Above-mentioned abdomen releive essential oil massage cream preparation method referring to embodiment 1.
Embodiment 3
The present embodiment provides a kind of essential oil compositions, are grouped as by each group of following parts by weight: 20 parts of ginger essential oil, black Hu
15 parts of green pepper essential oil, 8 parts of Geranium Essential, 15 parts of clary sage essential oil, 5 parts of Lavender, fragrant 4 parts of essential oil of camphor tree leaf.
The present embodiment provides abdomen simultaneously and releives essential oil massage cream, each component including following parts by weight: essential oil composition 4
Part, 3.5 parts of cetostearyl alcohol, 0.5 part of xanthan gum, 1 part of cetearyl glucoside, 0.4 part of stearine, PEG~100
0.5 part of stearate, 0.3 part of inulin lauryl carbamate, 4 parts of caprylic/capric triglyceride, dimethyl silicone polymer
2.5 parts, 0.3 part of Phenoxyethanol, 0.8 part of pungent glycol, 15 parts of glycerol, 1.8 parts of tocopherol acetate, 0.06 part of EDETATE SODIUM, fourth
1 part of hydroxy toluene, 70 parts of water.
Above-mentioned abdomen releive essential oil massage cream preparation method referring to embodiment 1.
Embodiment 4
The present embodiment provides a kind of essential oil compositions, are grouped as by each group of following parts by weight: 18 parts of ginger essential oil, black Hu
16 parts of green pepper essential oil, 12 parts of Geranium Essential, 12 parts of clary sage essential oil, 3 parts of Lavender, fragrant 1 part of essential oil of camphor tree leaf.
The present embodiment provides abdomen simultaneously and releives essential oil massage cream, each component including following parts by weight: essential oil composition
10 parts, 3 parts of cetostearyl alcohol, 1.5 parts of xanthan gum, 1.2 parts of cetearyl glucoside, 0.5 part of stearine, PEG~
100 0.8 part of stearates, 0.6 part of inulin lauryl carbamate, 4.5 parts of caprylic/capric triglyceride, poly dimethyl silicon
2 parts of oxygen alkane, 0.6 part of Phenoxyethanol, 0.8 part of pungent glycol, 12 parts of glycerol, 1.2 parts of tocopherol acetate, 0.08 part of EDETATE SODIUM,
1.5 parts of Butylated Hydroxytoluene, 72 parts of water.
Above-mentioned abdomen releive essential oil massage cream preparation method referring to embodiment 1.
Embodiment 5
Indices detection is carried out according to the massage cream that 1857~2013 pairs of Examples 1 to 4 of standard QB/T are prepared,
Testing result is as follows:
(1) organoleptic indicator
Appearance: white body is fine and smooth, uniformity；
Fragrance: distinctive medicine perfume (or spice) odor type fragrance；
Color: yellow.
(2) physical and chemical index
PH value (25 DEG C): 6.3；
Heat-resistant stability: kept at 40 ± 1 DEG C for 24 hours, restore to after room temperature with test before no significant difference；
Cold-resistant stability: keeping for 24 hours at~8 ± 2 DEG C, after restoring to room temperature with test before no significant difference.
(3) hygienic chemistry and microbiological indicator
Massage cream product prepared by the present invention is detected by the method for " cosmetics health specification " 2015, testing result is shown in Table 1.
Table 1
| Sanitary index | Standard requirements | Testing result | Single item evaluation |
| Total plate count, CFU/g | ≤1000 | ≤516 | It is qualified |
| Yeast and mold sum, CFU/g | ≤100 | ≤42 | It is qualified |
| Heat-resisting coliform, g | It must not detect | It is not detected | It is qualified |
| Staphylococcus aureus, g | It must not detect | It is not detected | It is qualified |
| Pseudomonas aeruginosa, g | It must not detect | It is not detected | It is qualified |
| Mercury, mg/kg | ≤1 | ≤0.7 | It is qualified |
| Lead, mg/kg | ≤10 | ≤4.5 | It is qualified |
| Arsenic, mg/kg | ≤2 | ≤1.0 | It is qualified |
| Cadmium, mg/kg | ≤5 | ≤3.4 | It is qualified |
Test result shows that abdomen of the invention releives essential oil massage cream higher than national standard, safety approval.
(4) application method
Position needed for taking appropriate this product to be applied to abdomen skin is massaged until fully absorbing.
(5) specified risk material safety evaluation
Each raw material for preparing massage cream to the present invention carries out specified risk material security evaluation, and specific assessment result is shown in Table 2.
Table 2
Product safety test
By taking the product of embodiment 1 and 4 as an example, toxicity and irritative response of the observation product external application to skin.
1, dermal toxicity test
Healthy adult rabbit is taken, if intact skin and damaged skin group, and respectively set blank control group.Tested abdomen is releived essence
Oily massage cream contact rabbit is completely and after damaged skin, measurement breathing, heart rate and four limbs activity etc..
As a result it releives before essential oil massage cream with wiping abdomen and comparison among groups, statistically there was no significant difference, also there are no
Systemic toxicity.
2, skin irritation test
(1) skin irritation test is carried out using rabbit, divides intact skin group and damage skin group, for 24 hours by rabbit before test
Back backbone diamond wool shaves off, glutinous with releive essential oil massage cream and family's rabbit skin of abdomen prepared by the embodiment of the present invention 1 and 4 respectively
After film is kept in contact 1d, continuous 7d, whether there is or not the stimulate the reactions such as erythema, oedema for observation skin.
(2) skin allergy experiment is carried out using cavy, is releived essential oil with abdomen prepared by the embodiment of the present invention 1 and 4 weekly
Massage cream and guinea pig skin mucous membrane are kept in contact 2 times, contact 4h or more every time, continuous 3 weeks, whether there is or not erythema, oedema for observation skin
Equal allergic reactions.
Experimental result:
The intact skin and damaged skin of rabbit, remove after being intended for single use or be used for multiple times for 24 hours, respectively at 1,24,48,
72h observation, is showed no erythema and oedema, and stimulate the reaction mean scores are < 0.5, nonirritant.
In guinea pig skin allergic experiment, does not occur the cutaneous anaphylaxises such as the obvious erythema of skin, oedema and other are systemic
Allergic reaction.
Therefore, abdomen of the invention releive essential oil massage cream to rabbit intact skin and damage skin will not cause irritation
Reaction has good cutaneous safety to guinea pig skin without allergic reaction.
Comparative example 1
Referring to the process conditions of embodiment 4, the main distinction is this comparative example, and abdomen is releived in essential oil massage cream without black
Pepper essential oil and ginger essential oil.
Comparative example 2
Referring to the process conditions of embodiment 4, the main distinction is this comparative example, and abdomen is releived in essential oil massage cream without black
Pepper essential oil.
Comparative example 3
Referring to the process conditions of embodiment 4, the main distinction is this comparative example, and abdomen is releived in essential oil massage cream without life
Ginger essential oil.
Comparative example 4
Referring to the process conditions of embodiment 4, the main distinction is this comparative example, and abdomen is releived in essential oil massage cream without fast
Happy Salvia japonica essential oil, Lavender and fragrant camphor tree leaf essential oil.
Comparative example 5
Referring to the process conditions of embodiment 4, the main distinction is this comparative example, and abdomen is releived in essential oil massage cream without fast
Happy Salvia japonica essential oil.
Comparative example 6
Referring to the process conditions of embodiment 4, the main distinction is this comparative example, and abdomen is releived in essential oil massage cream without smoking
Clothing grass essential oil.
Comparative example 7
Referring to the process conditions of embodiment 4, the main distinction is this comparative example, and abdomen is releived in essential oil massage cream without virtue
Camphor tree leaf essential oil.
Comparative example 8
Referring to the process conditions of embodiment 4, the main distinction is this comparative example, and abdomen is releived in essential oil massage cream without day
Zhu Kui essential oil.
Comparative example 9
The process conditions of this comparative example reference embodiment 4, the main distinction are that essential oil composition is by following parts by weight of component
Composition: 8 parts of ginger essential oil, 35 parts of black pepper essential oil, 25 parts of Geranium Essential, 4 parts of clary sage essential oil, Lavender
0.5 part, fragrant 0.5 part of essential oil of camphor tree leaf.
Comparative example 10
The process conditions of this comparative example reference embodiment 4, the main distinction are that essential oil composition is by following parts by weight of component
Composition: 35 parts of ginger essential oil, 9 parts of black pepper essential oil, 4 parts of Geranium Essential, 21 parts of clary sage essential oil, Lavender 12
Part, fragrant 6 parts of essential oil of camphor tree leaf.
Product measure of merit
Mice clinical test is carried out to each embodiment and comparative example, to measure different groups for the therapeutic effect of dysmenorrhea.
1.1 material
1.1.1 animal
Healthy adult female Wistar rats, cleaning grade, 180~200g of weight.
1.1.2 reagent and material
Rat blood serum IFN~kit；IL~4ELISA kit；P of Rats GF2 enzyme-linked immunologic detecting kit；L~essence
Propylhomoserin methyl esters (L~NAME) and Rockwell liquid (Locke's solu~tion)；
1.1.3 instrument
MacLab/4e channel polygraph；
1.2 mouse analgesic tests
1.2.1 pain model in mice is established using 55 DEG C of thermostimulations
Magnetic mouse is placed on the constant temperature hot-plate instrument for being preheating to 55 DEG C, to lick metapedes as pain reaction, is to lick metapedes
Pain reaction, to there is licking incubation period of metapedes as the mean of pain threshold 2 threshold of pains using before medicine as the basic threshold of pain.
1.2.2 influence of the measurement massage cream to mouse pain threshold
The mouse for choosing Basic Pain Threshold value before being administered qualified (threshold of pain is greater than 5s, is less than 30s), is randomly divided into 15 groups, every group
10, give 1~14 group, wherein 1~4 group give Examples 1 to 4 group offer massage cream, 5~14 groups give comparative example 1~
The massage cream of 10 groups of offers, the 15th group is blank control group, gives same dosage distilled water, records 15 groups of mouse reactions, inspection respectively
The results are shown in Table 3 for survey:
The pain threshold of 15 groups of mouse after table 3 is administered
The abdomen that Examples 1 to 4 can be seen that Examples 1 to 4 offer compared with blank control group from table 3 is releived
Essential oil massage cream can significantly improve the threshold value of mouse, this illustrates that massage cream provided by the invention has apparent analgesic effect.
Embodiment 4 is compared with comparative example 1~10 as can be seen that the massage cream that embodiment 4 provides passes through specific matter from table 3
Measure ginger essential oil, black pepper essential oil, Geranium Essential, clary sage essential oil, the Lavender, fragrant camphor tree leaf essential oil association of number
With cooperation, more preferably to the analgesic effect of mouse.
1.3 rat analgesic experiments
1.3.1 rat dysmenorrhea model is established using oxytocin method
Using dysmenorrhea model Isolated Rat Uterus smooth muscle contraction amplitude, frequency as index, Examples 1 to 4 and comparison are evaluated
The abdomen that example 1~10 provides is releived influence of the essential oil massage cream to the smooth musculation of rat uterus
1.3.2 experimental method
The female sd inbred rats that oxytocin induces dysmenorrhea model are randomly divided into 15 groups, every group 10, respectively 1~15 group,
Wherein the 15th group be blank control group, in addition to the 15th group, other rats daily be subcutaneously injected diethylstilbestrol 2mg/kg, continuous 10
It.Since subcutaneous injection diethylstilbestrol the 6th day, 1~4 group give respectively Examples 1 to 4 offer abdomen releive essential oil massage
Cream, 5~14 groups of abdomens for giving the offer of comparative example 1~10 respectively are releived essential oil massage cream.15 groups of injection same volume distilled water, even
It is 5 days continuous.Oxytocin 20U/kg is injected intraperitoneally in 1h after the last administration.There is the latent of pain reaction (writhing response) in immediate record rat
Writhing number in Fu Qi, 30min calculates the inhibiting rate of writhing number.
Wherein, writhing number inhibiting rate=(model group writhing number-administration group writhing number)/model group writhing number
× 100%.
The above-mentioned rat of PGF2 assay in rat blood serum, injects 30min after oxytocin, etherization, and abdominal vein takes
Blood after processing, measures the content of PGF2 in each group rat blood serum.After above-mentioned animal pattern takes blood simultaneously, rat is taken out rapidly
Palace is placed in cold Rockwell liquid and cleans, and takes every side cornua uteri middle section 2cm, is fixed in the thermostatic bath for filling 10mL Rockwell liquid, with
On MecLab/4e connected tonotransducer.Solution temperature is 37.5~38 DEG C in bath, and constant is passed through 95%O+5%CO
Mixed gas.It adjusts micro actuator and adds preload 1g, balance 40min, restore spontaneous rhythm, contraction frequency and amplitude stabilization to uterus
Afterwards, the contraction frequency and amplitude in groups of animals uterus are recorded.
Influence of 4 drug of table to rat model
The abdomen that Examples 1 to 4 and blank control group can be seen that Examples 1 to 4 offer from table 4 releive essential oil by
The cream that rubs can significantly extend the incubation period of rat pain, reduce the writhing number of rat, this illustrates the abdomen that Examples 1 to 4 provides
Essential oil massage cream of releiving has significant analgesic effect.
From Examples 1 to 4 compared with comparative example 1~10 as can be seen that Examples 1 to 4 provide abdomen releive essential oil by
The cream that rubs passes through the Lavender of extra fine quality number, Geranium Essential, clary sage essential oil, ginger essential oil, black pepper essence
Oil and fragrant camphor tree leaf essential oil coordinated, more preferably to the analgesic effect of rat.
Influence of 5 drug of table to PEG2 in Isolated Rat Uterus contraction frequency and amplitude and serum
As can be seen from Table 5, the uterine myometrium frequency of rat is substantially less than blank control in Examples 1 to 4
Group, PGF2αSubstantially less than blank control group, this illustrates that the abdomen essential oil massage cream of releiving that Examples 1 to 4 provides can significantly drop
Influence of the low oxytocin to rat uterus smooth muscle contraction inhibits PEG2 in rat bodyαSynthesis or release, reduce pain.
The abdomen that can be seen that Examples 1 to 4 offer compared with comparative example 1~10 from Examples 1 to 4 is releived essential oil
Massage cream passes through Lavender, Geranium Essential, clary sage essential oil, ginger essential oil, black pepper essential oil and fragrant camphor tree leaf essence
Oily coordinated more can significantly reduce influence of the oxytocin to rat uterus smooth muscle contraction, inhibit PEG2 in rat bodyαConjunction
At or release, reduce pain.
Using effect scoring
By the abdomen that above-described embodiment 1~4 and comparative example 1~10 are prepared releive essential oil massage cream carry out effect performance
Female patient 200 with dysmenorrhea history are chosen in test, and the age 17~38 years old, all patients were in age, the course of disease and pain degree
Upper no significant difference, is comparable.
The abdomen that Examples 1 to 4 and comparative example 1~10 are prepared is releived essential oil massage cream, in menalgia or
3~7 days before menstrual period, above-mentioned massage cream is applied to respectively at the Guanyuan point of navel and the lower three cun of underbellies of navel, gently massages 3~5
Minute.All patients are releived essential oil with the experience scoring mean value of 3 menstrual cycles to investigate evaluation abdomen of the present invention
The performance of massage cream, evaluation criterion are as shown in table 6.
6 standards of grading of table
| Scoring | Description |
| 80~100 | Effect is obvious |
| 60~80 | Effect is general |
| 40~60 | There is a degree of improvement |
| < 40 points | No effect |
After test carries out 3 menstrual cycles, acquisition experimental result is as shown in table 7:
Abdomen of the invention essential oil massage cream of releiving contains various plants composition, also include caprylic/capric triglyceride,
A variety of skin-moisturizing, skin ingredients such as dimethyl silicone polymer and glycerol are answered with having the essential oil composition in warm palace, alleviation dysmenorrhea effect
Match, be easy to absorb, gently abdomen massage skin when use can reach nursing of releiving, analgesia, balance and other effects, additionally it is possible to rise
To warm palace, alleviate the effect of dysmenorrhea, and trier will not be brought and significantly affect the side effects such as blood volume.
Obviously, above-described embodiment is only intended to clearly illustrate technical solution of the present invention example, and is not
Restriction to embodiments of the present invention.For those of ordinary skill in the art, on the basis of the above description also
It can make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.It is all
Made any modifications, equivalent replacements, and improvements etc. within the spirit and principles in the present invention should be included in right of the present invention and want
Within the protection scope asked.
Claims (10)
- The essential oil composition 1. a kind of abdomen is releived, which is characterized in that be grouped as by each group of following parts by weight:10 ~ 30 parts of ginger essential oil, 10 ~ 30 parts of black pepper essential oil, 5 ~ 20 parts of Geranium Essential, 5 ~ 20 parts of clary sage essential oil, 1 ~ 10 part of Lavender, fragrant 1 ~ 5 part of essential oil of camphor tree leaf.
- 2. abdomen is releived essential oil composition according to claim 1, which is characterized in that be grouped by each group of following parts by weight At: 15 ~ 25 parts of ginger essential oil, 8 ~ 15 parts of Geranium Essential, 8 ~ 15 parts of clary sage essential oil, smokes 15 ~ 25 parts of black pepper essential oil 1 ~ 5 part of clothing grass essential oil, fragrant 1 ~ 2 part of essential oil of camphor tree leaf.
- A kind of essential oil massage cream 3. abdomen is releived, which is characterized in that each component including following parts by weight: claims 1 or 2 institute 2 ~ 12 parts of the essential oil composition stated, 3 ~ 6 parts of thickener, 1 ~ 4 part of emulsifier, 4 ~ 8 parts of emollient, 0.5 ~ 1 part of preservative, moisturizer 10 ~ 20 parts, 1 ~ 2 part of skin conditioning agent, 0.05 ~ 0.1 part of chelating agent, 0.5 ~ 2 part of antioxidant, 60 ~ 80 parts of water.
- 4. abdomen is releived essential oil massage cream according to claim 3, which is characterized in that each component including following parts by weight: 4 ~ 10 parts of essential oil composition as claimed in claim 1 or 2,3 ~ 5 parts of thickener, 2 ~ 4 parts of emulsifier, 6 ~ 8 parts of emollient, preservative 0.8 ~ 1 part, 12 ~ 15 parts of moisturizer, 1.5 ~ 1.8 parts of skin conditioning agent, 0.08 ~ 0.1 part of chelating agent, 1 ~ 1.5 part of antioxidant, water 70 ~ 80 parts.
- 5. being releived essential oil massage cream according to the abdomen of claim 3 or 4, which is characterized in that the thickener is by cetearyl alcohol 2.5 ~ 4 parts of alcohol, 0.1 ~ 2 part of xanthan gum composition.
- 6. being releived essential oil massage cream according to the abdomen of claim 3 or 4, which is characterized in that the emulsifier is by cetearyl alcohol 0.5 ~ 1.5 part of base glucoside, 0.2 ~ 1 part of stearine, 0.2 ~ 1 part of the stearate of PEG ~ 100, inulin lauryl base amino 0.1 ~ 0.8 part of formic acid esters composition.
- 7. being releived essential oil massage cream according to the abdomen of claim 3 or 4, which is characterized in that the emollient is by caprylic/capric 3 ~ 5 parts of triglycerides, 1 ~ 3 part of dimethyl silicone polymer composition.
- 8. being releived essential oil massage cream according to the abdomen of claim 3 or 4, which is characterized in that the preservative is by Phenoxyethanol 0.1 ~ 1 part, 0. 5 ~ 1 part of pungent glycol composition.
- 9. being releived essential oil massage cream according to the abdomen of claim 3 or 4, which is characterized in that the moisturizer is glycerol, described Skin conditioning agent is tocopherol acetate, and the chelating agent is EDETATE SODIUM, and the antioxidant is Butylated Hydroxytoluene.
- 10. being releived the preparation method of essential oil massage cream according to any one of claim 3 ~ 9 abdomen, which is characterized in that including Following steps:S1. essential oil composition, emollient, chelating agent, antioxidant, preservative and partial emulsifier are put into oil by said ratio In phase agitated kettle, mixing speed is 25 ~ 35 rpm, is warming up to 80 ~ 85 DEG C, and mixing time is 30 ~ 35 min, obtains A phase；S2. by said ratio by water, moisturizer, skin conditioning agent, thickener investment water phase agitated kettle in, mixing speed be 25 ~ 35 rpm are warming up to 80 ~ 85 DEG C, and mixing time is 30 ~ 35 min, obtains B phase；S3. the A phase in step S1, S2 is placed in emulsion pot with B phase, homogeneous for a period of time after, carry out vacuum defoamation processing after, It is cooling；S4. after being cooled to 48 DEG C, remainder emulsifier is added, mixing speed is 25 ~ 35 rpm, and mixing time is 30 ~ 35 Min, discharging, obtains semi-finished product；S5. semi-finished product are tested, are filling, packaging after to get.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111840135A (en) * | 2020-07-20 | 2020-10-30 | 广州市科能化妆品科研有限公司 | Soothing composition and preparation method and application thereof |
| CN115887606A (en) * | 2022-11-01 | 2023-04-04 | 上海中医药大学 | Compound plant essential oil composition for treating dysmenorrhea caused by cold accumulation, qi stagnation and blood stasis |
| CN117547505A (en) * | 2024-01-10 | 2024-02-13 | 广州市发雅丝精细化工有限公司 | Preparation method of massage cream for relaxing and activating channels and collaterals |
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| 红柳: "《古代女性花卉养生、养颜秘笈全书》", 30 September 2013, 黑龙江科学技术出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111840135A (en) * | 2020-07-20 | 2020-10-30 | 广州市科能化妆品科研有限公司 | Soothing composition and preparation method and application thereof |
| CN115887606A (en) * | 2022-11-01 | 2023-04-04 | 上海中医药大学 | Compound plant essential oil composition for treating dysmenorrhea caused by cold accumulation, qi stagnation and blood stasis |
| CN115887606B (en) * | 2022-11-01 | 2024-03-01 | 上海中医药大学 | Compound plant essential oil composition for dysmenorrhea caused by cold coagulation, qi stagnation and blood stasis |
| CN117547505A (en) * | 2024-01-10 | 2024-02-13 | 广州市发雅丝精细化工有限公司 | Preparation method of massage cream for relaxing and activating channels and collaterals |
| CN117547505B (en) * | 2024-01-10 | 2024-04-05 | 广州市发雅丝精细化工有限公司 | Preparation method of massage cream for relaxing and activating channels and collaterals |
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Application publication date: 20190412 |